               SEQUENCE LISTING

<110> INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
      UNIVERSITE D'AIX MARSEILLE

<120> Means for detecting or measuring a biological activity of a botulinum toxin

<130> PR75138/KLP/CJ

<160> 27

<170> BiSSAP 1.3

<210> 1
<211> 2376
<212> DNA
<213> Homo sapiens

<400> 1
atggaagaag ggtttcgcga tagggctgcg tttatcagag gagccaaaga catcgctaag      60

gaggtgaaga agcatgccgc aaagaaagtg gtgaaagggc tcgatagagt gcaagacgag     120

tactcacgaa ggtcttacag ccgattcgag gaggaagatg acgatgatga cttccctgcg     180

ccaagcgacg gctactacag gggtgagggc actcaggatg aggaagaggg tggagcatcc     240

tccgatgcaa cggaagggca tgacgaggac gacgagattt acgaaggcga atatcagggg     300

attccacgtg ctgagtcagg agggaagggc gaacggatgg ctgatggagc tccattagcc     360

ggagtccgtg gtggcctgag tgatggcgag ggtcctcctg gcggcagagg cgaagcccaa     420

cggcgcaaag aacgcgaaga gttagcccag cagtatgagg caatccttcg ggaatgcggg     480

catggacggt ttcagtggac actctacttt gtgctcggac tggccctgat ggctgacggg     540

gtagaagtgt tcgttgtcgg attcgtccta ccgagtgccg agaaagacat gtgcctgtct     600

gacagtaaca aggggatgtt gggtctaatc gtgtatctgg gcatgatggt tggtgccttt     660

ctttggggtg ggctggcaga tcgcttggga aggaggcagt gtctccttat tagcctgtca     720

gtgaatagcg tctttgcctt cttctccagc ttcgtccaag gttatggcac ctttctcttt     780

tgtcggctgt tgtcaggggt aggcatcggc ggatctattc ccatcgtttt cagctatttc     840

agcgagtttc tggctcagga gaagagaggc gagcacctgt cttggctttg catgttctgg     900

atgataggag gagtttacgc agcagccatg gcttgggcta tcatacccca ctatggctgg     960

tccttccaga tggggtctgc ctaccagttc cactcctgga gagtgttcgt actggtgtgt    1020

gcctttccca gtgtgtttgc cattggcgcg ctcactacac agcccgaatc tccacgattc    1080

ttcctggaaa acggtaagca cgacgaagct tggatggtgc tcaaacaggt tcacgatacc    1140

aatatgagag ccaaaggcca tccggaacgc gttttcagcg tgactcacat caagacaatc    1200

catcaggagg atgagcttat cgagattcag tctgacacag gaacctggta tcagcgctgg    1260

ggagtcagag cactatccct cggtggccaa gtgtggggca attttctgtc ctgtttcggg    1320

cctgagtatc ggcggataac ccttatgatg atgggagtct ggttcacgat gagctttagc    1380

tactatgggt tgaccgtgtg gtttcccgat atgattcgcc atttgcaagc cgttgattac    1440

gcttccagga ctaaagtctt tccaggcgaa agggtcgagc atgtgacatt taacttcact    1500

ctcgagaatc agatccacag aggcgggcag tacttcaatg acaagttcat tggcttaagg    1560

ctcaagtctg taagctttga ggattctctg tttgaagagt gctattttga ggatgtgact    1620

agttccaaca cgttctttcg taattgtacg ttcattaaca cagttttcta caataccgat    1680

ctctttgagt acaagtttgt gaactcacgg ctgattaaca gcacctttct gcacaacaaa    1740

gaggggtgtc cactggacgt taccggaacc ggtgaagggg catacatggt gtacttcgtg    1800

tcattcttgg gcacactggc cgtactccct ggtaacatag tgtctgcctt gctgatggac    1860

aagatcggta gacttcggat gcttgccgga tcaagtgtga tgagttgcgt gtcctgtttc    1920

ttcctgtcat tcggcaatag cgagagtgcg atgatagcac tgctgtgcct tttcggaggg    1980

gtgtcaattg cctcctggaa tgctctcgac gtactaactg tggaactgta tcccagtgac    2040

aaacgaacaa ctgcgtttgg cttcctgaac gcgctgtgca agttagctgc cgtcttgggg    2100

atcagcatct ttaccagctt tgtcggaatc accaaggctg cccctattct gtttgcctcc    2160

gcagctttag cactgggcag ctctttggcc ctaaaactgc ccgaaacaag gggacaagtc    2220

cttcagtctc gcgctggcgc gccccacttc cctgaaatct ccttcccccc taaacccgat    2280

tctgattatc aggccttgct accatccgcg ccagagatct actctcacct ctcccccacc    2340

aaacccgatt acatcaacct tcgaccggcg ccctaa                              2376


<210> 2
<211> 791
<212> PRT
<213> Homo sapiens

<400> 2
Met Glu Glu Gly Phe Arg Asp Arg Ala Ala Phe Ile Arg Gly Ala Lys 
1               5                   10                  15      
Asp Ile Ala Lys Glu Val Lys Lys His Ala Ala Lys Lys Val Val Lys 
            20                  25                  30          
Gly Leu Asp Arg Val Gln Asp Glu Tyr Ser Arg Arg Ser Tyr Ser Arg 
        35                  40                  45              
Phe Glu Glu Glu Asp Asp Asp Asp Asp Phe Pro Ala Pro Ser Asp Gly 
    50                  55                  60                  
Tyr Tyr Arg Gly Glu Gly Thr Gln Asp Glu Glu Glu Gly Gly Ala Ser 
65                  70                  75                  80  
Ser Asp Ala Thr Glu Gly His Asp Glu Asp Asp Glu Ile Tyr Glu Gly 
                85                  90                  95      
Glu Tyr Gln Gly Ile Pro Arg Ala Glu Ser Gly Gly Lys Gly Glu Arg 
            100                 105                 110         
Met Ala Asp Gly Ala Pro Leu Ala Gly Val Arg Gly Gly Leu Ser Asp 
        115                 120                 125             
Gly Glu Gly Pro Pro Gly Gly Arg Gly Glu Ala Gln Arg Arg Lys Glu 
    130                 135                 140                 
Arg Glu Glu Leu Ala Gln Gln Tyr Glu Ala Ile Leu Arg Glu Cys Gly 
145                 150                 155                 160 
His Gly Arg Phe Gln Trp Thr Leu Tyr Phe Val Leu Gly Leu Ala Leu 
                165                 170                 175     
Met Ala Asp Gly Val Glu Val Phe Val Val Gly Phe Val Leu Pro Ser 
            180                 185                 190         
Ala Glu Lys Asp Met Cys Leu Ser Asp Ser Asn Lys Gly Met Leu Gly 
        195                 200                 205             
Leu Ile Val Tyr Leu Gly Met Met Val Gly Ala Phe Leu Trp Gly Gly 
    210                 215                 220                 
Leu Ala Asp Arg Leu Gly Arg Arg Gln Cys Leu Leu Ile Ser Leu Ser 
225                 230                 235                 240 
Val Asn Ser Val Phe Ala Phe Phe Ser Ser Phe Val Gln Gly Tyr Gly 
                245                 250                 255     
Thr Phe Leu Phe Cys Arg Leu Leu Ser Gly Val Gly Ile Gly Gly Ser 
            260                 265                 270         
Ile Pro Ile Val Phe Ser Tyr Phe Ser Glu Phe Leu Ala Gln Glu Lys 
        275                 280                 285             
Arg Gly Glu His Leu Ser Trp Leu Cys Met Phe Trp Met Ile Gly Gly 
    290                 295                 300                 
Val Tyr Ala Ala Ala Met Ala Trp Ala Ile Ile Pro His Tyr Gly Trp 
305                 310                 315                 320 
Ser Phe Gln Met Gly Ser Ala Tyr Gln Phe His Ser Trp Arg Val Phe 
                325                 330                 335     
Val Leu Val Cys Ala Phe Pro Ser Val Phe Ala Ile Gly Ala Leu Thr 
            340                 345                 350         
Thr Gln Pro Glu Ser Pro Arg Phe Phe Leu Glu Asn Gly Lys His Asp 
        355                 360                 365             
Glu Ala Trp Met Val Leu Lys Gln Val His Asp Thr Asn Met Arg Ala 
    370                 375                 380                 
Lys Gly His Pro Glu Arg Val Phe Ser Val Thr His Ile Lys Thr Ile 
385                 390                 395                 400 
His Gln Glu Asp Glu Leu Ile Glu Ile Gln Ser Asp Thr Gly Thr Trp 
                405                 410                 415     
Tyr Gln Arg Trp Gly Val Arg Ala Leu Ser Leu Gly Gly Gln Val Trp 
            420                 425                 430         
Gly Asn Phe Leu Ser Cys Phe Gly Pro Glu Tyr Arg Arg Ile Thr Leu 
        435                 440                 445             
Met Met Met Gly Val Trp Phe Thr Met Ser Phe Ser Tyr Tyr Gly Leu 
    450                 455                 460                 
Thr Val Trp Phe Pro Asp Met Ile Arg His Leu Gln Ala Val Asp Tyr 
465                 470                 475                 480 
Ala Ser Arg Thr Lys Val Phe Pro Gly Glu Arg Val Glu His Val Thr 
                485                 490                 495     
Phe Asn Phe Thr Leu Glu Asn Gln Ile His Arg Gly Gly Gln Tyr Phe 
            500                 505                 510         
Asn Asp Lys Phe Ile Gly Leu Arg Leu Lys Ser Val Ser Phe Glu Asp 
        515                 520                 525             
Ser Leu Phe Glu Glu Cys Tyr Phe Glu Asp Val Thr Ser Ser Asn Thr 
    530                 535                 540                 
Phe Phe Arg Asn Cys Thr Phe Ile Asn Thr Val Phe Tyr Asn Thr Asp 
545                 550                 555                 560 
Leu Phe Glu Tyr Lys Phe Val Asn Ser Arg Leu Ile Asn Ser Thr Phe 
                565                 570                 575     
Leu His Asn Lys Glu Gly Cys Pro Leu Asp Val Thr Gly Thr Gly Glu 
            580                 585                 590         
Gly Ala Tyr Met Val Tyr Phe Val Ser Phe Leu Gly Thr Leu Ala Val 
        595                 600                 605             
Leu Pro Gly Asn Ile Val Ser Ala Leu Leu Met Asp Lys Ile Gly Arg 
    610                 615                 620                 
Leu Arg Met Leu Ala Gly Ser Ser Val Met Ser Cys Val Ser Cys Phe 
625                 630                 635                 640 
Phe Leu Ser Phe Gly Asn Ser Glu Ser Ala Met Ile Ala Leu Leu Cys 
                645                 650                 655     
Leu Phe Gly Gly Val Ser Ile Ala Ser Trp Asn Ala Leu Asp Val Leu 
            660                 665                 670         
Thr Val Glu Leu Tyr Pro Ser Asp Lys Arg Thr Thr Ala Phe Gly Phe 
        675                 680                 685             
Leu Asn Ala Leu Cys Lys Leu Ala Ala Val Leu Gly Ile Ser Ile Phe 
    690                 695                 700                 
Thr Ser Phe Val Gly Ile Thr Lys Ala Ala Pro Ile Leu Phe Ala Ser 
705                 710                 715                 720 
Ala Ala Leu Ala Leu Gly Ser Ser Leu Ala Leu Lys Leu Pro Glu Thr 
                725                 730                 735     
Arg Gly Gln Val Leu Gln Ser Arg Ala Gly Ala Pro His Phe Pro Glu 
            740                 745                 750         
Ile Ser Phe Pro Pro Lys Pro Asp Ser Asp Tyr Gln Ala Leu Leu Pro 
        755                 760                 765             
Ser Ala Pro Glu Ile Tyr Ser His Leu Ser Pro Thr Lys Pro Asp Tyr 
    770                 775                 780                 
Ile Asn Leu Arg Pro Ala Pro 
785                 790     

<210> 3
<211> 175
<212> PRT
<213> Homo sapiens

<400> 3
Ile Thr Leu Met Met Met Gly Val Trp Phe Thr Met Ser Phe Ser Tyr 
1               5                   10                  15      
Tyr Gly Leu Thr Val Trp Phe Pro Asp Met Ile Arg His Leu Gln Ala 
            20                  25                  30          
Val Asp Tyr Ala Ser Arg Thr Lys Val Phe Pro Gly Glu Arg Val Glu 
        35                  40                  45              
His Val Thr Phe Asn Phe Thr Leu Glu Asn Gln Ile His Arg Gly Gly 
    50                  55                  60                  
Gln Tyr Phe Asn Asp Lys Phe Ile Gly Leu Arg Leu Lys Ser Val Ser 
65                  70                  75                  80  
Phe Glu Asp Ser Leu Phe Glu Glu Cys Tyr Phe Glu Asp Val Thr Ser 
                85                  90                  95      
Ser Asn Thr Phe Phe Arg Asn Cys Thr Phe Ile Asn Thr Val Phe Tyr 
            100                 105                 110         
Asn Thr Asp Leu Phe Glu Tyr Lys Phe Val Asn Ser Arg Leu Ile Asn 
        115                 120                 125             
Ser Thr Phe Leu His Asn Lys Glu Gly Cys Pro Leu Asp Val Thr Gly 
    130                 135                 140                 
Thr Gly Glu Gly Ala Tyr Met Val Tyr Phe Val Ser Phe Leu Gly Thr 
145                 150                 155                 160 
Leu Ala Val Leu Pro Gly Asn Ile Val Ser Ala Leu Leu Met Asp 
                165                 170                 175 

<210> 4
<211> 2424
<212> DNA
<213> Homo sapiens

<220> 
<223> Sequence amended in order to incorporate a T7 Tag peptide

<400> 4
atggaggaag gattccggga ccgggctgca ttcattcggg gagcaaaaga cattgctaag      60

gaagtgaaga aacatgcagc aaagaaagtg gtgaagggac tcgacagagt gcaagatgag     120

tattccagaa gaagctattc caggttcgaa gaagaggatg acgatgacga ttttcctgct     180

ccaagcgatg gatattacag aggagagggc acacaggatg aagaagaagg aggcgcaagc     240

agcgacgcta cagaagggca cgacgaggat gatgaaatct acgaaggaga ataccaggga     300

atcccaagag ctgaaagcgg aggcaaagga gagagaatgg ctgatggggc tcctctggca     360

ggagtgagag gagggctgtc cgatggagaa ggccctcccg ggggaagagg agaagcacag     420

cggaggaaag aaagggagga gctggctcag cagtatgagg ctatcctgcg ggaatgcggg     480

catggaagat tccaatggac tctgtatttc gtgctcggac tggcactgat ggctgacgga     540

gtcgaagtgt ttgtggtcgg atttgtgctg ccatccgctg agaaagacat gtgtctggga     600

gctggaatgg cctccatgac aggaggacag cagatgggag cttccagcga ttccaacaag     660

ggcatgctgg gactgattgt gtatctggga atgatggtcg gcgcctttct ctggggagga     720

ctggctgaca gactgggcag aaggcaatgt ctcctcatct ccctgagcgt gaattccgtc     780

tttgccttct tctcctcctt cgtccaaggc tacggcactt tcctgttctg tcgcctgctg     840

agcggcgtgg gaattggagg gtccatccca attgtgttct cctatttctc cgaattcctg     900

gcccaagaaa agaggggcga gcatctgagc tggctgtgta tgttttggat gatcggcgga     960

gtgtacgccg ccgcaatggc ctgggctatt atcccacact atggctggtc ctttcaaatg    1020

ggcagcgcct accaattcca ttcctggaga gtctttgtcc tggtgtgtgc atttcccagc    1080

gtgtttgcca ttggcgctct gaccacccag cccgaatccc cacggttctt tctggaaaat    1140

gggaaacacg atgaggcttg gatggtgctg aaacaggtgc atgatactaa catgagagct    1200

aaaggccatc cggaacgcgt tttcagcgtg actcacatca agacaatcca tcaggaggat    1260

gagcttatcg agattcagtc tgacacagga acctggtatc agcgctgggg agtcagagca    1320

ctatccctcg gtggccaagt gtggggcaat tttctgtcct gtttcgggcc tgagtatcgg    1380

cggataaccc ttatgatgat gggagtctgg ttcacgatga gctttagcta ctatgggttg    1440

accgtgtggt ttcccgatat gattcgccat ttgcaagccg ttgattacgc ttccaggact    1500

aaagtctttc caggcgaaag ggtcgagcat gtgacattta acttcactct cgagaatcag    1560

atccacagag gcgggcagta cttcaatgac aagttcattg gcttaaggct caagtctgta    1620

agctttgagg attctctgtt tgaagagtgc tattttgagg atgtgactag ttccaacacg    1680

ttctttcgta attgtacgtt cattaacaca gttttctaca ataccgatct ctttgagtac    1740

aagtttgtga actcacggct gattaacagc acctttctgc acaacaaaga ggggtgtcca    1800

ctggacgtta ccggaaccgg tgaaggggca tacatggtgt acttcgtgtc attcttgggc    1860

acactggccg tactccctgg taacatagtg tctgccttgc tgatggacaa gatcggtaga    1920

cttcggatgc ttgccggatc aagtgtgatg agttgcgtgt cctgtttctt cctgtcattc    1980

ggcaatagcg agagtgcgat gatagcactg ctgtgccttt tcggaggggt gtcaattgcc    2040

tcctggaatg ctctcgacgt actaactgtg gaactgtatc ccagtgacaa acgaacaact    2100

gcgtttggct tcctgaacgc gctgtgcaag ttagctgccg tcttggggat cagcatcttt    2160

accagctttg tcggaatcac caaggctgcc cctattctgt ttgcctccgc agctttagca    2220

ctgggcagct ctttggccct aaaactgccc gaaacaaggg gacaagtcct tcagtctcgc    2280

gctggcgcgc cccacttccc tgaaatctcc ttccccccta aacccgattc tgattatcag    2340

gccttgctac catccgcgcc agagatctac tctcacctct cccccaccaa acccgattac    2400

atcaaccttc gaccggcgcc ctaa                                           2424


<210> 5
<211> 807
<212> PRT
<213> Homo sapiens

<220> 
<223> sequence amended in order to incorporate a T7 Tag peptide

<400> 5
Met Glu Glu Gly Phe Arg Asp Arg Ala Ala Phe Ile Arg Gly Ala Lys 
1               5                   10                  15      
Asp Ile Ala Lys Glu Val Lys Lys His Ala Ala Lys Lys Val Val Lys 
            20                  25                  30          
Gly Leu Asp Arg Val Gln Asp Glu Tyr Ser Arg Arg Ser Tyr Ser Arg 
        35                  40                  45              
Phe Glu Glu Glu Asp Asp Asp Asp Asp Phe Pro Ala Pro Ser Asp Gly 
    50                  55                  60                  
Tyr Tyr Arg Gly Glu Gly Thr Gln Asp Glu Glu Glu Gly Gly Ala Ser 
65                  70                  75                  80  
Ser Asp Ala Thr Glu Gly His Asp Glu Asp Asp Glu Ile Tyr Glu Gly 
                85                  90                  95      
Glu Tyr Gln Gly Ile Pro Arg Ala Glu Ser Gly Gly Lys Gly Glu Arg 
            100                 105                 110         
Met Ala Asp Gly Ala Pro Leu Ala Gly Val Arg Gly Gly Leu Ser Asp 
        115                 120                 125             
Gly Glu Gly Pro Pro Gly Gly Arg Gly Glu Ala Gln Arg Arg Lys Glu 
    130                 135                 140                 
Arg Glu Glu Leu Ala Gln Gln Tyr Glu Ala Ile Leu Arg Glu Cys Gly 
145                 150                 155                 160 
His Gly Arg Phe Gln Trp Thr Leu Tyr Phe Val Leu Gly Leu Ala Leu 
                165                 170                 175     
Met Ala Asp Gly Val Glu Val Phe Val Val Gly Phe Val Leu Pro Ser 
            180                 185                 190         
Ala Glu Lys Asp Met Cys Leu Gly Ala Gly Met Ala Ser Met Thr Gly 
        195                 200                 205             
Gly Gln Gln Met Gly Ala Ser Ser Asp Ser Asn Lys Gly Met Leu Gly 
    210                 215                 220                 
Leu Ile Val Tyr Leu Gly Met Met Val Gly Ala Phe Leu Trp Gly Gly 
225                 230                 235                 240 
Leu Ala Asp Arg Leu Gly Arg Arg Gln Cys Leu Leu Ile Ser Leu Ser 
                245                 250                 255     
Val Asn Ser Val Phe Ala Phe Phe Ser Ser Phe Val Gln Gly Tyr Gly 
            260                 265                 270         
Thr Phe Leu Phe Cys Arg Leu Leu Ser Gly Val Gly Ile Gly Gly Ser 
        275                 280                 285             
Ile Pro Ile Val Phe Ser Tyr Phe Ser Glu Phe Leu Ala Gln Glu Lys 
    290                 295                 300                 
Arg Gly Glu His Leu Ser Trp Leu Cys Met Phe Trp Met Ile Gly Gly 
305                 310                 315                 320 
Val Tyr Ala Ala Ala Met Ala Trp Ala Ile Ile Pro His Tyr Gly Trp 
                325                 330                 335     
Ser Phe Gln Met Gly Ser Ala Tyr Gln Phe His Ser Trp Arg Val Phe 
            340                 345                 350         
Val Leu Val Cys Ala Phe Pro Ser Val Phe Ala Ile Gly Ala Leu Thr 
        355                 360                 365             
Thr Gln Pro Glu Ser Pro Arg Phe Phe Leu Glu Asn Gly Lys His Asp 
    370                 375                 380                 
Glu Ala Trp Met Val Leu Lys Gln Val His Asp Thr Asn Met Arg Ala 
385                 390                 395                 400 
Lys Gly His Pro Glu Arg Val Phe Ser Val Thr His Ile Lys Thr Ile 
                405                 410                 415     
His Gln Glu Asp Glu Leu Ile Glu Ile Gln Ser Asp Thr Gly Thr Trp 
            420                 425                 430         
Tyr Gln Arg Trp Gly Val Arg Ala Leu Ser Leu Gly Gly Gln Val Trp 
        435                 440                 445             
Gly Asn Phe Leu Ser Cys Phe Gly Pro Glu Tyr Arg Arg Ile Thr Leu 
    450                 455                 460                 
Met Met Met Gly Val Trp Phe Thr Met Ser Phe Ser Tyr Tyr Gly Leu 
465                 470                 475                 480 
Thr Val Trp Phe Pro Asp Met Ile Arg His Leu Gln Ala Val Asp Tyr 
                485                 490                 495     
Ala Ser Arg Thr Lys Val Phe Pro Gly Glu Arg Val Glu His Val Thr 
            500                 505                 510         
Phe Asn Phe Thr Leu Glu Asn Gln Ile His Arg Gly Gly Gln Tyr Phe 
        515                 520                 525             
Asn Asp Lys Phe Ile Gly Leu Arg Leu Lys Ser Val Ser Phe Glu Asp 
    530                 535                 540                 
Ser Leu Phe Glu Glu Cys Tyr Phe Glu Asp Val Thr Ser Ser Asn Thr 
545                 550                 555                 560 
Phe Phe Arg Asn Cys Thr Phe Ile Asn Thr Val Phe Tyr Asn Thr Asp 
                565                 570                 575     
Leu Phe Glu Tyr Lys Phe Val Asn Ser Arg Leu Ile Asn Ser Thr Phe 
            580                 585                 590         
Leu His Asn Lys Glu Gly Cys Pro Leu Asp Val Thr Gly Thr Gly Glu 
        595                 600                 605             
Gly Ala Tyr Met Val Tyr Phe Val Ser Phe Leu Gly Thr Leu Ala Val 
    610                 615                 620                 
Leu Pro Gly Asn Ile Val Ser Ala Leu Leu Met Asp Lys Ile Gly Arg 
625                 630                 635                 640 
Leu Arg Met Leu Ala Gly Ser Ser Val Met Ser Cys Val Ser Cys Phe 
                645                 650                 655     
Phe Leu Ser Phe Gly Asn Ser Glu Ser Ala Met Ile Ala Leu Leu Cys 
            660                 665                 670         
Leu Phe Gly Gly Val Ser Ile Ala Ser Trp Asn Ala Leu Asp Val Leu 
        675                 680                 685             
Thr Val Glu Leu Tyr Pro Ser Asp Lys Arg Thr Thr Ala Phe Gly Phe 
    690                 695                 700                 
Leu Asn Ala Leu Cys Lys Leu Ala Ala Val Leu Gly Ile Ser Ile Phe 
705                 710                 715                 720 
Thr Ser Phe Val Gly Ile Thr Lys Ala Ala Pro Ile Leu Phe Ala Ser 
                725                 730                 735     
Ala Ala Leu Ala Leu Gly Ser Ser Leu Ala Leu Lys Leu Pro Glu Thr 
            740                 745                 750         
Arg Gly Gln Val Leu Gln Ser Arg Ala Gly Ala Pro His Phe Pro Glu 
        755                 760                 765             
Ile Ser Phe Pro Pro Lys Pro Asp Ser Asp Tyr Gln Ala Leu Leu Pro 
    770                 775                 780                 
Ser Ala Pro Glu Ile Tyr Ser His Leu Ser Pro Thr Lys Pro Asp Tyr 
785                 790                 795                 800 
Ile Asn Leu Arg Pro Ala Pro 
                805         

<210> 6
<211> 175
<212> PRT
<213> Homo sapiens

<400> 6
Ile Thr Leu Met Met Met Gly Val Trp Phe Thr Met Ser Phe Ser Tyr 
1               5                   10                  15      
Tyr Gly Leu Thr Val Trp Phe Pro Asp Met Ile Arg His Leu Gln Ala 
            20                  25                  30          
Val Asp Tyr Ala Ser Arg Thr Lys Val Phe Pro Gly Glu Arg Val Glu 
        35                  40                  45              
His Val Thr Phe Asn Phe Thr Leu Glu Asn Gln Ile His Arg Gly Gly 
    50                  55                  60                  
Gln Tyr Phe Asn Asp Lys Phe Ile Gly Leu Arg Leu Lys Ser Val Ser 
65                  70                  75                  80  
Phe Glu Asp Ser Leu Phe Glu Glu Cys Tyr Phe Glu Asp Val Thr Ser 
                85                  90                  95      
Ser Asn Thr Phe Phe Arg Asn Cys Thr Phe Ile Asn Thr Val Phe Tyr 
            100                 105                 110         
Asn Thr Asp Leu Phe Glu Tyr Lys Phe Val Asn Ser Arg Leu Ile Asn 
        115                 120                 125             
Ser Thr Phe Leu His Asn Lys Glu Gly Cys Pro Leu Asp Val Thr Gly 
    130                 135                 140                 
Thr Gly Glu Gly Ala Tyr Met Val Tyr Phe Val Ser Phe Leu Gly Thr 
145                 150                 155                 160 
Leu Ala Val Leu Pro Gly Asn Ile Val Ser Ala Leu Leu Met Asp 
                165                 170                 175 

<210> 7
<211> 2052
<212> DNA
<213> Homo sapiens

<400> 7
atggatgact acaagtatca ggacaattat gggggctatg ctcccagtga tggctattac      60

cgcggcaatg agtccaaccc agaagaagat gcacagagtg atgtcaccga aggccatgat     120

gaggaagacg agatctatga gggcgagtac cagggtatcc ctcacccaga tgatgtcaag     180

gccaagcagg ccaagatggc gccctccaga atggacagcc ttcggggcca gacagacctg     240

atggctgaga ggctggaaga tgaggagcag ttggcccacc agtacgagac catcatggat     300

gagtgtggcc atggccgctt ccagtggatc ctctttttcg tcttgggttt ggccctgatg     360

gccgatgggg tggaagtgtt cgtggtgagt tttgccctgc ccagtgcaga gaaggacatg     420

tgtctgtcca gttccaaaaa aggaatgcta gggatgatag tctacttggg aatgatggcg     480

ggcgccttca tcctgggagg cctggctgat aagctgggaa ggaagcgagt cctcagcatg     540

tctctggccg tcaatgcctc cttcgcctcc ctctcttcct tcgtgcaggg atatggagcc     600

ttcctcttct gccgactcat ctcaggcatc ggtattgggg gtgctctacc gattgttttt     660

gcctattttt ctgaattctt gtctcgggag aagcgaggag aacacctcag ttggctgggc     720

atcttctgga tgactggggg cctgtacgca tctgccatgg cctggagcat catcccacac     780

tatggctggg gcttcagcat ggggaccaat taccacttcc atagctggag agtgtttgtc     840

atcgtctgtg ctctgccctg caccgtgtcc atggtggccc tgaagttcat gccagagagc     900

ccaaggtttc tgctagagat gggcaaacat gatgaagcct ggatgattct caagcaagtc     960

catgacacca acatgagagc taaggggacc ccagagaaag tgttcacggt ttccaacatc    1020

aaaactccca agcaaatgga tgaattcatt gagatccaaa gttcaacagg aacctggtac    1080

cagcgctggc tggtcagatt caagaccatt ttcaagcagg tctgggataa tgccctgtac    1140

tgtgtgatgg ggccctacag aatgaataca ctgattctgg ccgtggtttg gtttgccatg    1200

gcattcagtt actatggact gacagtttgg tttcctgata tgatccgcta ttttcaagat    1260

gaagaataca agtctaaaat gaaggtgttt tttggtgagc atgtgtacgg cgccacaatc    1320

aacttcacga tggaaaatca gatccaccaa catgggaaac ttgtgaatga taagttcaca    1380

agaatgtact ttaaacatgt actctttgag gacacattct ttgacgagtg ctattttgaa    1440

gacgtaacat caacagatac ctacttcaaa aattgtacca ttgaatcaac catcttttac    1500

aacacagacc tctacgagca caagttcatc aactgtcggt ttatcaactc caccttcctg    1560

gagcagaagg agggctgcca catggacttg gagcaagata atgacttcct gatttacctc    1620

gtcagcttcc tgggcagcct gtctgtctta cccgggaaca tcatttctgc cctgctcatg    1680

gatagaattg gaaggctcaa gatgattggt ggctccatgc taatctctgc agtctgctgc    1740

ttcttcctgt tttttggcaa cagtgagtct gcaatgatcg gctggcagtg cctgttctgt    1800

gggacaagca ttgcagcctg gaatgctctg gatgtgatca cagtggagct gtatcccacc    1860

aaccagagag caacagcctt cggcattctc aatggattat gcaaatttgg cgccatcctg    1920

ggaaacacca tctttgcttc ttttgttggg ataaccaaag tggtccccat ccttctggct    1980

gctgcttctc tggttggggg tggcctgatt gcccttcgac tgccagagac tcgagaacag    2040

gtcctgatgt ga                                                        2052


<210> 8
<211> 683
<212> PRT
<213> Homo sapiens

<400> 8
Met Asp Asp Tyr Lys Tyr Gln Asp Asn Tyr Gly Gly Tyr Ala Pro Ser 
1               5                   10                  15      
Asp Gly Tyr Tyr Arg Gly Asn Glu Ser Asn Pro Glu Glu Asp Ala Gln 
            20                  25                  30          
Ser Asp Val Thr Glu Gly His Asp Glu Glu Asp Glu Ile Tyr Glu Gly 
        35                  40                  45              
Glu Tyr Gln Gly Ile Pro His Pro Asp Asp Val Lys Ala Lys Gln Ala 
    50                  55                  60                  
Lys Met Ala Pro Ser Arg Met Asp Ser Leu Arg Gly Gln Thr Asp Leu 
65                  70                  75                  80  
Met Ala Glu Arg Leu Glu Asp Glu Glu Gln Leu Ala His Gln Tyr Glu 
                85                  90                  95      
Thr Ile Met Asp Glu Cys Gly His Gly Arg Phe Gln Trp Ile Leu Phe 
            100                 105                 110         
Phe Val Leu Gly Leu Ala Leu Met Ala Asp Gly Val Glu Val Phe Val 
        115                 120                 125             
Val Ser Phe Ala Leu Pro Ser Ala Glu Lys Asp Met Cys Leu Ser Ser 
    130                 135                 140                 
Ser Lys Lys Gly Met Leu Gly Met Ile Val Tyr Leu Gly Met Met Ala 
145                 150                 155                 160 
Gly Ala Phe Ile Leu Gly Gly Leu Ala Asp Lys Leu Gly Arg Lys Arg 
                165                 170                 175     
Val Leu Ser Met Ser Leu Ala Val Asn Ala Ser Phe Ala Ser Leu Ser 
            180                 185                 190         
Ser Phe Val Gln Gly Tyr Gly Ala Phe Leu Phe Cys Arg Leu Ile Ser 
        195                 200                 205             
Gly Ile Gly Ile Gly Gly Ala Leu Pro Ile Val Phe Ala Tyr Phe Ser 
    210                 215                 220                 
Glu Phe Leu Ser Arg Glu Lys Arg Gly Glu His Leu Ser Trp Leu Gly 
225                 230                 235                 240 
Ile Phe Trp Met Thr Gly Gly Leu Tyr Ala Ser Ala Met Ala Trp Ser 
                245                 250                 255     
Ile Ile Pro His Tyr Gly Trp Gly Phe Ser Met Gly Thr Asn Tyr His 
            260                 265                 270         
Phe His Ser Trp Arg Val Phe Val Ile Val Cys Ala Leu Pro Cys Thr 
        275                 280                 285             
Val Ser Met Val Ala Leu Lys Phe Met Pro Glu Ser Pro Arg Phe Leu 
    290                 295                 300                 
Leu Glu Met Gly Lys His Asp Glu Ala Trp Met Ile Leu Lys Gln Val 
305                 310                 315                 320 
His Asp Thr Asn Met Arg Ala Lys Gly Thr Pro Glu Lys Val Phe Thr 
                325                 330                 335     
Val Ser Asn Ile Lys Thr Pro Lys Gln Met Asp Glu Phe Ile Glu Ile 
            340                 345                 350         
Gln Ser Ser Thr Gly Thr Trp Tyr Gln Arg Trp Leu Val Arg Phe Lys 
        355                 360                 365             
Thr Ile Phe Lys Gln Val Trp Asp Asn Ala Leu Tyr Cys Val Met Gly 
    370                 375                 380                 
Pro Tyr Arg Met Asn Thr Leu Ile Leu Ala Val Val Trp Phe Ala Met 
385                 390                 395                 400 
Ala Phe Ser Tyr Tyr Gly Leu Thr Val Trp Phe Pro Asp Met Ile Arg 
                405                 410                 415     
Tyr Phe Gln Asp Glu Glu Tyr Lys Ser Lys Met Lys Val Phe Phe Gly 
            420                 425                 430         
Glu His Val Tyr Gly Ala Thr Ile Asn Phe Thr Met Glu Asn Gln Ile 
        435                 440                 445             
His Gln His Gly Lys Leu Val Asn Asp Lys Phe Thr Arg Met Tyr Phe 
    450                 455                 460                 
Lys His Val Leu Phe Glu Asp Thr Phe Phe Asp Glu Cys Tyr Phe Glu 
465                 470                 475                 480 
Asp Val Thr Ser Thr Asp Thr Tyr Phe Lys Asn Cys Thr Ile Glu Ser 
                485                 490                 495     
Thr Ile Phe Tyr Asn Thr Asp Leu Tyr Glu His Lys Phe Ile Asn Cys 
            500                 505                 510         
Arg Phe Ile Asn Ser Thr Phe Leu Glu Gln Lys Glu Gly Cys His Met 
        515                 520                 525             
Asp Leu Glu Gln Asp Asn Asp Phe Leu Ile Tyr Leu Val Ser Phe Leu 
    530                 535                 540                 
Gly Ser Leu Ser Val Leu Pro Gly Asn Ile Ile Ser Ala Leu Leu Met 
545                 550                 555                 560 
Asp Arg Ile Gly Arg Leu Lys Met Ile Gly Gly Ser Met Leu Ile Ser 
                565                 570                 575     
Ala Val Cys Cys Phe Phe Leu Phe Phe Gly Asn Ser Glu Ser Ala Met 
            580                 585                 590         
Ile Gly Trp Gln Cys Leu Phe Cys Gly Thr Ser Ile Ala Ala Trp Asn 
        595                 600                 605             
Ala Leu Asp Val Ile Thr Val Glu Leu Tyr Pro Thr Asn Gln Arg Ala 
    610                 615                 620                 
Thr Ala Phe Gly Ile Leu Asn Gly Leu Cys Lys Phe Gly Ala Ile Leu 
625                 630                 635                 640 
Gly Asn Thr Ile Phe Ala Ser Phe Val Gly Ile Thr Lys Val Val Pro 
                645                 650                 655     
Ile Leu Leu Ala Ala Ala Ser Leu Val Gly Gly Gly Leu Ile Ala Leu 
            660                 665                 670         
Arg Leu Pro Glu Thr Arg Glu Gln Val Leu Met 
        675                 680             

<210> 9
<211> 183
<212> PRT
<213> Homo sapiens

<400> 9
Ala Leu Tyr Cys Val Met Gly Pro Tyr Arg Met Asn Thr Leu Ile Leu 
1               5                   10                  15      
Ala Val Val Trp Phe Ala Met Ala Phe Ser Tyr Tyr Gly Leu Thr Val 
            20                  25                  30          
Trp Phe Pro Asp Met Ile Arg Tyr Phe Gln Asp Glu Glu Tyr Lys Ser 
        35                  40                  45              
Lys Met Lys Val Phe Phe Gly Glu His Val Tyr Gly Ala Thr Ile Asn 
    50                  55                  60                  
Phe Thr Met Glu Asn Gln Ile His Gln His Gly Lys Leu Val Asn Asp 
65                  70                  75                  80  
Lys Phe Thr Arg Met Tyr Phe Lys His Val Leu Phe Glu Asp Thr Phe 
                85                  90                  95      
Phe Asp Glu Cys Tyr Phe Glu Asp Val Thr Ser Thr Asp Thr Tyr Phe 
            100                 105                 110         
Lys Asn Cys Thr Ile Glu Ser Thr Ile Phe Tyr Asn Thr Asp Leu Tyr 
        115                 120                 125             
Glu His Lys Phe Ile Asn Cys Arg Phe Ile Asn Ser Thr Phe Leu Glu 
    130                 135                 140                 
Gln Lys Glu Gly Cys His Met Asp Leu Glu Gln Asp Asn Asp Phe Leu 
145                 150                 155                 160 
Ile Tyr Leu Val Ser Phe Leu Gly Ser Leu Ser Val Leu Pro Gly Asn 
                165                 170                 175     
Ile Ile Ser Ala Leu Leu Met 
            180             

<210> 10
<211> 2184
<212> DNA
<213> Homo sapiens

<400> 10
atggaagact cttacaagga taggacttca ctgatgaagg gtgccaagga cattgccaga      60

gaggtgaaga aacaaacagt aaagaaggtg aatcaagctg tggaccgagc ccaggatgaa     120

tacacccaga ggtcctacag tcggttccaa gatgaagaag atgatgatga ctactacccg     180

gctggagaaa cctataatgg tgaggccaac gatgacgaag gctcaagtga agccactgag     240

gggcatgatg aagatgatga gatctatgag ggggagtatc agggcatccc cagtatgaac     300

caagcgaagg acagcatcgt gtcagtgggg cagcccaagg gcgatgagta caaggaccgg     360

cgggagctgg aatcagaaag gagagctgac gaggaagagt tagcccagca gtatgagctg     420

ataatccaag aatgcggtca tggtcgtttt cagtgggccc ttttcttcgt cctgggcatg     480

gctcttatgg cagacggtgt agaggtgttt gtcgttggct tcgtgttacc cagtgctgag     540

acagacctct gcatcccaaa ttcaggatct ggatggctag gcagcatagt gtacctcggg     600

atgatggtgg gggcgttctt ctggggagga ctggcagaca aagtgggaag gaaacagtct     660

cttctgattt gcatgtctgt caacggattc tttgccttcc tttcttcatt tgtccaaggt     720

tatggcttct ttctcttctg tcgcttactt tctggattcg ggattggagg agccataccc     780

actgtgttct cgtactttgc tgaagtcctg gcccgggaaa agcggggcga acacttgagc     840

tggctctgca tgttctggat gatcggtggc atctacgcct ctgccatggc ctgggccatc     900

atcccgcact acgggtggag cttcagcatg ggatcggcct accagtttca cagttggcgt     960

gtgtttgtca tcgtctgtgc actcccctgt gtctcctccg tggtggccct cacattcatg    1020

cctgaaagcc cacgattctt gttggaggtt ggaaaacatg atgaagcttg gatgattctg    1080

aagttaattc atgacaccaa catgagagcc cggggtcagc ctgagaaggt cttcacggta    1140

aacaaaataa aaactcctaa acaaatagat gagctgattg aaattgagag tgacacagga    1200

acatggtata ggaggtgttt tgttcggatc cgcaccgagc tgtacggaat ttggttgact    1260

tttatgagat gtttcaacta cccagtcagg gataatacaa taaagcttac aattgtttgg    1320

ttcaccctgt cctttgggta ctatggatta tccgtttggt tccctgatgt cattaaacct    1380

ctgcagtccg atgaatatgc attgctaacc agaaatgtgg agagagataa atatgcaaat    1440

ttcactatta actttacaat ggaaaatcag attcatactg gaatggaata cgacaatggc    1500

agattcatag gggtcaagtt caaatctgta actttcaaag actctgtttt taagtcctgc    1560

acctttgagg atgtaacttc agtgaacacc tacttcaaga actgcacatt tattgacact    1620

gtttttgaca acacagattt tgagccatat aaattcattg acagtgaatt taaaaactgc    1680

tcgttttttc acaacaagac gggatgtcag attacctttg atgatgacta tagtgcctac    1740

tggatttatt ttgtcaactt tctggggaca ttggcagtat tgccagggaa cattgtgtct    1800

gctctgctga tggacagaat tgggcgctta acaatgctag gtggctctat ggtgctttcg    1860

gggatcagct gtttcttcct ttggttcggc accagtgaat ccatgatgat aggcatgctg    1920

tgtctgtaca atggattgac catctcagcc tggaactctc ttgacgtggt cactgtggaa    1980

ctgtacccca cagaccggag ggcaacaggc tttggcttct taaatgcgct atgcaaggca    2040

gcagccgtcc tgggaaactt aatatttggc tctctggtca gcatcaccaa atcaatcccc    2100

atcctgctgg cttctactgt gctcgtgtgt ggaggactcg ttgggctgtg cctgcctgac    2160

acacgaaccc aggttctgat gtaa                                           2184


<210> 11
<211> 727
<212> PRT
<213> Homo sapiens

<400> 11
Met Glu Asp Ser Tyr Lys Asp Arg Thr Ser Leu Met Lys Gly Ala Lys 
1               5                   10                  15      
Asp Ile Ala Arg Glu Val Lys Lys Gln Thr Val Lys Lys Val Asn Gln 
            20                  25                  30          
Ala Val Asp Arg Ala Gln Asp Glu Tyr Thr Gln Arg Ser Tyr Ser Arg 
        35                  40                  45              
Phe Gln Asp Glu Glu Asp Asp Asp Asp Tyr Tyr Pro Ala Gly Glu Thr 
    50                  55                  60                  
Tyr Asn Gly Glu Ala Asn Asp Asp Glu Gly Ser Ser Glu Ala Thr Glu 
65                  70                  75                  80  
Gly His Asp Glu Asp Asp Glu Ile Tyr Glu Gly Glu Tyr Gln Gly Ile 
                85                  90                  95      
Pro Ser Met Asn Gln Ala Lys Asp Ser Ile Val Ser Val Gly Gln Pro 
            100                 105                 110         
Lys Gly Asp Glu Tyr Lys Asp Arg Arg Glu Leu Glu Ser Glu Arg Arg 
        115                 120                 125             
Ala Asp Glu Glu Glu Leu Ala Gln Gln Tyr Glu Leu Ile Ile Gln Glu 
    130                 135                 140                 
Cys Gly His Gly Arg Phe Gln Trp Ala Leu Phe Phe Val Leu Gly Met 
145                 150                 155                 160 
Ala Leu Met Ala Asp Gly Val Glu Val Phe Val Val Gly Phe Val Leu 
                165                 170                 175     
Pro Ser Ala Glu Thr Asp Leu Cys Ile Pro Asn Ser Gly Ser Gly Trp 
            180                 185                 190         
Leu Gly Ser Ile Val Tyr Leu Gly Met Met Val Gly Ala Phe Phe Trp 
        195                 200                 205             
Gly Gly Leu Ala Asp Lys Val Gly Arg Lys Gln Ser Leu Leu Ile Cys 
    210                 215                 220                 
Met Ser Val Asn Gly Phe Phe Ala Phe Leu Ser Ser Phe Val Gln Gly 
225                 230                 235                 240 
Tyr Gly Phe Phe Leu Phe Cys Arg Leu Leu Ser Gly Phe Gly Ile Gly 
                245                 250                 255     
Gly Ala Ile Pro Thr Val Phe Ser Tyr Phe Ala Glu Val Leu Ala Arg 
            260                 265                 270         
Glu Lys Arg Gly Glu His Leu Ser Trp Leu Cys Met Phe Trp Met Ile 
        275                 280                 285             
Gly Gly Ile Tyr Ala Ser Ala Met Ala Trp Ala Ile Ile Pro His Tyr 
    290                 295                 300                 
Gly Trp Ser Phe Ser Met Gly Ser Ala Tyr Gln Phe His Ser Trp Arg 
305                 310                 315                 320 
Val Phe Val Ile Val Cys Ala Leu Pro Cys Val Ser Ser Val Val Ala 
                325                 330                 335     
Leu Thr Phe Met Pro Glu Ser Pro Arg Phe Leu Leu Glu Val Gly Lys 
            340                 345                 350         
His Asp Glu Ala Trp Met Ile Leu Lys Leu Ile His Asp Thr Asn Met 
        355                 360                 365             
Arg Ala Arg Gly Gln Pro Glu Lys Val Phe Thr Val Asn Lys Ile Lys 
    370                 375                 380                 
Thr Pro Lys Gln Ile Asp Glu Leu Ile Glu Ile Glu Ser Asp Thr Gly 
385                 390                 395                 400 
Thr Trp Tyr Arg Arg Cys Phe Val Arg Ile Arg Thr Glu Leu Tyr Gly 
                405                 410                 415     
Ile Trp Leu Thr Phe Met Arg Cys Phe Asn Tyr Pro Val Arg Asp Asn 
            420                 425                 430         
Thr Ile Lys Leu Thr Ile Val Trp Phe Thr Leu Ser Phe Gly Tyr Tyr 
        435                 440                 445             
Gly Leu Ser Val Trp Phe Pro Asp Val Ile Lys Pro Leu Gln Ser Asp 
    450                 455                 460                 
Glu Tyr Ala Leu Leu Thr Arg Asn Val Glu Arg Asp Lys Tyr Ala Asn 
465                 470                 475                 480 
Phe Thr Ile Asn Phe Thr Met Glu Asn Gln Ile His Thr Gly Met Glu 
                485                 490                 495     
Tyr Asp Asn Gly Arg Phe Ile Gly Val Lys Phe Lys Ser Val Thr Phe 
            500                 505                 510         
Lys Asp Ser Val Phe Lys Ser Cys Thr Phe Glu Asp Val Thr Ser Val 
        515                 520                 525             
Asn Thr Tyr Phe Lys Asn Cys Thr Phe Ile Asp Thr Val Phe Asp Asn 
    530                 535                 540                 
Thr Asp Phe Glu Pro Tyr Lys Phe Ile Asp Ser Glu Phe Lys Asn Cys 
545                 550                 555                 560 
Ser Phe Phe His Asn Lys Thr Gly Cys Gln Ile Thr Phe Asp Asp Asp 
                565                 570                 575     
Tyr Ser Ala Tyr Trp Ile Tyr Phe Val Asn Phe Leu Gly Thr Leu Ala 
            580                 585                 590         
Val Leu Pro Gly Asn Ile Val Ser Ala Leu Leu Met Asp Arg Ile Gly 
        595                 600                 605             
Arg Leu Thr Met Leu Gly Gly Ser Met Val Leu Ser Gly Ile Ser Cys 
    610                 615                 620                 
Phe Phe Leu Trp Phe Gly Thr Ser Glu Ser Met Met Ile Gly Met Leu 
625                 630                 635                 640 
Cys Leu Tyr Asn Gly Leu Thr Ile Ser Ala Trp Asn Ser Leu Asp Val 
                645                 650                 655     
Val Thr Val Glu Leu Tyr Pro Thr Asp Arg Arg Ala Thr Gly Phe Gly 
            660                 665                 670         
Phe Leu Asn Ala Leu Cys Lys Ala Ala Ala Val Leu Gly Asn Leu Ile 
        675                 680                 685             
Phe Gly Ser Leu Val Ser Ile Thr Lys Ser Ile Pro Ile Leu Leu Ala 
    690                 695                 700                 
Ser Thr Val Leu Val Cys Gly Gly Leu Val Gly Leu Cys Leu Pro Asp 
705                 710                 715                 720 
Thr Arg Thr Gln Val Leu Met 
                725         

<210> 12
<211> 180
<212> PRT
<213> Homo sapiens

<400> 12
Met Arg Cys Phe Asn Tyr Pro Val Arg Asp Asn Thr Ile Lys Leu Thr 
1               5                   10                  15      
Ile Val Trp Phe Thr Leu Ser Phe Gly Tyr Tyr Gly Leu Ser Val Trp 
            20                  25                  30          
Phe Pro Asp Val Ile Lys Pro Leu Gln Ser Asp Glu Tyr Ala Leu Leu 
        35                  40                  45              
Thr Arg Asn Val Glu Arg Asp Lys Tyr Ala Asn Phe Thr Ile Asn Phe 
    50                  55                  60                  
Thr Met Glu Asn Gln Ile His Thr Gly Met Glu Tyr Asp Asn Gly Arg 
65                  70                  75                  80  
Phe Ile Gly Val Lys Phe Lys Ser Val Thr Phe Lys Asp Ser Val Phe 
                85                  90                  95      
Lys Ser Cys Thr Phe Glu Asp Val Thr Ser Val Asn Thr Tyr Phe Lys 
            100                 105                 110         
Asn Cys Thr Phe Ile Asp Thr Val Phe Asp Asn Thr Asp Phe Glu Pro 
        115                 120                 125             
Tyr Lys Phe Ile Asp Ser Glu Phe Lys Asn Cys Ser Phe Phe His Asn 
    130                 135                 140                 
Lys Thr Gly Cys Gln Ile Thr Phe Asp Asp Asp Tyr Ser Ala Tyr Trp 
145                 150                 155                 160 
Ile Tyr Phe Val Asn Phe Leu Gly Thr Leu Ala Val Leu Pro Gly Asn 
                165                 170                 175     
Ile Val Ser Ala 
            180 

<210> 13
<211> 1266
<212> DNA
<213> Rattus norvegicus

<400> 13
atggtgagtg ccagtcatcc tgaggccctg gccgcccctg tcaccactgt tgcgaccctt      60

gtcccacaca atgccactga gccagccagt cctggggaag ggaaggaaga tgccttttcc     120

aagctgaagc agaagtttat gaatgagctg cataaaattc cattgccacc gtgggcctta     180

atagccatag ccatagttgc ggtcctttta gtcgtaacct gctgcttttg tgtctgtaag     240

aaatgtttgt tcaaaaagaa aaacaagaag aaggggaagg aaaagggagg aaagaacgcc     300

attaacatga aagacgtgaa agacttaggg aagaccatga aggatcaggc ccttaaggat     360

gacgatgctg aaaccggact gactgatgga gaagaaaagg aagagcccaa ggaagaggag     420

aaactgggaa agctccaata ttcactggac tatgacttcc agaataacca gctgttggtg     480

ggaatcatcc aggctgctga actgcccgcc ctggacatgg ggggtacatc cgatccatac     540

gtcaaagtct tcctgctgcc tgacaaaaag aagaaatttg agactaaagt ccaccggaaa     600

accctcaatc cagtcttcaa tgaacaattt actttcaagg tgccctactc ggaattaggt     660

ggcaaaaccc tggtgatggc tgtgtatgac tttgatcgct tctccaagca tgacatcatc     720

ggagagttca aagttcctat gaacaccgtg gattttggcc atgtgaccga ggagtggcgt     780

gatctccaga gcgctgagaa agaagagcaa gagaaactgg gtgacatctg cttctccctc     840

cgctacgtcc ctactgccgg caaactgact gttgtcattc tggaagccaa gaacctgaag     900

aagatggatg tgggtggctt atctgatccc tacgtgaaga ttcacctgat gcagaacggt     960

aagaggctga agaagaaaaa gacgacgatt aagaagaaca cactcaaccc ctactacaac    1020

gagtccttca gctttgaagt tccgttcgag caaatccaga aagtgcaagt ggtggtaact    1080

gttttggact atgacaagat tggcaagaac gacgccatcg gcaaagtctt cgttggttac    1140

aacagcactg gggcggagct gcgacactgg tcagacatgc tggccaaccc ccggcgaccc    1200

atcgcacagt ggcacactct gcaggtagag gaggaggttg atgccatgct ggctgtcaag    1260

aagtaa                                                               1266


<210> 14
<211> 421
<212> PRT
<213> Rattus norvegicus

<400> 14
Met Val Ser Ala Ser His Pro Glu Ala Leu Ala Ala Pro Val Thr Thr 
1               5                   10                  15      
Val Ala Thr Leu Val Pro His Asn Ala Thr Glu Pro Ala Ser Pro Gly 
            20                  25                  30          
Glu Gly Lys Glu Asp Ala Phe Ser Lys Leu Lys Gln Lys Phe Met Asn 
        35                  40                  45              
Glu Leu His Lys Ile Pro Leu Pro Pro Trp Ala Leu Ile Ala Ile Ala 
    50                  55                  60                  
Ile Val Ala Val Leu Leu Val Val Thr Cys Cys Phe Cys Val Cys Lys 
65                  70                  75                  80  
Lys Cys Leu Phe Lys Lys Lys Asn Lys Lys Lys Gly Lys Glu Lys Gly 
                85                  90                  95      
Gly Lys Asn Ala Ile Asn Met Lys Asp Val Lys Asp Leu Gly Lys Thr 
            100                 105                 110         
Met Lys Asp Gln Ala Leu Lys Asp Asp Asp Ala Glu Thr Gly Leu Thr 
        115                 120                 125             
Asp Gly Glu Glu Lys Glu Glu Pro Lys Glu Glu Glu Lys Leu Gly Lys 
    130                 135                 140                 
Leu Gln Tyr Ser Leu Asp Tyr Asp Phe Gln Asn Asn Gln Leu Leu Val 
145                 150                 155                 160 
Gly Ile Ile Gln Ala Ala Glu Leu Pro Ala Leu Asp Met Gly Gly Thr 
                165                 170                 175     
Ser Asp Pro Tyr Val Lys Val Phe Leu Leu Pro Asp Lys Lys Lys Lys 
            180                 185                 190         
Phe Glu Thr Lys Val His Arg Lys Thr Leu Asn Pro Val Phe Asn Glu 
        195                 200                 205             
Gln Phe Thr Phe Lys Val Pro Tyr Ser Glu Leu Gly Gly Lys Thr Leu 
    210                 215                 220                 
Val Met Ala Val Tyr Asp Phe Asp Arg Phe Ser Lys His Asp Ile Ile 
225                 230                 235                 240 
Gly Glu Phe Lys Val Pro Met Asn Thr Val Asp Phe Gly His Val Thr 
                245                 250                 255     
Glu Glu Trp Arg Asp Leu Gln Ser Ala Glu Lys Glu Glu Gln Glu Lys 
            260                 265                 270         
Leu Gly Asp Ile Cys Phe Ser Leu Arg Tyr Val Pro Thr Ala Gly Lys 
        275                 280                 285             
Leu Thr Val Val Ile Leu Glu Ala Lys Asn Leu Lys Lys Met Asp Val 
    290                 295                 300                 
Gly Gly Leu Ser Asp Pro Tyr Val Lys Ile His Leu Met Gln Asn Gly 
305                 310                 315                 320 
Lys Arg Leu Lys Lys Lys Lys Thr Thr Ile Lys Lys Asn Thr Leu Asn 
                325                 330                 335     
Pro Tyr Tyr Asn Glu Ser Phe Ser Phe Glu Val Pro Phe Glu Gln Ile 
            340                 345                 350         
Gln Lys Val Gln Val Val Val Thr Val Leu Asp Tyr Asp Lys Ile Gly 
        355                 360                 365             
Lys Asn Asp Ala Ile Gly Lys Val Phe Val Gly Tyr Asn Ser Thr Gly 
    370                 375                 380                 
Ala Glu Leu Arg His Trp Ser Asp Met Leu Ala Asn Pro Arg Arg Pro 
385                 390                 395                 400 
Ile Ala Gln Trp His Thr Leu Gln Val Glu Glu Glu Val Asp Ala Met 
                405                 410                 415     
Leu Ala Val Lys Lys 
            420     

<210> 15
<211> 79
<212> PRT
<213> Rattus norvegicus

<400> 15
Met Val Ser Ala Ser His Pro Glu Ala Leu Ala Ala Pro Val Thr Thr 
1               5                   10                  15      
Val Ala Thr Leu Val Pro His Asn Ala Thr Glu Pro Ala Ser Pro Gly 
            20                  25                  30          
Glu Gly Lys Glu Asp Ala Phe Ser Lys Leu Lys Gln Lys Phe Met Asn 
        35                  40                  45              
Glu Leu His Lys Ile Pro Leu Pro Pro Trp Ala Leu Ile Ala Ile Ala 
    50                  55                  60                  
Ile Val Ala Val Leu Leu Val Val Thr Cys Cys Phe Cys Val Cys 
65                  70                  75                  

<210> 16
<211> 1413
<212> DNA
<213> Homo sapiens

<400> 16
atggtgtccg aatcccatca tgaagctctg gctgcaccac cagtcactac tgtcgcaaca      60

gtgctgcctt ccaatgctac agagccagct tcccctgggg aggggaagga ggatgctttc     120

agcaaactga aggagaagtt catgaacgaa ctgcacaaga tccctctgcc accatgggcc     180

ctgattgcta tcgccattgt cgcagtgctg ctggtcctga cctgttgttt ctgtatttgc     240

aagaagtgtc tgttcaagaa gaagaataag aagaagggaa aggagaaagg cggaaagaac     300

gctatcaata tgaaggacgt caaggatctg ggaaagacta tgaaggacca ggctctgaag     360

gacgacgacg ctgaaacagg cctgacagac ggcgaagaga aggaagagcc aaaggaggag     420

gagaagctgg ggaagctgca gtattccctg gactatgact tccagaacaa ccagctgctg     480

gtcggaatta ttcaagctgc agaactgcca gctctggaca tgggcggcac cagcgaccct     540

tacgtgaagg tctttctgct gccagataag aagaagaaat ttgagaccaa agtccacagg     600

aaaaccctga acccagtgtt caatgagcag ttcactttca aagtgccata cagcgagctg     660

ggcggaaaga ctctggtcat ggctgtgtat gatttcgata ggttctccaa gcacgacatt     720

atcggagaat tcaaggtgcc aatgaatact gtggatttcg ggcacgtcac tgaagaatgg     780

agagatctgc agagcgctga aaaggaagaa caagagaaac tgggcgacat ctgctttagc     840

ctgagatatg tccctaccgc tggcaagctg accgtcgtca ttctggaggc taagaatctg     900

aagaagatgg acgtgggagg actgtccgac ccatatgtca agatccatct gatgcaaaat     960

ggcaagaggc tgaagaagaa gaagactact attaagaaga acactctgaa cccctactat    1020

aacgaatcct tcagctttga agtcccattc gagcagattc aaaaggtcca agtcgtcgtc    1080

actgtcctgg attacgacaa gattggaaag aacgatgcca tcgggaaggt gttcgtcggc    1140

tacaacagca ctggcgcaga actgagacat tggagcgaca tgctggctaa tcctcggcgg    1200

cctatcgcac agtggcatac cctgcaagtg gaggaggaag tcgatgctat gctggctgtg    1260

aagaaatcta gaggcgcgcc ccacttccct gaaatctcct tcccccctaa acccgattct    1320

gattatcagg ccttgctacc atccgcgcca gagatctact ctcacctctc ccccaccaaa    1380

cccgattaca tcaaccttcg accggcgccc taa                                 1413


<210> 17
<211> 470
<212> PRT
<213> Homo sapiens

<400> 17
Met Val Ser Glu Ser His His Glu Ala Leu Ala Ala Pro Pro Val Thr 
1               5                   10                  15      
Thr Val Ala Thr Val Leu Pro Ser Asn Ala Thr Glu Pro Ala Ser Pro 
            20                  25                  30          
Gly Glu Gly Lys Glu Asp Ala Phe Ser Lys Leu Lys Glu Lys Phe Met 
        35                  40                  45              
Asn Glu Leu His Lys Ile Pro Leu Pro Pro Trp Ala Leu Ile Ala Ile 
    50                  55                  60                  
Ala Ile Val Ala Val Leu Leu Val Leu Thr Cys Cys Phe Cys Ile Cys 
65                  70                  75                  80  
Lys Lys Cys Leu Phe Lys Lys Lys Asn Lys Lys Lys Gly Lys Glu Lys 
                85                  90                  95      
Gly Gly Lys Asn Ala Ile Asn Met Lys Asp Val Lys Asp Leu Gly Lys 
            100                 105                 110         
Thr Met Lys Asp Gln Ala Leu Lys Asp Asp Asp Ala Glu Thr Gly Leu 
        115                 120                 125             
Thr Asp Gly Glu Glu Lys Glu Glu Pro Lys Glu Glu Glu Lys Leu Gly 
    130                 135                 140                 
Lys Leu Gln Tyr Ser Leu Asp Tyr Asp Phe Gln Asn Asn Gln Leu Leu 
145                 150                 155                 160 
Val Gly Ile Ile Gln Ala Ala Glu Leu Pro Ala Leu Asp Met Gly Gly 
                165                 170                 175     
Thr Ser Asp Pro Tyr Val Lys Val Phe Leu Leu Pro Asp Lys Lys Lys 
            180                 185                 190         
Lys Phe Glu Thr Lys Val His Arg Lys Thr Leu Asn Pro Val Phe Asn 
        195                 200                 205             
Glu Gln Phe Thr Phe Lys Val Pro Tyr Ser Glu Leu Gly Gly Lys Thr 
    210                 215                 220                 
Leu Val Met Ala Val Tyr Asp Phe Asp Arg Phe Ser Lys His Asp Ile 
225                 230                 235                 240 
Ile Gly Glu Phe Lys Val Pro Met Asn Thr Val Asp Phe Gly His Val 
                245                 250                 255     
Thr Glu Glu Trp Arg Asp Leu Gln Ser Ala Glu Lys Glu Glu Gln Glu 
            260                 265                 270         
Lys Leu Gly Asp Ile Cys Phe Ser Leu Arg Tyr Val Pro Thr Ala Gly 
        275                 280                 285             
Lys Leu Thr Val Val Ile Leu Glu Ala Lys Asn Leu Lys Lys Met Asp 
    290                 295                 300                 
Val Gly Gly Leu Ser Asp Pro Tyr Val Lys Ile His Leu Met Gln Asn 
305                 310                 315                 320 
Gly Lys Arg Leu Lys Lys Lys Lys Thr Thr Ile Lys Lys Asn Thr Leu 
                325                 330                 335     
Asn Pro Tyr Tyr Asn Glu Ser Phe Ser Phe Glu Val Pro Phe Glu Gln 
            340                 345                 350         
Ile Gln Lys Val Gln Val Val Val Thr Val Leu Asp Tyr Asp Lys Ile 
        355                 360                 365             
Gly Lys Asn Asp Ala Ile Gly Lys Val Phe Val Gly Tyr Asn Ser Thr 
    370                 375                 380                 
Gly Ala Glu Leu Arg His Trp Ser Asp Met Leu Ala Asn Pro Arg Arg 
385                 390                 395                 400 
Pro Ile Ala Gln Trp His Thr Leu Gln Val Glu Glu Glu Val Asp Ala 
                405                 410                 415     
Met Leu Ala Val Lys Lys Ser Arg Gly Ala Pro His Phe Pro Glu Ile 
            420                 425                 430         
Ser Phe Pro Pro Lys Pro Asp Ser Asp Tyr Gln Ala Leu Leu Pro Ser 
        435                 440                 445             
Ala Pro Glu Ile Tyr Ser His Leu Ser Pro Thr Lys Pro Asp Tyr Ile 
    450                 455                 460                 
Asn Leu Arg Pro Ala Pro 
465                 470 

<210> 18
<211> 80
<212> PRT
<213> Homo sapiens

<400> 18
Met Val Ser Glu Ser His His Glu Ala Leu Ala Ala Pro Pro Val Thr 
1               5                   10                  15      
Thr Val Ala Thr Val Leu Pro Ser Asn Ala Thr Glu Pro Ala Ser Pro 
            20                  25                  30          
Gly Glu Gly Lys Glu Asp Ala Phe Ser Lys Leu Lys Glu Lys Phe Met 
        35                  40                  45              
Asn Glu Leu His Lys Ile Pro Leu Pro Pro Trp Ala Leu Ile Ala Ile 
    50                  55                  60                  
Ala Ile Val Ala Val Leu Leu Val Leu Thr Cys Cys Phe Cys Ile Cys 
65                  70                  75                  80  



<210> 19
<211> 1416
<212> DNA
<213> Rattus norvegicus

<400> 19
atgaggaaca tcttcaagag aaaccaggaa cctattgtgg caccagctac cactactgca      60

acaatgcctc tcgctccagc agcccctgct gacaatagca ctgaatccac aggaactgga     120

gaaagccagg aagacatgtt tgccaagctt aaggataaat tctttaacga gatcaacaaa     180

atccctctgc caccttgggc tctcatcgcc atggcagtcg tggccggcct gctcctcctc     240

acttgctgct tctgtatctg caagaagtgt tgttgcaaga agaagaagaa taagaaagag     300

aagggcaagg gaatgaagaa cgccatgaat atgaaggaca tgaaaggcgg acaggatgat     360

gatgacgctg aaaccggtct caccgagggt gagggcgagg gtgaagagga gaaggaacca     420

gaaaatttag gtaaactcca gttcagcctg gactacgatt tccaagctaa ccaattaacc     480

gttggcgtac ttcaggctgc ggaactccca gccttggaca tgggtggaac gtcagacccc     540

tacgtcaagg tctttctttt gccagataag aagaagaagt atgaaacaaa ggtccataga     600

aagaccttaa acccagcttt caatgaaaca tttaccttta aagtccccta tcaggagtta     660

ggagggaaaa cacttgttat ggctatttat gatttcgaca gattttctaa gcacgacatt     720

atcggggaag tcaaagtgcc tatgaatact gtagatcttg ggcagccaat tgaagagtgg     780

cgagaccttc aaggcggcga aaaggaagaa ccagagaagt tgggagacat ctgcacctca     840

ctccgctatg tgcctactgc cggcaagcta actgtttgca tcttggaagc taagaatttg     900

aagaaaatgg acgtgggagg gttgagtgat ccatatgtga aaatacacct aatgcaaaac     960

gggaaacgtc ttaagaagaa gaaaacaacg gtaaagaaga agacgttgaa cccatatttc    1020

aatgaatcat tctccttcga gatacctttc gagcagatcc agaaagtgca agtagtggtg    1080

acagtattgg actacgacaa gctgggaaag aacgaggcta tagggaagat attcgtcggt    1140

tcgaatgcga caggcacaga gttacggcat tggtccgata tgttggccaa tccgagaaga    1200

ccgatagctc aatggcactc tctgaaacca gaagaggagg tggatgcctt acttggcaag    1260

aacaagtctc gcgctggcgc gccccacttc cctgaaatct ccttcccccc taaacccgat    1320

tctgattatc aggccttgct accatccgcg ccagagatct actctcacct ctcccccacc    1380

aaacccgatt acatcaacct tcgaccggcg ccctaa                              1416


<210> 20
<211> 471
<212> PRT
<213> Rattus norvegicus

<400> 20
Met Arg Asn Ile Phe Lys Arg Asn Gln Glu Pro Ile Val Ala Pro Ala 
1               5                   10                  15      
Thr Thr Thr Ala Thr Met Pro Leu Ala Pro Ala Ala Pro Ala Asp Asn 
            20                  25                  30          
Ser Thr Glu Ser Thr Gly Thr Gly Glu Ser Gln Glu Asp Met Phe Ala 
        35                  40                  45              
Lys Leu Lys Asp Lys Phe Phe Asn Glu Ile Asn Lys Ile Pro Leu Pro 
    50                  55                  60                  
Pro Trp Ala Leu Ile Ala Met Ala Val Val Ala Gly Leu Leu Leu Leu 
65                  70                  75                  80  
Thr Cys Cys Phe Cys Ile Cys Lys Lys Cys Cys Cys Lys Lys Lys Lys 
                85                  90                  95      
Asn Lys Lys Glu Lys Gly Lys Gly Met Lys Asn Ala Met Asn Met Lys 
            100                 105                 110         
Asp Met Lys Gly Gly Gln Asp Asp Asp Asp Ala Glu Thr Gly Leu Thr 
        115                 120                 125             
Glu Gly Glu Gly Glu Gly Glu Glu Glu Lys Glu Pro Glu Asn Leu Gly 
    130                 135                 140                 
Lys Leu Gln Phe Ser Leu Asp Tyr Asp Phe Gln Ala Asn Gln Leu Thr 
145                 150                 155                 160 
Val Gly Val Leu Gln Ala Ala Glu Leu Pro Ala Leu Asp Met Gly Gly 
                165                 170                 175     
Thr Ser Asp Pro Tyr Val Lys Val Phe Leu Leu Pro Asp Lys Lys Lys 
            180                 185                 190         
Lys Tyr Glu Thr Lys Val His Arg Lys Thr Leu Asn Pro Ala Phe Asn 
        195                 200                 205             
Glu Thr Phe Thr Phe Lys Val Pro Tyr Gln Glu Leu Gly Gly Lys Thr 
    210                 215                 220                 
Leu Val Met Ala Ile Tyr Asp Phe Asp Arg Phe Ser Lys His Asp Ile 
225                 230                 235                 240 
Ile Gly Glu Val Lys Val Pro Met Asn Thr Val Asp Leu Gly Gln Pro 
                245                 250                 255     
Ile Glu Glu Trp Arg Asp Leu Gln Gly Gly Glu Lys Glu Glu Pro Glu 
            260                 265                 270         
Lys Leu Gly Asp Ile Cys Thr Ser Leu Arg Tyr Val Pro Thr Ala Gly 
        275                 280                 285             
Lys Leu Thr Val Cys Ile Leu Glu Ala Lys Asn Leu Lys Lys Met Asp 
    290                 295                 300                 
Val Gly Gly Leu Ser Asp Pro Tyr Val Lys Ile His Leu Met Gln Asn 
305                 310                 315                 320 
Gly Lys Arg Leu Lys Lys Lys Lys Thr Thr Val Lys Lys Lys Thr Leu 
                325                 330                 335     
Asn Pro Tyr Phe Asn Glu Ser Phe Ser Phe Glu Ile Pro Phe Glu Gln 
            340                 345                 350         
Ile Gln Lys Val Gln Val Val Val Thr Val Leu Asp Tyr Asp Lys Leu 
        355                 360                 365             
Gly Lys Asn Glu Ala Ile Gly Lys Ile Phe Val Gly Ser Asn Ala Thr 
    370                 375                 380                 
Gly Thr Glu Leu Arg His Trp Ser Asp Met Leu Ala Asn Pro Arg Arg 
385                 390                 395                 400 
Pro Ile Ala Gln Trp His Ser Leu Lys Pro Glu Glu Glu Val Asp Ala 
                405                 410                 415     
Leu Leu Gly Lys Asn Lys Ser Arg Ala Gly Ala Pro His Phe Pro Glu 
            420                 425                 430         
Ile Ser Phe Pro Pro Lys Pro Asp Ser Asp Tyr Gln Ala Leu Leu Pro 
        435                 440                 445             
Ser Ala Pro Glu Ile Tyr Ser His Leu Ser Pro Thr Lys Pro Asp Tyr 
    450                 455                 460                 
Ile Asn Leu Arg Pro Ala Pro 
465                 470     

<210> 21
<211> 87
<212> PRT
<213> Rattus norvegicus

<400> 21
Met Arg Asn Ile Phe Lys Arg Asn Gln Glu Pro Ile Val Ala Pro Ala 
1               5                   10                  15      
Thr Thr Thr Ala Thr Met Pro Leu Ala Pro Ala Ala Pro Ala Asp Asn 
            20                  25                  30          
Ser Thr Glu Ser Thr Gly Thr Gly Glu Ser Gln Glu Asp Met Phe Ala 
        35                  40                  45              
Lys Leu Lys Asp Lys Phe Phe Asn Glu Ile Asn Lys Ile Pro Leu Pro 
    50                  55                  60                  
Pro Trp Ala Leu Ile Ala Met Ala Val Val Ala Gly Leu Leu Leu Leu 
65                  70                  75                  80  
Thr Cys Cys Phe Cys Ile Cys 
                85          

<210> 22
<211> 1407
<212> DNA
<213> Homo sapiens

<400> 22
atgcgtaata tcttcaagcg aaaccaggag cccatagtcg caccagccac aacaacggca      60

actatgccaa taggcccagt agataattcg acagagtcag gaggcgccgg agaatcacaa     120

gaggatatgt tcgccaagct caaggagaag ctgttcaatg aaatcaataa gattccgctc     180

cctccttggg ccctcattgc cattgcggta gtggccggat tgttgctgct cacttgttgc     240

ttctgcatct gtaagaagtg ttgttgcaag aagaagaaga acaagaaaga gaagggaaag     300

gggatgaaga atgcaatgaa tatgaaggat atgaagggag gccaagatga tgacgatgcg     360

gaaaccggtc tcaccgaggg tgagggcgag ggtgaagagg agaaggaacc agaaaattta     420

ggtaaactcc agttcagcct ggactacgat ttccaagcta accaattaac cgttggcgta     480

cttcaggctg cggaactccc agccttggac atgggtggaa cgtcagaccc ctacgtcaag     540

gtctttcttt tgccagataa gaagaagaag tatgaaacaa aggtccatag aaagacctta     600

aacccagctt tcaatgaaac atttaccttt aaagtcccct atcaggagtt aggagggaaa     660

acacttgtta tggctattta tgatttcgac agattttcta agcacgacat tatcggggaa     720

gtcaaagtgc ctatgaatac tgtagatctt gggcagccaa ttgaagagtg gcgagacctt     780

caaggcggcg aaaaggaaga accagagaag ttgggagaca tctgcacctc actccgctat     840

gtgcctactg ccggcaagct aactgtttgc atcttggaag ctaagaattt gaagaaaatg     900

gacgtgggag ggttgagtga tccatatgtg aaaatacacc taatgcaaaa cgggaaacgt     960

cttaagaaga agaaaacaac ggtaaagaag aagacgttga acccatattt caatgaatca    1020

ttctccttcg agataccttt cgagcagatc cagaaagtgc aagtagtggt gacagtattg    1080

gactacgaca agctgggaaa gaacgaggct atagggaaga tattcgtcgg ttcgaatgcg    1140

acaggcacag agttacggca ttggtccgat atgttggcca atccgagaag accgatagct    1200

caatggcact ctctgaaacc agaagaggag gtggatgcct tacttggcaa gaacaagtct    1260

cgcgctggcg cgccccactt ccctgaaatc tccttccccc ctaaacccga ttctgattat    1320

caggccttgc taccatccgc gccagagatc tactctcacc tctcccccac caaacccgat    1380

tacatcaacc ttcgaccggc gccctag                                        1407


<210> 23
<211> 468
<212> PRT
<213> Homo sapiens

<400> 23
Met Arg Asn Ile Phe Lys Arg Asn Gln Glu Pro Ile Val Ala Pro Ala 
1               5                   10                  15      
Thr Thr Thr Ala Thr Met Pro Ile Gly Pro Val Asp Asn Ser Thr Glu 
            20                  25                  30          
Ser Gly Gly Ala Gly Glu Ser Gln Glu Asp Met Phe Ala Lys Leu Lys 
        35                  40                  45              
Glu Lys Leu Phe Asn Glu Ile Asn Lys Ile Pro Leu Pro Pro Trp Ala 
    50                  55                  60                  
Leu Ile Ala Ile Ala Val Val Ala Gly Leu Leu Leu Leu Thr Cys Cys 
65                  70                  75                  80  
Phe Cys Ile Cys Lys Lys Cys Cys Cys Lys Lys Lys Lys Asn Lys Lys 
                85                  90                  95      
Glu Lys Gly Lys Gly Met Lys Asn Ala Met Asn Met Lys Asp Met Lys 
            100                 105                 110         
Gly Gly Gln Asp Asp Asp Asp Ala Glu Thr Gly Leu Thr Glu Gly Glu 
        115                 120                 125             
Gly Glu Gly Glu Glu Glu Lys Glu Pro Glu Asn Leu Gly Lys Leu Gln 
    130                 135                 140                 
Phe Ser Leu Asp Tyr Asp Phe Gln Ala Asn Gln Leu Thr Val Gly Val 
145                 150                 155                 160 
Leu Gln Ala Ala Glu Leu Pro Ala Leu Asp Met Gly Gly Thr Ser Asp 
                165                 170                 175     
Pro Tyr Val Lys Val Phe Leu Leu Pro Asp Lys Lys Lys Lys Tyr Glu 
            180                 185                 190         
Thr Lys Val His Arg Lys Thr Leu Asn Pro Ala Phe Asn Glu Thr Phe 
        195                 200                 205             
Thr Phe Lys Val Pro Tyr Gln Glu Leu Gly Gly Lys Thr Leu Val Met 
    210                 215                 220                 
Ala Ile Tyr Asp Phe Asp Arg Phe Ser Lys His Asp Ile Ile Gly Glu 
225                 230                 235                 240 
Val Lys Val Pro Met Asn Thr Val Asp Leu Gly Gln Pro Ile Glu Glu 
                245                 250                 255     
Trp Arg Asp Leu Gln Gly Gly Glu Lys Glu Glu Pro Glu Lys Leu Gly 
            260                 265                 270         
Asp Ile Cys Thr Ser Leu Arg Tyr Val Pro Thr Ala Gly Lys Leu Thr 
        275                 280                 285             
Val Cys Ile Leu Glu Ala Lys Asn Leu Lys Lys Met Asp Val Gly Gly 
    290                 295                 300                 
Leu Ser Asp Pro Tyr Val Lys Ile His Leu Met Gln Asn Gly Lys Arg 
305                 310                 315                 320 
Leu Lys Lys Lys Lys Thr Thr Val Lys Lys Lys Thr Leu Asn Pro Tyr 
                325                 330                 335     
Phe Asn Glu Ser Phe Ser Phe Glu Ile Pro Phe Glu Gln Ile Gln Lys 
            340                 345                 350         
Val Gln Val Val Val Thr Val Leu Asp Tyr Asp Lys Leu Gly Lys Asn 
        355                 360                 365             
Glu Ala Ile Gly Lys Ile Phe Val Gly Ser Asn Ala Thr Gly Thr Glu 
    370                 375                 380                 
Leu Arg His Trp Ser Asp Met Leu Ala Asn Pro Arg Arg Pro Ile Ala 
385                 390                 395                 400 
Gln Trp His Ser Leu Lys Pro Glu Glu Glu Val Asp Ala Leu Leu Gly 
                405                 410                 415     
Lys Asn Lys Ser Arg Ala Gly Ala Pro His Phe Pro Glu Ile Ser Phe 
            420                 425                 430         
Pro Pro Lys Pro Asp Ser Asp Tyr Gln Ala Leu Leu Pro Ser Ala Pro 
        435                 440                 445             
Glu Ile Tyr Ser His Leu Ser Pro Thr Lys Pro Asp Tyr Ile Asn Leu 
    450                 455                 460                 
Arg Pro Ala Pro 
465             

<210> 24
<211> 84
<212> PRT
<213> Homo sapiens

<400> 24
Met Arg Asn Ile Phe Lys Arg Asn Gln Glu Pro Ile Val Ala Pro Ala 
1               5                   10                  15      
Thr Thr Thr Ala Thr Met Pro Ile Gly Pro Val Asp Asn Ser Thr Glu 
            20                  25                  30          
Ser Gly Gly Ala Gly Glu Ser Gln Glu Asp Met Phe Ala Lys Leu Lys 
        35                  40                  45              
Glu Lys Leu Phe Asn Glu Ile Asn Lys Ile Pro Leu Pro Pro Trp Ala 
    50                  55                  60                  
Leu Ile Ala Ile Ala Val Val Ala Gly Leu Leu Leu Leu Thr Cys Cys 
65                  70                  75                  80  
Phe Cys Ile Cys 
                

<210> 25
<211> 49
<212> PRT
<213> Artificial Sequence

<220> 
<223> targeting signal version 1

<400> 25
Ser Arg Ala Gly Ala Pro His Phe Pro Glu Ile Ser Phe Pro Pro Lys 
1               5                   10                  15      
Pro Asp Ser Asp Tyr Gln Ala Leu Leu Pro Ser Ala Pro Glu Ile Tyr 
            20                  25                  30          
Ser His Leu Ser Pro Thr Lys Pro Asp Tyr Ile Asn Leu Arg Pro Ala 
        35                  40                  45              
Pro 
    

<210> 26
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> T7 Tag Peptide

<400> 26
Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly 
1               5                   10      

<210> 27
<211> 4444
<212> DNA
<213> Artificial Sequence

<220> 
<223> Nucleic sequence of the recipient vector

<400> 27
ctcttccgct tcctcgctca ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt       60

atcagctcac tcaaaggcgg taatacggtt atccacagaa tcaggggata acgcaggaaa      120

gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc      180

gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag      240

gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt      300

gcgctctcct gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg      360

aagcgtggcg ctttctcata gctcacgctg taggtatctc agttcggtgt aggtcgttcg      420

ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg ccttatccgg      480

taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac      540

tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg      600

gcctaactac ggctacacta gaagaacagt atttggtatc tgcgctctgc tgaagccagt      660

taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg      720

tggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc      780

tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt      840

ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt      900

taaatcaatc taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag      960

tgaggcacct atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccccgt     1020

cgtgtagata actacgatac gggagggctt accatctggc cccagtgctg caatgatacc     1080

gcgagaccca cgctcaccgg ctccagattt atcagcaata aaccagccag ccggaagggc     1140

cgagcgcaga agtggtcctg caactttatc cgcctccatc cagtctatta attgttgccg     1200

ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg ccattgctac     1260

aggcatcgtg gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg gttcccaacg     1320

atcaaggcga gttacatgat cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc     1380

tccgatcgtt gtcagaagta agttggccgc agtgttatca ctcatggtta tggcagcact     1440

gcataattct cttactgtca tgccatccgt aagatgcttt tctgtgactg gtgagtactc     1500

aaccaagtca ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaat     1560

acgggataat accgcgccac atagcagaac tttaaaagtg ctcatcattg gaaaacgttc     1620

ttcggggcga aaactctcaa ggatcttacc gctgttgaga tccagttcga tgtaacccac     1680

tcgtgcaccc aactgatctt cagcatcttt tactttcacc agcgtttctg ggtgagcaaa     1740

aacaggaagg caaaatgccg caaaaaaggg aataagggcg acacggaaat gttgaatact     1800

catactcttc ctttttcaat attattgaag catttatcag ggttattgtc tcatgagcgg     1860

atacatattt gaatgtattt agaaaaataa acaaataggg gttccgcgca catttccccg     1920

aaaagtgcca cctgacgtcg aattcaagat ctgttgacat tgattattga ctagttatta     1980

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata     2040

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat     2100

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga     2160

gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc     2220

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt     2280

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat     2340

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag     2400

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc     2460

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga     2520

ggtctatata agcagagctc gtttagtgaa ccgtcagata agcttctcgc atctctcctt     2580

cacgcgcccg ccgccctacc tgaggccgcc atccacgccg gttgagtcgc gttctgccgc     2640

ctcccgcctg tggtgcctcc tgaactgcgt ccgccgtcta ggtaagttta aagctcaggt     2700

cgagaccggg cctttgtccg gcgctccctt ggagcctacc tagactcagc cggctctcca     2760

cgctttgcct gaccctgctt gctcaactct agttctctcg ttaacttaat gagacagata     2820

gaaactggtc ttgtagaaac agagtagtcg cctgcttttc tgccaggtgc tgacttctct     2880

cccctgggct tttttctttt tctcaggttg aaaagaagaa gacgaagaag acgaagaaga     2940

caaagccgct taattaagat atcgctagcc accgcggccg cttagataac tgaatgcatc     3000

tagggcggcc aattccgccc ctctcccccc cccccttttc cctccccccc ccctaacgtt     3060

actggccgaa gccgcttgga ataaggccgg tgtgcgtttg tctatatgtt attttccacc     3120

atattgccgt cttttggcaa tgtgagggcc cggaaacctg gccctgtctt cttgacgagc     3180

attcctaggg gtctttcccc tctcgccaaa ggaatgcaag gtctgttgaa tgtcgtgaag     3240

gaagcagttc ctctggaagc ttcttgaaga caaacaacgt ctgtagcgac cctttgcagg     3300

cagcggaacc ccccacctgg cgacaggtgc ctctgcggcc aaaagccacg tgtataagat     3360

acacctgcaa aggcggcaca accccagtgc cacgttgtga gttggatagt tgtggaaaga     3420

gtcaaatggc tctcctcaag cgtattcaac aaggggctga aggatgccca gaaggtaccc     3480

cattgtatgg gatctgatct ggggcctcgg tgcacatgct ttacatgtgt ttagtcgagg     3540

ttaaaaaaac gtctaggccc cccgaaccac ggggacgtgg ttttcctttg aaaaacacga     3600

tgataagctt gccacaaccc gggaacatgg ccaagttgac cagtgctgtc ccagtgctca     3660

cagccaggga tgtggctgga gctgttgagt tctggactga caggttgggg ttctccagag     3720

attttgtgga ggatgacttt gcaggtgtgg tcagagatga tgtcaccctg ttcatctcag     3780

cagtccagga ccaggtggtg cctgacaaca ccctggcttg ggtgtgggtg agaggactgg     3840

atgagctgta tgctgagtgg agtgaggtgg tctccaccaa cttcagggat gccagtggcc     3900

ctgccatgac agagattgga gagcagccct gggggagaga gtttgccctg agagacccag     3960

caggcaactg tgtgcacttt gtggcagagg agcaggactg ataggcaatt gcgactgtgc     4020

cttctagttg ccagccatct gttgtttgcc cctcccccgt gccttccttg accctggaag     4080

gtgccactcc cactgtcctt tcctaataaa atgaggaaat tgcatcgcat tgtctgagta     4140

ggtgtcattc tattctgggg ggtggggtgg ggcaggacag caagggggag gattgggaag     4200

acaatagcag gcatgctggg gatgcggtgg gctctatggc tcgaggtgca aaaggagagc     4260

ctgtaagcgg gcactcttcc gtggtctggt ggataaattc gcaagggtat catggcggac     4320

gaccggggtt cgaaccccgg atccggccgt ccgccgtgat ccatgcggtt accgcccgcg     4380

tgtcgaaccc aggtgtgcga cgtcagacaa cgggggagcg ctccttttgg cttccttccg     4440

tcga                                                                  4444


