                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
 
<120>  AAV ISOLATE AND FUSION PROTEIN COMPRISING NERVE GROWTH FACTOR 
       SIGNAL PEPTIDE AND PARATHYROID HORMONE

<130>  724284

<150>  US 62/160,552
<151>  2015-05-12

<150>  US 62/331,699
<151>  2016-05-04

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Met Ser Met Leu Phe Tyr Thr Leu Ile Thr Ala Phe Leu Ile Gly Val 
1               5                   10                  15      


Gln Ala Glu Pro Tyr Thr Asp Ser Asn Val Pro Glu Gly Asp Ser Val 
            20                  25                  30          


Pro Glu Ala His Trp Thr Lys Leu Gln His Ser Leu Asp Thr Ala Leu 
        35                  40                  45              


Arg Arg Ala Arg Ser Ala Pro Thr Ala Pro Ile Ala Ala Arg Val Thr 
    50                  55                  60                  


Gly Gln Thr Arg Asn Ile Thr Val Asp Pro Arg Leu Phe Lys Lys Arg 
65                  70                  75                  80  


Arg Leu His Ser Pro Arg Val Leu Phe Ser Thr Gln Pro Pro Pro Thr 
                85                  90                  95      


Ser Ser Asp Thr Leu Asp Leu Asp Phe Gln Ala His Gly Thr Ile Pro 
            100                 105                 110         


Phe Asn Arg Thr His Arg Ser Lys Arg 
        115                 120     


<210>  2
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe Val Ala Leu Gly Ala Pro Leu Ala Pro Arg Asp Ala Gly Ser 
        35                  40                  45              


Gln Arg Pro Arg Lys Lys Glu Asp Asn Val Leu Val Glu Ser His Glu 
    50                  55                  60                  


Lys Ser Leu Gly Glu Ala Asp Lys Ala Asp Val Asn Val Leu Thr Lys 
65                  70                  75                  80  


Ala Lys Ser Gln 
                


<210>  3
<211>  1259
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
ctcaatgggc gtggatagcg gtttgactca cggggatttc caagtctcca ccccattgac       60

gtcaatggga gtttgttttg gcaccaaaat caacgggact ttccaaaatg tcgtaacaac      120

tccgccccat tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta tataagcaga      180

gctggtttag tgaaccgtca gatccgctag cccaccatgt ccatgttgtt ctacactctg      240

atcactgcgt ttttgatcgg cgtacaggca gaaccgtaca cagatagcaa tgtcccagaa      300

ggagactctg tccctgaagc ccactggact aaacttcagc attcccttga cacagccctc      360

cgcagagccc gcagtgcccc tactgcacca atagctgccc gagtgacagg gcagacccgc      420

aacatcactg tagaccccag actgtttaag aaacggagac tccactcacc ccgtgtgctg      480

ttcagcaccc agcctccacc cacctcttca gacactctgg atctagactt ccaggcccac      540

ggtacaatcc ctttcaacag gactcaccgg agcaagcgct ctgtgagtga aatacagctt      600

atgcataacc tgggaaaaca tctgaactcg atggagagag tagaatggct gcgtaagaag      660

ctgcaggatg tgcacaattt tgttgccctt ggagctcctc tagctcccag agatgctggt      720

tcccagaggc cccgaaaaaa ggaagacaat gtcttggttg agagccatga aaaaagtctt      780

ggagaggcag acaaagctga tgtgaatgta ttaactaaag ctaaatccca gtagctcgac      840

ctgcaggcat gcaagcttgg gatctttgtg aaggaacctt acttctgtgg tgtgacataa      900

ttggacaaac tacctacaga gatttaaagc tctaaggtaa atataaaatt tttaagtgta      960

taatgtgtta aactactgat tctaattgtt tgtgtatttt agattcacag tcccaaggct     1020

catttcagcc cctcagtcct cacagtctgt tcatgatcat atcagcatac cacattttgt     1080

agaggtttac tgctttaaaa acctcccaca cctccccctg aacctgaaac ataaaatgat     1140

gcattgttgt tgttacttgt ttatgcagct atatgtacaa taaagcatac attcaaatca     1200

caataagcat tttccggcat tcagtttggt tgttcaactc tatcaatggt atcctgtag      1259


<210>  4
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Ser Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Ala Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  5
<211>  3695
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5
ctctttgcgc ttgcgttttc ccttgtccag atagcccagt agctgacatt catccggggt       60

cagcaccgtt tctgcggact ggctttctac gtgaaaagga tctaggtgaa gatccttttt      120

gataatctca tgcctgacat ttatattccc cagaacatca ggttaatggc gtttttgatg      180

tcattttcgc ggtggctgag atcagccact tcttccccga taacggagac cggcacactg      240

gccatatcgg tggtcatcat gcgccagctt tcatccccga tatgcaccac cgggtaaagt      300

tcacgggaga ctttatctga cagcagacgt gcactggcca gggggatcac catccgtcgc      360

cccggcgtgt caataatatc actctgtaca tccacaaaca gacgataacg gctctctctt      420

ttataggtgt aaaccttaaa ctgccgtacg tataggctgc gcaactgttg ggaagggcga      480

tcggtgcggg cctcttcgct attacgccag ctggcgaaag ggggatgtgc tgcaaggcga      540

ttaagttggg taacgccagg gttttcccag tcacgacgtt gtaaaacgac ggccagtgaa      600

ttgtaatacg actcactata gggcgaattg aatttagcgg ccgcgaattc gcccttatga      660

tatctggtgg gaggagggca agatgacggc caaggtcgtg gagtccgcca aggccattct      720

cggcggcagc aaagtgcgcg tggaccaaaa gtgcaagtcg tccgcccaga tcgatcccac      780

tcccgtcatt gtcacctcca acaccaacat gtgcgccgtg attgacggga acagcaccac      840

cttcgagcac cagcagccgt tgcaggaccg gatgttcaaa tttgaactta cccgccgtct      900

ggagcatgac tttggcaagg tgacaaagca ggaagtcaaa gagttcttcc gctgggcgca      960

ggatcacgtg accgaggtgg cgcatgagtt ccacgtcaga aagggtggag ccaacaagag     1020

acccgccccc gatgacgctg ataaaagcga gcccaagcgg gcctgcccct cagtcgcaga     1080

tccatcgacg tcagacgcgg aaggagctcc ggtggacttt gccgacaggt accaaaacaa     1140

atgttctcgt cacgcgggca tgcttcagat gctgtttccc tgcaagacat gcgagagaat     1200

gaatcagaat ttcaacattt gcttcacgca cgggaccagg gactgttcgg agtgcttccc     1260

cggcgtgtca gaatctcaac cggtcgtcag aaaaaggacg tatcggaaac tctgtgccat     1320

tcatcatctg ctggggaggg ctcccgagat tgcttgctcg gcctgcgatc tggtcaacgt     1380

ggacctggat gactgtgtct ctgagcaata aatgacttaa accaggtatg gctgccgatg     1440

gttatcttcc agattggctc gaggacaacc tctctgaggg cattcgcgag tggtgggact     1500

tgaaacctgg agccccgaaa cccaaagcca accagcaaaa gcaggacgac ggccggggtc     1560

tggtgcttcc tggctacaag tacctcggac ccttcaacgg actcgacaag ggggagcccg     1620

tcaacgcggc ggacgcagcg gccctcgagc acgacaaggc ctacgaccag cagctcaaag     1680

cgggtgacaa tccgtacctg cggtataacc acgccgacgc cgagtttcag gagcgtctgc     1740

aagaagatac gtcttttggg ggcaacctcg ggcgagcagt cttccaggcc aagaagcggg     1800

ttctcgaacc tctcggtctg gttgaggaag gcgctaagac ggctcctgga aagaagagac     1860

cggtagagca gtcaccccaa gaaccagact cctcatcggg catcggcaag acaggccagc     1920

agcccgctaa aaagagactc aattttggtc agactggcga cacagagtca gtccccgacc     1980

cacaacctct cggagaacct ccagcagccc cctcaggtct gggacctaat acaatggctt     2040

caggcggtgg cgctccaatg gcagacaata acgaaggcgc cgacggagtg ggtaattcct     2100

cgggaaattg gcattgcgat tccacatggc tgggggacag agtcatcacc accagcaccc     2160

gaacctgggc cctgcccacc tacaacaacc acctctacaa gcaaatctcc aacggcacct     2220

cgggaggaag caccaacgac aacacctact ttggctacag caccccctgg gggtattttg     2280

acttcaacag attccactgc cacttttcac cacgtgactg gcagcgactc atcaacaaca     2340

attggggatt ccggcccaag agactcaact tcaagctctt caacatccag gtcaaggaag     2400

tcacgacgaa cgaaggcacc aagaccatcg ccaataatct caccagcacc gtgcaggtct     2460

ttacggactc ggagtaccag ctaccgtacg tgctaggatc agctcaccag ggatgtctgc     2520

ctccgttccc ggcggacgtc ttcatggttc ctcagtacgg ttatctaact ctgaacaatg     2580

gcagccaggc cctgggacgt tcctccttct actgcctgga gtatttccca tcgcagatgc     2640

tgagaaccgg caacaacttt cagttcagct acaccttcga ggacgtgcct ttccacagca     2700

gctacgcgca cagccaaagc ctggacaggc tgatgaatcc cctcatcgac cagtacctgt     2760

attacctggt cagaacgcag acaaccggga ctggagggac gcagactctg gcattcagcc     2820

aagcaggccc tagctcaatg gccagccagg ctagaaactg ggtgcccgga ccgagctacc     2880

ggcagcagcg cgtctccacg acaaccaacc agaacaacaa cagcaacttt gcctggacgg     2940

gagctgccaa atttaaactg aacggccgag actctctaat gaaccccggc gtggccatgg     3000

cttcacacaa ggatgacgag gaccgcttct tcccttctag cggggtcctg attttcggca     3060

agcaaggagc cgggaatgat ggagtggatt acagccaagt gctgattaca gatgaggaag     3120

aaatcaaggc taccaacccc gtggcaacag aggaatatgg agcagtggcc atcaacaacc     3180

aggccgctaa tacgcaggcg cagaccggac tcgtgcacaa ccagggggtg attcccggca     3240

tggtgtggca gaacagagac gtgtacctgc agggtcccat ctgggccaaa attcctcaca     3300

cggacggcaa ctttcacccg tctcccctga tgggcggctt tggactgaag cacccgcctc     3360

ctcaaattct catcaagaac acaccggttc cagcggaccc gccgcttacc ttcaaccagg     3420

ccaagctgaa ctctttcatc acgcagtaca gcaccggaca ggtcagcgtg gaaatcgagt     3480

gggagctgca gaaagaaaac agcaaacgct ggaatccaga gattcagtac acttccaact     3540

actacaaatc tacaaatgtg gactttgctg tcaacacgga aggagtgtat agcgagcctc     3600

gccccattgg cacccgttac ctcacccgca acctgtaatt gcctgttaat caataaaccg     3660

gttaattcgt ttcagtaagg aagaattcgt ttaaa                                3695


<210>  6
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Ala Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  7
<211>  365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
atgtccatgt tgttctacac tctgatcact gcgtttttga tcggcgtaca ggcagaaccg       60

tacacagata gcaatgtccc agaaggagac tctgtccctg aagcccactg gactaaactt      120

cagcattccc ttgacacagc cctccgcaga gcccgcagtg cccctactgc accaatagct      180

gcccgagtga cagggcagac ccgcaacatc actgtagacc ccagactgtt taagaaacgg      240

agactccact caccccgtgt gctgttcagc acccagcctc cacccacctc ttcagacact      300

ctggatctag acttccaggc ccacggtaca atccctttca acaggactca ccggagcaag      360

cgctc                                                                  365


<210>  8
<211>  304
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8
tctgtgagtg aaatacagct tatgcataac ctgggaaaac atctgaactc gatggagaga       60

gtagaatggc tgcgtaagaa gctgcaggat gtgcacaatt ttgttgccct tggagctcct      120

ctagctccca gagatgctgg ttcccagagg ccccgaaaaa aggaagacaa tgtcttggtt      180

gagagccatg aaaaaagtct tggagaggca gacaaagctg atgtgaatgt attaactaaa      240

gctaaatccc agtagctcga cctgcaggca tgcaagcttg ggatctttgt gaaggaacct      300

tact                                                                   304


<210>  9
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Asn Met Ala Ser Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Ala Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  10
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10
aagcaggccc tagcaacatg gccagcc                                           27


<210>  11
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  12
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Met Arg Phe Pro Ser Ile Phe Ala Val Val Phe Ala Ala Ser Ser Ala 
1               5                   10                  15      


Leu Ala Ala Pro Ala Asn Thr Thr Ala Glu Asp Glu Thr Ala Gln Ile 
            20                  25                  30          


Pro Ala Glu Ala Val Ile Gly Tyr Leu Gly Leu Glu Gly Asp Ser Asp 
        35                  40                  45              


Val Ala Ala Leu Pro Leu Ser Asp Ser Thr Asn Asn Gly Leu Ser Leu 
    50                  55                  60                  


Ser Thr Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val 
65                  70                  75                  80  


Gln Leu Asp Lys Arg 
                85  


