                         SEQUENCE LISTING

<110>  Sanofi Pasteur Biologics, LLC
 
<120>  ICP0-MEDIATED ENHANCED EXPRESSION SYSTEM

<130>  1121-5-PCT

<150>  US 62/161,194
<151>  2015-05-13

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer of 3'UTR sequence of pcDNA3.1 used to transfect 
       AV529-19

<400>  1
gccagccatc tgttgtttgc                                                   20


<210>  2
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer of 3'UTR sequence of pcDNA3.1 used to transfect 
       AV529-19

<400>  2
gggagtggca ccttcca                                                      17


<210>  3
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe of 3'UTR sequence of pcDNA3.1 used to transfect AV529-19

<400>  3
ccccgtgcct tcctt                                                        15


<210>  4
<211>  775
<212>  PRT
<213>  Human herpesvirus 1 strain 17

<400>  4

Met Glu Pro Arg Pro Gly Ala Ser Thr Arg Arg Pro Glu Gly Arg Pro 
1               5                   10                  15      


Gln Arg Glu Pro Ala Pro Asp Val Trp Val Phe Pro Cys Asp Arg Asp 
            20                  25                  30          


Leu Pro Asp Ser Ser Asp Ser Glu Ala Glu Thr Glu Val Gly Gly Arg 
        35                  40                  45              


Gly Asp Ala Asp His His Asp Asp Asp Ser Ala Ser Glu Ala Asp Ser 
    50                  55                  60                  


Thr Asp Thr Glu Leu Phe Glu Thr Gly Leu Leu Gly Pro Gln Gly Val 
65                  70                  75                  80  


Asp Gly Gly Ala Val Ser Gly Gly Ser Pro Pro Arg Glu Glu Asp Pro 
                85                  90                  95      


Gly Ser Cys Gly Gly Ala Pro Pro Arg Glu Asp Gly Gly Ser Asp Glu 
            100                 105                 110         


Gly Asp Val Cys Ala Val Cys Thr Asp Glu Ile Ala Pro His Leu Arg 
        115                 120                 125             


Cys Asp Thr Phe Pro Cys Met His Arg Phe Cys Ile Pro Cys Met Lys 
    130                 135                 140                 


Thr Trp Met Gln Leu Arg Asn Thr Cys Pro Leu Cys Asn Ala Lys Leu 
145                 150                 155                 160 


Val Tyr Leu Ile Val Gly Val Thr Pro Ser Gly Ser Phe Ser Thr Ile 
                165                 170                 175     


Pro Ile Val Asn Asp Pro Gln Thr Arg Met Glu Ala Glu Glu Ala Val 
            180                 185                 190         


Arg Ala Gly Thr Ala Val Asp Phe Ile Trp Thr Gly Asn Gln Arg Phe 
        195                 200                 205             


Ala Pro Arg Tyr Leu Thr Leu Gly Gly His Thr Val Arg Ala Leu Ser 
    210                 215                 220                 


Pro Thr His Pro Glu Pro Thr Thr Asp Glu Asp Asp Asp Asp Leu Asp 
225                 230                 235                 240 


Asp Ala Asp Tyr Val Pro Pro Ala Pro Arg Arg Thr Pro Arg Ala Pro 
                245                 250                 255     


Pro Arg Arg Gly Ala Ala Ala Pro Pro Val Thr Gly Gly Ala Ser His 
            260                 265                 270         


Ala Ala Pro Gln Pro Ala Ala Ala Arg Thr Ala Pro Pro Ser Ala Pro 
        275                 280                 285             


Ile Gly Pro His Gly Ser Ser Asn Thr Asn Thr Thr Thr Asn Ser Ser 
    290                 295                 300                 


Gly Gly Gly Gly Ser Arg Gln Ser Arg Ala Ala Ala Pro Arg Gly Ala 
305                 310                 315                 320 


Ser Gly Pro Ser Gly Gly Val Gly Val Gly Val Gly Val Val Glu Ala 
                325                 330                 335     


Glu Ala Gly Arg Pro Arg Gly Arg Thr Gly Pro Leu Val Asn Arg Pro 
            340                 345                 350         


Ala Pro Leu Ala Asn Asn Arg Asp Pro Ile Val Ile Ser Asp Ser Pro 
        355                 360                 365             


Pro Ala Ser Pro His Arg Pro Pro Ala Ala Pro Met Pro Gly Ser Ala 
    370                 375                 380                 


Pro Arg Pro Gly Pro Pro Ala Ser Ala Ala Ala Ser Gly Pro Ala Arg 
385                 390                 395                 400 


Pro Arg Ala Ala Val Ala Pro Cys Val Arg Ala Pro Pro Pro Gly Pro 
                405                 410                 415     


Gly Pro Arg Ala Pro Ala Pro Gly Ala Glu Pro Ala Ala Arg Pro Ala 
            420                 425                 430         


Asp Ala Arg Arg Val Pro Gln Ser His Ser Ser Leu Ala Gln Ala Ala 
        435                 440                 445             


Asn Gln Glu Gln Ser Leu Cys Arg Ala Arg Ala Thr Val Ala Arg Gly 
    450                 455                 460                 


Ser Gly Gly Pro Gly Val Glu Gly Gly His Gly Pro Ser Arg Gly Ala 
465                 470                 475                 480 


Ala Pro Ser Gly Ala Ala Pro Leu Pro Ser Ala Ala Ser Val Glu Gln 
                485                 490                 495     


Glu Ala Ala Val Arg Pro Arg Lys Arg Arg Gly Ser Gly Gln Glu Asn 
            500                 505                 510         


Pro Ser Pro Gln Ser Thr Arg Pro Pro Leu Ala Pro Ala Gly Ala Lys 
        515                 520                 525             


Arg Ala Ala Thr His Pro Pro Ser Asp Ser Gly Pro Gly Gly Arg Gly 
    530                 535                 540                 


Gln Gly Gly Pro Gly Thr Pro Leu Thr Ser Ser Ala Ala Ser Ala Ser 
545                 550                 555                 560 


Ser Ser Ser Ala Ser Ser Ser Ser Ala Pro Thr Pro Ala Gly Ala Ala 
                565                 570                 575     


Ser Ser Ala Ala Gly Ala Ala Ser Ser Ser Ala Ser Ala Ser Ser Gly 
            580                 585                 590         


Gly Ala Val Gly Ala Leu Gly Gly Arg Gln Glu Glu Thr Ser Leu Gly 
        595                 600                 605             


Pro Arg Ala Ala Ser Gly Pro Arg Gly Pro Arg Lys Cys Ala Arg Lys 
    610                 615                 620                 


Thr Arg His Ala Glu Thr Ser Gly Ala Val Pro Ala Gly Gly Leu Thr 
625                 630                 635                 640 


Arg Tyr Leu Pro Ile Ser Gly Val Ser Ser Val Val Ala Leu Ser Pro 
                645                 650                 655     


Tyr Val Asn Lys Thr Ile Thr Gly Asp Cys Leu Pro Ile Leu Asp Met 
            660                 665                 670         


Glu Thr Gly Asn Ile Gly Ala Tyr Val Val Leu Val Asp Gln Thr Gly 
        675                 680                 685             


Asn Met Ala Thr Arg Leu Arg Ala Ala Val Pro Gly Trp Ser Arg Arg 
    690                 695                 700                 


Thr Leu Leu Pro Glu Thr Ala Gly Asn His Val Met Pro Pro Glu Tyr 
705                 710                 715                 720 


Pro Thr Ala Pro Ala Ser Glu Trp Asn Ser Leu Trp Met Thr Pro Val 
                725                 730                 735     


Gly Asn Met Leu Phe Asp Gln Gly Thr Leu Val Gly Ala Leu Asp Phe 
            740                 745                 750         


Arg Ser Leu Arg Ser Arg His Pro Trp Ser Gly Glu Gln Gly Ala Ser 
        755                 760                 765             


Thr Arg Asp Glu Gly Lys Gln 
    770                 775 


<210>  5
<211>  825
<212>  PRT
<213>  Human herpesvirus 2 strain HG52

<400>  5

Met Glu Pro Arg Pro Gly Thr Ser Ser Arg Ala Asp Pro Gly Pro Glu 
1               5                   10                  15      


Arg Pro Pro Arg Gln Thr Pro Gly Thr Gln Pro Ala Ala Pro His Ala 
            20                  25                  30          


Trp Gly Met Leu Asn Asp Met Gln Trp Leu Ala Ser Ser Asp Ser Glu 
        35                  40                  45              


Glu Glu Thr Glu Val Gly Ile Ser Asp Asp Asp Leu His Arg Asp Ser 
    50                  55                  60                  


Thr Ser Glu Ala Gly Ser Thr Asp Thr Glu Met Phe Glu Ala Gly Leu 
65                  70                  75                  80  


Met Asp Ala Ala Thr Pro Pro Ala Arg Pro Pro Ala Glu Arg Gln Gly 
                85                  90                  95      


Ser Pro Thr Pro Ala Asp Ala Gln Gly Ser Cys Gly Gly Gly Pro Val 
            100                 105                 110         


Gly Glu Glu Glu Ala Glu Ala Gly Gly Gly Gly Asp Val Cys Ala Val 
        115                 120                 125             


Cys Thr Asp Glu Ile Ala Pro Pro Leu Arg Cys Gln Ser Phe Pro Cys 
    130                 135                 140                 


Leu His Pro Phe Cys Ile Pro Cys Met Lys Thr Trp Ile Pro Leu Arg 
145                 150                 155                 160 


Asn Thr Cys Pro Leu Cys Asn Thr Pro Val Ala Tyr Leu Ile Val Gly 
                165                 170                 175     


Val Thr Ala Ser Gly Ser Phe Ser Thr Ile Pro Ile Val Asn Asp Pro 
            180                 185                 190         


Arg Thr Arg Val Glu Ala Glu Ala Ala Val Arg Ala Gly Thr Ala Val 
        195                 200                 205             


Asp Phe Ile Trp Thr Gly Asn Pro Arg Thr Ala Pro Arg Ser Leu Ser 
    210                 215                 220                 


Leu Gly Gly His Thr Val Arg Ala Leu Ser Pro Thr Pro Pro Trp Pro 
225                 230                 235                 240 


Gly Thr Asp Asp Glu Asp Asp Asp Leu Ala Asp Val Asp Tyr Val Pro 
                245                 250                 255     


Pro Ala Pro Arg Arg Ala Pro Arg Arg Gly Gly Gly Gly Ala Gly Ala 
            260                 265                 270         


Thr Arg Gly Thr Ser Gln Pro Ala Ala Thr Arg Pro Ala Pro Pro Gly 
        275                 280                 285             


Ala Pro Arg Ser Ser Ser Ser Gly Gly Ala Pro Leu Arg Ala Gly Val 
    290                 295                 300                 


Gly Ser Gly Ser Gly Gly Gly Pro Ala Val Ala Ala Val Val Pro Arg 
305                 310                 315                 320 


Val Ala Ser Leu Pro Pro Ala Ala Gly Gly Gly Arg Ala Gln Ala Arg 
                325                 330                 335     


Arg Val Gly Glu Asp Ala Ala Ala Ala Glu Gly Arg Thr Pro Pro Ala 
            340                 345                 350         


Arg Gln Pro Arg Ala Ala Gln Glu Pro Pro Ile Val Ile Ser Asp Ser 
        355                 360                 365             


Pro Pro Pro Ser Pro Arg Arg Pro Ala Gly Pro Gly Pro Leu Ser Phe 
    370                 375                 380                 


Val Ser Ser Ser Ser Ala Gln Val Ser Ser Gly Pro Gly Gly Gly Gly 
385                 390                 395                 400 


Leu Pro Gln Ser Ser Gly Arg Ala Ala Arg Pro Arg Ala Ala Val Ala 
                405                 410                 415     


Pro Arg Val Arg Ser Pro Pro Arg Ala Ala Ala Ala Pro Val Val Ser 
            420                 425                 430         


Ala Ser Ala Asp Ala Ala Gly Pro Ala Pro Pro Ala Val Pro Val Asp 
        435                 440                 445             


Ala His Arg Ala Pro Arg Ser Arg Met Thr Gln Ala Gln Thr Asp Thr 
    450                 455                 460                 


Gln Ala Gln Ser Leu Gly Arg Ala Gly Ala Thr Asp Ala Arg Gly Ser 
465                 470                 475                 480 


Gly Gly Pro Gly Ala Glu Gly Gly Pro Gly Val Pro Arg Gly Thr Asn 
                485                 490                 495     


Thr Pro Gly Ala Ala Pro His Ala Ala Glu Gly Ala Ala Ala Arg Pro 
            500                 505                 510         


Arg Lys Arg Arg Gly Ser Asp Ser Gly Pro Ala Ala Ser Ser Ser Ala 
        515                 520                 525             


Ser Ser Ser Ala Ala Pro Arg Ser Pro Leu Ala Pro Gln Gly Val Gly 
    530                 535                 540                 


Ala Lys Arg Ala Ala Pro Arg Arg Ala Pro Asp Ser Asp Ser Gly Asp 
545                 550                 555                 560 


Arg Gly His Gly Pro Leu Ala Pro Ala Ser Ala Gly Ala Ala Pro Pro 
                565                 570                 575     


Ser Ala Ser Pro Ser Ser Gln Ala Ala Val Ala Ala Ala Ser Ser Ser 
            580                 585                 590         


Ser Ala Ser Ser Ser Ser Ala Ser Ser Ser Ser Ala Ser Ser Ser Ser 
        595                 600                 605             


Ala Ser Ser Ser Ser Ala Ser Ser Ser Ser Ala Ser Ser Ser Ser Ala 
    610                 615                 620                 


Ser Ser Ser Ala Gly Gly Ala Gly Gly Ser Val Ala Ser Ala Ser Gly 
625                 630                 635                 640 


Ala Gly Glu Arg Arg Glu Thr Ser Leu Gly Pro Arg Ala Ala Ala Pro 
                645                 650                 655     


Arg Gly Pro Arg Lys Cys Ala Arg Lys Thr Arg His Ala Glu Gly Gly 
            660                 665                 670         


Pro Glu Pro Gly Ala Arg Asp Pro Ala Pro Gly Leu Thr Arg Tyr Leu 
        675                 680                 685             


Pro Ile Ala Gly Val Ser Ser Val Val Ala Leu Ala Pro Tyr Val Asn 
    690                 695                 700                 


Lys Thr Val Thr Gly Asp Cys Leu Pro Val Leu Asp Met Glu Thr Gly 
705                 710                 715                 720 


His Ile Gly Ala Tyr Val Val Leu Val Asp Gln Thr Gly Asn Val Ala 
                725                 730                 735     


Asp Leu Leu Arg Ala Ala Ala Pro Ala Trp Ser Arg Arg Thr Leu Leu 
            740                 745                 750         


Pro Glu His Ala Arg Asn Cys Val Arg Pro Pro Asp Tyr Pro Thr Pro 
        755                 760                 765             


Pro Ala Ser Glu Trp Asn Ser Leu Trp Met Thr Pro Val Gly Asn Met 
    770                 775                 780                 


Leu Phe Asp Gln Gly Thr Leu Val Gly Ala Leu Asp Phe His Gly Leu 
785                 790                 795                 800 


Arg Ser Arg His Pro Trp Ser Arg Glu Gln Gly Ala Pro Ala Pro Ala 
                805                 810                 815     


Gly Asp Ala Pro Ala Gly His Gly Glu 
            820                 825 


<210>  6
<211>  676
<212>  PRT
<213>  Infectious bovine rhinotracheitis virus

<400>  6

Met Ala Pro Pro Ala Ala Ala Pro Glu Leu Gly Ser Cys Cys Ile Cys 
1               5                   10                  15      


Leu Asp Ala Ile Thr Gly Ala Ala Arg Ala Leu Pro Cys Leu His Ala 
            20                  25                  30          


Phe Cys Leu Ala Cys Ile Arg Arg Trp Leu Glu Gly Arg Pro Thr Cys 
        35                  40                  45              


Pro Leu Cys Lys Ala Pro Val Gln Ser Leu Ile His Ser Val Ala Ser 
    50                  55                  60                  


Asp Glu Cys Phe Glu Glu Ile Pro Val Gly Gly Gly Pro Gly Ala Asp 
65                  70                  75                  80  


Gly Ala Leu Glu Pro Asp Ala Ala Val Ile Trp Gly Glu Asp Tyr Asp 
                85                  90                  95      


Ala Gly Pro Ile Asp Leu Thr Ala Ala Asp Gly Glu Ala Ser Gly Ala 
            100                 105                 110         


Gly Gly Glu Ala Gly Ala Ala Asp Gly Ser Glu Ala Gly Gly Gly Ala 
        115                 120                 125             


Gly Gly Ala Glu Glu Ala Gly Glu Ala Arg Gly Ala Gly Ala Gly Arg 
    130                 135                 140                 


Ala Ala Gly Ala Ala Gly Gly Arg Ala Gly Arg Gly Ala Asp Ala Ala 
145                 150                 155                 160 


Gln Glu Phe Ile Asp Arg Val Ala Arg Gly Pro Arg Leu Pro Leu Leu 
                165                 170                 175     


Pro Asn Thr Pro Glu His Gly Pro Gly Ala Pro Tyr Leu Arg Arg Val 
            180                 185                 190         


Val Glu Trp Val Glu Gly Ala Leu Val Gly Ser Phe Ala Val Thr Ala 
        195                 200                 205             


Arg Glu Leu Ala Ala Met Thr Asp Tyr Val Met Ala Met Leu Ala Glu 
    210                 215                 220                 


Cys Gly Phe Asp Asp Asp Gly Leu Ala Asp Ala Met Glu Pro Leu Ile 
225                 230                 235                 240 


Gly Glu Asp Asp Ala Pro Ala Phe Val Arg Ser Leu Leu Phe Val Ala 
                245                 250                 255     


Ala Arg Cys Val Thr Val Gly Pro Ser His Leu Ile Pro Gln Gln Ser 
            260                 265                 270         


Ala Pro Pro Gly Gly Arg Gly Val Val Phe Leu Asp Thr Ser Asp Ser 
        275                 280                 285             


Asp Ser Glu Gly Ser Glu Asp Asp Ser Trp Ser Glu Ser Glu Glu Ser 
    290                 295                 300                 


Ser Ser Gly Leu Ser Thr Ser Asp Leu Thr Ala Ile Asp Asp Thr Glu 
305                 310                 315                 320 


Thr Glu Pro Glu Thr Asp Ala Glu Val Glu Ser Arg Arg Thr Arg Gly 
                325                 330                 335     


Ala Ser Gly Ala Ala Arg Ala Arg Arg Pro Ala Glu Arg Gln Tyr Val 
            340                 345                 350         


Ser Thr Arg Gly Arg Gln Thr Pro Ala Val Gln Pro Ala Pro Arg Ser 
        355                 360                 365             


Leu Ala Arg Arg Pro Cys Gly Arg Ala Ala Ala Val Ser Ala Pro Pro 
    370                 375                 380                 


Ser Ser Arg Ser Arg Gly Gly Arg Arg Asp Pro Arg Leu Pro Ala Ala 
385                 390                 395                 400 


Pro Arg Ala Ala Pro Ala Ala Gln Ala Arg Ala Cys Ser Pro Glu Pro 
                405                 410                 415     


Arg Glu Glu Gly Arg Gly Ala Gly Leu Gly Val Ala Ala Gly Glu Thr 
            420                 425                 430         


Ala Gly Trp Gly Ala Gly Ser Glu Glu Gly Arg Gly Glu Arg Arg Ala 
        435                 440                 445             


Arg Leu Leu Gly Glu Ala Gly Pro Pro Arg Val Gln Ala Arg Arg Arg 
    450                 455                 460                 


Arg Arg Thr Glu Leu Asp Arg Ala Pro Thr Pro Ala Pro Ala Pro Ala 
465                 470                 475                 480 


Pro Ala Pro Ala Pro Ile Ser Thr Val Ile Asp Leu Thr Ala Asn Ala 
                485                 490                 495     


Pro Ala Arg Pro Ala Asp Pro Ala Pro Ala Ala Ala Pro Gly Pro Ala 
            500                 505                 510         


Ser Ala Gly Ala Gln Ile Gly Thr Pro Ala Ala Ala Ala Ala Val Thr 
        515                 520                 525             


Ala Ala Ala Ala Ala Pro Ser Val Ala Arg Ser Ser Ala Pro Ser Pro 
    530                 535                 540                 


Ala Val Thr Ala Ala Ala Thr Ser Thr Ala Ala Ala Ile Ser Thr Arg 
545                 550                 555                 560 


Ala Pro Thr Pro Ser Pro Ala Gly Arg Ala Pro Ala Ala Asp Pro Arg 
                565                 570                 575     


Arg Ala Gly Ala Pro Ala Leu Ala Gly Ala Ala Arg Ala Glu Val Gly 
            580                 585                 590         


Arg Asn Gly Asn Pro Gly Arg Glu Arg Arg Pro Ala Ser Ala Met Ala 
        595                 600                 605             


Arg Gly Asp Leu Asp Pro Gly Pro Glu Ser Ser Ala Gln Lys Arg Arg 
    610                 615                 620                 


Arg Thr Glu Met Glu Val Ala Ala Trp Val Arg Glu Ser Leu Leu Gly 
625                 630                 635                 640 


Thr Pro Arg Arg Ser Ser Ala Ala Leu Ala Pro Gln Pro Gly Gly Arg 
                645                 650                 655     


Gln Gly Pro Ser Leu Ala Gly Leu Leu Gly Arg Cys Ser Gly Gly Ser 
            660                 665                 670         


Ala Trp Arg Gln 
        675     


