                         SEQUENCE LISTING

<110>  Universiteit Gent
 
<120>  Mutant sucrose phosphorylases with improved glycosylation 
       activity towards polyphenols

<130>  P2014/061PCT

<150>  EP15167263.1
<151>  2015-05-12

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  488
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mutant of sucrose phosphorylase of bacterium 
       Thermoanaerobacterium thermosaccharolyticum

<400>  1

Met Ala Leu Lys Asn Lys Val Gln Leu Ile Thr Tyr Pro Asp Ser Leu 
1               5                   10                  15      


Gly Gly Asn Leu Lys Thr Leu Asn Asp Val Leu Glu Lys Tyr Phe Ser 
            20                  25                  30          


Asp Val Phe Gly Gly Val His Ile Leu Pro Pro Phe Pro Ser Ser Gly 
        35                  40                  45              


Asp Arg Gly Phe Ala Pro Ile Thr Tyr Ser Glu Ile Glu Pro Lys Phe 
    50                  55                  60                  


Gly Thr Trp Tyr Asp Ile Lys Lys Met Ala Glu Asn Phe Asp Ile Leu 
65                  70                  75                  80  


Leu Asp Leu Met Val Asn His Val Ser Arg Arg Ser Ile Tyr Phe Gln 
                85                  90                  95      


Asp Phe Leu Lys Lys Gly Arg Lys Ser Glu Tyr Ala Asp Met Phe Ile 
            100                 105                 110         


Thr Leu Asp Lys Leu Trp Lys Asp Gly Lys Pro Val Lys Gly Asp Ile 
        115                 120                 125             


Glu Lys Met Phe Leu Ala Arg Thr Leu Pro Tyr Ser Thr Phe Lys Ile 
    130                 135                 140                 


Glu Glu Thr Gly Glu Glu Glu Lys Val Trp Thr Thr Phe Gly Lys Thr 
145                 150                 155                 160 


Asp Pro Ser Glu Gln Ile Asp Leu Asp Val Asn Ser His Leu Val Arg 
                165                 170                 175     


Glu Phe Leu Leu Glu Val Phe Lys Thr Phe Ser Asn Phe Gly Val Lys 
            180                 185                 190         


Ile Val Arg Leu Asp Ala Val Gly Tyr Val Ile Lys Lys Ile Gly Thr 
        195                 200                 205             


Ser Cys Phe Phe Val Glu Pro Glu Ile Tyr Glu Phe Leu Asp Trp Ala 
    210                 215                 220                 


Lys Gly Gln Ala Ala Ser Tyr Gly Ile Glu Leu Leu Leu Glu Val His 
225                 230                 235                 240 


Ser Gln Phe Glu Val Gln Tyr Lys Leu Ala Glu Arg Gly Phe Leu Ile 
                245                 250                 255     


Tyr Asp Phe Ile Leu Pro Phe Thr Val Leu Tyr Thr Leu Ile Asn Lys 
            260                 265                 270         


Ser Asn Glu Met Leu Tyr His Tyr Leu Lys Asn Arg Pro Ile Asn Gln 
        275                 280                 285             


Phe Thr Met Leu Asp Cys His Asp Gly Ile Pro Val Lys Pro Asp Leu 
    290                 295                 300                 


Asp Gly Leu Ile Asp Thr Lys Lys Ala Lys Glu Val Val Asp Ile Cys 
305                 310                 315                 320 


Val Gln Arg Gly Ala Asn Leu Ser Leu Ile Tyr Gly Asp Lys Tyr Lys 
                325                 330                 335     


Ser Glu Asp Gly Phe Asp Val His Gln Ile Asn Cys Thr Tyr Tyr Ser 
            340                 345                 350         


Ala Leu Asn Cys Asp Asp Asp Ala Tyr Leu Ala Ala Arg Ala Ile Gln 
        355                 360                 365             


Phe Phe Thr Pro Gly Ile Pro Gln Val Tyr Tyr Val Gly Leu Leu Ala 
    370                 375                 380                 


Gly Val Asn Asp Phe Glu Ala Val Lys Lys Thr Lys Glu Gly Arg Glu 
385                 390                 395                 400 


Ile Asn Arg His Asn Tyr Gly Leu Lys Glu Ile Glu Glu Ser Val Gln 
                405                 410                 415     


Lys Asn Val Val Gln Arg Leu Leu Lys Leu Ile Arg Phe Arg Asn Glu 
            420                 425                 430         


Tyr Glu Ala Phe Asn Gly Glu Phe Phe Ile Glu Asp Cys Arg Lys Asp 
        435                 440                 445             


Glu Ile Arg Leu Thr Trp Lys Lys Asp Asp Lys Arg Cys Ser Leu Phe 
    450                 455                 460                 


Ile Asp Leu Lys Thr Tyr Lys Thr Thr Ile Asp Tyr Ile Asn Glu Asn 
465                 470                 475                 480 


Gly Glu Glu Val Lys Tyr Leu Val 
                485             


<210>  2
<211>  488
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mutant of sucrose phosphorylase of bacterium 
       Thermoanaerobacterium thermosaccharolyticum

<400>  2

Met Ala Leu Lys Asn Lys Val Gln Leu Ile Thr Tyr Pro Asp Ser Leu 
1               5                   10                  15      


Gly Gly Asn Leu Lys Thr Leu Asn Asp Val Leu Glu Lys Tyr Phe Ser 
            20                  25                  30          


Asp Val Phe Gly Gly Val His Ile Leu Pro Pro Phe Pro Ser Ser Gly 
        35                  40                  45              


Asp Arg Gly Phe Ala Pro Ile Thr Tyr Ser Glu Ile Glu Pro Lys Phe 
    50                  55                  60                  


Gly Thr Trp Tyr Asp Ile Lys Lys Met Ala Glu Asn Phe Asp Ile Leu 
65                  70                  75                  80  


Leu Asp Leu Met Val Asn His Val Ser Arg Arg Ser Ile Tyr Phe Gln 
                85                  90                  95      


Asp Phe Leu Lys Lys Gly Arg Lys Ser Glu Tyr Ala Asp Met Phe Ile 
            100                 105                 110         


Thr Leu Asp Lys Leu Trp Lys Asp Gly Lys Pro Val Lys Gly Asp Ile 
        115                 120                 125             


Glu Lys Met Phe Leu Val Arg Thr Leu Pro Tyr Ser Thr Phe Lys Ile 
    130                 135                 140                 


Glu Glu Thr Gly Glu Glu Glu Lys Val Trp Thr Thr Phe Gly Lys Thr 
145                 150                 155                 160 


Asp Pro Ser Glu Gln Ile Asp Leu Asp Val Asn Ser His Leu Val Arg 
                165                 170                 175     


Glu Phe Leu Leu Glu Val Phe Lys Thr Phe Ser Asn Phe Gly Val Lys 
            180                 185                 190         


Ile Val Arg Leu Asp Ala Val Gly Tyr Val Ile Lys Lys Ile Gly Thr 
        195                 200                 205             


Ser Cys Phe Phe Val Glu Pro Glu Ile Tyr Glu Phe Leu Asp Trp Ala 
    210                 215                 220                 


Lys Gly Gln Ala Ala Ser Tyr Gly Ile Glu Leu Leu Leu Glu Val His 
225                 230                 235                 240 


Ser Gln Phe Glu Val Gln Tyr Lys Leu Ala Glu Arg Gly Phe Leu Ile 
                245                 250                 255     


Tyr Asp Phe Ile Leu Pro Phe Thr Val Leu Tyr Thr Leu Ile Asn Lys 
            260                 265                 270         


Ser Asn Glu Met Leu Tyr His Tyr Leu Lys Asn Arg Pro Ile Asn Gln 
        275                 280                 285             


Phe Thr Met Leu Asp Cys His Asp Gly Ile Pro Val Lys Pro Asp Leu 
    290                 295                 300                 


Asp Gly Leu Ile Asp Thr Lys Lys Ala Lys Glu Val Val Asp Ile Cys 
305                 310                 315                 320 


Val Gln Arg Gly Ala Asn Leu Ser Leu Ile Tyr Gly Asp Lys Tyr Lys 
                325                 330                 335     


Ser Glu Asp Gly Phe Asp Val His Gln Ile Asn Cys Thr Tyr Tyr Ser 
            340                 345                 350         


Ala Leu Asn Cys Asp Asp Asp Ala Tyr Leu Ala Ala Arg Ala Ile Gln 
        355                 360                 365             


Phe Phe Thr Pro Gly Ile Pro Gln Val Tyr Tyr Val Gly Leu Leu Ala 
    370                 375                 380                 


Gly Val Asn Asp Phe Glu Ala Val Lys Lys Thr Lys Glu Gly Arg Glu 
385                 390                 395                 400 


Ile Asn Arg His Asn Tyr Gly Leu Lys Glu Ile Glu Glu Ser Val Gln 
                405                 410                 415     


Lys Asn Val Val Gln Arg Leu Leu Lys Leu Ile Arg Phe Arg Asn Glu 
            420                 425                 430         


Tyr Glu Ala Phe Asn Gly Glu Phe Phe Ile Glu Asp Cys Arg Lys Asp 
        435                 440                 445             


Glu Ile Arg Leu Thr Trp Lys Lys Asp Asp Lys Arg Cys Ser Leu Phe 
    450                 455                 460                 


Ile Asp Leu Lys Thr Tyr Lys Thr Thr Ile Asp Tyr Ile Asn Glu Asn 
465                 470                 475                 480 


Gly Glu Glu Val Lys Tyr Leu Val 
                485             


<210>  3
<211>  488
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mutant of sucrose phosphorylase of bacterium 
       Thermoanaerobacterium thermosaccharolyticum

<400>  3

Met Ala Leu Lys Asn Lys Val Gln Leu Ile Thr Tyr Pro Asp Ser Leu 
1               5                   10                  15      


Gly Gly Asn Leu Lys Thr Leu Asn Asp Val Leu Glu Lys Tyr Phe Ser 
            20                  25                  30          


Asp Val Phe Gly Gly Val His Ile Leu Pro Pro Phe Pro Ser Ser Gly 
        35                  40                  45              


Asp Arg Gly Phe Ala Pro Ile Thr Tyr Ser Glu Ile Glu Pro Lys Phe 
    50                  55                  60                  


Gly Thr Trp Tyr Asp Ile Lys Lys Met Ala Glu Asn Phe Asp Ile Leu 
65                  70                  75                  80  


Leu Asp Leu Met Val Asn His Val Ser Arg Arg Ser Ile Tyr Phe Gln 
                85                  90                  95      


Asp Phe Leu Lys Lys Gly Arg Lys Ser Glu Tyr Ala Asp Met Phe Ile 
            100                 105                 110         


Thr Leu Asp Lys Leu Trp Lys Asp Gly Lys Pro Val Lys Gly Asp Ile 
        115                 120                 125             


Glu Lys Met Phe Leu Thr Arg Thr Leu Pro Tyr Ser Thr Phe Lys Ile 
    130                 135                 140                 


Glu Glu Thr Gly Glu Glu Glu Lys Val Trp Thr Thr Phe Gly Lys Thr 
145                 150                 155                 160 


Asp Pro Ser Glu Gln Ile Asp Leu Asp Val Asn Ser His Leu Val Arg 
                165                 170                 175     


Glu Phe Leu Leu Glu Val Phe Lys Thr Phe Ser Asn Phe Gly Val Lys 
            180                 185                 190         


Ile Val Arg Leu Asp Ala Val Gly Tyr Val Ile Lys Lys Ile Gly Thr 
        195                 200                 205             


Ser Cys Phe Phe Val Glu Pro Glu Ile Tyr Glu Phe Leu Asp Trp Ala 
    210                 215                 220                 


Lys Gly Gln Ala Ala Ser Tyr Gly Ile Glu Leu Leu Leu Glu Val His 
225                 230                 235                 240 


Ser Gln Phe Glu Val Gln Tyr Lys Leu Ala Glu Arg Gly Phe Leu Ile 
                245                 250                 255     


Tyr Asp Phe Ile Leu Pro Phe Thr Val Leu Tyr Thr Leu Ile Asn Lys 
            260                 265                 270         


Ser Asn Glu Met Leu Tyr His Tyr Leu Lys Asn Arg Pro Ile Asn Gln 
        275                 280                 285             


Phe Thr Met Leu Asp Cys His Asp Gly Ile Pro Val Lys Pro Asp Leu 
    290                 295                 300                 


Asp Gly Leu Ile Asp Thr Lys Lys Ala Lys Glu Val Val Asp Ile Cys 
305                 310                 315                 320 


Val Gln Arg Gly Ala Asn Leu Ser Leu Ile Tyr Gly Asp Lys Tyr Lys 
                325                 330                 335     


Ser Glu Asp Gly Phe Asp Val His Gln Ile Asn Cys Thr Tyr Tyr Ser 
            340                 345                 350         


Ala Leu Asn Cys Asp Asp Asp Ala Tyr Leu Ala Ala Arg Ala Ile Gln 
        355                 360                 365             


Phe Phe Thr Pro Gly Ile Pro Gln Val Tyr Tyr Val Gly Leu Leu Ala 
    370                 375                 380                 


Gly Val Asn Asp Phe Glu Ala Val Lys Lys Thr Lys Glu Gly Arg Glu 
385                 390                 395                 400 


Ile Asn Arg His Asn Tyr Gly Leu Lys Glu Ile Glu Glu Ser Val Gln 
                405                 410                 415     


Lys Asn Val Val Gln Arg Leu Leu Lys Leu Ile Arg Phe Arg Asn Glu 
            420                 425                 430         


Tyr Glu Ala Phe Asn Gly Glu Phe Phe Ile Glu Asp Cys Arg Lys Asp 
        435                 440                 445             


Glu Ile Arg Leu Thr Trp Lys Lys Asp Asp Lys Arg Cys Ser Leu Phe 
    450                 455                 460                 


Ile Asp Leu Lys Thr Tyr Lys Thr Thr Ile Asp Tyr Ile Asn Glu Asn 
465                 470                 475                 480 


Gly Glu Glu Val Lys Tyr Leu Val 
                485             


<210>  4
<211>  488
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mutant of sucrose phosphorylase of bacterium 
       Thermoanaerobacterium thermosaccharolyticum

<400>  4

Met Ala Leu Lys Asn Lys Val Gln Leu Ile Thr Tyr Pro Asp Ser Leu 
1               5                   10                  15      


Gly Gly Asn Leu Lys Thr Leu Asn Asp Val Leu Glu Lys Tyr Phe Ser 
            20                  25                  30          


Asp Val Phe Gly Gly Val His Ile Leu Pro Pro Phe Pro Ser Ser Gly 
        35                  40                  45              


Asp Arg Gly Phe Ala Pro Ile Thr Tyr Ser Glu Ile Glu Pro Lys Phe 
    50                  55                  60                  


Gly Thr Trp Tyr Asp Ile Lys Lys Met Ala Glu Asn Phe Asp Ile Leu 
65                  70                  75                  80  


Leu Asp Leu Met Val Asn His Val Ser Arg Arg Ser Ile Tyr Phe Gln 
                85                  90                  95      


Asp Phe Leu Lys Lys Gly Arg Lys Ser Glu Tyr Ala Asp Met Phe Ile 
            100                 105                 110         


Thr Leu Asp Lys Leu Trp Lys Asp Gly Lys Pro Val Lys Gly Asp Ile 
        115                 120                 125             


Glu Lys Met Phe Leu Gly Arg Thr Leu Pro Tyr Ser Thr Phe Lys Ile 
    130                 135                 140                 


Glu Glu Thr Gly Glu Glu Glu Lys Val Trp Thr Thr Phe Gly Lys Thr 
145                 150                 155                 160 


Asp Pro Ser Glu Gln Ile Asp Leu Asp Val Asn Ser His Leu Val Arg 
                165                 170                 175     


Glu Phe Leu Leu Glu Val Phe Lys Thr Phe Ser Asn Phe Gly Val Lys 
            180                 185                 190         


Ile Val Arg Leu Asp Ala Val Gly Tyr Val Ile Lys Lys Ile Gly Thr 
        195                 200                 205             


Ser Cys Phe Phe Val Glu Pro Glu Ile Tyr Glu Phe Leu Asp Trp Ala 
    210                 215                 220                 


Lys Gly Gln Ala Ala Ser Tyr Gly Ile Glu Leu Leu Leu Glu Val His 
225                 230                 235                 240 


Ser Gln Phe Glu Val Gln Tyr Lys Leu Ala Glu Arg Gly Phe Leu Ile 
                245                 250                 255     


Tyr Asp Phe Ile Leu Pro Phe Thr Val Leu Tyr Thr Leu Ile Asn Lys 
            260                 265                 270         


Ser Asn Glu Met Leu Tyr His Tyr Leu Lys Asn Arg Pro Ile Asn Gln 
        275                 280                 285             


Phe Thr Met Leu Asp Cys His Asp Gly Ile Pro Val Lys Pro Asp Leu 
    290                 295                 300                 


Asp Gly Leu Ile Asp Thr Lys Lys Ala Lys Glu Val Val Asp Ile Cys 
305                 310                 315                 320 


Val Gln Arg Gly Ala Asn Leu Ser Leu Ile Tyr Gly Asp Lys Tyr Lys 
                325                 330                 335     


Ser Glu Asp Gly Phe Asp Val His Gln Ile Asn Cys Thr Tyr Tyr Ser 
            340                 345                 350         


Ala Leu Asn Cys Asp Asp Asp Ala Tyr Leu Ala Ala Arg Ala Ile Gln 
        355                 360                 365             


Phe Phe Thr Pro Gly Ile Pro Gln Val Tyr Tyr Val Gly Leu Leu Ala 
    370                 375                 380                 


Gly Val Asn Asp Phe Glu Ala Val Lys Lys Thr Lys Glu Gly Arg Glu 
385                 390                 395                 400 


Ile Asn Arg His Asn Tyr Gly Leu Lys Glu Ile Glu Glu Ser Val Gln 
                405                 410                 415     


Lys Asn Val Val Gln Arg Leu Leu Lys Leu Ile Arg Phe Arg Asn Glu 
            420                 425                 430         


Tyr Glu Ala Phe Asn Gly Glu Phe Phe Ile Glu Asp Cys Arg Lys Asp 
        435                 440                 445             


Glu Ile Arg Leu Thr Trp Lys Lys Asp Asp Lys Arg Cys Ser Leu Phe 
    450                 455                 460                 


Ile Asp Leu Lys Thr Tyr Lys Thr Thr Ile Asp Tyr Ile Asn Glu Asn 
465                 470                 475                 480 


Gly Glu Glu Val Lys Tyr Leu Val 
                485             


<210>  5
<211>  487
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mutant of sucrose phosphorylase of bacterium 
       Thermoanaerobacterium thermosaccharolyticum

<400>  5

Met Ala Leu Lys Asn Lys Val Gln Leu Ile Thr Tyr Pro Asp Ser Leu 
1               5                   10                  15      


Gly Gly Asn Leu Lys Thr Leu Asn Asp Val Leu Glu Lys Tyr Phe Ser 
            20                  25                  30          


Asp Val Phe Gly Gly Val His Ile Leu Pro Pro Phe Pro Ser Ser Gly 
        35                  40                  45              


Asp Arg Gly Phe Ala Pro Ile Thr Tyr Ser Glu Ile Glu Pro Lys Phe 
    50                  55                  60                  


Gly Thr Trp Tyr Asp Ile Lys Lys Met Ala Glu Asn Phe Asp Ile Leu 
65                  70                  75                  80  


Leu Asp Leu Met Val Asn His Val Ser Arg Arg Ser Ile Tyr Phe Gln 
                85                  90                  95      


Asp Phe Leu Lys Lys Gly Arg Lys Ser Glu Tyr Ala Asp Met Phe Ile 
            100                 105                 110         


Thr Leu Asp Lys Leu Trp Lys Asp Gly Lys Pro Val Lys Gly Asp Ile 
        115                 120                 125             


Glu Lys Met Phe Leu Arg Thr Leu Pro Tyr Ser Thr Phe Lys Ile Glu 
    130                 135                 140                 


Glu Thr Gly Glu Glu Glu Lys Val Trp Thr Thr Phe Gly Lys Thr Asp 
145                 150                 155                 160 


Pro Ser Glu Gln Ile Asp Leu Asp Val Asn Ser His Leu Val Arg Glu 
                165                 170                 175     


Phe Leu Leu Glu Val Phe Lys Thr Phe Ser Asn Phe Gly Val Lys Ile 
            180                 185                 190         


Val Arg Leu Asp Ala Val Gly Tyr Val Ile Lys Lys Ile Gly Thr Ser 
        195                 200                 205             


Cys Phe Phe Val Glu Pro Glu Ile Tyr Glu Phe Leu Asp Trp Ala Lys 
    210                 215                 220                 


Gly Gln Ala Ala Ser Tyr Gly Ile Glu Leu Leu Leu Glu Val His Ser 
225                 230                 235                 240 


Gln Phe Glu Val Gln Tyr Lys Leu Ala Glu Arg Gly Phe Leu Ile Tyr 
                245                 250                 255     


Asp Phe Ile Leu Pro Phe Thr Val Leu Tyr Thr Leu Ile Asn Lys Ser 
            260                 265                 270         


Asn Glu Met Leu Tyr His Tyr Leu Lys Asn Arg Pro Ile Asn Gln Phe 
        275                 280                 285             


Thr Met Leu Asp Cys His Asp Gly Ile Pro Val Lys Pro Asp Leu Asp 
    290                 295                 300                 


Gly Leu Ile Asp Thr Lys Lys Ala Lys Glu Val Val Asp Ile Cys Val 
305                 310                 315                 320 


Gln Arg Gly Ala Asn Leu Ser Leu Ile Tyr Gly Asp Lys Tyr Lys Ser 
                325                 330                 335     


Glu Asp Gly Phe Asp Val His Gln Ile Asn Cys Thr Tyr Tyr Ser Ala 
            340                 345                 350         


Leu Asn Cys Asp Asp Asp Ala Tyr Leu Ala Ala Arg Ala Ile Gln Phe 
        355                 360                 365             


Phe Thr Pro Gly Ile Pro Gln Val Tyr Tyr Val Gly Leu Leu Ala Gly 
    370                 375                 380                 


Val Asn Asp Phe Glu Ala Val Lys Lys Thr Lys Glu Gly Arg Glu Ile 
385                 390                 395                 400 


Asn Arg His Asn Tyr Gly Leu Lys Glu Ile Glu Glu Ser Val Gln Lys 
                405                 410                 415     


Asn Val Val Gln Arg Leu Leu Lys Leu Ile Arg Phe Arg Asn Glu Tyr 
            420                 425                 430         


Glu Ala Phe Asn Gly Glu Phe Phe Ile Glu Asp Cys Arg Lys Asp Glu 
        435                 440                 445             


Ile Arg Leu Thr Trp Lys Lys Asp Asp Lys Arg Cys Ser Leu Phe Ile 
    450                 455                 460                 


Asp Leu Lys Thr Tyr Lys Thr Thr Ile Asp Tyr Ile Asn Glu Asn Gly 
465                 470                 475                 480 


Glu Glu Val Lys Tyr Leu Val 
                485         


<210>  6
<211>  488
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mutant of sucrose phosphorylase of bacterium 
       Thermoanaerobacterium thermosaccharolyticum


<220>
<221>  MISC_FEATURE
<222>  (134)..(134)
<223>  X represents A,V,T or G

<400>  6

Met Ala Leu Lys Asn Lys Val Gln Leu Ile Thr Tyr Pro Asp Ser Leu 
1               5                   10                  15      


Gly Gly Asn Leu Lys Thr Leu Asn Asp Val Leu Glu Lys Tyr Phe Ser 
            20                  25                  30          


Asp Val Phe Gly Gly Val His Ile Leu Pro Pro Phe Pro Ser Ser Gly 
        35                  40                  45              


Asp Arg Gly Phe Ala Pro Ile Thr Tyr Ser Glu Ile Glu Pro Lys Phe 
    50                  55                  60                  


Gly Thr Trp Tyr Asp Ile Lys Lys Met Ala Glu Asn Phe Asp Ile Leu 
65                  70                  75                  80  


Leu Asp Leu Met Val Asn His Val Ser Arg Arg Ser Ile Tyr Phe Gln 
                85                  90                  95      


Asp Phe Leu Lys Lys Gly Arg Lys Ser Glu Tyr Ala Asp Met Phe Ile 
            100                 105                 110         


Thr Leu Asp Lys Leu Trp Lys Asp Gly Lys Pro Val Lys Gly Asp Ile 
        115                 120                 125             


Glu Lys Met Phe Leu Xaa Arg Thr Leu Pro Tyr Ser Thr Phe Lys Ile 
    130                 135                 140                 


Glu Glu Thr Gly Glu Glu Glu Lys Val Trp Thr Thr Phe Gly Lys Thr 
145                 150                 155                 160 


Asp Pro Ser Glu Gln Ile Asp Leu Asp Val Asn Ser His Leu Val Arg 
                165                 170                 175     


Glu Phe Leu Leu Glu Val Phe Lys Thr Phe Ser Asn Phe Gly Val Lys 
            180                 185                 190         


Ile Val Arg Leu Asp Ala Val Gly Tyr Val Ile Lys Lys Ile Gly Thr 
        195                 200                 205             


Ser Cys Phe Phe Val Glu Pro Glu Ile Tyr Glu Phe Leu Asp Trp Ala 
    210                 215                 220                 


Lys Gly Gln Ala Ala Ser Tyr Gly Ile Glu Leu Leu Leu Glu Val His 
225                 230                 235                 240 


Ser Gln Phe Glu Val Gln Tyr Lys Leu Ala Glu Arg Gly Phe Leu Ile 
                245                 250                 255     


Tyr Asp Phe Ile Leu Pro Phe Thr Val Leu Tyr Thr Leu Ile Asn Lys 
            260                 265                 270         


Ser Asn Glu Met Leu Tyr His Tyr Leu Lys Asn Arg Pro Ile Asn Gln 
        275                 280                 285             


Phe Thr Met Leu Asp Cys His Asp Gly Ile Pro Val Lys Pro Asp Leu 
    290                 295                 300                 


Asp Gly Leu Ile Asp Thr Lys Lys Ala Lys Glu Val Val Asp Ile Cys 
305                 310                 315                 320 


Val Gln Arg Gly Ala Asn Leu Ser Leu Ile Tyr Gly Asp Lys Tyr Lys 
                325                 330                 335     


Ser Glu Asp Gly Phe Asp Val His Gln Ile Asn Cys Thr Tyr Tyr Ser 
            340                 345                 350         


Ala Leu Asn Cys Asp Asp Asp Ala Tyr Leu Ala Ala Arg Ala Ile Gln 
        355                 360                 365             


Phe Phe Thr Pro Gly Ile Pro Gln Val Tyr Tyr Val Gly Leu Leu Ala 
    370                 375                 380                 


Gly Val Asn Asp Phe Glu Ala Val Lys Lys Thr Lys Glu Gly Arg Glu 
385                 390                 395                 400 


Ile Asn Arg His Asn Tyr Gly Leu Lys Glu Ile Glu Glu Ser Val Gln 
                405                 410                 415     


Lys Asn Val Val Gln Arg Leu Leu Lys Leu Ile Arg Phe Arg Asn Glu 
            420                 425                 430         


Tyr Glu Ala Phe Asn Gly Glu Phe Phe Ile Glu Asp Cys Arg Lys Asp 
        435                 440                 445             


Glu Ile Arg Leu Thr Trp Lys Lys Asp Asp Lys Arg Cys Ser Leu Phe 
    450                 455                 460                 


Ile Asp Leu Lys Thr Tyr Lys Thr Thr Ile Asp Tyr Ile Asn Glu Asn 
465                 470                 475                 480 


Gly Glu Glu Val Lys Tyr Leu Val 
                485             


