                         SEQUENCE LISTING

<110>  KANSAS STATE UNVERSITY RESEARCH FOUNDATION
 
<120>  PORCINE PESTVIRUS, VACCINES, AND ASSAYS

<130>  47343-PCT

<150>  US 62/155,004
<151>  2015-04-30

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  11276
<212>  DNA
<213>  Porcine pestivirus 1 strain 000515

<300>
<308>  GenBank/KR011347.1
<309>  2015-07-29
<313>  (1)..(11276)

<400>  1
gcagatatcg gtggtggacc tgggggttgg gctcaccgtg ccccttcatg gggtagacct       60

cactgcttga tagagtgccg gcggatgcct caggtaagag tataaaatcc gttgttcact      120

aacatggaaa aacagattgc atactattta aaaaaagaaa aacaaagaaa tgggtggaca      180

gaactggtgg taggagaaag ctatacgaaa ataaccacac tctctggaaa aacctatcga      240

ggtacttggg aaatggagaa gcggtcaaat ccttatggaa cctaccttcc cagacctagt      300

cctcaacagc tcactgccat acacccccac cccgtggtga attgtaaggt gatggagtac      360

aaggagaagg accctaatta tggcgattgc ccgaatacga atggggtgtt tatcgatgaa      420

aagggtagaa ggctgagtag ccccccattg ggtatctgga agataagatt ggattatggt      480

gatctggtaa atatagacag accaattcct gctagtggga aaaactctta tcgagtcgag      540

acctgtagcg gagagctggc caccgtaaca ctgacacacg atagggtact tgtggaagac      600

tacaggggac tttaccaatg gaaacccaac tgtgaaggaa tggtgctcta cgtgaaaact      660

tgttctgatt gggcagacca ggtggaaaaa caggagaagg aaagcccccc gaaacctcag      720

cgaccaccaa ggcgggatcc ccgaaaagga ttacaaccac aagtccccaa agaaactgag      780

gtcacagaaa agaagagaca acctagtgtc actttagtgt cagggggaca gaaagcccag      840

gtcatctata aaggtaagac taaaaacaaa aagacaccgg atggagtcta taagtatcca      900

ggagctagag aaggggatgt agtaaaggtc aggaagatgc tgaagaactg gcatatagcc      960

ttagtaatgt acttaatata tattataact ccaagttttg ccaaggtcca gtggttttta     1020

aaggatgaaa attcgtcagg aattaaccag gtattatgga gaagacagat caacagatcc     1080

ctacatgggg agtggcctaa ccagatttgc catggcatgc caaatgaaac tatcactgac     1140

gaggaattac gcagtttagg aatgatagat acaagcccta gaacaaacta tacttgctgt     1200

cagttgcaat atcatgaatg gaagaaacat ggttggtgca attacccaca aaaacaggct     1260

tggatcagga gaatagcgac cctgcaagcc aacctcaccg gagcttataa gggacctgag     1320

tgtgctgtca tctgtcgatt taacggcacc tataacattg tgagacaggc cagagacgag     1380

gtgagtccac tgacagggtg taaggaaggg cacccttttc tattttctga ggaaaggtcc     1440

gacacctcgt gcttgaggcc gccctccact agttgggtga gaccagtgaa aatggatgag     1500

gcatcgatgg ctgacagctt cgcccacggg gtcgataagg ccataatatt aatcagaaaa     1560

ggggcatcgg gaattatcaa tttcctagac actattggga gatggttacc ggtgactgaa     1620

gcagctatag taccatattg cgaaacctac actgtgacag ggatgtatgt ccatgtaaag     1680

aattgtcttc ctagagggct acctaagcat tcaaaaataa tctccccaac aatgatatac     1740

ctgggggaag gcgacccggc ccataacatc cagcacttat tcggctcagg tatagcaaag     1800

tgggtcctag tcttactcgg gatcctgggt gagtggtatg gagaattagc ctctacaatt     1860

tacttactac ttgagtatgg gtctgagtgg ttggaacatg aaagtctggt cacagaaggg     1920

ctgttcccgg gtattaatat tacaatagac ctcccggcta gccacacagt acctggttgg     1980

gtgtgggtcg cgggccagtg ggtatgcgtg aagccagatt ggtggcccac acaggtctgg     2040

atcgaaaccg tggtggcaga agcctggcac atattaaaaa tcctagcatc ggccttggtg     2100

aatatagtca ctgcatttgt gaacctagaa ctggtctatt tggttataat actagtcaag     2160

atatcaaagg ggaacttgat aggtgccata ttatggtgcc tgttactgtc tggggctgag     2220

gggtcgtgtc taaaaaggca agactactac aacgtccagc tagttgtcga agaaaagact     2280

ggcgtagaaa aacggtctat aatgggcaag tggacagtga taactaagga aggccaggaa     2340

ccaagattaa tggagcagat aaagatggtg tcaaataaaa gtgtgacaga aatttactgc     2400

tataatgggc tcaatactag cagttggggg cggcaaccga caaaacagag agggtgtagc     2460

caaatagtgc cctattggcc tggtgacaat gtcctagaag aacaatacta tagcacgggt     2520

tactgggtga acgcaacagg cagctgtcag cttagggaag gcgtatggct atcaagaaag     2580

ggcaatgtac ggtgccagcg taatggcaca tccttgatac tgcaactggc gataaaagaa     2640

gacaatgaca ctatggaaat accgtgcgac ccagtggaaa cagaaagcat gggtcctgtg     2700

gcacagggta cttgcgtgta cagctgggca gtcgctccaa gagggtggta ctataatagg     2760

aaagatggtt actggctgca gtatataaag aaagatgact accagtactg gactaaaatg     2820

cctactgcct cgtctgcagc aacaatgtac cgccatctgc ttcctttatt ggtggcctgc     2880

ctcatgggcg gcaggatatc ggtgtggatt gtcgcaatgc tcctatctct acaggtggaa     2940

gctagtgaag tgggcactaa gcaactggcc gtcacactaa ctctatggaa aatggactgg     3000

acggaattac tcttctacat catcataatg ttagccgtca aggaagacct cataaagaaa     3060

atagtgactg caagccttgt aaccttgaaa aatagtccag tagccttgag ctttctcatt     3120

gtactcaggc ttgtgggggg cagcgaagca ctcccagtgg gcttactact agaaaaaatg     3180

tgcatagacc aaccagagtt tggaactccc ttcttgatct acttgtggga caattggaaa     3240

tggactgtcc tagtcagttt ctctgcacta aaccatgaaa aaactataag actggcaagg     3300

aagctgctat tggcaacaca tataacagcg ctcacgttga ctggtctaag tgattcaatt     3360

ttttatatca tgcttataat gactaaccta ttaataaaga cattcatata tctattgggg     3420

gtcagcataa attgggttga gaaagaaaaa aagaggttac tagtaaagag gaagctaata     3480

tataagaaaa ccgcaatctg taatcaggac gagaatgaat tggagaacaa gttcaacaag     3540

atatccgtta atgcggactt caccccatgc aagcttgaat tattacaact actcagggct     3600

tttttagttt ccctatgttt ttcctactac aaacccctcc tgtatgcaga gactacccta     3660

actgtcatag taattggcgt gcaggaatac aatgtggcaa tggcacgtgg gcgaagcgtg     3720

gttcataaat tattagccat ggcatattat gtatatggtc acatacaggg caatatgttc     3780

cagctcgcca gtatccagtg cctgttgtca agcccaagga aaatcatgaa acatatgata     3840

gaaaacccaa tccttaggaa gttctggcaa ggtgaaacag aactctacaa ccagggtgtc     3900

aatcaatcta aaatagtaaa cccaaagaaa atcgggctgg aagaattaca taaaggtatg     3960

tgcggcctac caactgtagt acaaaatttg gtcatatatg caaagaagaa tgactctctt     4020

atattaggag aattgggcta tccccctggg gatctcacca gtgatgggtg ggaaatttta     4080

ggccccggca gaattccgaa gatcaccaat gttgagtctg ccaagatgga cttactctcc     4140

aaactcatga cctttctggg gattgaaagc tcaagagtcc ccagaacccc aatccactca     4200

acaaggaaat tactgaagat agtgagaggc ttggaaactg ggtgggggta cactcacgca     4260

ggggggatta gtagtgcaaa acatgtcaca ggtgaaaaaa acttaatgac ccacatggag     4320

ggcaggaagg gcaagtacat cttacaatcc caagaacatg gtgccgatga ggtagagtat     4380

ggagtaaaaa ctgaccaaag agcgcccgac aacgccttat gttactgctt taaccctgaa     4440

gccacaaaca taaagggaga aacaggggcc atggtgttca tgaaaaagat aggaaaaaaa     4500

tggacccttg taacatcaga tggtaacaaa gcctactata atgtaaacaa tctgaaaggg     4560

tggtccggac taccaataat gctgcactcc accggggcca tagtagggag gattaaatcg     4620

gcatattcag atgaaaacga cttggtggag gagcttatcg actccaggac tatcagtaag     4680

agtaatgaga caaacctgaa ccaccttatt aaggaattgg cagatatgcg gaggggggag     4740

ttccgctcaa ttacccttgg aacgggtgct gggaaaacca cagaactgcc caggcaatat     4800

ctcacaacag taggtacaca taaatctgta ctagtcctgg tccctctaaa agcacccgcc     4860

gaaagtgtct gccgcttcat gaggtctaag taccctacca ttaacttttc tttaagagtg     4920

ggagagcgga aagagggaga cgtgagcagc ggtatcacct atgctactta cggattttgc     4980

tgccagctta acctagttca actcaaagag tggatatcca ggtactcaat ggtgtttttc     5040

gacgaatacc acacggcaac cccggaacag atagctataa taagcaagat ccacgcactg     5100

aaagttaaaa ccaggatagt ggccatgtca gcaactcccc cgggcaccgt gacaactgaa     5160

ggcaggaaat ttgacatcga agaagtcggg gttgccacaa tagagaaggg agaggaacca     5220

aaaagggggc gtgtagcggt cgccggcatg caggtcccgt tggaagattt gacagggaag     5280

aattgcctgg tattcgtggc aaccaaagaa gccgcggaga cggaggccaa agagctgcgt     5340

gccagaggaa tcaacgcaac ctattactat tcaggtatag accccaaaac tctggaacat     5400

gggatgacca accagccata ttgtattgtg gccacaaatg ccatcgaatc gggcataacc     5460

tgtcctgatt tagatgtggt catagatacc atgcagaaat acgaaaaggt agtgaatttc     5520

tcagcaaaga tgcccttgat tgtcacatca ttagtaaaga aaaaaatcac cagggaagaa     5580

cagggccaga ggaaaggtcg agtgggcagg caaaagaagg gaaaatatta ttatccttcg     5640

ggggtggtac cgaatggatc aaaagacctt agctatctaa tcctgcaggc ccaagagtat     5700

ggtgtcctgg aacaagttaa cataacagag tacttcataa taatgaatga ggactggggt     5760

ctttacgacg tagatgaggt agaagtgaga atactggaga gaatgaacaa ggaaatcttg     5820

cttccgctag gcatcgtgga gaagcaaatc ctggaaagaa gtactcaccc ggaaaaggtg     5880

gcactgttgt ataataaatt agtacaaaaa agccccatag tataccctag agtgcaggag     5940

ggtgaggtta gtaaggaata taatacccac aatctggccg tgtatgacaa gctaaaagat     6000

gtcaatccac aggccattta tgtcctagca gaggaggaaa gagccacaga gatgatgggc     6060

ctcgagttcg aacaagatcc atccgactta caggattcag tagtccaact ttgtgaagac     6120

atcaagaggt atacaaaact ctctgggatc actgagaaat tactagtagg tacaatggtg     6180

gggtacatag gatataaagc cctaaccaga aaccacgtgc cctgggttag taaagagtat     6240

tgctatgagc tgactgattc acctgatact tacgagaact catttgcacc tttagatgtc     6300

gatatccaaa accccggtga aagtaaacac ccagaacaac tggcagatca tcaactgagg     6360

caattactgg agactgggag agacaaggca atcgacttcc taaaaggagt ccgcgagttc     6420

actagtgggg ctataaatag cccaaaagca ctgagtatat gggagaaaat atatcagtac     6480

ttgaggaaac atcagggcga gatcatctca tcagcggcgt ggggcagcgc aacggccctt     6540

cacgacagta tcaaatctag gttaggggat gaggtagcca ccgcagtaat aattcttaag     6600

tatttagcat ttggtgaaag agaattgtcc ggactgacca ggcaagtctt aattgacatc     6660

atagtatatt atatagtcaa caagccccgg ttcgaaggag atgactatgc gaagagaaag     6720

gggagaagac tggtcattga agtcttgatg ggggcactgg caacttatgc agtgtcaaat     6780

ttttggggcg tgtctgttaa taagatacta caaccaatat ctgattatct accttatgct     6840

accgccactt tagctttcct tcgcccaact ttcatggaat cagcggtggt ggtcgcttct     6900

tctatttaca gagcctttct ctccattaaa catgcagaaa acaggagtct cgttacgcag     6960

gtcgcctctg ccgctcttga agtcatgggt ttgaccccag tatcagctgg cctaggcgtc     7020

ctgctggggc ttgggctgtg tgtgctccat atgaacattg acaagaatga ggagaagagg     7080

acactgatat tgaaaatgtt tgttaaaaac tttatagacc aggcagcact agatgagtta     7140

gacaaactgg agccagaaaa aataatcctc tcattgttgg agggcatcca aacttgcaca     7200

aacccaatca gagctattat gattttatac agagtgtatt acaagggaga atcgtttaca     7260

gaagccttgt ctaagatggc tggaaagtcc ctcatagtga tggtcattgt cgagttcctg     7320

gaactgacgg gccagaccca aggggggtat atagacctta gtgccaatct gctgactttt     7380

cttttggaaa aactgaaaaa gatgaccaac ctcgccatag gggaggccag aaaggcctta     7440

ctccctattc catacttgta ctgtgaaacc tggcagtctg acgccagaat caaggccccg     7500

gaatcctacg accaggtggc agtggaatgc agatgcggtg cttccgcaag atactccttt     7560

caccacgggg ttcatgaggt attggaagaa aaaatgacca agtggtgtaa gaacttcttc     7620

ctatggggac ctaatttttc caacccggat ccaaagagga tgacattcta tgaatgcggt     7680

caagcaagaa agtgtcccgt aatcataatg ggcgaagaca taacctttgg taaatatggt     7740

atatatgtca aatttggcca cgggcctgat gggagaagat taataagggg caccacccat     7800

gccaccatca gcagggagga gctgctagaa atcctaacgg ccccaagtca agtagcaata     7860

ggtaaagtca agctgacaga ttactgcaat caaaagggaa tgatagatag gaaactggct     7920

gtacttgaag gtgacaaaat acatttctgg aaagcacatc gtgggtccaa gatcacggat     7980

caactcacca ttgagagtct gacagatgac ttggggtcgg aaatcaggga tatcacatgg     8040

gagctgtaca caggtgggac atgcaccgta aaaggaatat cccttaggtc gtgcgcacca     8100

gggcaacgaa acaaggccac ggttttgtgt gattgtaccg atgtgctaag cccctgctat     8160

ctaattaatg gcaggagacc atccccgttt gacgtcgtag aaggttatga gtgccaccat     8220

cggaagcctc gagcgacgta tgaagaccta gagatggaag aaatactaaa gagacgggtt     8280

cctgtctacg accctctttg tctgttcgac attgacagta aactactgcc tcccgacact     8340

tattatttgg aagaggatcg agaagacttt gagtatgcgt tgaggtgctg gggcctcggg     8400

gtttatgtag tggacgggtc cgtcacttcc cccccagata taagaataca ccacagctcc     8460

gtactgctgc tactgacacc tggagtggac tctgagctac acttgcagta tatactttgt     8520

tactctcacc aggcagaggt ggatatctac attaggggtc aacttctaga ggaggaaaat     8580

actgccacgg aagcggaagg ctttcaggag ggcggtgatg aagggacggg tgacgtggtg     8640

gcagaagatg aggacacgtt gtccacaaca gaatcaatac ccccgctaga agaggaagaa     8700

ggaggtggag agctaattac ctatgtggtt atcaggggat tgcaagaaga aagatacact     8760

agccatctca aattgaatga ctggatcagt gaaaatattt cggagccaca tagagtccaa     8820

atcatgcttg acggaacagt gagagtcaca ataaaagagg gcaaagtgaa acacctattt     8880

ggggtctaca gaatagagaa ctccctggaa gcaatgttca aagagaccat agctgacctc     8940

cccacagcca cccaaccgcc cagagggccg atctacacgg ccaaagaatt ggcccagggg     9000

aatattgccc cagtccaacc tgcagcaaat tattatggaa tgatagaggg gagaggggac     9060

ccgatgacag cgttcgaagc cttatcggtc ctgcggtcac aaaaagtctt agccaaggaa     9120

gtgaaaataa gtactcgcaa ggcacaggct tttctaaata aagtcaggag aactgctgag     9180

atcagggcct cggaattggc attaaaacgc ttaccggtac tcggaaaaat aaatgggaga     9240

aaattgatta gagaggaaac taatatcccc aaccaaaggt tggcatcgat aatgacttca     9300

ataggaatca gattagagaa actgccggtg gtcagagcaa acacctccgg ccctaagttt     9360

aggcaatcaa tcttagaaaa aatggataaa tatgaaaatg aacaagttcc agagttacat     9420

gagaagatgt gggcggcttt tctggtgacc gcccgacaag acttaagaaa tacatatgag     9480

gaagtaactt accctgaact ggagatcgga atcaaccgga agggagcacc aggttttttt     9540

gaaaaagaaa gttcaatagg agaggtactg gaaaagaagg aaaaaattga tgtcgtgatc     9600

cgagagattg aaaagggcac tcacttatat tacgaaacgg ccatgccaaa aaatgagaaa     9660

agagatgtgc ttgatgattg gttgtcagag gatttcgtca cttacaagaa accacgtgtg     9720

atacagtacc ctgaggcagt cacccgattg gccatcacca aaataatgta caagtgggta     9780

aagcagaaac ctgtagtgat ccctggctat gaggggaaaa ccccgatttt tgaaatattt     9840

gaaaaagtta gtgcagattg ggctcagttt aaaaacccag tagcagtcag cttcgatacc     9900

agggcctggg atactcaagt aacgagagag gacctcaaac tggtagggcg gatacagaaa     9960

tattactaca aaaagaaata ttggaaattc attgacaact tgactaccat gatggaggaa    10020

gtgcccgtaa tcactgtaga aggagacatg tttctcaggg tcggacaacg cgggtctgga    10080

cagcccgaca cctcagcagg taattccata ttaaacgtgc taacaatgct agtagctttc    10140

tccgaatcta caaacttgcc catagcagct gcctggaggg cctgtcgtat ccacgtctgt    10200

ggagatgacg gctttctaat cacagaatca gaattaggga ggaaattcgc tgaaaaaggt    10260

gtccccttgc tagcttcatt cggcaaaccc caaaaaatca ctgagggggc aagcttaaag    10320

ataactagca actttgatgg aatagagttt tgcagccact cccccatcag agtccaaaca    10380

ccaaacataa ggtggatgcc ggcgaggccc acagcaacaa ttctagggaa aatgagtacc    10440

aggctgggtg agggtgccac cagatcggga gaagagtatg aaaagcaggt ggcattcgca    10500

tacttactga tgtacccctg gaatccactg attaggagaa ttggcctcct attgctatca    10560

actactgacc ccatggggaa agaggaaacc ccgtgttctg acgagggggt gaaatatgtc    10620

ggggatccta ttgccgcata cagggatgta tgggggcaca aattagagga tgtagggcat    10680

gtcgatcagt cgcagttatc ccggatgaac tatagcatga cttacttagg gatctggaaa    10740

ccaaagacga gccagcgact agtcgaacag tgctgtcggc tggccgagaa aaacaattgt    10800

gtggcacgtg cagattctct aattaagaaa aaggtcaaga tcacctatga cccggggata    10860

ggagcggctc aagttattcg taggtgggaa gagctggagt ggaccagaag gaaacccgaa    10920

ttcaccaaag taactgcgga agatgacctc ttcctagtcc tttttaagag actgtcaaag    10980

tacatttttc agaaaattaa gttcatgcag aagatgttca ccccttatta agtggggggc    11040

gcttatttaa atgcagccag tatctggtgg gtataagact tgtgtgaata aaatatacaa    11100

ctgaaagggg caagtggccg tataggctgg ggcgatcgcc gtaccccccc tttaccaggc    11160

gcctcaaccc catgtaccat ggggttgttg taaatacttg aatgaatgga gtaatacggg    11220

taatggactt acaagccagt attgccccat ttgctttata gtggtgacga gatatc        11276


<210>  2
<211>  3635
<212>  PRT
<213>  Porcine pestivirus 1 strain 000515

<400>  2

Met Glu Lys Gln Ile Ala Tyr Tyr Leu Lys Lys Glu Lys Gln Arg Asn 
1               5                   10                  15      


Gly Trp Thr Glu Leu Val Val Gly Glu Ser Tyr Thr Lys Ile Thr Thr 
            20                  25                  30          


Leu Ser Gly Lys Thr Tyr Arg Gly Thr Trp Glu Met Glu Lys Arg Ser 
        35                  40                  45              


Asn Pro Tyr Gly Thr Tyr Leu Pro Arg Pro Ser Pro Gln Gln Leu Thr 
    50                  55                  60                  


Ala Ile His Pro His Pro Val Val Asn Cys Lys Val Met Glu Tyr Lys 
65                  70                  75                  80  


Glu Lys Asp Pro Asn Tyr Gly Asp Cys Pro Asn Thr Asn Gly Val Phe 
                85                  90                  95      


Ile Asp Glu Lys Gly Arg Arg Leu Ser Ser Pro Pro Leu Gly Ile Trp 
            100                 105                 110         


Lys Ile Arg Leu Asp Tyr Gly Asp Leu Val Asn Ile Asp Arg Pro Ile 
        115                 120                 125             


Pro Ala Ser Gly Lys Asn Ser Tyr Arg Val Glu Thr Cys Ser Gly Glu 
    130                 135                 140                 


Leu Ala Thr Val Thr Leu Thr His Asp Arg Val Leu Val Glu Asp Tyr 
145                 150                 155                 160 


Arg Gly Leu Tyr Gln Trp Lys Pro Asn Cys Glu Gly Met Val Leu Tyr 
                165                 170                 175     


Val Lys Thr Cys Ser Asp Trp Ala Asp Gln Val Glu Lys Gln Glu Lys 
            180                 185                 190         


Glu Ser Pro Pro Lys Pro Gln Arg Pro Pro Arg Arg Asp Pro Arg Lys 
        195                 200                 205             


Gly Leu Gln Pro Gln Val Pro Lys Glu Thr Glu Val Thr Glu Lys Lys 
    210                 215                 220                 


Arg Gln Pro Ser Val Thr Leu Val Ser Gly Gly Gln Lys Ala Gln Val 
225                 230                 235                 240 


Ile Tyr Lys Gly Lys Thr Lys Asn Lys Lys Thr Pro Asp Gly Val Tyr 
                245                 250                 255     


Lys Tyr Pro Gly Ala Arg Glu Gly Asp Val Val Lys Val Arg Lys Met 
            260                 265                 270         


Leu Lys Asn Trp His Ile Ala Leu Val Met Tyr Leu Ile Tyr Ile Ile 
        275                 280                 285             


Thr Pro Ser Phe Ala Lys Val Gln Trp Phe Leu Lys Asp Glu Asn Ser 
    290                 295                 300                 


Ser Gly Ile Asn Gln Val Leu Trp Arg Arg Gln Ile Asn Arg Ser Leu 
305                 310                 315                 320 


His Gly Glu Trp Pro Asn Gln Ile Cys His Gly Met Pro Asn Glu Thr 
                325                 330                 335     


Ile Thr Asp Glu Glu Leu Arg Ser Leu Gly Met Ile Asp Thr Ser Pro 
            340                 345                 350         


Arg Thr Asn Tyr Thr Cys Cys Gln Leu Gln Tyr His Glu Trp Lys Lys 
        355                 360                 365             


His Gly Trp Cys Asn Tyr Pro Gln Lys Gln Ala Trp Ile Arg Arg Ile 
    370                 375                 380                 


Ala Thr Leu Gln Ala Asn Leu Thr Gly Ala Tyr Lys Gly Pro Glu Cys 
385                 390                 395                 400 


Ala Val Ile Cys Arg Phe Asn Gly Thr Tyr Asn Ile Val Arg Gln Ala 
                405                 410                 415     


Arg Asp Glu Val Ser Pro Leu Thr Gly Cys Lys Glu Gly His Pro Phe 
            420                 425                 430         


Leu Phe Ser Glu Glu Arg Ser Asp Thr Ser Cys Leu Arg Pro Pro Ser 
        435                 440                 445             


Thr Ser Trp Val Arg Pro Val Lys Met Asp Glu Ala Ser Met Ala Asp 
    450                 455                 460                 


Ser Phe Ala His Gly Val Asp Lys Ala Ile Ile Leu Ile Arg Lys Gly 
465                 470                 475                 480 


Ala Ser Gly Ile Ile Asn Phe Leu Asp Thr Ile Gly Arg Trp Leu Pro 
                485                 490                 495     


Val Thr Glu Ala Ala Ile Val Pro Tyr Cys Glu Thr Tyr Thr Val Thr 
            500                 505                 510         


Gly Met Tyr Val His Val Lys Asn Cys Leu Pro Arg Gly Leu Pro Lys 
        515                 520                 525             


His Ser Lys Ile Ile Ser Pro Thr Met Ile Tyr Leu Gly Glu Gly Asp 
    530                 535                 540                 


Pro Ala His Asn Ile Gln His Leu Phe Gly Ser Gly Ile Ala Lys Trp 
545                 550                 555                 560 


Val Leu Val Leu Leu Gly Ile Leu Gly Glu Trp Tyr Gly Glu Leu Ala 
                565                 570                 575     


Ser Thr Ile Tyr Leu Leu Leu Glu Tyr Gly Ser Glu Trp Leu Glu His 
            580                 585                 590         


Glu Ser Leu Val Thr Glu Gly Leu Phe Pro Gly Ile Asn Ile Thr Ile 
        595                 600                 605             


Asp Leu Pro Ala Ser His Thr Val Pro Gly Trp Val Trp Val Ala Gly 
    610                 615                 620                 


Gln Trp Val Cys Val Lys Pro Asp Trp Trp Pro Thr Gln Val Trp Ile 
625                 630                 635                 640 


Glu Thr Val Val Ala Glu Ala Trp His Ile Leu Lys Ile Leu Ala Ser 
                645                 650                 655     


Ala Leu Val Asn Ile Val Thr Ala Phe Val Asn Leu Glu Leu Val Tyr 
            660                 665                 670         


Leu Val Ile Ile Leu Val Lys Ile Ser Lys Gly Asn Leu Ile Gly Ala 
        675                 680                 685             


Ile Leu Trp Cys Leu Leu Leu Ser Gly Ala Glu Gly Ser Cys Leu Lys 
    690                 695                 700                 


Arg Gln Asp Tyr Tyr Asn Val Gln Leu Val Val Glu Glu Lys Thr Gly 
705                 710                 715                 720 


Val Glu Lys Arg Ser Ile Met Gly Lys Trp Thr Val Ile Thr Lys Glu 
                725                 730                 735     


Gly Gln Glu Pro Arg Leu Met Glu Gln Ile Lys Met Val Ser Asn Lys 
            740                 745                 750         


Ser Val Thr Glu Ile Tyr Cys Tyr Asn Gly Leu Asn Thr Ser Ser Trp 
        755                 760                 765             


Gly Arg Gln Pro Thr Lys Gln Arg Gly Cys Ser Gln Ile Val Pro Tyr 
    770                 775                 780                 


Trp Pro Gly Asp Asn Val Leu Glu Glu Gln Tyr Tyr Ser Thr Gly Tyr 
785                 790                 795                 800 


Trp Val Asn Ala Thr Gly Ser Cys Gln Leu Arg Glu Gly Val Trp Leu 
                805                 810                 815     


Ser Arg Lys Gly Asn Val Arg Cys Gln Arg Asn Gly Thr Ser Leu Ile 
            820                 825                 830         


Leu Gln Leu Ala Ile Lys Glu Asp Asn Asp Thr Met Glu Ile Pro Cys 
        835                 840                 845             


Asp Pro Val Glu Thr Glu Ser Met Gly Pro Val Ala Gln Gly Thr Cys 
    850                 855                 860                 


Val Tyr Ser Trp Ala Val Ala Pro Arg Gly Trp Tyr Tyr Asn Arg Lys 
865                 870                 875                 880 


Asp Gly Tyr Trp Leu Gln Tyr Ile Lys Lys Asp Asp Tyr Gln Tyr Trp 
                885                 890                 895     


Thr Lys Met Pro Thr Ala Ser Ser Ala Ala Thr Met Tyr Arg His Leu 
            900                 905                 910         


Leu Pro Leu Leu Val Ala Cys Leu Met Gly Gly Arg Ile Ser Val Trp 
        915                 920                 925             


Ile Val Ala Met Leu Leu Ser Leu Gln Val Glu Ala Ser Glu Val Gly 
    930                 935                 940                 


Thr Lys Gln Leu Ala Val Thr Leu Thr Leu Trp Lys Met Asp Trp Thr 
945                 950                 955                 960 


Glu Leu Leu Phe Tyr Ile Ile Ile Met Leu Ala Val Lys Glu Asp Leu 
                965                 970                 975     


Ile Lys Lys Ile Val Thr Ala Ser Leu Val Thr Leu Lys Asn Ser Pro 
            980                 985                 990         


Val Ala Leu Ser Phe Leu Ile Val  Leu Arg Leu Val Gly  Gly Ser Glu 
        995                 1000                 1005             


Ala Leu  Pro Val Gly Leu Leu  Leu Glu Lys Met Cys  Ile Asp Gln 
    1010                 1015                 1020             


Pro Glu  Phe Gly Thr Pro Phe  Leu Ile Tyr Leu Trp  Asp Asn Trp 
    1025                 1030                 1035             


Lys Trp  Thr Val Leu Val Ser  Phe Ser Ala Leu Asn  His Glu Lys 
    1040                 1045                 1050             


Thr Ile  Arg Leu Ala Arg Lys  Leu Leu Leu Ala Thr  His Ile Thr 
    1055                 1060                 1065             


Ala Leu  Thr Leu Thr Gly Leu  Ser Asp Ser Ile Phe  Tyr Ile Met 
    1070                 1075                 1080             


Leu Ile  Met Thr Asn Leu Leu  Ile Lys Thr Phe Ile  Tyr Leu Leu 
    1085                 1090                 1095             


Gly Val  Ser Ile Asn Trp Val  Glu Lys Glu Lys Lys  Arg Leu Leu 
    1100                 1105                 1110             


Val Lys  Arg Lys Leu Ile Tyr  Lys Lys Thr Ala Ile  Cys Asn Gln 
    1115                 1120                 1125             


Asp Glu  Asn Glu Leu Glu Asn  Lys Phe Asn Lys Ile  Ser Val Asn 
    1130                 1135                 1140             


Ala Asp  Phe Thr Pro Cys Lys  Leu Glu Leu Leu Gln  Leu Leu Arg 
    1145                 1150                 1155             


Ala Phe  Leu Val Ser Leu Cys  Phe Ser Tyr Tyr Lys  Pro Leu Leu 
    1160                 1165                 1170             


Tyr Ala  Glu Thr Thr Leu Thr  Val Ile Val Ile Gly  Val Gln Glu 
    1175                 1180                 1185             


Tyr Asn  Val Ala Met Ala Arg  Gly Arg Ser Val Val  His Lys Leu 
    1190                 1195                 1200             


Leu Ala  Met Ala Tyr Tyr Val  Tyr Gly His Ile Gln  Gly Asn Met 
    1205                 1210                 1215             


Phe Gln  Leu Ala Ser Ile Gln  Cys Leu Leu Ser Ser  Pro Arg Lys 
    1220                 1225                 1230             


Ile Met  Lys His Met Ile Glu  Asn Pro Ile Leu Arg  Lys Phe Trp 
    1235                 1240                 1245             


Gln Gly  Glu Thr Glu Leu Tyr  Asn Gln Gly Val Asn  Gln Ser Lys 
    1250                 1255                 1260             


Ile Val  Asn Pro Lys Lys Ile  Gly Leu Glu Glu Leu  His Lys Gly 
    1265                 1270                 1275             


Met Cys  Gly Leu Pro Thr Val  Val Gln Asn Leu Val  Ile Tyr Ala 
    1280                 1285                 1290             


Lys Lys  Asn Asp Ser Leu Ile  Leu Gly Glu Leu Gly  Tyr Pro Pro 
    1295                 1300                 1305             


Gly Asp  Leu Thr Ser Asp Gly  Trp Glu Ile Leu Gly  Pro Gly Arg 
    1310                 1315                 1320             


Ile Pro  Lys Ile Thr Asn Val  Glu Ser Ala Lys Met  Asp Leu Leu 
    1325                 1330                 1335             


Ser Lys  Leu Met Thr Phe Leu  Gly Ile Glu Ser Ser  Arg Val Pro 
    1340                 1345                 1350             


Arg Thr  Pro Ile His Ser Thr  Arg Lys Leu Leu Lys  Ile Val Arg 
    1355                 1360                 1365             


Gly Leu  Glu Thr Gly Trp Gly  Tyr Thr His Ala Gly  Gly Ile Ser 
    1370                 1375                 1380             


Ser Ala  Lys His Val Thr Gly  Glu Lys Asn Leu Met  Thr His Met 
    1385                 1390                 1395             


Glu Gly  Arg Lys Gly Lys Tyr  Ile Leu Gln Ser Gln  Glu His Gly 
    1400                 1405                 1410             


Ala Asp  Glu Val Glu Tyr Gly  Val Lys Thr Asp Gln  Arg Ala Pro 
    1415                 1420                 1425             


Asp Asn  Ala Leu Cys Tyr Cys  Phe Asn Pro Glu Ala  Thr Asn Ile 
    1430                 1435                 1440             


Lys Gly  Glu Thr Gly Ala Met  Val Phe Met Lys Lys  Ile Gly Lys 
    1445                 1450                 1455             


Lys Trp  Thr Leu Val Thr Ser  Asp Gly Asn Lys Ala  Tyr Tyr Asn 
    1460                 1465                 1470             


Val Asn  Asn Leu Lys Gly Trp  Ser Gly Leu Pro Ile  Met Leu His 
    1475                 1480                 1485             


Ser Thr  Gly Ala Ile Val Gly  Arg Ile Lys Ser Ala  Tyr Ser Asp 
    1490                 1495                 1500             


Glu Asn  Asp Leu Val Glu Glu  Leu Ile Asp Ser Arg  Thr Ile Ser 
    1505                 1510                 1515             


Lys Ser  Asn Glu Thr Asn Leu  Asn His Leu Ile Lys  Glu Leu Ala 
    1520                 1525                 1530             


Asp Met  Arg Arg Gly Glu Phe  Arg Ser Ile Thr Leu  Gly Thr Gly 
    1535                 1540                 1545             


Ala Gly  Lys Thr Thr Glu Leu  Pro Arg Gln Tyr Leu  Thr Thr Val 
    1550                 1555                 1560             


Gly Thr  His Lys Ser Val Leu  Val Leu Val Pro Leu  Lys Ala Pro 
    1565                 1570                 1575             


Ala Glu  Ser Val Cys Arg Phe  Met Arg Ser Lys Tyr  Pro Thr Ile 
    1580                 1585                 1590             


Asn Phe  Ser Leu Arg Val Gly  Glu Arg Lys Glu Gly  Asp Val Ser 
    1595                 1600                 1605             


Ser Gly  Ile Thr Tyr Ala Thr  Tyr Gly Phe Cys Cys  Gln Leu Asn 
    1610                 1615                 1620             


Leu Val  Gln Leu Lys Glu Trp  Ile Ser Arg Tyr Ser  Met Val Phe 
    1625                 1630                 1635             


Phe Asp  Glu Tyr His Thr Ala  Thr Pro Glu Gln Ile  Ala Ile Ile 
    1640                 1645                 1650             


Ser Lys  Ile His Ala Leu Lys  Val Lys Thr Arg Ile  Val Ala Met 
    1655                 1660                 1665             


Ser Ala  Thr Pro Pro Gly Thr  Val Thr Thr Glu Gly  Arg Lys Phe 
    1670                 1675                 1680             


Asp Ile  Glu Glu Val Gly Val  Ala Thr Ile Glu Lys  Gly Glu Glu 
    1685                 1690                 1695             


Pro Lys  Arg Gly Arg Val Ala  Val Ala Gly Met Gln  Val Pro Leu 
    1700                 1705                 1710             


Glu Asp  Leu Thr Gly Lys Asn  Cys Leu Val Phe Val  Ala Thr Lys 
    1715                 1720                 1725             


Glu Ala  Ala Glu Thr Glu Ala  Lys Glu Leu Arg Ala  Arg Gly Ile 
    1730                 1735                 1740             


Asn Ala  Thr Tyr Tyr Tyr Ser  Gly Ile Asp Pro Lys  Thr Leu Glu 
    1745                 1750                 1755             


His Gly  Met Thr Asn Gln Pro  Tyr Cys Ile Val Ala  Thr Asn Ala 
    1760                 1765                 1770             


Ile Glu  Ser Gly Ile Thr Cys  Pro Asp Leu Asp Val  Val Ile Asp 
    1775                 1780                 1785             


Thr Met  Gln Lys Tyr Glu Lys  Val Val Asn Phe Ser  Ala Lys Met 
    1790                 1795                 1800             


Pro Leu  Ile Val Thr Ser Leu  Val Lys Lys Lys Ile  Thr Arg Glu 
    1805                 1810                 1815             


Glu Gln  Gly Gln Arg Lys Gly  Arg Val Gly Arg Gln  Lys Lys Gly 
    1820                 1825                 1830             


Lys Tyr  Tyr Tyr Pro Ser Gly  Val Val Pro Asn Gly  Ser Lys Asp 
    1835                 1840                 1845             


Leu Ser  Tyr Leu Ile Leu Gln  Ala Gln Glu Tyr Gly  Val Leu Glu 
    1850                 1855                 1860             


Gln Val  Asn Ile Thr Glu Tyr  Phe Ile Ile Met Asn  Glu Asp Trp 
    1865                 1870                 1875             


Gly Leu  Tyr Asp Val Asp Glu  Val Glu Val Arg Ile  Leu Glu Arg 
    1880                 1885                 1890             


Met Asn  Lys Glu Ile Leu Leu  Pro Leu Gly Ile Val  Glu Lys Gln 
    1895                 1900                 1905             


Ile Leu  Glu Arg Ser Thr His  Pro Glu Lys Val Ala  Leu Leu Tyr 
    1910                 1915                 1920             


Asn Lys  Leu Val Gln Lys Ser  Pro Ile Val Tyr Pro  Arg Val Gln 
    1925                 1930                 1935             


Glu Gly  Glu Val Ser Lys Glu  Tyr Asn Thr His Asn  Leu Ala Val 
    1940                 1945                 1950             


Tyr Asp  Lys Leu Lys Asp Val  Asn Pro Gln Ala Ile  Tyr Val Leu 
    1955                 1960                 1965             


Ala Glu  Glu Glu Arg Ala Thr  Glu Met Met Gly Leu  Glu Phe Glu 
    1970                 1975                 1980             


Gln Asp  Pro Ser Asp Leu Gln  Asp Ser Val Val Gln  Leu Cys Glu 
    1985                 1990                 1995             


Asp Ile  Lys Arg Tyr Thr Lys  Leu Ser Gly Ile Thr  Glu Lys Leu 
    2000                 2005                 2010             


Leu Val  Gly Thr Met Val Gly  Tyr Ile Gly Tyr Lys  Ala Leu Thr 
    2015                 2020                 2025             


Arg Asn  His Val Pro Trp Val  Ser Lys Glu Tyr Cys  Tyr Glu Leu 
    2030                 2035                 2040             


Thr Asp  Ser Pro Asp Thr Tyr  Glu Asn Ser Phe Ala  Pro Leu Asp 
    2045                 2050                 2055             


Val Asp  Ile Gln Asn Pro Gly  Glu Ser Lys His Pro  Glu Gln Leu 
    2060                 2065                 2070             


Ala Asp  His Gln Leu Arg Gln  Leu Leu Glu Thr Gly  Arg Asp Lys 
    2075                 2080                 2085             


Ala Ile  Asp Phe Leu Lys Gly  Val Arg Glu Phe Thr  Ser Gly Ala 
    2090                 2095                 2100             


Ile Asn  Ser Pro Lys Ala Leu  Ser Ile Trp Glu Lys  Ile Tyr Gln 
    2105                 2110                 2115             


Tyr Leu  Arg Lys His Gln Gly  Glu Ile Ile Ser Ser  Ala Ala Trp 
    2120                 2125                 2130             


Gly Ser  Ala Thr Ala Leu His  Asp Ser Ile Lys Ser  Arg Leu Gly 
    2135                 2140                 2145             


Asp Glu  Val Ala Thr Ala Val  Ile Ile Leu Lys Tyr  Leu Ala Phe 
    2150                 2155                 2160             


Gly Glu  Arg Glu Leu Ser Gly  Leu Thr Arg Gln Val  Leu Ile Asp 
    2165                 2170                 2175             


Ile Ile  Val Tyr Tyr Ile Val  Asn Lys Pro Arg Phe  Glu Gly Asp 
    2180                 2185                 2190             


Asp Tyr  Ala Lys Arg Lys Gly  Arg Arg Leu Val Ile  Glu Val Leu 
    2195                 2200                 2205             


Met Gly  Ala Leu Ala Thr Tyr  Ala Val Ser Asn Phe  Trp Gly Val 
    2210                 2215                 2220             


Ser Val  Asn Lys Ile Leu Gln  Pro Ile Ser Asp Tyr  Leu Pro Tyr 
    2225                 2230                 2235             


Ala Thr  Ala Thr Leu Ala Phe  Leu Arg Pro Thr Phe  Met Glu Ser 
    2240                 2245                 2250             


Ala Val  Val Val Ala Ser Ser  Ile Tyr Arg Ala Phe  Leu Ser Ile 
    2255                 2260                 2265             


Lys His  Ala Glu Asn Arg Ser  Leu Val Thr Gln Val  Ala Ser Ala 
    2270                 2275                 2280             


Ala Leu  Glu Val Met Gly Leu  Thr Pro Val Ser Ala  Gly Leu Gly 
    2285                 2290                 2295             


Val Leu  Leu Gly Leu Gly Leu  Cys Val Leu His Met  Asn Ile Asp 
    2300                 2305                 2310             


Lys Asn  Glu Glu Lys Arg Thr  Leu Ile Leu Lys Met  Phe Val Lys 
    2315                 2320                 2325             


Asn Phe  Ile Asp Gln Ala Ala  Leu Asp Glu Leu Asp  Lys Leu Glu 
    2330                 2335                 2340             


Pro Glu  Lys Ile Ile Leu Ser  Leu Leu Glu Gly Ile  Gln Thr Cys 
    2345                 2350                 2355             


Thr Asn  Pro Ile Arg Ala Ile  Met Ile Leu Tyr Arg  Val Tyr Tyr 
    2360                 2365                 2370             


Lys Gly  Glu Ser Phe Thr Glu  Ala Leu Ser Lys Met  Ala Gly Lys 
    2375                 2380                 2385             


Ser Leu  Ile Val Met Val Ile  Val Glu Phe Leu Glu  Leu Thr Gly 
    2390                 2395                 2400             


Gln Thr  Gln Gly Gly Tyr Ile  Asp Leu Ser Ala Asn  Leu Leu Thr 
    2405                 2410                 2415             


Phe Leu  Leu Glu Lys Leu Lys  Lys Met Thr Asn Leu  Ala Ile Gly 
    2420                 2425                 2430             


Glu Ala  Arg Lys Ala Leu Leu  Pro Ile Pro Tyr Leu  Tyr Cys Glu 
    2435                 2440                 2445             


Thr Trp  Gln Ser Asp Ala Arg  Ile Lys Ala Pro Glu  Ser Tyr Asp 
    2450                 2455                 2460             


Gln Val  Ala Val Glu Cys Arg  Cys Gly Ala Ser Ala  Arg Tyr Ser 
    2465                 2470                 2475             


Phe His  His Gly Val His Glu  Val Leu Glu Glu Lys  Met Thr Lys 
    2480                 2485                 2490             


Trp Cys  Lys Asn Phe Phe Leu  Trp Gly Pro Asn Phe  Ser Asn Pro 
    2495                 2500                 2505             


Asp Pro  Lys Arg Met Thr Phe  Tyr Glu Cys Gly Gln  Ala Arg Lys 
    2510                 2515                 2520             


Cys Pro  Val Ile Ile Met Gly  Glu Asp Ile Thr Phe  Gly Lys Tyr 
    2525                 2530                 2535             


Gly Ile  Tyr Val Lys Phe Gly  His Gly Pro Asp Gly  Arg Arg Leu 
    2540                 2545                 2550             


Ile Arg  Gly Thr Thr His Ala  Thr Ile Ser Arg Glu  Glu Leu Leu 
    2555                 2560                 2565             


Glu Ile  Leu Thr Ala Pro Ser  Gln Val Ala Ile Gly  Lys Val Lys 
    2570                 2575                 2580             


Leu Thr  Asp Tyr Cys Asn Gln  Lys Gly Met Ile Asp  Arg Lys Leu 
    2585                 2590                 2595             


Ala Val  Leu Glu Gly Asp Lys  Ile His Phe Trp Lys  Ala His Arg 
    2600                 2605                 2610             


Gly Ser  Lys Ile Thr Asp Gln  Leu Thr Ile Glu Ser  Leu Thr Asp 
    2615                 2620                 2625             


Asp Leu  Gly Ser Glu Ile Arg  Asp Ile Thr Trp Glu  Leu Tyr Thr 
    2630                 2635                 2640             


Gly Gly  Thr Cys Thr Val Lys  Gly Ile Ser Leu Arg  Ser Cys Ala 
    2645                 2650                 2655             


Pro Gly  Gln Arg Asn Lys Ala  Thr Val Leu Cys Asp  Cys Thr Asp 
    2660                 2665                 2670             


Val Leu  Ser Pro Cys Tyr Leu  Ile Asn Gly Arg Arg  Pro Ser Pro 
    2675                 2680                 2685             


Phe Asp  Val Val Glu Gly Tyr  Glu Cys His His Arg  Lys Pro Arg 
    2690                 2695                 2700             


Ala Thr  Tyr Glu Asp Leu Glu  Met Glu Glu Ile Leu  Lys Arg Arg 
    2705                 2710                 2715             


Val Pro  Val Tyr Asp Pro Leu  Cys Leu Phe Asp Ile  Asp Ser Lys 
    2720                 2725                 2730             


Leu Leu  Pro Pro Asp Thr Tyr  Tyr Leu Glu Glu Asp  Arg Glu Asp 
    2735                 2740                 2745             


Phe Glu  Tyr Ala Leu Arg Cys  Trp Gly Leu Gly Val  Tyr Val Val 
    2750                 2755                 2760             


Asp Gly  Ser Val Thr Ser Pro  Pro Asp Ile Arg Ile  His His Ser 
    2765                 2770                 2775             


Ser Val  Leu Leu Leu Leu Thr  Pro Gly Val Asp Ser  Glu Leu His 
    2780                 2785                 2790             


Leu Gln  Tyr Ile Leu Cys Tyr  Ser His Gln Ala Glu  Val Asp Ile 
    2795                 2800                 2805             


Tyr Ile  Arg Gly Gln Leu Leu  Glu Glu Glu Asn Thr  Ala Thr Glu 
    2810                 2815                 2820             


Ala Glu  Gly Phe Gln Glu Gly  Gly Asp Glu Gly Thr  Gly Asp Val 
    2825                 2830                 2835             


Val Ala  Glu Asp Glu Asp Thr  Leu Ser Thr Thr Glu  Ser Ile Pro 
    2840                 2845                 2850             


Pro Leu  Glu Glu Glu Glu Gly  Gly Gly Glu Leu Ile  Thr Tyr Val 
    2855                 2860                 2865             


Val Ile  Arg Gly Leu Gln Glu  Glu Arg Tyr Thr Ser  His Leu Lys 
    2870                 2875                 2880             


Leu Asn  Asp Trp Ile Ser Glu  Asn Ile Ser Glu Pro  His Arg Val 
    2885                 2890                 2895             


Gln Ile  Met Leu Asp Gly Thr  Val Arg Val Thr Ile  Lys Glu Gly 
    2900                 2905                 2910             


Lys Val  Lys His Leu Phe Gly  Val Tyr Arg Ile Glu  Asn Ser Leu 
    2915                 2920                 2925             


Glu Ala  Met Phe Lys Glu Thr  Ile Ala Asp Leu Pro  Thr Ala Thr 
    2930                 2935                 2940             


Gln Pro  Pro Arg Gly Pro Ile  Tyr Thr Ala Lys Glu  Leu Ala Gln 
    2945                 2950                 2955             


Gly Asn  Ile Ala Pro Val Gln  Pro Ala Ala Asn Tyr  Tyr Gly Met 
    2960                 2965                 2970             


Ile Glu  Gly Arg Gly Asp Pro  Met Thr Ala Phe Glu  Ala Leu Ser 
    2975                 2980                 2985             


Val Leu  Arg Ser Gln Lys Val  Leu Ala Lys Glu Val  Lys Ile Ser 
    2990                 2995                 3000             


Thr Arg  Lys Ala Gln Ala Phe  Leu Asn Lys Val Arg  Arg Thr Ala 
    3005                 3010                 3015             


Glu Ile  Arg Ala Ser Glu Leu  Ala Leu Lys Arg Leu  Pro Val Leu 
    3020                 3025                 3030             


Gly Lys  Ile Asn Gly Arg Lys  Leu Ile Arg Glu Glu  Thr Asn Ile 
    3035                 3040                 3045             


Pro Asn  Gln Arg Leu Ala Ser  Ile Met Thr Ser Ile  Gly Ile Arg 
    3050                 3055                 3060             


Leu Glu  Lys Leu Pro Val Val  Arg Ala Asn Thr Ser  Gly Pro Lys 
    3065                 3070                 3075             


Phe Arg  Gln Ser Ile Leu Glu  Lys Met Asp Lys Tyr  Glu Asn Glu 
    3080                 3085                 3090             


Gln Val  Pro Glu Leu His Glu  Lys Met Trp Ala Ala  Phe Leu Val 
    3095                 3100                 3105             


Thr Ala  Arg Gln Asp Leu Arg  Asn Thr Tyr Glu Glu  Val Thr Tyr 
    3110                 3115                 3120             


Pro Glu  Leu Glu Ile Gly Ile  Asn Arg Lys Gly Ala  Pro Gly Phe 
    3125                 3130                 3135             


Phe Glu  Lys Glu Ser Ser Ile  Gly Glu Val Leu Glu  Lys Lys Glu 
    3140                 3145                 3150             


Lys Ile  Asp Val Val Ile Arg  Glu Ile Glu Lys Gly  Thr His Leu 
    3155                 3160                 3165             


Tyr Tyr  Glu Thr Ala Met Pro  Lys Asn Glu Lys Arg  Asp Val Leu 
    3170                 3175                 3180             


Asp Asp  Trp Leu Ser Glu Asp  Phe Val Thr Tyr Lys  Lys Pro Arg 
    3185                 3190                 3195             


Val Ile  Gln Tyr Pro Glu Ala  Val Thr Arg Leu Ala  Ile Thr Lys 
    3200                 3205                 3210             


Ile Met  Tyr Lys Trp Val Lys  Gln Lys Pro Val Val  Ile Pro Gly 
    3215                 3220                 3225             


Tyr Glu  Gly Lys Thr Pro Ile  Phe Glu Ile Phe Glu  Lys Val Ser 
    3230                 3235                 3240             


Ala Asp  Trp Ala Gln Phe Lys  Asn Pro Val Ala Val  Ser Phe Asp 
    3245                 3250                 3255             


Thr Arg  Ala Trp Asp Thr Gln  Val Thr Arg Glu Asp  Leu Lys Leu 
    3260                 3265                 3270             


Val Gly  Arg Ile Gln Lys Tyr  Tyr Tyr Lys Lys Lys  Tyr Trp Lys 
    3275                 3280                 3285             


Phe Ile  Asp Asn Leu Thr Thr  Met Met Glu Glu Val  Pro Val Ile 
    3290                 3295                 3300             


Thr Val  Glu Gly Asp Met Phe  Leu Arg Val Gly Gln  Arg Gly Ser 
    3305                 3310                 3315             


Gly Gln  Pro Asp Thr Ser Ala  Gly Asn Ser Ile Leu  Asn Val Leu 
    3320                 3325                 3330             


Thr Met  Leu Val Ala Phe Ser  Glu Ser Thr Asn Leu  Pro Ile Ala 
    3335                 3340                 3345             


Ala Ala  Trp Arg Ala Cys Arg  Ile His Val Cys Gly  Asp Asp Gly 
    3350                 3355                 3360             


Phe Leu  Ile Thr Glu Ser Glu  Leu Gly Arg Lys Phe  Ala Glu Lys 
    3365                 3370                 3375             


Gly Val  Pro Leu Leu Ala Ser  Phe Gly Lys Pro Gln  Lys Ile Thr 
    3380                 3385                 3390             


Glu Gly  Ala Ser Leu Lys Ile  Thr Ser Asn Phe Asp  Gly Ile Glu 
    3395                 3400                 3405             


Phe Cys  Ser His Ser Pro Ile  Arg Val Gln Thr Pro  Asn Ile Arg 
    3410                 3415                 3420             


Trp Met  Pro Ala Arg Pro Thr  Ala Thr Ile Leu Gly  Lys Met Ser 
    3425                 3430                 3435             


Thr Arg  Leu Gly Glu Gly Ala  Thr Arg Ser Gly Glu  Glu Tyr Glu 
    3440                 3445                 3450             


Lys Gln  Val Ala Phe Ala Tyr  Leu Leu Met Tyr Pro  Trp Asn Pro 
    3455                 3460                 3465             


Leu Ile  Arg Arg Ile Gly Leu  Leu Leu Leu Ser Thr  Thr Asp Pro 
    3470                 3475                 3480             


Met Gly  Lys Glu Glu Thr Pro  Cys Ser Asp Glu Gly  Val Lys Tyr 
    3485                 3490                 3495             


Val Gly  Asp Pro Ile Ala Ala  Tyr Arg Asp Val Trp  Gly His Lys 
    3500                 3505                 3510             


Leu Glu  Asp Val Gly His Val  Asp Gln Ser Gln Leu  Ser Arg Met 
    3515                 3520                 3525             


Asn Tyr  Ser Met Thr Tyr Leu  Gly Ile Trp Lys Pro  Lys Thr Ser 
    3530                 3535                 3540             


Gln Arg  Leu Val Glu Gln Cys  Cys Arg Leu Ala Glu  Lys Asn Asn 
    3545                 3550                 3555             


Cys Val  Ala Arg Ala Asp Ser  Leu Ile Lys Lys Lys  Val Lys Ile 
    3560                 3565                 3570             


Thr Tyr  Asp Pro Gly Ile Gly  Ala Ala Gln Val Ile  Arg Arg Trp 
    3575                 3580                 3585             


Glu Glu  Leu Glu Trp Thr Arg  Arg Lys Pro Glu Phe  Thr Lys Val 
    3590                 3595                 3600             


Thr Ala  Glu Asp Asp Leu Phe  Leu Val Leu Phe Lys  Arg Leu Ser 
    3605                 3610                 3615             


Lys Tyr  Ile Phe Gln Lys Ile  Lys Phe Met Gln Lys  Met Phe Thr 
    3620                 3625                 3630             


Pro Tyr  
    3635 


<210>  3
<211>  624
<212>  DNA
<213>  Porcine pestivirus 1 strain 000515


<220>
<221>  Erns gene
<222>  (1)..(624)

<400>  3
aaggtccagt ggtttttaaa ggatgaaaat tcgtcaggaa ttaaccaggt attatggaga       60

agacagatca acagatccct acatggggag tggcctaacc agatttgcca tggcatgcca      120

aatgaaacta tcactgacga ggaattacgc agtttaggaa tgatagatac aagccctaga      180

acaaactata cttgctgtca gttgcaatat catgaatgga agaaacatgg ttggtgcaat      240

tacccacaaa aacaggcttg gatcaggaga atagcgaccc tgcaagccaa cctcaccgga      300

gcttataagg gacctgagtg tgctgtcatc tgtcgattta acggcaccta taacattgtg      360

agacaggcca gagacgaggt gagtccactg acagggtgta aggaagggca cccttttcta      420

ttttctgagg aaaggtccga cacctcgtgc ttgaggccgc cctccactag ttgggtgaga      480

ccagtgaaaa tggatgaggc atcgatggct gacagcttcg cccacggggt cgataaggcc      540

ataatattaa tcagaaaagg ggcatcggga attatcaatt tcctagacac tattgggaga      600

tggttaccgg tgactgaagc agct                                             624


<210>  4
<211>  208
<212>  PRT
<213>  Porcine pestivirus 1 strain 000515


<220>
<221>  MISC_FEATURE
<222>  (1)..(208)
<223>  Erns protein

<400>  4

Lys Val Gln Trp Phe Leu Lys Asp Glu Asn Ser Ser Gly Ile Asn Gln 
1               5                   10                  15      


Val Leu Trp Arg Arg Gln Ile Asn Arg Ser Leu His Gly Glu Trp Pro 
            20                  25                  30          


Asn Gln Ile Cys His Gly Met Pro Asn Glu Thr Ile Thr Asp Glu Glu 
        35                  40                  45              


Leu Arg Ser Leu Gly Met Ile Asp Thr Ser Pro Arg Thr Asn Tyr Thr 
    50                  55                  60                  


Cys Cys Gln Leu Gln Tyr His Glu Trp Lys Lys His Gly Trp Cys Asn 
65                  70                  75                  80  


Tyr Pro Gln Lys Gln Ala Trp Ile Arg Arg Ile Ala Thr Leu Gln Ala 
                85                  90                  95      


Asn Leu Thr Gly Ala Tyr Lys Gly Pro Glu Cys Ala Val Ile Cys Arg 
            100                 105                 110         


Phe Asn Gly Thr Tyr Asn Ile Val Arg Gln Ala Arg Asp Glu Val Ser 
        115                 120                 125             


Pro Leu Thr Gly Cys Lys Glu Gly His Pro Phe Leu Phe Ser Glu Glu 
    130                 135                 140                 


Arg Ser Asp Thr Ser Cys Leu Arg Pro Pro Ser Thr Ser Trp Val Arg 
145                 150                 155                 160 


Pro Val Lys Met Asp Glu Ala Ser Met Ala Asp Ser Phe Ala His Gly 
                165                 170                 175     


Val Asp Lys Ala Ile Ile Leu Ile Arg Lys Gly Ala Ser Gly Ile Ile 
            180                 185                 190         


Asn Phe Leu Asp Thr Ile Gly Arg Trp Leu Pro Val Thr Glu Ala Ala 
        195                 200                 205             


<210>  5
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  5
tttagacacg acccctcagc cc                                                22


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  6
ccacttgccc attatagacc g                                                 21


<210>  7
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  7
ttatggtgcc tgttactgtc tg                                                22


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  8
acctcgtctc tggcctgtct c                                                 21


<210>  9
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  9
agtgtgctgt catctgtcg                                                    19


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  10
cttccttaca ccctgtcagt g                                                 21


