                               SEQUENCE LISTING

<110> NEW YORK UNIVERSITY
 
<120> METHOD FOR TREATING HIGH-GRADE GLIOMAS

<130> 243735.000148

<140>
<141>

<150> 62/154,173
<151> 2015-04-29

<160> 24    

<170> PatentIn version 3.5

<210> 1
<211> 570
<212> PRT
<213> Homo sapiens

<400> 1
Met Glu Lys Leu Leu Arg Leu Cys Cys Trp Tyr Ser Trp Leu Leu Leu 
1               5                   10                  15      


Phe Tyr Tyr Asn Phe Gln Val Arg Gly Val Tyr Ser Arg Ser Gln Asp 
            20                  25                  30          


His Pro Gly Phe Gln Val Leu Ala Ser Ala Ser His Tyr Trp Pro Leu 
        35                  40                  45              


Glu Asn Val Asp Gly Ile His Glu Leu Gln Asp Thr Thr Gly Asp Ile 
    50                  55                  60                  


Val Glu Gly Lys Val Asn Lys Gly Ile Tyr Leu Lys Glu Glu Lys Gly 
65                  70                  75                  80  


Val Thr Leu Leu Tyr Tyr Gly Arg Tyr Asn Ser Ser Cys Ile Ser Lys 
                85                  90                  95      


Pro Glu Gln Cys Gly Pro Glu Gly Val Thr Phe Ser Phe Phe Trp Lys 
            100                 105                 110         


Thr Gln Gly Glu Gln Ser Arg Pro Ile Pro Ser Ala Tyr Gly Gly Gln 
        115                 120                 125             


Val Ile Ser Asn Gly Phe Lys Val Cys Ser Ser Gly Gly Arg Gly Ser 
    130                 135                 140                 


Val Glu Leu Tyr Thr Arg Asp Asn Ser Met Thr Trp Glu Ala Ser Phe 
145                 150                 155                 160 


Ser Pro Pro Gly Pro Tyr Trp Thr His Val Leu Phe Thr Trp Lys Ser 
                165                 170                 175     


Lys Glu Gly Leu Lys Val Tyr Val Asn Gly Thr Leu Ser Thr Ser Asp 
            180                 185                 190         


Pro Ser Gly Lys Val Ser Arg Asp Tyr Gly Glu Ser Asn Val Asn Leu 
        195                 200                 205             


Val Ile Gly Ser Glu Gln Asp Gln Ala Lys Cys Tyr Glu Asn Gly Ala 
    210                 215                 220                 


Phe Asp Glu Phe Ile Ile Trp Glu Arg Ala Leu Thr Pro Asp Glu Ile 
225                 230                 235                 240 


Ala Met Tyr Phe Thr Ala Ala Ile Gly Lys His Ala Leu Leu Ser Ser 
                245                 250                 255     


Thr Leu Pro Ser Leu Phe Met Thr Ser Thr Ala Ser Pro Val Met Pro 
            260                 265                 270         


Thr Asp Ala Tyr His Pro Ile Ile Thr Asn Leu Thr Glu Glu Arg Lys 
        275                 280                 285             


Thr Phe Gln Ser Pro Gly Val Ile Leu Ser Tyr Leu Gln Asn Val Ser 
    290                 295                 300                 


Leu Ser Leu Pro Ser Lys Ser Leu Ser Glu Gln Thr Ala Leu Asn Leu 
305                 310                 315                 320 


Thr Lys Thr Phe Leu Lys Ala Val Gly Glu Ile Leu Leu Leu Pro Gly 
                325                 330                 335     


Trp Ile Ala Leu Ser Glu Asp Ser Ala Val Val Leu Ser Leu Ile Asp 
            340                 345                 350         


Thr Ile Asp Thr Val Met Gly His Val Ser Ser Asn Leu His Gly Ser 
        355                 360                 365             


Thr Pro Gln Val Thr Val Glu Gly Ser Ser Ala Met Ala Glu Phe Ser 
    370                 375                 380                 


Val Ala Lys Ile Leu Pro Lys Thr Val Asn Ser Ser His Tyr Arg Phe 
385                 390                 395                 400 


Pro Ala His Gly Gln Ser Phe Ile Gln Ile Pro His Glu Ala Phe His 
                405                 410                 415     


Arg His Ala Trp Ser Thr Val Val Gly Leu Leu Tyr His Ser Met His 
            420                 425                 430         


Tyr Tyr Leu Asn Asn Ile Trp Pro Ala His Thr Lys Ile Ala Glu Ala 
        435                 440                 445             


Met His His Gln Asp Cys Leu Leu Phe Ala Thr Ser His Leu Ile Ser 
    450                 455                 460                 


Leu Glu Val Ser Pro Pro Pro Thr Leu Ser Gln Asn Leu Ser Gly Ser 
465                 470                 475                 480 


Pro Leu Ile Thr Val His Leu Lys His Arg Leu Thr Arg Lys Gln His 
                485                 490                 495     


Ser Glu Ala Thr Asn Ser Ser Asn Arg Val Phe Val Tyr Cys Ala Phe 
            500                 505                 510         


Leu Asp Phe Ser Ser Gly Glu Gly Val Trp Ser Asn His Gly Cys Ala 
        515                 520                 525             


Leu Thr Arg Gly Asn Leu Thr Tyr Ser Val Cys Arg Cys Thr His Leu 
    530                 535                 540                 


Thr Asn Phe Ala Ile Leu Met Gln Val Val Pro Leu Glu Leu Ala Arg 
545                 550                 555                 560 


Gly His Gln Val Ala Leu Ser Ser Ile Ser 
                565                 570 


<210> 2
<211> 256
<212> PRT
<213> Homo sapiens

<400> 2
Met Glu Lys Gly Thr Glu Leu Leu Val Ser Pro Ser Gln Ser Gly Pro 
1               5                   10                  15      


Gly Gly Asp Gln Pro Leu Leu Val Lys His Arg Glu Asp Ser Ala Val 
            20                  25                  30          


Val Leu Ser Leu Ile Asp Thr Ile Asp Thr Val Met Gly His Val Ser 
        35                  40                  45              


Ser Asn Leu His Gly Ser Thr Pro Gln Val Thr Val Glu Gly Ser Ser 
    50                  55                  60                  


Ala Met Ala Glu Phe Ser Val Ala Lys Ile Leu Pro Lys Thr Val Asn 
65                  70                  75                  80  


Ser Ser His Tyr Arg Phe Pro Ala His Gly Gln Ser Phe Ile Gln Ile 
                85                  90                  95      


Pro His Glu Ala Phe His Arg His Ala Trp Ser Thr Val Val Gly Leu 
            100                 105                 110         


Leu Tyr His Ser Met His Tyr Tyr Leu Asn Asn Ile Trp Pro Ala His 
        115                 120                 125             


Thr Lys Ile Ala Glu Ala Met His His Gln Asp Cys Leu Leu Phe Ala 
    130                 135                 140                 


Thr Ser His Leu Ile Ser Leu Glu Val Ser Pro Pro Pro Thr Leu Ser 
145                 150                 155                 160 


Gln Asn Leu Ser Gly Ser Pro Leu Ile Thr Val His Leu Lys His Arg 
                165                 170                 175     


Leu Thr Arg Lys Gln His Ser Glu Ala Thr Asn Ser Ser Asn Arg Val 
            180                 185                 190         


Phe Val Tyr Cys Ala Phe Leu Asp Phe Ser Ser Gly Glu Gly Val Trp 
        195                 200                 205             


Ser Asn His Gly Cys Ala Leu Thr Arg Gly Asn Leu Thr Tyr Ser Val 
    210                 215                 220                 


Cys Arg Cys Thr His Leu Thr Asn Phe Ala Ile Leu Met Gln Val Val 
225                 230                 235                 240 


Pro Leu Glu Leu Ala Arg Gly His Gln Val Ala Leu Ser Ser Ile Ser 
                245                 250                 255     


<210> 3
<211> 89
<212> PRT
<213> Homo sapiens

<400> 3
Met His Arg Val Cys Phe Leu Ser Phe Gln Thr Arg Lys Gln His Ser 
1               5                   10                  15      


Glu Ala Thr Asn Ser Ser Asn Arg Val Phe Val Tyr Cys Ala Phe Leu 
            20                  25                  30          


Asp Phe Ser Ser Gly Glu Gly Val Trp Ser Asn His Gly Cys Ala Leu 
        35                  40                  45              


Thr Arg Gly Asn Leu Thr Tyr Ser Val Cys Arg Cys Thr His Leu Thr 
    50                  55                  60                  


Asn Phe Ala Ile Leu Met Gln Val Val Pro Leu Glu Leu Ala Arg Gly 
65                  70                  75                  80  


His Gln Val Ala Leu Ser Ser Ile Ser 
                85                  


<210> 4
<211> 602
<212> PRT
<213> Homo sapiens

<400> 4
Met Glu Lys Leu Leu Arg Leu Cys Cys Trp Tyr Ser Trp Leu Leu Leu 
1               5                   10                  15      


Phe Tyr Tyr Asn Phe Gln Val Arg Gly Val Tyr Ser Arg Ser Gln Asp 
            20                  25                  30          


His Pro Gly Phe Gln Val Leu Ala Ser Ala Ser His Tyr Trp Pro Leu 
        35                  40                  45              


Glu Asn Val Asp Gly Ile His Glu Leu Gln Asp Thr Thr Gly Ala Ser 
    50                  55                  60                  


Arg Thr His Lys Leu Thr Val Leu Pro Ser Arg Asn Ala Thr Phe Val 
65                  70                  75                  80  


Tyr Ser Asn Asp Ser Ala Tyr Ser Asn Leu Ser Ala Thr Val Asp Ile 
                85                  90                  95      


Val Glu Gly Lys Val Asn Lys Gly Ile Tyr Leu Lys Glu Glu Lys Gly 
            100                 105                 110         


Val Thr Leu Leu Tyr Tyr Gly Arg Tyr Asn Ser Ser Cys Ile Ser Lys 
        115                 120                 125             


Pro Glu Gln Cys Gly Pro Glu Gly Val Thr Phe Ser Phe Phe Trp Lys 
    130                 135                 140                 


Thr Gln Gly Glu Gln Ser Arg Pro Ile Pro Ser Ala Tyr Gly Gly Gln 
145                 150                 155                 160 


Val Ile Ser Asn Gly Phe Lys Val Cys Ser Ser Gly Gly Arg Gly Ser 
                165                 170                 175     


Val Glu Leu Tyr Thr Arg Asp Asn Ser Met Thr Trp Glu Ala Ser Phe 
            180                 185                 190         


Ser Pro Pro Gly Pro Tyr Trp Thr His Val Leu Phe Thr Trp Lys Ser 
        195                 200                 205             


Lys Glu Gly Leu Lys Val Tyr Val Asn Gly Thr Leu Ser Thr Ser Asp 
    210                 215                 220                 


Pro Ser Gly Lys Val Ser Arg Asp Tyr Gly Glu Ser Asn Val Asn Leu 
225                 230                 235                 240 


Val Ile Gly Ser Glu Gln Asp Gln Ala Lys Cys Tyr Glu Asn Gly Ala 
                245                 250                 255     


Phe Asp Glu Phe Ile Ile Trp Glu Arg Ala Leu Thr Pro Asp Glu Ile 
            260                 265                 270         


Ala Met Tyr Phe Thr Ala Ala Ile Gly Lys His Ala Leu Leu Ser Ser 
        275                 280                 285             


Thr Leu Pro Ser Leu Phe Met Thr Ser Thr Ala Ser Pro Val Met Pro 
    290                 295                 300                 


Thr Asp Ala Tyr His Pro Ile Ile Thr Asn Leu Thr Glu Glu Arg Lys 
305                 310                 315                 320 


Thr Phe Gln Ser Pro Gly Val Ile Leu Ser Tyr Leu Gln Asn Val Ser 
                325                 330                 335     


Leu Ser Leu Pro Ser Lys Ser Leu Ser Glu Gln Thr Ala Leu Asn Leu 
            340                 345                 350         


Thr Lys Thr Phe Leu Lys Ala Val Gly Glu Ile Leu Leu Leu Pro Gly 
        355                 360                 365             


Trp Ile Ala Leu Ser Glu Asp Ser Ala Val Val Leu Ser Leu Ile Asp 
    370                 375                 380                 


Thr Ile Asp Thr Val Met Gly His Val Ser Ser Asn Leu His Gly Ser 
385                 390                 395                 400 


Thr Pro Gln Val Thr Val Glu Gly Ser Ser Ala Met Ala Glu Phe Ser 
                405                 410                 415     


Val Ala Lys Ile Leu Pro Lys Thr Val Asn Ser Ser His Tyr Arg Phe 
            420                 425                 430         


Pro Ala His Gly Gln Ser Phe Ile Gln Ile Pro His Glu Ala Phe His 
        435                 440                 445             


Arg His Ala Trp Ser Thr Val Val Gly Leu Leu Tyr His Ser Met His 
    450                 455                 460                 


Tyr Tyr Leu Asn Asn Ile Trp Pro Ala His Thr Lys Ile Ala Glu Ala 
465                 470                 475                 480 


Met His His Gln Asp Cys Leu Leu Phe Ala Thr Ser His Leu Ile Ser 
                485                 490                 495     


Leu Glu Val Ser Pro Pro Pro Thr Leu Ser Gln Asn Leu Ser Gly Ser 
            500                 505                 510         


Pro Leu Ile Thr Val His Leu Lys His Arg Leu Thr Arg Lys Gln His 
        515                 520                 525             


Ser Glu Ala Thr Asn Ser Ser Asn Arg Val Phe Val Tyr Cys Ala Phe 
    530                 535                 540                 


Leu Asp Phe Ser Ser Gly Glu Gly Val Trp Ser Asn His Gly Cys Ala 
545                 550                 555                 560 


Leu Thr Arg Gly Asn Leu Thr Tyr Ser Val Cys Arg Cys Thr His Leu 
                565                 570                 575     


Thr Asn Phe Ala Ile Leu Met Gln Val Val Pro Leu Glu Leu Ala Arg 
            580                 585                 590         


Gly His Gln Val Ala Leu Ser Ser Ile Ser 
        595                 600         


<210> 5
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
gggatcatag atgtgaatta a                                                 21


<210> 6
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
ggagtcacgc ttctctatta c                                                 21


<210> 7
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
cctgcaggga ctgttcatat t                                                 21


<210> 8
<211> 130
<212> PRT
<213> Homo sapiens

<400> 8
Val Asn Lys Gly Ile Tyr Leu Lys Glu Glu Lys Gly Val Thr Leu Leu 
1               5                   10                  15      


Tyr Tyr Gly Arg Tyr Asn Ser Ser Cys Ile Ser Lys Pro Glu Gln Cys 
            20                  25                  30          


Gly Pro Glu Gly Val Thr Phe Ser Phe Phe Trp Lys Thr Gln Gly Glu 
        35                  40                  45              


Gln Ser Arg Pro Ile Pro Ser Ala Tyr Gly Gly Gln Val Ile Ser Asn 
    50                  55                  60                  


Gly Phe Lys Val Cys Ser Ser Gly Gly Arg Gly Ser Val Glu Leu Tyr 
65                  70                  75                  80  


Thr Arg Asp Asn Ser Met Thr Trp Glu Ala Ser Phe Ser Pro Pro Gly 
                85                  90                  95      


Pro Tyr Trp Thr His Val Leu Phe Thr Trp Lys Ser Lys Glu Gly Leu 
            100                 105                 110         


Lys Val Tyr Val Asn Gly Thr Leu Val Ile Gly Ser Glu Gln Asp Gln 
        115                 120                 125             


Ala Lys 
    130 


<210> 9
<211> 110
<212> PRT
<213> Homo sapiens

<400> 9
Ala Val Val Leu Ser Leu Ile Asp Thr Ile Asp Thr Val Met Gly His 
1               5                   10                  15      


Val Ser Ser Asn Leu His Gly Ser Thr Pro Gln Val Thr Val Glu Gly 
            20                  25                  30          


Ser Ser Ala Met Ala Glu Phe Ser Val Ala Lys Ile Leu Pro Lys Thr 
        35                  40                  45              


Val Asn Ser Ser His Tyr Arg Phe Pro Ala His Gly Gln Ser Phe Ile 
    50                  55                  60                  


Gln Ile Pro His Glu Ala Phe His Arg His Ala Trp Ser Thr Val Val 
65                  70                  75                  80  


Gly Leu Leu Tyr His Ser Met His Tyr Tyr Leu Asn Asn Ile Trp Pro 
                85                  90                  95      


Ala His Thr Lys Ile Ala Glu Ala Met His His Gln Asp Cys 
            100                 105                 110 


<210> 10
<211> 15
<212> PRT
<213> Homo sapiens

<400> 10
Thr Arg Lys Gln His Ser Glu Ala Thr Asn Ser Ser Asn Arg Cys 
1               5                   10                  15  


<210> 11
<211> 12
<212> PRT
<213> Homo sapiens

<400> 11
Cys Ser Ser Gly Glu Gly Val Trp Ser Asn His Gly 
1               5                   10          


<210> 12
<211> 15
<212> PRT
<213> Homo sapiens

<400> 12
Cys Ser Ser Ala Arg Thr Ser Asn Ala Lys Pro Phe His Ser Asp 
1               5                   10                  15  


<210> 13
<211> 16
<212> PRT
<213> Homo sapiens

<400> 13
Leu Met Asn Gly Thr Arg Pro Gly Met Ala Ser Thr Lys Leu Ser Cys 
1               5                   10                  15      


<210> 14
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
cctaaggtta agtcgccctc g                                                 21


<210> 15
<211> 874
<212> PRT
<213> Homo sapiens

<400> 15
Met Glu Lys Leu Leu Arg Leu Cys Cys Trp Tyr Ser Trp Leu Leu Leu 
1               5                   10                  15      


Phe Tyr Tyr Asn Phe Gln Val Arg Gly Val Tyr Ser Arg Ser Gln Asp 
            20                  25                  30          


His Pro Gly Phe Gln Val Leu Ala Ser Ala Ser His Tyr Trp Pro Leu 
        35                  40                  45              


Glu Asn Val Asp Gly Ile His Glu Leu Gln Asp Thr Thr Gly Asp Ile 
    50                  55                  60                  


Val Glu Gly Lys Val Asn Lys Gly Ile Tyr Leu Lys Glu Glu Lys Gly 
65                  70                  75                  80  


Val Thr Leu Leu Tyr Tyr Gly Arg Tyr Asn Ser Ser Cys Ile Ser Lys 
                85                  90                  95      


Pro Glu Gln Cys Gly Pro Glu Gly Val Thr Phe Ser Phe Phe Trp Lys 
            100                 105                 110         


Thr Gln Gly Glu Gln Ser Arg Pro Ile Pro Ser Ala Tyr Gly Gly Gln 
        115                 120                 125             


Val Ile Ser Asn Gly Phe Lys Val Cys Ser Ser Gly Gly Arg Gly Ser 
    130                 135                 140                 


Val Glu Leu Tyr Thr Arg Asp Asn Ser Met Thr Trp Glu Ala Ser Phe 
145                 150                 155                 160 


Ser Pro Pro Gly Pro Tyr Trp Thr His Val Leu Phe Thr Trp Lys Ser 
                165                 170                 175     


Lys Glu Gly Leu Lys Val Tyr Val Asn Gly Thr Leu Ser Thr Ser Asp 
            180                 185                 190         


Pro Ser Gly Lys Val Ser Arg Asp Tyr Gly Glu Ser Asn Val Asn Leu 
        195                 200                 205             


Val Ile Gly Ser Glu Gln Asp Gln Ala Lys Cys Tyr Glu Asn Gly Ala 
    210                 215                 220                 


Phe Asp Glu Phe Ile Ile Trp Glu Arg Ala Leu Thr Pro Asp Glu Ile 
225                 230                 235                 240 


Ala Met Tyr Phe Thr Ala Ala Ile Gly Lys His Ala Leu Leu Ser Ser 
                245                 250                 255     


Thr Leu Pro Ser Leu Phe Met Thr Ser Thr Ala Ser Pro Val Met Pro 
            260                 265                 270         


Thr Asp Ala Tyr His Pro Ile Ile Thr Asn Leu Thr Glu Glu Arg Lys 
        275                 280                 285             


Thr Phe Gln Ser Pro Gly Val Ile Leu Ser Tyr Leu Gln Asn Val Ser 
    290                 295                 300                 


Leu Ser Leu Pro Ser Lys Ser Leu Ser Glu Gln Thr Ala Leu Asn Leu 
305                 310                 315                 320 


Thr Lys Thr Phe Leu Lys Ala Val Gly Glu Ile Leu Leu Leu Pro Gly 
                325                 330                 335     


Trp Ile Ala Leu Ser Glu Asp Ser Ala Val Val Leu Ser Leu Ile Asp 
            340                 345                 350         


Thr Ile Asp Thr Val Met Gly His Val Ser Ser Asn Leu His Gly Ser 
        355                 360                 365             


Thr Pro Gln Val Thr Val Glu Gly Ser Ser Ala Met Ala Glu Phe Ser 
    370                 375                 380                 


Val Ala Lys Ile Leu Pro Lys Thr Val Asn Ser Ser His Tyr Arg Phe 
385                 390                 395                 400 


Pro Ala His Gly Gln Ser Phe Ile Gln Ile Pro His Glu Ala Phe His 
                405                 410                 415     


Arg His Ala Trp Ser Thr Val Val Gly Leu Leu Tyr His Ser Met His 
            420                 425                 430         


Tyr Tyr Leu Asn Asn Ile Trp Pro Ala His Thr Lys Ile Ala Glu Ala 
        435                 440                 445             


Met His His Gln Asp Cys Leu Leu Phe Ala Thr Ser His Leu Ile Ser 
    450                 455                 460                 


Leu Glu Val Ser Pro Pro Pro Thr Leu Ser Gln Asn Leu Ser Gly Ser 
465                 470                 475                 480 


Pro Leu Ile Thr Val His Leu Lys His Arg Leu Thr Arg Lys Gln His 
                485                 490                 495     


Ser Glu Ala Thr Asn Ser Ser Asn Arg Val Phe Val Tyr Cys Ala Phe 
            500                 505                 510         


Leu Asp Phe Ser Ser Gly Glu Gly Val Trp Ser Asn His Gly Cys Ala 
        515                 520                 525             


Leu Thr Arg Gly Asn Leu Thr Tyr Ser Val Cys Arg Cys Thr His Leu 
    530                 535                 540                 


Thr Asn Phe Ala Ile Leu Met Gln Val Val Pro Leu Glu Leu Ala Arg 
545                 550                 555                 560 


Gly His Gln Val Ala Leu Ser Ser Ile Ser Tyr Val Gly Cys Ser Leu 
                565                 570                 575     


Ser Val Leu Cys Leu Val Ala Thr Leu Val Thr Phe Ala Val Leu Ser 
            580                 585                 590         


Ser Val Ser Thr Ile Arg Asn Gln Arg Tyr His Ile His Ala Asn Leu 
        595                 600                 605             


Ser Phe Ala Val Leu Val Ala Gln Val Leu Leu Leu Ile Ser Phe Arg 
    610                 615                 620                 


Leu Glu Pro Gly Thr Thr Pro Cys Gln Val Met Ala Val Leu Leu His 
625                 630                 635                 640 


Tyr Phe Phe Leu Ser Ala Phe Ala Trp Met Leu Val Glu Gly Leu His 
                645                 650                 655     


Leu Tyr Ser Met Val Ile Lys Val Phe Gly Ser Glu Asp Ser Lys His 
            660                 665                 670         


Arg Tyr Tyr Tyr Gly Met Gly Trp Gly Phe Pro Leu Leu Ile Cys Ile 
        675                 680                 685             


Ile Ser Leu Ser Phe Ala Met Asp Ser Tyr Gly Thr Ser Asn Asn Cys 
    690                 695                 700                 


Trp Leu Ser Leu Ala Ser Gly Ala Ile Trp Ala Phe Val Ala Pro Ala 
705                 710                 715                 720 


Leu Phe Val Ile Val Val Asn Ile Gly Ile Leu Ile Ala Val Thr Arg 
                725                 730                 735     


Val Ile Ser Gln Ile Ser Ala Asp Asn Tyr Lys Ile His Gly Asp Pro 
            740                 745                 750         


Ser Ala Phe Lys Leu Thr Ala Lys Ala Val Ala Val Leu Leu Pro Ile 
        755                 760                 765             


Leu Gly Thr Ser Trp Val Phe Gly Val Leu Ala Val Asn Gly Cys Ala 
    770                 775                 780                 


Val Val Phe Gln Tyr Met Phe Ala Thr Leu Asn Ser Leu Gln Gly Leu 
785                 790                 795                 800 


Phe Ile Phe Leu Phe His Cys Leu Leu Asn Ser Glu Val Arg Ala Ala 
                805                 810                 815     


Phe Lys His Lys Thr Lys Val Trp Ser Leu Thr Ser Ser Ser Ala Arg 
            820                 825                 830         


Thr Ser Asn Ala Lys Pro Phe His Ser Asp Leu Met Asn Gly Thr Arg 
        835                 840                 845             


Pro Gly Met Ala Ser Thr Lys Leu Ser Pro Trp Asp Lys Ser Ser His 
    850                 855                 860                 


Ser Ala His Arg Val Asp Leu Ser Ala Val 
865                 870                 


<210> 16
<211> 560
<212> PRT
<213> Homo sapiens

<400> 16
Met Glu Lys Gly Thr Glu Leu Leu Val Ser Pro Ser Gln Ser Gly Pro 
1               5                   10                  15      


Gly Gly Asp Gln Pro Leu Leu Val Lys His Arg Glu Asp Ser Ala Val 
            20                  25                  30          


Val Leu Ser Leu Ile Asp Thr Ile Asp Thr Val Met Gly His Val Ser 
        35                  40                  45              


Ser Asn Leu His Gly Ser Thr Pro Gln Val Thr Val Glu Gly Ser Ser 
    50                  55                  60                  


Ala Met Ala Glu Phe Ser Val Ala Lys Ile Leu Pro Lys Thr Val Asn 
65                  70                  75                  80  


Ser Ser His Tyr Arg Phe Pro Ala His Gly Gln Ser Phe Ile Gln Ile 
                85                  90                  95      


Pro His Glu Ala Phe His Arg His Ala Trp Ser Thr Val Val Gly Leu 
            100                 105                 110         


Leu Tyr His Ser Met His Tyr Tyr Leu Asn Asn Ile Trp Pro Ala His 
        115                 120                 125             


Thr Lys Ile Ala Glu Ala Met His His Gln Asp Cys Leu Leu Phe Ala 
    130                 135                 140                 


Thr Ser His Leu Ile Ser Leu Glu Val Ser Pro Pro Pro Thr Leu Ser 
145                 150                 155                 160 


Gln Asn Leu Ser Gly Ser Pro Leu Ile Thr Val His Leu Lys His Arg 
                165                 170                 175     


Leu Thr Arg Lys Gln His Ser Glu Ala Thr Asn Ser Ser Asn Arg Val 
            180                 185                 190         


Phe Val Tyr Cys Ala Phe Leu Asp Phe Ser Ser Gly Glu Gly Val Trp 
        195                 200                 205             


Ser Asn His Gly Cys Ala Leu Thr Arg Gly Asn Leu Thr Tyr Ser Val 
    210                 215                 220                 


Cys Arg Cys Thr His Leu Thr Asn Phe Ala Ile Leu Met Gln Val Val 
225                 230                 235                 240 


Pro Leu Glu Leu Ala Arg Gly His Gln Val Ala Leu Ser Ser Ile Ser 
                245                 250                 255     


Tyr Val Gly Cys Ser Leu Ser Val Leu Cys Leu Val Ala Thr Leu Val 
            260                 265                 270         


Thr Phe Ala Val Leu Ser Ser Val Ser Thr Ile Arg Asn Gln Arg Tyr 
        275                 280                 285             


His Ile His Ala Asn Leu Ser Phe Ala Val Leu Val Ala Gln Val Leu 
    290                 295                 300                 


Leu Leu Ile Ser Phe Arg Leu Glu Pro Gly Thr Thr Pro Cys Gln Val 
305                 310                 315                 320 


Met Ala Val Leu Leu His Tyr Phe Phe Leu Ser Ala Phe Ala Trp Met 
                325                 330                 335     


Leu Val Glu Gly Leu His Leu Tyr Ser Met Val Ile Lys Val Phe Gly 
            340                 345                 350         


Ser Glu Asp Ser Lys His Arg Tyr Tyr Tyr Gly Met Gly Trp Gly Phe 
        355                 360                 365             


Pro Leu Leu Ile Cys Ile Ile Ser Leu Ser Phe Ala Met Asp Ser Tyr 
    370                 375                 380                 


Gly Thr Ser Asn Asn Cys Trp Leu Ser Leu Ala Ser Gly Ala Ile Trp 
385                 390                 395                 400 


Ala Phe Val Ala Pro Ala Leu Phe Val Ile Val Val Asn Ile Gly Ile 
                405                 410                 415     


Leu Ile Ala Val Thr Arg Val Ile Ser Gln Ile Ser Ala Asp Asn Tyr 
            420                 425                 430         


Lys Ile His Gly Asp Pro Ser Ala Phe Lys Leu Thr Ala Lys Ala Val 
        435                 440                 445             


Ala Val Leu Leu Pro Ile Leu Gly Thr Ser Trp Val Phe Gly Val Leu 
    450                 455                 460                 


Ala Val Asn Gly Cys Ala Val Val Phe Gln Tyr Met Phe Ala Thr Leu 
465                 470                 475                 480 


Asn Ser Leu Gln Gly Leu Phe Ile Phe Leu Phe His Cys Leu Leu Asn 
                485                 490                 495     


Ser Glu Val Arg Ala Ala Phe Lys His Lys Thr Lys Val Trp Ser Leu 
            500                 505                 510         


Thr Ser Ser Ser Ala Arg Thr Ser Asn Ala Lys Pro Phe His Ser Asp 
        515                 520                 525             


Leu Met Asn Gly Thr Arg Pro Gly Met Ala Ser Thr Lys Leu Ser Pro 
    530                 535                 540                 


Trp Asp Lys Ser Ser His Ser Ala His Arg Val Asp Leu Ser Ala Val 
545                 550                 555                 560 


<210> 17
<211> 393
<212> PRT
<213> Homo sapiens

<400> 17
Met His Arg Val Cys Phe Leu Ser Phe Gln Thr Arg Lys Gln His Ser 
1               5                   10                  15      


Glu Ala Thr Asn Ser Ser Asn Arg Val Phe Val Tyr Cys Ala Phe Leu 
            20                  25                  30          


Asp Phe Ser Ser Gly Glu Gly Val Trp Ser Asn His Gly Cys Ala Leu 
        35                  40                  45              


Thr Arg Gly Asn Leu Thr Tyr Ser Val Cys Arg Cys Thr His Leu Thr 
    50                  55                  60                  


Asn Phe Ala Ile Leu Met Gln Val Val Pro Leu Glu Leu Ala Arg Gly 
65                  70                  75                  80  


His Gln Val Ala Leu Ser Ser Ile Ser Tyr Val Gly Cys Ser Leu Ser 
                85                  90                  95      


Val Leu Cys Leu Val Ala Thr Leu Val Thr Phe Ala Val Leu Ser Ser 
            100                 105                 110         


Val Ser Thr Ile Arg Asn Gln Arg Tyr His Ile His Ala Asn Leu Ser 
        115                 120                 125             


Phe Ala Val Leu Val Ala Gln Val Leu Leu Leu Ile Ser Phe Arg Leu 
    130                 135                 140                 


Glu Pro Gly Thr Thr Pro Cys Gln Val Met Ala Val Leu Leu His Tyr 
145                 150                 155                 160 


Phe Phe Leu Ser Ala Phe Ala Trp Met Leu Val Glu Gly Leu His Leu 
                165                 170                 175     


Tyr Ser Met Val Ile Lys Val Phe Gly Ser Glu Asp Ser Lys His Arg 
            180                 185                 190         


Tyr Tyr Tyr Gly Met Gly Trp Gly Phe Pro Leu Leu Ile Cys Ile Ile 
        195                 200                 205             


Ser Leu Ser Phe Ala Met Asp Ser Tyr Gly Thr Ser Asn Asn Cys Trp 
    210                 215                 220                 


Leu Ser Leu Ala Ser Gly Ala Ile Trp Ala Phe Val Ala Pro Ala Leu 
225                 230                 235                 240 


Phe Val Ile Val Val Asn Ile Gly Ile Leu Ile Ala Val Thr Arg Val 
                245                 250                 255     


Ile Ser Gln Ile Ser Ala Asp Asn Tyr Lys Ile His Gly Asp Pro Ser 
            260                 265                 270         


Ala Phe Lys Leu Thr Ala Lys Ala Val Ala Val Leu Leu Pro Ile Leu 
        275                 280                 285             


Gly Thr Ser Trp Val Phe Gly Val Leu Ala Val Asn Gly Cys Ala Val 
    290                 295                 300                 


Val Phe Gln Tyr Met Phe Ala Thr Leu Asn Ser Leu Gln Gly Leu Phe 
305                 310                 315                 320 


Ile Phe Leu Phe His Cys Leu Leu Asn Ser Glu Val Arg Ala Ala Phe 
                325                 330                 335     


Lys His Lys Thr Lys Val Trp Ser Leu Thr Ser Ser Ser Ala Arg Thr 
            340                 345                 350         


Ser Asn Ala Lys Pro Phe His Ser Asp Leu Met Asn Gly Thr Arg Pro 
        355                 360                 365             


Gly Met Ala Ser Thr Lys Leu Ser Pro Trp Asp Lys Ser Ser His Ser 
    370                 375                 380                 


Ala His Arg Val Asp Leu Ser Ala Val 
385                 390             


<210> 18
<211> 906
<212> PRT
<213> Homo sapiens

<400> 18
Met Glu Lys Leu Leu Arg Leu Cys Cys Trp Tyr Ser Trp Leu Leu Leu 
1               5                   10                  15      


Phe Tyr Tyr Asn Phe Gln Val Arg Gly Val Tyr Ser Arg Ser Gln Asp 
            20                  25                  30          


His Pro Gly Phe Gln Val Leu Ala Ser Ala Ser His Tyr Trp Pro Leu 
        35                  40                  45              


Glu Asn Val Asp Gly Ile His Glu Leu Gln Asp Thr Thr Gly Ala Ser 
    50                  55                  60                  


Arg Thr His Lys Leu Thr Val Leu Pro Ser Arg Asn Ala Thr Phe Val 
65                  70                  75                  80  


Tyr Ser Asn Asp Ser Ala Tyr Ser Asn Leu Ser Ala Thr Val Asp Ile 
                85                  90                  95      


Val Glu Gly Lys Val Asn Lys Gly Ile Tyr Leu Lys Glu Glu Lys Gly 
            100                 105                 110         


Val Thr Leu Leu Tyr Tyr Gly Arg Tyr Asn Ser Ser Cys Ile Ser Lys 
        115                 120                 125             


Pro Glu Gln Cys Gly Pro Glu Gly Val Thr Phe Ser Phe Phe Trp Lys 
    130                 135                 140                 


Thr Gln Gly Glu Gln Ser Arg Pro Ile Pro Ser Ala Tyr Gly Gly Gln 
145                 150                 155                 160 


Val Ile Ser Asn Gly Phe Lys Val Cys Ser Ser Gly Gly Arg Gly Ser 
                165                 170                 175     


Val Glu Leu Tyr Thr Arg Asp Asn Ser Met Thr Trp Glu Ala Ser Phe 
            180                 185                 190         


Ser Pro Pro Gly Pro Tyr Trp Thr His Val Leu Phe Thr Trp Lys Ser 
        195                 200                 205             


Lys Glu Gly Leu Lys Val Tyr Val Asn Gly Thr Leu Ser Thr Ser Asp 
    210                 215                 220                 


Pro Ser Gly Lys Val Ser Arg Asp Tyr Gly Glu Ser Asn Val Asn Leu 
225                 230                 235                 240 


Val Ile Gly Ser Glu Gln Asp Gln Ala Lys Cys Tyr Glu Asn Gly Ala 
                245                 250                 255     


Phe Asp Glu Phe Ile Ile Trp Glu Arg Ala Leu Thr Pro Asp Glu Ile 
            260                 265                 270         


Ala Met Tyr Phe Thr Ala Ala Ile Gly Lys His Ala Leu Leu Ser Ser 
        275                 280                 285             


Thr Leu Pro Ser Leu Phe Met Thr Ser Thr Ala Ser Pro Val Met Pro 
    290                 295                 300                 


Thr Asp Ala Tyr His Pro Ile Ile Thr Asn Leu Thr Glu Glu Arg Lys 
305                 310                 315                 320 


Thr Phe Gln Ser Pro Gly Val Ile Leu Ser Tyr Leu Gln Asn Val Ser 
                325                 330                 335     


Leu Ser Leu Pro Ser Lys Ser Leu Ser Glu Gln Thr Ala Leu Asn Leu 
            340                 345                 350         


Thr Lys Thr Phe Leu Lys Ala Val Gly Glu Ile Leu Leu Leu Pro Gly 
        355                 360                 365             


Trp Ile Ala Leu Ser Glu Asp Ser Ala Val Val Leu Ser Leu Ile Asp 
    370                 375                 380                 


Thr Ile Asp Thr Val Met Gly His Val Ser Ser Asn Leu His Gly Ser 
385                 390                 395                 400 


Thr Pro Gln Val Thr Val Glu Gly Ser Ser Ala Met Ala Glu Phe Ser 
                405                 410                 415     


Val Ala Lys Ile Leu Pro Lys Thr Val Asn Ser Ser His Tyr Arg Phe 
            420                 425                 430         


Pro Ala His Gly Gln Ser Phe Ile Gln Ile Pro His Glu Ala Phe His 
        435                 440                 445             


Arg His Ala Trp Ser Thr Val Val Gly Leu Leu Tyr His Ser Met His 
    450                 455                 460                 


Tyr Tyr Leu Asn Asn Ile Trp Pro Ala His Thr Lys Ile Ala Glu Ala 
465                 470                 475                 480 


Met His His Gln Asp Cys Leu Leu Phe Ala Thr Ser His Leu Ile Ser 
                485                 490                 495     


Leu Glu Val Ser Pro Pro Pro Thr Leu Ser Gln Asn Leu Ser Gly Ser 
            500                 505                 510         


Pro Leu Ile Thr Val His Leu Lys His Arg Leu Thr Arg Lys Gln His 
        515                 520                 525             


Ser Glu Ala Thr Asn Ser Ser Asn Arg Val Phe Val Tyr Cys Ala Phe 
    530                 535                 540                 


Leu Asp Phe Ser Ser Gly Glu Gly Val Trp Ser Asn His Gly Cys Ala 
545                 550                 555                 560 


Leu Thr Arg Gly Asn Leu Thr Tyr Ser Val Cys Arg Cys Thr His Leu 
                565                 570                 575     


Thr Asn Phe Ala Ile Leu Met Gln Val Val Pro Leu Glu Leu Ala Arg 
            580                 585                 590         


Gly His Gln Val Ala Leu Ser Ser Ile Ser Tyr Val Gly Cys Ser Leu 
        595                 600                 605             


Ser Val Leu Cys Leu Val Ala Thr Leu Val Thr Phe Ala Val Leu Ser 
    610                 615                 620                 


Ser Val Ser Thr Ile Arg Asn Gln Arg Tyr His Ile His Ala Asn Leu 
625                 630                 635                 640 


Ser Phe Ala Val Leu Val Ala Gln Val Leu Leu Leu Ile Ser Phe Arg 
                645                 650                 655     


Leu Glu Pro Gly Thr Thr Pro Cys Gln Val Met Ala Val Leu Leu His 
            660                 665                 670         


Tyr Phe Phe Leu Ser Ala Phe Ala Trp Met Leu Val Glu Gly Leu His 
        675                 680                 685             


Leu Tyr Ser Met Val Ile Lys Val Phe Gly Ser Glu Asp Ser Lys His 
    690                 695                 700                 


Arg Tyr Tyr Tyr Gly Met Gly Trp Gly Phe Pro Leu Leu Ile Cys Ile 
705                 710                 715                 720 


Ile Ser Leu Ser Phe Ala Met Asp Ser Tyr Gly Thr Ser Asn Asn Cys 
                725                 730                 735     


Trp Leu Ser Leu Ala Ser Gly Ala Ile Trp Ala Phe Val Ala Pro Ala 
            740                 745                 750         


Leu Phe Val Ile Val Val Asn Ile Gly Ile Leu Ile Ala Val Thr Arg 
        755                 760                 765             


Val Ile Ser Gln Ile Ser Ala Asp Asn Tyr Lys Ile His Gly Asp Pro 
    770                 775                 780                 


Ser Ala Phe Lys Leu Thr Ala Lys Ala Val Ala Val Leu Leu Pro Ile 
785                 790                 795                 800 


Leu Gly Thr Ser Trp Val Phe Gly Val Leu Ala Val Asn Gly Cys Ala 
                805                 810                 815     


Val Val Phe Gln Tyr Met Phe Ala Thr Leu Asn Ser Leu Gln Gly Leu 
            820                 825                 830         


Phe Ile Phe Leu Phe His Cys Leu Leu Asn Ser Glu Val Arg Ala Ala 
        835                 840                 845             


Phe Lys His Lys Thr Lys Val Trp Ser Leu Thr Ser Ser Ser Ala Arg 
    850                 855                 860                 


Thr Ser Asn Ala Lys Pro Phe His Ser Asp Leu Met Asn Gly Thr Arg 
865                 870                 875                 880 


Pro Gly Met Ala Ser Thr Lys Leu Ser Pro Trp Asp Lys Ser Ser His 
                885                 890                 895     


Ser Ala His Arg Val Asp Leu Ser Ala Val 
            900                 905     


<210> 19
<211> 27
<212> PRT
<213> Homo sapiens

<400> 19
Gln Thr Ala Leu Asn Leu Thr Lys Thr Phe Leu Lys Ala Val Gly Glu 
1               5                   10                  15      


Ile Leu Leu Leu Pro Gly Trp Ile Ala Leu Ser 
            20                  25          


<210> 20
<211> 27
<212> PRT
<213> Homo sapiens

<400> 20
Met Glu Lys Gly Thr Glu Leu Leu Val Ser Pro Ser Gln Ser Gly Pro 
1               5                   10                  15      


Gly Gly Asp Gln Pro Leu Leu Val Lys His Arg 
            20                  25          


<210> 21
<211> 10
<212> PRT
<213> Homo sapiens

<400> 21
Leu Ile Thr Val His Leu Lys His Arg Leu 
1               5                   10  


<210> 22
<211> 10
<212> PRT
<213> Homo sapiens

<400> 22
Met His Arg Val Cys Phe Leu Ser Phe Gln 
1               5                   10  


<210> 23
<211> 33
<212> PRT
<213> Homo sapiens

<400> 23
Gly Ala Ser Arg Thr His Lys Leu Thr Val Leu Pro Ser Arg Asn Ala 
1               5                   10                  15      


Thr Phe Val Tyr Ser Asn Asp Ser Ala Tyr Ser Asn Leu Ser Ala Thr 
            20                  25                  30          


Val 
    


<210> 24
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 24
gccgctcaat ttatgaatat t                                                 21


