                         SEQUENCE LISTING

<110>  University of South Florida
 
<120>  Modified UBE3A Gene for a Gene Therapy Approach for Angelman 
       Syndrome

<130>  1372.1055.PRWO

<150>  62/158,269
<151>  2015-05-07

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  2550
<212>  DNA
<213>  Mus musculus

<400>  1
atgaagcgag cagctgcaaa gcatctaata gaacgctact accatcagtt aactgagggc       60

tgtggaaatg aggcctgcac gaatgagttt tgtgcttcct gtccaacttt tcttcgtatg      120

gataacaatg cagcagctat taaagccctt gagctttata aaattaatgc aaaactctgt      180

gatcctcatc cctccaagaa aggagcaagc tcagcttacc ttgagaactc aaaaggtgca      240

tctaacaact cagagataaa aatgaacaag aaggaaggaa aagattttaa agatgtgatt      300

tacctaactg aagagaaagt atatgaaatt tatgaatttt gtagagagag tgaggattat      360

tcccctttaa ttcgtgtaat tggaagaata ttttctagtg ctgaggcact ggttctgagc      420

tttcggaaag tcaaacagca cacaaaggag gaattgaaat ctcttcaaga aaaggatgaa      480

gacaaggatg aagatgaaaa ggaaaaagct gcatgttctg ctgctgctat ggaagaagac      540

tcagaagcat cttcttcaag gatgggtgat agttcacagg gagacaacaa tgtacaaaaa      600

ttaggtcctg atgatgtgac tgtggatatt gatgctatta gaagggtcta cagcagtttg      660

ctcgctaatg aaaaattaga aactgccttc ctgaatgcac ttgtatatct gtcacctaac      720

gtggaatgtg atttgacata tcataatgtg tatactcgag atcctaatta tctcaatttg      780

ttcattattg taatggagaa tagtaatctc cacagtcctg aatatctgga aatggcgttg      840

ccattatttt gcaaagctat gtgtaagcta ccccttgaag ctcaaggaaa actgattagg      900

ctgtggtcta aatacagtgc tgaccagatt cggagaatga tggaaacatt tcagcaactt      960

attacctaca aagtcataag caatgaattt aatagccgaa atctagtgaa tgatgatgat     1020

gccattgttg ctgcttcaaa gtgtttgaaa atggtttact atgcaaatgt agtgggaggg     1080

gatgtggaca caaatcataa tgaggaagat gatgaagaac ccatacctga gtccagcgaa     1140

ttaacacttc aggagcttct gggagatgaa agaagaaata agaaaggtcc tcgagtggat     1200

ccactagaaa ccgaacttgg cgttaaaact ctagactgtc gaaaaccact tatctccttt     1260

gaagaattca ttaatgaacc actgaatgat gttctagaaa tggacaaaga ttataccttt     1320

ttcaaagttg aaacagagaa caaattctct tttatgacat gtccctttat attgaatgct     1380

gtcacaaaga atctgggatt atattatgac aatagaattc gcatgtacag tgaaagaaga     1440

atcactgttc tttacagcct agttcaagga cagcagttga atccgtattt gagactcaaa     1500

gtcagacgtg accatattat agatgatgca ctggtccggc tagagatgat tgctatggaa     1560

aatcctgcag acttgaagaa gcagttgtat gtggaatttg aaggagaaca aggagtaatg     1620

agggaggcgt ttccaaagag ttttttcagt tgggttgtgg aggaaatttt taatccaaat     1680

attggtatgt tcacatatga tgaagctacg aaattatttt ggtttaatcc atcttctttt     1740

gaaactgagg gtcaggttta ctctgattgg catatcctgg gtctggctat ttacaataat     1800

tgtatactgg atgtccattt tcccatggtt gtatacagga agctaatggg gaaaaaagga     1860

acctttcgtg acttgggaga ctctcaccca gttttatatc agagtttaaa ggatttattg     1920

gaatatgaag ggagtgtgga agatgatatg atgatcactt tccagatatc acagacagat     1980

ctttttggta acccaatgat gtatgatcta aaagaaaatg gtgataaaat tccaattaca     2040

aatgaaaaca ggaaggaatt tgtcaatctc tattcagact acattctcaa taaatctgta     2100

gaaaaacaat tcaaggcatt tcgcagaggt tttcatatgg tgactaatga atcgccctta     2160

aaatacttat tcagaccaga agaaattgaa ttgcttatat gtggaagccg gaatctagat     2220

ttccaggcac tagaagaaac tacagagtat gacggtggct atacgaggga atctgttgtg     2280

attagggagt tctgggaaat tgttcattcg tttacagatg aacagaaaag actctttctg     2340

cagtttacaa caggcacaga cagagcacct gttggaggac taggaaaatt gaagatgatt     2400

atagccaaaa atggcccaga cacagaaagg ttacctacat ctcatacttg ctttaatgtc     2460

cttttacttc cggaatattc aagcaaagaa aaacttaaag agagattgtt gaaggccatc     2520

acatatgcca aaggatttgg catgctgtaa                                      2550


<210>  2
<211>  78
<212>  DNA
<213>  Mus musculus

<400>  2
atggccctgt tggtgcactt cctacccctg ctggccctgc ttgccctctg ggagcccaaa       60

cccacccagg cttttgtc                                                     78


<210>  3
<211>  26
<212>  PRT
<213>  Mus musculus

<400>  3

Met Ala Leu Leu Val His Phe Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Glu Pro Lys Pro Thr Gln Ala Phe Val 
            20                  25      


<210>  4
<211>  33
<212>  DNA
<213>  Human immunodefiency virus

<400>  4
tacggcagaa agaagaggag gcagagaagg aga                                    33


<210>  5
<211>  11
<212>  PRT
<213>  Human immunodeficiency virus

<400>  5

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  6
<211>  10893
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (122)..(122)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (340)..(340)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1145)..(1145)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1180)..(1180)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1257)..(1257)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (5410)..(5410)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (7624)..(7624)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (7644)..(7644)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (7647)..(7647)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (7741)..(7741)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (7836)..(7836)
<223>  n is a, c, g, or t

<400>  6
ggagtagttt actgagccac taatctaaag tttaatactg tgagtgaata ccagtgagta       60

cctttgttaa tgtggataac caatacttgg ctataggaag ttttttagtt gtgtgtttta      120

tnacacgtat ttgactttgt gaataattat ggcttataat ggcttgtctg ttggtatcta      180

tgtatagcgt ttacagtttc ctttaaaaaa catgcattga gttttttaat agtccaaccc      240

ttaaaataaa tgtgttgtat ggccacctga tctgaccact ttctttcatg ttgacatctt      300

taattttaaa actgttttat ttagtgctta aatcttgttn acaaaattgt cttcctaagt      360

aatatgtcta cctttttttt tggaatatgg aatattttgc taactgtttc tcaattgcat      420

tttacagatc aggagaacct cagtctgacg acattgaagc tagccgaatg taagtgtaac      480

ttggttgaga ctgtggttct tattttgagt tgccctagac tgctttaaat tacgtcacat      540

tatttggaaa taatttctgg ttaaaagaaa ggaatcattt agcagtaaat gggagatagg      600

aacataccta ctttttttcc tatcagataa ctctaaacct cggtaacagt ttactaggtt      660

tctactacta gatagataaa tgcacacgcc taaattctta gtctttttgc ttccctggta      720

gcagttgtag ggaaataggg aggttgagga aagagtttaa cagtctcaac gcctaccata      780

tttaaggcat caagtactat gttatagata cagagatgcg taataattag ttttcaccct      840

acagaaattt atattatact caagagtgaa agatgcagaa gcaaataatt tcagtcactg      900

aggtagaatg gtatccaaaa tacaatagta acatgaagga gtactggagt accaggtatg      960

caataggaat ctagtgtaga tggcagggaa gtaagagtgg ccaggaaatg ctaagttcag     1020

tcttgaaatg tgactgggaa tcaggcagct atcaactata agtcaaatgt ttacaagctg     1080

ttaaaaatga aatactgatt atgtaaaaga aaaccggatt gatgctttaa atagactcat     1140

tttcntaatg ctaattttta aaatgataga atcctacaan tcttagctgt aaaccttgtg     1200

atttttcagc tgttgtacta aacaacttaa gcacatatac catcagacaa gcccccntcc     1260

ccccttttaa accaaaggaa tgtatactct gttaatacag tcagtaagca ttgacattct     1320

ttatcataat atcctagaaa atatttatta actatttcac tagtcaggag ttgtggtaaa     1380

tagtgcatct ccattttcta cttctcatct tcatacacag gttaatcact tcagtgcttg     1440

actaactttt gccttgatga tatgttgagc tttgtacttg agagctgtac taatcactgt     1500

gcttattgtt tgaatgtttg gtacaggaag cgagcagctg caaagcatct aatagaacgc     1560

tactaccacc agttaactga gggctgtgga aatgaagcct gcacgaatga gttttgtgct     1620

tcctgtccaa cttttcttcg tatggataat aatgcagcag ctattaaagc cctcgagctt     1680

tataagatta atgcaaaact ctgtgatcct catccctcca agaaaggagc aagctcagct     1740

taccttgaga actcgaaagg tgcccccaac aactcctgct ctgagataaa aatgaacaag     1800

aaaggcgcta gaattgattt taaaggtaag atgttttatt ttcaattgag aattgttgcc     1860

tgaaaaccat gtgggagatt taaatgtatt agtttttatt tgttttttct tctgtgacat     1920

aaagacattt tgatatcgta gaaccaattt tttattgtgg taacggacag gaataataac     1980

tacattttac aggtctaatc attgctaatt agaagcagat catatgccaa aagttcattt     2040

gttaatagat tgatttgaac tttttaaaat tcttaggaaa aatgtattaa gtggtagtga     2100

atctccaaaa ctatttaaga gctgtattat gattaatcag tacatgacat attggttcat     2160

atttataatt aaagctatac attaatagat atcttgatta taaagaaagt ttaaactcat     2220

gatcttatta agagttatac attgttgaaa gaatgtaaaa gcatgggtga ggtcattggt     2280

ataggtaggt agttcattga aaaaaatagg taagcattaa attttgtttg ctgaatctaa     2340

gtattagata ctttaagagt tgtatatcat aaatgatatt gagcctagaa tgtttggctg     2400

ttttactttt agaacttttt gcaacagagt aaacatacat attatgaaaa taaatgttct     2460

cttttttcct ctgattttct agatgtgact tacttaacag aagagaaggt atatgaaatt     2520

cttgaattat gtagagaaag agaggattat tcccctttaa tccgtgttat tggaagagtt     2580

ttttctagtg ctgaggcatt ggtacagagc ttccggaaag ttaaacaaca caccaaggaa     2640

gaactgaaat ctcttcaagc aaaagatgaa gacaaagatg aagatgaaaa ggaaaaagct     2700

gcatgttctg ctgctgctat ggaagaagac tcagaagcat cttcctcaag gataggtgat     2760

agctcacagg gagacaacaa tttgcaaaaa ttaggccctg atgatgtgtc tgtggatatt     2820

gatgccatta gaagggtcta caccagattg ctctctaatg aaaaaattga aactgccttt     2880

ctcaatgcac ttgtatattt gtcacctaac gtggaatgtg acttgacgta tcacaatgta     2940

tactctcgag atcctaatta tctgaatttg ttcattatcg taatggagaa tagaaatctc     3000

cacagtcctg aatatctgga aatggctttg ccattatttt gcaaagcgat gagcaagcta     3060

ccccttgcag cccaaggaaa actgatcaga ctgtggtcta aatacaatgc agaccagatt     3120

cggagaatga tggagacatt tcagcaactt attacttata aagtcataag caatgaattt     3180

aacagtcgaa atctagtgaa tgatgatgat gccattgttg ctgcttcgaa gtgcttgaaa     3240

atggtttact atgcaaatgt agtgggaggg gaagtggaca caaatcacaa tgaagaagat     3300

gatgaagagc ccatccctga gtccagcgag ctgacacttc aggaactttt gggagaagaa     3360

agaagaaaca agaaaggtcc tcgagtggac cccctggaaa ctgaacttgg tgttaaaacc     3420

ctggattgtc gaaaaccact tatccctttt gaagagttta ttaatgaacc actgaatgag     3480

gttctagaaa tggataaaga ttatactttt ttcaaagtag aaacagagaa caaattctct     3540

tttatgacat gtccctttat attgaatgct gtcacaaaga atttgggatt atattatgac     3600

aatagaattc gcatgtacag tgaacgaaga atcactgttc tctacagctt agttcaagga     3660

cagcagttga atccatattt gagactcaaa gttagacgtg accatatcat agatgatgca     3720

cttgtccggg taagttgggc tgctagatta aaaacctaat aatggggata tcatgataca     3780

gttcagtgaa ttcattttaa aagtgactga aaaaaatgat accatatagc ataggaacac     3840

atggacattt ctgatcttat ataagtatta tacttttgtt gttcctgtgc aagtttatag     3900

atgtgttcta caaagtatcg gttgtattat ataatggtca tgctatcttt gaaaaagaat     3960

gggttttcta aatcttgaaa actaaatcca aagtttcttt cattcagaag agaatagagt     4020

gttggacaaa gaccagaaca agagaaatgt ggagataccc aataataagt gtggatgtgc     4080

agtcttgaac tgggagtaat ggtacagtaa aaccatacca taaaattata ggtagtgtcc     4140

aaaaaattcc atcgtgtaaa attcagagtt gcattattgt ggacttgaag aagcagttgt     4200

atgtgggacg gtatcgataa gcttgatatc gaattcctgc agcccggggg atccactagt     4260

gtggtaatta atactaagtc ttactgtgag agaccataaa ctgctttagt attcagtgta     4320

tttttcttaa ttgaaatatt taacttatga cttagtagat actaagactt aacccttgag     4380

tttctattct aataaaggac tactaatgaa caattttgag gttagacctc tactccattg     4440

tttttgctga aatgatttag ctgcttttcc atgtcctgtg tagtccagac ttaacacaca     4500

agtaataaaa tcttaattaa ttgtatgtta atttcataac aaatcagtaa agttagcttt     4560

ttactatgct agtgtctgtt ttgtgtctgt ctttttgatt atctttaaga ctgaatcttt     4620

gtcttcactg gctttttatc agtttgcttt ctgtttccat ttacatacaa aaagtcaaaa     4680

atttgtattt gtttcctaat cctactcctt gtttttattt tgtttttttc ctgatactag     4740

caatcatctt cttttcatgt ttatcttttc aatcactagc tagagatgat cgctatggaa     4800

aatcctgcag acttgaagaa gcagttgtat gtggaatttg aaggagaaca aggagttgat     4860

gagggaggtg tttccaaaga attttttcag ctggttgtgg aggaaatctt caatccagat     4920

attggtaaat acattagtaa tgtgattatg gtgtcgtatc atcttttgag ttagttattt     4980

gtttatctta ctttgtaaat attttcagct atgaagagca gcaaaagaag gatttggtat     5040

ggattaccca gaatcacaca tcatgactga atttgtaggt tttaggaact gatttgtatc     5100

actaatttat tcaaattctt ttatttctta gaaggaatat tctaatgaag gaaattatct     5160

ctttggtaaa ctgaattgaa agcactttag aatggtatat tggaacagtt ggagggattt     5220

ctttgctttt tgttgtctaa aaccatcatc aaactcacgg ttttcctgac ctgtgaactt     5280

caaagaacaa tggtttgaag agtattgaga gactgtctca caagtatgtc atgctcaaag     5340

ttcagaaaca ctagctgata tcacattaat taggtttatt tgctataaga tttcttgggg     5400

cttaatatan gtagtgttcc cccaaacttt ttgaactcca gaactctttt ctgccctaac     5460

agtagctact caggagctga ggcaggagaa ttgtttgaac ctaggaggca gaggttgcag     5520

tgagctgaga tcgtgccact ccagcccacc cctgggtaac agagcgagac tccatctcaa     5580

agaaaaaaat gaaaaattgt tttcaaaaat agtacgtgtg gtacagatat aagtaattat     5640

atttttataa atgaaacact ttggaaatgt agccattttt tgttttttta tgtttatttt     5700

tcagctatgg gtggataaag catgaatata acttttctta tgtgttagta gaaaattaga     5760

aagcttgaat ttaattaacg tatttttcta cccgatgcca ccaaattact tactacttta     5820

ttcctttggc ttcataaaat tacatatcac cattcacccc aatttatagc agatatatgt     5880

ggacattgtt ttctcaagtg ctaatataat agaaatcaat gttgcatgcc taattacata     5940

tattttaaat gttttatatg cataattatt ttaagtttat atttgtatta ttcatcagtc     6000

cttaataaaa tacaaaagta atgtattttt aaaaatcatt tcttataggt atgttcacat     6060

acgatgaatc tacaaaattg ttttggttta atccatcttc ttttgaaact gagggtcagt     6120

ttactctgat tggcatagta ctgggtctgg ctatttacaa taactgtata ctggatgtac     6180

attttcccat ggttgtctac aggaagctaa tggggaaaaa aggaactttt cgtgacttgg     6240

gagactctca cccagtaagt tctttgtcat ttttttaatt cagtctctta gattttattt     6300

aaatgcaaaa atttaattta tgtcaaaatt ttaaagtttt tgtttagaat ctttgttgat     6360

actcttatca ataagataaa aatgttttaa tctgaccgaa gtaccagaaa cacttaaaaa     6420

ctcaaagggg gacattttta tatattgctg tcagcacgaa gctttcgtaa gattgatttc     6480

atagagaagt gtttctaaac attttgtttg tgttttagtg aaatcttaag agataggtaa     6540

aaatcagagt agccctggct aagggtcttg gtagttacaa cgagtgtgcc tgctcctacc     6600

acccccaccc ccaccttgag acaccacaga atttctcata gagcacagtg tgaattctat     6660

tgctaaattg gtggtatggg gtttctcagc agagaatggg acatcacagt gactgacaat     6720

ctttctttta taggttggaa actatttggg ggactggagg gatactgtct acacttttta     6780

caatttttat tgataagatt tttgttgtct tctaagaaga gtgatataaa ttatttgttg     6840

tattttgtag ttctatggtg gcctcaattt accatttctg gttgctaggt tctatatcag     6900

agtttaaaag atttattgga gtatgaaggg aatgtggaag atgacatgat gatcactttc     6960

cagatatcac agacagatct ttttggtaac ccaatgatgt atgatctaaa ggaaaatggt     7020

gataaaattc caattacaaa tgaaaacagg aaggtaataa atgtttttat gtcacatttt     7080

gtctcttcat taacactttc aaagcatgta tgcttataat ttttaaagaa gtatctaata     7140

tagtctgtac aaaaaaaaaa caagtaacta agtttatgta aatgctagag tccacttttc     7200

taaatcttgg atataagttg gtatgaaagc acacagttgg gcactaaagc cccttttaga     7260

gaaagaggac atgaagcagg agatagttaa tagctaagtg tggttgtagt ataaagcaag     7320

aagcagggtg tttcttgtat taagctgtaa gcaggaacct catgattaag gtctttatca     7380

cagaacaaat aaaaattaca tttaatttac acatgtatat cctgtttgtg ataaaaatac     7440

atttctgaaa agtatacttt acgtcagatt tgggttctat tgactaaaat gtgttcatcg     7500

ggaatgggaa taacccagaa cataacaagc aaaaaattat gacaaatata tagtatacct     7560

ttaagaaaca tgtttatatt gatataattt tttgattaaa tattatacac actaagggta     7620

caangcacat tttcctttta tganttngat acagtagttt atgtgtcagt cagatacttc     7680

cacatttttg ctgaactgga tacagtaagc agcttaccaa atattctatg gtagaaaact     7740

nggacttcct ggtttgctta aatcaaatat attgtactct cttaaaacgg ttggcattta     7800

taaatagatg gatacatggt ttaaatgtgt ctgttnacat acctagttga gagaacctaa     7860

agaattttct gcgtctccag catttatatt cagttctgtt taatacatta tcgaaattga     7920

catttataag tatgacagtt ttgtgtatat ggccttttca tagcttaata ttggctgtaa     7980

cagagaattg tgaaattgta agaagtagtt ttctttgtag gtgtaaaatt gaatttttaa     8040

gaatattctt gacagtttta tgtatatggc cttttcatag cttaatattg gctataacag     8100

agaattgtga aattgttaag aagtaggtgt aaaattgaat ttttaagaat attcttgaat     8160

gtttttttct tggaaaaatt aaaaagctat gcagcccaat aacttgtgtt ttgtttgcat     8220

agcatattat aagaagttct tgtgattaat gttttctaca ggaatttgtc aatctttatt     8280

ctgactacat tctcaataaa tcagtagaaa aacagttcaa ggcttttcgg agaggttttc     8340

atatggtgac caatgaatct cccttaaagt acttattcag accagaagaa attgaattgc     8400

ttatatgtgg aagccgggta agaaagcagg tgtctgcaaa aagtcatgta tcgatttatt     8460

gtttgtaatg atacagtagt atagcagata actaagacat attttcttga atttgcagaa     8520

tctagatttc caagcactag aagaaactac agaatatgac ggtggctata ccagggactc     8580

tgttctgatt aggtgaggta cttagttctt cagaggaaga tttgattcac caaaggggtg     8640

tgtgattttg cttcagacct ttatctctag gtactaattc ccaaataagc aaactcacaa     8700

attgtcatct atatacttag atttgtattt gtaatataat caccattttt cagagctaat     8760

cttgtgattt atttcatgaa tgaagtgttg ttatatataa gtctcatgta atctcctgca     8820

tttggcgtat ggattatcta gtattcctca ctggttagag tatgcttact gctggttaga     8880

agataattaa aataaggcta ccatgtctgc aatttttcct ttcttttgaa ctctgcattt     8940

gtgaactgtt acatggcttc ccaggatcaa gcactttttg agtgaaatgg tagtctttta     9000

tttaattctt aagataatat gtccagatac atactagtat ttccatttta caccctaaaa     9060

aactaagccc tgaattctca cagaaagatg tagaggttcc cagttctatc tgcttttaaa     9120

caaatgccct tactactcta ctgtctactt ctgtgtacta catcatcgta tgtagttgtt     9180

tgcatttggg ccagttggtt ggggcagggg tctttttttc ttttgtccct taatctgtat     9240

cactttttcc tcccaaagtt gagttaaagg atgagtagac caggagaata aaggagaaag     9300

gataaataaa atatataccc aaaggcacct ggagttaatt tttccaaata ttcatttcag     9360

tctttttcaa ttcataggat tttgtctttt gctcattact gactgcataa tgtgattata     9420

ccatagttta aatagtcact tcctgttact acacacttgg gttttctcaa ttttttacta     9480

ttgtagtact aatattttac tatattgtaa tctaatccaa atttttacgt attcagagct     9540

gttcaggata aatttgcttg gaaattttta aatcaccaga agtgatacta tcctgataat     9600

taacttccaa gttgtctctt aatatagttt taatgcaaat cataagctta tgttagtacc     9660

agtcataatg aatgccaaac tgaaaccagt attgtatttt ttctcattag ggagttctgg     9720

gaaatcgttc attcatttac agatgaacag aaaagactct tcttgcagtt tacaacgggc     9780

acagacagag cacctgtggg aggactagga aaattaaaga tgattatagc caaaaatggc     9840

ccagacacag aaaggtaggt aattattaac ttgtgactgt atacctaccg aaaaccttgc     9900

attcctcgtc acatacatat gaactgtctt tatagtttct gagcacattc gtgattttat     9960

atacaaatcc ccaaatcata ttagacaatt gagaaaatac tttgctgtca ttgtgtgagg    10020

aaacttttaa gaaattgccc tagttaaaaa ttattatggg gctcacattg gtttggaatc    10080

aaattagtgt gattcattta cttttttgat tcccagcttg ttaattgaaa gccatataac    10140

atgatcatct atttagaatg gttacattga ggctcggaag attatcattt gattgtgcta    10200

gaatcctgtt atcaaatcat tttcttagtc atattgccag cagtgtttct aataagcatt    10260

taagagcaca cactttgcag tcttgtaaaa caggtttgag tattttctcc accttagagg    10320

aagttacttg acttctcagt gacctaacct ctaaagtgca tttactgatg tcctctctgt    10380

ggttttgttg tggaaagatt tagttaaatg aactgtaaga attcagtacc taaaatggta    10440

tctgttatgt agtaaaaact caatggatac agtatcttat catcgtcact agctttgagt    10500

aatttatagg ataaaggcaa cttggtagtt acacaacaaa aagtttatga tttgcattaa    10560

tgtatagttt gcattgcaga ccgtctcaac tatatacaat ctaaaaatag gagcatttaa    10620

ttctaagtgt atttcccatg acttacagtt ttcctgtttt tttccccttt tctctattta    10680

ggttacctac atctcatact tgctttaatg tgcttttact tccggaatac tcaagcaaag    10740

aaaaacttaa agagagattg ttgaaggcca tcacgtatgc caaaggattt ggcatgctgt    10800

aaaacaaaac aaaacaaaat aaaacaaaaa aaaggaagga aaaaaaaaga aaaaatttaa    10860

aaaattttaa aaatataacg agggataaat ttt                                 10893


<210>  7
<211>  852
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Lys Arg Ala Ala Ala Lys His Leu Ile Glu Arg Tyr Tyr His Gln 
1               5                   10                  15      


Leu Thr Glu Gly Cys Gly Asn Glu Ala Cys Thr Asn Glu Phe Cys Ala 
            20                  25                  30          


Ser Cys Pro Thr Phe Leu Arg Met Asp Asn Asn Ala Ala Ala Ile Lys 
        35                  40                  45              


Ala Leu Glu Leu Tyr Lys Ile Asn Ala Lys Leu Cys Asp Pro His Pro 
    50                  55                  60                  


Ser Lys Lys Gly Ala Ser Ser Ala Tyr Leu Glu Asn Ser Lys Gly Ala 
65                  70                  75                  80  


Pro Asn Asn Ser Cys Ser Glu Ile Lys Met Asn Lys Lys Gly Ala Arg 
                85                  90                  95      


Ile Asp Phe Lys Asp Val Thr Tyr Leu Thr Glu Glu Lys Val Tyr Glu 
            100                 105                 110         


Ile Leu Glu Leu Cys Arg Glu Arg Glu Asp Tyr Ser Pro Leu Ile Arg 
        115                 120                 125             


Val Ile Gly Arg Val Phe Ser Ser Ala Glu Ala Leu Val Gln Ser Phe 
    130                 135                 140                 


Arg Lys Val Lys Gln His Thr Lys Glu Glu Leu Lys Ser Leu Gln Ala 
145                 150                 155                 160 


Lys Asp Glu Asp Lys Asp Glu Asp Glu Lys Glu Lys Ala Ala Cys Ser 
                165                 170                 175     


Ala Ala Ala Met Glu Glu Asp Ser Glu Ala Ser Ser Ser Arg Ile Gly 
            180                 185                 190         


Asp Ser Ser Gln Gly Asp Asn Asn Leu Gln Lys Leu Gly Pro Asp Asp 
        195                 200                 205             


Val Ser Val Asp Ile Asp Ala Ile Arg Arg Val Tyr Thr Arg Leu Leu 
    210                 215                 220                 


Ser Asn Glu Lys Ile Glu Thr Ala Phe Leu Asn Ala Leu Val Tyr Leu 
225                 230                 235                 240 


Ser Pro Asn Val Glu Cys Asp Leu Thr Tyr His Asn Val Tyr Ser Arg 
                245                 250                 255     


Asp Pro Asn Tyr Leu Asn Leu Phe Ile Ile Val Met Glu Asn Arg Asn 
            260                 265                 270         


Leu His Ser Pro Glu Tyr Leu Glu Met Ala Leu Pro Leu Phe Cys Lys 
        275                 280                 285             


Ala Met Ser Lys Leu Pro Leu Ala Ala Gln Gly Lys Leu Ile Arg Leu 
    290                 295                 300                 


Trp Ser Lys Tyr Asn Ala Asp Gln Ile Arg Arg Met Met Glu Thr Phe 
305                 310                 315                 320 


Gln Gln Leu Ile Thr Tyr Lys Val Ile Ser Asn Glu Phe Asn Ser Arg 
                325                 330                 335     


Asn Leu Val Asn Asp Asp Asp Ala Ile Val Ala Ala Ser Lys Cys Leu 
            340                 345                 350         


Lys Met Val Tyr Tyr Ala Asn Val Val Gly Gly Glu Val Asp Thr Asn 
        355                 360                 365             


His Asn Glu Glu Asp Asp Glu Glu Pro Ile Pro Glu Ser Ser Glu Leu 
    370                 375                 380                 


Thr Leu Gln Glu Leu Leu Gly Glu Glu Arg Arg Asn Lys Lys Gly Pro 
385                 390                 395                 400 


Arg Val Asp Pro Leu Glu Thr Glu Leu Gly Val Lys Thr Leu Asp Cys 
                405                 410                 415     


Arg Lys Pro Leu Ile Pro Phe Glu Glu Phe Ile Asn Glu Pro Leu Asn 
            420                 425                 430         


Glu Val Leu Glu Met Asp Lys Asp Tyr Thr Phe Phe Lys Val Glu Thr 
        435                 440                 445             


Glu Asn Lys Phe Ser Phe Met Thr Cys Pro Phe Ile Leu Asn Ala Val 
    450                 455                 460                 


Thr Lys Asn Leu Gly Leu Tyr Tyr Asp Asn Arg Ile Arg Met Tyr Ser 
465                 470                 475                 480 


Glu Arg Arg Ile Thr Val Leu Tyr Ser Leu Val Gln Gly Gln Gln Leu 
                485                 490                 495     


Asn Pro Tyr Leu Arg Leu Lys Val Arg Arg Asp His Ile Ile Asp Asp 
            500                 505                 510         


Ala Leu Val Arg Leu Glu Met Ile Ala Met Glu Asn Pro Ala Asp Leu 
        515                 520                 525             


Lys Lys Gln Leu Tyr Val Glu Phe Glu Gly Glu Gln Gly Val Asp Glu 
    530                 535                 540                 


Gly Gly Val Ser Lys Glu Phe Phe Gln Leu Val Val Glu Glu Ile Phe 
545                 550                 555                 560 


Asn Pro Asp Ile Gly Met Phe Thr Tyr Asp Glu Ser Thr Lys Leu Phe 
                565                 570                 575     


Trp Phe Asn Pro Ser Ser Phe Glu Thr Glu Gly Gln Phe Thr Leu Ile 
            580                 585                 590         


Gly Ile Val Leu Gly Leu Ala Ile Tyr Asn Asn Cys Ile Leu Asp Val 
        595                 600                 605             


His Phe Pro Met Val Val Tyr Arg Lys Leu Met Gly Lys Lys Gly Thr 
    610                 615                 620                 


Phe Arg Asp Leu Gly Asp Ser His Pro Val Leu Tyr Gln Ser Leu Lys 
625                 630                 635                 640 


Asp Leu Leu Glu Tyr Glu Gly Asn Val Glu Asp Asp Met Met Ile Thr 
                645                 650                 655     


Phe Gln Ile Ser Gln Thr Asp Leu Phe Gly Asn Pro Met Met Tyr Asp 
            660                 665                 670         


Leu Lys Glu Asn Gly Asp Lys Ile Pro Ile Thr Asn Glu Asn Arg Lys 
        675                 680                 685             


Glu Phe Val Asn Leu Tyr Ser Asp Tyr Ile Leu Asn Lys Ser Val Glu 
    690                 695                 700                 


Lys Gln Phe Lys Ala Phe Arg Arg Gly Phe His Met Val Thr Asn Glu 
705                 710                 715                 720 


Ser Pro Leu Lys Tyr Leu Phe Arg Pro Glu Glu Ile Glu Leu Leu Ile 
                725                 730                 735     


Cys Gly Ser Arg Asn Leu Asp Phe Gln Ala Leu Glu Glu Thr Thr Glu 
            740                 745                 750         


Tyr Asp Gly Gly Tyr Thr Arg Asp Ser Val Leu Ile Arg Glu Phe Trp 
        755                 760                 765             


Glu Ile Val His Ser Phe Thr Asp Glu Gln Lys Arg Leu Phe Leu Gln 
    770                 775                 780                 


Phe Thr Thr Gly Thr Asp Arg Ala Pro Val Gly Gly Leu Gly Lys Leu 
785                 790                 795                 800 


Lys Met Ile Ile Ala Lys Asn Gly Pro Asp Thr Glu Arg Leu Pro Thr 
                805                 810                 815     


Ser His Thr Cys Phe Asn Val Leu Leu Leu Pro Glu Tyr Ser Ser Lys 
            820                 825                 830         


Glu Lys Leu Lys Glu Arg Leu Leu Lys Ala Ile Thr Tyr Ala Lys Gly 
        835                 840                 845             


Phe Gly Met Leu 
    850         


<210>  8
<211>  57
<212>  DNA
<213>  Homo sapiens

<400>  8
atgaagttat gggatgtcgt ggctgtctgc ctggtgctgc tccacaccgc gtccgcc          57


<210>  9
<211>  72
<212>  DNA
<213>  Homo sapiens

<400>  9
atggccctgt ggatgcgcct cctgcccctg ctggcgctgc tggccctctg gggacctgac       60

ccagccgcag cc                                                           72


<210>  10
<211>  60
<212>  DNA
<213>  Homo sapiens

<400>  10
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60


<210>  11
<211>  11
<212>  DNA
<213>  Human immunodefiency virus

<400>  11
yarkaarqar a                                                            11


<210>  12
<211>  2767
<212>  DNA
<213>  Homo sapiens

<400>  12
acagtatgac atctgatgct ggagggtcgc actttcacaa atgagtcagc tggtacatgg       60

ggttatcatc aatttttagc tcttctgtct gggagataca agtttggaag caatcttggg      120

gtacttaccc acaaggctgg tggagaccag atcaggagaa cctcagtctg acgacattga      180

agctagccga atgaagcgag cagctgcaaa gcatctaata gaacgctact accaccagtt      240

aactgagggc tgtggaaatg aagcctgcac gaatgagttt tgtgcttcct gtccaacttt      300

tcttcgtatg gataataatg cagcagctat taaagccctc gagctttata agattaatgc      360

aaaactctgt gatcctcatc cctccaagaa aggagcaagc tcagcttacc ttgagaactc      420

gaaaggtgcc cccaacaact cctgctctga gataaaaatg aacaagaaag gcgctagaat      480

tgattttaaa gatgtgactt acttaacaga agagaaggta tatgaaattc ttgaattatg      540

tagagaaaga gaggattatt cccctttaat ccgtgttatt ggaagagttt tttctagtgc      600

tgaggcattg gtacagagct tccggaaagt taaacaacac accaaggaag aactgaaatc      660

tcttcaagca aaagatgaag acaaagatga ggatgaaaag gaaaaagctg catgttctgc      720

tgctgctatg gaagaagact cagaagcatc ttcctcaagg ataggtgata gctcacaggg      780

agacaacaat ttgcaaaaat taggccctga tgatgtgtct gtggatattg atgccattag      840

aagggtctac accagattgc tctctaatga aaaaattgaa actgcctttc tcaatgcact      900

tgtatatttg tcacctaacg tggaatgtga cttgacgtat cacaatgtat actctcgaga      960

tcctaattat ctgaatttgt tcattatcgt aatggagaat agaaatctcc acagtcctga     1020

atatctggaa atggctttgc cattattttg caaagcgatg agcaagctac cccttgcagc     1080

ccaaggaaaa ctgatcagac tgtggtctaa atacaatgca gaccagattc ggagaatgat     1140

ggagacattt cagcaactta ttacttataa agtcataagc aatgaattta acagtcgaaa     1200

tctagtgaat gatgatgatg ccattgttgc tgcttcgaag tgcttgaaaa tggtttacta     1260

tgcaaatgta gtgggagggg aagtggacac aaatcacaat gaagaagatg atgaagagcc     1320

catccctgag tccagcgagc tgacacttca ggaacttttg ggagaagaaa gaagaaacaa     1380

gaaaggtcct cgagtggacc ccctggaaac tgaacttggt gttaaaaccc tggattgtcg     1440

aaaaccactt atcccttttg aagagtttat taatgaacca ctgaatgagg ttctagaaat     1500

ggataaagat tatacttttt tcaaagtaga aacagagaac aaattctctt ttatgacatg     1560

tccctttata ttgaatgctg tcacaaagaa tttgggatta tattatgaca atagaattcg     1620

catgtacagt gaacgaagaa tcactgttct ctacagctta gttcaaggac agcagttgaa     1680

tccatatttg agactcaaag ttagacgtga ccatatcata gatgatgcac ttgtccggct     1740

agagatgatc gctatggaaa atcctgcaga cttgaagaag cagttgtatg tggaatttga     1800

aggagaacaa ggagttgatg agggaggtgt ttccaaagaa ttttttcagc tggttgtgga     1860

ggaaatcttc aatccagata ttggtatgtt cacatacgat gaatctacaa aattgttttg     1920

gtttaatcca tcttcttttg aaactgaggg tcagtttact ctgattggca tagtactggg     1980

tctggctatt tacaataact gtatactgga tgtacatttt cccatggttg tctacaggaa     2040

gctaatgggg aaaaaaggaa cttttcgtga cttgggagac tctcacccag ttctatatca     2100

gagtttaaaa gatttattgg agtatgaagg gaatgtggaa gatgacatga tgatcacttt     2160

ccagatatca cagacagatc tttttggtaa cccaatgatg tatgatctaa aggaaaatgg     2220

tgataaaatt ccaattacaa atgaaaacag gaaggaattt gtcaatcttt attctgacta     2280

cattctcaat aaatcagtag aaaaacagtt caaggctttt cggagaggtt ttcatatggt     2340

gaccaatgaa tctcccttaa agtacttatt cagaccagaa gaaattgaat tgcttatatg     2400

tggaagccgg aatctagatt tccaagcact agaagaaact acagaatatg acggtggcta     2460

taccagggac tctgttctga ttagggagtt ctgggaaatc gttcattcat ttacagatga     2520

acagaaaaga ctcttcttgc agtttacaac gggcacagac agagcacctg tgggaggact     2580

aggaaaatta aagatgatta tagccaaaaa tggcccagac acagaaaggt tacctacatc     2640

tcatacttgc tttaatgtgc ttttacttcc ggaatactca agcaaagaaa aacttaaaga     2700

gagattgttg aaggccatca cgtatgccaa aggatttggc atgctgtaaa acaaaacaaa     2760

acaaaat                                                               2767


<210>  13
<211>  5276
<212>  DNA
<213>  Homo sapiens

<400>  13
agccagtcct cccgtcttgc gccgcggccg cgagatccgt gtgtctccca agatggtggc       60

gctgggctcg gggtgactac aggagacgac ggggcctttt cccttcgcca ggacccgaca      120

caccaggctt cgctcgctcg cgcacccctc cgccgcgtag ccatccgcca gcgcgggcgc      180

ccgccatccg ccgcctactt acgcttcacc tctgccgacc cggcgcgctc ggctgcgggc      240

ggcggcgcct ccttcggctc ctcctcggaa tagctcgcgg cctgtagccc ctggcaggag      300

ggcccctcag ccccccggtg tggacaggca gcggcggctg gcgacgaacg ccgggatttc      360

ggcggccccg gcgctccctt tcccggcctc gttttccgga taaggaagcg cgggtcccgc      420

atgagccccg gcggtggcgg cagcgaaaga gaacgaggcg gtggcgggcg gaggcggcgg      480

gcgagggcga ctacgaccag tgaggcggcc gccgcagccc aggcgcgggg gcgacgacag      540

gttaaaaatc tgtaagagcc tgattttaga attcaccagc tcctcagaag tttggcgaaa      600

tatgagttat taagcctacg ctcagatcaa ggtagcagct agactggtgt gacaacctgt      660

ttttaatcag tgactcaaag ctgtgatcac cctgatgtca ccgaatggcc acagcttgta      720

aaagagagtt acagtggagg taaaaggagt ggcttgcagg atggagaagc tgcaccagtg      780

ttattggaaa tcaggagaac ctcagtctga cgacattgaa gctagccgaa tgaagcgagc      840

agctgcaaag catctaatag aacgctacta ccaccagtta actgagggct gtggaaatga      900

agcctgcacg aatgagtttt gtgcttcctg tccaactttt cttcgtatgg ataataatgc      960

agcagctatt aaagccctcg agctttataa gattaatgca aaactctgtg atcctcatcc     1020

ctccaagaaa ggagcaagct cagcttacct tgagaactcg aaaggtgccc ccaacaactc     1080

ctgctctgag ataaaaatga acaagaaagg cgctagaatt gattttaaag atgtgactta     1140

cttaacagaa gagaaggtat atgaaattct tgaattatgt agagaaagag aggattattc     1200

ccctttaatc cgtgttattg gaagagtttt ttctagtgct gaggcattgg tacagagctt     1260

ccggaaagtt aaacaacaca ccaaggaaga actgaaatct cttcaagcaa aagatgaaga     1320

caaagatgaa gatgaaaagg aaaaagctgc atgttctgct gctgctatgg aagaagactc     1380

agaagcatct tcctcaagga taggtgatag ctcacaggga gacaacaatt tgcaaaaatt     1440

aggccctgat gatgtgtctg tggatattga tgccattaga agggtctaca ccagattgct     1500

ctctaatgaa aaaattgaaa ctgcctttct caatgcactt gtatatttgt cacctaacgt     1560

ggaatgtgac ttgacgtatc acaatgtata ctctcgagat cctaattatc tgaatttgtt     1620

cattatcgta atggagaata gaaatctcca cagtcctgaa tatctggaaa tggctttgcc     1680

attattttgc aaagcgatga gcaagctacc ccttgcagcc caaggaaaac tgatcagact     1740

gtggtctaaa tacaatgcag accagattcg gagaatgatg gagacatttc agcaacttat     1800

tacttataaa gtcataagca atgaatttaa cagtcgaaat ctagtgaatg atgatgatgc     1860

cattgttgct gcttcgaagt gcttgaaaat ggtttactat gcaaatgtag tgggagggga     1920

agtggacaca aatcacaatg aagaagatga tgaagagccc atccctgagt ccagcgagct     1980

gacacttcag gaacttttgg gagaagaaag aagaaacaag aaaggtcctc gagtggaccc     2040

cctggaaact gaacttggtg ttaaaaccct ggattgtcga aaaccactta tcccttttga     2100

agagtttatt aatgaaccac tgaatgaggt tctagaaatg gataaagatt atactttttt     2160

caaagtagaa acagagaaca aattctcttt tatgacatgt ccctttatat tgaatgctgt     2220

cacaaagaat ttgggattat attatgacaa tagaattcgc atgtacagtg aacgaagaat     2280

cactgttctc tacagcttag ttcaaggaca gcagttgaat ccatatttga gactcaaagt     2340

tagacgtgac catatcatag atgatgcact tgtccggcta gagatgatcg ctatggaaaa     2400

tcctgcagac ttgaagaagc agttgtatgt ggaatttgaa ggagaacaag gagttgatga     2460

gggaggtgtt tccaaagaat tttttcagct ggttgtggag gaaatcttca atccagatat     2520

tggtatgttc acatacgatg aatctacaaa attgttttgg tttaatccat cttcttttga     2580

aactgagggt cagtttactc tgattggcat agtactgggt ctggctattt acaataactg     2640

tatactggat gtacattttc ccatggttgt ctacaggaag ctaatgggga aaaaaggaac     2700

ttttcgtgac ttgggagact ctcacccagt tctatatcag agtttaaaag atttattgga     2760

gtatgaaggg aatgtggaag atgacatgat gatcactttc cagatatcac agacagatct     2820

ttttggtaac ccaatgatgt atgatctaaa ggaaaatggt gataaaattc caattacaaa     2880

tgaaaacagg aaggaatttg tcaatcttta ttctgactac attctcaata aatcagtaga     2940

aaaacagttc aaggcttttc ggagaggttt tcatatggtg accaatgaat ctcccttaaa     3000

gtacttattc agaccagaag aaattgaatt gcttatatgt ggaagccgga atctagattt     3060

ccaagcacta gaagaaacta cagaatatga cggtggctat accagggact ctgttctgat     3120

tagggagttc tgggaaatcg ttcattcatt tacagatgaa cagaaaagac tcttcttgca     3180

gtttacaacg ggcacagaca gagcacctgt gggaggacta ggaaaattaa agatgattat     3240

agccaaaaat ggcccagaca cagaaaggtt acctacatct catacttgct ttaatgtgct     3300

tttacttccg gaatactcaa gcaaagaaaa acttaaagag agattgttga aggccatcac     3360

gtatgccaaa ggatttggca tgctgtaaaa caaaacaaaa caaaataaaa caaaaaaaag     3420

gaaggaaaaa aaaagaaaaa atttaaaaaa ttttaaaaat ataacgaggg ataaattttt     3480

ggtggtgata gtgtcccagt acaaaaaggc tgtaagatag tcaaccacag tagtcaccta     3540

tgtctgtgcc tcccttcttt attggggaca tgtgggctgg aacagcagat ttcagctaca     3600

tatatgaaca aatcctttat tattattata attatttttt tgcgtgaaag tgttacatat     3660

tctttcactt gtatgtacag agaggttttt ctgaatattt attttaaggg ttaaatcact     3720

tttgcttgtg tttattactg cttgaggttg agccttttga gtatttaaaa aatatatacc     3780

aacagaacta ctctcccaag gaaaatattg ccaccatttg tagaccacgt aaccttcaag     3840

tatgtgctac ttttttgtcc ctgtatctaa ctcaaatcag gaactgtatt ttttttaatg     3900

atttgctttt gaaacttgaa gtcttgaaaa cagtgtgatg caattactgc tgttctagcc     3960

cccaaagagt tttctgtgca aaatcttgag aatcaatcaa taaagaaaga tggaaggaag     4020

ggagaaattg gaatgtttta actgcagccc tcagaacttt agtaacagca caacaaatta     4080

aaaacaaaaa caactcatgc cacagtatgt cgtcttcatg tgtcttgcaa tgaactgttt     4140

cagtagccaa tcctctttct tagtatatga aaggacaggg atttttgttc ttgttgttct     4200

cgttgttgtt ttaagtttac tggggaaagt gcatttggcc aaatgaaatg gtagtcaagc     4260

ctattgcaac aaagttagga agtttgttgt ttgtttatta taaacaaaaa gcatgtgaaa     4320

gtgcacttaa gatagagttt ttattaatta cttacttatt acctagattt taaatagaca     4380

atccaaagtc tccccttcgt gttgccatca tcttgttgaa tcagccattt tatcgaggca     4440

cgtgatcagt gttgcaacat aatgaaaaag atggctactg tgccttgtgt tacttaatca     4500

tacagtaagc tgacctggaa atgaatgaaa ctattactcc taagaattac attgtatagc     4560

cccacagatt aaatttaatt aattaattca aaacatgtta aacgttactt tcatgtacta     4620

tggaaaagta caagtaggtt tacattactg atttccagaa gtaagtagtt tcccctttcc     4680

tagtcttctg tgtatgtgat gttgttaatt tcttttattg cattataaaa taaaaggatt     4740

atgtattttt aactaaggtg agacattgat atatcctttt gctacaagct atagctaatg     4800

tgctgagctt gtgccttggt gattgattga ttgattgact gattgtttta actgattact     4860

gtagatcaac ctgatgattt gtttgtttga aattggcagg aaaaatgcag ctttcaaatc     4920

attgggggga gaaaaaggat gtctttcagg attattttaa ttaatttttt tcataattga     4980

gacagaactg tttgttatgt accataatgc taaataaaac tgtggcactt ttcaccataa     5040

tttaatttag tggaaaaaga agacaatgct ttccatattg tgataaggta acatggggtt     5100

tttctgggcc agcctttaga acactgttag ggtacatacg ctaccttgat gaaagggacc     5160

ttcgtgcaac tgtagtcatc ttaaaggctt ctcatccact gtgcttctta atgtgtaatt     5220

aaagtgagga gaaattaaat actctgaggg cgttttatat aataaattcg tgaaga         5276


<210>  14
<211>  875
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Glu Lys Leu His Gln Cys Tyr Trp Lys Ser Gly Glu Pro Gln Ser 
1               5                   10                  15      


Asp Asp Ile Glu Ala Ser Arg Met Lys Arg Ala Ala Ala Lys His Leu 
            20                  25                  30          


Ile Glu Arg Tyr Tyr His Gln Leu Thr Glu Gly Cys Gly Asn Glu Ala 
        35                  40                  45              


Cys Thr Asn Glu Phe Cys Ala Ser Cys Pro Thr Phe Leu Arg Met Asp 
    50                  55                  60                  


Asn Asn Ala Ala Ala Ile Lys Ala Leu Glu Leu Tyr Lys Ile Asn Ala 
65                  70                  75                  80  


Lys Leu Cys Asp Pro His Pro Ser Lys Lys Gly Ala Ser Ser Ala Tyr 
                85                  90                  95      


Leu Glu Asn Ser Lys Gly Ala Pro Asn Asn Ser Cys Ser Glu Ile Lys 
            100                 105                 110         


Met Asn Lys Lys Gly Ala Arg Ile Asp Phe Lys Asp Val Thr Tyr Leu 
        115                 120                 125             


Thr Glu Glu Lys Val Tyr Glu Ile Leu Glu Leu Cys Arg Glu Arg Glu 
    130                 135                 140                 


Asp Tyr Ser Pro Leu Ile Arg Val Ile Gly Arg Val Phe Ser Ser Ala 
145                 150                 155                 160 


Glu Ala Leu Val Gln Ser Phe Arg Lys Val Lys Gln His Thr Lys Glu 
                165                 170                 175     


Glu Leu Lys Ser Leu Gln Ala Lys Asp Glu Asp Lys Asp Glu Asp Glu 
            180                 185                 190         


Lys Glu Lys Ala Ala Cys Ser Ala Ala Ala Met Glu Glu Asp Ser Glu 
        195                 200                 205             


Ala Ser Ser Ser Arg Ile Gly Asp Ser Ser Gln Gly Asp Asn Asn Leu 
    210                 215                 220                 


Gln Lys Leu Gly Pro Asp Asp Val Ser Val Asp Ile Asp Ala Ile Arg 
225                 230                 235                 240 


Arg Val Tyr Thr Arg Leu Leu Ser Asn Glu Lys Ile Glu Thr Ala Phe 
                245                 250                 255     


Leu Asn Ala Leu Val Tyr Leu Ser Pro Asn Val Glu Cys Asp Leu Thr 
            260                 265                 270         


Tyr His Asn Val Tyr Ser Arg Asp Pro Asn Tyr Leu Asn Leu Phe Ile 
        275                 280                 285             


Ile Val Met Glu Asn Arg Asn Leu His Ser Pro Glu Tyr Leu Glu Met 
    290                 295                 300                 


Ala Leu Pro Leu Phe Cys Lys Ala Met Ser Lys Leu Pro Leu Ala Ala 
305                 310                 315                 320 


Gln Gly Lys Leu Ile Arg Leu Trp Ser Lys Tyr Asn Ala Asp Gln Ile 
                325                 330                 335     


Arg Arg Met Met Glu Thr Phe Gln Gln Leu Ile Thr Tyr Lys Val Ile 
            340                 345                 350         


Ser Asn Glu Phe Asn Ser Arg Asn Leu Val Asn Asp Asp Asp Ala Ile 
        355                 360                 365             


Val Ala Ala Ser Lys Cys Leu Lys Met Val Tyr Tyr Ala Asn Val Val 
    370                 375                 380                 


Gly Gly Glu Val Asp Thr Asn His Asn Glu Glu Asp Asp Glu Glu Pro 
385                 390                 395                 400 


Ile Pro Glu Ser Ser Glu Leu Thr Leu Gln Glu Leu Leu Gly Glu Glu 
                405                 410                 415     


Arg Arg Asn Lys Lys Gly Pro Arg Val Asp Pro Leu Glu Thr Glu Leu 
            420                 425                 430         


Gly Val Lys Thr Leu Asp Cys Arg Lys Pro Leu Ile Pro Phe Glu Glu 
        435                 440                 445             


Phe Ile Asn Glu Pro Leu Asn Glu Val Leu Glu Met Asp Lys Asp Tyr 
    450                 455                 460                 


Thr Phe Phe Lys Val Glu Thr Glu Asn Lys Phe Ser Phe Met Thr Cys 
465                 470                 475                 480 


Pro Phe Ile Leu Asn Ala Val Thr Lys Asn Leu Gly Leu Tyr Tyr Asp 
                485                 490                 495     


Asn Arg Ile Arg Met Tyr Ser Glu Arg Arg Ile Thr Val Leu Tyr Ser 
            500                 505                 510         


Leu Val Gln Gly Gln Gln Leu Asn Pro Tyr Leu Arg Leu Lys Val Arg 
        515                 520                 525             


Arg Asp His Ile Ile Asp Asp Ala Leu Val Arg Leu Glu Met Ile Ala 
    530                 535                 540                 


Met Glu Asn Pro Ala Asp Leu Lys Lys Gln Leu Tyr Val Glu Phe Glu 
545                 550                 555                 560 


Gly Glu Gln Gly Val Asp Glu Gly Gly Val Ser Lys Glu Phe Phe Gln 
                565                 570                 575     


Leu Val Val Glu Glu Ile Phe Asn Pro Asp Ile Gly Met Phe Thr Tyr 
            580                 585                 590         


Asp Glu Ser Thr Lys Leu Phe Trp Phe Asn Pro Ser Ser Phe Glu Thr 
        595                 600                 605             


Glu Gly Gln Phe Thr Leu Ile Gly Ile Val Leu Gly Leu Ala Ile Tyr 
    610                 615                 620                 


Asn Asn Cys Ile Leu Asp Val His Phe Pro Met Val Val Tyr Arg Lys 
625                 630                 635                 640 


Leu Met Gly Lys Lys Gly Thr Phe Arg Asp Leu Gly Asp Ser His Pro 
                645                 650                 655     


Val Leu Tyr Gln Ser Leu Lys Asp Leu Leu Glu Tyr Glu Gly Asn Val 
            660                 665                 670         


Glu Asp Asp Met Met Ile Thr Phe Gln Ile Ser Gln Thr Asp Leu Phe 
        675                 680                 685             


Gly Asn Pro Met Met Tyr Asp Leu Lys Glu Asn Gly Asp Lys Ile Pro 
    690                 695                 700                 


Ile Thr Asn Glu Asn Arg Lys Glu Phe Val Asn Leu Tyr Ser Asp Tyr 
705                 710                 715                 720 


Ile Leu Asn Lys Ser Val Glu Lys Gln Phe Lys Ala Phe Arg Arg Gly 
                725                 730                 735     


Phe His Met Val Thr Asn Glu Ser Pro Leu Lys Tyr Leu Phe Arg Pro 
            740                 745                 750         


Glu Glu Ile Glu Leu Leu Ile Cys Gly Ser Arg Asn Leu Asp Phe Gln 
        755                 760                 765             


Ala Leu Glu Glu Thr Thr Glu Tyr Asp Gly Gly Tyr Thr Arg Asp Ser 
    770                 775                 780                 


Val Leu Ile Arg Glu Phe Trp Glu Ile Val His Ser Phe Thr Asp Glu 
785                 790                 795                 800 


Gln Lys Arg Leu Phe Leu Gln Phe Thr Thr Gly Thr Asp Arg Ala Pro 
                805                 810                 815     


Val Gly Gly Leu Gly Lys Leu Lys Met Ile Ile Ala Lys Asn Gly Pro 
            820                 825                 830         


Asp Thr Glu Arg Leu Pro Thr Ser His Thr Cys Phe Asn Val Leu Leu 
        835                 840                 845             


Leu Pro Glu Tyr Ser Ser Lys Glu Lys Leu Lys Glu Arg Leu Leu Lys 
    850                 855                 860                 


Ala Ile Thr Tyr Ala Lys Gly Phe Gly Met Leu 
865                 870                 875 


<210>  15
<211>  2970
<212>  DNA
<213>  Homo sapiens

<400>  15
tttttccgga taaggaagcg cgggtcccgc atgagccccg gcggtggcgg cagcgaaaga       60

gaacgaggcg gtggcgggcg gaggcggcgg gcgagggcga ctacgaccag tgaggcggcc      120

gccgcagccc aggcgcgggg gcgacgacag gttaaaaatc tgtaagagcc tgattttaga      180

attcaccagc tcctcagaag tttggcgaaa tatgagttat taagcctacg ctcagatcaa      240

ggtagcagct agactggtgt gacaacctgt ttttaatcag tgactcaaag ctgtgatcac      300

cctgatgtca ccgaatggcc acagcttgta aaagatcagg agaacctcag tctgacgaca      360

ttgaagctag ccgaatgaag cgagcagctg caaagcatct aatagaacgc tactaccacc      420

agttaactga gggctgtgga aatgaagcct gcacgaatga gttttgtgct tcctgtccaa      480

cttttcttcg tatggataat aatgcagcag ctattaaagc cctcgagctt tataagatta      540

atgcaaaact ctgtgatcct catccctcca agaaaggagc aagctcagct taccttgaga      600

actcgaaagg tgcccccaac aactcctgct ctgagataaa aatgaacaag aaaggcgcta      660

gaattgattt taaagatgtg acttacttaa cagaagagaa ggtatatgaa attcttgaat      720

tatgtagaga aagagaggat tattcccctt taatccgtgt tattggaaga gttttttcta      780

gtgctgaggc attggtacag agcttccgga aagttaaaca acacaccaag gaagaactga      840

aatctcttca agcaaaagat gaagacaaag atgaagatga aaaggaaaaa gctgcatgtt      900

ctgctgctgc tatggaagaa gactcagagg catcttcctc aaggataggt gatagctcac      960

agggagacaa caatttgcaa aaattaggcc ctgatgatgt gtctgtggat attgatgcca     1020

ttagaagggt ctacaccaga ttgctctcta atgaaaaaat tgaaactgcc tttctcaatg     1080

cacttgtata tttgtcacct aacgtggaat gtgacttgac gtatcacaat gtatactctc     1140

gagatcctaa ttatctgaat ttgttcatta tcgtaatgga gaatagaaat ctccacagtc     1200

ctgaatatct ggaaatggct ttgccattat tttgcaaagc gatgagcaag ctaccccttg     1260

cagcccaagg aaaactgatc agactgtggt ctaaatacaa tgcagaccag attcggagaa     1320

tgatggagac atttcagcaa cttattactt ataaagtcat aagcaatgaa tttaacagtc     1380

gaaatctagt gaatgatgat gatgccattg ttgctgcttc gaagtgcttg aaaatggttt     1440

actatgcaaa tgtagtggga ggggaagtgg acacaaatca caatgaagaa gatgatgaag     1500

agcccatccc tgagtccagc gagctgacac ttcaggaact tttgggagaa gaaagaagaa     1560

acaagaaagg tcctcgagtg gaccccctgg aaactgaact tggtgttaaa accctggatt     1620

gtcgaaaacc acttatccct tttgaagagt ttattaatga accactgaat gaggttctag     1680

aaatggataa agattatact tttttcaaag tagaaacaga gaacaaattc tcttttatga     1740

catgtccctt tatattgaat gctgtcacaa agaatttggg attatattat gacaatagaa     1800

ttcgcatgta cagtgaacga agaatcactg ttctctacag cttagttcaa ggacagcagt     1860

tgaatccata tttgagactc aaagttagac gtgaccatat catagatgat gcacttgtcc     1920

ggctagagat gatcgctatg gaaaatcctg cagacttgaa gaagcagttg tatgtggaat     1980

ttgaaggaga acaaggagtt gatgagggag gtgtttccaa agaatttttt cagctggttg     2040

tggaggaaat cttcaatcca gatattggta tgttcacata cgatgaatct acaaaattgt     2100

tttggtttaa tccatcttct tttgaaactg agggtcagtt tactctgatt ggcatagtac     2160

tgggtctggc tatttacaat aactgtatac tggatgtaca ttttcccatg gttgtctaca     2220

ggaagctaat ggggaaaaaa ggaacttttc gtgacttggg agactctcac ccagttctat     2280

atcagagttt aaaagattta ttggagtatg aagggaatgt ggaagatgac atgatgatca     2340

ctttccagat atcacagaca gatctttttg gtaacccaat gatgtatgat ctaaaggaaa     2400

atggtgataa aattccaatt acaaatgaaa acaggaagga atttgtcaat ctttattctg     2460

actacattct caataaatca gtagaaaaac agttcaaggc ttttcggaga ggttttcata     2520

tggtgaccaa tgaatctccc ttaaagtact tattcagacc agaagaaatt gaattgctta     2580

tatgtggaag ccggaatcta gatttccaag cactagaaga aactacagaa tatgacggtg     2640

gctataccag ggactctgtt ctgattaggg agttctggga aatcgttcat tcatttacag     2700

atgaacagaa aagactcttc ttgcagttta caacgggcac agacagagca cctgtgggag     2760

gactaggaaa attaaagatg attatagcca aaaatggccc agacacagaa aggttaccta     2820

catctcatac ttgctttaat gtgcttttac ttccggaata ctcaagcaaa gaaaaactta     2880

aagagagatt gttgaaggcc atcacgtatg ccaaaggatt tggcatgctg taaaacaaaa     2940

caaaacaaaa taaaacaaaa aaaaggaagg                                      2970


