                         SEQUENCE LISTING

<110>  Mahdavi, Alborz
 
<120>  GLUCOSE RESPONSIVE INSULINS

<130>  51875-1PCT

<150>  62/157,897
<151>  2015-05-06

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  609
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  1

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
    50                  55                  60                  


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
            100                 105                 110         


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        115                 120                 125             


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
    130                 135                 140                 


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
145                 150                 155                 160 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
                165                 170                 175     


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
            180                 185                 190         


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
        195                 200                 205             


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
    210                 215                 220                 


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
225                 230                 235                 240 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
                245                 250                 255     


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
            260                 265                 270         


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
        275                 280                 285             


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
305                 310                 315                 320 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
                325                 330                 335     


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
            340                 345                 350         


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
        355                 360                 365             


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
    370                 375                 380                 


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
385                 390                 395                 400 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
                405                 410                 415     


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
            420                 425                 430         


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
        435                 440                 445             


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
    450                 455                 460                 


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
465                 470                 475                 480 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
                485                 490                 495     


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
        515                 520                 525             


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
    530                 535                 540                 


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
545                 550                 555                 560 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
                565                 570                 575     


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
        595                 600                 605             


Leu 
    


<210>  2
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  2

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  3
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  3

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30  


<210>  4
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  4

Met Leu Asp Asp Arg Ala Arg Met Glu Ala Ala Lys Lys Glu Lys Val 
1               5                   10                  15      


Glu Gln Ile Leu Ala Glu Phe Gln Leu Gln Glu Glu Asp Leu Lys Lys 
            20                  25                  30          


Val Met Arg Arg Met Gln Lys Glu Met Asp Arg Gly Leu Arg Leu Glu 
        35                  40                  45              


Thr His Glu Glu Ala Ser Val Lys Met Leu Pro Thr Tyr Val Arg Ser 
    50                  55                  60                  


Thr Pro Glu Gly Ser Glu Val Gly Asp Phe Leu Ser Leu Asp Leu Gly 
65                  70                  75                  80  


Gly Thr Asn Phe Arg Val Met Leu Val Lys Val Gly Glu Gly Glu Glu 
                85                  90                  95      


Gly Gln Trp Ser Val Lys Thr Lys His Gln Met Tyr Ser Ile Pro Glu 
            100                 105                 110         


Asp Ala Met Thr Gly Thr Ala Glu Met Leu Phe Asp Tyr Ile Ser Glu 
        115                 120                 125             


Cys Ile Ser Asp Phe Leu Asp Lys His Gln Met Lys His Lys Lys Leu 
    130                 135                 140                 


Pro Leu Gly Phe Thr Phe Ser Phe Pro Val Arg His Glu Asp Ile Asp 
145                 150                 155                 160 


Lys Gly Ile Leu Leu Asn Trp Thr Lys Gly Phe Lys Ala Ser Gly Ala 
                165                 170                 175     


Glu Gly Asn Asn Val Val Gly Leu Leu Arg Asp Ala Ile Lys Arg Arg 
            180                 185                 190         


Gly Asp Phe Glu Met Asp Val Val Ala Met Val Asn Asp Thr Val Ala 
        195                 200                 205             


Thr Met Ile Ser Cys Tyr Tyr Glu Asp His Gln Cys Glu Val Gly Met 
    210                 215                 220                 


Ile Val Gly Thr Gly Cys Asn Ala Cys Tyr Met Glu Glu Met Gln Asn 
225                 230                 235                 240 


Val Glu Leu Val Glu Gly Asp Glu Gly Arg Met Cys Val Asn Thr Glu 
                245                 250                 255     


Trp Gly Ala Phe Gly Asp Ser Gly Glu Leu Asp Glu Phe Leu Leu Glu 
            260                 265                 270         


Tyr Asp Arg Leu Val Asp Glu Ser Ser Ala Asn Pro Gly Gln Gln Leu 
        275                 280                 285             


Tyr Glu Lys Leu Ile Gly Gly Lys Tyr Met Gly Glu Leu Val Arg Leu 
    290                 295                 300                 


Val Leu Leu Arg Leu Val Asp Glu Asn Leu Leu Phe His Gly Glu Ala 
305                 310                 315                 320 


Ser Glu Gln Leu Arg Thr Arg Gly Ala Phe Glu Thr Arg Phe Val Ser 
                325                 330                 335     


Gln Val Glu Ser Asp Thr Gly Asp Arg Lys Gln Ile Tyr Asn Ile Leu 
            340                 345                 350         


Ser Thr Leu Gly Leu Arg Pro Ser Thr Thr Asp Cys Asp Ile Val Arg 
        355                 360                 365             


Arg Ala Cys Glu Ser Val Ser Thr Arg Ala Ala His Met Cys Ser Ala 
    370                 375                 380                 


Gly Leu Ala Gly Val Ile Asn Arg Met Arg Glu Ser Arg Ser Glu Asp 
385                 390                 395                 400 


Val Met Arg Ile Thr Val Gly Val Asp Gly Ser Val Tyr Lys Leu His 
                405                 410                 415     


Pro Ser Phe Lys Glu Arg Phe His Ala Ser Val Arg Arg Leu Thr Pro 
            420                 425                 430         


Ser Cys Glu Ile Thr Phe Ile Glu Ser Glu Glu Gly Ser Gly Arg Gly 
        435                 440                 445             


Ala Ala Leu Val Ser Ala Val Ala Cys Lys Lys Ala Cys Met Leu Gly 
    450                 455                 460                 


Gln 
465 


<210>  5
<211>  917
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  5

Met Ile Ala Ala Gln Leu Leu Ala Tyr Tyr Phe Thr Glu Leu Lys Asp 
1               5                   10                  15      


Asp Gln Val Lys Lys Ile Asp Lys Tyr Leu Tyr Ala Met Arg Leu Ser 
            20                  25                  30          


Asp Glu Thr Leu Ile Asp Ile Met Thr Arg Phe Arg Lys Glu Met Lys 
        35                  40                  45              


Asn Gly Leu Ser Arg Asp Phe Asn Pro Thr Ala Thr Val Lys Met Leu 
    50                  55                  60                  


Pro Thr Phe Val Arg Ser Ile Pro Asp Gly Ser Glu Lys Gly Asp Phe 
65                  70                  75                  80  


Ile Ala Leu Asp Leu Gly Gly Ser Ser Phe Arg Ile Leu Arg Val Gln 
                85                  90                  95      


Val Asn His Glu Lys Asn Gln Asn Val His Met Glu Ser Glu Val Tyr 
            100                 105                 110         


Asp Thr Pro Glu Asn Ile Val His Gly Ser Gly Ser Gln Leu Phe Asp 
        115                 120                 125             


His Val Ala Glu Cys Leu Gly Asp Phe Met Glu Lys Arg Lys Ile Lys 
    130                 135                 140                 


Asp Lys Lys Leu Pro Val Gly Phe Thr Phe Ser Phe Pro Cys Gln Gln 
145                 150                 155                 160 


Ser Lys Ile Asp Glu Ala Ile Leu Ile Thr Trp Thr Lys Arg Phe Lys 
                165                 170                 175     


Ala Ser Gly Val Glu Gly Ala Asp Val Val Lys Leu Leu Asn Lys Ala 
            180                 185                 190         


Ile Lys Lys Arg Gly Asp Tyr Asp Ala Asn Ile Val Ala Val Val Asn 
        195                 200                 205             


Asp Thr Val Gly Thr Met Met Thr Cys Gly Tyr Asp Asp Gln His Cys 
    210                 215                 220                 


Glu Val Gly Leu Ile Ile Gly Thr Gly Thr Asn Ala Cys Tyr Met Glu 
225                 230                 235                 240 


Glu Leu Arg His Ile Asp Leu Val Glu Gly Asp Glu Gly Arg Met Cys 
                245                 250                 255     


Ile Asn Thr Glu Trp Gly Ala Phe Gly Asp Asp Gly Ser Leu Glu Asp 
            260                 265                 270         


Ile Arg Thr Glu Phe Asp Arg Glu Ile Asp Arg Gly Ser Leu Asn Pro 
        275                 280                 285             


Gly Lys Gln Leu Phe Glu Lys Met Val Ser Gly Met Tyr Leu Gly Glu 
    290                 295                 300                 


Leu Val Arg Leu Ile Leu Val Lys Met Ala Lys Glu Gly Leu Leu Phe 
305                 310                 315                 320 


Glu Gly Arg Ile Thr Pro Glu Leu Leu Thr Arg Gly Lys Phe Asn Thr 
                325                 330                 335     


Ser Asp Val Ser Ala Ile Glu Lys Asn Lys Glu Gly Leu His Asn Ala 
            340                 345                 350         


Lys Glu Ile Leu Thr Arg Leu Gly Val Glu Pro Ser Asp Asp Asp Cys 
        355                 360                 365             


Val Ser Val Gln His Val Cys Thr Ile Val Ser Phe Arg Ser Ala Asn 
    370                 375                 380                 


Leu Val Ala Ala Thr Leu Gly Ala Ile Leu Asn Arg Leu Arg Asp Asn 
385                 390                 395                 400 


Lys Gly Thr Pro Arg Leu Arg Thr Thr Val Gly Val Asp Gly Ser Leu 
                405                 410                 415     


Tyr Lys Thr His Pro Gln Tyr Ser Arg Arg Phe His Lys Thr Leu Arg 
            420                 425                 430         


Arg Leu Val Pro Asp Ser Asp Val Arg Phe Leu Leu Ser Glu Ser Gly 
        435                 440                 445             


Ser Gly Lys Gly Ala Ala Met Val Thr Ala Val Ala Tyr Arg Leu Ala 
    450                 455                 460                 


Glu Gln His Arg Gln Ile Glu Glu Thr Leu Ala His Phe His Leu Thr 
465                 470                 475                 480 


Lys Asp Met Leu Leu Glu Val Lys Lys Arg Met Arg Ala Glu Met Glu 
                485                 490                 495     


Leu Gly Leu Arg Lys Gln Thr His Asn Asn Ala Val Val Lys Met Leu 
            500                 505                 510         


Pro Ser Phe Val Arg Arg Thr Pro Asp Gly Thr Glu Asn Gly Asp Phe 
        515                 520                 525             


Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Leu Val Lys 
    530                 535                 540                 


Ile Arg Ser Gly Lys Lys Arg Thr Val Glu Met His Asn Lys Ile Tyr 
545                 550                 555                 560 


Ala Ile Pro Ile Glu Ile Met Gln Gly Thr Gly Glu Glu Leu Phe Asp 
                565                 570                 575     


His Ile Val Ser Cys Ile Ser Asp Phe Leu Asp Tyr Met Gly Ile Lys 
            580                 585                 590         


Gly Pro Arg Met Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys Gln Gln 
        595                 600                 605             


Thr Ser Leu Asp Ala Gly Ile Leu Ile Thr Trp Thr Lys Gly Phe Lys 
    610                 615                 620                 


Ala Thr Asp Cys Val Gly His Asp Val Val Thr Leu Leu Arg Asp Ala 
625                 630                 635                 640 


Ile Lys Arg Arg Glu Glu Phe Asp Leu Asp Val Val Ala Val Val Asn 
                645                 650                 655     


Asp Thr Val Gly Thr Met Met Thr Cys Ala Tyr Glu Glu Pro Thr Cys 
            660                 665                 670         


Glu Val Gly Leu Ile Val Gly Thr Gly Ser Asn Ala Cys Tyr Met Glu 
        675                 680                 685             


Glu Met Lys Asn Val Glu Met Val Glu Gly Asp Gln Gly Gln Met Cys 
    690                 695                 700                 


Ile Asn Met Glu Trp Gly Ala Phe Gly Asp Asn Gly Cys Leu Asp Asp 
705                 710                 715                 720 


Ile Arg Thr His Tyr Asp Arg Leu Val Asp Glu Tyr Ser Leu Asn Ala 
                725                 730                 735     


Gly Lys Gln Arg Tyr Glu Lys Met Ile Ser Gly Met Tyr Leu Gly Glu 
            740                 745                 750         


Ile Val Arg Asn Ile Leu Ile Asp Phe Thr Lys Lys Gly Phe Leu Phe 
        755                 760                 765             


Arg Gly Gln Ile Ser Glu Thr Leu Lys Thr Arg Gly Ile Phe Glu Thr 
    770                 775                 780                 


Lys Phe Leu Ser Gln Ile Glu Ser Asp Arg Leu Ala Leu Leu Gln Val 
785                 790                 795                 800 


Arg Ala Ile Leu Gln Gln Leu Gly Leu Asn Ser Thr Cys Asp Asp Ser 
                805                 810                 815     


Ile Leu Val Lys Thr Val Cys Gly Val Val Ser Arg Arg Ala Ala Gln 
            820                 825                 830         


Leu Cys Gly Ala Gly Met Ala Ala Val Val Asp Lys Ile Arg Glu Asn 
        835                 840                 845             


Arg Gly Leu Asp Arg Leu Asn Val Thr Val Gly Val Asp Gly Thr Leu 
    850                 855                 860                 


Tyr Lys Leu His Pro His Phe Ser Arg Ile Met His Gln Thr Val Lys 
865                 870                 875                 880 


Glu Leu Ser Pro Lys Cys Asn Val Ser Phe Leu Leu Ser Glu Asp Gly 
                885                 890                 895     


Ser Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Gly Val Arg Leu Arg 
            900                 905                 910         


Thr Glu Ala Ser Ser 
        915         


<210>  6
<211>  917
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  6

Met Ile Ala Ser His Leu Leu Ala Tyr Phe Phe Thr Glu Leu Asn His 
1               5                   10                  15      


Asp Gln Val Gln Lys Val Asp Gln Tyr Leu Tyr His Met Arg Leu Ser 
            20                  25                  30          


Asp Glu Thr Leu Leu Glu Ile Ser Lys Arg Phe Arg Lys Glu Met Glu 
        35                  40                  45              


Lys Gly Leu Gly Ala Thr Thr His Pro Thr Ala Ala Val Lys Met Leu 
    50                  55                  60                  


Pro Thr Phe Val Arg Ser Thr Pro Asp Gly Thr Glu His Gly Glu Phe 
65                  70                  75                  80  


Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Trp Val Lys 
                85                  90                  95      


Val Thr Asp Asn Gly Leu Gln Lys Val Glu Met Glu Asn Gln Ile Tyr 
            100                 105                 110         


Ala Ile Pro Glu Asp Ile Met Arg Gly Ser Gly Thr Gln Leu Phe Asp 
        115                 120                 125             


His Ile Ala Glu Cys Leu Ala Asn Phe Met Asp Lys Leu Gln Ile Lys 
    130                 135                 140                 


Asp Lys Lys Leu Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys His Gln 
145                 150                 155                 160 


Thr Lys Leu Asp Glu Ser Phe Leu Val Ser Trp Thr Lys Gly Phe Lys 
                165                 170                 175     


Ser Ser Gly Val Glu Gly Arg Asp Val Val Ala Leu Ile Arg Lys Ala 
            180                 185                 190         


Ile Gln Arg Arg Gly Asp Phe Asp Ile Asp Ile Val Ala Val Val Asn 
        195                 200                 205             


Asp Thr Val Gly Thr Met Met Thr Cys Gly Tyr Asp Asp His Asn Cys 
    210                 215                 220                 


Glu Ile Gly Leu Ile Val Gly Thr Gly Ser Asn Ala Cys Tyr Met Glu 
225                 230                 235                 240 


Glu Met Arg His Ile Asp Met Val Glu Gly Asp Glu Gly Arg Met Cys 
                245                 250                 255     


Ile Asn Met Glu Trp Gly Ala Phe Gly Asp Asp Gly Ser Leu Asn Asp 
            260                 265                 270         


Ile Arg Thr Glu Phe Asp Gln Glu Ile Asp Met Gly Ser Leu Asn Pro 
        275                 280                 285             


Gly Lys Gln Leu Phe Glu Lys Met Ile Ser Gly Met Tyr Met Gly Glu 
    290                 295                 300                 


Leu Val Arg Leu Ile Leu Val Lys Met Ala Lys Glu Glu Leu Leu Phe 
305                 310                 315                 320 


Gly Gly Lys Leu Ser Pro Glu Leu Leu Asn Thr Gly Arg Phe Glu Thr 
                325                 330                 335     


Lys Asp Ile Ser Asp Ile Glu Gly Glu Lys Asp Gly Ile Arg Lys Ala 
            340                 345                 350         


Arg Glu Val Leu Met Arg Leu Gly Leu Asp Pro Thr Gln Glu Asp Cys 
        355                 360                 365             


Val Ala Thr His Arg Ile Cys Gln Ile Val Ser Thr Arg Ser Ala Ser 
    370                 375                 380                 


Leu Cys Ala Ala Thr Leu Ala Ala Val Leu Gln Arg Ile Lys Glu Asn 
385                 390                 395                 400 


Lys Gly Glu Glu Arg Leu Arg Ser Thr Ile Gly Val Asp Gly Ser Val 
                405                 410                 415     


Tyr Lys Lys His Pro His Phe Ala Lys Arg Leu His Lys Thr Val Arg 
            420                 425                 430         


Arg Leu Val Pro Gly Cys Asp Val Arg Phe Leu Arg Ser Glu Asp Gly 
        435                 440                 445             


Ser Gly Lys Gly Ala Ala Met Val Thr Ala Val Ala Tyr Arg Leu Ala 
    450                 455                 460                 


Asp Gln His Arg Ala Arg Gln Lys Thr Leu Glu His Leu Gln Leu Ser 
465                 470                 475                 480 


His Asp Gln Leu Leu Glu Val Lys Arg Arg Met Lys Val Glu Met Glu 
                485                 490                 495     


Arg Gly Leu Ser Lys Glu Thr His Ala Ser Ala Pro Val Lys Met Leu 
            500                 505                 510         


Pro Thr Tyr Val Cys Ala Thr Pro Asp Gly Thr Glu Lys Gly Asp Phe 
        515                 520                 525             


Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Leu Val Arg 
    530                 535                 540                 


Val Arg Asn Gly Lys Trp Gly Gly Val Glu Met His Asn Lys Ile Tyr 
545                 550                 555                 560 


Ala Ile Pro Gln Glu Val Met His Gly Thr Gly Asp Glu Leu Phe Asp 
                565                 570                 575     


His Ile Val Gln Cys Ile Ala Asp Phe Leu Glu Tyr Met Gly Met Lys 
            580                 585                 590         


Gly Val Ser Leu Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys Gln Gln 
        595                 600                 605             


Asn Ser Leu Asp Glu Ser Ile Leu Leu Lys Trp Thr Lys Gly Phe Lys 
    610                 615                 620                 


Ala Ser Gly Cys Glu Gly Glu Asp Val Val Thr Leu Leu Lys Glu Ala 
625                 630                 635                 640 


Ile His Arg Arg Glu Glu Phe Asp Leu Asp Val Val Ala Val Val Asn 
                645                 650                 655     


Asp Thr Val Gly Thr Met Met Thr Cys Gly Phe Glu Asp Pro His Cys 
            660                 665                 670         


Glu Val Gly Leu Ile Val Gly Thr Gly Ser Asn Ala Cys Tyr Met Glu 
        675                 680                 685             


Glu Met Arg Asn Val Glu Leu Val Glu Gly Glu Glu Gly Arg Met Cys 
    690                 695                 700                 


Val Asn Met Glu Trp Gly Ala Phe Gly Asp Asn Gly Cys Leu Asp Asp 
705                 710                 715                 720 


Phe Arg Thr Glu Phe Asp Val Ala Val Asp Glu Leu Ser Leu Asn Pro 
                725                 730                 735     


Gly Lys Gln Arg Phe Glu Lys Met Ile Ser Gly Met Tyr Leu Gly Glu 
            740                 745                 750         


Ile Val Arg Asn Ile Leu Ile Asp Phe Thr Lys Arg Gly Leu Leu Phe 
        755                 760                 765             


Arg Gly Arg Ile Ser Glu Arg Leu Lys Thr Arg Gly Ile Phe Glu Thr 
    770                 775                 780                 


Lys Phe Leu Ser Gln Ile Glu Ser Asp Cys Leu Ala Leu Leu Gln Val 
785                 790                 795                 800 


Arg Ala Ile Leu Gln His Leu Gly Leu Glu Ser Thr Cys Asp Asp Ser 
                805                 810                 815     


Ile Ile Val Lys Glu Val Cys Thr Val Val Ala Arg Arg Ala Ala Gln 
            820                 825                 830         


Leu Cys Gly Ala Gly Met Ala Ala Val Val Asp Arg Ile Arg Glu Asn 
        835                 840                 845             


Arg Gly Leu Asp Ala Leu Lys Val Thr Val Gly Val Asp Gly Thr Leu 
    850                 855                 860                 


Tyr Lys Leu His Pro His Phe Ala Lys Val Met His Glu Thr Val Lys 
865                 870                 875                 880 


Asp Leu Ala Pro Lys Cys Asp Val Ser Phe Leu Gln Ser Glu Asp Gly 
                885                 890                 895     


Ser Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Ala Cys Arg Ile Arg 
            900                 905                 910         


Glu Ala Gly Gln Arg 
        915         


<210>  7
<211>  923
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  7

Met Asp Ser Ile Gly Ser Ser Gly Leu Arg Gln Gly Glu Glu Thr Leu 
1               5                   10                  15      


Ser Cys Ser Glu Glu Gly Leu Pro Gly Pro Ser Asp Ser Ser Glu Leu 
            20                  25                  30          


Val Gln Glu Cys Leu Gln Gln Phe Lys Val Thr Arg Ala Gln Leu Gln 
        35                  40                  45              


Gln Ile Gln Ala Ser Leu Leu Gly Ser Met Glu Gln Ala Leu Arg Gly 
    50                  55                  60                  


Gln Ala Ser Pro Ala Pro Ala Val Arg Met Leu Pro Thr Tyr Val Gly 
65                  70                  75                  80  


Ser Thr Pro His Gly Thr Glu Gln Gly Asp Phe Val Val Leu Glu Leu 
                85                  90                  95      


Gly Ala Thr Gly Ala Ser Leu Arg Val Leu Trp Val Thr Leu Thr Gly 
            100                 105                 110         


Ile Glu Gly His Arg Val Glu Pro Arg Ser Gln Glu Phe Val Ile Pro 
        115                 120                 125             


Gln Glu Val Met Leu Gly Ala Gly Gln Gln Leu Phe Asp Phe Ala Ala 
    130                 135                 140                 


His Cys Leu Ser Glu Phe Leu Asp Ala Gln Pro Val Asn Lys Gln Gly 
145                 150                 155                 160 


Leu Gln Leu Gly Phe Ser Phe Ser Phe Pro Cys His Gln Thr Gly Leu 
                165                 170                 175     


Asp Arg Ser Thr Leu Ile Ser Trp Thr Lys Gly Phe Arg Cys Ser Gly 
            180                 185                 190         


Val Glu Gly Gln Asp Val Val Gln Leu Leu Arg Asp Ala Ile Arg Arg 
        195                 200                 205             


Gln Gly Ala Tyr Asn Ile Asp Val Val Ala Val Val Asn Asp Thr Val 
    210                 215                 220                 


Gly Thr Met Met Gly Cys Glu Pro Gly Val Arg Pro Cys Glu Val Gly 
225                 230                 235                 240 


Leu Val Val Asp Thr Gly Thr Asn Ala Cys Tyr Met Glu Glu Ala Arg 
                245                 250                 255     


His Val Ala Val Leu Asp Glu Asp Arg Gly Arg Val Cys Val Ser Val 
            260                 265                 270         


Glu Trp Gly Ser Phe Ser Asp Asp Gly Ala Leu Gly Pro Val Leu Thr 
        275                 280                 285             


Thr Phe Asp His Thr Leu Asp His Glu Ser Leu Asn Pro Gly Ala Gln 
    290                 295                 300                 


Arg Phe Glu Lys Met Ile Gly Gly Leu Tyr Leu Gly Glu Leu Val Arg 
305                 310                 315                 320 


Leu Val Leu Ala His Leu Ala Arg Cys Gly Val Leu Phe Gly Gly Cys 
                325                 330                 335     


Thr Ser Pro Ala Leu Leu Ser Gln Gly Ser Ile Leu Leu Glu His Val 
            340                 345                 350         


Ala Glu Met Glu Asp Pro Ser Thr Gly Ala Ala Arg Val His Ala Ile 
        355                 360                 365             


Leu Gln Asp Leu Gly Leu Ser Pro Gly Ala Ser Asp Val Glu Leu Val 
    370                 375                 380                 


Gln His Val Cys Ala Ala Val Cys Thr Arg Ala Ala Gln Leu Cys Ala 
385                 390                 395                 400 


Ala Ala Leu Ala Ala Val Leu Ser Cys Leu Gln His Ser Arg Glu Gln 
                405                 410                 415     


Gln Thr Leu Gln Val Ala Val Ala Thr Gly Gly Arg Val Cys Glu Arg 
            420                 425                 430         


His Pro Arg Phe Cys Ser Val Leu Gln Gly Thr Val Met Leu Leu Ala 
        435                 440                 445             


Pro Glu Cys Asp Val Ser Leu Ile Pro Ser Val Asp Gly Gly Gly Arg 
    450                 455                 460                 


Gly Val Ala Met Val Thr Ala Val Ala Ala Arg Leu Ala Ala His Arg 
465                 470                 475                 480 


Arg Leu Leu Glu Glu Thr Leu Ala Pro Phe Arg Leu Asn His Asp Gln 
                485                 490                 495     


Leu Ala Ala Val Gln Ala Gln Met Arg Lys Ala Met Ala Lys Gly Leu 
            500                 505                 510         


Arg Gly Glu Ala Ser Ser Leu Arg Met Leu Pro Thr Phe Val Arg Ala 
        515                 520                 525             


Thr Pro Asp Gly Ser Glu Arg Gly Asp Phe Leu Ala Leu Asp Leu Gly 
    530                 535                 540                 


Gly Thr Asn Phe Arg Val Leu Leu Val Arg Val Thr Thr Gly Val Gln 
545                 550                 555                 560 


Ile Thr Ser Glu Ile Tyr Ser Ile Pro Glu Thr Val Ala Gln Gly Ser 
                565                 570                 575     


Gly Gln Gln Leu Phe Asp His Ile Val Asp Cys Ile Val Asp Phe Gln 
            580                 585                 590         


Gln Lys Gln Gly Leu Ser Gly Gln Ser Leu Pro Leu Gly Phe Thr Phe 
        595                 600                 605             


Ser Phe Pro Cys Arg Gln Leu Gly Leu Asp Gln Gly Ile Leu Leu Asn 
    610                 615                 620                 


Trp Thr Lys Gly Phe Lys Ala Ser Asp Cys Glu Gly Gln Asp Val Val 
625                 630                 635                 640 


Ser Leu Leu Arg Glu Ala Ile Thr Arg Arg Gln Ala Val Glu Leu Asn 
                645                 650                 655     


Val Val Ala Ile Val Asn Asp Thr Val Gly Thr Met Met Ser Cys Gly 
            660                 665                 670         


Tyr Glu Asp Pro Arg Cys Glu Ile Gly Leu Ile Val Gly Thr Gly Thr 
        675                 680                 685             


Asn Ala Cys Tyr Met Glu Glu Leu Arg Asn Val Ala Gly Val Pro Gly 
    690                 695                 700                 


Asp Ser Gly Arg Met Cys Ile Asn Met Glu Trp Gly Ala Phe Gly Asp 
705                 710                 715                 720 


Asp Gly Ser Leu Ala Met Leu Ser Thr Arg Phe Asp Ala Ser Val Asp 
                725                 730                 735     


Gln Ala Ser Ile Asn Pro Gly Lys Gln Arg Phe Glu Lys Met Ile Ser 
            740                 745                 750         


Gly Met Tyr Leu Gly Glu Ile Val Arg His Ile Leu Leu His Leu Thr 
        755                 760                 765             


Ser Leu Gly Val Leu Phe Arg Gly Gln Gln Ile Gln Arg Leu Gln Thr 
    770                 775                 780                 


Arg Asp Ile Phe Lys Thr Lys Phe Leu Ser Glu Ile Glu Ser Asp Ser 
785                 790                 795                 800 


Leu Ala Leu Arg Gln Val Arg Ala Ile Leu Glu Asp Leu Gly Leu Pro 
                805                 810                 815     


Leu Thr Ser Asp Asp Ala Leu Met Val Leu Glu Val Cys Gln Ala Val 
            820                 825                 830         


Ser Gln Arg Ala Ala Gln Leu Cys Gly Ala Gly Val Ala Ala Val Val 
        835                 840                 845             


Glu Lys Ile Arg Glu Asn Arg Gly Leu Glu Glu Leu Ala Val Ser Val 
    850                 855                 860                 


Gly Val Asp Gly Thr Leu Tyr Lys Leu His Pro Arg Phe Ser Ser Leu 
865                 870                 875                 880 


Val Ala Ala Thr Val Arg Glu Leu Ala Pro Arg Cys Val Val Thr Phe 
                885                 890                 895     


Leu Gln Ser Glu Asp Gly Ser Gly Lys Gly Ala Ala Leu Val Thr Ala 
            900                 905                 910         


Val Ala Cys Arg Leu Ala Gln Leu Thr Arg Val 
        915                 920             


<210>  8
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  8

Val Pro Gly Xaa Gly 
1               5   


<210>  9
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  9

Ala Thr Gly Cys Gly Cys Gly Gly Cys Ala Gly Cys Cys Ala Thr Cys 
1               5                   10                  15      


Ala Thr Cys Ala Thr Cys Ala Thr Cys Ala Thr Cys Ala Thr Cys Gly 
            20                  25                  30          


Cys Thr Thr Thr Gly Thr Gly Ala Ala Cys Cys Ala Gly Cys Ala Thr 
        35                  40                  45              


Cys Thr Gly Thr Gly Cys Gly Gly Cys Ala Gly Cys Cys Ala Thr Cys 
    50                  55                  60                  


Thr Gly Gly Thr Gly Gly Ala Ala Gly Cys Gly Cys Thr Gly Thr Ala 
65                  70                  75                  80  


Thr Cys Thr Gly Gly Thr Gly Thr Gly Cys Gly Gly Cys Gly Ala Ala 
                85                  90                  95      


Cys Gly Cys Gly Gly Cys Thr Thr Thr Thr Thr Thr Thr Ala Thr Ala 
            100                 105                 110         


Cys Cys Ala Ala Ala Cys Cys Gly Ala Thr Gly Cys Gly Cys Cys Gly 
        115                 120                 125             


Cys Gly Ala Ala Gly Cys Gly Gly Ala Ala Gly Ala Thr Cys Thr Gly 
    130                 135                 140                 


Cys Ala Gly Gly Thr Gly Gly Gly Cys Cys Ala Gly Gly Thr Gly Gly 
145                 150                 155                 160 


Ala Ala Cys Thr Gly Gly Gly Cys Gly Gly Cys Gly Gly Cys Cys Cys 
                165                 170                 175     


Gly Gly Gly Cys Gly Cys Gly Gly Gly Cys Ala Gly Cys Cys Thr Gly 
            180                 185                 190         


Cys Ala Gly Cys Cys Gly Cys Thr Gly Gly Cys Gly Cys Thr Gly Gly 
        195                 200                 205             


Ala Ala Gly Gly Cys Ala Gly Cys Cys Thr Gly Cys Ala Gly Gly Cys 
    210                 215                 220                 


Gly Cys Gly Cys Gly Gly Cys Ala Thr Thr Gly Thr Gly Gly Ala Ala 
225                 230                 235                 240 


Cys Ala Gly Thr Gly Cys Thr Gly Cys Ala Cys Cys Ala Gly Cys Ala 
                245                 250                 255     


Thr Thr Thr Gly Cys Ala Gly Cys Cys Thr Gly Thr Ala Thr Cys Ala 
            260                 265                 270         


Gly Cys Thr Gly Gly Ala Ala Ala Ala Cys Thr Ala Thr Thr Gly Cys 
        275                 280                 285             


Gly Gly Cys 
    290     


<210>  10
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  10

Met Arg Gly Ser His His His His His His Arg Phe Val Asn Gln His 
1               5                   10                  15      


Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu 
            20                  25                  30          


Arg Gly Phe Phe Tyr Thr Lys Pro Met Arg Arg Glu Ala Glu Asp Leu 
        35                  40                  45              


Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu 
    50                  55                  60                  


Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Ala Arg Gly Ile Val Glu 
65                  70                  75                  80  


Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys 
                85                  90                  95      


Gly 
    


<210>  11
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<400>  11

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Lys Pro Xaa 
            20                  25                  30  


<210>  12
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  First glycine is L-homopropargylglycine (CAS 98891-36-2)

<400>  12

Gly Glu Gly Glu Gly Glu Glu Lys Glu Gly Glu Gly Glu Glu Lys Glu 
1               5                   10                  15      


Gly Glu Gly Glu Glu Lys Glu Gly Glu Gly Glu Glu Lys Gly Glu Gly 
            20                  25                  30          


Glu Glu 
        


<210>  13
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  13

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  14
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  14

Met Lys Ser Ile Tyr Phe Val Ala Gly Leu Phe Val Met Leu Val Gln 
1               5                   10                  15      


Gly Ser Trp Gln Arg Ser Leu Gln Asp Thr Glu Glu Lys Ser Arg Ser 
            20                  25                  30          


Phe Ser Ala Ser Gln Ala Asp Pro Leu Ser Asp Pro Asp Gln Met Asn 
        35                  40                  45              


Glu Asp Lys Arg His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys 
    50                  55                  60                  


Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn 
65                  70                  75                  80  


Thr Lys Arg Asn Arg Asn Asn Ile Ala Lys Arg His Asp Glu Phe Glu 
                85                  90                  95      


Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu 
            100                 105                 110         


Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
        115                 120                 125             


Arg Arg Asp Phe Pro Glu Glu Val Ala Ile Val Glu Glu Leu Gly Arg 
    130                 135                 140                 


Arg His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp 
145                 150                 155                 160 


Asn Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile 
                165                 170                 175     


Thr Asp Arg Lys 
            180 


<210>  15
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  15

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  16
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  16

His Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val 
1               5                   10                  15      


Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu 
            20                  25                  30          


Val Lys Gly Arg Asn His 
        35              


<210>  17
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  17

His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  18
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  18

Thr Val Glu Gly Val Glu Ala Leu Lys Leu His Ile Leu Ala Ala Leu 
1               5                   10                  15      


Pro 
    


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  19

Asp Ile Cys Leu Pro Arg Trp Gly Cys 
1               5                   


<210>  20
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  20

Cys Val Glu Glu Ala Ser 
1               5       


