                         SEQUENCE LISTING

<110>  Syntimmune, Inc
 
<120>  Humanized Affinity-Matured Anti-FcRn Antibodies

<130>  16196/461P1

<160>  78    

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(15)

<400>  1
agc tat ggt ata agc                                                     15
Ser Tyr Gly Ile Ser                                                       
1               5                                                         


<210>  2
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  2

Ser Tyr Gly Ile Ser 
1               5   


<210>  3
<211>  51
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(51)

<400>  3
gag att tat cct aga agt ggt aat act tac tac aat gag aag ttc aag         48
Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe Lys           
1               5                   10                  15                

ggc                                                                     51
Gly                                                                       
                                                                          


<210>  4
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  4

Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  33
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(33)

<400>  5
aag gca agt gac cac att aat aat tgg tta gcc                             33
Lys Ala Ser Asp His Ile Asn Asn Trp Leu Ala                               
1               5                   10                                    


<210>  6
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  6

Lys Ala Ser Asp His Ile Asn Asn Trp Leu Ala 
1               5                   10      


<210>  7
<211>  21
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(21)

<400>  7
ggt gca acc agt ttg gaa act                                             21
Gly Ala Thr Ser Leu Glu Thr                                               
1               5                                                         


<210>  8
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  8

Gly Ala Thr Ser Leu Glu Thr 
1               5           


<210>  9
<211>  27
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(27)

<400>  9
caa cag tat tgg agt act ccg tac acg                                     27
Gln Gln Tyr Trp Ser Thr Pro Tyr Thr                                       
1               5                                                         


<210>  10
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  10

Gln Gln Tyr Trp Ser Thr Pro Tyr Thr 
1               5                   


<210>  11
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized


<220>
<221>  CDS
<222>  (1)..(354)

<220>
<221>  misc_feature
<222>  (91)..(105)
<223>  CDR

<220>
<221>  misc_feature
<222>  (148)..(198)
<223>  CDR

<220>
<221>  misc_feature
<222>  (295)..(321)
<223>  CDR

<400>  11
cag gtt cag ctg gtg cag tct gga gct gag ctg aag aag cct ggg gct         48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag ctg tcc tgc aag gct tct ggc tac acc ttc aca nnn nnn         96
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Xaa Xaa           
            20                  25                  30                    

nnn nnn nnn tgg gtg aag cag gcc act gga cag ggc ctt gag tgg att        144
Xaa Xaa Xaa Trp Val Lys Gln Ala Thr Gly Gln Gly Leu Glu Trp Ile           
        35                  40                  45                        

gga nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn        192
Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa           
    50                  55                  60                            

nnn nnn aga gcc aca ctg act gca gac aaa tcc acg agc aca gcg tac        240
Xaa Xaa Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctc cgc agc ctg aga tct gag gac tct gcg gtc tat ttc tgt        288
Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Phe Cys           
                85                  90                  95                

gca aga nnn nnn nnn nnn nnn nnn nnn nnn nnn cgg ggc aca ggg acc        336
Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Gly Thr Gly Thr           
            100                 105                 110                   

acg gtc acc gtc tcc tca                                                354
Thr Val Thr Val Ser Ser                                                   
        115                                                               


<210>  12
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  The 'Xaa' at location 31 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  The 'Xaa' at location 32 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  The 'Xaa' at location 33 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  The 'Xaa' at location 34 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  The 'Xaa' at location 35 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  The 'Xaa' at location 50 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  The 'Xaa' at location 51 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  The 'Xaa' at location 52 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  The 'Xaa' at location 53 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  The 'Xaa' at location 54 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  The 'Xaa' at location 55 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  The 'Xaa' at location 56 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  The 'Xaa' at location 57 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  The 'Xaa' at location 58 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  The 'Xaa' at location 59 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  The 'Xaa' at location 60 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  The 'Xaa' at location 61 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  The 'Xaa' at location 62 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  The 'Xaa' at location 63 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  The 'Xaa' at location 64 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (65)..(65)
<223>  The 'Xaa' at location 65 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  The 'Xaa' at location 66 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (99)..(99)
<223>  The 'Xaa' at location 99 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  The 'Xaa' at location 100 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  The 'Xaa' at location 101 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (102)..(102)
<223>  The 'Xaa' at location 102 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  The 'Xaa' at location 103 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  The 'Xaa' at location 104 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  The 'Xaa' at location 105 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  The 'Xaa' at location 106 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (107)..(107)
<223>  The 'Xaa' at location 107 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<223>  Synthetic Construct

<400>  12

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Val Lys Gln Ala Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Gly Thr Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  13
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized


<220>
<221>  CDS
<222>  (1)..(354)

<220>
<221>  misc_feature
<222>  (91)..(105)
<223>  CDR

<220>
<221>  misc_feature
<222>  (148)..(198)
<223>  CDR

<220>
<221>  misc_feature
<222>  (295)..(321)
<223>  CDR

<400>  13
cag gtt cag ctg gtg cag tct gga gct gag gtg aag aag cct ggg gct         48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag ctg tcc tgc aag gct tct ggc tac acc ttc aca nnn nnn         96
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Xaa Xaa           
            20                  25                  30                    

nnn nnn nnn tgg gtg aag cag gcc cct gga cag ggc ctt gag tgg att        144
Xaa Xaa Xaa Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile           
        35                  40                  45                        

gga nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn        192
Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa           
    50                  55                  60                            

nnn nnn aga gcc aca ctg act gca gac aaa tcc acg agc aca gcg tac        240
Xaa Xaa Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctc cgc agc ctg aga tct gag gac act gcg gtc tat ttc tgt        288
Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys           
                85                  90                  95                

gca aga nnn nnn nnn nnn nnn nnn nnn nnn nnn cgg ggc aca ggg acc        336
Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Gly Thr Gly Thr           
            100                 105                 110                   

acg gtc acc gtc tcc tca                                                354
Thr Val Thr Val Ser Ser                                                   
        115                                                               


<210>  14
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  The 'Xaa' at location 31 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  The 'Xaa' at location 32 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  The 'Xaa' at location 33 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  The 'Xaa' at location 34 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  The 'Xaa' at location 35 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  The 'Xaa' at location 50 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  The 'Xaa' at location 51 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  The 'Xaa' at location 52 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  The 'Xaa' at location 53 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  The 'Xaa' at location 54 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  The 'Xaa' at location 55 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  The 'Xaa' at location 56 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  The 'Xaa' at location 57 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  The 'Xaa' at location 58 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  The 'Xaa' at location 59 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  The 'Xaa' at location 60 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  The 'Xaa' at location 61 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  The 'Xaa' at location 62 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  The 'Xaa' at location 63 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  The 'Xaa' at location 64 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (65)..(65)
<223>  The 'Xaa' at location 65 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  The 'Xaa' at location 66 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (99)..(99)
<223>  The 'Xaa' at location 99 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  The 'Xaa' at location 100 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  The 'Xaa' at location 101 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (102)..(102)
<223>  The 'Xaa' at location 102 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  The 'Xaa' at location 103 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  The 'Xaa' at location 104 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  The 'Xaa' at location 105 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  The 'Xaa' at location 106 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (107)..(107)
<223>  The 'Xaa' at location 107 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<223>  Synthetic Construct

<400>  14

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Gly Thr Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  15
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized


<220>
<221>  CDS
<222>  (1)..(354)

<220>
<221>  misc_feature
<222>  (91)..(105)
<223>  CDR

<220>
<221>  misc_feature
<222>  (148)..(198)
<223>  CDR

<220>
<221>  misc_feature
<222>  (295)..(321)
<223>  CDR

<400>  15
cag gtt cag ctg gtg cag tct gga gct gag gtg aag aag cct ggg gct         48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtg tcc tgc aag gct tct ggc tac acc ttc aca nnn nnn         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Xaa Xaa           
            20                  25                  30                    

nnn nnn nnn tgg gtg cga cag gcc cct gga cag ggc ctt gag tgg att        144
Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile           
        35                  40                  45                        

gga nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn        192
Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa           
    50                  55                  60                            

nnn nnn aga gcc aca att act gca gac aaa tcc acg agc aca gcg tac        240
Xaa Xaa Arg Ala Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctc cgc agc ctg aga tct gag gac act gcg gtc tat tac tgt        288
Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gca aga nnn nnn nnn nnn nnn nnn nnn nnn nnn cgg ggc aca ggg acc        336
Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Gly Thr Gly Thr           
            100                 105                 110                   

acg gtc acc gtc tcc tca                                                354
Thr Val Thr Val Ser Ser                                                   
        115                                                               


<210>  16
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  The 'Xaa' at location 31 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  The 'Xaa' at location 32 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  The 'Xaa' at location 33 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  The 'Xaa' at location 34 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  The 'Xaa' at location 35 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  The 'Xaa' at location 50 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  The 'Xaa' at location 51 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  The 'Xaa' at location 52 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  The 'Xaa' at location 53 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  The 'Xaa' at location 54 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  The 'Xaa' at location 55 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  The 'Xaa' at location 56 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  The 'Xaa' at location 57 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  The 'Xaa' at location 58 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  The 'Xaa' at location 59 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  The 'Xaa' at location 60 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  The 'Xaa' at location 61 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  The 'Xaa' at location 62 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  The 'Xaa' at location 63 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  The 'Xaa' at location 64 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (65)..(65)
<223>  The 'Xaa' at location 65 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  The 'Xaa' at location 66 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (99)..(99)
<223>  The 'Xaa' at location 99 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  The 'Xaa' at location 100 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  The 'Xaa' at location 101 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (102)..(102)
<223>  The 'Xaa' at location 102 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  The 'Xaa' at location 103 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  The 'Xaa' at location 104 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  The 'Xaa' at location 105 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  The 'Xaa' at location 106 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (107)..(107)
<223>  The 'Xaa' at location 107 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<223>  Synthetic Construct

<400>  16

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Arg Ala Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Gly Thr Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  17
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized


<220>
<221>  CDS
<222>  (1)..(354)

<220>
<221>  misc_feature
<222>  (91)..(105)
<223>  CDR

<220>
<221>  misc_feature
<222>  (148)..(198)
<223>  CDR

<220>
<221>  misc_feature
<222>  (295)..(321)
<223>  CDR

<400>  17
cag gtt cag ctg gtg cag tct gga gct gag gtg aag aag cct ggg gct         48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtg tcc tgc aag gct tct ggc tac acc ttc aca nnn nnn         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Xaa Xaa           
            20                  25                  30                    

nnn nnn nnn tgg gtg cga cag gcc cct gga cag ggc ctt gag tgg att        144
Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile           
        35                  40                  45                        

gga nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn        192
Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa           
    50                  55                  60                            

nnn nnn aga gtc aca att act gca gac aaa tcc acg agc aca gcg tac        240
Xaa Xaa Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctc cgc agc ctg aga tct gag gac act gcg gtc tat tac tgt        288
Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gca aga nnn nnn nnn nnn nnn nnn nnn nnn nnn cgg ggc aca ggg acc        336
Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Gly Thr Gly Thr           
            100                 105                 110                   

acg gtc acc gtc tcc tca                                                354
Thr Val Thr Val Ser Ser                                                   
        115                                                               


<210>  18
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  The 'Xaa' at location 31 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  The 'Xaa' at location 32 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  The 'Xaa' at location 33 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  The 'Xaa' at location 34 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  The 'Xaa' at location 35 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  The 'Xaa' at location 50 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  The 'Xaa' at location 51 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  The 'Xaa' at location 52 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  The 'Xaa' at location 53 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  The 'Xaa' at location 54 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  The 'Xaa' at location 55 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  The 'Xaa' at location 56 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  The 'Xaa' at location 57 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  The 'Xaa' at location 58 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  The 'Xaa' at location 59 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  The 'Xaa' at location 60 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  The 'Xaa' at location 61 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  The 'Xaa' at location 62 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  The 'Xaa' at location 63 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  The 'Xaa' at location 64 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (65)..(65)
<223>  The 'Xaa' at location 65 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  The 'Xaa' at location 66 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (99)..(99)
<223>  The 'Xaa' at location 99 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  The 'Xaa' at location 100 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  The 'Xaa' at location 101 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (102)..(102)
<223>  The 'Xaa' at location 102 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  The 'Xaa' at location 103 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  The 'Xaa' at location 104 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  The 'Xaa' at location 105 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  The 'Xaa' at location 106 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (107)..(107)
<223>  The 'Xaa' at location 107 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<223>  Synthetic Construct

<400>  18

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Gly Thr Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  19
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized


<220>
<221>  CDS
<222>  (1)..(321)

<400>  19
gac atc cag atg aca caa tct cct tcc tac ttg tct gca tct gta gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Tyr Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc acc att act tgc aag gca agt gac cac att aat aat tgg         96
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp           
            20                  25                  30                    

tta gcc tgg tat cag cag aaa cca gga cag gct cct agg ctc tta ata        144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile           
        35                  40                  45                        

tct ggt gca acc agt ttg gaa act ggg gtt cct tca aga ttc agt ggc        192
Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt gga act gga aag gat tac act ctc acc att agc agt ctt cag act        240
Ser Gly Thr Gly Lys Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Thr           
65                  70                  75                  80            

gaa gat ttt gct acg tat tac tgt caa cag tat tgg agt act ccg tac        288
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Tyr           
                85                  90                  95                

acg ttc gga ggg ggg acc aag gtg gaa ata aaa                            321
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys                               
            100                 105                                       


<210>  20
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ser Tyr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Thr Gly Lys Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  21
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized


<220>
<221>  CDS
<222>  (1)..(321)

<400>  21
gac atc cag atg aca caa tct cct tcc tcc ttg tct gca tct gta gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc acc att act tgc aag gca agt gac cac att aat aat tgg         96
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp           
            20                  25                  30                    

tta gcc tgg tat cag cag aaa cca gga cag gct cct agg ctc tta ata        144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile           
        35                  40                  45                        

tct ggt gca acc agt ttg gaa act ggg gtt cct tca aga ttc agt ggc        192
Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt gga act gga aag gat tac act ctc acc att agc agt ctt cag cct        240
Ser Gly Thr Gly Lys Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro           
65                  70                  75                  80            

gaa gat ttt gct acg tat tac tgt caa cag tat tgg agt act ccg tac        288
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Tyr           
                85                  90                  95                

acg ttc gga ggg ggg acc aag gtg gaa ata aaa                            321
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys                               
            100                 105                                       


<210>  22
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Thr Gly Lys Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  23
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized


<220>
<221>  CDS
<222>  (1)..(321)

<400>  23
gac atc cag atg aca caa tct cct tcc tcc ttg tct gca tct gta gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc acc att act tgc aag gca agt gac cac att aat aat tgg         96
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp           
            20                  25                  30                    

tta gcc tgg tat cag cag aaa cca gga cag gct cct agg ctc tta ata        144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile           
        35                  40                  45                        

tct ggt gca acc agt ttg gaa act ggg gtt cct tca aga ttc agt ggc        192
Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt gga tct gga aag gat ttc act ctc acc att agc agt ctt cag cct        240
Ser Gly Ser Gly Lys Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro           
65                  70                  75                  80            

gaa gat ttt gct acg tat tac tgt caa cag tat tgg agt act ccg tac        288
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Tyr           
                85                  90                  95                

acg ttc gga ggg ggg acc aag gtg gaa ata aaa                            321
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys                               
            100                 105                                       


<210>  24
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  25
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized


<220>
<221>  CDS
<222>  (1)..(321)

<400>  25
gac atc cag atg aca caa tct cct tcc tcc ttg tct gca tct gta gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc acc att act tgc aag gca agt gac cac att aat aat tgg         96
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp           
            20                  25                  30                    

tta gcc tgg tat cag cag aaa cca gga cag gct cct agg ctc tta ata        144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile           
        35                  40                  45                        

tct ggt gca acc agt ttg gaa act ggg gtt cct tca aga ttc agt ggc        192
Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt gga tct gga aca gat ttc act ctc acc att agc agt ctt cag cct        240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro           
65                  70                  75                  80            

gaa gat ttt gct acg tat tac tgt caa cag tat tgg agt act ccg tac        288
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Tyr           
                85                  90                  95                

acg ttc gga ggg ggg acc aag gtg gaa ata aaa                            321
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys                               
            100                 105                                       


<210>  26
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  27
<211>  9
<212>  PRT
<213>  affinity matured

<400>  27

Ser Thr Thr Val Ser Pro Ala Asp Phe 
1               5                   


<210>  28
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  28

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Lys Gln Ala Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Thr Thr Val Ser Pro Ala Asp Phe Arg Gly Thr Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  29

Ser Thr Thr Val Ser Pro Pro Pro Ile 
1               5                   


<210>  30
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  30

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Lys Gln Ala Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Thr Thr Val Ser Pro Pro Pro Ile Trp Gly Thr Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  31

Ser Thr Thr Val Ser Pro Pro Ala His 
1               5                   


<210>  32
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  32

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Lys Gln Ala Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Lys Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Thr Thr Val Ser Pro Pro Ala His Trp Gly Thr Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  33

Ser Thr Thr Val Ala Pro Pro Arg Leu 
1               5                   


<210>  34
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  34

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Lys Gln Ala Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Thr Thr Val Ala Pro Pro Arg Leu Trp Gly Thr Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  35

Ser Thr Thr Val His Pro Asp Arg Asn 
1               5                   


<210>  36
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  36

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Lys Gln Ala Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Thr Thr Val His Pro Asp Arg Asn Trp Gly Thr Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  37
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  37

Ser Thr Thr Val Ser Pro Pro Ala Leu 
1               5                   


<210>  38
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  38

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Lys Gln Ala Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Thr Thr Val Ser Pro Pro Ala Leu Trp Gly Thr Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  39

Ser Thr Thr Val His Pro Asp His Asn 
1               5                   


<210>  40
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  40

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Lys Gln Ala Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Thr Thr Val His Pro Asp His Asn Trp Gly Thr Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  41

Ser Thr Thr Val Ser Pro Pro His Leu 
1               5                   


<210>  42
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  42

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Pro Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Lys Gln Ala Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Thr Thr Val Ser Pro Pro His Leu Trp Gly Thr Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  43
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  43

Ser Thr Thr Val Ala Pro Pro Pro Leu 
1               5                   


<210>  44
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  44

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Lys Gln Ala Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Thr Thr Val Ala Pro Pro Pro Leu Trp Gly Thr Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  45

Ser Thr Thr Val Ser Pro Pro His Leu 
1               5                   


<210>  46
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  46

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Lys Gln Ala Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Thr Thr Val Ser Pro Pro His Leu Trp Gly Thr Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  47

Ser Thr Thr Val Ala Pro Pro Gly His 
1               5                   


<210>  48
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  48

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Lys Gln Ala Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Thr Thr Val Ala Pro Pro Gly His Trp Gly Thr Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  49
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  49

Ser Thr Thr Val Ser Pro Pro Arg Val 
1               5                   


<210>  50
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  50

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Lys Gln Ala Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Thr Thr Val Ser Pro Pro Arg Val Trp Gly Thr Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  51
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  51

Ser Thr Thr Val Ser Pro Pro Pro Leu 
1               5                   


<210>  52
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  52

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Lys Gln Ala Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Thr Thr Val Ser Pro Pro Pro Leu Trp Gly Thr Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  53

Ser Thr Thr Val Ala Pro Pro Ala His 
1               5                   


<210>  54
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  54

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Lys Gln Ala Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Thr Thr Val Ala Pro Pro Ala His Trp Gly Thr Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  55
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  55

Ser Thr Thr Val Arg Pro Pro Gly Ile 
1               5                   


<210>  56
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  56

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Lys Gln Ala Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Thr Thr Val Arg Pro Pro Gly Ile Trp Gly Thr Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  57
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  57

Ser Thr Thr Val Ser Ala Pro Gly Val 
1               5                   


<210>  58
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  58

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Lys Gln Ala Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Thr Thr Val Ser Ala Pro Gly Val Trp Gly Thr Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  59
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  59

Asn Thr Tyr Gly Asn Asn Pro His Thr 
1               5                   


<210>  60
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  60

Asp Ile Gln Met Thr Gln Ser Pro Ser Tyr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Thr Gly Lys Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Asn Thr Tyr Gly Asn Asn Pro His 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  61
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  61

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Thr Gly Lys Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Asn Thr Tyr Gly Asn Asn Pro His 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  62
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  62

His Gln Tyr Tyr Asn Thr Pro Tyr Thr 
1               5                   


<210>  63
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  63

Asp Ile Gln Met Thr Gln Ser Pro Ser Tyr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Thr Gly Lys Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Asn Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  64
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  64

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Thr Gly Lys Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Asn Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  65
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  65

His Gln Tyr Tyr Ser Thr Pro Tyr Thr 
1               5                   


<210>  66
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  66

Asp Ile Gln Met Thr Gln Ser Pro Ser Tyr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Thr Gly Lys Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  67
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  67

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Thr Gly Lys Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  68
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  68

Gln Gln Tyr Tyr Ser Thr Pro Tyr Thr 
1               5                   


<210>  69
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  69

Asp Ile Gln Met Thr Gln Ser Pro Ser Tyr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Thr Gly Lys Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  70
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  affinity matured

<400>  70

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Thr Gly Lys Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  71
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is a, c, g, or t

<400>  71
kncnncnncn ncsvcnwcyg g                                                 21


<210>  72
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  72
tgtmrsvmgt vskrsrrcwm cyycbwcryc ttc                                    33


<210>  73
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  residue is A R or S

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  residue is G or R

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  residue is I L or V

<400>  73

Val Xaa Pro Pro Xaa Xaa 
1               5       


<210>  74
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus


<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  residue is A or R or S

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  residue is G or R

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  residue is I L or V

<400>  74

Ser Thr Thr Val Xaa Pro Pro Xaa Xaa 
1               5                   


<210>  75
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  residue is A R or S

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  residue is A G H P or R

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  residue is H I L or V

<400>  75

Val Xaa Pro Pro Xaa Xaa 
1               5       


<210>  76
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus


<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  residue is A R or S

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  residue is A G H P or R

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  residue is H I L or V

<400>  76

Ser Thr Thr Val Xaa Pro Pro Xaa Xaa 
1               5                   


<210>  77
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  residue is A H R or S

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  residue is A or P

<220>
<221>  VARIANT
<222>  (3)..(4)
<223>  at least one of 3 and 4 is P

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  residue is A D or P

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  residue is A D G H P or R

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  residue is H I L or V

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  residue is F H I L N or V

<400>  77

Val Xaa Xaa Xaa Xaa Xaa 
1               5       


<210>  78
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus


<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  residue is A H R or S

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  residue is A or P

<220>
<221>  VARIANT
<222>  (6)..(7)
<223>  at least one of 6 and 7 is P

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  residue is A D or P

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  residue is A D G H or P

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  residue is F H I L N or V

<400>  78

Ser Thr Thr Val Xaa Xaa Xaa Xaa Xaa 
1               5                   


