                         SEQUENCE LISTING

<110>  FRED HUTCHINSON CANCER RESEARCH CENTER
 
<120>  MODIFIED STEM CELLS AND USES THEREOF

<130>  F053-0021PCT

<140>  PCT/US 16/030283
<141>  2016-04-29

<150>  US 62/154573
<151>  2015-04-29

<160>  53    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STREP-TAG II

<400>  1

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  2
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Myc tag

<400>  2

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  3
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V5 tag

<400>  3

Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAG Tag

<400>  4

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  5
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  5

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  6

Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  7

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser 
1               5                   10      


<210>  8
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Core Hinge Region

<400>  8

Cys Pro Pro Cys Pro 
1               5   


<210>  9
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  STREP-TAG II Coding Sequence

<400>  9
tggagccacc cgcagttcga aaaa                                              24


<210>  10
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  10

Gly Gly Ser Gly Ser Gly 
1               5       


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Xpress tag

<400>  11

Asp Leu Tyr Asp Asp Asp Asp Lys 
1               5               


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Avi Tag

<400>  12

Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15  


<210>  13
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Calmodulin Tag

<400>  13

Lys Arg Arg Trp Lys Lys Asn Phe Ile Ala Val Ser Ala Ala Asn Arg 
1               5                   10                  15      


Phe Lys Lys Ile Ser Ser Ser Gly Ala Leu 
            20                  25      


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA Tag

<400>  14

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  15
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Soft Tag 1

<400>  15

Ser Leu Ala Glu Leu Leu Asn Ala Gly Leu Gly Gly Ser 
1               5                   10              


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Softag 3

<400>  16

Thr Gln Asp Pro Ser Arg Val Gly 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Strep-Tag

<400>  17

Trp Arg His Pro Gln Phe Gly Gly 
1               5               


<210>  18
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Tag of a Minimal Chelation Site

<400>  18

His Gly Gly His His Gly 
1               5       


<210>  19
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker + Tag

<400>  19

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe 
1               5                   10                  15      


Glu Lys 
        


<210>  20
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker + Tag

<400>  20

Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  21
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker + Tag

<400>  21

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe 
1               5                   10                  15      


Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Trp Ser His 
            20                  25                  30          


Pro Gln Phe Glu Lys 
        35          


<210>  22
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker + Tag

<400>  22

Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Ser 
        35          


<210>  23
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker + Tag

<400>  23

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Trp Ser His Pro Gln Phe 
1               5                   10                  15      


Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Trp Ser His 
            20                  25                  30          


Pro Gln Phe Glu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Trp 
        35                  40                  45              


Ser His Pro Gln Phe Glu Lys 
    50                  55  


<210>  24
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker + Tag

<400>  24

Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Ser Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser 
    50                  55  


<210>  25
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  25

Gly Gly Gly Gly Ser 
1               5   


<210>  26
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  26

Gly Gly Gly Ser 
1               


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  27

Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  28

Gly Gly Gly Ser Gly Gly Ser 
1               5           


<210>  29
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  29

Gly Ser Gly Ser Gly 
1               5   


<210>  30
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Long spacer

<400>  30

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  31
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intermediate Spacer

<400>  31

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gln Pro Arg 
1               5                   10                  15      


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
            20                  25                  30          


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        35                  40                  45              


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    50                  55                  60                  


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
65                  70                  75                  80  


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
                85                  90                  95      


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            100                 105                 110         


Leu Ser Leu Ser Leu Gly Lys 
        115                 


<210>  32
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         


Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu 
        195                 200                 205             


Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys 
    210                 215                 220                 


Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu 
225                 230                 235                 240 


Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met 
                245                 250                 255     


Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala 
            260                 265                 270         


His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val 
        275                 280                 285             


Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His 
    290                 295                 300                 


Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro 
305                 310                 315                 320 


Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala 
                325                 330                 335     


Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly 
            340                 345                 350         


Ile Gly Leu Phe Met 
        355         


<210>  33
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  33

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  34
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  34

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210>  35
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  35

Glu Leu Lys Thr Pro Leu Gly Asp Thr His Thr Cys Pro Arg Cys Pro 
1               5                   10                  15      


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
            20                  25                  30          


Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro 
        35                  40                  45              


Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
    50                  55                  60      


<210>  36
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  36

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
1               5                   10          


<210>  37
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Human IgG4

<400>  37

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10          


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Human IgG4

<400>  38

Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   


<210>  39
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Human IgG4

<400>  39

Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10  


<210>  40
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Human IgG4

<400>  40

Glu Val Val Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10              


<210>  41
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  41

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  42
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge/Spacer

<400>  42

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10          


<210>  43
<211>  110
<212>  PRT
<213>  Pan troglodytes

<400>  43

Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  44
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  44

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
            100                 105         


<210>  45
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
1               5                   10                  15      


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25              


<210>  46
<211>  24
<212>  PRT
<213>  Thosea asigna

<400>  46

Leu Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
1               5                   10                  15      


Val Glu Glu Asn Pro Gly Pro Arg 
            20                  


<210>  47
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB

<400>  47

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  48
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD3 Zeta

<400>  48

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  49
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITAM1

<400>  49

Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
1               5                   10                  15      


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            20                  25                  


<210>  50
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITAM2

<400>  50

Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
1               5                   10                  15      


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
            20                  25                  


<210>  51
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ITAM3

<400>  51

Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
1               5                   10                  15      


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
            20                  25                  


<210>  52
<211>  462
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of CD3 Zeta and a portion of the 4-1BB intracellular 
       signaling domain

<400>  52
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactgcggg tgaagttcag cagaagcgcc gacgcccctg cctaccagca gggccagaat      180

cagctgtaca acgagctgaa cctgggcaga agggaagagt acgacgtcct ggataagcgg      240

agaggccggg accctgagat gggcggcaag cctcggcgga agaaccccca ggaaggcctg      300

tataacgaac tgcagaaaga caagatggcc gaggcctaca gcgagatcgg catgaagggc      360

gagcggaggc ggggcaaggg ccacgacggc ctgtatcagg gcctgtccac cgccaccaag      420

gatacctacg acgccctgca catgcaggcc ctgcccccaa gg                         462


<210>  53
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CD3 Zeta and a portion of the 4-1BB intracellular 
       signaling domain

<400>  53

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
        35                  40                  45              


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
    50                  55                  60                  


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
65                  70                  75                  80  


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
                85                  90                  95      


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
            100                 105                 110         


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
        115                 120                 125             


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
    130                 135                 140                 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
145                 150                 


