                         SEQUENCE LISTING

<110>  Ablynx N.V.
 
<120>  T CELL RECRUITING POLYPEPTIDES BASED ON TCR ALPHA/BETA REACTIVITY

<130>  P15-005-PCT-1

<150>  US 62/160,757
<151>  2015-05-13

<150>  US 62/319,486
<151>  2016-04-07

<160>  487   

<170>  PatentIn version 3.5

<210>  1
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Thr Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val His Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  2
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Gly Leu Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Thr Thr Asp Tyr Ala Asp Tyr Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Arg Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  3
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Pro Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  4
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  4

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Thr Thr Asp Tyr Ala Asp Tyr Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Arg Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  5
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  6
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  6

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Thr Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  7
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Val His Leu Leu Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Ala Thr Asp Tyr Ser His Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  8
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Ala Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Thr Pro Glu Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Asp Val Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Val Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  9
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Arg Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Glu Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  10
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  11
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  12
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  12

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Gln Ala Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  13
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Ser Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  14
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Leu Leu Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Ser Ile Ala Asp Ala Thr Asp Tyr Ala His Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Arg Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  15
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Arg Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Val Tyr Ala Glu Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  16
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Leu Leu Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Cys Pro Gly Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Ala Thr Asp Tyr Ser His Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  17
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Pro Ser Cys Ala Ala Ser Gly Ser Val His Leu Leu Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Ala Thr Asp Tyr Ala His Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  18
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Leu Leu Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Ala Thr Asp Tyr Ala His Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  19
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Ala Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Thr Pro Glu Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Glu Val Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Val Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  20
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val His Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp His Arg Gln Pro Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Val Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  21
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  21

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Val Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val His Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  22
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asn Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  23
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp His Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Val Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  24
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  24

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Gly Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  25
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  25

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Glu Val Tyr Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Val Ala Asp Tyr Ala Asp Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  26
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  26

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Ala Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Glu Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Glu Val Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Thr Val Tyr Val Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  27
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  27

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Glu Val Tyr Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Val Ala Asp Tyr Ala Asp Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  28
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  28

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Ser Ile Ser Asp Gln Thr Asp Tyr Ala Glu Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Leu Cys Arg 
                85                  90                  95      


Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  29
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  29

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Tyr Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Arg Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  30
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Ala Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  31
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  31

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp His Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  32
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Val Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Ser Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  33
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Ala Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  34
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  34

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Leu Leu Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Ala Thr Asp Tyr Ser His Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  35
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  35

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Val His Leu Leu Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Gly Val Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Ala Thr Asp Tyr Ser His Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  36
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  36

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  37
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  38
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  38

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Glu Val Tyr Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Val Ala Asp Tyr Ala Asp Phe Ala Gln 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  39
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Thr Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  40
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  40

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Leu Leu Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Ala Thr Asp Tyr Ser His Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly His Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  41
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Gln Ala Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Arg Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  42
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Val His Leu Leu Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Val 
        35                  40                  45              


Thr His Ile Thr Ile Ala Asp Ala Thr Asp Tyr Ser His Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  43
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  43

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Ala Thr Asp Tyr Ala Glu Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Pro Lys Asn Met Val His Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Leu Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  44
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  44

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Arg Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  45
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  45

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala Arg Ile Ser Ile Ser Asp Gln Thr Asp Tyr Ala Glu Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Leu Cys Arg 
                85                  90                  95      


Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  46
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  46

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Glu Val Tyr Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Val Ala Asp Tyr Ala Asp Phe Ala Lys 
    50                  55                  60                  


Gly Arg Leu Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  47
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  47

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Pro Cys Ala Ala Ser Gly Ala Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Thr Pro Glu Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Glu Val Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Val Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  48
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  48

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ala Ala Ser Gly Ser Val His Leu Leu Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Ala Thr Asp Tyr Ala His Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  49
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  49

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  50
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  50

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  51
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  51

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Glu Val Tyr Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Ala Ala Asp Tyr Ala Asp Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Gly Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  52
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  52

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Trp Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val Tyr Lys Ile Asn 
            20                  25                  30          


Phe Leu Ser Trp Tyr Arg Gln Ala Pro Gly His Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Ala Ala Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Arg Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Phe Cys His 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  53
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Leu Leu Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Ala Thr Asp Tyr Ser His Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  54
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  54

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Ala Ile Ser Asp Gln Thr Asp Tyr Ala Glu Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Leu Cys Arg 
                85                  90                  95      


Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  55
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  55

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ala Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  56
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  56

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Gly Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  57
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  57

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu His Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  58
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  58

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Arg Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  59
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  59

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Glu Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  60
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  60

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Ala Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Thr Pro Glu Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Glu Val Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Val Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  61
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  61

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Ala Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Glu Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Glu Val Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Thr Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  62
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  62

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Ser Tyr Ala Gly Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  63
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  63

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Ser Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  64
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  64

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Ala Thr Asp Tyr Ala Glu Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Pro Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Leu Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  65
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  65

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Ala Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Thr Pro Glu Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Glu Val Asp Tyr Ala His Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Val Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  66
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  66

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Ala Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Thr Pro Glu Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Glu Val Ala Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Val Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  67
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  67

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Glu Val Tyr Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Ala Ala Asp Tyr Ala Asp Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  68
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  68

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Glu Val Tyr Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Ala Ala Asp Tyr Ala Asp Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  69
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  69

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Pro Ser Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Ser Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  70
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  70

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Glu Val Tyr Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Val Ala Asp Tyr Ala Asp Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Val Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  71
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  71

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  72
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  72

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Glu Val Tyr Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Ala Ala Asp Tyr Ala Asp Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  73
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  73

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Leu Leu Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Val Thr Asp Tyr Ser Tyr Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  74
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  74

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Val Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  75
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  75

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Gly Met Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Ser Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  76
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  76

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Ala Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Thr Pro Glu Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Glu Val Asp Tyr Glu Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Thr Gly Leu Lys Pro Glu Asp Thr Ala Val Tyr Val Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  77
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  77

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Ser Ile Ser Asp Gln Thr Asp Tyr Ala Glu Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Leu Cys Arg 
                85                  90                  95      


Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  78
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  78

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val Tyr Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp His Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  79
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  79

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Arg Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Ile 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Glu Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  80
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  80

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Gly Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  81
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  81

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Ala Thr Asp Tyr Ala Glu Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Pro Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Leu Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Ser Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  82
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  82

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Met Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  83
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  83

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Val Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ala Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  84
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  84

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Glu Val Tyr Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Ala Ala Asp Tyr Ala Asp Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  85
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  85

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Leu Leu Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Ala Thr Asp Tyr Ser His Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Gly Leu Arg Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  86
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  86

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Ala Thr Asp Tyr Ala Glu Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Pro Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Leu Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  87
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  87

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Glu Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Cys Pro Gly Lys Glu Arg Asp Met Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Leu Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  88
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  88

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Leu Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  89
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  89

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Glu Val Tyr Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Gln Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Val Ala Asp Tyr Ala Asp Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  90
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  90

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Ala Thr Asp Tyr Ala Glu Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Pro Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Val Asp Thr Ala Val Tyr Leu Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  91
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  91

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Leu Leu Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Ala Thr Asp Tyr Ser His Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Arg Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  92
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  92

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Pro Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Gln Ala Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  93
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  93

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Ala Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  94
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  94

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Glu Val Tyr Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Val Ala Asp Tyr Ala Asp Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Gly Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  95
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  95

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Cys Gln Ala Pro Gly Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Ser Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  96
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  96

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Ser Ile Ser Asp Gln Thr Asp Tyr Ala Glu Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Ala Ala Val Tyr Leu Cys Arg 
                85                  90                  95      


Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  97
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  97

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Pro Ser Cys Ala Ala Ser Gly Glu Val Tyr Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Val Ala Asp Tyr Ala Asp Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  98
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  98

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Pro Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Gln Ala Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  99
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  99

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Glu Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Asp Met Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Glu Thr Gln Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Leu Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  100
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  100

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  101
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  101

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Gly Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  102
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  102

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp His Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  103
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  103

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp His Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ala Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  104
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  104

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Trp Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  105
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  105

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Thr Ser Gly Glu Thr Phe Lys Ile Asn 
            20                  25                  30          


Ile Trp Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Leu Thr Ile Gly Gly Ala Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Glu Asp Ser Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys Asn 
                85                  90                  95      


Ala Lys Ser Arg Leu Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  106
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  106

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Thr Ser Gly Glu Thr Phe Lys Ile Asn 
            20                  25                  30          


Ile Trp Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Leu Thr Ile Gly Gly Ala Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Glu Asp Ser Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Asn 
                85                  90                  95      


Ala Lys Ser Arg Leu Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  107
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  107

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Thr Ser Gly Glu Thr Phe Lys Ile Asn 
            20                  25                  30          


Ile Trp Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Leu Thr Ile Gly Gly Ala Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Glu Asp Ser Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Asn 
                85                  90                  95      


Ala Lys Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  108
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  108

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Thr Ser Gly Glu Thr Phe Lys Ile Asn 
            20                  25                  30          


Ile Trp Gly Trp Tyr Arg Gln Thr Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Leu Thr Ile Gly Gly Ala Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Glu Asp Ser Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Asn 
                85                  90                  95      


Ala Lys Ser Arg Leu Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  109
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  109

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Thr Ser Gly Gln Thr Phe Lys Ile Asn 
            20                  25                  30          


Ile Trp Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Leu Thr Ile Gly Gly Ala Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Glu Asp Ser Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Asn 
                85                  90                  95      


Ala Lys Ser Arg Leu Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  110
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  110

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Thr Ser Gly Glu Thr Phe Lys Val Asn 
            20                  25                  30          


Ile Trp Gly Trp Tyr Arg Gln Gly Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Leu Thr Ile Gly Gly Ala Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Glu Asp Ser Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Asn 
                85                  90                  95      


Ala Lys Ser Arg Leu Tyr Pro Tyr Asp Tyr Trp Gly Arg Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  111
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  111

Glu Val Gln Leu Val Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ile Thr Ser Gly Glu Thr Phe Lys Ile 
            20                  25                  30          


Asn Ile Trp Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Ser Leu Thr Ile Gly Gly Ala Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Glu Asp Ser Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Asn Ala Lys Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Arg Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  112
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  112

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Thr Ser Gly Glu Thr Phe Lys Ile Asn 
            20                  25                  30          


Ile Trp Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Leu Thr Ile Gly Gly Ala Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Glu Asp Ser Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Asn 
                85                  90                  95      


Ala Lys Ser Arg Leu Tyr Pro Tyr Asp Tyr Trp Asp Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  113
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  113

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Leu Thr Ser Gly Glu Thr Phe Lys Val Asn 
            20                  25                  30          


Ile Trp Gly Trp Tyr Arg Gln Gly Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Leu Thr Ile Gly Gly Ala Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Glu Asp Ser Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Asn 
                85                  90                  95      


Ala Lys Ser Arg Leu Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  114
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  114

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Thr Ser Gly Glu Thr Phe Lys Ile Asn 
            20                  25                  30          


Ile Trp Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Leu Thr Ile Gly Gly Ala Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Glu Asp Ser Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Asn 
                85                  90                  95      


Ala Lys Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Arg Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  115
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  115

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Thr Ser Gly Glu Thr Phe Lys Ile Asn 
            20                  25                  30          


Ile Trp Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Leu Thr Ile Gly Gly Ala Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Glu Asp Ser Ala Lys Asp Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Asn 
                85                  90                  95      


Ala Lys Ser Arg Leu Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  116
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  116

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Glu Ile Gly Arg Ile Asn 
            20                  25                  30          


Phe Tyr Arg Trp Tyr Arg Gln Ala Pro Gly Asn Gln Arg Glu Val Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Ala Asp Lys Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Arg Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys His 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  117
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  117

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Glu Ile Gly Arg Ile Asn 
            20                  25                  30          


Phe Tyr Arg Trp Tyr Arg Gln Ala Pro Gly Asn Gln Arg Gly Val Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Ala Asp Lys Ile Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Arg Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Gly Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys His 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  118
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  118

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Glu Ile Gly Arg Ile Asn 
            20                  25                  30          


Phe Tyr Arg Trp Tyr Arg Gln Ala Pro Gly Asn Gln Arg Glu Val Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Ala Asp Lys Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Arg Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Pro Glu Asn Thr Ala Val Tyr Phe Cys His 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  119
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  119

Gly Ser Val His Lys Ile Asn Phe Leu Gly 
1               5                   10  


<210>  120
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  120

Gly Ser Val His Leu Leu Asn Phe Leu Gly 
1               5                   10  


<210>  121
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  121

Gly Ala Val His Lys Ile Asn Phe Leu Gly 
1               5                   10  


<210>  122
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  122

Gly Asp Val His Lys Ile Asn Ile Leu Gly 
1               5                   10  


<210>  123
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  123

Gly Asp Val His Lys Ile Asn Phe Leu Gly 
1               5                   10  


<210>  124
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  124

Gly Glu Thr Phe Lys Ile Asn Ile Trp Gly 
1               5                   10  


<210>  125
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  125

Gly Asp Val His Lys Ile Asn Val Leu Gly 
1               5                   10  


<210>  126
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  126

Gly Glu Val Tyr Lys Ile Asn Phe Leu Gly 
1               5                   10  


<210>  127
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  127

Gly Gly Val His Lys Ile Asn Ile Leu Gly 
1               5                   10  


<210>  128
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  128

Gly Gln Thr Phe Lys Ile Asn Ile Trp Gly 
1               5                   10  


<210>  129
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  129

Gly Ser Val Tyr Lys Ile Asn Phe Leu Ser 
1               5                   10  


<210>  130
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  130

Gly Glu Ile Gly Arg Ile Asn Phe Tyr Arg 
1               5                   10  


<210>  131
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  131

Gly Glu Thr Phe Lys Val Asn Ile Trp Gly 
1               5                   10  


<210>  132
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  132

Gly Asp Val Tyr Lys Ile Asn Phe Leu Gly 
1               5                   10  


<210>  133
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  133

Gly Glu Val His Lys Ile Asn Ile Leu Gly 
1               5                   10  


<210>  134
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  134

Thr Ile Thr Ile Gly Asp Thr Thr Asp 
1               5                   


<210>  135
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  135

Thr Ile Thr Ile Gly Asp Ala Thr Asp 
1               5                   


<210>  136
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  136

His Ile Thr Ile Ala Asp Ala Thr Asp 
1               5                   


<210>  137
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  137

Thr Ile Thr Ile Gly Asp Asp Val Asp 
1               5                   


<210>  138
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  138

His Ile Thr Ile Gly Asp Ala Thr Asp 
1               5                   


<210>  139
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  139

His Ile Thr Ile Gly Asp Gln Ala Asp 
1               5                   


<210>  140
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  140

His Ile Ser Ile Ala Asp Ala Thr Asp 
1               5                   


<210>  141
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  141

His Ile Thr Ile Gly Asp Ala Thr Val 
1               5                   


<210>  142
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  142

Ser Leu Thr Ile Gly Gly Ala Thr Asp 
1               5                   


<210>  143
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  143

His Ile Thr Ile Gly Asp Glu Val Asp 
1               5                   


<210>  144
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  144

His Ile Thr Ile Gly Asp Val Thr Asp 
1               5                   


<210>  145
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  145

Ser Leu Thr Ile Gly Gly Ala Thr Asn 
1               5                   


<210>  146
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  146

His Ile Thr Ile Gly Asp Ala Thr Asn 
1               5                   


<210>  147
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  147

His Ile Thr Ile Ala Asp Val Ala Asp 
1               5                   


<210>  148
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  148

Thr Ile Thr Ile Gly Asp Glu Val Asp 
1               5                   


<210>  149
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  149

His Ile Ser Ile Ser Asp Gln Thr Asp 
1               5                   


<210>  150
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  150

His Ile Thr Ile Gly Asp Gln Thr Asp 
1               5                   


<210>  151
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  151

His Ile Thr Ile Gly Asp Thr Thr Asp 
1               5                   


<210>  152
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  152

Arg Ile Ser Ile Ser Asp Gln Thr Asp 
1               5                   


<210>  153
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  153

His Ile Ser Ile Gly Asp Gln Thr Asp 
1               5                   


<210>  154
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  154

His Ile Thr Ile Ala Asp Ala Ala Asp 
1               5                   


<210>  155
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  155

Thr Ile Thr Ile Gly Asp Ala Ala Asp 
1               5                   


<210>  156
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  156

His Ile Ala Ile Ser Asp Gln Thr Asp 
1               5                   


<210>  157
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  157

Thr Ile Thr Ile Ala Asp Lys Thr Asp 
1               5                   


<210>  158
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  158

Thr Ile Thr Ile Ala Asp Lys Ile Asp 
1               5                   


<210>  159
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  159

His Ile Thr Ile Gly Asp Ala Thr Ser 
1               5                   


<210>  160
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  160

Thr Ile Thr Ile Gly Asp Glu Val Ala 
1               5                   


<210>  161
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  161

His Ile Thr Ile Ala Asp Val Thr Asp 
1               5                   


<210>  162
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  162

His Ile Thr Ile Ala Asp Gln Ala Asp 
1               5                   


<210>  163
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  163

Thr Ile Thr Ile Gly Asp Glu Thr Gln 
1               5                   


<210>  164
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  164

Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr 
1               5                   


<210>  165
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  165

Gly Ser Arg Ile Tyr Pro Tyr Asp Tyr 
1               5                   


<210>  166
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  166

Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr 
1               5                   


<210>  167
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  167

Lys Ser Arg Leu Tyr Pro Tyr Asp Tyr 
1               5                   


<210>  168
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  168

Lys Ser Arg Ile Tyr Pro Tyr Asp Tyr 
1               5                   


<210>  169
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  169

Gly Ser Arg Ile Trp Pro Tyr Asp Tyr 
1               5                   


<210>  170
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  170

Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr 
1               5                   


<210>  171
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  171

Gly Ser Arg Ile Tyr Pro Tyr Asn Tyr 
1               5                   


<210>  172
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  172

Gly Ser Arg Leu Tyr Pro Tyr Asp Tyr 
1               5                   


<210>  173
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  173

Gly Ser Arg Ile Tyr Pro Tyr Ser Tyr 
1               5                   


<210>  174
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  174

Leu Ser Arg Leu Tyr Pro Tyr Asn Tyr 
1               5                   


<210>  175
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  175

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  176
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  176

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Pro Cys Ala Ala Ser 
            20                  25  


<210>  177
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  177

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser 
            20                  25  


<210>  178
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  178

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  179
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  179

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Arg Ala Ser 
            20                  25  


<210>  180
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  180

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  181
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  181

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser 
            20                  25  


<210>  182
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  182

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  183
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  183

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Pro Ser Cys Ala Ala Ser 
            20                  25  


<210>  184
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  184

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Thr Ser 
            20                  25  


<210>  185
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  185

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val His Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  186
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  186

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Ala Arg Leu Ser Cys Val Ala Ser 
            20                  25  


<210>  187
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  187

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  188
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  188

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  189
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  189

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  190
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  190

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Pro Cys Ala Ala Ser 
            20                  25  


<210>  191
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  191

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  192
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  192

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  193
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  193

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Trp Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  194
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  194

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Pro Ser Cys Ala Ala Ser 
            20                  25  


<210>  195
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  195

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  196
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  196

Glu Val Gln Leu Val Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ile Thr Ser 
            20                  25      


<210>  197
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  197

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser 
            20                  25  


<210>  198
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  198

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Met Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  199
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  199

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Leu Thr Ser 
            20                  25  


<210>  200
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  200

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Pro Arg Leu Ser Cys Val Ala Ser 
            20                  25  


<210>  201
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  201

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Pro Ser Cys Val Ala Ser 
            20                  25  


<210>  202
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  202

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Trp Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  203
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  203

Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala 
1               5                   10                  


<210>  204
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  204

Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Gly Leu Val Ala 
1               5                   10                  


<210>  205
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  205

Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Val Ala 
1               5                   10                  


<210>  206
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  206

Trp Tyr Arg Gln Thr Pro Glu Lys Glu Arg Glu Met Val Ala 
1               5                   10                  


<210>  207
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  207

Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val Ala 
1               5                   10                  


<210>  208
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  208

Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val Ala 
1               5                   10                  


<210>  209
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  209

Trp Tyr Arg Gln Cys Pro Gly Lys Glu Arg Glu Met Val Ala 
1               5                   10                  


<210>  210
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  210

Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala 
1               5                   10                  


<210>  211
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  211

Trp His Arg Gln Pro Pro Gly Lys Glu Arg Glu Lys Val Ala 
1               5                   10                  


<210>  212
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  212

Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val Ala 
1               5                   10                  


<210>  213
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  213

Trp His Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val Ala 
1               5                   10                  


<210>  214
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  214

Trp Tyr Arg Gln Ala Pro Glu Lys Glu Arg Glu Met Val Ala 
1               5                   10                  


<210>  215
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  215

Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Val Val Ala 
1               5                   10                  


<210>  216
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  216

Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Gly Val Val Ala 
1               5                   10                  


<210>  217
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  217

Trp Tyr Arg Gln Thr Pro Gly Lys Gln Arg Glu Leu Val Ala 
1               5                   10                  


<210>  218
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  218

Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Val Thr 
1               5                   10                  


<210>  219
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  219

Trp Tyr Arg Gln Ala Pro Gly His Glu Arg Glu Leu Val Ala 
1               5                   10                  


<210>  220
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  220

Trp Tyr Arg Gln Ala Pro Gly Asn Gln Arg Glu Val Val Ala 
1               5                   10                  


<210>  221
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  221

Trp Tyr Arg Gln Ala Pro Gly Asn Gln Arg Gly Val Val Ala 
1               5                   10                  


<210>  222
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  222

Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Gly Met Val Ala 
1               5                   10                  


<210>  223
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  223

Trp Tyr Arg Gln Ala Pro Ala Lys Glu His Glu Met Val Ala 
1               5                   10                  


<210>  224
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  224

Trp Tyr Arg Gln Ala Pro Ala Arg Glu Arg Glu Met Val Ala 
1               5                   10                  


<210>  225
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  225

Trp Tyr Arg Gln Gly Pro Gly Lys Gln Arg Glu Leu Val Ala 
1               5                   10                  


<210>  226
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  226

Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Gly Met Val Ala 
1               5                   10                  


<210>  227
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  227

Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Ile Ala 
1               5                   10                  


<210>  228
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  228

Trp Tyr Arg Gln Ala Pro Ala Lys Gly Arg Glu Met Val Ala 
1               5                   10                  


<210>  229
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  229

Trp Tyr Arg Gln Val Pro Ala Lys Glu Arg Glu Met Val Ala 
1               5                   10                  


<210>  230
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  230

Trp Tyr Arg Gln Cys Pro Gly Lys Glu Arg Asp Met Val Ala 
1               5                   10                  


<210>  231
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  231

Trp Gln Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val Ala 
1               5                   10                  


<210>  232
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  232

Trp Tyr Cys Gln Ala Pro Gly Lys Glu Arg Glu Met Val Ala 
1               5                   10                  


<210>  233
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  233

Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Asp Met Val Ala 
1               5                   10                  


<210>  234
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  234

Trp His Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val Ala 
1               5                   10                  


<210>  235
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  235

Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val His Phe Cys Arg Ala 
        35                  


<210>  236
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  236

Tyr Ala Asp Tyr Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Arg Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Arg Ala 
        35                  


<210>  237
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  237

Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Arg Ala 
        35                  


<210>  238
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  238

Tyr Ser His Phe Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Arg Ala 
        35                  


<210>  239
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  239

Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Thr Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Val Cys Arg Ala 
        35                  


<210>  240
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  240

Tyr Ala Glu Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Arg Ala 
        35                  


<210>  241
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  241

Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Ser Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Arg Ala 
        35                  


<210>  242
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  242

Tyr Ala His Phe Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Arg Ala 
        35                  


<210>  243
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  243

Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Glu Asp Ser Ala 
1               5                   10                  15      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Asn Ala 
        35                  


<210>  244
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  244

Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Thr Ser Leu Thr Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Val Cys Arg Ala 
        35                  


<210>  245
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  245

Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Arg Ala 
        35                  


<210>  246
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  246

Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Glu Asp Ser Ala 
1               5                   10                  15      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Asn Ala 
        35                  


<210>  247
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  247

Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Lys Asn Met Val His Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Arg Ala 
        35                  


<210>  248
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  248

Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Lys Asn Met Val Phe Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Arg Ala 
        35                  


<210>  249
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  249

Tyr Ala Gly Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Arg Ala 
        35                  


<210>  250
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  250

Tyr Ala Asp Phe Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Arg Ala 
        35                  


<210>  251
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  251

Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Thr Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Thr Val Tyr Val Cys Arg Ala 
        35                  


<210>  252
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  252

Tyr Ala Glu Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Leu Cys Arg Ala 
        35                  


<210>  253
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  253

Tyr Ala Asp Ser Ala Lys Gly Arg Phe Ala Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Arg Ala 
        35                  


<210>  254
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  254

Tyr Ala Asp Phe Ala Gln Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Arg Ala 
        35                  


<210>  255
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  255

Tyr Ala Glu Phe Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Pro 
1               5                   10                  15      


Lys Asn Met Val His Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Leu Cys Arg Ala 
        35                  


<210>  256
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  256

Tyr Ala Asp Phe Ala Lys Gly Arg Leu Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Arg Ala 
        35                  


<210>  257
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  257

Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Arg Ala 
        35                  


<210>  258
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  258

Tyr Ala Asp Phe Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Ala 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Arg Ala 
        35                  


<210>  259
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  259

Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Arg Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Leu Tyr Phe Cys His Ala 
        35                  


<210>  260
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  260

Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Ala Tyr Phe Cys Arg Ala 
        35                  


<210>  261
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  261

Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser 
1               5                   10                  15      


Arg Asn Met Val Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys His Ala 
        35                  


<210>  262
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  262

Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser 
1               5                   10                  15      


Arg Asn Met Val Tyr Leu Gln Met Gly Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys His Ala 
        35                  


<210>  263
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  263

Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Glu Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Arg Ala 
        35                  


<210>  264
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  264

Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Thr Asn Met Val Tyr Leu Gln Met Thr Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Arg Ala 
        35                  


<210>  265
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  265

Tyr Ala Gly Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Leu Asn Asn Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Arg Ala 
        35                  


<210>  266
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  266

Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Leu Asn Asn Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Arg Ala 
        35                  


<210>  267
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  267

Tyr Ala Glu Phe Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Pro 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Leu Cys Arg Ala 
        35                  


<210>  268
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  268

Tyr Ala His Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Thr Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Val Cys Arg Ala 
        35                  


<210>  269
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  269

Tyr Ala Asp Phe Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Val 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Arg Ala 
        35                  


<210>  270
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  270

Tyr Ala Asp Phe Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Arg Ala 
        35                  


<210>  271
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  271

Tyr Ser Tyr Phe Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Arg Ala 
        35                  


<210>  272
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  272

Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Lys Asn Val Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Arg Ala 
        35                  


<210>  273
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  273

Tyr Glu Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Thr Gly Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Val Cys Arg Ala 
        35                  


<210>  274
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  274

Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Glu Asp Ser Ala 
1               5                   10                  15      


Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Asn Ala 
        35                  


<210>  275
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  275

Tyr Ser His Phe Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Asn Gly Leu Arg Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Arg Ala 
        35                  


<210>  276
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  276

Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Leu Cys Arg Ala 
        35                  


<210>  277
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  277

Tyr Ala Glu Phe Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Pro 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Val Asp Thr 
            20                  25                  30          


Ala Val Tyr Leu Cys Arg Ala 
        35                  


<210>  278
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  278

Tyr Ser His Phe Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Asn Asn Leu Arg Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Arg Ala 
        35                  


<210>  279
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  279

Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Glu Asp Ser Ala 
1               5                   10                  15      


Lys Asp Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Asn Ala 
        35                  


<210>  280
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  280

Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ala 
            20                  25                  30          


Ala Val Tyr Phe Cys Arg Ala 
        35                  


<210>  281
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  281

Tyr Ala Glu Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ala 
            20                  25                  30          


Ala Val Tyr Leu Cys Arg Ala 
        35                  


<210>  282
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  282

Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser 
1               5                   10                  15      


Arg Asn Met Val Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asn Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys His Ala 
        35                  


<210>  283
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  283

Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Arg Ala 
        35                  


<210>  284
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  284

Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Gly Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Arg Ala 
        35                  


<210>  285
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4

<400>  285

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  286
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4

<400>  286

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  287
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4

<400>  287

Trp Gly Arg Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  288
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4

<400>  288

Trp Gly His Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  289
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4

<400>  289

Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  290
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4

<400>  290

Trp Asp Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  291
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  291

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Gly Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ala Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ser Ile Ser Trp Ser Gly Glu Asn Thr Asn Tyr Arg Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Lys Ile Ala Lys Thr Tyr Pro Asp Asn Trp Tyr Trp Thr Lys 
            100                 105                 110         


Ser Asn Asn Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
                165                 170                 175     


Gln Gly Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Arg Thr 
            180                 185                 190         


Phe Ser Ser Tyr Ala Met Ala Trp Phe Arg Gln Pro Pro Gly Lys Glu 
        195                 200                 205             


Arg Glu Phe Val Ala Ser Ile Ser Trp Ser Gly Glu Asn Thr Asn Tyr 
    210                 215                 220                 


Arg Asn Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
225                 230                 235                 240 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
                245                 250                 255     


Val Tyr Tyr Cys Ala Ala Lys Ile Ala Lys Thr Tyr Pro Asp Asn Trp 
            260                 265                 270         


Tyr Trp Thr Lys Ser Asn Asn Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
        275                 280                 285             


Val Thr Val Ser Ser Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp 
    290                 295                 300                 


Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala 
305                 310                 315                 320 


Ala His His His His His His 
                325         


<210>  292
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  292

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn Phe Leu Gly 
145                 150                 155                 160 


Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Gly Leu Val Ala Thr Ile 
                165                 170                 175     


Thr Ile Gly Asp Thr Thr Asp Tyr Ala Asp Tyr Ala Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Asp Glu Ala Arg Asn Met Val Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Gly Ser 
    210                 215                 220                 


Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp 
                245                 250                 255     


His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His 
            260                 265                 270         


His His His His 
        275     


<210>  293
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  293

Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Ile Gly Pro Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asn Met Gly Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Ser Thr Ile Tyr Ala Ser Tyr Tyr Glu Cys Gly His Gly 
            100                 105                 110         


Leu Ser Thr Gly Gly Tyr Gly Tyr Asp Ser Trp Gly Gln Gly Thr Gln 
        115                 120                 125             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
    130                 135                 140                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
145                 150                 155                 160 


Ala Ala Ser Gly Ser Val His Lys Ile Asn Phe Leu Gly Trp Tyr Arg 
                165                 170                 175     


Gln Ala Pro Gly Lys Glu Arg Gly Leu Val Ala Thr Ile Thr Ile Gly 
            180                 185                 190         


Asp Thr Thr Asp Tyr Ala Asp Tyr Ala Lys Gly Arg Phe Thr Ile Ser 
        195                 200                 205             


Arg Asp Glu Ala Arg Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys 
    210                 215                 220                 


Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Gly Ser Arg Leu Tyr 
225                 230                 235                 240 


Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                245                 250                 255     


Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile 
            260                 265                 270         


Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His His 
        275                 280                 285             


His 
    


<210>  294
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  294

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Val Gln 
        115                 120                 125             


Leu Gln Ala Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Tyr Thr Ile Gly Pro Tyr Cys Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala Ala Ile 
                165                 170                 175     


Asn Met Gly Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr Leu Leu Met 
        195                 200                 205             


Asn Ser Leu Glu Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala Asp 
    210                 215                 220                 


Ser Thr Ile Tyr Ala Ser Tyr Tyr Glu Cys Gly His Gly Leu Ser Thr 
225                 230                 235                 240 


Gly Gly Tyr Gly Tyr Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val 
                245                 250                 255     


Ser Ser Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp 
            260                 265                 270         


His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His 
        275                 280                 285             


His His His His 
    290         


<210>  295
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  295

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Gly Leu Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Thr Thr Asp Tyr Ala Asp Tyr Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Arg Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg 
145                 150                 155                 160 


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly 
                165                 170                 175     


Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser 
            180                 185                 190         


Glu Asp Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys 
        195                 200                 205             


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr 
    210                 215                 220                 


Met Thr Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp 
                245                 250                 255     


His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His 
            260                 265                 270         


His His His His 
        275     


<210>  296
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  296

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    130                 135                 140                 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Lys Ile 
145                 150                 155                 160 


Asn Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Gly Leu 
                165                 170                 175     


Val Ala Thr Ile Thr Ile Gly Asp Thr Thr Asp Tyr Ala Asp Tyr Ala 
            180                 185                 190         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Arg Asn Met Val Tyr 
        195                 200                 205             


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys 
    210                 215                 220                 


Arg Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser Gly Ala Ala Asp Tyr Lys Asp His Asp Gly 
                245                 250                 255     


Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
            260                 265                 270         


Ala Ala His His His His His His 
        275                 280 


<210>  297
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  297

Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Ile Gly Pro Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asn Met Gly Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Ser Thr Ile Tyr Ala Ser Tyr Tyr Glu Cys Gly His Gly 
            100                 105                 110         


Leu Ser Thr Gly Gly Tyr Gly Tyr Asp Ser Trp Gly Gln Gly Thr Gln 
        115                 120                 125             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
    130                 135                 140                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
145                 150                 155                 160 


Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn Phe Leu 
                165                 170                 175     


Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Gly Leu Val Ala Thr 
            180                 185                 190         


Ile Thr Ile Gly Asp Thr Thr Asp Tyr Ala Asp Tyr Ala Lys Gly Arg 
        195                 200                 205             


Phe Thr Ile Ser Arg Asp Glu Ala Arg Asn Met Val Tyr Leu Gln Met 
    210                 215                 220                 


Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Gly 
225                 230                 235                 240 


Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                245                 250                 255     


Val Ser Ser Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys 
            260                 265                 270         


Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His 
        275                 280                 285             


His His His His His 
    290             


<210>  298
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  298

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Ser Asp Val Gln Leu Gln Ala Ser Gly Gly Gly Ser Val Gln Ala Gly 
    130                 135                 140                 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Ile Gly Pro 
145                 150                 155                 160 


Tyr Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly 
                165                 170                 175     


Val Ala Ala Ile Asn Met Gly Gly Gly Ile Thr Tyr Tyr Ala Asp Ser 
            180                 185                 190         


Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val 
        195                 200                 205             


Tyr Leu Leu Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Ile Tyr Tyr 
    210                 215                 220                 


Cys Ala Ala Asp Ser Thr Ile Tyr Ala Ser Tyr Tyr Glu Cys Gly His 
225                 230                 235                 240 


Gly Leu Ser Thr Gly Gly Tyr Gly Tyr Asp Ser Trp Gly Gln Gly Thr 
                245                 250                 255     


Gln Val Thr Val Ser Ser Gly Ala Ala Asp Tyr Lys Asp His Asp Gly 
            260                 265                 270         


Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
        275                 280                 285             


Ala Ala His His His His His His 
    290                 295     


<210>  299
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  299

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Gly Leu Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Thr Thr Asp Tyr Ala Asp Tyr Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Arg Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met 
145                 150                 155                 160 


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Glu 
                165                 170                 175     


Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg 
            180                 185                 190         


Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val 
    210                 215                 220                 


Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser Gly Ala Ala Asp Tyr Lys Asp His Asp Gly 
                245                 250                 255     


Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
            260                 265                 270         


Ala Ala His His His His His His 
        275                 280 


<210>  300
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  300

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn Phe Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Glu Arg Gly Leu Val Ala Thr Ile Thr Ile 
        195                 200                 205             


Gly Asp Thr Thr Asp Tyr Ala Asp Tyr Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ala Arg Asn Met Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Gly Ser Arg Leu 
                245                 250                 255     


Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  301
<211>  319
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  301

Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Ile Gly Pro Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asn Met Gly Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Ser Thr Ile Tyr Ala Ser Tyr Tyr Glu Cys Gly His Gly 
            100                 105                 110         


Leu Ser Thr Gly Gly Tyr Gly Tyr Asp Ser Trp Gly Gln Gly Thr Gln 
        115                 120                 125             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
                165                 170                 175     


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
            180                 185                 190         


Ser Gly Ser Val His Lys Ile Asn Phe Leu Gly Trp Tyr Arg Gln Ala 
        195                 200                 205             


Pro Gly Lys Glu Arg Gly Leu Val Ala Thr Ile Thr Ile Gly Asp Thr 
    210                 215                 220                 


Thr Asp Tyr Ala Asp Tyr Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp 
225                 230                 235                 240 


Glu Ala Arg Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
                245                 250                 255     


Asp Thr Ala Val Tyr Phe Cys Arg Ala Gly Ser Arg Leu Tyr Pro Tyr 
            260                 265                 270         


Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ala Ala 
        275                 280                 285             


Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr 
    290                 295                 300                 


Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His His His 
305                 310                 315                 


<210>  302
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  302

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Leu Gln 
145                 150                 155                 160 


Ala Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Tyr Thr Ile Gly Pro Tyr Cys Met Gly Trp Phe 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala Ala Ile Asn Met 
        195                 200                 205             


Gly Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr Leu Leu Met Asn Ser 
225                 230                 235                 240 


Leu Glu Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala Asp Ser Thr 
                245                 250                 255     


Ile Tyr Ala Ser Tyr Tyr Glu Cys Gly His Gly Leu Ser Thr Gly Gly 
            260                 265                 270         


Tyr Gly Tyr Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        275                 280                 285             


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
    290                 295                 300                 


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
305                 310                 315                 320 


His His 
        


<210>  303
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  303

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Gly Leu Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Thr Thr Asp Tyr Ala Asp Tyr Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Arg Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  304
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  304

Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Ile Gly Pro Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asn Met Gly Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Ser Thr Ile Tyr Ala Ser Tyr Tyr Glu Cys Gly His Gly 
            100                 105                 110         


Leu Ser Thr Gly Gly Tyr Gly Tyr Asp Ser Trp Gly Gln Gly Thr Gln 
        115                 120                 125             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
                165                 170                 175     


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
            180                 185                 190         


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
        195                 200                 205             


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
    210                 215                 220                 


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
225                 230                 235                 240 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
                245                 250                 255     


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
            260                 265                 270         


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        275                 280                 285             


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
    290                 295                 300                 


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
305                 310                 315                 320 


His His 
        


<210>  305
<211>  319
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  305

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Gly Leu Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Thr Thr Asp Tyr Ala Asp Tyr Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Arg Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Leu Gln Ala Ser Gly 
145                 150                 155                 160 


Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                165                 170                 175     


Ser Gly Tyr Thr Ile Gly Pro Tyr Cys Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Gly Val Ala Ala Ile Asn Met Gly Gly Gly 
        195                 200                 205             


Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln 
    210                 215                 220                 


Asp Asn Ala Lys Asn Thr Val Tyr Leu Leu Met Asn Ser Leu Glu Pro 
225                 230                 235                 240 


Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala Asp Ser Thr Ile Tyr Ala 
                245                 250                 255     


Ser Tyr Tyr Glu Cys Gly His Gly Leu Ser Thr Gly Gly Tyr Gly Tyr 
            260                 265                 270         


Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ala Ala 
        275                 280                 285             


Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr 
    290                 295                 300                 


Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His His His 
305                 310                 315                 


<210>  306
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  306

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val Tyr Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp His Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  307
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  307

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Ala Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Thr Pro Glu Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Glu Val Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Val Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  308
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  308

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Thr Ser Gly Glu Thr Phe Lys Ile Asn 
            20                  25                  30          


Ile Trp Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Leu Thr Ile Gly Gly Ala Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Glu Asp Ser Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Asn 
                85                  90                  95      


Ala Lys Ser Arg Leu Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  309
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  309

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Leu Leu Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Ala Thr Asp Tyr Ala His Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  310
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  310

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Thr Ser Gly Glu Thr Phe Lys Ile Asn 
            20                  25                  30          


Ile Trp Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Leu Thr Ile Gly Gly Ala Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Glu Asp Ser Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys Asn 
                85                  90                  95      


Ala Lys Ser Arg Leu Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  311
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  311

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Glu Val Tyr Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Ala Ala Asp Tyr Ala Asp Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  312
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  312

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  313
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  313

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Glu Ile Gly Arg Ile Asn 
            20                  25                  30          


Phe Tyr Arg Trp Tyr Arg Gln Ala Pro Gly Asn Gln Arg Glu Val Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Ala Asp Lys Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Arg Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys His 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  314
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  314

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Gln Ala Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  315
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  315

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  316
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  316

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Thr Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  317
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  317

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Gly Leu Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Thr Thr Asp Tyr Ala Asp Tyr Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Arg Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  318
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  318

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Leu Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  319
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  319

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Val Ala Ser Gly Asp Val His Lys Ile Asn Phe Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val Ala His Ile Ser Ile 
        195                 200                 205             


Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Phe Ser Arg Ile 
                245                 250                 255     


Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  320
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  320

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Glu Ile Gly Arg Ile Asn Phe Tyr Arg Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Asn Gln Arg Glu Val Val Ala Thr Ile Thr Ile 
        195                 200                 205             


Ala Asp Lys Thr Asp Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ser Arg Asn Met Val Tyr Leu Gln Met Ser Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys His Ala Gly Ser Arg Leu 
                245                 250                 255     


Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  321
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  321

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Val Ala Ser Gly Asp Val His Lys Ile Asn Phe Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val Ala His Ile Thr Ile 
        195                 200                 205             


Gly Asp Gln Ala Asp Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Gly Ser Arg Ile 
                245                 250                 255     


Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  322
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  322

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn Ile Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val Ala His Ile Thr Ile 
        195                 200                 205             


Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Tyr Ser Arg Ile 
                245                 250                 255     


Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  323
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  323

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn Phe Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Thr Ile Thr Ile 
        195                 200                 205             


Gly Asp Thr Thr Asp Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Gly Ser Arg Leu 
                245                 250                 255     


Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  324
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  324

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn Phe Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Glu Arg Gly Leu Val Ala Thr Ile Thr Ile 
        195                 200                 205             


Gly Asp Thr Thr Asp Tyr Ala Asp Tyr Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ala Arg Asn Met Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Gly Ser Arg Leu 
                245                 250                 255     


Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  325
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  325

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Asp Val Tyr Lys Ile Asn Phe Leu Gly Trp His 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val Ala His Ile Thr Ile 
        195                 200                 205             


Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Gly Ser Arg Ile 
                245                 250                 255     


Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  326
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  326

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Glu Val Tyr Lys Ile Asn Phe Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val Ala His Ile Thr Ile 
        195                 200                 205             


Ala Asp Ala Ala Asp Tyr Ala Asp Phe Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Gly Ser Arg Ile 
                245                 250                 255     


Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  327
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  327

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn Phe Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Val Ala His Ile Thr Ile 
        195                 200                 205             


Ala Asp Ala Thr Asp Tyr Ala Glu Phe Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Pro Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Leu Cys Arg Ala Gly Ser Arg Ile 
                245                 250                 255     


Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  328
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  328

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ile Thr Ser Gly Glu Thr Phe Lys Ile Asn Ile Trp Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Ser Leu Thr Ile 
        195                 200                 205             


Gly Gly Ala Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Glu Asp Ser Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Asn Ala Lys Ser Arg Leu 
                245                 250                 255     


Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  329
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  329

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Ser Val His Leu Leu Asn Phe Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Val Ala His Ile Thr Ile 
        195                 200                 205             


Ala Asp Ala Thr Asp Tyr Ala His Phe Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Gly Ser Arg Ile 
                245                 250                 255     


Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  330
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  330

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ile Thr Ser Gly Glu Thr Phe Lys Ile Asn Ile Trp Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Ser Leu Thr Ile 
        195                 200                 205             


Gly Gly Ala Thr Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Glu Asp Ser Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys Asn Ala Lys Ser Arg Leu 
                245                 250                 255     


Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  331
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  331

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Ser Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  332
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  332

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  333
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  333

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn Ile Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val Ala His Ile Thr Ile 
        195                 200                 205             


Gly Asp Ala Thr Ser Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu Gln Leu Asn Asn Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Tyr Ser Arg Ile 
                245                 250                 255     


Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  334
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  334

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Val Ala Ser Gly Asp Val His Lys Ile Asn Phe Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val Ala His Ile Ser Ile 
        195                 200                 205             


Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Phe Ser Arg Ile 
                245                 250                 255     


Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  335
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  335

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Ala Thr Asp Tyr Ala Glu Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Pro Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Leu Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  336
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  336

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn Ile Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val Ala His Ile Thr Ile 
        195                 200                 205             


Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Leu Cys Arg Ala Tyr Ser Arg Ile 
                245                 250                 255     


Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  337
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  337

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Ala Val His Lys Ile Asn Phe Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Thr Pro Glu Lys Glu Arg Glu Met Val Ala Thr Ile Thr Ile 
        195                 200                 205             


Gly Asp Glu Val Asp Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu Gln Met Thr Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Val Cys Arg Ala Gly Ser Arg Leu 
                245                 250                 255     


Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        275                 280                 285             


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
    290                 295                 300                 


His His 
305     


<210>  338
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  338

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn Ile Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val Ala His Ile Thr Ile 
        195                 200                 205             


Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Tyr Ser Arg Ile 
                245                 250                 255     


Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Ala 
    


<210>  339
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  339

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Thr Ser Thr Asn Pro Gly Ser Tyr Ile Tyr Ile Trp 
            100                 105                 110         


Ala Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                165                 170                 175     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys 
            180                 185                 190         


Ile Asn Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu 
        195                 200                 205             


Met Val Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser 
    210                 215                 220                 


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val 
225                 230                 235                 240 


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe 
                245                 250                 255     


Cys Arg Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly 
            260                 265                 270         


Thr Leu Val Thr Val Ser Ser Ala 
        275                 280 


<210>  340
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  340

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Val Ala Ser Gly Asp Val His Lys Ile Asn Phe Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val Ala His Ile Ser Ile 
        195                 200                 205             


Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Phe Ser Arg Ile 
                245                 250                 255     


Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
305                 310                 315                 320 


Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                325                 330                 335     


Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            340                 345                 350         


Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala 
        355                 360                 365             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr 
    370                 375                 380                 


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
385                 390                 395                 400 


Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr 
                405                 410                 415     


Leu Val Thr Val Ser Ser Gly Ala Ala Asp Tyr Lys Asp His Asp Gly 
            420                 425                 430         


Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
        435                 440                 445             


Ala Ala His His His His His His 
    450                 455     


<210>  341
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  341

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ile Thr Ser Gly Glu Thr Phe Lys Ile Asn Ile Trp Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Ser Leu Thr Ile 
        195                 200                 205             


Gly Gly Ala Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Glu Asp Ser Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Asn Ala Lys Ser Arg Leu 
                245                 250                 255     


Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
305                 310                 315                 320 


Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                325                 330                 335     


Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            340                 345                 350         


Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala 
        355                 360                 365             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr 
    370                 375                 380                 


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
385                 390                 395                 400 


Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr 
                405                 410                 415     


Leu Val Thr Val Ser Ser Gly Ala Ala Asp Tyr Lys Asp His Asp Gly 
            420                 425                 430         


Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
        435                 440                 445             


Ala Ala His His His His His His 
    450                 455     


<210>  342
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  342

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser Ile Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Ser Ser Ile Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Lys 
                85                  90                  95      


Arg Phe Arg Thr Ala Ala Gln Gly Thr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
145                 150                 155                 160 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val 
                165                 170                 175     


Ala Ser Gly Asp Val His Lys Ile Asn Phe Leu Gly Trp Tyr Arg Gln 
            180                 185                 190         


Ala Pro Gly Lys Glu Arg Glu Lys Val Ala His Ile Ser Ile Gly Asp 
        195                 200                 205             


Gln Thr Asp Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg 
    210                 215                 220                 


Asp Glu Ser Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Phe Ser Arg Ile Tyr Pro 
                245                 250                 255     


Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ala 
            260                 265                 270         


Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
        275                 280                 285             


Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His His His 
    290                 295                 300                 


<210>  343
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  343

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                165                 170                 175     


Ser Gly Ile Thr Phe Ser Ile Asn Thr Met Gly Trp Tyr Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Gln Arg Glu Leu Val Ala Leu Ile Ser Ser Ile Gly Asp 
        195                 200                 205             


Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    210                 215                 220                 


Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Lys Arg Phe Arg Thr Ala Ala Gln Gly 
                245                 250                 255     


Thr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ala 
            260                 265                 270         


Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
        275                 280                 285             


Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His His His 
    290                 295                 300                 


<210>  344
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  344

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg 
    130                 135                 140                 


Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 
145                 150                 155                 160 


Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
                165                 170     


<210>  345
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  345

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Gln Leu Arg Arg Asn 
            180         


<210>  346
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  346

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


<210>  347
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  347

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  348
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  348

Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
1               5                   10                  15      


Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln 
            20                  25                  30          


Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys 
        35                  40                  45              


Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val 
    50                  55                  60                  


Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn 
65                  70                  75                  80  


Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys 
                85                  90                  95      


Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Phe Arg 
            100                 105                 110         


Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg 
        115                 120                 125             


Leu Trp Ser Ser Leu Asn Phe Gln Asn Leu Ser Val Ile Gly 
    130                 135                 140         


<210>  349
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  349

Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
1               5                   10                  15      


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
    50                  55                  60                  


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
65                  70                  75                  80  


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
                85                  90                  95      


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Val Ser 
            100                 105                 110         


Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr 
        115                 120                 125             


Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
    130                 135                 140                 


Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala 
145                 150                 155                 160 


Met Val Lys Arg Lys Asp Phe Gln Asp Arg Ala Lys Pro Val Thr Gln 
                165                 170                 175     


Ile 
    


<210>  350
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  350

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser Ile Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Ser Ser Ile Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Lys 
                85                  90                  95      


Arg Phe Arg Thr Ala Ala Gln Gly Thr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  351
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  351

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Gly Phe Asn 
            20                  25                  30          


Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Ser Arg Val Gly Val Thr Ser Ser Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Val Asn Ala Lys Asp Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      


Met Asp Gln Arg Leu Asp Gly Ser Thr Leu Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  352
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  352

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Val Ala Ile Asn Trp Ser Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Tyr Gln Ile Asn Ser Gly Asn Tyr Asn Phe Lys Asp Tyr 
            100                 105                 110         


Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  353
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  353

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Thr Tyr Gly Ser Tyr 
            20                  25                  30          


Trp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asn Arg Gly Gly Gly Tyr Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Asp Asp Thr Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Gly Val Leu Gly Gly Leu His Glu Asp Trp Phe Asn Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  354
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  354

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Thr Tyr Gly Ser Tyr 
            20                  25                  30          


Trp Met Gly Trp Phe Arg Gln Ala Pro Gly Gln Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Ala Ile Asn Arg Gly Gly Gly Tyr Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Asp Asp Thr Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Gly Val Leu Gly Gly Leu His Glu Asp Trp Phe Asn Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  355
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  355

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  356
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  356

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Ser Thr Ser Arg Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ala Gly Ser Thr Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  357
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  357

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  358
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  358

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Thr Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ala Trp Asp Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val His 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Tyr Asn Val Tyr Tyr Asn Asn Tyr Tyr Tyr Pro Ile Ser 
            100                 105                 110         


Arg Asp Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  359
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  359

Asp Val Gln Leu Gln Ala Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Ile Gly Pro Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asn Met Gly Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Ser Thr Ile Tyr Ala Ser Tyr Tyr Glu Cys Gly His Gly 
            100                 105                 110         


Leu Ser Thr Gly Gly Tyr Gly Tyr Asp Ser Trp Gly Gln Gly Thr Gln 
        115                 120                 125             


Val Thr Val Ser Ser 
    130             


<210>  360
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  360

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Thr Ser Thr Asn Pro Gly Ser Tyr Ile Tyr Ile Trp 
            100                 105                 110         


Ala Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  361
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  361

Gly Asp Thr Tyr Gly Ser Tyr Trp Met Gly 
1               5                   10  


<210>  362
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  362

Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly 
1               5                   10  


<210>  363
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  363

Ala Ile Asn Arg Gly Gly Gly Tyr Thr Val 
1               5                   10  


<210>  364
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  364

Glu Val Arg Trp Gly Gly Val Thr Thr 
1               5                   


<210>  365
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  365

Ser Gly Val Leu Gly Gly Leu His Glu Asp Trp Phe Asn Tyr 
1               5                   10                  


<210>  366
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  366

Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr 
1               5                   10          


<210>  367
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  367

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  368
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  368

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser 
            20                  25  


<210>  369
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  369

Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala 
1               5                   10                  


<210>  370
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  370

Trp Phe Arg Gln Ala Pro Gly Gln Glu Arg Glu Ala Val Ala 
1               5                   10                  


<210>  371
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  371

Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
1               5                   10                  


<210>  372
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  372

Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ala 
1               5                   10                  15      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Asp Asp Thr 
            20                  25                  30          


Ala Asp Tyr Tyr Cys Ala Ala 
        35                  


<210>  373
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  373

Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Asp Asp Thr 
            20                  25                  30          


Ala Asp Tyr Tyr Cys Ala Ala 
        35                  


<210>  374
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  374

Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp Ser Val 
1               5                   10                  15      


Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210>  375
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4

<400>  375

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  376
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  376

Gly Gly Gly Gly Ser 
1               5   


<210>  377
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  377

Ser Gly Gly Ser Gly Gly Ser 
1               5           


<210>  378
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  378

Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   


<210>  379
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  379

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  380
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  380

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  381
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  381

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  382
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  382

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  383
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  383

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  384
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  384

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210>  385
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  385

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser 
        35  


<210>  386
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  386

Ala Ala Ala 
1           


<210>  387
<211>  423
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  387

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn Ile Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val Ala His Ile Thr Ile 
        195                 200                 205             


Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Tyr Ser Arg Ile 
                245                 250                 255     


Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
305                 310                 315                 320 


Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                325                 330                 335     


Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            340                 345                 350         


Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala 
        355                 360                 365             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr 
    370                 375                 380                 


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
385                 390                 395                 400 


Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr 
                405                 410                 415     


Leu Val Thr Val Ser Ser Ala 
            420             


<210>  388
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  388

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Val Ala Ser Gly Asp Val His Lys Ile Asn Phe Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val Ala His Ile Ser Ile 
        195                 200                 205             


Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Phe Ser Arg Ile 
                245                 250                 255     


Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Ala 
    


<210>  389
<211>  430
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  389

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Thr Ser Thr Asn Pro Gly Ser Tyr Ile Tyr Ile Trp 
            100                 105                 110         


Ala Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                165                 170                 175     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys 
            180                 185                 190         


Ile Asn Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu 
        195                 200                 205             


Met Val Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser 
    210                 215                 220                 


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val 
225                 230                 235                 240 


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe 
                245                 250                 255     


Cys Arg Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly 
            260                 265                 270         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    290                 295                 300                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
305                 310                 315                 320 


Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys 
                325                 330                 335     


Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg 
            340                 345                 350         


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser 
        355                 360                 365             


Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    370                 375                 380                 


Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu 
385                 390                 395                 400 


Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu 
                405                 410                 415     


Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            420                 425                 430 


<210>  390
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  390

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Thr Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ala Trp Asp Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val His 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Tyr Asn Val Tyr Tyr Asn Asn Tyr Tyr Tyr Pro Ile Ser 
            100                 105                 110         


Arg Asp Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val 
                165                 170                 175     


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Thr 
            180                 185                 190         


Tyr Gly Ser Tyr Trp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
        195                 200                 205             


Arg Glu Gly Val Ala Ala Ile Asn Arg Gly Gly Gly Tyr Thr Val Tyr 
    210                 215                 220                 


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ala Lys 
225                 230                 235                 240 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Asp Asp Thr Ala 
                245                 250                 255     


Asp Tyr Tyr Cys Ala Ala Ser Gly Val Leu Gly Gly Leu His Glu Asp 
            260                 265                 270         


Trp Phe Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
305                 310                 315                 320 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                325                 330                 335     


Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys 
            340                 345                 350         


Ile Asn Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        355                 360                 365             


Lys Val Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser 
    370                 375                 380                 


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val 
385                 390                 395                 400 


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe 
                405                 410                 415     


Cys Arg Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly 
            420                 425                 430         


Thr Leu Val Thr Val Ser Ser Gly Ala Ala Asp Tyr Lys Asp His Asp 
        435                 440                 445             


Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
    450                 455                 460                 


Gly Ala Ala His His His His His His 
465                 470             


<210>  391
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  391

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Ile Gly Pro Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asn Met Gly Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Ser Thr Ile Tyr Ala Ser Tyr Tyr Glu Cys Gly His Gly 
            100                 105                 110         


Leu Ser Thr Gly Gly Tyr Gly Tyr Asp Ser Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
                165                 170                 175     


Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
            180                 185                 190         


Ser Gly Asp Thr Tyr Gly Ser Tyr Trp Met Gly Trp Phe Arg Gln Ala 
        195                 200                 205             


Pro Gly Lys Glu Arg Glu Gly Val Ala Ala Ile Asn Arg Gly Gly Gly 
    210                 215                 220                 


Tyr Thr Val Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
225                 230                 235                 240 


Asp Thr Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro 
                245                 250                 255     


Asp Asp Thr Ala Asp Tyr Tyr Cys Ala Ala Ser Gly Val Leu Gly Gly 
            260                 265                 270         


Leu His Glu Asp Trp Phe Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        275                 280                 285             


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
                325                 330                 335     


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly 
            340                 345                 350         


Asp Val His Lys Ile Asn Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly 
        355                 360                 365             


Lys Glu Arg Glu Lys Val Ala His Ile Ser Ile Gly Asp Gln Thr Asp 
    370                 375                 380                 


Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser 
385                 390                 395                 400 


Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
                405                 410                 415     


Ala Val Tyr Phe Cys Arg Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr 
            420                 425                 430         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ala Ala Asp Tyr 
        435                 440                 445             


Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp 
    450                 455                 460                 


Asp Asp Asp Lys Gly Ala Ala His His His His His His 
465                 470                 475         


<210>  392
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  392

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Thr Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ala Trp Asp Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val His 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Tyr Asn Val Tyr Tyr Asn Asn Tyr Tyr Tyr Pro Ile Ser 
            100                 105                 110         


Arg Asp Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val 
                165                 170                 175     


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr 
            180                 185                 190         


Ile Gly Pro Tyr Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
        195                 200                 205             


Arg Glu Gly Val Ala Ala Ile Asn Met Gly Gly Gly Ile Thr Tyr Tyr 
    210                 215                 220                 


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys 
225                 230                 235                 240 


Asn Thr Val Tyr Leu Leu Met Asn Ser Leu Glu Pro Glu Asp Thr Ala 
                245                 250                 255     


Ile Tyr Tyr Cys Ala Ala Asp Ser Thr Ile Tyr Ala Ser Tyr Tyr Glu 
            260                 265                 270         


Cys Gly His Gly Leu Ser Thr Gly Gly Tyr Gly Tyr Asp Ser Trp Gly 
        275                 280                 285             


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
305                 310                 315                 320 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
                325                 330                 335     


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
            340                 345                 350         


Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn Phe Leu Gly Trp 
        355                 360                 365             


Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val Ala His Ile Ser 
    370                 375                 380                 


Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr 
385                 390                 395                 400 


Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu Gln Met Asn Ser 
                405                 410                 415     


Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Phe Ser Arg 
            420                 425                 430         


Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        435                 440                 445             


Ser Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His 
    450                 455                 460                 


Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His 
465                 470                 475                 480 


His His His 
            


<210>  393
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  393

Ile Gln Val Glu Gln Ser Pro Pro Asp Leu Ile Leu Gln Glu Gly Ala 
1               5                   10                  15      


Asn Ser Thr Leu Arg Cys Asn Phe Ser Asp Ser Val Asn Asn Leu Gln 
            20                  25                  30          


Trp Phe His Gln Asn Pro Trp Gly Gln Leu Ile Asn Leu Phe Tyr Ile 
        35                  40                  45              


Pro Ser Gly Thr Lys Gln Asn Gly Arg Leu Ser Ala Thr Thr Val Ala 
    50                  55                  60                  


Thr Glu Arg Tyr Ser Leu Leu Tyr Ile Ser Ser Ser Gln Thr Thr Asp 
65                  70                  75                  80  


Ser Gly Val Tyr Phe Cys Ala Ala Leu Ile Gln Gly Ala Gln Lys Leu 
                85                  90                  95      


Val Phe Gly Gln Gly Thr Arg Leu Thr Ile Asn 
            100                 105         


<210>  394
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  394

Gln Leu Leu Glu Gln Ser Pro Gln Phe Leu Ser Ile Gln Glu Gly Glu 
1               5                   10                  15      


Asn Leu Thr Val Tyr Cys Asn Ser Ser Ser Val Phe Ser Ser Leu Gln 
            20                  25                  30          


Trp Tyr Arg Gln Glu Pro Gly Glu Gly Pro Val Leu Leu Val Thr Val 
        35                  40                  45              


Val Thr Gly Gly Glu Val Lys Lys Leu Lys Arg Leu Thr Phe Gln Phe 
    50                  55                  60                  


Gly Asp Ala Arg Lys Asp Ser Ser Leu His Ile Thr Ala Ala Gln Pro 
65                  70                  75                  80  


Gly Asp Thr Gly Leu Tyr Leu Cys Ala Gly Ala Gly Ser Gln Gly Asn 
                85                  90                  95      


Leu Ile Phe Gly Lys Gly Thr Lys Leu Ser Val Lys 
            100                 105             


<210>  395
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  395

Gly Asp Ala Lys Thr Thr Gln Pro Asn Ser Met Glu Ser Asn Glu Glu 
1               5                   10                  15      


Glu Pro Val His Leu Pro Cys Asn His Ser Thr Ile Ser Gly Thr Asp 
            20                  25                  30          


Tyr Ile His Trp Tyr Arg Gln Leu Pro Ser Gln Gly Pro Glu Tyr Val 
        35                  40                  45              


Ile His Gly Leu Thr Ser Asn Val Asn Asn Arg Met Ala Ser Leu Ala 
    50                  55                  60                  


Ile Ala Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu His Arg Ala Thr 
65                  70                  75                  80  


Leu Arg Asp Ala Ala Val Tyr Tyr Cys Thr Val Tyr Gly Gly Ala Thr 
                85                  90                  95      


Asn Lys Leu Ile Phe Gly Thr Gly Thr Leu Leu Ala Val Gln 
            100                 105                 110 


<210>  396
<211>  96
<212>  PRT
<213>  Macaca fascicularis

<400>  396

Pro Tyr Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Gly Ser 
1               5                   10                  15      


Lys Ser Asn Asp Thr Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Val 
            20                  25                  30          


Met Asn Val Ser Gln Ser Lys Asp Ser Asp Val His Ile Thr Asp Lys 
        35                  40                  45              


Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Gly Ala Val 
    50                  55                  60                  


Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Thr Ser Ala Phe Lys Asp 
65                  70                  75                  80  


Ser Val Ile Pro Ala Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys 
                85                  90                  95      


<210>  397
<211>  131
<212>  PRT
<213>  Macaca mulatta

<400>  397

Glu Asp Leu Lys Lys Val Phe Pro Pro Lys Val Ala Val Phe Glu Pro 
1               5                   10                  15      


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
    50                  55                  60                  


Glu Gln Pro Ala Leu Glu Asp Ser Arg Tyr Ser Leu Ser Ser Arg Leu 
65                  70                  75                  80  


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
                85                  90                  95      


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asp Asp Glu Trp Thr Glu Asp 
            100                 105                 110         


Arg Asp Lys Pro Ile Thr Gln Lys Ile Ser Ala Glu Ala Trp Gly Arg 
        115                 120                 125             


Ala Asp Cys 
    130     


<210>  398
<211>  107
<212>  PRT
<213>  Macaca mulatta

<400>  398

Gln Gln Ile Met Gln Ile Pro Gln Tyr Gln His Val Gln Glu Gly Glu 
1               5                   10                  15      


Asp Phe Thr Thr Tyr Cys Asn Ser Ser Thr Thr Leu Ser Asn Ile Gln 
            20                  25                  30          


Trp Tyr Lys Gln Arg Pro Gly Gly His Pro Val Phe Leu Ile Met Leu 
        35                  40                  45              


Val Lys Ser Gly Glu Val Lys Lys Gln Lys Arg Leu Ile Phe Gln Phe 
    50                  55                  60                  


Gly Glu Ala Lys Lys Asn Ser Ser Leu His Ile Thr Ala Thr Gln Thr 
65                  70                  75                  80  


Thr Asp Val Gly Thr Tyr Phe Cys Ala Thr Thr Gly Val Asn Asn Leu 
                85                  90                  95      


Phe Phe Gly Thr Gly Thr Arg Leu Thr Val Leu 
            100                 105         


<210>  399
<211>  118
<212>  PRT
<213>  Macaca mulatta

<400>  399

Ala Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val 
1               5                   10                  15      


Leu Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn 
            20                  25                  30          


His Asp Tyr Met Tyr Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg 
        35                  40                  45              


Leu Ile His Tyr Ser Val Gly Glu Gly Ser Thr Glu Lys Gly Glu Val 
    50                  55                  60                  


Pro Asp Gly Tyr Asn Val Thr Arg Ser Asn Thr Glu Asp Phe Pro Leu 
65                  70                  75                  80  


Arg Leu Glu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala 
                85                  90                  95      


Ser Ser Tyr Trp Thr Gly Arg Ser Tyr Glu Gln Tyr Phe Gly Pro Gly 
            100                 105                 110         


Thr Arg Leu Thr Val Ile 
        115             


<210>  400
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  400

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  401
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  401

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  402
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  402

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala 
        115     


<210>  403
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  403

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala 
        115     


<210>  404
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  404

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  405
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  405

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Lys 
            100                 105                 110         


Val Ser Ser Ala 
        115     


<210>  406
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  406

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  407
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  407

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala 
        115     


<210>  408
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  408

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ala 
        115         


<210>  409
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  409

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ala Ala 
        115             


<210>  410
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  410

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly 
        115     


<210>  411
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  411

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly 
        115         


<210>  412
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  412

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly 
        115             


<210>  413
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  413

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Gly Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ala Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ser Ile Ser Trp Ser Gly Glu Asn Thr Asn Tyr Arg Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Lys Ile Ala Lys Thr Tyr Pro Asp Asn Trp Tyr Trp Thr Lys 
            100                 105                 110         


Ser Asn Asn Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
                165                 170                 175     


Gln Gly Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Arg Thr 
            180                 185                 190         


Phe Ser Ser Tyr Ala Met Ala Trp Phe Arg Gln Pro Pro Gly Lys Glu 
        195                 200                 205             


Arg Glu Phe Val Ala Ser Ile Ser Trp Ser Gly Glu Asn Thr Asn Tyr 
    210                 215                 220                 


Arg Asn Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
225                 230                 235                 240 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
                245                 250                 255     


Val Tyr Tyr Cys Ala Ala Lys Ile Ala Lys Thr Tyr Pro Asp Asn Trp 
            260                 265                 270         


Tyr Trp Thr Lys Ser Asn Asn Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
        275                 280                 285             


Val Thr Val Ser Ser 
    290             


<210>  414
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  414

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn Phe Leu Gly 
145                 150                 155                 160 


Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Gly Leu Val Ala Thr Ile 
                165                 170                 175     


Thr Ile Gly Asp Thr Thr Asp Tyr Ala Asp Tyr Ala Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Asp Glu Ala Arg Asn Met Val Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Gly Ser 
    210                 215                 220                 


Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  415
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  415

Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Ile Gly Pro Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asn Met Gly Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Ser Thr Ile Tyr Ala Ser Tyr Tyr Glu Cys Gly His Gly 
            100                 105                 110         


Leu Ser Thr Gly Gly Tyr Gly Tyr Asp Ser Trp Gly Gln Gly Thr Gln 
        115                 120                 125             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
    130                 135                 140                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
145                 150                 155                 160 


Ala Ala Ser Gly Ser Val His Lys Ile Asn Phe Leu Gly Trp Tyr Arg 
                165                 170                 175     


Gln Ala Pro Gly Lys Glu Arg Gly Leu Val Ala Thr Ile Thr Ile Gly 
            180                 185                 190         


Asp Thr Thr Asp Tyr Ala Asp Tyr Ala Lys Gly Arg Phe Thr Ile Ser 
        195                 200                 205             


Arg Asp Glu Ala Arg Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys 
    210                 215                 220                 


Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Gly Ser Arg Leu Tyr 
225                 230                 235                 240 


Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 255 


<210>  416
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  416

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Val Gln 
        115                 120                 125             


Leu Gln Ala Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Tyr Thr Ile Gly Pro Tyr Cys Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala Ala Ile 
                165                 170                 175     


Asn Met Gly Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr Leu Leu Met 
        195                 200                 205             


Asn Ser Leu Glu Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala Asp 
    210                 215                 220                 


Ser Thr Ile Tyr Ala Ser Tyr Tyr Glu Cys Gly His Gly Leu Ser Thr 
225                 230                 235                 240 


Gly Gly Tyr Gly Tyr Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val 
                245                 250                 255     


Ser Ser 
        


<210>  417
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  417

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Gly Leu Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Thr Thr Asp Tyr Ala Asp Tyr Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Arg Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg 
145                 150                 155                 160 


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly 
                165                 170                 175     


Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser 
            180                 185                 190         


Glu Asp Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys 
        195                 200                 205             


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr 
    210                 215                 220                 


Met Thr Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  418
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  418

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    130                 135                 140                 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Lys Ile 
145                 150                 155                 160 


Asn Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Gly Leu 
                165                 170                 175     


Val Ala Thr Ile Thr Ile Gly Asp Thr Thr Asp Tyr Ala Asp Tyr Ala 
            180                 185                 190         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Arg Asn Met Val Tyr 
        195                 200                 205             


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys 
    210                 215                 220                 


Arg Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser 
                245     


<210>  419
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  419

Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Ile Gly Pro Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asn Met Gly Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Ser Thr Ile Tyr Ala Ser Tyr Tyr Glu Cys Gly His Gly 
            100                 105                 110         


Leu Ser Thr Gly Gly Tyr Gly Tyr Asp Ser Trp Gly Gln Gly Thr Gln 
        115                 120                 125             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
    130                 135                 140                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
145                 150                 155                 160 


Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn Phe Leu 
                165                 170                 175     


Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Gly Leu Val Ala Thr 
            180                 185                 190         


Ile Thr Ile Gly Asp Thr Thr Asp Tyr Ala Asp Tyr Ala Lys Gly Arg 
        195                 200                 205             


Phe Thr Ile Ser Arg Asp Glu Ala Arg Asn Met Val Tyr Leu Gln Met 
    210                 215                 220                 


Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Gly 
225                 230                 235                 240 


Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                245                 250                 255     


Val Ser Ser 
            


<210>  420
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  420

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Ser Asp Val Gln Leu Gln Ala Ser Gly Gly Gly Ser Val Gln Ala Gly 
    130                 135                 140                 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Ile Gly Pro 
145                 150                 155                 160 


Tyr Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly 
                165                 170                 175     


Val Ala Ala Ile Asn Met Gly Gly Gly Ile Thr Tyr Tyr Ala Asp Ser 
            180                 185                 190         


Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val 
        195                 200                 205             


Tyr Leu Leu Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Ile Tyr Tyr 
    210                 215                 220                 


Cys Ala Ala Asp Ser Thr Ile Tyr Ala Ser Tyr Tyr Glu Cys Gly His 
225                 230                 235                 240 


Gly Leu Ser Thr Gly Gly Tyr Gly Tyr Asp Ser Trp Gly Gln Gly Thr 
                245                 250                 255     


Gln Val Thr Val Ser Ser 
            260         


<210>  421
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  421

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Gly Leu Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Thr Thr Asp Tyr Ala Asp Tyr Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Arg Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met 
145                 150                 155                 160 


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Glu 
                165                 170                 175     


Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg 
            180                 185                 190         


Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val 
    210                 215                 220                 


Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser 
                245     


<210>  422
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  422

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn Phe Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Glu Arg Gly Leu Val Ala Thr Ile Thr Ile 
        195                 200                 205             


Gly Asp Thr Thr Asp Tyr Ala Asp Tyr Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ala Arg Asn Met Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Gly Ser Arg Leu 
                245                 250                 255     


Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  423
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  423

Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Ile Gly Pro Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asn Met Gly Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Ser Thr Ile Tyr Ala Ser Tyr Tyr Glu Cys Gly His Gly 
            100                 105                 110         


Leu Ser Thr Gly Gly Tyr Gly Tyr Asp Ser Trp Gly Gln Gly Thr Gln 
        115                 120                 125             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
                165                 170                 175     


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
            180                 185                 190         


Ser Gly Ser Val His Lys Ile Asn Phe Leu Gly Trp Tyr Arg Gln Ala 
        195                 200                 205             


Pro Gly Lys Glu Arg Gly Leu Val Ala Thr Ile Thr Ile Gly Asp Thr 
    210                 215                 220                 


Thr Asp Tyr Ala Asp Tyr Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp 
225                 230                 235                 240 


Glu Ala Arg Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
                245                 250                 255     


Asp Thr Ala Val Tyr Phe Cys Arg Ala Gly Ser Arg Leu Tyr Pro Tyr 
            260                 265                 270         


Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        275                 280                 285 


<210>  424
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  424

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Leu Gln 
145                 150                 155                 160 


Ala Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Tyr Thr Ile Gly Pro Tyr Cys Met Gly Trp Phe 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala Ala Ile Asn Met 
        195                 200                 205             


Gly Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr Leu Leu Met Asn Ser 
225                 230                 235                 240 


Leu Glu Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala Asp Ser Thr 
                245                 250                 255     


Ile Tyr Ala Ser Tyr Tyr Glu Cys Gly His Gly Leu Ser Thr Gly Gly 
            260                 265                 270         


Tyr Gly Tyr Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        275                 280                 285             


<210>  425
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  425

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Gly Leu Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Thr Thr Asp Tyr Ala Asp Tyr Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Arg Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  426
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  426

Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Ile Gly Pro Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asn Met Gly Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Ser Thr Ile Tyr Ala Ser Tyr Tyr Glu Cys Gly His Gly 
            100                 105                 110         


Leu Ser Thr Gly Gly Tyr Gly Tyr Asp Ser Trp Gly Gln Gly Thr Gln 
        115                 120                 125             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
                165                 170                 175     


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
            180                 185                 190         


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
        195                 200                 205             


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
    210                 215                 220                 


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
225                 230                 235                 240 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
                245                 250                 255     


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
            260                 265                 270         


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        275                 280                 285             


<210>  427
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  427

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Gly Leu Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Thr Thr Asp Tyr Ala Asp Tyr Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Arg Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Leu Gln Ala Ser Gly 
145                 150                 155                 160 


Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                165                 170                 175     


Ser Gly Tyr Thr Ile Gly Pro Tyr Cys Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Gly Val Ala Ala Ile Asn Met Gly Gly Gly 
        195                 200                 205             


Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln 
    210                 215                 220                 


Asp Asn Ala Lys Asn Thr Val Tyr Leu Leu Met Asn Ser Leu Glu Pro 
225                 230                 235                 240 


Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala Asp Ser Thr Ile Tyr Ala 
                245                 250                 255     


Ser Tyr Tyr Glu Cys Gly His Gly Leu Ser Thr Gly Gly Tyr Gly Tyr 
            260                 265                 270         


Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        275                 280                 285 


<210>  428
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  428

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val Tyr Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp His Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  429
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  429

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Ala Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Thr Pro Glu Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Glu Val Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Val Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  430
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  430

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Thr Ser Gly Glu Thr Phe Lys Ile Asn 
            20                  25                  30          


Ile Trp Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Leu Thr Ile Gly Gly Ala Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Glu Asp Ser Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Asn 
                85                  90                  95      


Ala Lys Ser Arg Leu Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  431
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  431

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Leu Leu Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Ala Thr Asp Tyr Ala His Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  432
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  432

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Thr Ser Gly Glu Thr Phe Lys Ile Asn 
            20                  25                  30          


Ile Trp Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Leu Thr Ile Gly Gly Ala Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Glu Asp Ser Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys Asn 
                85                  90                  95      


Ala Lys Ser Arg Leu Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  433
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  433

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Glu Val Tyr Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Ala Ala Asp Tyr Ala Asp Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  434
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  434

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  435
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  435

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Glu Ile Gly Arg Ile Asn 
            20                  25                  30          


Phe Tyr Arg Trp Tyr Arg Gln Ala Pro Gly Asn Gln Arg Glu Val Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Ala Asp Lys Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Arg Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys His 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  436
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  436

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Gln Ala Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  437
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  437

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  438
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  438

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Thr Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  439
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  439

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Gly Leu Val 
        35                  40                  45              


Ala Thr Ile Thr Ile Gly Asp Thr Thr Asp Tyr Ala Asp Tyr Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Arg Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Leu Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  440
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  440

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Leu Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  441
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  441

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Val Ala Ser Gly Asp Val His Lys Ile Asn Phe Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val Ala His Ile Ser Ile 
        195                 200                 205             


Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Phe Ser Arg Ile 
                245                 250                 255     


Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  442
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  442

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Glu Ile Gly Arg Ile Asn Phe Tyr Arg Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Asn Gln Arg Glu Val Val Ala Thr Ile Thr Ile 
        195                 200                 205             


Ala Asp Lys Thr Asp Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ser Arg Asn Met Val Tyr Leu Gln Met Ser Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys His Ala Gly Ser Arg Leu 
                245                 250                 255     


Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  443
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  443

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Val Ala Ser Gly Asp Val His Lys Ile Asn Phe Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val Ala His Ile Thr Ile 
        195                 200                 205             


Gly Asp Gln Ala Asp Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Gly Ser Arg Ile 
                245                 250                 255     


Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  444
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  444

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn Ile Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val Ala His Ile Thr Ile 
        195                 200                 205             


Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Tyr Ser Arg Ile 
                245                 250                 255     


Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  445
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  445

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn Phe Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Thr Ile Thr Ile 
        195                 200                 205             


Gly Asp Thr Thr Asp Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Gly Ser Arg Leu 
                245                 250                 255     


Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  446
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  446

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Ser Val His Lys Ile Asn Phe Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Glu Arg Gly Leu Val Ala Thr Ile Thr Ile 
        195                 200                 205             


Gly Asp Thr Thr Asp Tyr Ala Asp Tyr Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ala Arg Asn Met Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Gly Ser Arg Leu 
                245                 250                 255     


Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  447
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  447

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Asp Val Tyr Lys Ile Asn Phe Leu Gly Trp His 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val Ala His Ile Thr Ile 
        195                 200                 205             


Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Gly Ser Arg Ile 
                245                 250                 255     


Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  448
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  448

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Glu Val Tyr Lys Ile Asn Phe Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val Ala His Ile Thr Ile 
        195                 200                 205             


Ala Asp Ala Ala Asp Tyr Ala Asp Phe Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Gly Ser Arg Ile 
                245                 250                 255     


Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  449
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  449

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn Phe Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Val Ala His Ile Thr Ile 
        195                 200                 205             


Ala Asp Ala Thr Asp Tyr Ala Glu Phe Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Pro Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Leu Cys Arg Ala Gly Ser Arg Ile 
                245                 250                 255     


Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  450
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  450

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ile Thr Ser Gly Glu Thr Phe Lys Ile Asn Ile Trp Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Ser Leu Thr Ile 
        195                 200                 205             


Gly Gly Ala Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Glu Asp Ser Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Asn Ala Lys Ser Arg Leu 
                245                 250                 255     


Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  451
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  451

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Ser Val His Leu Leu Asn Phe Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Val Ala His Ile Thr Ile 
        195                 200                 205             


Ala Asp Ala Thr Asp Tyr Ala His Phe Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Gly Ser Arg Ile 
                245                 250                 255     


Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  452
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  452

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ile Thr Ser Gly Glu Thr Phe Lys Ile Asn Ile Trp Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Ser Leu Thr Ile 
        195                 200                 205             


Gly Gly Ala Thr Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Glu Asp Ser Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys Asn Ala Lys Ser Arg Leu 
                245                 250                 255     


Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  453
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  453

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Gly Asp Ala Thr Ser Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  454
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  454

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  455
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  455

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn Ile Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val Ala His Ile Thr Ile 
        195                 200                 205             


Gly Asp Ala Thr Ser Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu Gln Leu Asn Asn Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Tyr Ser Arg Ile 
                245                 250                 255     


Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  456
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  456

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Val Ala Ser Gly Asp Val His Lys Ile Asn Phe Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val Ala His Ile Ser Ile 
        195                 200                 205             


Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Phe Ser Arg Ile 
                245                 250                 255     


Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  457
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  457

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala His Ile Thr Ile Ala Asp Ala Thr Asp Tyr Ala Glu Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Pro Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Leu Cys Arg 
                85                  90                  95      


Ala Gly Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Phe 
                165                 170                 175     


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Glu Val Arg Trp Gly Gly Val 
        195                 200                 205             


Thr Thr Tyr Ser Asn Ser Leu Lys Asp Arg Phe Ser Ile Ser Glu Asp 
    210                 215                 220                 


Ser Val Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Val Arg Gln Met Tyr Met Thr 
                245                 250                 255     


Val Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  458
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  458

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn Ile Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val Ala His Ile Thr Ile 
        195                 200                 205             


Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Leu Cys Arg Ala Tyr Ser Arg Ile 
                245                 250                 255     


Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  459
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  459

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Ala Val His Lys Ile Asn Phe Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Thr Pro Glu Lys Glu Arg Glu Met Val Ala Thr Ile Thr Ile 
        195                 200                 205             


Gly Asp Glu Val Asp Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu Gln Met Thr Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Val Cys Arg Ala Gly Ser Arg Leu 
                245                 250                 255     


Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  460
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  460

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Val Ala Ser Gly Asp Val His Lys Ile Asn Phe Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val Ala His Ile Ser Ile 
        195                 200                 205             


Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Phe Ser Arg Ile 
                245                 250                 255     


Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
305                 310                 315                 320 


Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                325                 330                 335     


Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            340                 345                 350         


Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala 
        355                 360                 365             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr 
    370                 375                 380                 


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
385                 390                 395                 400 


Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr 
                405                 410                 415     


Leu Val Thr Val Ser Ser 
            420         


<210>  461
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  461

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ile Thr Ser Gly Glu Thr Phe Lys Ile Asn Ile Trp Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Ser Leu Thr Ile 
        195                 200                 205             


Gly Gly Ala Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Glu Asp Ser Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Asn Ala Lys Ser Arg Leu 
                245                 250                 255     


Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
305                 310                 315                 320 


Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                325                 330                 335     


Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            340                 345                 350         


Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala 
        355                 360                 365             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr 
    370                 375                 380                 


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
385                 390                 395                 400 


Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr 
                405                 410                 415     


Leu Val Thr Val Ser Ser 
            420         


<210>  462
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  462

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser Ile Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Ser Ser Ile Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Lys 
                85                  90                  95      


Arg Phe Arg Thr Ala Ala Gln Gly Thr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
145                 150                 155                 160 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val 
                165                 170                 175     


Ala Ser Gly Asp Val His Lys Ile Asn Phe Leu Gly Trp Tyr Arg Gln 
            180                 185                 190         


Ala Pro Gly Lys Glu Arg Glu Lys Val Ala His Ile Ser Ile Gly Asp 
        195                 200                 205             


Gln Thr Asp Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg 
    210                 215                 220                 


Asp Glu Ser Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Phe Ser Arg Ile Tyr Pro 
                245                 250                 255     


Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270 


<210>  463
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  463

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn 
            20                  25                  30          


Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val 
        35                  40                  45              


Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg 
                85                  90                  95      


Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                165                 170                 175     


Ser Gly Ile Thr Phe Ser Ile Asn Thr Met Gly Trp Tyr Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Gln Arg Glu Leu Val Ala Leu Ile Ser Ser Ile Gly Asp 
        195                 200                 205             


Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    210                 215                 220                 


Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Lys Arg Phe Arg Thr Ala Ala Gln Gly 
                245                 250                 255     


Thr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270 


<210>  464
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  464

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Thr Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ala Trp Asp Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val His 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Tyr Asn Val Tyr Tyr Asn Asn Tyr Tyr Tyr Pro Ile Ser 
            100                 105                 110         


Arg Asp Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val 
                165                 170                 175     


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Thr 
            180                 185                 190         


Tyr Gly Ser Tyr Trp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
        195                 200                 205             


Arg Glu Gly Val Ala Ala Ile Asn Arg Gly Gly Gly Tyr Thr Val Tyr 
    210                 215                 220                 


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ala Lys 
225                 230                 235                 240 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Asp Asp Thr Ala 
                245                 250                 255     


Asp Tyr Tyr Cys Ala Ala Ser Gly Val Leu Gly Gly Leu His Glu Asp 
            260                 265                 270         


Trp Phe Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
305                 310                 315                 320 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                325                 330                 335     


Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys 
            340                 345                 350         


Ile Asn Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        355                 360                 365             


Lys Val Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser 
    370                 375                 380                 


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val 
385                 390                 395                 400 


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe 
                405                 410                 415     


Cys Arg Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly 
            420                 425                 430         


Thr Leu Val Thr Val Ser Ser 
        435                 


<210>  465
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  465

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Ile Gly Pro Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asn Met Gly Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Ser Thr Ile Tyr Ala Ser Tyr Tyr Glu Cys Gly His Gly 
            100                 105                 110         


Leu Ser Thr Gly Gly Tyr Gly Tyr Asp Ser Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
                165                 170                 175     


Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
            180                 185                 190         


Ser Gly Asp Thr Tyr Gly Ser Tyr Trp Met Gly Trp Phe Arg Gln Ala 
        195                 200                 205             


Pro Gly Lys Glu Arg Glu Gly Val Ala Ala Ile Asn Arg Gly Gly Gly 
    210                 215                 220                 


Tyr Thr Val Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
225                 230                 235                 240 


Asp Thr Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro 
                245                 250                 255     


Asp Asp Thr Ala Asp Tyr Tyr Cys Ala Ala Ser Gly Val Leu Gly Gly 
            260                 265                 270         


Leu His Glu Asp Trp Phe Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        275                 280                 285             


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
                325                 330                 335     


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly 
            340                 345                 350         


Asp Val His Lys Ile Asn Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly 
        355                 360                 365             


Lys Glu Arg Glu Lys Val Ala His Ile Ser Ile Gly Asp Gln Thr Asp 
    370                 375                 380                 


Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser 
385                 390                 395                 400 


Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
                405                 410                 415     


Ala Val Tyr Phe Cys Arg Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr 
            420                 425                 430         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        435                 440             


<210>  466
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  466

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Thr Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ala Trp Asp Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val His 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Tyr Asn Val Tyr Tyr Asn Asn Tyr Tyr Tyr Pro Ile Ser 
            100                 105                 110         


Arg Asp Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val 
                165                 170                 175     


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr 
            180                 185                 190         


Ile Gly Pro Tyr Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
        195                 200                 205             


Arg Glu Gly Val Ala Ala Ile Asn Met Gly Gly Gly Ile Thr Tyr Tyr 
    210                 215                 220                 


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys 
225                 230                 235                 240 


Asn Thr Val Tyr Leu Leu Met Asn Ser Leu Glu Pro Glu Asp Thr Ala 
                245                 250                 255     


Ile Tyr Tyr Cys Ala Ala Asp Ser Thr Ile Tyr Ala Ser Tyr Tyr Glu 
            260                 265                 270         


Cys Gly His Gly Leu Ser Thr Gly Gly Tyr Gly Tyr Asp Ser Trp Gly 
        275                 280                 285             


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
305                 310                 315                 320 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
                325                 330                 335     


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
            340                 345                 350         


Ser Cys Val Ala Ser Gly Asp Val His Lys Ile Asn Phe Leu Gly Trp 
        355                 360                 365             


Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val Ala His Ile Ser 
    370                 375                 380                 


Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr 
385                 390                 395                 400 


Ile Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu Gln Met Asn Ser 
                405                 410                 415     


Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Phe Ser Arg 
            420                 425                 430         


Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        435                 440                 445             


Ser 
    


<210>  467
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  467

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn Ile Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val Ala His Ile Thr Ile 
        195                 200                 205             


Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Tyr Ser Arg Ile 
                245                 250                 255     


Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
305                 310                 315                 320 


Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                325                 330                 335     


Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            340                 345                 350         


Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala 
        355                 360                 365             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr 
    370                 375                 380                 


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
385                 390                 395                 400 


Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr 
                405                 410                 415     


Leu Val Thr Val Ser Ser 
            420         


<210>  468
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  468

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Val Ala Ser Gly Asp Val His Lys Ile Asn Phe Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Lys Val Ala His Ile Ser Ile 
        195                 200                 205             


Gly Asp Gln Thr Asp Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ser Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Phe Ser Arg Ile 
                245                 250                 255     


Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  469
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  469

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Thr Ser Thr Asn Pro Gly Ser Tyr Ile Tyr Ile Trp 
            100                 105                 110         


Ala Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                165                 170                 175     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys 
            180                 185                 190         


Ile Asn Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu 
        195                 200                 205             


Met Val Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser 
    210                 215                 220                 


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val 
225                 230                 235                 240 


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe 
                245                 250                 255     


Cys Arg Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly 
            260                 265                 270         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    290                 295                 300                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
305                 310                 315                 320 


Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys 
                325                 330                 335     


Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg 
            340                 345                 350         


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser 
        355                 360                 365             


Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    370                 375                 380                 


Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu 
385                 390                 395                 400 


Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu 
                405                 410                 415     


Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
            420                 425                 


<210>  470
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  470

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Phe Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Val Arg Trp Gly Gly Val Thr Thr Tyr Ser Asn Ser Leu Lys 
    50                  55                  60                  


Asp Arg Phe Ser Ile Ser Glu Asp Ser Val Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Arg Gln Met Tyr Met Thr Val Val Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Asp Val His Lys Ile Asn Ile Leu Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Ala Lys Glu Arg Glu Met Val Ala His Ile Thr Ile 
        195                 200                 205             


Gly Asp Ala Thr Asp Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Glu Ala Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Arg Ala Tyr Ser Arg Ile 
                245                 250                 255     


Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


<210>  471
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  471

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Thr Ser Thr Asn Pro Gly Ser Tyr Ile Tyr Ile Trp 
            100                 105                 110         


Ala Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                165                 170                 175     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Val His Lys 
            180                 185                 190         


Ile Asn Ile Leu Gly Trp Tyr Arg Gln Ala Pro Ala Lys Glu Arg Glu 
        195                 200                 205             


Met Val Ala His Ile Thr Ile Gly Asp Ala Thr Asp Tyr Ala Asp Ser 
    210                 215                 220                 


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ala Lys Asn Met Val 
225                 230                 235                 240 


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe 
                245                 250                 255     


Cys Arg Ala Tyr Ser Arg Ile Tyr Pro Tyr Asn Tyr Trp Gly Gln Gly 
            260                 265                 270         


Thr Leu Val Thr Val Ser Ser 
        275                 


<210>  472
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  472

Gly Phe Thr Phe Ser Ser Phe Gly Met Ser 
1               5                   10  


<210>  473
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  473

Gly Phe Thr Phe Arg Ser Phe Gly Met Ser 
1               5                   10  


<210>  474
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  474

Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu 
1               5                   10  


<210>  475
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  475

Gly Gly Ser Leu Ser Arg 
1               5       


<210>  476
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  476

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Arg Ile Leu Lys Ile Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Thr Gln Asp Met Asn His Asn Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Lys Leu Ile Tyr Tyr 
        35                  40                  45              


Ser Val Gly Ala Gly Ile Thr Asp Lys Gly Glu Val Pro Asn Gly Tyr 
    50                  55                  60                  


Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Glu Leu 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Thr Tyr His 
                85                  90                  95      


Gly Thr Gly Tyr Phe Gly Glu Gly Ser Trp Leu Thr Val Val 
            100                 105                 110 


<210>  477
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  477

Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg Lys Glu Gly 
1               5                   10                  15      


Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His Asp Ala Met 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu Ile Tyr Tyr 
        35                  40                  45              


Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala Glu Gly Tyr 
    50                  55                  60                  


Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr Val Thr Ser 
65                  70                  75                  80  


Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser Ser Ser Arg 
                85                  90                  95      


Ser Ser Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr 
            100                 105                 110         


<210>  478
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  478

Val Val Ser Gln His Pro Ser Trp Val Ile Ala Lys Ser Gly Thr Ser 
1               5                   10                  15      


Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe 
            20                  25                  30          


Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser 
        35                  40                  45              


Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys 
    50                  55                  60                  


Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr 
65                  70                  75                  80  


Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Arg Gly 
                85                  90                  95      


Gly Ser Tyr Asn Ser Pro Leu His Phe Gly Asn Gly Thr Arg Leu Thr 
            100                 105                 110         


Val Thr 
        


<210>  479
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  479

Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
1               5                   10                  15      


Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln 
            20                  25                  30          


Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys 
        35                  40                  45              


Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val 
    50                  55                  60                  


Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn 
65                  70                  75                  80  


Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys 
                85                  90                  95      


<210>  480
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  480

Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
1               5                   10                  15      


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
    50                  55                  60                  


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
65                  70                  75                  80  


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
                85                  90                  95      


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
            100                 105                 110         


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
        115                 120                 125             


Ala Asp Cys 
    130     


<210>  481
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  481

Ser Phe Gly Met Ser 
1               5   


<210>  482
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  482

Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  483
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  483

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala 
        


<210>  484
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  484

Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
1               5                   10                  15      


Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln 
            20                  25                  30          


Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys 
        35                  40                  45              


Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val 
    50                  55                  60                  


Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn 
65                  70                  75                  80  


Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys 
                85                  90                  95      


Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn 
            100                 105                 110         


Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val 
        115                 120                 125             


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135                 140         


<210>  485
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  485

Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
1               5                   10                  15      


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
    50                  55                  60                  


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
65                  70                  75                  80  


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
                85                  90                  95      


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
            100                 105                 110         


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
        115                 120                 125             


Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser 
    130                 135                 140                 


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
145                 150                 155                 160 


Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp 
                165                 170                 175     


Phe 
    


<210>  486
<211>  623
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  486

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Thr Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ala Trp Asp Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val His 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Tyr Asn Val Tyr Tyr Asn Asn Tyr Tyr Tyr Pro Ile Ser 
            100                 105                 110         


Arg Asp Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val 
                165                 170                 175     


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Thr 
            180                 185                 190         


Tyr Gly Ser Tyr Trp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
        195                 200                 205             


Arg Glu Gly Val Ala Ala Ile Asn Arg Gly Gly Gly Tyr Thr Val Tyr 
    210                 215                 220                 


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ala Lys 
225                 230                 235                 240 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Asp Asp Thr Ala 
                245                 250                 255     


Asp Tyr Tyr Cys Ala Ala Ser Gly Val Leu Gly Gly Leu His Glu Asp 
            260                 265                 270         


Trp Phe Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
305                 310                 315                 320 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                325                 330                 335     


Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys 
            340                 345                 350         


Ile Asn Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        355                 360                 365             


Lys Val Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser 
    370                 375                 380                 


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val 
385                 390                 395                 400 


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe 
                405                 410                 415     


Cys Arg Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly 
            420                 425                 430         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
465                 470                 475                 480 


Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys 
                485                 490                 495     


Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg 
            500                 505                 510         


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser 
        515                 520                 525             


Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    530                 535                 540                 


Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu 
545                 550                 555                 560 


Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu 
                565                 570                 575     


Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ala Ala 
            580                 585                 590         


Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr 
        595                 600                 605             


Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His His His 
    610                 615                 620             


<210>  487
<211>  589
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  487

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Thr Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ala Trp Asp Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val His 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Tyr Asn Val Tyr Tyr Asn Asn Tyr Tyr Tyr Pro Ile Ser 
            100                 105                 110         


Arg Asp Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val 
                165                 170                 175     


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Thr 
            180                 185                 190         


Tyr Gly Ser Tyr Trp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
        195                 200                 205             


Arg Glu Gly Val Ala Ala Ile Asn Arg Gly Gly Gly Tyr Thr Val Tyr 
    210                 215                 220                 


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ala Lys 
225                 230                 235                 240 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Asp Asp Thr Ala 
                245                 250                 255     


Asp Tyr Tyr Cys Ala Ala Ser Gly Val Leu Gly Gly Leu His Glu Asp 
            260                 265                 270         


Trp Phe Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
305                 310                 315                 320 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                325                 330                 335     


Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Val His Lys 
            340                 345                 350         


Ile Asn Phe Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        355                 360                 365             


Lys Val Ala His Ile Ser Ile Gly Asp Gln Thr Asp Tyr Ala Asp Ser 
    370                 375                 380                 


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Met Val 
385                 390                 395                 400 


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe 
                405                 410                 415     


Cys Arg Ala Phe Ser Arg Ile Tyr Pro Tyr Asp Tyr Trp Gly Gln Gly 
            420                 425                 430         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
465                 470                 475                 480 


Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys 
                485                 490                 495     


Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg 
            500                 505                 510         


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser 
        515                 520                 525             


Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    530                 535                 540                 


Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu 
545                 550                 555                 560 


Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu 
                565                 570                 575     


Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
            580                 585                 


