﻿               SEQUENCE LISTING

<110> Medizinische Universität Graz

<120> Microbial Nano-Tool

<130> Y1429 PCT S3

<150> EP15 16 6985.0
<151> 2015-05-08

<160> 11

<170> BiSSAP 1.3

<210> 1
<211> 896
<212> PRT
<213> Euryarchaeota SM1

<400> 1
Met Gly Lys Phe Lys Lys Val Cys Ala Thr Ile Gly Gly Ala Ala Ile 
1               5                   10                  15      
Ile Ser Ala Ala Ile Met Gly Met Val Ser Ala Ser Thr Thr Gly Leu 
            20                  25                  30          
Asp Lys Leu Asp Lys Ser Phe Val Tyr Asp Ala Asn Tyr Asn Pro Asn 
        35                  40                  45              
Val His Ile Val Val Gly Glu Lys Ala Ala Ala Ala Asp Val Val Gly 
    50                  55                  60                  
Ala Gly Asp Ile Ala Ala Thr Ile Gly Asn Leu Ala Tyr Thr Thr Gly 
65                  70                  75                  80  
Ala Cys Gly Ala Asn Gly Gly Ser Ala Gly Glu Val Lys Leu Ala Val 
                85                  90                  95      
Lys Ser Trp Gln Met Ile Gly Lys Tyr Glu Gln Asp Ile Lys Asp Arg 
            100                 105                 110         
Val Ile Gly Thr Thr Asn Leu Glu Gly Ser Phe Leu Ser Ser Thr Phe 
        115                 120                 125             
Tyr Ser Thr Asp Gly Gln Leu Leu Ala Asn Gly Thr Leu Thr Tyr Thr 
    130                 135                 140                 
Gln Gly Met Leu Lys Asn Tyr Asn Ile Gly Cys Gln Ile Asp Lys Thr 
145                 150                 155                 160 
Val Ser Asn Phe Pro Met Lys Val Asn Asn Cys Asn Glu Leu Cys Tyr 
                165                 170                 175     
Leu Cys Tyr Asp Ile Cys His Glu Thr Lys His Pro Asp His Glu Met 
            180                 185                 190         
Glu Glu Ser Ile Ile Val Asp Gly Thr Lys Val Lys Tyr Tyr Glu Asp 
        195                 200                 205             
Gly Leu Gly Gly Glu Ser Arg Ala Glu Ser Leu Lys Met Lys Leu His 
    210                 215                 220                 
His Gly Ala Leu Gln Tyr Thr Val Asn Leu Gly Gly Ile Pro Val Ala 
225                 230                 235                 240 
Ala Ile Thr Glu Gly Asp Asn Leu Ile Asp Ser Ser Tyr Arg Gly Lys 
                245                 250                 255     
Met Leu Phe Met Gly Ser Asn Asp Tyr Phe Val Asn Asn Ile Asp Lys 
            260                 265                 270         
Thr Tyr Ile Val Leu Ala Lys Gly Glu Lys Leu Met Ile Asn Asn Ala 
        275                 280                 285             
Gly Ala Ile Glu Pro Thr Leu Pro Glu Leu Gln Gly Tyr Lys Phe Lys 
    290                 295                 300                 
Leu Leu Arg Thr Val Gln Ser Ser Gly Lys Asp Ala Gly Val Val Met 
305                 310                 315                 320 
Glu Ile Glu Lys Pro Asp Gly Thr Thr Val Gln Ala Thr Ala Ser Lys 
                325                 330                 335     
Gln Ala Gly Ala Ser Leu Gly Thr Asp Ala Lys Gly His Lys Ile Gln 
            340                 345                 350         
Ile Gln Ala Phe Gln Val Thr Gly Asn Glu Ala Ser Ile Ile Ala Tyr 
        355                 360                 365             
Asp Met Ser Thr Gln Tyr Arg Leu Glu His Asn Lys Lys Pro Asp Gly 
    370                 375                 380                 
Trp Arg Val Ile Ile Glu Pro Lys Lys Cys Asn Asp Val Lys Val Asp 
385                 390                 395                 400 
Asp Tyr Gly Thr Pro Ala Leu Ser Ile Gly Asn Ala Leu Asn Lys Trp 
                405                 410                 415     
Cys Leu Thr Lys Leu Thr Leu Thr Gln Glu Asp Ala Gln Thr Leu Asn 
            420                 425                 430         
Ile Gly Asp Thr Val Tyr Phe Pro Thr Lys Ala Val Lys Phe Ser Phe 
        435                 440                 445             
Glu Gly Phe Lys Asp Glu Asp Phe Gly Glu Leu Thr Cys Ser Gly Arg 
    450                 455                 460                 
Ser Asp Lys Ile Lys Ile Glu Thr Ser Asp Asn Arg Lys Val Met Leu 
465                 470                 475                 480 
Ser Phe Thr Ala Arg Asp Gly Glu Arg Leu Asn Asn Val Arg Leu Asp 
                485                 490                 495     
Glu Gly Ala Tyr Glu Leu Asp Glu Leu Phe Leu Ile Gly Asn Thr Val 
            500                 505                 510         
Tyr Lys Phe Arg Gly Thr Glu Asp Ile Thr Asn Asp Val Asn Asn Val 
        515                 520                 525             
Lys Leu Leu Leu Thr Asp Val Ser Asn Ala Asn Asp Phe Glu Val Thr 
    530                 535                 540                 
Leu Thr Lys Leu Asn Gly Ser Phe Ser Gly Phe Asn Tyr Thr Tyr Phe 
545                 550                 555                 560 
Asp Lys Tyr Ser Thr Ser Met Glu Asn Ser Cys Thr Ser Cys Ser Ile 
                565                 570                 575     
Phe Asn Gly Thr Val Gln Gln Ile Pro Gly Lys Met Ala Tyr Phe His 
            580                 585                 590         
Glu Asn Lys Leu Trp Ile Asp Ala Gly Thr Asp Ser Lys Ile Gly Leu 
        595                 600                 605             
Asn Asn Ile Ala Leu Thr Asp Ile Gln Asn Asp Asn Cys Gln Ala Lys 
    610                 615                 620                 
Leu Thr Thr Leu Phe Glu Asn Gly Ser Asn Leu Asn Gly Glu Thr Thr 
625                 630                 635                 640 
Asn Asn Asn Ser Asp Asp Gln Ile Leu Val Phe Glu Gly Cys Gly Glu 
                645                 650                 655     
Asp Arg Thr Tyr Ile Asp Phe Tyr Asp Thr Asn Arg Lys Ala Arg Gly 
            660                 665                 670         
Thr Gly Asp Tyr Gln Thr Ser Val Lys Ile Thr Gly Thr Asp Thr Ser 
        675                 680                 685             
Pro Val Ala Asn Thr Ser Cys Leu Gly Ser Gly Ile Val Cys His Asn 
    690                 695                 700                 
Ser Thr Ser Leu Gly Phe Glu Gly Val Leu Lys Tyr Ser Glu Asp Thr 
705                 710                 715                 720 
Lys Leu Trp Ser Pro Arg Gly Ala Asp Leu Phe Thr Val Thr Asn Tyr 
                725                 730                 735     
Gly Ser Asp Lys Gln Val Lys Ala Val Glu Ile Cys His Pro Thr Lys 
            740                 745                 750         
Lys Thr Tyr Val Thr Tyr Phe Leu Gly Lys Glu Lys Thr Glu Ser Glu 
        755                 760                 765             
Gln Leu Gly Thr Ile Thr Ala Asp Asp Val Gly Lys Leu Lys Thr Ile 
    770                 775                 780                 
Gly Cys Cys Glu Ala Thr Val Lys Ser Phe Gly Leu Ser Ala Gly Asn 
785                 790                 795                 800 
Ala Thr Asn Thr Thr Gly Thr Cys Thr Asn Met Lys Pro Val Gly Thr 
                805                 810                 815     
Leu Met Val Leu Asp Lys Asn Ala Val Thr Gly Asn Leu Ile Val Val 
            820                 825                 830         
Gly Gly Pro Ser Val Asn Thr Leu Ala Ala Ser Ala Gly Val Thr Lys 
        835                 840                 845             
Glu Glu Ile Gly Ala Asp Ala Asn Lys Tyr Val Ile Lys Met Val Gly 
    850                 855                 860                 
Asn Asn Thr Leu Val Val Ala Gly Trp Glu Ala Glu Asp Thr Asn Lys 
865                 870                 875                 880 
Ala Thr Gly Ile Val Val Gln Trp Leu Leu Ala Asn Ala His Asn Ala 
                885                 890                 895     



<210> 2
<211> 2691
<212> DNA
<213> Euryarchaeota SM1

<400> 2
atgggaaaat ttaaaaaggt atgtgcgaca ataggaggag cggcaataat cagtgctgca      60

attatgggaa tggtcagcgc atcaacaacg ggtttggata aattagataa gagttttgta     120

tatgacgcaa actacaatcc gaatgtacat attgtagtag gtgaaaaagc agcggcagca     180

gatgttgtgg gagcaggaga tatagcggca acaatcggaa atctggcata tacaacagga     240

gcatgcggag caaacggagg atcagcagga gaagtaaagt tagcagtgaa gagctggcaa     300

atgatcggaa aatatgaaca ggatataaaa gacagagtta tcggaacaac taatttggaa     360

gggtcttttt taagttctac cttttacagc acagacggac aactacttgc aaacgggaca     420

ttaacatata ctcagggaat gcttaaaaat tacaatatag gatgtcaaat tgacaagaca     480

gtatctaatt ttccaatgaa agttaataac tgtaatgaat tatgttatct ttgttatgat     540

atatgtcatg agacaaaaca tcccgatcat gagatggaag agtctataat tgtagacgga     600

acaaaagtaa aatattatga agatggatta ggaggcgaga gcagagcgga atcattaaag     660

atgaagctac accacggagc actacaatac acagttaatc ttggtggaat tcctgtagca     720

gctataaccg aaggtgataa tttaattgat agtagttata ggggaaagat gttgtttatg     780

ggttcaaatg actattttgt taataacatt gacaagacct acattgtctt ggcaaaaggt     840

gaaaaattaa tgataaacaa tgcaggtgca atagaaccga cattgccaga gttacaggga     900

tataaattta aattacttag aacagttcag agtagtggaa aagatgcagg agttgtaatg     960

gagattgaaa aaccagatgg aacaactgtt caggcaacag catcaaaaca ggcaggtgct    1020

tctcttggaa cggacgcaaa gggtcacaag atacaaatac aggcattcca ggttacggga    1080

aacgaagcaa gtataattgc ttatgatatg agcacgcagt acagattaga acataataaa    1140

aaaccagacg gatggagagt tataatagaa ccaaaaaaat gtaatgatgt aaaagtagat    1200

gattatggaa cacctgcatt atcaattgga aatgcattga ataaatggtg tttaacaaaa    1260

ttgacattga cccaagaaga tgctcaaaca ctgaatatag gtgatactgt atatttcccg    1320

acaaaagcag taaagttttc atttgagggc tttaaagatg aggatttcgg agaactgact    1380

tgttcaggta gaagtgataa aataaagata gaaacaagcg ataatcgtaa agtaatgttg    1440

agctttactg caagggatgg agaacgatta aataatgtca gattggatga aggtgcttat    1500

gaacttgacg agttattcct gataggaaat acagtatata aattcagagg aacagaagat    1560

attactaacg atgtgaataa tgtaaaatta ttgctgactg atgttagcaa tgcaaatgac    1620

tttgaagtaa cacttacaaa attaaatgga tctttttcag gatttaatta tacttacttt    1680

gacaaatata gtacaagtat ggaaaattcg tgcacttcat gttctatatt taatggaaca    1740

gtacaacaaa taccaggaaa aatggcatat ttccacgaaa ataagttatg gattgatgct    1800

ggaactgata gtaaaattgg cttaaataat attgctttaa cagatattca gaatgataac    1860

tgccaggcaa aattaactac attatttgaa aatggatcaa atctaaatgg agaaacaaca    1920

aataacaact cggatgatca aattttagta tttgaaggtt gcggagaaga tagaacttat    1980

attgactttt acgatacaaa taggaaagcc agaggtaccg gtgattatca gacaagtgtt    2040

aaaattacag gaacagatac ctcaccagtc gctaatacat catgtttagg ttcaggaata    2100

gtatgtcata attcaacatc cttaggattt gaaggtgtct tgaaatacag cgaagataca    2160

aaattgtggt caccaagagg ggcggactta ttcacagtaa caaattacgg ctcagataaa    2220

caagtgaagg cagttgaaat ttgccacccc acaaagaaga cttatgtaac ttacttcctt    2280

ggaaaagaaa aaacagaaag tgaacagctt ggaacaatta ctgctgatga tgttggaaaa    2340

ttaaagacga ttggatgctg tgaagcaact gtaaagtcat tcggattaag tgcaggcaat    2400

gcaacaaaca caaccggaac atgtacgaat atgaaaccgg tcggaacatt gatggtgctt    2460

gataaaaatg cagttacagg taatttgatt gttgtcggag gaccatcggt taatacatta    2520

gcagctagtg caggtgttac aaaagaagaa attggtgcag atgcaaacaa gtatgtgatt    2580

aagatggtgg gtaacaatac acttgttgtt gcaggatggg aagcagaaga tacaaataag    2640

gcaaccggta tagttgttca gtggttactg gcaaacgcac ataatgcata a             2691


<210> 3
<211> 363
<212> PRT
<213> Euryarchaeota SM1

<400> 3
Met Gly Ser Asn Glu Tyr Phe Val Asn Gly Leu Asp Lys Thr Tyr Ile 
1               5                   10                  15      
Val Leu Ala Lys Gly Glu Lys Leu His Ile Ser Ser Ala Gly Ala Thr 
            20                  25                  30          
Glu Pro Ala Leu Ser Gln Leu Gln Gly Tyr Lys Phe Lys Leu Leu Lys 
        35                  40                  45              
Thr Ile Gln Ala Tyr Gly Asn Asp Ala Gly Val Ile Ile Glu Ile Glu 
    50                  55                  60                  
Arg Pro Asp Gly Thr Thr Ile Gln Ala Thr Ala Ser Lys Gln Ala Gly 
65                  70                  75                  80  
Ala Ser Leu Gly Thr Asp Ala Asn Gly His Lys Ile Gln Ile Gln Ala 
                85                  90                  95      
Phe His Val Ile Gly Asn Lys Ala Ser Ile Ile Val Tyr Asp Met Ser 
            100                 105                 110         
Thr Arg Tyr Lys Leu Glu Asn Asn Glu Lys Gln Asp Gly Trp Arg Val 
        115                 120                 125             
Lys Ile Asn Asn Ala Lys Cys Asn Asn Val Gly Ile Glu Asp Tyr Leu 
    130                 135                 140                 
Val Pro Asn Ala Ala Asn Lys Tyr Cys Leu Thr Lys Leu Thr Leu Thr 
145                 150                 155                 160 
Gln Glu Asp Ala Gln Thr Leu Asn Val Gly Asp Thr Val Tyr Phe Pro 
                165                 170                 175     
Thr Lys Ala Val Lys Phe Ser Phe Lys Gly Phe Lys Asn Glu Asp Phe 
            180                 185                 190         
Gly Asp Met Val Cys Ser Gly Gly Ser Asp Lys Ile Lys Ile Glu Thr 
        195                 200                 205             
Ser Asp Asn Arg Lys Val Met Leu Ser Phe Thr Thr Arg Asp Gly Glu 
    210                 215                 220                 
Arg Leu Asn Asn Val Arg Leu Asp Glu Gly Gly Tyr Glu Leu Asp Glu 
225                 230                 235                 240 
Leu Phe Leu Ile Gly Asn Thr Val Tyr Lys Phe Arg Gly Thr Glu Asp 
                245                 250                 255     
Ile Asn Asn Asp Glu Asn His Val Lys Leu Leu Leu Thr Asp Val Ser 
            260                 265                 270         
Asn Ala Asn Asp Phe Glu Ala Thr Leu Thr Lys Leu Ser Thr Ser Phe 
        275                 280                 285             
Ala Gly Phe Asn Tyr Thr Tyr Phe Asp His Tyr Ser Val Ser Lys Glu 
    290                 295                 300                 
Asn Gln Cys Ser Pro Pro Cys Ser Thr Tyr Asn Ala Thr Val Leu Gly 
305                 310                 315                 320 
Val Met Ala Tyr Phe His Glu Gly Lys Leu Trp Met Asp Thr Gly Asn 
                325                 330                 335     
Asp Ser Lys Ile Gly Leu Asn Asn Ile Ala Leu Lys Asp Ile Gln Asn 
            340                 345                 350         
Asp Asn Cys Asn Ala Thr Leu Thr Pro Phe Ala 
        355                 360             

<210> 4
<211> 1092
<212> DNA
<213> Euryarchaeota SM1

<400> 4
atgggttcaa atgaatattt tgttaatggc ttggacaaga cctacattgt cttggcaaaa      60

ggtgaaaaat tacatataag tagcgcgggt gcaacagaac cggcattgtc acagttacaa     120

ggatataaat tcaaattact taaaacaatt caggcttacg gaaacgatgc aggagttata     180

atagaaattg aaagaccaga tggaacaact attcaggcaa cagcatcaaa acaggcaggt     240

gcttctcttg gaacggacgc aaatggtcac aagatacaaa tacaggcatt ccatgttata     300

ggaaacaaag caagtataat tgtttatgat atgagtacac ggtacaaatt agaaaataat     360

gaaaagcaag acggatggag agttaaaata aacaatgcca agtgtaataa tgtaggtata     420

gaggattatt tggttccaaa tgctgcaaac aaatattgtc tgacaaagtt aacattgaca     480

caggaagatg ctcaaacatt aaatgtcgga gatactgtat atttcccgac aaaagcagta     540

aagttttcat ttaagggctt taaaaatgag gatttcggag atatggtttg ttcaggcgga     600

agtgataaaa taaagataga gacaagtgat aatcgtaaag taatgttgag ctttactaca     660

agagacggag aacgactgaa taatgtcaga ttggatgaag gtggttatga acttgacgag     720

ttattcctga taggaaatac cgtatacaaa ttcagaggaa cagaagatat taataacgat     780

gaaaatcatg taaaattgtt gctgactgat gttagtaatg caaacgactt tgaagcaaca     840

cttacaaaat taagcacaag ttttgcagga tttaattata cttactttga ccattatagt     900

gtaagtaagg aaaatcagtg cagtcctcca tgttctacat ataatgcgac agtattagga     960

gtaatggcat atttccacga aggtaagtta tggatggata ctggaaatga tagtaaaatt    1020

ggcttaaata atattgcttt aaaagatatt cagaatgata actgcaatgc aacattaact    1080

ccatttgctt ga                                                        1092


<210> 5
<211> 2691
<212> DNA
<213> Artificial Sequence

<220> 
<223> codon optimized sequence for expression in E. Coli

<400> 5
atgggcaaat tcaaaaaagt gtgtgcaacc attggtggcg cagcaattat tagcgcagcc      60

attatgggta tggttagcgc aagcaccacc ggtctggata aactggacaa aagctttgtt     120

tatgacgcca actataatcc gaacgtgcat attgttgttg gtgaaaaagc agcagcagca     180

gatgttgttg gtgccggtga tattgcagcc accattggta atctggcata taccaccggt     240

gcatgtggtg caaatggtgg tagtgccggt gaagttaaac tggcagttaa aagctggcag     300

atgatcggta aatatgagca ggatattaaa gatcgtgtta tcggcaccac caatctggaa     360

ggtagctttc tgagcagcac cttttatagc accgatggtc agctgctggc aaatggcacc     420

ctgacctata cccagggtat gctgaaaaat tacaatattg gctgccagat cgataaaacc     480

gttagcaatt ttccgatgaa agtgaacaat tgcaacgagc tgtgttatct gtgctatgat     540

atttgccatg aaaccaaaca tccggatcac gaaatggaag aaagcattat tgttgatggc     600

accaaagtga aatactatga agatggtctg ggtggtgaaa gccgtgcaga aagcctgaaa     660

atgaaactgc atcatggtgc actgcagtat accgttaatc tgggtggtat tccggttgca     720

gcaattaccg aaggtgataa tctgattgat agcagctatc gtggcaaaat gctgtttatg     780

ggtagcaacg attattttgt gaataacatt gataaaacct atattgtgct ggccaaaggc     840

gaaaaactga tgattaacaa tgccggtgca attgaaccga ccctgccgga actgcagggc     900

tataaattca aactgctgcg taccgttcag agcagcggta aagatgccgg tgttgttatg     960

gaaattgaaa aaccggatgg caccaccgtt caggcaaccg caagcaaaca ggcaggcgca    1020

agcctgggca ccgatgcaaa aggtcataaa attcagattc aggcctttca ggttaccggt    1080

aatgaagcca gcattattgc ctatgatatg agcacccagt atcgtctgga acataacaaa    1140

aaacctgatg gttggcgtgt gattatcgaa ccgaaaaaat gcaatgatgt gaaagtggat    1200

gattatggta caccggcact gagcattggt aatgcactga ataaatggtg tctgaccaaa    1260

ctgaccctga cccaagaaga tgcacagacc ctgaatattg gtgataccgt ttattttccg    1320

accaaagccg tgaaatttag ctttgagggt ttcaaagatg aagattttgg tgaactgacc    1380

tgtagcggtc gtagcgacaa aatcaaaatt gaaaccagcg ataaccgcaa agtgatgctg    1440

agctttaccg cacgtgatgg tgaacgtctg aataatgttc gtctggatga aggtgcctat    1500

gaactggatg aactgtttct gattggtaat accgtgtata aattccgtgg caccgaagat    1560

atcaccaacg atgttaataa tgtgaaactg ctgctgaccg atgttagcaa tgcaaatgat    1620

tttgaagtga ccctgacgaa actgaatggt agctttagcg gtttcaacta tacctatttc    1680

gacaaatata gcaccagcat ggaaaatagc tgtaccagct gtagcatttt taacggcacc    1740

gttcagcaga ttccgggtaa aatggcatat tttcacgaaa ataaactgtg gattgatgca    1800

ggcacggata gcaaaattgg tctgaacaat attgccctga ccgatattca gaatgataat    1860

tgtcaggcaa aactgaccac cctgtttgaa aatggtagca atctgaatgg tgaaaccacg    1920

aataacaaca gcgacgatca gattctggtt tttgaaggtt gtggtgaaga tcgcacctat    1980

atcgattttt atgataccaa tcgtaaagca cgtggcaccg gtgattatca gaccagcgtg    2040

aaaattaccg gcaccgatac cagtccggtt gcaaatacca gctgtctggg tagcggtatt    2100

gtttgtcata atagcaccag cctgggtttt gaaggtgttc tgaaatatag cgaagatacc    2160

aaactgtggt cccctcgtgg tgcagacctg tttaccgtta ccaattatgg tagcgataaa    2220

caggttaaag cggtggaaat ttgtcatccg accaaaaaaa cctatgtgac ctattttctg    2280

ggcaaagaaa aaaccgaaag cgaacagctg ggcaccatta ccgcagatga tgttggtaaa    2340

ctgaaaacca ttggttgttg tgaagcaacc gttaaaagct ttggtctgag cgcaggtaat    2400

gcaaccaata ccaccggtac gtgtaccaat atgaaaccgg ttggcaccct gatggttctg    2460

gataaaaatg cagtgaccgg taatctgatt gttgtgggtg gtccgagcgt taataccctg    2520

gcagcaagtg cgggtgttac caaagaagaa attggcgcag acgcaaacaa atatgtgatt    2580

aaaatggtgg gcaataacac cctggttgtt gcaggttggg aagcagaaga taccaataaa    2640

gcaaccggta ttgttgttca gtggctgctg gccaatgcac ataatgcata a             2691


<210> 6
<211> 2697
<212> DNA
<213> Artificial Sequence

<220> 
<223> codon optimized sequence for expression in eukaryotic cells

<400> 6
aagcttgcca ccatggaaac cgacaccctg ctgctgtggg tgctgctgct ctgggtcccc      60

ggcagcaccg gcttggataa attagataag agttttgtat atgacgcaaa ctacaatccg     120

aatgtacata ttgtagtagg tgaaaaagca gcggcagcag atgttgtggg agcaggagat     180

atagcggcaa caatcggaaa tctggcatat acaacaggag catgcggagc aaacggagga     240

tcagcaggag aagtaaagtt agcagtgaag agctggcaaa tgatcggaaa atatgaacag     300

gatataaaag acagagttat cggaacaact aatttggaag ggtctttttt aagttctacc     360

ttttacagca cagacggaca actacttgca aacgggacat taacatatac tcagggaatg     420

cttaaaaatt acaatatagg atgtcaaatt gacaagacag tatctaattt tccaatgaaa     480

gttaataact gtaatgaatt atgttatctt tgttatgata tatgtcatga gacaaaacat     540

cccgatcatg agatggaaga gtctataatt gtagacggaa caaaagtaaa atattatgaa     600

gatggattag gaggcgagag cagagcggaa tcattaaaga tgaagctaca ccacggagca     660

ctacaataca cagttaatct tggtggaatt cctgtagcag ctataaccga aggtgataat     720

ttaattgata gtagttatag gggaaagatg ttgtttatgg gttcaaatga ctattttgtt     780

aataacattg acaagaccta cattgtcttg gcaaaaggtg aaaaattaat gataaacaat     840

gcaggtgcaa tagaaccgac attgccagag ttacagggat ataaatttaa attacttaga     900

acagttcaga gtagtggaaa agatgcagga gttgtaatgg agattgaaaa accagatgga     960

acaactgttc aggcaacagc atcaaaacag gcaggtgctt ctcttggaac ggacgcaaag    1020

ggtcacaaga tacaaataca ggcattccag gttacgggaa acgaagcaag tataattgct    1080

tatgatatga gcacgcagta cagattagaa cataataaaa aaccagacgg atggagagtt    1140

ataatagaac caaaaaaatg taatgatgta aaagtagatg attatggaac acctgcatta    1200

tcaattggaa atgcattgaa taaatggtgt ttaacaaaat tgacattgac ccaagaagat    1260

gctcaaacac tgaatatagg tgatactgta tatttcccga caaaagcagt aaagttttca    1320

tttgagggct ttaaagatga ggatttcgga gaactgactt gttcaggtag aagtgataaa    1380

ataaagatag aaacaagcga taatcgtaaa gtaatgttga gctttactgc aagggatgga    1440

gaacgattaa ataatgtcag attggatgaa ggtgcttatg aacttgacga gttattcctg    1500

ataggaaata cagtatataa attcagagga acagaagata ttactaacga tgtgaataat    1560

gtaaaattat tgctgactga tgttagcaat gcaaatgact ttgaagtaac acttacaaaa    1620

ttaaatggat ctttttcagg atttaattat acttactttg acaaatatag tacaagtatg    1680

gaaaattcgt gcacttcatg ttctatattt aatggaacag tacaacaaat accaggaaaa    1740

atggcatatt tccacgaaaa taagttatgg attgatgctg gaactgatag taaaattggc    1800

ttaaataata ttgctttaac agatattcag aatgataact gccaggcaaa attaactaca    1860

ttatttgaaa atggatcaaa tctaaatgga gaaacaacaa ataacaactc ggatgatcaa    1920

attttagtat ttgaaggttg cggagaagat agaacttata ttgactttta cgatacaaat    1980

aggaaagcca gaggtaccgg tgattatcag acaagtgtta aaattacagg aacagatacc    2040

tcaccagtcg ctaatacatc atgtttaggt tcaggaatag tatgtcataa ttcaacatcc    2100

ttaggatttg aaggtgtctt gaaatacagc gaagatacaa aattgtggtc accaagaggg    2160

gcggacttat tcacagtaac aaattacggc tcagataaac aagtgaaggc agttgaaatt    2220

tgccacccca caaagaagac ttatgtaact tacttccttg gaaaagaaaa aacagaaagt    2280

gaacagcttg gaacaattac tgctgatgat gttggaaaat taaagacgat tggatgctgt    2340

gaagcaactg taaagtcatt cggattaagt gcaggcaatg caacaaacac aaccggaaca    2400

tgtacgaata tgaaaccggt cggaacattg atggtgcttg ataaaaatgc agttacaggt    2460

aatttgattg ttgtcggagg accatcggtt aatacattag cagctagtgc aggtgttaca    2520

aaagaagaaa ttggtgcaga tgcaaacaag tatgtgatta agatggtggg taacaataca    2580

cttgttgttg caggatggga agcagaagat acaaataagg caaccggtat agttgttcag    2640

tggttactgg caaacgcaca taatgcacat caccaccacc atcactgatg actcgag       2697


<210> 7
<211> 365
<212> PRT
<213> Artificial Sequence

<220> 
<223> conserved region of hamus protein

<400> 7
Met Gly Ser Asn Asp Tyr Phe Val Asn Asn Ile Asp Lys Thr Tyr Ile 
1               5                   10                  15      
Val Leu Ala Lys Gly Glu Lys Leu Met Ile Asn Asn Ala Gly Ala Ile 
            20                  25                  30          
Glu Pro Thr Leu Pro Glu Leu Gln Gly Tyr Lys Phe Lys Leu Leu Arg 
        35                  40                  45              
Thr Val Gln Ser Ser Gly Lys Asp Ala Gly Val Val Met Glu Ile Glu 
    50                  55                  60                  
Lys Pro Asp Gly Thr Thr Val Gln Ala Thr Ala Ser Lys Gln Ala Gly 
65                  70                  75                  80  
Ala Ser Leu Gly Thr Asp Ala Lys Gly His Lys Ile Gln Ile Gln Ala 
                85                  90                  95      
Phe Gln Val Thr Gly Asn Glu Ala Ser Ile Ile Ala Tyr Asp Met Ser 
            100                 105                 110         
Thr Gln Tyr Arg Leu Glu His Asn Lys Lys Pro Asp Gly Trp Arg Val 
        115                 120                 125             
Ile Ile Glu Pro Lys Lys Cys Asn Asp Val Lys Val Asp Asp Tyr Gly 
    130                 135                 140                 
Thr Pro Ala Leu Ser Ile Gly Asn Ala Leu Asn Lys Trp Cys Leu Thr 
145                 150                 155                 160 
Lys Leu Thr Leu Thr Gln Glu Asp Ala Gln Thr Leu Asn Ile Gly Asp 
                165                 170                 175     
Thr Val Tyr Phe Pro Thr Lys Ala Val Lys Phe Ser Phe Glu Gly Phe 
            180                 185                 190         
Lys Asp Glu Asp Phe Gly Glu Leu Thr Cys Ser Gly Arg Ser Asp Lys 
        195                 200                 205             
Ile Lys Ile Glu Thr Ser Asp Asn Arg Lys Val Met Leu Ser Phe Thr 
    210                 215                 220                 
Ala Arg Asp Gly Glu Arg Leu Asn Asn Val Arg Leu Asp Glu Gly Ala 
225                 230                 235                 240 
Tyr Glu Leu Asp Glu Leu Phe Leu Ile Gly Asn Thr Val Tyr Lys Phe 
                245                 250                 255     
Arg Gly Thr Glu Asp Ile Thr Asn Asp Val Asn Asn Val Lys Leu Leu 
            260                 265                 270         
Leu Thr Asp Val Ser Asn Ala Asn Asp Phe Glu Val Thr Leu Thr Lys 
        275                 280                 285             
Leu Asn Gly Ser Phe Ser Gly Phe Asn Tyr Thr Tyr Phe Asp Lys Tyr 
    290                 295                 300                 
Ser Thr Ser Met Glu Asn Ser Cys Thr Ser Cys Ser Ile Phe Asn Gly 
305                 310                 315                 320 
Thr Val Gln Gln Ile Pro Gly Lys Met Ala Tyr Phe His Glu Asn Lys 
                325                 330                 335     
Leu Trp Ile Asp Ala Gly Thr Asp Ser Lys Ile Gly Leu Asn Asn Ile 
            340                 345                 350         
Ala Leu Thr Asp Ile Gln Asn Asp Asn Cys Gln Ala Lys 
        355                 360                 365 

<210> 8
<211> 2608
<212> DNA
<213> Artificial Sequence

<220> 
<223> codon-optimized Hamus sequence for expression in human cells
      without His-tag and leader

<400> 8
agcaccggct tggataaatt agataagagt tttgtatatg acgcaaacta caatccgaat      60

gtacatattg tagtaggtga aaaagcagcg gcagcagatg ttgtgggagc aggagatata     120

gcggcaacaa tcggaaatct ggcatataca acaggagcat gcggagcaaa cggaggatca     180

gcaggagaag taaagttagc agtgaagagc tggcaaatga tcggaaaata tgaacaggat     240

ataaaagaca gagttatcgg aacaactaat ttggaagggt cttttttaag ttctaccttt     300

tacagcacag acggacaact acttgcaaac gggacattaa catatactca gggaatgctt     360

aaaaattaca atataggatg tcaaattgac aagacagtat ctaattttcc aatgaaagtt     420

aataactgta atgaattatg ttatctttgt tatgatatat gtcatgagac aaaacatccc     480

gatcatgaga tggaagagtc tataattgta gacggaacaa aagtaaaata ttatgaagat     540

ggattaggag gcgagagcag agcggaatca ttaaagatga agctacacca cggagcacta     600

caatacacag ttaatcttgg tggaattcct gtagcagcta taaccgaagg tgataattta     660

attgatagta gttatagggg aaagatgttg tttatgggtt caaatgacta ttttgttaat     720

aacattgaca agacctacat tgtcttggca aaaggtgaaa aattaatgat aaacaatgca     780

ggtgcaatag aaccgacatt gccagagtta cagggatata aatttaaatt acttagaaca     840

gttcagagta gtggaaaaga tgcaggagtt gtaatggaga ttgaaaaacc agatggaaca     900

actgttcagg caacagcatc aaaacaggca ggtgcttctc ttggaacgga cgcaaagggt     960

cacaagatac aaatacaggc attccaggtt acgggaaacg aagcaagtat aattgcttat    1020

gatatgagca cgcagtacag attagaacat aataaaaaac cagacggatg gagagttata    1080

atagaaccaa aaaaatgtaa tgatgtaaaa gtagatgatt atggaacacc tgcattatca    1140

attggaaatg cattgaataa atggtgttta acaaaattga cattgaccca agaagatgct    1200

caaacactga atataggtga tactgtatat ttcccgacaa aagcagtaaa gttttcattt    1260

gagggcttta aagatgagga tttcggagaa ctgacttgtt caggtagaag tgataaaata    1320

aagatagaaa caagcgataa tcgtaaagta atgttgagct ttactgcaag ggatggagaa    1380

cgattaaata atgtcagatt ggatgaaggt gcttatgaac ttgacgagtt attcctgata    1440

ggaaatacag tatataaatt cagaggaaca gaagatatta ctaacgatgt gaataatgta    1500

aaattattgc tgactgatgt tagcaatgca aatgactttg aagtaacact tacaaaatta    1560

aatggatctt tttcaggatt taattatact tactttgaca aatatagtac aagtatggaa    1620

aattcgtgca cttcatgttc tatatttaat ggaacagtac aacaaatacc aggaaaaatg    1680

gcatatttcc acgaaaataa gttatggatt gatgctggaa ctgatagtaa aattggctta    1740

aataatattg ctttaacaga tattcagaat gataactgcc aggcaaaatt aactacatta    1800

tttgaaaatg gatcaaatct aaatggagaa acaacaaata acaactcgga tgatcaaatt    1860

ttagtatttg aaggttgcgg agaagataga acttatattg acttttacga tacaaatagg    1920

aaagccagag gtaccggtga ttatcagaca agtgttaaaa ttacaggaac agatacctca    1980

ccagtcgcta atacatcatg tttaggttca ggaatagtat gtcataattc aacatcctta    2040

ggatttgaag gtgtcttgaa atacagcgaa gatacaaaat tgtggtcacc aagaggggcg    2100

gacttattca cagtaacaaa ttacggctca gataaacaag tgaaggcagt tgaaatttgc    2160

caccccacaa agaagactta tgtaacttac ttccttggaa aagaaaaaac agaaagtgaa    2220

cagcttggaa caattactgc tgatgatgtt ggaaaattaa agacgattgg atgctgtgaa    2280

gcaactgtaa agtcattcgg attaagtgca ggcaatgcaa caaacacaac cggaacatgt    2340

acgaatatga aaccggtcgg aacattgatg gtgcttgata aaaatgcagt tacaggtaat    2400

ttgattgttg tcggaggacc atcggttaat acattagcag ctagtgcagg tgttacaaaa    2460

gaagaaattg gtgcagatgc aaacaagtat gtgattaaga tggtgggtaa caatacactt    2520

gttgttgcag gatgggaagc agaagataca aataaggcaa ccggtatagt tgttcagtgg    2580

ttactggcaa acgcacataa tgcacatc                                       2608


<210> 9
<211> 2607
<212> DNA
<213> Artificial Sequence

<220> 
<223> codon-optimized for expression in Sf9 cells using baculovirus

<400> 9
tccaccaccg gcctggacaa gctcgacaag tccttcgtgt acgacgctaa ctacaacccc      60

aacgtgcaca tcgtcgtggg cgagaaggct gccgccgctg acgttgtggg tgctggcgat     120

atcgctgcta ccatcggcaa cctggcttac accactggtg cttgcggtgc taacggtggt     180

tccgctggcg aagtgaagct ggctgtgaag tcctggcaga tgatcggaaa gtacgagcag     240

gacatcaagg accgtgtgat cggcactacc aacctggaag gctccttcct gtcctccacc     300

ttctactcca ccgacggcca gctgctcgct aacggcaccc tgacctacac ccagggcatg     360

ctgaagaact acaacatcgg ttgccagatc gacaagaccg tgtccaactt ccccatgaag     420

gtcaacaact gcaacgagct gtgctacctc tgctacgaca tctgccacga gactaagcac     480

cccgaccacg agatggaaga gtccatcatc gtggacggca ccaaggtcaa gtactacgag     540

gacggcctgg gtggcgagtc ccgtgctgag tccctgaaga tgaagttgca ccacggcgct     600

ctgcagtaca ccgtgaacct gggcggtatc cccgtggctg ctatcaccga gggcgacaac     660

ctgatcgact cctcctaccg tggcaagatg ctgttcatgg gttccaacga ctacttcgtg     720

aacaacatcg ataagaccta catcgtgctg gccaagggcg aaaagctgat gatcaacaac     780

gctggtgcta tcgagcccac cctgcccgag ctgcagggtt acaagttcaa gctgctgcgt     840

accgtgcagt cctccggcaa ggacgctggc gtggtcatgg aaatcgagaa gcccgacggt     900

actaccgtcc aggctaccgc ttccaagcag gctggcgctt ccctgggcac cgacgccaag     960

ggtcacaaga tccagatcca ggctttccaa gtgaccggca acgaggcttc tatcatcgct    1020

tacgacatgt ccacccagta ccgtctggaa cacaacaaga agcctgacgg ctggcgcgtg    1080

atcatcgagc ctaagaagtg caacgacgtc aaggtggacg actacggaac ccccgctctg    1140

tccatcggaa acgctctgaa caagtggtgc ctgaccaagc tgaccctgac tcaagaggac    1200

gctcagaccc tgaacatcgg cgacaccgtg tacttcccta ccaaggctgt caagttcagc    1260

ttcgagggct tcaaggacga ggacttcggc gagctgacct gctccggtcg ttccgataag    1320

atcaagatcg agacttccga caaccgcaag gtcatgctgt ccttcaccgc tcgtgacggc    1380

gagcgcctga acaacgtgcg tctggacgag ggcgcctacg agctggacga actgttcctg    1440

atcggcaaca ctgtctacaa gttccgtggc accgaggaca tcaccaacga cgttaacaac    1500

gtgaagctgc tcctgaccga tgtgtccaac gctaacgact tcgaagtgac cctcactaag    1560

ctgaacggtt ccttctccgg cttcaactac acctacttcg ataagtactc gacctccatg    1620

gaaaactctt gcacctcctg ctccatcttc aacggtactg tgcagcagat ccccggaaag    1680

atggcttact tccacgagaa caagctgtgg atcgacgctg gaaccgactc taagatcggc    1740

ctcaacaaca tcgctctgac cgacatccag aacgataact gccaggctaa gctcaccacc    1800

ctgttcgaga acggctccaa cctgaacggc gaaaccacca acaacaactc cgacgaccag    1860

atcctggtgt tcgagggttg cggcgaggac cgtacttaca tcgacttcta cgacactaac    1920

agaaaggctc gcggcaccgg cgactaccag accagcgtga agatcaccgg tactgacacc    1980

tcccccgtcg ctaacacctc ttgcctgggt tccggtatcg tgtgccacaa ctccacctcc    2040

ctgggtttcg aaggtgtcct gaagtactca gaggacacca agctctggtc cccacgcggt    2100

gccgacctgt tcaccgtcac caactacggc tccgacaagc aagtgaaggc cgtcgagatc    2160

tgtcacccca ccaagaagac ctacgttacc tacttcctgg gcaaggaaaa gaccgagtcc    2220

gagcagctgg gaaccatcac cgccgacgac gtgggcaagc tcaagaccat cggatgctgc    2280

gaggccaccg tcaagtcttt cggcctgtct gctggcaacg ctaccaacac taccggaacc    2340

tgcaccaaca tgaagcccgt gggaaccctg atggtgttgg acaagaacgc tgtgaccgga    2400

aacttgatcg tcgtcggtgg tccctccgtg aacaccctgg ctgcctccgc cggtgtcacc    2460

aaggaagaga tcggcgctga cgccaacaag tacgtgatca agatggtcgg aaacaacact    2520

ctggtggtgg ctggatggga ggctgaggat accaacaagg ctactggcat cgtggtgcag    2580

tggctgttgg ctaacgccca caacgct                                        2607


<210> 10
<211> 2650
<212> DNA
<213> Artificial Sequence

<220> 
<223> codon-optimized for expression in Pichia pastoris with His-tag
      and leader sequence

<400> 10
ctcgagaaga gatccaccac gggtcttgat aaactagaca aatcttttgt ctacgacgca      60

aattacaacc ctaacgtgca catcgtcgtg ggtgaaaaag ctgccgctgc tgatgtagtc     120

ggtgcgggtg acattgctgc aacgattggg aatctagcct acactacagg agcttgtggt     180

gctaatggtg gtagcgctgg tgaagtcaag ctggccgtaa agtcttggca aatgattggt     240

aagtatgaac aagacattaa ggatagagtt atcggaacta ccaacctcga aggatcattt     300

ctgtcctcca ccttttactc tactgacggt cagctactcg caaacggaac ccttacctat     360

acgcaaggta tgttgaaaaa ctataacatc ggttgtcaaa ttgacaagac tgtcagcaac     420

ttcccaatga aggtgaacaa ctgcaatgaa ctctgctatc tatgttatga tatttgtcac     480

gaaactaagc acccagacca cgagatggag gaatctatta tcgtggatgg aactaaagtc     540

aagtactatg aggatggtct aggaggtgag tctagagctg agtctctgaa gatgaagctg     600

catcatggtg ccctgcaata taccgttaac ctgggtggta ttccagtcgc agccatcact     660

gagggagaca acctcattga ctcatcttac agaggtaaga tgctattcat gggatcaaac     720

gactacttcg taaacaacat cgataagact tacattgttc tagccaaggg tgagaagctc     780

atgattaaca acgccggtgc aatcgagcct accctccctg aactgcaagg ttacaagttc     840

aagctcctta gaacagtcca gtcctctggt aaggacgctg gtgttgtgat ggagattgaa     900

aagcctgacg gtacaactgt tcaggctacc gcatccaagc aagctggtgc atccctcggc     960

accgacgcta agggtcacaa gattcagatt caagctttcc aagttacggg taatgaggca    1020

tctatcatcg cctacgacat gtctacccaa taccgtctgg agcacaacaa aaagccagac    1080

ggctggagag ttatcatcga gccaaaaaag tgtaacgacg ttaaggtgga tgattacgga    1140

acccctgccc tttcaattgg caatgcactc aacaaatggt gccttaccaa gttaacactc    1200

acccaagagg acgctcagac cctgaacatt ggagacacag tttacttccc aaccaaggcc    1260

gtcaagttct cttttgaggg ttttaaggac gaggacttcg gtgaattgac ttgttcggga    1320

agatccgata agatcaagat tgaaacctct gacaaccgta aggttatgtt atctttcact    1380

gctcgtgacg gtgaaaggct aaacaacgtt agacttgacg agggtgccta cgagcttgat    1440

gaattgttcc ttataggtaa taccgtttac aaattccgtg gtactgagga catcaccaac    1500

gatgtgaata acgtcaaatt gctgttgact gatgtttcta acgccaacga ctttgaggtc    1560

actctcacta agctgaatgg tagtttctcc ggattcaact acacttactt cgacaagtac    1620

tccacctcga tggagaactc ttgcacctcc tgttctattt tcaacggcac agttcaacaa    1680

atccctggaa agatggctta cttccacgaa aacaagctct ggattgacgc aggaactgac    1740

tcaaagatcg gtcttaacaa cattgcactg actgacatcc agaacgacaa ctgtcaggct    1800

aagcttacca ccctgttcga aaacggatct aacctaaacg gtgagactac caacaataac    1860

tcagacgacc aaatactagt ttttgaaggt tgtggagaag atagaaccta cattgatttc    1920

tatgatacca acagaaaggc tagaggtact ggagattacc aaacctctgt gaaaatcacc    1980

gggacggaca catctcctgt tgctaacacc tcttgcctgg gttccggtat tgtctgtcac    2040

aactccactt ccttgggttt cgaaggtgtc cttaagtact ctgaggacac taaactttgg    2100

tccccaagag gtgccgatct atttaccgtc accaactacg gttctgataa gcaagtgaag    2160

gctgttgaaa tctgtcaccc aactaaaaag acttacgtta cttacttcct cggtaaggaa    2220

aagactgagt ctgaacagct cggaactatc actgctgacg acgttggtaa gctaaagact    2280

attggttgct gtgaagctac cgttaaaagt tttggtctgt ctgctggcaa cgctaccaat    2340

actactggta cttgtactaa tatgaagccc gttggtactc ttatggttct tgacaaaaac    2400

gctgtcactg gtaacctcat cgttgttgga ggtccatctg ttaatacact ggcagcttct    2460

gctggcgtca ctaaagagga gatcggagct gacgctaaca agtacgtcat taagatggtt    2520

ggtaacaaca ctctagttgt agctggttgg gaggctgagg atactaataa ggccactgga    2580

attgttgttc aatggctcct agctaacgca cataacgccc accatcatca ccaccactaa    2640

tagcggccgc                                                           2650


<210> 11
<211> 2607
<212> DNA
<213> Artificial Sequence

<220> 
<223> codon-optimized for expression in Pichia pastoris without His-tag
      and leader sequence

<400> 11
tccaccacgg gtcttgataa actagacaaa tcttttgtct acgacgcaaa ttacaaccct      60

aacgtgcaca tcgtcgtggg tgaaaaagct gccgctgctg atgtagtcgg tgcgggtgac     120

attgctgcaa cgattgggaa tctagcctac actacaggag cttgtggtgc taatggtggt     180

agcgctggtg aagtcaagct ggccgtaaag tcttggcaaa tgattggtaa gtatgaacaa     240

gacattaagg atagagttat cggaactacc aacctcgaag gatcatttct gtcctccacc     300

ttttactcta ctgacggtca gctactcgca aacggaaccc ttacctatac gcaaggtatg     360

ttgaaaaact ataacatcgg ttgtcaaatt gacaagactg tcagcaactt cccaatgaag     420

gtgaacaact gcaatgaact ctgctatcta tgttatgata tttgtcacga aactaagcac     480

ccagaccacg agatggagga atctattatc gtggatggaa ctaaagtcaa gtactatgag     540

gatggtctag gaggtgagtc tagagctgag tctctgaaga tgaagctgca tcatggtgcc     600

ctgcaatata ccgttaacct gggtggtatt ccagtcgcag ccatcactga gggagacaac     660

ctcattgact catcttacag aggtaagatg ctattcatgg gatcaaacga ctacttcgta     720

aacaacatcg ataagactta cattgttcta gccaagggtg agaagctcat gattaacaac     780

gccggtgcaa tcgagcctac cctccctgaa ctgcaaggtt acaagttcaa gctccttaga     840

acagtccagt cctctggtaa ggacgctggt gttgtgatgg agattgaaaa gcctgacggt     900

acaactgttc aggctaccgc atccaagcaa gctggtgcat ccctcggcac cgacgctaag     960

ggtcacaaga ttcagattca agctttccaa gttacgggta atgaggcatc tatcatcgcc    1020

tacgacatgt ctacccaata ccgtctggag cacaacaaaa agccagacgg ctggagagtt    1080

atcatcgagc caaaaaagtg taacgacgtt aaggtggatg attacggaac ccctgccctt    1140

tcaattggca atgcactcaa caaatggtgc cttaccaagt taacactcac ccaagaggac    1200

gctcagaccc tgaacattgg agacacagtt tacttcccaa ccaaggccgt caagttctct    1260

tttgagggtt ttaaggacga ggacttcggt gaattgactt gttcgggaag atccgataag    1320

atcaagattg aaacctctga caaccgtaag gttatgttat ctttcactgc tcgtgacggt    1380

gaaaggctaa acaacgttag acttgacgag ggtgcctacg agcttgatga attgttcctt    1440

ataggtaata ccgtttacaa attccgtggt actgaggaca tcaccaacga tgtgaataac    1500

gtcaaattgc tgttgactga tgtttctaac gccaacgact ttgaggtcac tctcactaag    1560

ctgaatggta gtttctccgg attcaactac acttacttcg acaagtactc cacctcgatg    1620

gagaactctt gcacctcctg ttctattttc aacggcacag ttcaacaaat ccctggaaag    1680

atggcttact tccacgaaaa caagctctgg attgacgcag gaactgactc aaagatcggt    1740

cttaacaaca ttgcactgac tgacatccag aacgacaact gtcaggctaa gcttaccacc    1800

ctgttcgaaa acggatctaa cctaaacggt gagactacca acaataactc agacgaccaa    1860

atactagttt ttgaaggttg tggagaagat agaacctaca ttgatttcta tgataccaac    1920

agaaaggcta gaggtactgg agattaccaa acctctgtga aaatcaccgg gacggacaca    1980

tctcctgttg ctaacacctc ttgcctgggt tccggtattg tctgtcacaa ctccacttcc    2040

ttgggtttcg aaggtgtcct taagtactct gaggacacta aactttggtc cccaagaggt    2100

gccgatctat ttaccgtcac caactacggt tctgataagc aagtgaaggc tgttgaaatc    2160

tgtcacccaa ctaaaaagac ttacgttact tacttcctcg gtaaggaaaa gactgagtct    2220

gaacagctcg gaactatcac tgctgacgac gttggtaagc taaagactat tggttgctgt    2280

gaagctaccg ttaaaagttt tggtctgtct gctggcaacg ctaccaatac tactggtact    2340

tgtactaata tgaagcccgt tggtactctt atggttcttg acaaaaacgc tgtcactggt    2400

aacctcatcg ttgttggagg tccatctgtt aatacactgg cagcttctgc tggcgtcact    2460

aaagaggaga tcggagctga cgctaacaag tacgtcatta agatggttgg taacaacact    2520

ctagttgtag ctggttggga ggctgaggat actaataagg ccactggaat tgttgttcaa    2580

tggctcctag ctaacgcaca taacgcc                                        2607


