                         SEQUENCE LISTING

<110>  Ramot at Tel-Aviv University Ltd.
       Tel Hashomer Medical Research Infrastructure and Services 
       Ltd.
 
<120>  METHODS AND KITS FOR BREAST CANCER PROGNOSIS

<130>  2407100

<150>  US 62/157,723
<151>  2015-05-06

<150>  US 62/289,525
<151>  2016-02-01

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asn Asp Thr Val Thr Ile Arg Thr Arg Lys Phe Met Thr Asn Arg 
1               5                   10                  15      


Leu Leu Gln Arg Lys Gln Met Val Ile Asp Val Leu His Pro Gly Lys 
            20                  25                  30          


Ala Thr Val Pro Lys Thr Glu Ile Arg Glu Lys Leu Ala Lys Met Tyr 
        35                  40                  45              


Lys Thr Thr Pro Asp Val Ile Phe Val Phe Gly Phe Arg Thr His Phe 
    50                  55                  60                  


Gly Gly Gly Lys Thr Thr Gly Phe Gly Met Ile Tyr Asp Ser Leu Asp 
65                  70                  75                  80  


Tyr Ala Lys Lys Asn Glu Pro Lys His Arg Leu Ala Arg His Gly Leu 
                85                  90                  95      


Tyr Glu Lys Lys Lys Thr Ser Arg Lys Gln Arg Lys Glu Arg Lys Asn 
            100                 105                 110         


Arg Met Lys Lys Val Arg Gly Thr Ala Lys Ala Asn Val Gly Ala Gly 
        115                 120                 125             


Lys Lys Pro Lys Glu 
    130             


<210>  2
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Pro Leu Ser Leu Leu Lys Thr Ala Gln Asn His Pro Met Leu 
1               5                   10                  15      


Val Glu Leu Lys Asn Gly Glu Thr Tyr Asn Gly His Leu Val Ser Cys 
            20                  25                  30          


Asp Asn Trp Met Asn Ile Asn Leu Arg Glu Val Ile Cys Thr Ser Arg 
        35                  40                  45              


Asp Gly Asp Lys Phe Trp Arg Met Pro Glu Cys Tyr Ile Arg Gly Ser 
    50                  55                  60                  


Thr Ile Lys Tyr Leu Arg Ile Pro Asp Glu Ile Ile Asp Met Val Lys 
65                  70                  75                  80  


Glu Glu Val Val Ala Lys Gly Arg Gly Arg Gly Gly Leu Gln Gln Gln 
                85                  90                  95      


Lys Gln Gln Lys Gly Arg Gly Met Gly Gly Ala Gly Arg Gly Val Phe 
            100                 105                 110         


Gly Gly Arg Gly Arg Gly Gly Ile Pro Gly Thr Gly Arg Gly Gln Pro 
        115                 120                 125             


Glu Lys Lys Pro Gly Arg Gln Ala Gly Lys Gln 
    130                 135                 


<210>  3
<211>  1001
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Val Val Ile Arg Leu Leu Gly Leu Pro Phe Ile Ala Gly Pro 
1               5                   10                  15      


Val Asp Ile Arg His Phe Phe Thr Gly Leu Thr Ile Pro Asp Gly Gly 
            20                  25                  30          


Val His Ile Ile Gly Gly Glu Ile Gly Glu Ala Phe Ile Ile Phe Ala 
        35                  40                  45              


Thr Asp Glu Asp Ala Arg Arg Ala Ile Ser Arg Ser Gly Gly Phe Ile 
    50                  55                  60                  


Lys Asp Ser Ser Val Glu Leu Phe Leu Ser Ser Lys Ala Glu Met Gln 
65                  70                  75                  80  


Lys Thr Ile Glu Met Lys Arg Thr Asp Arg Val Gly Arg Gly Arg Pro 
                85                  90                  95      


Gly Ser Gly Thr Ser Gly Val Asp Ser Leu Ser Asn Phe Ile Glu Ser 
            100                 105                 110         


Val Lys Glu Glu Ala Ser Asn Ser Gly Tyr Gly Ser Ser Ile Asn Gln 
        115                 120                 125             


Asp Ala Gly Phe His Thr Asn Gly Thr Gly His Gly Asn Leu Arg Pro 
    130                 135                 140                 


Arg Lys Thr Arg Pro Leu Lys Ala Glu Asn Pro Tyr Leu Phe Leu Arg 
145                 150                 155                 160 


Gly Leu Pro Tyr Leu Val Asn Glu Asp Asp Val Arg Val Phe Phe Ser 
                165                 170                 175     


Gly Leu Cys Val Asp Gly Val Ile Phe Leu Lys His His Asp Gly Arg 
            180                 185                 190         


Asn Asn Gly Asp Ala Ile Val Lys Phe Ala Ser Cys Val Asp Ala Ser 
        195                 200                 205             


Gly Gly Leu Lys Cys His Arg Ser Phe Met Gly Ser Arg Phe Ile Glu 
    210                 215                 220                 


Val Met Gln Gly Ser Glu Gln Gln Trp Ile Glu Phe Gly Gly Asn Ala 
225                 230                 235                 240 


Val Lys Glu Gly Asp Val Leu Arg Arg Ser Glu Glu His Ser Pro Pro 
                245                 250                 255     


Arg Gly Ile Asn Asp Arg His Phe Arg Lys Arg Ser His Ser Lys Ser 
            260                 265                 270         


Pro Arg Arg Thr Arg Ser Arg Ser Pro Leu Gly Phe Tyr Val His Leu 
        275                 280                 285             


Lys Asn Leu Ser Leu Ser Ile Asp Glu Arg Asp Leu Arg Asn Phe Phe 
    290                 295                 300                 


Arg Gly Thr Asp Leu Thr Asp Glu Gln Ile Arg Phe Leu Tyr Lys Asp 
305                 310                 315                 320 


Glu Asn Arg Thr Arg Tyr Ala Phe Val Met Phe Lys Thr Leu Lys Asp 
                325                 330                 335     


Tyr Asn Thr Ala Leu Ser Leu His Lys Thr Val Leu Gln Tyr Arg Pro 
            340                 345                 350         


Val His Ile Asp Pro Ile Ser Arg Lys Gln Met Leu Lys Phe Ile Ala 
        355                 360                 365             


Arg Tyr Glu Lys Lys Arg Ser Gly Ser Leu Glu Arg Asp Arg Pro Gly 
    370                 375                 380                 


His Val Ser Gln Lys Tyr Ser Gln Glu Gly Asn Ser Gly Gln Lys Leu 
385                 390                 395                 400 


Cys Ile Tyr Ile Arg Asn Phe Pro Phe Asp Val Thr Lys Val Glu Val 
                405                 410                 415     


Gln Lys Phe Phe Ala Asp Phe Leu Leu Ala Glu Asp Asp Ile Tyr Leu 
            420                 425                 430         


Leu Tyr Asp Asp Lys Gly Val Gly Leu Gly Glu Ala Leu Val Lys Phe 
        435                 440                 445             


Lys Ser Glu Glu Gln Ala Met Lys Ala Glu Arg Leu Asn Arg Arg Arg 
    450                 455                 460                 


Phe Leu Gly Thr Glu Val Leu Leu Arg Leu Ile Ser Glu Ala Gln Ile 
465                 470                 475                 480 


Gln Glu Phe Gly Val Asn Phe Ser Val Met Ser Ser Glu Lys Met Gln 
                485                 490                 495     


Ala Arg Ser Gln Ser Arg Glu Arg Gly Asp His Ser His Leu Phe Asp 
            500                 505                 510         


Ser Lys Asp Pro Pro Ile Tyr Ser Val Gly Ala Phe Glu Asn Phe Arg 
        515                 520                 525             


His Gln Leu Glu Asp Leu Arg Gln Leu Asp Asn Phe Lys His Pro Gln 
    530                 535                 540                 


Arg Asp Phe Arg Gln Pro Asp Arg His Pro Pro Glu Asp Phe Arg His 
545                 550                 555                 560 


Ser Ser Glu Asp Phe Arg Phe Pro Pro Glu Asp Phe Arg His Ser Pro 
                565                 570                 575     


Glu Asp Phe Arg Arg Pro Arg Glu Glu Asp Phe Arg Arg Pro Ser Glu 
            580                 585                 590         


Glu Asp Phe Arg Arg Pro Trp Glu Glu Asp Phe Arg Arg Pro Pro Glu 
        595                 600                 605             


Asp Asp Phe Arg His Pro Arg Glu Glu Asp Trp Arg Arg Pro Leu Glu 
    610                 615                 620                 


Glu Asp Trp Arg Arg Pro Leu Glu Glu Asp Phe Arg Arg Ser Pro Thr 
625                 630                 635                 640 


Glu Asp Phe Arg Gln Leu Pro Glu Glu Asp Phe Arg Gln Pro Pro Glu 
                645                 650                 655     


Glu Asp Leu Arg Trp Leu Pro Glu Glu Asp Phe Arg Arg Pro Pro Glu 
            660                 665                 670         


Glu Asp Trp Arg Arg Pro Pro Glu Glu Asp Phe Arg Arg Pro Leu Gln 
        675                 680                 685             


Gly Glu Trp Arg Arg Pro Pro Glu Asp Asp Phe Arg Arg Pro Pro Glu 
    690                 695                 700                 


Glu Asp Phe Arg His Ser Pro Glu Glu Asp Phe Arg Gln Ser Pro Gln 
705                 710                 715                 720 


Glu His Phe Arg Arg Pro Pro Gln Glu His Phe Arg Arg Pro Pro Pro 
                725                 730                 735     


Glu His Phe Arg Arg Pro Pro Pro Glu His Phe Arg Arg Pro Pro Pro 
            740                 745                 750         


Glu His Phe Arg Arg Pro Pro Pro Glu His Phe Arg Arg Pro Pro Pro 
        755                 760                 765             


Glu His Phe Arg Arg Pro Pro Pro Glu His Phe Arg Arg Pro Pro Gln 
    770                 775                 780                 


Glu His Phe Arg Arg Pro Pro Gln Glu His Phe Arg Arg Ser Arg Glu 
785                 790                 795                 800 


Glu Asp Phe Arg His Pro Pro Asp Glu Asp Phe Arg Gly Pro Pro Asp 
                805                 810                 815     


Glu Asp Phe Arg His Pro Pro Asp Glu Asp Phe Arg Ser Pro Gln Glu 
            820                 825                 830         


Glu Asp Phe Arg Cys Pro Ser Asp Glu Asp Phe Arg Gln Leu Pro Glu 
        835                 840                 845             


Glu Asp Leu Arg Glu Ala Pro Glu Glu Asp Pro Arg Leu Pro Asp Asn 
    850                 855                 860                 


Phe Arg Pro Pro Gly Glu Asp Phe Arg Ser Pro Pro Asp Asp Phe Arg 
865                 870                 875                 880 


Ser His Arg Pro Phe Val Asn Phe Gly Arg Pro Glu Gly Gly Lys Phe 
                885                 890                 895     


Asp Phe Gly Lys His Asn Met Gly Ser Phe Pro Glu Gly Arg Phe Met 
            900                 905                 910         


Pro Asp Pro Lys Ile Asn Cys Gly Ser Gly Arg Val Thr Pro Ile Lys 
        915                 920                 925             


Ile Met Asn Leu Pro Phe Lys Ala Asn Val Asn Glu Ile Leu Asp Phe 
    930                 935                 940                 


Phe His Gly Tyr Arg Ile Ile Pro Asp Ser Val Ser Ile Gln Tyr Asn 
945                 950                 955                 960 


Glu Gln Gly Leu Pro Thr Gly Glu Ala Ile Val Ala Met Ile Asn Tyr 
                965                 970                 975     


Asn Glu Ala Met Ala Ala Ile Lys Asp Leu Asn Asp Arg Pro Val Gly 
            980                 985                 990         


Pro Arg Lys Val Lys Leu Thr Leu  Leu 
        995                 1000     


<210>  4
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly His Gln Gln Leu Tyr Trp Ser His Pro Arg Lys Phe Gly Gln 
1               5                   10                  15      


Gly Ser Arg Ser Cys Arg Val Cys Ser Asn Arg His Gly Leu Ile Arg 
            20                  25                  30          


Lys Tyr Gly Leu Asn Met Cys Arg Gln Cys Phe Arg Gln Tyr Ala Lys 
        35                  40                  45              


Asp Ile Gly Phe Ile Lys Leu Asp 
    50                  55      


<210>  5
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser Ser Glu Glu Gly Lys Leu Phe Val Gly Gly Leu Asn Phe Asn 
1               5                   10                  15      


Thr Asp Glu Gln Ala Leu Glu Asp His Phe Ser Ser Phe Gly Pro Ile 
            20                  25                  30          


Ser Glu Val Val Val Val Lys Asp Arg Glu Thr Gln Arg Ser Arg Gly 
        35                  40                  45              


Phe Gly Phe Ile Thr Phe Thr Asn Pro Glu His Ala Ser Val Ala Met 
    50                  55                  60                  


Arg Ala Met Asn Gly Glu Ser Leu Asp Gly Arg Gln Ile Arg Val Asp 
65                  70                  75                  80  


His Ala Gly Lys Ser Ala Arg Gly Thr Arg Gly Gly Gly Phe Gly Ala 
                85                  90                  95      


His Gly Arg Gly Arg Ser Tyr Ser Arg Gly Gly Gly Asp Gln Gly Tyr 
            100                 105                 110         


Gly Ser Gly Arg Tyr Tyr Asp Ser Arg Pro Gly Gly Tyr Gly Tyr Gly 
        115                 120                 125             


Tyr Gly Arg Ser Arg Asp Tyr Asn Gly Arg Asn Gln Gly Gly Tyr Asp 
    130                 135                 140                 


Arg Tyr Ser Gly Gly Asn Tyr Arg Asp Asn Tyr Asp Asn 
145                 150                 155         


<210>  6
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Asn Gly Tyr Thr Tyr Glu Asp Tyr Lys Asn Thr Ala Glu Trp 
1               5                   10                  15      


Leu Leu Ser His Thr Lys His Arg Pro Gln Val Ala Ile Ile Cys Gly 
            20                  25                  30          


Ser Gly Leu Gly Gly Leu Thr Asp Lys Leu Thr Gln Ala Gln Ile Phe 
        35                  40                  45              


Asp Tyr Gly Glu Ile Pro Asn Phe Pro Arg Ser Thr Val Pro Gly His 
    50                  55                  60                  


Ala Gly Arg Leu Val Phe Gly Phe Leu Asn Gly Arg Ala Cys Val Met 
65                  70                  75                  80  


Met Gln Gly Arg Phe His Met Tyr Glu Gly Tyr Pro Leu Trp Lys Val 
                85                  90                  95      


Thr Phe Pro Val Arg Val Phe His Leu Leu Gly Val Asp Thr Leu Val 
            100                 105                 110         


Val Thr Asn Ala Ala Gly Gly Leu Asn Pro Lys Phe Glu Val Gly Asp 
        115                 120                 125             


Ile Met Leu Ile Arg Asp His Ile Asn Leu Pro Gly Phe Ser Gly Gln 
    130                 135                 140                 


Asn Pro Leu Arg Gly Pro Asn Asp Glu Arg Phe Gly Asp Arg Phe Pro 
145                 150                 155                 160 


Ala Met Ser Asp Ala Tyr Asp Arg Thr Met Arg Gln Arg Ala Leu Ser 
                165                 170                 175     


Thr Trp Lys Gln Met Gly Glu Gln Arg Glu Leu Gln Glu Gly Thr Tyr 
            180                 185                 190         


Val Met Val Ala Gly Pro Ser Phe Glu Thr Val Ala Glu Cys Arg Val 
        195                 200                 205             


Leu Gln Lys Leu Gly Ala Asp Ala Val Gly Met Ser Thr Val Pro Glu 
    210                 215                 220                 


Val Ile Val Ala Arg His Cys Gly Leu Arg Val Phe Gly Phe Ser Leu 
225                 230                 235                 240 


Ile Thr Asn Lys Val Ile Met Asp Tyr Glu Ser Leu Glu Lys Ala Asn 
                245                 250                 255     


His Glu Glu Val Leu Ala Ala Gly Lys Gln Ala Ala Gln Lys Leu Glu 
            260                 265                 270         


Gln Phe Val Ser Ile Leu Met Ala Ser Ile Pro Leu Pro Asp Lys Ala 
        275                 280                 285             


Ser 
    


<210>  7
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Gly Val Glu Glu Val Ala Ala Ser Gly Ser His Leu Asn Gly 
1               5                   10                  15      


Asp Leu Asp Pro Asp Asp Arg Glu Glu Gly Ala Ala Ser Thr Ala Glu 
            20                  25                  30          


Glu Ala Ala Lys Lys Lys Arg Arg Lys Lys Lys Lys Ser Lys Gly Pro 
        35                  40                  45              


Ser Ala Ala Gly Glu Gln Glu Pro Asp Lys Glu Ser Gly Ala Ser Val 
    50                  55                  60                  


Asp Glu Val Ala Arg Gln Leu Glu Arg Ser Ala Leu Glu Asp Lys Glu 
65                  70                  75                  80  


Arg Asp Glu Asp Asp Glu Asp Gly Asp Gly Asp Gly Asp Gly Ala Thr 
                85                  90                  95      


Gly Lys Lys Lys Lys Lys Lys Lys Lys Lys Arg Gly Pro Lys Val Gln 
            100                 105                 110         


Thr Asp Pro Pro Ser Val Pro Ile Cys Asp Leu Tyr Pro Asn Gly Val 
        115                 120                 125             


Phe Pro Lys Gly Gln Glu Cys Glu Tyr Pro Pro Thr Gln Asp Gly Arg 
    130                 135                 140                 


Thr Ala Ala Trp Arg Thr Thr Ser Glu Glu Lys Lys Ala Leu Asp Gln 
145                 150                 155                 160 


Ala Ser Glu Glu Ile Trp Asn Asp Phe Arg Glu Ala Ala Glu Ala His 
                165                 170                 175     


Arg Gln Val Arg Lys Tyr Val Met Ser Trp Ile Lys Pro Gly Met Thr 
            180                 185                 190         


Met Ile Glu Ile Cys Glu Lys Leu Glu Asp Cys Ser Arg Lys Leu Ile 
        195                 200                 205             


Lys Glu Asn Gly Leu Asn Ala Gly Leu Ala Phe Pro Thr Gly Cys Ser 
    210                 215                 220                 


Leu Asn Asn Cys Ala Ala His Tyr Thr Pro Asn Ala Gly Asp Thr Thr 
225                 230                 235                 240 


Val Leu Gln Tyr Asp Asp Ile Cys Lys Ile Asp Phe Gly Thr His Ile 
                245                 250                 255     


Ser Gly Arg Ile Ile Asp Cys Ala Phe Thr Val Thr Phe Asn Pro Lys 
            260                 265                 270         


Tyr Asp Thr Leu Leu Lys Ala Val Lys Asp Ala Thr Asn Thr Gly Ile 
        275                 280                 285             


Lys Cys Ala Gly Ile Asp Val Arg Leu Cys Asp Val Gly Glu Ala Ile 
    290                 295                 300                 


Gln Glu Val Met Glu Ser Tyr Glu Val Glu Ile Asp Gly Lys Thr Tyr 
305                 310                 315                 320 


Gln Val Lys Pro Ile Arg Asn Leu Asn Gly His Ser Ile Gly Gln Tyr 
                325                 330                 335     


Arg Ile His Ala Gly Lys Thr Val Pro Ile Val Lys Gly Gly Glu Ala 
            340                 345                 350         


Thr Arg Met Glu Glu Gly Glu Val Tyr Ala Ile Glu Thr Phe Gly Ser 
        355                 360                 365             


Thr Gly Lys Gly Val Val His Asp Asp Met Glu Cys Ser His Tyr Met 
    370                 375                 380                 


Lys Asn Phe Asp Val Gly His Val Pro Ile Arg Leu Pro Arg Thr Lys 
385                 390                 395                 400 


His Leu Leu Asn Val Ile Asn Glu Asn Phe Gly Thr Leu Ala Phe Cys 
                405                 410                 415     


Arg Arg Trp Leu Asp Arg Leu Gly Glu Ser Lys Tyr Leu Met Ala Leu 
            420                 425                 430         


Lys Asn Leu Cys Asp Leu Gly Ile Val Asp Pro Tyr Pro Pro Leu Cys 
        435                 440                 445             


Asp Ile Lys Gly Ser Tyr Thr Ala Gln Phe Glu His Thr Ile Leu Leu 
    450                 455                 460                 


Arg Pro Thr Cys Lys Glu Val Val Ser Arg Gly Asp Asp Tyr 
465                 470                 475             


<210>  8
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Asp Ala Val Asp Ala Thr Met Glu Lys Leu Arg Ala Gln Cys Leu 
1               5                   10                  15      


Ser Arg Gly Ala Ser Gly Ile Gln Gly Leu Ala Arg Phe Phe Arg Gln 
            20                  25                  30          


Leu Asp Arg Asp Gly Ser Arg Ser Leu Asp Ala Asp Glu Phe Arg Gln 
        35                  40                  45              


Gly Leu Ala Lys Leu Gly Leu Val Leu Asp Gln Ala Glu Ala Glu Gly 
    50                  55                  60                  


Val Cys Arg Lys Trp Asp Arg Asn Gly Ser Gly Thr Leu Asp Leu Glu 
65                  70                  75                  80  


Glu Phe Leu Arg Ala Leu Arg Pro Pro Met Ser Gln Ala Arg Glu Ala 
                85                  90                  95      


Val Ile Ala Ala Ala Phe Ala Lys Leu Asp Arg Ser Gly Asp Gly Val 
            100                 105                 110         


Val Thr Val Asp Asp Leu Arg Gly Val Tyr Ser Gly Arg Ala His Pro 
        115                 120                 125             


Lys Val Arg Ser Gly Glu Trp Thr Glu Asp Glu Val Leu Arg Arg Phe 
    130                 135                 140                 


Leu Asp Asn Phe Asp Ser Ser Glu Lys Asp Gly Gln Val Thr Leu Ala 
145                 150                 155                 160 


Glu Phe Gln Asp Tyr Tyr Ser Gly Val Ser Ala Ser Met Asn Thr Asp 
                165                 170                 175     


Glu Glu Phe Val Ala Met Met Thr Ser Ala Trp Gln Leu 
            180                 185                 


<210>  9
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Thr Thr Ala Thr Met Ala Thr Ser Gly Ser Ala Arg Lys Arg 
1               5                   10                  15      


Leu Leu Lys Glu Glu Asp Met Thr Lys Val Glu Phe Glu Thr Ser Glu 
            20                  25                  30          


Glu Val Asp Val Thr Pro Thr Phe Asp Thr Met Gly Leu Arg Glu Asp 
        35                  40                  45              


Leu Leu Arg Gly Ile Tyr Ala Tyr Gly Phe Glu Lys Pro Ser Ala Ile 
    50                  55                  60                  


Gln Gln Arg Ala Ile Lys Gln Ile Ile Lys Gly Arg Asp Val Ile Ala 
65                  70                  75                  80  


Gln Ser Gln Ser Gly Thr Gly Lys Thr Ala Thr Phe Ser Ile Ser Val 
                85                  90                  95      


Leu Gln Cys Leu Asp Ile Gln Val Arg Glu Thr Gln Ala Leu Ile Leu 
            100                 105                 110         


Ala Pro Thr Arg Glu Leu Ala Val Gln Ile Gln Lys Gly Leu Leu Ala 
        115                 120                 125             


Leu Gly Asp Tyr Met Asn Val Gln Cys His Ala Cys Ile Gly Gly Thr 
    130                 135                 140                 


Asn Val Gly Glu Asp Ile Arg Lys Leu Asp Tyr Gly Gln His Val Val 
145                 150                 155                 160 


Ala Gly Thr Pro Gly Arg Val Phe Asp Met Ile Arg Arg Arg Ser Leu 
                165                 170                 175     


Arg Thr Arg Ala Ile Lys Met Leu Val Leu Asp Glu Ala Asp Glu Met 
            180                 185                 190         


Leu Asn Lys Gly Phe Lys Glu Gln Ile Tyr Asp Val Tyr Arg Tyr Leu 
        195                 200                 205             


Pro Pro Ala Thr Gln Val Val Leu Ile Ser Ala Thr Leu Pro His Glu 
    210                 215                 220                 


Ile Leu Glu Met Thr Asn Lys Phe Met Thr Asp Pro Ile Arg Ile Leu 
225                 230                 235                 240 


Val Lys Arg Asp Glu Leu Thr Leu Glu Gly Ile Lys Gln Phe Phe Val 
                245                 250                 255     


Ala Val Glu Arg Glu Glu Trp Lys Phe Asp Thr Leu Cys Asp Leu Tyr 
            260                 265                 270         


Asp Thr Leu Thr Ile Thr Gln Ala Val Ile Phe Cys Asn Thr Lys Arg 
        275                 280                 285             


Lys Val Asp Trp Leu Thr Glu Lys Met Arg Glu Ala Asn Phe Thr Val 
    290                 295                 300                 


Ser Ser Met His Gly Asp Met Pro Gln Lys Glu Arg Glu Ser Ile Met 
305                 310                 315                 320 


Lys Glu Phe Arg Ser Gly Ala Ser Arg Val Leu Ile Ser Thr Asp Val 
                325                 330                 335     


Trp Ala Arg Gly Leu Asp Val Pro Gln Val Ser Leu Ile Ile Asn Tyr 
            340                 345                 350         


Asp Leu Pro Asn Asn Arg Glu Leu Tyr Ile His Arg Ile Gly Arg Ser 
        355                 360                 365             


Gly Arg Tyr Gly Arg Lys Gly Val Ala Ile Asn Phe Val Lys Asn Asp 
    370                 375                 380                 


Asp Ile Arg Ile Leu Arg Asp Ile Glu Gln Tyr Tyr Ser Thr Gln Ile 
385                 390                 395                 400 


Asp Glu Met Pro Met Asn Val Ala Asp Leu Ile 
                405                 410     


<210>  10
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Asp Thr Ala Val Ala Asp Thr Arg Arg Leu Asn Ser Lys Pro 
1               5                   10                  15      


Gln Asp Leu Thr Asp Ala Tyr Gly Pro Pro Ser Asn Phe Leu Glu Ile 
            20                  25                  30          


Asp Ile Phe Asn Pro Gln Thr Val Gly Val Gly Arg Ala Arg Phe Thr 
        35                  40                  45              


Thr Tyr Glu Val Arg Met Arg Thr Asn Leu Pro Ile Phe Lys Leu Lys 
    50                  55                  60                  


Glu Ser Cys Val Arg Arg Arg Tyr Ser Asp Phe Glu Trp Leu Lys Asn 
65                  70                  75                  80  


Glu Leu Glu Arg Asp Ser Lys Ile Val Val Pro Pro Leu Pro Gly Lys 
                85                  90                  95      


Ala Leu Lys Arg Gln Leu Pro Phe Arg Gly Asp Glu Gly Ile Phe Glu 
            100                 105                 110         


Glu Ser Phe Ile Glu Glu Arg Arg Gln Gly Leu Glu Gln Phe Ile Asn 
        115                 120                 125             


Lys Ile Ala Gly His Pro Leu Ala Gln Asn Glu Arg Cys Leu His Met 
    130                 135                 140                 


Phe Leu Gln Glu Glu Ala Ile Asp Arg Asn Tyr Val Pro Gly Lys Ser 
145                 150                 155                 160 


Leu Ala Val Ser Cys Pro Gly Trp Ser Ala Val Ala 
                165                 170         


<210>  11
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ser Gly Gly Gly Val Ile Arg Gly Pro Ala Gly Asn Asn Asp Cys 
1               5                   10                  15      


Arg Ile Tyr Val Gly Asn Leu Pro Pro Asp Ile Arg Thr Lys Asp Ile 
            20                  25                  30          


Glu Asp Val Phe Tyr Lys Tyr Gly Ala Ile Arg Asp Ile Asp Leu Lys 
        35                  40                  45              


Asn Arg Arg Gly Gly Pro Pro Phe Ala Phe Val Glu Phe Glu Asp Pro 
    50                  55                  60                  


Arg Asp Ala Glu Asp Ala Val Tyr Gly Arg Asp Gly Tyr Asp Tyr Asp 
65                  70                  75                  80  


Gly Tyr Arg Leu Arg Val Glu Phe Pro Arg Ser Gly Arg Gly Thr Gly 
                85                  90                  95      


Arg Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Pro Arg Gly Arg Tyr 
            100                 105                 110         


Gly Pro Pro Ser Arg Arg Ser Glu Asn Arg Val Val Val Ser Gly Leu 
        115                 120                 125             


Pro Pro Ser Gly Ser Trp Gln Asp Leu Lys Asp His Met Arg Glu Ala 
    130                 135                 140                 


Gly Asp Val Cys Tyr Ala Asp Val Tyr Arg Asp Gly Thr Gly Val Val 
145                 150                 155                 160 


Glu Phe Val Arg Lys Glu Asp Met Thr Tyr Ala Val Arg Lys Leu Asp 
                165                 170                 175     


Asn Thr Lys Phe Arg Ser His Glu Gly Glu Thr Ala Tyr Ile Arg Val 
            180                 185                 190         


Lys Val Asp Gly Pro Arg Ser Pro Ser Tyr Gly Arg Ser Arg Ser Arg 
        195                 200                 205             


Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Asn Ser Arg Ser Arg 
    210                 215                 220                 


Ser Tyr Ser Pro Arg Arg Ser Arg Gly Ser Pro Arg Tyr Ser Pro Arg 
225                 230                 235                 240 


His Ser Arg Ser Arg Ser Arg Thr 
                245             


<210>  12
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Gly Arg Gly Gly Ala Ala Arg Pro Asn Gly Pro Ala Ala Gly 
1               5                   10                  15      


Asn Lys Ile Cys Gln Phe Lys Leu Val Leu Leu Gly Glu Ser Ala Val 
            20                  25                  30          


Gly Lys Ser Ser Leu Val Leu Arg Phe Val Lys Gly Gln Phe His Glu 
        35                  40                  45              


Tyr Gln Glu Ser Thr Ile Gly Ala Ala Phe Leu Thr Gln Thr Val Cys 
    50                  55                  60                  


Leu Asp Asp Thr Thr Val Lys Phe Glu Ile Trp Asp Thr Ala Gly Gln 
65                  70                  75                  80  


Glu Arg Tyr His Ser Leu Ala Pro Met Tyr Tyr Arg Gly Ala Gln Ala 
                85                  90                  95      


Ala Ile Val Val Tyr Asp Ile Thr Asn Thr Asp Thr Phe Ala Arg Ala 
            100                 105                 110         


Lys Asn Trp Val Lys Glu Leu Gln Arg Gln Ala Ser Pro Asn Ile Val 
        115                 120                 125             


Ile Ala Leu Ala Gly Asn Lys Ala Asp Leu Ala Ser Lys Arg Ala Val 
    130                 135                 140                 


Glu Phe Gln Glu Ala Gln Ala Tyr Ala Asp Asp Asn Ser Leu Leu Phe 
145                 150                 155                 160 


Met Glu Thr Ser Ala Lys Thr Ala Met Asn Val Asn Glu Ile Phe Met 
                165                 170                 175     


Ala Ile Ala Lys Lys Leu Pro Lys Asn Glu Pro Gln Asn Ala Thr Gly 
            180                 185                 190         


Ala Pro Gly Arg Asn Arg Gly Val Asp Leu Gln Glu Asn Asn Pro Ala 
        195                 200                 205             


Ser Arg Ser Gln Cys Cys Ser Asn 
    210                 215     


<210>  13
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Asn Gln Glu Lys Leu Ala Lys Leu Gln Ala Gln Val Arg Ile Gly 
1               5                   10                  15      


Gly Lys Gly Thr Ala Arg Arg Lys Lys Lys Val Val His Arg Thr Ala 
            20                  25                  30          


Thr Ala Asp Asp Lys Lys Leu Gln Ser Ser Leu Lys Lys Leu Ala Val 
        35                  40                  45              


Asn Asn Ile Ala Gly Ile Glu Glu Val Asn Met Ile Lys Asp Asp Gly 
    50                  55                  60                  


Thr Val Ile His Phe Asn Asn Pro Lys Val Gln Ala Ser Leu Ser Ala 
65                  70                  75                  80  


Asn Thr Phe Ala Ile Thr Gly His Ala Glu Ala Lys Pro Ile Thr Glu 
                85                  90                  95      


Met Leu Pro Gly Ile Leu Ser Gln Leu Gly Ala Asp Ser Leu Thr Ser 
            100                 105                 110         


Leu Arg Lys Leu Ala Glu Gln Phe Pro Arg Gln Val Leu Asp Ser Lys 
        115                 120                 125             


Ala Pro Lys Pro Glu Asp Ile Asp Glu Glu Asp Asp Asp Val Pro Asp 
    130                 135                 140                 


Leu Val Glu Asn Phe Asp Glu Ala Ser Lys Asn Glu Ala Asn 
145                 150                 155             


<210>  14
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Leu Phe Tyr Ser Phe Phe Lys Ser Leu Val Gly Lys Asp Val Val 
1               5                   10                  15      


Val Glu Leu Lys Asn Asp Leu Ser Ile Cys Gly Thr Leu His Ser Val 
            20                  25                  30          


Asp Gln Tyr Leu Asn Ile Lys Leu Thr Asp Ile Ser Val Thr Asp Pro 
        35                  40                  45              


Glu Lys Tyr Pro His Met Leu Ser Val Lys Asn Cys Phe Ile Arg Gly 
    50                  55                  60                  


Ser Val Val Arg Tyr Val Gln Leu Pro Ala Asp Glu Val Asp Thr Gln 
65                  70                  75                  80  


Leu Leu Gln Asp Ala Ala Arg Lys Glu Ala Leu Gln Gln Lys Gln 
                85                  90                  95  


<210>  15
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Met Cys Gly Ala Pro Ser Ala Thr Gln Pro Ala Thr Ala Glu Thr 
1               5                   10                  15      


Gln His Ile Ala Asp Gln Val Arg Ser Gln Leu Glu Glu Lys Glu Asn 
            20                  25                  30          


Lys Lys Phe Pro Val Phe Lys Ala Val Ser Phe Lys Ser Gln Val Val 
        35                  40                  45              


Ala Gly Thr Asn Tyr Phe Ile Lys Val His Val Gly Asp Glu Asp Phe 
    50                  55                  60                  


Val His Leu Arg Val Phe Gln Ser Leu Pro His Glu Asn Lys Pro Leu 
65                  70                  75                  80  


Thr Leu Ser Asn Tyr Gln Thr Asn Lys Ala Lys His Asp Glu Leu Thr 
                85                  90                  95      


Tyr Phe 
        


