                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
 
<120>  METHODS OF ISOLATING T CELLS AND T CELL RECEPTORS HAVING 
       ANTIGENIC SPECIFICITY FOR A CANCER-SPECIFIC MUTATION FROM 
       PERIPHERAL BLOOD

<130>  723574

<150>  US 62/155,830
<151>  2015-05-01

<160>  82    

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1

Cys Ala Val Arg Asp Arg Gly Thr Gly Gly Phe Lys Thr Ile Phe 
1               5                   10                  15  


<210>  2
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  2

Cys Ala Ser Ile Thr Lys Asp Arg Ala Tyr Glu Gln Tyr Phe 
1               5                   10                  


<210>  3
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  3

Cys Ala Tyr Arg Ser Ala Ser Asp Met Arg Phe 
1               5                   10      


<210>  4
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  4

Cys Ala Ser Ser Pro Glu Thr Gly Gly Ile Ser Glu Gln Tyr Phe 
1               5                   10                  15  


<210>  5
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp Ser Ala Ile Tyr Asn 
1               5       


<210>  6
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  6

Ile Gln Ser Ser Gln Arg Glu 
1               5           


<210>  7
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  7

Ala Val Asp Asn Phe Asn Lys Phe Tyr 
1               5                   


<210>  8
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  8

Ser Gly His Thr Ala 
1               5   


<210>  9
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  9

Phe Gln Gly Thr Gly Ala 
1               5       


<210>  10
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  10

Ala Ser Ser Ser Gln Gly Gly Tyr Gly Tyr Thr 
1               5                   10      


<210>  11
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Glu Thr Leu Leu Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln Trp 
1               5                   10                  15      


Val Ser Ser Lys Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val 
            20                  25                  30          


Pro Glu Gly Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala 
        35                  40                  45              


Ile Tyr Asn Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr 
    50                  55                  60                  


Ser Leu Leu Leu Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly Arg 
65                  70                  75                  80  


Leu Asn Ala Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile 
                85                  90                  95      


Ala Ala Ser Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Asp 
            100                 105                 110         


Asn Phe Asn Lys Phe Tyr Phe Gly Ser Gly Thr Lys Leu Asn Val Lys 
        115                 120                 125             


Pro 
    


<210>  12
<211>  132
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is Gly or Ala

<400>  12

Met Xaa Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Thr Pro Ser Asn Lys Val Thr 
            20                  25                  30          


Glu Lys Gly Lys Tyr Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Thr Ala Leu Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Ile Tyr Phe Gln Gly Thr Gly Ala Ala Asp Asp Ser Gly Leu Pro 
65                  70                  75                  80  


Asn Asp Arg Phe Phe Ala Val Arg Pro Glu Gly Ser Val Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Arg Thr Glu Arg Gly Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Ser Gln Gly Gly Tyr Gly Tyr Thr Phe Gly Ser Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Val 
    130         


<210>  13
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  13

Thr Thr Ser Asp Arg 
1               5   


<210>  14
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  14

Leu Leu Ser Asn Gly Ala Val 
1               5           


<210>  15
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  15

Ala Gly Ser Gly Ser Arg Leu Thr 
1               5               


<210>  16
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  16

Ser Gly His Val Ser 
1               5   


<210>  17
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  17

Phe Asn Tyr Glu Ala Gln 
1               5       


<210>  18
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  18

Ala Ser Ser Phe Asp Arg Gly Tyr Gly Tyr Thr 
1               5                   10      


<210>  19
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Lys Lys Leu Leu Ala Met Ile Leu Trp Leu Gln Leu Asp Arg Leu 
1               5                   10                  15      


Ser Gly Glu Leu Lys Val Glu Gln Asn Pro Leu Phe Leu Ser Met Gln 
            20                  25                  30          


Glu Gly Lys Asn Tyr Thr Ile Tyr Cys Asn Tyr Ser Thr Thr Ser Asp 
        35                  40                  45              


Arg Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Lys Ser Leu Glu Ser Leu 
    50                  55                  60                  


Phe Val Leu Leu Ser Asn Gly Ala Val Lys Gln Glu Gly Arg Leu Met 
65                  70                  75                  80  


Ala Ser Leu Asp Thr Lys Ala Arg Leu Ser Thr Leu His Ile Thr Ala 
                85                  90                  95      


Ala Val His Asp Leu Ser Ala Thr Tyr Phe Cys Ala Gly Ser Gly Ser 
            100                 105                 110         


Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu Thr Val Asn Pro 
        115                 120                 125     


<210>  20
<211>  132
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is Gly or Ala

<400>  20

Met Xaa Thr Ser Leu Leu Cys Trp Val Val Leu Gly Phe Leu Gly Thr 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Ser Pro Arg Tyr Lys Val Thr 
            20                  25                  30          


Lys Arg Gly Gln Asp Val Ala Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Val Ser Leu Tyr Trp Tyr Arg Gln Ala Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Asn Tyr Glu Ala Gln Gln Asp Lys Ser Gly Leu Pro 
65                  70                  75                  80  


Asn Asp Arg Phe Ser Ala Glu Arg Pro Glu Gly Ser Ile Ser Thr Leu 
                85                  90                  95      


Thr Ile Gln Arg Thr Glu Gln Arg Asp Ser Ala Met Tyr Arg Cys Ala 
            100                 105                 110         


Ser Ser Phe Asp Arg Gly Tyr Gly Tyr Thr Phe Gly Ser Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Val 
    130         


<210>  21
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  21

Thr Ser Glu Asn Asn Tyr 
1               5       


<210>  22
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  22

Gln Glu Ala Tyr Lys Gln Gln Asn 
1               5               


<210>  23
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  23

Ala Phe Thr Glu Leu Asn Ser Gly Gly Ser Asn Tyr Lys Leu Thr 
1               5                   10                  15  


<210>  24
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Asn His Glu Tyr 
1               5   


<210>  25
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  25

Ser Met Asn Val Glu Val 
1               5       


<210>  26
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  26

Ala Ser Ser Leu Ser Gly Gly Leu Leu Arg Thr Gly Glu Leu Phe 
1               5                   10                  15  


<210>  27
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Thr Arg Val Ser Leu Leu Trp Ala Val Val Val Ser Thr Cys Leu 
1               5                   10                  15      


Glu Ser Gly Met Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser 
            20                  25                  30          


Val Gln Glu Ala Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Glu Asn Asn Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln 
    50                  55                  60                  


Met Ile Leu Val Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Asn Arg Phe Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser 
                85                  90                  95      


Leu Lys Ile Ser Asp Ser Gln Leu Gly Asp Thr Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Phe Thr Glu Leu Asn Ser Gly Gly Ser Asn Tyr Lys Leu Thr Phe 
        115                 120                 125             


Gly Lys Gly Thr Leu Leu Thr Val Asn Pro 
    130                 135             


<210>  28
<211>  135
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is Gly or Ala

<400>  28

Met Xaa Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Leu Ser Gly Gly Leu Leu Arg Thr Gly Glu Leu Phe Phe Gly Glu 
        115                 120                 125             


Gly Ser Arg Leu Thr Val Leu 
    130                 135 


<210>  29
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  29

Asn Ser Ala Ser Gln Ser 
1               5       


<210>  30
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  30

Val Tyr Ser Ser Gly Asn 
1               5       


<210>  31
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  31

Val Val Asn Thr Asn Ala Gly Lys Ser Thr 
1               5                   10  


<210>  32
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  32

Ser Gly Asp Leu Ser 
1               5   


<210>  33
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  33

Tyr Tyr Asn Gly Glu Glu 
1               5       


<210>  34
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  34

Ala Ser Ser Gly Arg Val Thr Gly Gly Phe Tyr Asn Glu Gln Phe 
1               5                   10                  15  


<210>  35
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Ile Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Arg Lys Glu Val Glu Gln Asp Pro Gly Pro Phe 
            20                  25                  30          


Asn Val Pro Glu Gly Ala Thr Val Ala Phe Asn Cys Thr Tyr Ser Asn 
        35                  40                  45              


Ser Ala Ser Gln Ser Phe Phe Trp Tyr Arg Gln Asp Cys Arg Lys Glu 
    50                  55                  60                  


Pro Lys Leu Leu Met Ser Val Tyr Ser Ser Gly Asn Glu Asp Gly Arg 
65                  70                  75                  80  


Phe Thr Ala Gln Leu Asn Arg Ala Ser Gln Tyr Ile Ser Leu Leu Ile 
                85                  90                  95      


Arg Asp Ser Lys Leu Ser Asp Ser Ala Thr Tyr Leu Cys Val Val Asn 
            100                 105                 110         


Thr Asn Ala Gly Lys Ser Thr Phe Gly Asp Gly Thr Thr Leu Thr Val 
        115                 120                 125             


Lys Pro 
    130 


<210>  36
<211>  135
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is Gly or Ala

<400>  36

Met Xaa Phe Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr 
            20                  25                  30          


Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp 
        35                  40                  45              


Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Ile Gln Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu 
65                  70                  75                  80  


Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn 
                85                  90                  95      


Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Gly Arg Val Thr Gly Gly Phe Tyr Asn Glu Gln Phe Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Leu 
    130                 135 


<210>  37
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  37

Asp Arg Gly Ser Gln Ser 
1               5       


<210>  38
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  38

Ile Tyr Ser Asn Gly Asp 
1               5       


<210>  39
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  39

Ala Ser Ser Gly Gly Asn Thr Pro Leu Val 
1               5                   10  


<210>  40
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Asn His Glu Tyr 
1               5   


<210>  41
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  41

Ser Met Asn Val Glu Val 
1               5       


<210>  42
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  42

Ala Ser Ser Phe Gly Gly Ala Tyr Glu Gln Tyr 
1               5                   10      


<210>  43
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Gly Gly Asn Thr Pro Leu Val Phe Gly Lys Gly Thr Arg Leu Ser 
        115                 120                 125             


Val Ile Ala 
    130     


<210>  44
<211>  131
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is Gly or Ala

<400>  44

Met Xaa Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Phe Gly Gly Ala Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Thr 
    130     


<210>  45
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  X is Thr or Cys

<220>
<221>  MISC_FEATURE
<222>  (112)..(112)
<223>  X is Ser, Gly, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<220>
<221>  MISC_FEATURE
<222>  (114)..(114)
<223>  X is Met, Gly, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<220>
<221>  MISC_FEATURE
<222>  (115)..(115)
<223>  X is Gly, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<400>  45

Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Xaa 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Xaa 
            100                 105                 110         


Val Xaa Xaa Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  46
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  X is Ser or Cys

<400>  46

Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
1               5                   10                  15      


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Xaa Thr Asp Pro Gln Ala Tyr Lys 
    50                  55                  60                  


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
65                  70                  75                  80  


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
                85                  90                  95      


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
            100                 105                 110         


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
        115                 120                 125             


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
    130                 135                 140                 


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
145                 150                 155                 160 


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
                165                 170             


<210>  47
<211>  137
<212>  PRT
<213>  Mus musculus

<400>  47

Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Thr 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Ser 
            100                 105                 110         


Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  48
<211>  173
<212>  PRT
<213>  Mus musculus

<400>  48

Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
1               5                   10                  15      


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys 
    50                  55                  60                  


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
65                  70                  75                  80  


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
                85                  90                  95      


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
            100                 105                 110         


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
        115                 120                 125             


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
    130                 135                 140                 


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
145                 150                 155                 160 


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
                165                 170             


<210>  49
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49

Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
            100                 105                 110         


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  50
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50

Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
1               5                   10                  15      


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys 
    50                  55                  60                  


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
65                  70                  75                  80  


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
                85                  90                  95      


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
            100                 105                 110         


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
        115                 120                 125             


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
    130                 135                 140                 


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
145                 150                 155                 160 


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
                165                 170             


<210>  51
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51

Met Glu Thr Leu Leu Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln Trp 
1               5                   10                  15      


Val Ser Ser Lys Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val 
            20                  25                  30          


Pro Glu Gly Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala 
        35                  40                  45              


Ile Tyr Asn Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr 
    50                  55                  60                  


Ser Leu Leu Leu Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly Arg 
65                  70                  75                  80  


Leu Asn Ala Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile 
                85                  90                  95      


Ala Ala Ser Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Asp 
            100                 105                 110         


Asn Phe Asn Lys Phe Tyr Phe Gly Ser Gly Thr Lys Leu Asn Val Lys 
        115                 120                 125             


Pro Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro 
    130                 135                 140                 


Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln 
145                 150                 155                 160 


Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys 
                165                 170                 175     


Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile 
            180                 185                 190         


Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu 
        195                 200                 205             


Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu 
    210                 215                 220                 


Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu 
225                 230                 235                 240 


Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn 
                245                 250                 255     


Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265     


<210>  52
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52

Met Ala Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Thr Pro Ser Asn Lys Val Thr 
            20                  25                  30          


Glu Lys Gly Lys Tyr Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Thr Ala Leu Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Ile Tyr Phe Gln Gly Thr Gly Ala Ala Asp Asp Ser Gly Leu Pro 
65                  70                  75                  80  


Asn Asp Arg Phe Phe Ala Val Arg Pro Glu Gly Ser Val Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Arg Thr Glu Arg Gly Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Ser Gln Gly Gly Tyr Gly Tyr Thr Phe Gly Ser Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Val Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
    290                 295                 300                 


Ser 
305 


<210>  53
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53

Met Lys Lys Leu Leu Ala Met Ile Leu Trp Leu Gln Leu Asp Arg Leu 
1               5                   10                  15      


Ser Gly Glu Leu Lys Val Glu Gln Asn Pro Leu Phe Leu Ser Met Gln 
            20                  25                  30          


Glu Gly Lys Asn Tyr Thr Ile Tyr Cys Asn Tyr Ser Thr Thr Ser Asp 
        35                  40                  45              


Arg Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Lys Ser Leu Glu Ser Leu 
    50                  55                  60                  


Phe Val Leu Leu Ser Asn Gly Ala Val Lys Gln Glu Gly Arg Leu Met 
65                  70                  75                  80  


Ala Ser Leu Asp Thr Lys Ala Arg Leu Ser Thr Leu His Ile Thr Ala 
                85                  90                  95      


Ala Val His Asp Leu Ser Ala Thr Tyr Phe Cys Ala Gly Ser Gly Ser 
            100                 105                 110         


Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu Thr Val Asn Pro Asp Ile 
        115                 120                 125             


Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln 
    130                 135                 140                 


Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val 
145                 150                 155                 160 


Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu 
                165                 170                 175     


Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser 
            180                 185                 190         


Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala 
        195                 200                 205             


Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys 
    210                 215                 220                 


Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile 
225                 230                 235                 240 


Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met 
                245                 250                 255     


Thr Leu Arg Leu Trp Ser Ser 
            260             


<210>  54
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54

Met Ala Thr Ser Leu Leu Cys Trp Val Val Leu Gly Phe Leu Gly Thr 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Ser Pro Arg Tyr Lys Val Thr 
            20                  25                  30          


Lys Arg Gly Gln Asp Val Ala Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Val Ser Leu Tyr Trp Tyr Arg Gln Ala Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Asn Tyr Glu Ala Gln Gln Asp Lys Ser Gly Leu Pro 
65                  70                  75                  80  


Asn Asp Arg Phe Ser Ala Glu Arg Pro Glu Gly Ser Ile Ser Thr Leu 
                85                  90                  95      


Thr Ile Gln Arg Thr Glu Gln Arg Asp Ser Ala Met Tyr Arg Cys Ala 
            100                 105                 110         


Ser Ser Phe Asp Arg Gly Tyr Gly Tyr Thr Phe Gly Ser Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Val Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
    290                 295                 300                 


Ser 
305 


<210>  55
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55

Met Thr Arg Val Ser Leu Leu Trp Ala Val Val Val Ser Thr Cys Leu 
1               5                   10                  15      


Glu Ser Gly Met Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser 
            20                  25                  30          


Val Gln Glu Ala Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Glu Asn Asn Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln 
    50                  55                  60                  


Met Ile Leu Val Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Asn Arg Phe Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser 
                85                  90                  95      


Leu Lys Ile Ser Asp Ser Gln Leu Gly Asp Thr Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Phe Thr Glu Leu Asn Ser Gly Gly Ser Asn Tyr Lys Leu Thr Phe 
        115                 120                 125             


Gly Lys Gly Thr Leu Leu Thr Val Asn Pro Asp Ile Gln Asn Pro Glu 
    130                 135                 140                 


Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu 
145                 150                 155                 160 


Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met 
                165                 170                 175     


Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala 
            180                 185                 190         


Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser 
        195                 200                 205             


Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser 
    210                 215                 220                 


Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr 
225                 230                 235                 240 


Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile 
                245                 250                 255     


Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu 
            260                 265                 270         


Trp Ser Ser 
        275 


<210>  56
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56

Met Ala Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Leu Ser Gly Gly Leu Leu Arg Thr Gly Glu Leu Phe Phe Gly Glu 
        115                 120                 125             


Gly Ser Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro 
    130                 135                 140                 


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys 
            180                 185                 190         


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
225                 230                 235                 240 


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asn Ser 
305             


<210>  57
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57

Met Ile Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Arg Lys Glu Val Glu Gln Asp Pro Gly Pro Phe 
            20                  25                  30          


Asn Val Pro Glu Gly Ala Thr Val Ala Phe Asn Cys Thr Tyr Ser Asn 
        35                  40                  45              


Ser Ala Ser Gln Ser Phe Phe Trp Tyr Arg Gln Asp Cys Arg Lys Glu 
    50                  55                  60                  


Pro Lys Leu Leu Met Ser Val Tyr Ser Ser Gly Asn Glu Asp Gly Arg 
65                  70                  75                  80  


Phe Thr Ala Gln Leu Asn Arg Ala Ser Gln Tyr Ile Ser Leu Leu Ile 
                85                  90                  95      


Arg Asp Ser Lys Leu Ser Asp Ser Ala Thr Tyr Leu Cys Val Val Asn 
            100                 105                 110         


Thr Asn Ala Gly Lys Ser Thr Phe Gly Asp Gly Thr Thr Leu Thr Val 
        115                 120                 125             


Lys Pro Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp 
    130                 135                 140                 


Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser 
145                 150                 155                 160 


Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp 
                165                 170                 175     


Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala 
            180                 185                 190         


Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys 
        195                 200                 205             


Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr 
    210                 215                 220                 


Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn 
225                 230                 235                 240 


Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
                245                 250                 255     


Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265         


<210>  58
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58

Met Ala Phe Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr 
            20                  25                  30          


Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp 
        35                  40                  45              


Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Ile Gln Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu 
65                  70                  75                  80  


Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn 
                85                  90                  95      


Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Gly Arg Val Thr Gly Gly Phe Tyr Asn Glu Gln Phe Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro 
    130                 135                 140                 


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys 
            180                 185                 190         


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
225                 230                 235                 240 


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asn Ser 
305             


<210>  59
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Gly Gly Asn Thr Pro Leu Val Phe Gly Lys Gly Thr Arg Leu Ser 
        115                 120                 125             


Val Ile Ala Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             


<210>  60
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60

Met Ala Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Phe Gly Gly Ala Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Thr Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
    130                 135                 140                 


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
            180                 185                 190         


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
        195                 200                 205             


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
    210                 215                 220                 


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
225                 230                 235                 240 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
                245                 250                 255     


Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala 
            260                 265                 270         


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
        275                 280                 285             


Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300                 


<210>  61
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  61

Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
1               5                   10                  15      


Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln 
            20                  25                  30          


Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys 
        35                  40                  45              


Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val 
    50                  55                  60                  


Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn 
65                  70                  75                  80  


Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys 
                85                  90                  95      


Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn 
            100                 105                 110         


Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val 
        115                 120                 125             


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135                 140         


<210>  62
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  62

Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
1               5                   10                  15      


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
    50                  55                  60                  


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
65                  70                  75                  80  


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
                85                  90                  95      


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
            100                 105                 110         


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
        115                 120                 125             


Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser 
    130                 135                 140                 


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
145                 150                 155                 160 


Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp 
                165                 170                 175     


Phe 
    


<210>  63
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  63

Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser 
1               5                   10                  15      


Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala 
            20                  25                  30          


Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
        35                  40                  45              


Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu 
    50                  55                  60                  


Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg 
65                  70                  75                  80  


Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln 
                85                  90                  95      


Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg 
            100                 105                 110         


Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala 
        115                 120                 125             


Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala 
    130                 135                 140                 


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
145                 150                 155                 160 


Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Ser 
                165                 170                 175     


Arg Gly 
        


<210>  64
<211>  388
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  64
atggagaccc tcttgggcct gcttatcctt tggctgcagc tgcaatgggt gagcagcaaa       60

caggaggtga cgcagattcc tgcagctctg agtgtcccag aaggagaaaa cttggttctc      120

aactgcagtt tcactgatag cgctatttac aacctccagt ggtttaggca ggaccctggg      180

aaaggtctca catctctgtt gcttattcag tcaagtcaga gagagcaaac aagtggaaga      240

cttaatgcct cgctggataa atcatcagga cgtagtactt tatacattgc agcttctcag      300

cctggtgact cagccaccta cctctgtgct gtagacaact tcaacaaatt ttactttgga      360

tctgggacca aactcaatgt aaaaccaa                                         388


<210>  65
<211>  397
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  65
atgggcacca ggctcctctg ctgggcagcc ctgtgcctcc tgggggcaga tcacacaggt       60

gctggagtct cccagacccc cagtaacaag gtcacagaga agggaaaata tgtagagctc      120

aggtgtgatc caatttcagg tcatactgcc ctttactggt accgacaaag cctggggcag      180

ggcccagagt ttctaattta cttccaaggc acgggtgcgg cagatgactc agggctgccc      240

aacgatcggt tctttgcagt caggcctgag ggatccgtct ctactctgaa gatccagcgc      300

acagagcggg gggactcagc cgtgtatctc tgtgccagca gctcacaggg gggctatggc      360

tacaccttcg gttcggggac caggttaacc gttgtag                               397


<210>  66
<211>  379
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  66
atgaagaagc tactagcaat gattctgtgg cttcaactag accggttaag tggagagctg       60

aaagtggaac aaaaccctct gttcctgagc atgcaggagg gaaaaaacta taccatctac      120

tgcaattatt caaccacttc agacagactg tattggtaca ggcaggatcc tgggaaaagt      180

ctggaatctc tgtttgtgtt gctatcaaat ggagcagtga agcaggaggg acgattaatg      240

gcctcacttg ataccaaagc ccgtctcagc accctccaca tcacagctgc cgtgcatgac      300

ctctctgcca cctacttctg tgccggaagt ggctctaggt tgacctttgg ggaaggaaca      360

cagctcacag tgaatcctg                                                   379


<210>  67
<211>  397
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  67
atgggcacca gtctcctatg ctgggtggtc ctgggtttcc tagggacaga tcacacaggt       60

gctggagtct cccagtctcc caggtacaaa gtcacaaaga ggggacagga tgtagctctc      120

aggtgtgatc caatttcggg tcatgtatcc ctttattggt accgacaggc cctggggcag      180

ggcccagagt ttctgactta cttcaattat gaagcccaac aagacaaatc agggctgccc      240

aatgatcggt tctctgcaga gaggcctgag ggatccatct ccactctgac gatccagcgc      300

acagagcagc gggactcggc catgtatcgc tgtgccagca gctttgacag gggctatggc      360

tacaccttcg gttcggggac caggttaacc gttgtag                               397


<210>  68
<211>  415
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  68
atgacacgag ttagcttgct gtgggcagtc gtggtctcca cctgtcttga atccggcatg       60

gcccagacag tcactcagtc tcaaccagag atgtctgtgc aggaggcaga gactgtgacc      120

ctgagttgca catatgacac cagtgagaat aattattatt tgttctggta caagcagcct      180

cccagcaggc agatgattct cgttattcgc caagaagctt ataagcaaca gaatgcaacg      240

gagaatcgtt tctctgtgaa cttccagaaa gcagccaaat ccttcagtct caagatctca      300

gactcacagc tgggggacac tgcgatgtat ttctgtgctt tcacggaact aaatagtgga      360

ggtagcaact ataaactgac atttggaaaa ggaactctct taaccgtgaa tccaa           415


<210>  69
<211>  406
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  69
atgggccccc agctccttgg ctatgtggtc ctttgccttc taggagcagg ccccctggaa       60

gcccaagtga cccagaaccc aagatacctc atcacagtga ctggaaagaa gttaacagtg      120

acttgttctc agaatatgaa ccatgagtat atgtcctggt atcgacaaga cccagggctg      180

ggcttaaggc agatctacta ttcaatgaat gttgaggtga ctgataaggg agatgttcct      240

gaagggtaca aagtctctcg aaaagagaag aggaatttcc ccctgatcct ggagtcgccc      300

agccccaacc agacctctct gtacttctgt gccagcagtc tatccggggg actactcagg      360

accggggagc tgttttttgg agaaggctct aggctgaccg tactgg                     406


<210>  70
<211>  391
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  70
atgatatcct tgagagtttt actggtgatc ctgtggcttc agttaagctg ggtttggagc       60

caacggaagg aggtggagca ggatcctgga cccttcaatg ttccagaggg agccactgtc      120

gctttcaact gtacttacag caacagtgct tctcagtctt tcttctggta cagacaggat      180

tgcaggaaag aacctaagtt gctgatgtcc gtatactcca gtggtaatga agatggaagg      240

tttacagcac agctcaatag agccagccag tatatttccc tgctcatcag agactccaag      300

ctcagtgatt cagccaccta cctctgtgtg gtgaacacca atgcaggcaa atcaaccttt      360

ggggatggga ctacgctcac tgtgaagcca a                                     391


<210>  71
<211>  406
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  71
atgggcttca ggctcctctg ctgtgtggcc ttttgtctcc tgggagcagg cccagtggat       60

tctggagtca cacaaacccc aaagcacctg atcacagcaa ctggacagcg agtgacgctg      120

agatgctccc ctaggtctgg agacctctct gtgtactggt accaacagag cctggaccag      180

ggcctccagt tcctcattca gtattataat ggagaagaga gagcaaaagg aaacattctt      240

gaacgattct ccgcacaaca gttccctgac ttgcactctg aactaaacct gagctctctg      300

gagctggggg actcagcttt gtatttctgt gccagcagcg gcagggtgac agggggcttc      360

tacaatgagc agttcttcgg gccagggaca cggctcaccg tgctag                     406


<210>  72
<211>  394
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  72
atgaaatcct tgagagtttt actagtgatc ctgtggcttc agttgagctg ggtttggagc       60

caacagaagg aggtggagca gaattctgga cccctcagtg ttccagaggg agccattgcc      120

tctctcaact gcacttacag tgaccgaggt tcccagtcct tcttctggta cagacaatat      180

tctgggaaaa gccctgagtt gataatgttc atatactcca atggtgacaa agaagatgga      240

aggtttacag cacagctcaa taaagccagc cagtatgttt ctctgctcat cagagactcc      300

cagcccagtg attcagccac ctacctctgt gcctcgtcgg gaggaaacac acctcttgtc      360

tttggaaagg gcacaagact ttctgtgatt gcaa                                  394


<210>  73
<211>  394
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  73
atgggccccc agctccttgg ctatgtggtc ctttgccttc taggagcagg ccccctggaa       60

gcccaagtga cccagaaccc aagatacctc atcacagtga ctggaaagaa gttaacagtg      120

acttgttctc agaatatgaa ccatgagtat atgtcctggt atcgacaaga cccagggctg      180

ggcttaaggc agatctacta ttcaatgaat gttgaggtga ctgataaggg agatgttcct      240

gaagggtaca aagtctctcg aaaagagaag aggaatttcc ccctgatcct ggagtcgccc      300

agccccaacc agacctctct gtacttctgt gccagcagtt ttggtggggc ctacgagcag      360

tacttcgggc cgggcaccag gctcacggtc acag                                  394


<210>  74
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu 
1               5                   10                  15      


Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala 
            20                  25                  30          


Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val 
        35                  40                  45              


Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser 
    50                  55                  60                  


Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp 
65                  70                  75                  80  


Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser 
                85                  90                  95      


Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys 
            100                 105                 110         


Val Ala Lys Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu 
        115                 120                 125             


Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln 
    130                 135                 140                 


Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Asp Ser Leu Gln Leu 
145                 150                 155                 160 


Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Val Tyr 
                165                 170                 175     


Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp 
            180                 185                 190         


Asn Gln Ile Met Pro Lys Thr Gly Phe Leu Ile Ile Ile Leu Ala Ile 
        195                 200                 205             


Ile Ala Lys Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu 
    210                 215                 220                 


Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Phe Gly 
225                 230                 235                 240 


Asp Pro Lys Lys Leu Leu Thr Gln Tyr Phe Val Gln Glu Asn Tyr Leu 
                245                 250                 255     


Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu 
            260                 265                 270         


Trp Gly Pro Arg Ala Leu Ile Glu Thr Ser Tyr Val Lys Val Leu His 
        275                 280                 285             


His Met Val Lys Ile Ser Gly Gly Pro Arg Ile Ser Tyr Pro Leu Leu 
    290                 295                 300                 


His Glu Trp Ala Leu Arg Glu Gly Glu Glu 
305                 310                 


<210>  75
<211>  1337
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Asp Phe Thr Ala Gln Pro Lys Pro Ala Thr Ala Leu Cys Gly Val 
1               5                   10                  15      


Val Ser Ala Asp Gly Lys Ile Ala Tyr Pro Pro Gly Val Lys Glu Ile 
            20                  25                  30          


Thr Asp Lys Ile Thr Thr Asp Glu Met Ile Lys Arg Leu Lys Met Val 
        35                  40                  45              


Val Lys Thr Phe Met Asp Met Asp Gln Asp Ser Glu Asp Glu Lys Gln 
    50                  55                  60                  


Gln Tyr Leu Pro Leu Ala Leu His Leu Ala Ser Glu Phe Phe Leu Arg 
65                  70                  75                  80  


Asn Pro Asn Lys Asp Val Arg Leu Leu Val Ala Cys Cys Leu Ala Asp 
                85                  90                  95      


Ile Phe Arg Ile Tyr Ala Pro Glu Ala Pro Tyr Thr Ser His Asp Lys 
            100                 105                 110         


Leu Lys Asp Ile Phe Leu Phe Ile Thr Arg Gln Leu Lys Gly Leu Glu 
        115                 120                 125             


Asp Thr Lys Ser Pro Gln Phe Asn Arg Tyr Phe Tyr Leu Leu Glu Asn 
    130                 135                 140                 


Leu Ala Trp Val Lys Ser Tyr Asn Ile Cys Phe Glu Leu Glu Asp Cys 
145                 150                 155                 160 


Asn Glu Ile Phe Ile Gln Leu Phe Arg Thr Leu Phe Ser Val Ile Asn 
                165                 170                 175     


Asn Ser His Asn Lys Lys Val Gln Met His Met Leu Asp Leu Met Ser 
            180                 185                 190         


Ser Ile Ile Met Glu Gly Asp Gly Val Thr Gln Glu Leu Leu Asp Ser 
        195                 200                 205             


Ile Leu Ile Asn Leu Ile Pro Ala His Lys Asn Leu Asn Lys Gln Ser 
    210                 215                 220                 


Phe Asp Leu Ala Lys Val Leu Leu Lys Arg Thr Val Gln Thr Ile Glu 
225                 230                 235                 240 


Ala Cys Ile Ala Asn Phe Phe Asn Gln Val Leu Val Leu Gly Arg Ser 
                245                 250                 255     


Ser Val Ser Asp Leu Ser Glu His Val Phe Asp Leu Ile Gln Glu Leu 
            260                 265                 270         


Phe Ala Ile Asp Pro His Leu Leu Leu Ser Val Met Pro Gln Leu Glu 
        275                 280                 285             


Phe Lys Leu Lys Ser Asn Asp Gly Glu Glu Arg Leu Ala Val Val Arg 
    290                 295                 300                 


Leu Leu Ala Lys Leu Phe Gly Ser Lys Asp Ser Asp Leu Ala Thr Gln 
305                 310                 315                 320 


Asn Arg Pro Leu Trp Gln Cys Phe Leu Gly Arg Phe Asn Asp Ile His 
                325                 330                 335     


Val Pro Val Arg Leu Glu Ser Val Lys Phe Ala Ser His Cys Leu Met 
            340                 345                 350         


Asn His Pro Asp Leu Ala Lys Asp Leu Thr Glu Tyr Leu Lys Val Arg 
        355                 360                 365             


Ser His Asp Pro Glu Glu Ala Ile Arg His Asp Val Ile Val Thr Ile 
    370                 375                 380                 


Ile Thr Ala Ala Lys Arg Asp Leu Ala Leu Val Asn Asp Gln Leu Leu 
385                 390                 395                 400 


Gly Phe Val Arg Glu Arg Thr Leu Asp Lys Arg Trp Arg Val Arg Lys 
                405                 410                 415     


Glu Ala Met Met Gly Leu Ala Gln Leu Tyr Lys Lys Tyr Cys Leu His 
            420                 425                 430         


Gly Glu Ala Gly Lys Glu Ala Ala Glu Lys Val Ser Trp Ile Lys Asp 
        435                 440                 445             


Lys Leu Leu His Ile Tyr Tyr Gln Asn Ser Ile Asp Asp Lys Leu Leu 
    450                 455                 460                 


Val Glu Lys Ile Phe Ala Gln Tyr Leu Val Pro His Asn Leu Glu Thr 
465                 470                 475                 480 


Glu Glu Arg Met Lys Cys Leu Tyr Tyr Leu Tyr Ala Ser Leu Asp Pro 
                485                 490                 495     


Asn Ala Val Lys Ala Leu Asn Glu Met Trp Lys Cys Gln Asn Met Leu 
            500                 505                 510         


Arg Ser His Val Arg Glu Leu Leu Asp Leu His Lys Gln Pro Thr Ser 
        515                 520                 525             


Glu Ala Asn Cys Ser Ala Met Phe Gly Lys Leu Met Thr Ile Ala Lys 
    530                 535                 540                 


Asn Leu Pro Asp Pro Gly Lys Ala Gln Asp Phe Val Lys Lys Phe Asn 
545                 550                 555                 560 


Gln Val Leu Gly Asp Asp Glu Lys Leu Arg Ser Gln Leu Glu Leu Leu 
                565                 570                 575     


Ile Ser Pro Thr Cys Ser Cys Lys Gln Ala Asp Ile Cys Val Arg Glu 
            580                 585                 590         


Ile Ala Arg Lys Leu Ala Asn Pro Lys Gln Pro Thr Asn Pro Phe Leu 
        595                 600                 605             


Glu Met Val Lys Phe Leu Leu Glu Arg Ile Ala Pro Val His Ile Asp 
    610                 615                 620                 


Ser Glu Ala Ile Ser Ala Leu Val Lys Leu Met Asn Lys Ser Ile Glu 
625                 630                 635                 640 


Gly Thr Ala Asp Asp Glu Glu Glu Gly Val Ser Pro Asp Thr Ala Ile 
                645                 650                 655     


Arg Ser Gly Leu Glu Leu Leu Lys Val Leu Ser Phe Thr His Pro Thr 
            660                 665                 670         


Ser Phe His Ser Ala Glu Thr Tyr Glu Ser Leu Leu Gln Cys Leu Arg 
        675                 680                 685             


Met Glu Asp Asp Lys Val Ala Glu Ala Ala Ile Gln Ile Phe Arg Asn 
    690                 695                 700                 


Thr Gly His Lys Ile Glu Thr Asp Leu Pro Gln Ile Arg Ser Thr Leu 
705                 710                 715                 720 


Ile Pro Ile Leu His Gln Lys Ala Lys Arg Gly Thr Pro His Gln Ala 
                725                 730                 735     


Lys Gln Ala Val His Cys Ile His Ala Ile Phe Thr Asn Lys Glu Val 
            740                 745                 750         


Gln Leu Ala Gln Ile Phe Glu Pro Leu Ser Arg Ser Leu Asn Ala Asp 
        755                 760                 765             


Val Pro Glu Gln Leu Ile Thr Pro Leu Val Ser Leu Gly His Ile Ser 
    770                 775                 780                 


Met Leu Ala Pro Asp Gln Phe Ala Ser Pro Met Lys Ser Val Val Ala 
785                 790                 795                 800 


Asn Phe Ile Val Lys Asp Leu Leu Met Asn Asp Arg Ser Thr Gly Glu 
                805                 810                 815     


Lys Asn Gly Lys Leu Trp Ser Pro Asp Glu Glu Val Ser Pro Glu Val 
            820                 825                 830         


Leu Ala Lys Val Gln Ala Ile Lys Leu Leu Val Arg Trp Leu Leu Gly 
        835                 840                 845             


Met Lys Asn Asn Gln Ser Lys Ser Ala Asn Ser Thr Leu Arg Leu Leu 
    850                 855                 860                 


Ser Ala Met Leu Val Ser Glu Gly Asp Leu Thr Glu Gln Lys Arg Ile 
865                 870                 875                 880 


Ser Lys Ser Asp Met Ser Arg Leu Arg Leu Ala Ala Gly Ser Ala Ile 
                885                 890                 895     


Met Lys Leu Ala Gln Glu Pro Cys Tyr His Glu Ile Ile Thr Pro Glu 
            900                 905                 910         


Gln Phe Gln Leu Cys Ala Leu Val Ile Asn Asp Glu Cys Tyr Gln Val 
        915                 920                 925             


Arg Gln Ile Phe Ala Gln Lys Leu His Lys Ala Leu Val Lys Leu Leu 
    930                 935                 940                 


Leu Pro Leu Glu Tyr Met Ala Ile Phe Ala Leu Cys Ala Lys Asp Pro 
945                 950                 955                 960 


Val Lys Glu Arg Arg Ala His Ala Arg Gln Cys Leu Leu Lys Asn Ile 
                965                 970                 975     


Ser Ile Arg Arg Glu Tyr Ile Lys Gln Asn Pro Met Ala Thr Glu Lys 
            980                 985                 990         


Leu Leu Ser Leu Leu Pro Glu Tyr  Val Val Pro Tyr Met  Ile His Leu 
        995                 1000                 1005             


Leu Ala  His Asp Pro Asp Phe  Thr Arg Ser Gln Asp  Val Asp Gln 
    1010                 1015                 1020             


Leu Arg  Asp Ile Lys Glu Cys  Leu Trp Phe Met Leu  Glu Val Leu 
    1025                 1030                 1035             


Met Thr  Lys Asn Glu Asn Asn  Ser His Ala Phe Met  Lys Lys Met 
    1040                 1045                 1050             


Ala Glu  Asn Ile Lys Leu Thr  Arg Asp Ala Gln Ser  Pro Asp Glu 
    1055                 1060                 1065             


Ser Lys  Thr Asn Glu Lys Leu  Tyr Thr Val Cys Asp  Val Ala Leu 
    1070                 1075                 1080             


Cys Val  Ile Asn Ser Lys Ser  Ala Leu Cys Asn Ala  Asp Ser Pro 
    1085                 1090                 1095             


Lys Asp  Pro Val Leu Pro Met  Lys Phe Phe Thr Gln  Pro Glu Lys 
    1100                 1105                 1110             


Asp Phe  Cys Asn Asp Lys Ser  Tyr Ile Ser Glu Glu  Thr Arg Val 
    1115                 1120                 1125             


Leu Leu  Leu Thr Gly Lys Pro  Lys Pro Ala Gly Val  Leu Gly Ala 
    1130                 1135                 1140             


Val Asn  Lys Pro Leu Ser Ala  Thr Gly Arg Lys Pro  Tyr Val Arg 
    1145                 1150                 1155             


Ser Thr  Gly Thr Glu Thr Gly  Ser Asn Ile Asn Val  Asn Ser Glu 
    1160                 1165                 1170             


Leu Asn  Pro Ser Thr Gly Asn  Arg Ser Arg Glu Gln  Ser Ser Glu 
    1175                 1180                 1185             


Ala Ala  Glu Thr Gly Val Ser  Glu Asn Glu Glu Asn  Pro Val Arg 
    1190                 1195                 1200             


Ile Ile  Ser Val Thr Pro Val  Lys Asn Ile Asp Pro  Val Lys Asn 
    1205                 1210                 1215             


Lys Glu  Ile Asn Ser Asp Gln  Ala Thr Gln Gly Asn  Ile Ser Ser 
    1220                 1225                 1230             


Asp Arg  Gly Lys Lys Arg Thr  Val Thr Ala Ala Gly  Ala Glu Asn 
    1235                 1240                 1245             


Ile Gln  Gln Lys Thr Asp Glu  Lys Val Asp Glu Ser  Gly Pro Pro 
    1250                 1255                 1260             


Ala Pro  Ser Lys Pro Arg Arg  Gly Arg Arg Pro Lys  Ser Glu Ser 
    1265                 1270                 1275             


Gln Gly  Asn Ala Thr Lys Asn  Asp Asp Leu Asn Lys  Pro Ile Asn 
    1280                 1285                 1290             


Lys Gly  Arg Lys Arg Ala Ala  Val Gly Gln Glu Ser  Pro Gly Gly 
    1295                 1300                 1305             


Leu Glu  Ala Gly Asn Ala Lys  Ala Pro Lys Leu Gln  Asp Leu Ala 
    1310                 1315                 1320             


Lys Lys  Ala Ala Pro Ala Glu  Arg Gln Ile Asp Leu  Gln Arg 
    1325                 1330                 1335         


<210>  76
<211>  2174
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Ser Ala Ser Phe Val Pro Asn Gly Ala Ser Leu Glu Asp Cys His 
1               5                   10                  15      


Cys Asn Leu Phe Cys Leu Ala Asp Leu Thr Gly Ile Lys Trp Lys Lys 
            20                  25                  30          


Tyr Val Trp Gln Gly Pro Thr Ser Ala Pro Ile Leu Phe Pro Val Thr 
        35                  40                  45              


Glu Glu Asp Pro Ile Leu Ser Ser Phe Ser Arg Cys Leu Lys Ala Asp 
    50                  55                  60                  


Val Leu Gly Val Trp Arg Arg Asp Gln Arg Pro Gly Arg Arg Glu Leu 
65                  70                  75                  80  


Trp Ile Phe Trp Trp Gly Glu Asp Pro Ser Phe Ala Asp Leu Ile His 
                85                  90                  95      


His Asp Leu Ser Glu Glu Glu Asp Gly Val Trp Glu Asn Gly Leu Ser 
            100                 105                 110         


Tyr Glu Cys Arg Thr Leu Leu Phe Lys Ala Val His Asn Leu Leu Glu 
        115                 120                 125             


Arg Cys Leu Met Asn Arg Asn Phe Val Arg Ile Gly Lys Trp Phe Val 
    130                 135                 140                 


Lys Pro Tyr Glu Lys Asp Glu Lys Pro Ile Asn Lys Ser Glu His Leu 
145                 150                 155                 160 


Ser Cys Ser Phe Thr Phe Phe Leu His Gly Asp Ser Asn Val Cys Thr 
                165                 170                 175     


Ser Val Glu Ile Asn Gln His Gln Pro Val Tyr Leu Leu Ser Glu Glu 
            180                 185                 190         


His Ile Thr Leu Ala Gln Gln Ser Asn Ser Pro Phe Gln Val Ile Leu 
        195                 200                 205             


Cys Pro Phe Gly Leu Asn Gly Thr Leu Thr Gly Gln Ala Phe Lys Met 
    210                 215                 220                 


Ser Asp Ser Ala Thr Lys Lys Leu Ile Gly Glu Trp Lys Gln Phe Tyr 
225                 230                 235                 240 


Pro Ile Ser Cys Cys Leu Lys Glu Met Ser Glu Glu Lys Gln Glu Asp 
                245                 250                 255     


Met Asp Trp Glu Asp Asp Ser Leu Ala Ala Val Glu Val Leu Val Ala 
            260                 265                 270         


Gly Val Arg Met Ile Tyr Pro Ala Cys Phe Val Leu Val Pro Gln Ser 
        275                 280                 285             


Asp Ile Pro Thr Pro Ser Pro Val Gly Ser Thr His Cys Ser Ser Ser 
    290                 295                 300                 


Cys Leu Gly Val His Gln Val Pro Ala Ser Thr Arg Asp Pro Ala Met 
305                 310                 315                 320 


Ser Ser Val Thr Leu Thr Pro Pro Thr Ser Pro Glu Glu Val Gln Thr 
                325                 330                 335     


Val Asp Pro Gln Ser Val Gln Lys Trp Val Lys Phe Ser Ser Val Ser 
            340                 345                 350         


Asp Gly Phe Asn Ser Asp Ser Thr Ser His His Gly Gly Lys Ile Pro 
        355                 360                 365             


Arg Lys Leu Ala Asn His Val Val Asp Arg Val Trp Gln Glu Cys Asn 
    370                 375                 380                 


Met Asn Arg Ala Gln Asn Lys Arg Lys Tyr Ser Ala Ser Ser Gly Gly 
385                 390                 395                 400 


Leu Cys Glu Glu Ala Thr Ala Ala Lys Val Ala Ser Trp Asp Phe Val 
                405                 410                 415     


Glu Ala Thr Gln Arg Thr Asn Cys Ser Cys Leu Arg His Lys Asn Leu 
            420                 425                 430         


Lys Ser Arg Asn Ala Gly Gln Gln Gly Gln Ala Pro Ser Leu Gly Gln 
        435                 440                 445             


Gln Gln Gln Ile Leu Pro Lys His Lys Thr Asn Glu Lys Gln Glu Lys 
    450                 455                 460                 


Ser Glu Lys Pro Gln Lys Arg Pro Leu Thr Pro Phe His His Arg Val 
465                 470                 475                 480 


Ser Val Ser Asp Asp Val Gly Met Asp Ala Asp Ser Ala Ser Gln Arg 
                485                 490                 495     


Leu Val Ile Ser Ala Pro Asp Ser Gln Val Arg Phe Ser Asn Ile Arg 
            500                 505                 510         


Thr Asn Asp Val Ala Lys Thr Pro Gln Met His Gly Thr Glu Met Ala 
        515                 520                 525             


Asn Ser Pro Gln Pro Pro Pro Leu Ser Pro His Pro Cys Asp Val Val 
    530                 535                 540                 


Asp Glu Gly Val Thr Lys Thr Pro Ser Thr Pro Gln Ser Gln His Phe 
545                 550                 555                 560 


Tyr Gln Met Pro Thr Pro Asp Pro Leu Val Pro Ser Lys Pro Met Glu 
                565                 570                 575     


Asp Arg Ile Asp Ser Leu Ser Gln Ser Phe Pro Pro Gln Tyr Gln Glu 
            580                 585                 590         


Ala Val Glu Pro Thr Val Tyr Val Gly Thr Ala Val Asn Leu Glu Glu 
        595                 600                 605             


Asp Glu Ala Asn Ile Ala Trp Lys Tyr Tyr Lys Phe Pro Lys Lys Lys 
    610                 615                 620                 


Asp Val Glu Phe Leu Pro Pro Gln Leu Pro Ser Asp Lys Phe Lys Asp 
625                 630                 635                 640 


Asp Pro Val Gly Pro Phe Gly Gln Glu Ser Val Thr Ser Val Thr Glu 
                645                 650                 655     


Leu Met Val Gln Cys Lys Lys Pro Leu Lys Val Ser Asp Glu Leu Val 
            660                 665                 670         


Gln Gln Tyr Gln Ile Lys Asn Gln Cys Leu Ser Ala Ile Ala Ser Asp 
        675                 680                 685             


Ala Glu Gln Glu Pro Lys Ile Asp Pro Tyr Ala Phe Val Glu Gly Asp 
    690                 695                 700                 


Glu Glu Phe Leu Phe Pro Asp Lys Lys Asp Arg Gln Asn Ser Glu Arg 
705                 710                 715                 720 


Glu Ala Gly Lys Lys His Lys Val Glu Asp Gly Thr Ser Ser Val Thr 
                725                 730                 735     


Val Leu Ser His Glu Glu Asp Ala Met Ser Leu Phe Ser Pro Ser Ile 
            740                 745                 750         


Lys Gln Asp Ala Pro Arg Pro Thr Ser His Ala Arg Pro Pro Ser Thr 
        755                 760                 765             


Ser Leu Ile Tyr Asp Ser Asp Leu Ala Val Ser Tyr Thr Asp Leu Asp 
    770                 775                 780                 


Asn Leu Phe Asn Ser Asp Glu Asp Glu Leu Thr Pro Gly Ser Lys Lys 
785                 790                 795                 800 


Ser Ala Asn Gly Ser Asp Asp Lys Ala Ser Cys Lys Glu Ser Lys Thr 
                805                 810                 815     


Gly Asn Leu Asp Pro Leu Ser Cys Ile Ser Thr Ala Asp Leu His Lys 
            820                 825                 830         


Met Tyr Pro Thr Pro Pro Ser Leu Glu Gln His Ile Met Gly Phe Ser 
        835                 840                 845             


Pro Met Asn Met Asn Asn Lys Glu Tyr Gly Ser Met Asp Thr Thr Pro 
    850                 855                 860                 


Gly Gly Thr Val Leu Glu Gly Asn Ser Ser Ser Ile Gly Ala Gln Phe 
865                 870                 875                 880 


Lys Ile Glu Val Asp Glu Gly Phe Cys Ser Pro Lys Pro Ser Glu Ile 
                885                 890                 895     


Lys Asp Phe Ser Tyr Val Tyr Lys Pro Glu Asn Cys Gln Ile Leu Val 
            900                 905                 910         


Gly Cys Ser Met Phe Ala Pro Leu Lys Thr Leu Pro Ser Gln Tyr Leu 
        915                 920                 925             


Pro Pro Ile Lys Leu Pro Glu Glu Cys Ile Tyr Arg Gln Ser Trp Thr 
    930                 935                 940                 


Val Gly Lys Leu Glu Leu Leu Ser Ser Gly Pro Ser Met Pro Phe Ile 
945                 950                 955                 960 


Lys Glu Gly Asp Gly Ser Asn Met Asp Gln Glu Tyr Gly Thr Ala Tyr 
                965                 970                 975     


Thr Pro Gln Thr His Thr Ser Phe Gly Met Pro Pro Ser Ser Ala Pro 
            980                 985                 990         


Pro Ser Asn Ser Gly Ala Gly Ile  Leu Pro Ser Pro Ser  Thr Pro Arg 
        995                 1000                 1005             


Phe Pro  Thr Pro Arg Thr Pro  Arg Thr Pro Arg Thr  Pro Arg Gly 
    1010                 1015                 1020             


Ala Gly  Gly Pro Ala Ser Ala  Gln Gly Ser Val Lys  Tyr Glu Asn 
    1025                 1030                 1035             


Ser Asp  Leu Tyr Ser Pro Ala  Ser Thr Pro Ser Thr  Cys Arg Pro 
    1040                 1045                 1050             


Leu Asn  Ser Val Glu Pro Ala  Thr Val Pro Ser Ile  Pro Glu Ala 
    1055                 1060                 1065             


His Ser  Leu Tyr Val Asn Leu  Ile Leu Ser Glu Ser  Val Met Asn 
    1070                 1075                 1080             


Leu Phe  Lys Asp Cys Asn Phe  Asp Ser Cys Cys Ile  Cys Val Cys 
    1085                 1090                 1095             


Asn Met  Asn Ile Lys Gly Ala  Asp Val Gly Val Tyr  Ile Pro Asp 
    1100                 1105                 1110             


Pro Thr  Gln Glu Ala Gln Tyr  Arg Cys Thr Cys Gly  Phe Ser Ala 
    1115                 1120                 1125             


Val Met  Asn Arg Lys Phe Gly  Asn Asn Ser Gly Leu  Phe Leu Glu 
    1130                 1135                 1140             


Asp Glu  Leu Asp Ile Ile Gly  Arg Asn Thr Asp Cys  Gly Lys Glu 
    1145                 1150                 1155             


Ala Glu  Lys Arg Phe Glu Ala  Leu Arg Ala Thr Ser  Ala Glu His 
    1160                 1165                 1170             


Val Asn  Gly Gly Leu Lys Glu  Ser Glu Lys Leu Ser  Asp Asp Leu 
    1175                 1180                 1185             


Ile Leu  Leu Leu Gln Asp Gln  Cys Thr Asn Leu Phe  Ser Pro Phe 
    1190                 1195                 1200             


Gly Ala  Ala Asp Gln Asp Pro  Phe Pro Lys Ser Gly  Val Ile Ser 
    1205                 1210                 1215             


Asn Trp  Val Arg Val Glu Glu  Arg Asp Cys Cys Asn  Asp Cys Tyr 
    1220                 1225                 1230             


Leu Ala  Leu Glu His Gly Arg  Gln Phe Met Asp Asn  Met Ser Gly 
    1235                 1240                 1245             


Gly Lys  Val Asp Glu Ala Leu  Val Lys Ser Ser Cys  Leu His Pro 
    1250                 1255                 1260             


Trp Ser  Lys Arg Asn Asp Val  Ser Met Gln Cys Ser  Gln Asp Ile 
    1265                 1270                 1275             


Leu Arg  Met Leu Leu Ser Leu  Gln Pro Val Leu Gln  Asp Ala Ile 
    1280                 1285                 1290             


Gln Lys  Lys Arg Thr Val Arg  Pro Trp Gly Val Gln  Gly Pro Leu 
    1295                 1300                 1305             


Thr Trp  Gln Gln Phe His Lys  Met Ala Gly Arg Gly  Ser Tyr Gly 
    1310                 1315                 1320             


Thr Asp  Glu Ser Pro Glu Pro  Leu Pro Ile Pro Thr  Phe Leu Leu 
    1325                 1330                 1335             


Gly Tyr  Asp Tyr Asp Tyr Leu  Val Leu Ser Pro Phe  Ala Leu Pro 
    1340                 1345                 1350             


Tyr Trp  Glu Arg Leu Met Leu  Glu Pro Tyr Gly Ser  Gln Arg Asp 
    1355                 1360                 1365             


Ile Ala  Tyr Val Val Leu Cys  Pro Glu Asn Glu Ala  Leu Leu Asn 
    1370                 1375                 1380             


Gly Ala  Lys Ser Phe Phe Arg  Asp Leu Thr Ala Ile  Tyr Glu Ser 
    1385                 1390                 1395             


Cys Arg  Leu Gly Gln His Arg  Pro Val Ser Arg Leu  Leu Thr Asp 
    1400                 1405                 1410             


Gly Ile  Met Arg Val Gly Ser  Thr Ala Ser Lys Lys  Leu Ser Glu 
    1415                 1420                 1425             


Lys Leu  Val Ala Glu Trp Phe  Ser Gln Ala Ala Asp  Gly Asn Asn 
    1430                 1435                 1440             


Glu Ala  Phe Ser Lys Leu Lys  Leu Tyr Ala Gln Val  Cys Arg Tyr 
    1445                 1450                 1455             


Asp Leu  Gly Pro Tyr Leu Ala  Ser Leu Pro Leu Asp  Ser Ser Leu 
    1460                 1465                 1470             


Leu Ser  Gln Pro Asn Leu Val  Ala Pro Thr Ser Gln  Ser Leu Ile 
    1475                 1480                 1485             


Thr Pro  Pro Gln Met Thr Asn  Thr Gly Asn Ala Asn  Thr Pro Ser 
    1490                 1495                 1500             


Ala Thr  Leu Ala Ser Ala Ala  Ser Ser Thr Met Thr  Val Thr Ser 
    1505                 1510                 1515             


Gly Val  Ala Ile Ser Thr Ser  Val Ala Thr Ala Asn  Ser Thr Leu 
    1520                 1525                 1530             


Thr Thr  Ala Ser Thr Ser Ser  Ser Ser Ser Ser Asn  Leu Asn Ser 
    1535                 1540                 1545             


Gly Val  Ser Ser Asn Lys Leu  Pro Ser Phe Pro Pro  Phe Gly Ser 
    1550                 1555                 1560             


Met Asn  Ser Asn Ala Ala Gly  Ser Met Ser Thr Gln  Ala Asn Thr 
    1565                 1570                 1575             


Val Gln  Ser Gly Gln Leu Gly  Gly Gln Gln Thr Ser  Ala Leu Gln 
    1580                 1585                 1590             


Thr Ala  Gly Ile Ser Gly Glu  Ser Ser Ser Leu Pro  Thr Gln Pro 
    1595                 1600                 1605             


His Pro  Asp Val Ser Glu Ser  Thr Met Asp Arg Asp  Lys Val Gly 
    1610                 1615                 1620             


Ile Pro  Thr Asp Gly Asp Ser  His Ala Val Thr Tyr  Pro Pro Ala 
    1625                 1630                 1635             


Ile Val  Val Tyr Ile Ile Asp  Pro Phe Thr Tyr Glu  Asn Thr Asp 
    1640                 1645                 1650             


Glu Ser  Thr Asn Ser Ser Ser  Val Trp Thr Leu Gly  Leu Leu Arg 
    1655                 1660                 1665             


Cys Phe  Leu Glu Met Val Gln  Thr Leu Pro Pro His  Ile Lys Ser 
    1670                 1675                 1680             


Thr Val  Ser Val Gln Ile Ile  Pro Cys Gln Tyr Leu  Leu Gln Pro 
    1685                 1690                 1695             


Val Lys  His Glu Asp Arg Glu  Ile Tyr Pro Gln His  Leu Lys Ser 
    1700                 1705                 1710             


Leu Ala  Phe Ser Ala Phe Thr  Gln Cys Arg Arg Pro  Leu Pro Thr 
    1715                 1720                 1725             


Ser Thr  Asn Val Lys Thr Leu  Thr Gly Phe Gly Pro  Gly Leu Ala 
    1730                 1735                 1740             


Met Glu  Thr Ala Leu Arg Ser  Pro Asp Arg Pro Glu  Cys Ile Arg 
    1745                 1750                 1755             


Leu Tyr  Ala Pro Pro Phe Ile  Leu Ala Pro Val Lys  Asp Lys Gln 
    1760                 1765                 1770             


Thr Glu  Leu Gly Glu Thr Phe  Gly Glu Ala Gly Gln  Lys Tyr Asn 
    1775                 1780                 1785             


Val Leu  Phe Val Gly Tyr Cys  Leu Ser His Asp Gln  Arg Trp Ile 
    1790                 1795                 1800             


Leu Ala  Ser Cys Thr Asp Leu  Tyr Gly Glu Leu Leu  Glu Thr Cys 
    1805                 1810                 1815             


Ile Ile  Asn Ile Asp Val Pro  Asn Arg Ala Arg Arg  Lys Lys Ser 
    1820                 1825                 1830             


Ser Ala  Arg Lys Phe Gly Leu  Gln Lys Leu Trp Glu  Trp Cys Leu 
    1835                 1840                 1845             


Gly Leu  Val Gln Met Ser Ser  Leu Pro Trp Arg Val  Val Ile Gly 
    1850                 1855                 1860             


Arg Leu  Gly Arg Ile Gly His  Gly Glu Leu Lys Asp  Trp Ser Cys 
    1865                 1870                 1875             


Leu Leu  Ser Arg Arg Asn Leu  Gln Ser Leu Ser Lys  Arg Leu Lys 
    1880                 1885                 1890             


Asp Met  Cys Arg Met Cys Gly  Ile Ser Ala Ala Asp  Ser Pro Ser 
    1895                 1900                 1905             


Ile Leu  Ser Ala Cys Leu Val  Ala Met Glu Pro Gln  Gly Ser Phe 
    1910                 1915                 1920             


Val Ile  Met Pro Asp Ser Val  Ser Thr Gly Ser Val  Phe Gly Arg 
    1925                 1930                 1935             


Ser Thr  Thr Leu Asn Met Gln  Thr Ser Gln Leu Asn  Thr Pro Gln 
    1940                 1945                 1950             


Asp Thr  Ser Cys Thr His Ile  Leu Val Phe Pro Thr  Ser Ala Ser 
    1955                 1960                 1965             


Val Gln  Val Ala Ser Ala Thr  Tyr Thr Thr Glu Asn  Leu Asp Leu 
    1970                 1975                 1980             


Ala Phe  Asn Pro Asn Asn Asp  Gly Ala Asp Gly Met  Gly Ile Phe 
    1985                 1990                 1995             


Asp Leu  Leu Asp Thr Gly Asp  Asp Leu Asp Pro Asp  Ile Ile Asn 
    2000                 2005                 2010             


Ile Leu  Pro Ala Ser Pro Thr  Gly Ser Pro Val His  Ser Pro Gly 
    2015                 2020                 2025             


Ser His  Tyr Pro His Gly Gly  Asp Ala Gly Lys Gly  Gln Ser Thr 
    2030                 2035                 2040             


Asp Arg  Leu Leu Ser Thr Glu  Pro His Glu Glu Val  Pro Asn Ile 
    2045                 2050                 2055             


Leu Gln  Gln Pro Leu Ala Leu  Gly Tyr Phe Val Ser  Thr Ala Lys 
    2060                 2065                 2070             


Ala Gly  Pro Leu Pro Asp Trp  Phe Trp Ser Ala Cys  Pro Gln Ala 
    2075                 2080                 2085             


Gln Tyr  Gln Cys Pro Leu Phe  Leu Lys Ala Ser Leu  His Leu His 
    2090                 2095                 2100             


Val Pro  Ser Val Gln Ser Asp  Glu Leu Leu His Ser  Lys His Ser 
    2105                 2110                 2115             


His Pro  Leu Asp Ser Asn Gln  Thr Ser Asp Val Leu  Arg Phe Val 
    2120                 2125                 2130             


Leu Glu  Gln Tyr Asn Ala Leu  Ser Trp Leu Thr Cys  Asp Pro Ala 
    2135                 2140                 2145             


Thr Gln  Asp Arg Arg Ser Cys  Leu Pro Ile His Phe  Val Val Leu 
    2150                 2155                 2160             


Asn Gln  Leu Tyr Asn Phe Ile  Met Asn Met Leu 
    2165                 2170                 


<210>  77
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  77

Asp Ser Leu Gln Leu Val Phe Gly Ile Glu Leu Met Lys Val Asp Pro 
1               5                   10                  15      


Ile Gly His Val Tyr Ile Phe Ala Thr 
            20                  25  


<210>  78
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Ala Thr Glu Lys Leu Leu Ser Leu Leu Pro Glu Phe Val Val Pro 
1               5                   10                  15      


Tyr Met Ile Tyr Leu Leu Ala His Asp Pro Asp Phe Thr Arg Ser Gln 
            20                  25                  30          


<210>  79
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  79

Pro His Ile Lys Ser Thr Val Ser Val Gln Ile Ile Ser Cys Gln Tyr 
1               5                   10                  15      


Leu Leu Gln Pro Val Lys His Glu Asp 
            20                  25  


<210>  80
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  80

Asp Ser Leu Gln Leu Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro 
1               5                   10                  15      


Ile Gly His Val Tyr Ile Phe Ala Thr 
            20                  25  


<210>  81
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Ala Thr Glu Lys Leu Leu Ser Leu Leu Pro Glu Tyr Val Val Pro 
1               5                   10                  15      


Tyr Met Ile His Leu Leu Ala His Asp Pro Asp Phe Thr Arg Ser Gln 
            20                  25                  30          


<210>  82
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  82

Pro His Ile Lys Ser Thr Val Ser Val Gln Ile Ile Pro Cys Gln Tyr 
1               5                   10                  15      


Leu Leu Gln Pro Val Lys His Glu Asp 
            20                  25  


