                         SEQUENCE LISTING

<110>  Evonik Industries AG
 
<120>  METHIONINE PRODUCTION

<130>  201500052

<150>  15168106.1
<151>  2015-05-19

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  1049
<212>  PRT
<213>  Bacillus megaterium

<400>  1

Met Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys 
1               5                   10                  15      


Asn Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys 
            20                  25                  30          


Ile Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Arg 
        35                  40                  45              


Val Thr Arg Tyr Leu Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp 
    50                  55                  60                  


Glu Ser Arg Phe Asp Lys Asn Leu Ser Gln Ala Leu Lys Phe Val Arg 
65                  70                  75                  80  


Asp Phe Ala Gly Asp Gly Leu Phe Thr Ser Trp Thr His Glu Lys Asn 
                85                  90                  95      


Trp Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala 
            100                 105                 110         


Met Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val 
        115                 120                 125             


Gln Lys Trp Glu Arg Leu Asn Ala Asp Glu His Ile Glu Val Pro Glu 
    130                 135                 140                 


Asp Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn 
145                 150                 155                 160 


Tyr Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Thr 
                165                 170                 175     


Ser Met Val Arg Ala Leu Asp Glu Ala Met Asn Lys Leu Gln Arg Ala 
            180                 185                 190         


Asn Pro Asp Asp Pro Ala Tyr Asp Glu Asn Lys Arg Gln Phe Gln Glu 
        195                 200                 205             


Asp Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg 
    210                 215                 220                 


Lys Ala Ser Gly Glu Gln Ser Asp Asp Leu Leu Thr His Met Leu Asn 
225                 230                 235                 240 


Gly Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Glu Asn Ile Arg 
                245                 250                 255     


Tyr Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly 
            260                 265                 270         


Leu Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro His Val Leu 
        275                 280                 285             


Gln Lys Ala Ala Glu Glu Ala Ala Arg Val Leu Val Asp Pro Val Pro 
    290                 295                 300                 


Ser Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn 
305                 310                 315                 320 


Glu Ala Leu Arg Leu Trp Pro Thr Ala Pro Ala Phe Ser Leu Tyr Ala 
                325                 330                 335     


Lys Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp 
            340                 345                 350         


Glu Leu Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Ile Trp 
        355                 360                 365             


Gly Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser 
    370                 375                 380                 


Ala Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala 
385                 390                 395                 400 


Cys Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly 
                405                 410                 415     


Met Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu 
            420                 425                 430         


Asp Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Gly Phe Val Val Lys 
        435                 440                 445             


Ala Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr 
    450                 455                 460                 


Glu Gln Ser Ala Lys Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn 
465                 470                 475                 480 


Thr Pro Leu Leu Val Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly 
                485                 490                 495     


Thr Ala Arg Asp Leu Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro 
            500                 505                 510         


Gln Val Ala Thr Leu Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly 
        515                 520                 525             


Ala Val Leu Ile Val Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn 
    530                 535                 540                 


Ala Lys Gln Phe Val Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val 
545                 550                 555                 560 


Lys Gly Val Arg Tyr Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala 
                565                 570                 575     


Thr Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp Glu Thr Leu Ala Ala 
            580                 585                 590         


Lys Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp 
        595                 600                 605             


Asp Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp 
    610                 615                 620                 


Val Ala Ala Tyr Phe Asn Leu Asp Ile Glu Asn Ser Glu Asp Asn Lys 
625                 630                 635                 640 


Ser Thr Leu Ser Leu Gln Phe Val Asp Ser Ala Ala Asp Met Pro Leu 
                645                 650                 655     


Ala Lys Met His Gly Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu 
            660                 665                 670         


Leu Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu 
        675                 680                 685             


Leu Pro Lys Glu Ala Ser Tyr Gln Glu Gly Asp His Leu Gly Val Ile 
    690                 695                 700                 


Pro Arg Asn Tyr Glu Gly Ile Val Asn Arg Val Thr Ala Arg Phe Gly 
705                 710                 715                 720 


Leu Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu 
                725                 730                 735     


Ala His Leu Pro Leu Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln 
            740                 745                 750         


Tyr Val Glu Leu Gln Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met 
        755                 760                 765             


Ala Ala Lys Thr Val Cys Pro Pro His Lys Val Glu Leu Glu Ala Leu 
    770                 775                 780                 


Leu Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr 
785                 790                 795                 800 


Met Leu Glu Leu Leu Glu Lys Tyr Pro Ala Cys Glu Met Lys Phe Ser 
                805                 810                 815     


Glu Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile 
            820                 825                 830         


Ser Ser Ser Pro Arg Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser 
        835                 840                 845             


Val Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile 
    850                 855                 860                 


Ala Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys 
865                 870                 875                 880 


Phe Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu 
                885                 890                 895     


Thr Pro Leu Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg 
            900                 905                 910         


Gly Phe Val Gln Ala Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu 
        915                 920                 925             


Gly Glu Ala His Leu Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr 
    930                 935                 940                 


Leu Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr 
945                 950                 955                 960 


Leu His Thr Ala Phe Ser Arg Met Pro Asn Gln Pro Lys Thr Tyr Val 
                965                 970                 975     


Gln His Val Met Glu Gln Asp Gly Lys Lys Leu Ile Glu Leu Leu Asp 
            980                 985                 990         


Gln Gly Ala His Phe Tyr Ile Cys  Gly Asp Gly Ser Gln  Met Ala Pro 
        995                 1000                 1005             


Ala Val  Glu Ala Thr Leu Met  Lys Ser Tyr Ala Asp  Val His Gln 
    1010                 1015                 1020             


Val Ser  Glu Ala Asp Ala Arg  Leu Trp Leu Gln Gln  Leu Glu Glu 
    1025                 1030                 1035             


Lys Gly  Arg Tyr Ala Lys Asp  Val Trp Ala Gly 
    1040                 1045                 


<210>  2
<211>  3147
<212>  DNA
<213>  Bacillus megaterium

<400>  2
atgacaatta aagaaatgcc tcagccaaaa acgtttggag agcttaaaaa tttaccgtta       60

ttaaacacag ataaaccggt tcaagctttg atgaaaattg cggatgaatt aggagaaatc      120

tttaaattcg aggcgcctgg tcgtgtaacg cgctacttat caagtcagcg tctaattaaa      180

gaagcatgcg atgaatcacg ctttgataaa aacttaagtc aagcgcttaa atttgtacgt      240

gattttgcag gagacgggtt atttacaagc tggacgcatg aaaaaaattg gaaaaaagcg      300

cataatatct tacttccaag cttcagtcag caggcaatga aaggctatca tgcgatgatg      360

gtcgatatcg ccgtgcagct tgttcaaaag tgggagcgtc taaatgcaga tgagcatatt      420

gaagtaccgg aagacatgac acgtttaacg cttgatacaa ttggtctttg cggctttaac      480

tatcgcttta acagctttta ccgagatcag cctcatccat ttattacaag tatggtccgt      540

gcactggatg aagcaatgaa caagctgcag cgagcaaatc cagacgaccc agcttatgat      600

gaaaacaagc gccagtttca agaagatatc aaggtgatga acgacctagt agataaaatt      660

attgcagatc gcaaagcaag cggtgaacaa agcgatgatt tattaacgca tatgctaaac      720

ggaaaagatc cagaaacggg tgagccgctt gatgacgaga acattcgcta tcaaattatt      780

acattcttaa ttgcgggaca cgaaacaaca agtggtcttt tatcatttgc gctgtatttc      840

ttagtgaaaa atccacatgt attacaaaaa gcagcagaag aagcagcacg agttctagta      900

gatcctgttc caagctacaa acaagtcaaa cagcttaaat atgtcggcat ggtcttaaac      960

gaagcgctgc gcttatggcc aactgctcct gcgttttccc tatatgcaaa agaagatacg     1020

gtgcttggag gagaatatcc tttagaaaaa ggcgacgaac taatggttct gattcctcag     1080

cttcaccgtg ataaaacaat ttggggagac gatgtggaag agttccgtcc agagcgtttt     1140

gaaaatccaa gtgcgattcc gcagcatgcg tttaaaccgt ttggaaacgg tcagcgtgcg     1200

tgtatcggtc agcagttcgc tcttcatgaa gcaacgctgg tacttggtat gatgctaaaa     1260

cactttgact ttgaagatca tacaaactac gagctggata ttaaagaaac tttaacgtta     1320

aaacctgaag gctttgtggt aaaagcaaaa tcgaaaaaaa ttccgcttgg cggtattcct     1380

tcacctagca ctgaacagtc tgctaaaaaa gtacgcaaaa aggcagaaaa cgctcataat     1440

acgccgctgc ttgtgctata cggttcaaat atgggaacag ctgaaggaac ggcgcgtgat     1500

ttagcagata ttgcaatgag caaaggattt gcaccgcagg tcgcaacgct tgattcacac     1560

gccggaaatc ttccgcgcga aggagctgta ttaattgtaa cggcgtctta taacggtcat     1620

ccgcctgata acgcaaagca atttgtcgac tggttagacc aagcgtctgc tgatgaagta     1680

aaaggcgttc gctactccgt atttggatgc ggcgataaaa actgggctac tacgtatcaa     1740

aaagtgcctg cttttatcga tgaaacgctt gccgctaaag gggcagaaaa catcgctgac     1800

cgcggtgaag cagatgcaag cgacgacttt gaaggcacat atgaagaatg gcgtgaacat     1860

atgtggagtg acgtagcagc ctactttaac ctcgacattg aaaacagtga agataataaa     1920

tctactcttt cacttcaatt tgtcgacagc gccgcggata tgccgcttgc gaaaatgcac     1980

ggtgcgtttt caacgaacgt cgtagcaagc aaagaacttc aacagccagg cagtgcacga     2040

agcacgcgac atcttgaaat tgaacttcca aaagaagctt cttatcaaga aggagatcat     2100

ttaggtgtta ttcctcgcaa ctatgaagga atagtaaacc gtgtaacagc aaggttcggc     2160

ctagatgcat cacagcaaat ccgtctggaa gcagaagaag aaaaattagc tcatttgcca     2220

ctcgctaaaa cagtatccgt agaagagctt ctgcaatacg tggagcttca agatcctgtt     2280

acgcgcacgc agcttcgcgc aatggctgct aaaacggtct gcccgccgca taaagtagag     2340

cttgaagcct tgcttgaaaa gcaagcctac aaagaacaag tgctggcaaa acgtttaaca     2400

atgcttgaac tgcttgaaaa atacccggcg tgtgaaatga aattcagcga atttatcgcc     2460

cttctgccaa gcatacgccc gcgctattac tcgatttctt catcacctcg tgtcgatgaa     2520

aaacaagcaa gcatcacggt cagcgttgtc tcaggagaag cgtggagcgg atatggagaa     2580

tataaaggaa ttgcgtcgaa ctatcttgcc gagctgcaag aaggagatac gattacgtgc     2640

tttatttcca caccgcagtc agaatttacg ctgccaaaag accctgaaac gccgcttatc     2700

atggtcggac cgggaacagg cgtcgcgccg tttagaggct ttgtgcaggc gcgcaaacag     2760

ctaaaagaac aaggacagtc acttggagaa gcacatttat acttcggctg ccgttcacct     2820

catgaagact atctgtatca agaagagctt gaaaacgccc aaagcgaagg catcattacg     2880

cttcataccg ctttttctcg catgccaaat cagccgaaaa catacgttca gcacgtaatg     2940

gaacaagacg gcaagaaatt gattgaactt cttgatcaag gagcgcactt ctatatttgc     3000

ggagacggaa gccaaatggc acctgccgtt gaagcaacgc ttatgaaaag ctatgctgac     3060

gttcaccaag tgagtgaagc agacgctcgc ttatggctgc agcagctaga agaaaaaggc     3120

cgatacgcaa aagacgtgtg ggctggg                                         3147


<210>  3
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-HIC-DH

<400>  3

Met Ala Arg Lys Ile Gly Ile Ile Gly Leu Gly Asn Val Gly Ala Ala 
1               5                   10                  15      


Val Ala His Gly Leu Ile Ala Gln Gly Val Ala Asp Asp Tyr Val Phe 
            20                  25                  30          


Ile Asp Ala Asn Glu Ala Lys Val Lys Ala Asp Gln Ile Asp Phe Gln 
        35                  40                  45              


Asp Ala Met Ala Asn Leu Glu Ala His Gly Asn Ile Val Ile Asn Asp 
    50                  55                  60                  


Trp Ala Ala Leu Ala Asp Ala Asp Val Val Ile Ser Thr Leu Gly Asn 
65                  70                  75                  80  


Ile Lys Leu Gln Gln Asp Asn Pro Thr Gly Asp Arg Phe Ala Glu Leu 
                85                  90                  95      


Lys Phe Thr Ser Ser Met Val Gln Ser Val Gly Thr Asn Leu Lys Glu 
            100                 105                 110         


Ser Gly Phe His Gly Val Leu Val Val Ile Ser Asn Pro Val Asp Val 
        115                 120                 125             


Ile Thr Ala Leu Phe Gln His Val Thr Gly Phe Pro Ala His Lys Val 
    130                 135                 140                 


Ile Gly Thr Gly Thr Leu Leu Asp Thr Ala Arg Met Gln Arg Ala Val 
145                 150                 155                 160 


Gly Glu Ala Phe Asp Leu Asp Pro Arg Ser Val Ser Gly Tyr Asn Leu 
                165                 170                 175     


Gly Glu His Gly Asn Ser Gln Phe Val Ala Trp Ser Thr Val Arg Val 
            180                 185                 190         


Met Gly Gln Pro Ile Val Thr Leu Ala Asp Ala Gly Asp Ile Asp Leu 
        195                 200                 205             


Ala Ala Ile Glu Glu Glu Ala Arg Lys Gly Gly Phe Thr Val Leu Asn 
    210                 215                 220                 


Gly Lys Gly Tyr Thr Ser Tyr Gly Val Ala Thr Ser Ala Ile Arg Ile 
225                 230                 235                 240 


Ala Lys Ala Val Met Ala Asp Ala His Ala Glu Leu Val Val Ser Asn 
                245                 250                 255     


Arg Arg Asp Asp Met Gly Met Tyr Leu Ser Tyr Pro Ala Ile Ile Gly 
            260                 265                 270         


Arg Asp Gly Val Leu Ala Glu Thr Thr Leu Asp Leu Thr Thr Asp Glu 
        275                 280                 285             


Gln Glu Lys Leu Leu Gln Ser Arg Asp Tyr Ile Gln Gln Arg Phe Asp 
    290                 295                 300                 


Glu Ile Val Asp Thr Leu 
305                 310 


<210>  4
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leucine-DH

<400>  4

Met Glu Leu Phe Lys Tyr Met Glu Thr Tyr Asp Tyr Glu Gln Val Leu 
1               5                   10                  15      


Phe Cys Gln Asp Lys Glu Ser Gly Leu Lys Ala Ile Ile Ala Ile His 
            20                  25                  30          


Asp Thr Thr Leu Gly Pro Ala Leu Gly Gly Thr Arg Met Trp Met Tyr 
        35                  40                  45              


Asn Ser Glu Glu Glu Ala Leu Glu Asp Ala Leu Arg Leu Ala Arg Gly 
    50                  55                  60                  


Met Thr Tyr Ser Asn Ala Ala Ala Gly Leu Asn Leu Gly Gly Gly Lys 
65                  70                  75                  80  


Thr Val Ile Ile Gly Asp Pro Arg Lys Asp Lys Asn Glu Ala Met Phe 
                85                  90                  95      


Arg Ala Phe Gly Arg Phe Ile Gln Gly Leu Asn Gly Arg Tyr Ile Thr 
            100                 105                 110         


Ala Val Asp Val Gly Thr Thr Val Ala Asp Met Asp Ile Ile Tyr Gln 
        115                 120                 125             


Glu Thr Asp Tyr Val Thr Gly Ile Ser Pro Glu Phe Gly Ser Ser Gly 
    130                 135                 140                 


Asn Pro Ser Pro Ala Thr Ala Tyr Gly Val Tyr Arg Gly Met Lys Ala 
145                 150                 155                 160 


Ala Ala Lys Glu Ala Phe Gly Ser Asp Ser Leu Glu Gly Lys Val Val 
                165                 170                 175     


Ala Val Gln Gly Val Gly Asn Val Ala Tyr His Leu Cys Arg His Leu 
            180                 185                 190         


His Glu Glu Gly Ala Lys Leu Ile Val Thr Asp Ile Asn Lys Glu Val 
        195                 200                 205             


Val Ala Arg Ala Val Glu Glu Phe Gly Ala Lys Ala Val Asp Pro Asn 
    210                 215                 220                 


Asp Ile Tyr Gly Val Glu Cys Asp Ile Phe Ala Pro Cys Ala Leu Gly 
225                 230                 235                 240 


Gly Ile Ile Asn Asp Gln Thr Ile Pro Gln Leu Lys Ala Lys Val Ile 
                245                 250                 255     


Ala Gly Ser Ala Asp Leu Gln Leu Lys Glu Pro Arg His Gly Asp Ile 
            260                 265                 270         


Ile His Glu Met Gly Ile Val Tyr Ala Pro Asp Tyr Val Ile Asn Ala 
        275                 280                 285             


Gly Gly Cys Ile Asn Val Ala Asp Glu Leu Tyr Gly Tyr Asn Arg Glu 
    290                 295                 300                 


Arg Ala Met Lys Lys Ile Glu Gln Ile Tyr Asp Asn Ile Glu Lys Val 
305                 310                 315                 320 


Phe Ala Ile Ala Lys Arg Asp Asn Ile Pro Thr Tyr Val Ala Ala Asp 
                325                 330                 335     


Arg Met Ala Glu Glu Arg Ile Glu Thr Met Arg Lys Ala Ala Ser Gln 
            340                 345                 350         


Phe Leu Gln Asn Gly His His Ile Leu Ser Arg Arg Pro Arg Pro Leu 
        355                 360                 365             


Thr Ala Ala Arg Ala Gly Leu Arg Arg Ala Asp Asp Gly Gly Thr Thr 
    370                 375                 380                 


Thr Met Gln Glu Gln Lys Phe Arg Ile Leu Thr Ile Asn Pro Gly Ser 
385                 390                 395                 400 


Thr Ser Thr Lys Ile Gly Val Phe Glu Asn Glu Arg Ala Ile Ala Ser 
                405                 410                 415     


Lys Lys Arg Ser Ala Thr Arg Ala Gly Ala Ser Ala Ile 
            420                 425                 


<210>  5
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D-HIC-DH

<400>  5

Met Lys Ile Ile Ala Tyr Gly Ala Arg Val Asp Glu Ile Gln Tyr Phe 
1               5                   10                  15      


Lys Gln Trp Ala Lys Asp Thr Gly Asn Thr Leu Glu Tyr His Thr Glu 
            20                  25                  30          


Phe Leu Asp Glu Asn Thr Val Glu Trp Ala Lys Gly Phe Asp Gly Ile 
        35                  40                  45              


Asn Ser Leu Gln Thr Thr Pro Tyr Ala Ala Gly Val Phe Glu Lys Met 
    50                  55                  60                  


His Ala Tyr Gly Ile Lys Phe Leu Thr Ile Arg Asn Val Gly Thr Asp 
65                  70                  75                  80  


Asn Ile Asp Met Thr Ala Met Lys Gln Tyr Gly Ile Arg Leu Ser Asn 
                85                  90                  95      


Val Pro Ala Tyr Ser Pro Ala Ala Ile Ala Glu Phe Ala Leu Thr Asp 
            100                 105                 110         


Thr Leu Tyr Leu Leu Arg Asn Met Gly Lys Val Gln Ala Gln Leu Gln 
        115                 120                 125             


Ala Gly Asp Tyr Glu Lys Ala Gly Thr Phe Ile Gly Lys Glu Leu Gly 
    130                 135                 140                 


Gln Gln Thr Val Gly Val Met Gly Thr Gly His Ile Gly Gln Val Ala 
145                 150                 155                 160 


Ile Lys Leu Phe Lys Gly Phe Gly Ala Lys Val Ile Ala Tyr Asp Pro 
                165                 170                 175     


Tyr Pro Met Lys Gly Asp His Pro Asp Phe Asp Tyr Val Ser Leu Glu 
            180                 185                 190         


Asp Leu Phe Lys Gln Ser Asp Val Ile Asp Leu His Val Pro Gly Ile 
        195                 200                 205             


Glu Gln Asn Thr His Ile Ile Asn Glu Ala Ala Phe Asn Leu Met Lys 
    210                 215                 220                 


Pro Gly Ala Ile Val Ile Asn Thr Ala Arg Pro Asn Leu Ile Asp Thr 
225                 230                 235                 240 


Gln Ala Met Leu Ser Asn Leu Lys Ser Gly Lys Leu Ala Gly Val Gly 
                245                 250                 255     


Ile Asp Thr Tyr Glu Tyr Glu Thr Glu Asp Leu Leu Asn Leu Ala Lys 
            260                 265                 270         


His Gly Ser Phe Lys Asp Pro Leu Trp Asp Glu Leu Leu Gly Met Pro 
        275                 280                 285             


Asn Val Val Leu Ser Pro His Ile Ala Tyr Tyr Thr Glu Thr Ala Val 
    290                 295                 300                 


His Asn Met Val Tyr Phe Ser Leu Gln His Leu Val Asp Phe Leu Thr 
305                 310                 315                 320 


Lys Gly Glu Thr Ser Thr Glu Val Thr Gly Pro Ala Lys 
                325                 330             


<210>  6
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer: R47/Y51 Fw


<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  n is a, c, g, or t

<400>  6
cgaggcgcct ggtnnkgtaa cgcgcnnktt atcaagtcag cg                          42


<210>  7
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer: R47/Y51 Rv


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  n is a, c, g, or t

<400>  7
cgctgacttg ataamnngcg cgttacmnna ccaggcgcct cg                          42


<210>  8
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer: I401 Fw


<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  n is a, c, g, or t

<400>  8
cagcgtgcgt gtnnkggtca gcagttc                                           27


<210>  9
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer: I401 Rw


<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  n is a, c, g, or t

<400>  9
gaactgctga ccmnnacacg cacgctg                                           27


