                         SEQUENCE LISTING

<110>  The Board of Regents of the University of Oklahoma
 
<120>  VARIANTS OF ADRENOMEDULLIN AND CALCITONIN GENE-RELATED PEPTIDE 
       AND METHODS OF USE

<130>  5835.162wo

<150>  62/160,899
<151>  2015-05-13

<160>  54    

<170>  PatentIn version 3.5

<210>  1
<211>  52
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DISULFID
<222>  (16)..(21)

<220>
<221>  MOD_RES
<222>  (52)..(52)
<223>  AMIDATION

<400>  1

Tyr Arg Gln Ser Met Asn Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys 
1               5                   10                  15      


Arg Phe Gly Thr Cys Thr Val Gln Lys Leu Ala His Gln Ile Tyr Gln 
            20                  25                  30          


Phe Thr Asp Lys Asp Lys Asp Asn Val Ala Pro Arg Ser Lys Ile Ser 
        35                  40                  45              


Pro Gln Gly Tyr 
    50          


<210>  2
<211>  40
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DISULFID
<222>  (4)..(9)

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  AMIDATION

<400>  2

Ser Phe Gly Cys Arg Phe Gly Thr Cys Thr Val Gln Lys Leu Ala His 
1               5                   10                  15      


Gln Ile Tyr Gln Phe Thr Asp Lys Asp Lys Asp Asn Val Ala Pro Arg 
            20                  25                  30          


Ser Lys Ile Ser Pro Gln Gly Tyr 
        35                  40  


<210>  3
<211>  31
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  AMIDATION

<400>  3

Thr Val Gln Lys Leu Ala His Gln Ile Tyr Gln Phe Thr Asp Lys Asp 
1               5                   10                  15      


Lys Asp Asn Val Ala Pro Arg Ser Lys Ile Ser Pro Gln Gly Tyr 
            20                  25                  30      


<210>  4
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  4

Asp Lys Asp Asn Val Ala Pro Arg Ser Lys Ile Ser Pro Gln Gly Tyr 
1               5                   10                  15      


<210>  5
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant of SEQ ID NO:4


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  5

Asp Lys Asp Asn Val Ala Pro Arg Ser Lys Ile Ser Pro Phe Gly Tyr 
1               5                   10                  15      


<210>  6
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:4


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  6

Asp Lys Asp Asn Val Ala Pro Arg Ser Lys Ile Ser Pro Trp Gly Tyr 
1               5                   10                  15      


<210>  7
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:4


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  7

Asp Lys Asp Asn Val Ala Pro Arg Ser Leu Ile Ser Pro Gln Gly Tyr 
1               5                   10                  15      


<210>  8
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:4


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  8

Asp Lys Asp Asn Val Ala Pro Arg Ser Met Ile Ser Pro Gln Gly Tyr 
1               5                   10                  15      


<210>  9
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:4


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  9

Asp Lys Asp Asn Val Ala Pro Arg Ser Trp Ile Ser Pro Gln Gly Tyr 
1               5                   10                  15      


<210>  10
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:4


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  10

Asp Lys Lys Asn Val Ala Pro Arg Ser Lys Ile Ser Pro Gln Gly Tyr 
1               5                   10                  15      


<210>  11
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:4


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  11

Asp Lys Asp Asn Val Ala Pro Arg Trp Lys Ile Ser Pro Trp Gly Tyr 
1               5                   10                  15      


<210>  12
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:4


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  12

Asp Lys Asp Asn Val Ala Pro Arg Ser Leu Ile Ser Pro Trp Gly Tyr 
1               5                   10                  15      


<210>  13
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:4


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  13

Asp Lys Trp Asn Val Ala Pro Arg Ser Lys Ile Ser Pro Trp Gly Tyr 
1               5                   10                  15      


<210>  14
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:4


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  14

Asp Lys Lys Asn Val Ala Pro Arg Ser Lys Ile Ser Pro Phe Gly Tyr 
1               5                   10                  15      


<210>  15
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:4


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  15

Asp Lys Lys Asn Val Ala Pro Arg Ser Lys Ile Ser Pro Trp Gly Tyr 
1               5                   10                  15      


<210>  16
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:4


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  16

Asp Lys Asp Asn Val Ala Pro Arg Ser Leu Ile Ser Pro Trp Gly Phe 
1               5                   10                  15      


<210>  17
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:4


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  17

Asp Lys Phe Asn Val Ala Pro Arg Ser Leu Ile Ser Pro Trp Gly Tyr 
1               5                   10                  15      


<210>  18
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:4


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  18

Asp Lys Asp Asn Val Ala Pro Arg Arg Trp Ile Ser Pro Trp Gly Tyr 
1               5                   10                  15      


<210>  19
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:4


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  19

Asp Lys Asp Asn Val Ala Pro Arg Arg Leu Ile Ser Pro Trp Gly Tyr 
1               5                   10                  15      


<210>  20
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:4


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  20

Asp Lys Phe Asn Val Ala Pro Arg Ser Leu Ile Ser Pro Trp Gly Phe 
1               5                   10                  15      


<210>  21
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:4


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  21

Asp Lys Asp Asn Val Ala Pro Arg Trp Trp Ile Ser Pro Trp Gly Phe 
1               5                   10                  15      


<210>  22
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:4


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  22

Asp Lys Asp Asn Val Ala Pro Arg Trp Leu Ile Ser Pro Trp Gly Phe 
1               5                   10                  15      


<210>  23
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:4


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  23

Asp Lys Asp Asn Val Ala Pro Arg Trp Met Ile Ser Pro Trp Gly Phe 
1               5                   10                  15      


<210>  24
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:4


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  24

Asp Lys Asp Asn Val Ala Pro Arg Arg Trp Ile Gly Pro Trp Gly Tyr 
1               5                   10                  15      


<210>  25
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:4


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  25

Asp Lys Asp Asn Val Ala Pro Arg Arg Leu Ile Gly Pro Trp Gly Tyr 
1               5                   10                  15      


<210>  26
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:4


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  26

Val Lys Asp Asn Val Ala Pro Arg Trp Leu Ile Ser Pro Trp Gly Phe 
1               5                   10                  15      


<210>  27
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:4


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  27

Asp Lys Asp Asn Val Ala Pro Arg Trp Leu Ile Gly Pro Trp Gly Phe 
1               5                   10                  15      


<210>  28
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:4


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  28

Asp Lys Asp Asn Val Ala Pro Arg Trp Leu Met Ser Pro Trp Gly Phe 
1               5                   10                  15      


<210>  29
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:4


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  29

Asp Lys Asp Asn Val Ala Pro Arg Arg Trp Leu Gly Pro Trp Gly Tyr 
1               5                   10                  15      


<210>  30
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:4


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  30

Asp Lys Lys Asn Val Ala Pro Arg Arg Leu Ile Gly Pro Trp Gly Tyr 
1               5                   10                  15      


<210>  31
<211>  37
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DISULFID
<222>  (2)..(7)

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  AMIDATION

<400>  31

Ala Cys Asp Thr Ala Thr Cys Val Thr His Arg Leu Ala Gly Leu Leu 
1               5                   10                  15      


Ser Arg Ser Gly Gly Val Val Lys Asn Asn Phe Val Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Lys Ala Phe 
        35          


<210>  32
<211>  37
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DISULFID
<222>  (2)..(7)

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  AMIDATION

<400>  32

Ala Cys Asn Thr Ala Thr Cys Val Thr His Arg Leu Ala Gly Leu Leu 
1               5                   10                  15      


Ser Arg Ser Gly Gly Met Val Lys Ser Asn Phe Val Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Lys Ala Phe 
        35          


<210>  33
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  33

Val Thr His Arg Leu Ala Gly Leu Leu Ser Arg Ser Gly Gly Val Val 
1               5                   10                  15      


Lys Asn Asn Phe Val Pro Thr Asn Val Gly Ser Lys Ala Phe 
            20                  25                  30  


<210>  34
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  AMIDATION

<400>  34

Phe Val Pro Thr Asn Val Gly Ser Lys Ala Phe 
1               5                   10      


<210>  35
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  AMIDATION

<400>  35

Phe Val Pro Thr Asp Val Gly Pro Phe Ala Phe 
1               5                   10      


<210>  36
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:34


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  AMIDATION

<400>  36

Phe Val Pro Thr Asp Val Gly Pro Trp Ala Phe 
1               5                   10      


<210>  37
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:34


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  AMIDATION

<400>  37

Phe Val Pro Thr Asp Val Gly Pro Trp Ala Tyr 
1               5                   10      


<210>  38
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:34


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  AMIDATION

<400>  38

Phe Val Pro Thr Asp Val Gly Pro Phe Ser Phe 
1               5                   10      


<210>  39
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:34


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  AMIDATION

<400>  39

Phe Val Pro Thr Asp Val Gly Pro Trp Ser Phe 
1               5                   10      


<210>  40
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:34


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  AMIDATION

<400>  40

Phe Val Pro Thr Asp Val Gly Pro Trp Ser Tyr 
1               5                   10      


<210>  41
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:34


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  AMIDATION

<400>  41

Phe Val Pro Thr Asp Thr Gly Pro Trp Gly Phe 
1               5                   10      


<210>  42
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:34


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  AMIDATION

<400>  42

Phe Val Pro Thr Asp Thr Gly Pro Trp Ser Phe 
1               5                   10      


<210>  43
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of SEQ ID NO:34


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  AMIDATION

<400>  43

Phe Val Pro Thr Asp Thr Gly Pro Trp Gly Tyr 
1               5                   10      


<210>  44
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of amino acids 30-37 of SEQ ID NO:31


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  44

Thr Asp Val Gly Pro Trp Ala Phe 
1               5               


<210>  45
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of amino acids 30-37 of SEQ ID NO:31


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  45

Thr Asp Val Gly Pro Trp Ser Phe 
1               5               


<210>  46
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant of amino acids 30-37 of SEQ ID NO:31


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  46

Thr Asp Val Gly Pro Trp Ser Tyr 
1               5               


<210>  47
<211>  40
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DISULFID
<222>  (3)..(8)

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  AMIDATION

<400>  47

Val Gly Cys Val Leu Gly Thr Cys Gln Val Gln Asn Leu Ser His Arg 
1               5                   10                  15      


Leu Trp Gln Leu Met Gly Pro Ala Gly Arg Gln Asp Ser Ala Pro Val 
            20                  25                  30          


Asp Pro Ser Ser Pro His Ser Tyr 
        35                  40  


<210>  48
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  48

Val Gly Cys Val Leu Gly Thr Cys Gln Val Gln Asn Leu Ser His Arg 
1               5                   10                  15      


Leu Trp Gln Leu Met Gly Pro Ala 
            20                  


<210>  49
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variants based on amino acids 37-52 of SEQ ID NO:1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is A, D, V, L or I

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is D, F, M, Y, V, I, E, K, W, L, or R

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is S, W, Y, F, R, T, or L

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X is K, G, L, M, Y, A, W, or F

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is I, L, or M

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X is S, T, or G

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X is Q, F, Y, W, or H

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X is Y or F.

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  49

Xaa Lys Xaa Asn Val Ala Pro Arg Xaa Xaa Xaa Xaa Pro Xaa Gly Xaa 
1               5                   10                  15      


<210>  50
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variants based on amino acids 42-52 of SEQ ID NO:1


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is S, W, Y, F, R, T, or L

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is K, G, L, M, Y, A, W, or F

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is I, L, or M

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is S, T, or G

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is Q, F, Y, W, or H

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is Y or F

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  AMIDATION

<400>  50

Ala Pro Arg Xaa Xaa Xaa Xaa Pro Xaa Gly Xaa 
1               5                   10      


<210>  51
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variants based on amino acids 27-37 of SEQ ID NO:31


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is N, D, or W

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is V, T, or W

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is P or S

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is W, Y, or H

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X is A, S, or G

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is Y or F

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  AMIDATION

<400>  51

Phe Val Pro Thr Xaa Xaa Gly Xaa Xaa Xaa Xaa 
1               5                   10      


<210>  52
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variants based on amino acids 30-37 of SEQ ID NO:31


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is N, D, or W

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is V, T, or W

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is P or S

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is W, Y, or H

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is A, S, or G

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is F or Y

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  52

Thr Xaa Xaa Gly Xaa Xaa Xaa Xaa 
1               5               


<210>  53
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence used to create variant peptide positional 
       libraries based on amino acids 37-52 of SEQ ID NO:1


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is A, R, N, D, E, Q, G, H, I, L, K, M, F, P, S, T, W, Y, or V

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X is A, R, N, D, E, Q, G, H, I, L, K, M, F, P, S, T, W, Y, or V

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is A, R, N, D, E, Q, G, H, I, L, K, M, F, P, S, T, W, Y, or V

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X is A, R, N, D, E, Q, G, H, I, L, K, M, F, P, S, T, W, Y, or V

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X is A, R, N, D, E, Q, G, H, I, L, K, M, F, P, S, T, W, Y, or V

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  53

Asp Lys Asp Asn Val Ala Pro Arg Xaa Xaa Xaa Xaa Pro Trp Gly Xaa 
1               5                   10                  15      


<210>  54
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence used to create variant peptide positional 
       libraries based on amino acids 27-37 of SEQ ID NO:31


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is A, R, N, D, E, Q, G, H, I, L, K, M, F, P, S, T, W, Y, or V

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is A, R, N, D, E, Q, G, H, I, L, K, M, F, P, S, T, W, Y, or V

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is A, R, N, D, E, Q, G, H, I, L, K, M, F, P, S, T, W, Y, or V

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X is A, R, N, D, E, Q, G, H, I, L, K, M, F, P, S, T, W, Y, or V

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is A, R, N, D, E, Q, G, H, I, L, K, M, F, P, S, T, W, Y, or V

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  AMIDATION

<400>  54

Phe Val Pro Thr Xaa Xaa Xaa Pro Trp Xaa Xaa 
1               5                   10      


