                         SEQUENCE LISTING

<110>  Saint Louis University
       Barranco-Medina, Sergio
       Pozzi, Nicola
       Di Cera, Enrico
 
<120>  THROMBIN-THROMBOMODULIN FUSION PROTEINS AS PROTEIN C ACTIVATORS

<130>  SLU 14-016 (3003528-0118)

<150>  US 62/153,742
<151>  2015-04-28

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala His Val Arg Gly Leu Gln Leu Pro Gly Cys Leu Ala Leu Ala 
1               5                   10                  15      


Ala Leu Cys Ser Leu Val His Ser Gln His Val Phe Leu Ala Pro Gln 
            20                  25                  30          


Gln Ala Arg Ser Leu Leu Gln Arg Val Arg Arg Ala Asn Thr Phe Leu 
        35                  40                  45              


Glu Glu Val Arg Lys Gly Asn Leu Glu Arg Glu Cys Val Glu Glu Thr 
    50                  55                  60                  


Cys Ser Tyr Glu Glu Ala Phe Glu Ala Leu Glu Ser Ser Thr Ala Thr 
65                  70                  75                  80  


Asp Val Phe Trp Ala Lys Tyr Thr Ala Cys Glu Thr Ala Arg Thr Pro 
                85                  90                  95      


Arg Asp Lys Leu Ala Ala Cys Leu Glu Gly Asn Cys Ala Glu Gly Leu 
            100                 105                 110         


Gly Thr Asn Tyr Arg Gly His Val Asn Ile Thr Arg Ser Gly Ile Glu 
        115                 120                 125             


Cys Gln Leu Trp Arg Ser Arg Tyr Pro His Lys Pro Glu Ile Asn Ser 
    130                 135                 140                 


Thr Thr His Pro Gly Ala Asp Leu Gln Glu Asn Phe Cys Arg Asn Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Thr Gly Pro Trp Cys Tyr Thr Thr Asp Pro Thr Val 
                165                 170                 175     


Arg Arg Gln Glu Cys Ser Ile Pro Val Cys Gly Gln Asp Gln Val Thr 
            180                 185                 190         


Val Ala Met Thr Pro Arg Ser Glu Gly Ser Ser Val Asn Leu Ser Pro 
        195                 200                 205             


Pro Leu Glu Gln Cys Val Pro Asp Arg Gly Gln Gln Tyr Gln Gly Arg 
    210                 215                 220                 


Leu Ala Val Thr Thr His Gly Leu Pro Cys Leu Ala Trp Ala Ser Ala 
225                 230                 235                 240 


Gln Ala Lys Ala Leu Ser Lys His Gln Asp Phe Asn Ser Ala Val Gln 
                245                 250                 255     


Leu Val Glu Asn Phe Cys Arg Asn Pro Asp Gly Asp Glu Glu Gly Val 
            260                 265                 270         


Trp Cys Tyr Val Ala Gly Lys Pro Gly Asp Phe Gly Tyr Cys Asp Leu 
        275                 280                 285             


Asn Tyr Cys Glu Glu Ala Val Glu Glu Glu Thr Gly Asp Gly Leu Asp 
    290                 295                 300                 


Glu Asp Ser Asp Arg Ala Ile Glu Gly Arg Thr Ala Thr Ser Glu Tyr 
305                 310                 315                 320 


Gln Thr Phe Phe Asn Pro Arg Thr Phe Gly Ser Gly Glu Ala Asp Cys 
                325                 330                 335     


Gly Leu Arg Pro Leu Phe Glu Lys Lys Ser Leu Glu Asp Lys Thr Glu 
            340                 345                 350         


Arg Glu Leu Leu Glu Ser Tyr Ile Asp Gly Arg Ile Val Glu Gly Ser 
        355                 360                 365             


Asp Ala Glu Ile Gly Met Ser Pro Trp Gln Val Met Leu Phe Arg Lys 
    370                 375                 380                 


Ser Pro Gln Glu Leu Leu Cys Gly Ala Ser Leu Ile Ser Asp Arg Trp 
385                 390                 395                 400 


Val Leu Thr Ala Ala His Cys Leu Leu Tyr Pro Pro Trp Asp Lys Asn 
                405                 410                 415     


Phe Thr Glu Asn Asp Leu Leu Val Arg Ile Gly Lys His Ser Arg Thr 
            420                 425                 430         


Arg Tyr Glu Arg Asn Ile Glu Lys Ile Ser Met Leu Glu Lys Ile Tyr 
        435                 440                 445             


Ile His Pro Arg Tyr Asn Trp Arg Glu Asn Leu Asp Arg Asp Ile Ala 
    450                 455                 460                 


Leu Met Lys Leu Lys Lys Pro Val Ala Phe Ser Asp Tyr Ile His Pro 
465                 470                 475                 480 


Val Cys Leu Pro Asp Arg Glu Thr Ala Ala Ser Leu Leu Gln Ala Gly 
                485                 490                 495     


Tyr Lys Gly Arg Val Thr Gly Trp Gly Asn Leu Lys Glu Thr Trp Thr 
            500                 505                 510         


Ala Asn Val Gly Lys Gly Gln Pro Ser Val Leu Gln Val Val Asn Leu 
        515                 520                 525             


Pro Ile Val Glu Arg Pro Val Cys Lys Asp Ser Thr Arg Ile Arg Ile 
    530                 535                 540                 


Thr Asp Asn Met Phe Cys Ala Gly Tyr Lys Pro Asp Glu Gly Lys Arg 
545                 550                 555                 560 


Gly Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro Phe Val Met Lys Ser 
                565                 570                 575     


Pro Phe Asn Asn Arg Trp Tyr Gln Met Gly Ile Val Ser Trp Gly Glu 
            580                 585                 590         


Gly Cys Asp Arg Asp Gly Lys Tyr Gly Phe Tyr Thr His Val Phe Arg 
        595                 600                 605             


Leu Lys Lys Trp Ile Gln Lys Val Ile Asp Gln Phe Gly Glu 
    610                 615                 620         


<210>  2
<211>  1389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2
atgttcctcg cttgccctgg cttctgggtc ctcgtggtcc taggcagcag ctgggcaggc       60

tgggggaacc taggggctga agcagcaaag cttgaagacc aagtagatcc gcggctcatt      120

gatgggaagg tcgacctgtc acctccattg gagcagtgtg tccctgatcg ggggcagcag      180

taccaggggc gcctggcggt gaccacacat gggctcccct gcctggcctg ggccagcgca      240

caggccaagg ccctgagcaa gcaccaggac ttcaactcag ctgtgcagct ggtggagaac      300

ttctgccgca acccagacgg ggatgaggag ggcgtgtggt gctatgtggc cgggaagcct      360

ggcgactttg ggtactgcga cctcaactat tgtgaggagg ccgtggagga ggagacagga      420

gatgggctgg atgaggactc agacagggcc atcgaagggc gtaccgccac cagtgagtac      480

cagactttct tcaatccgag gacctttggc tcgggagagg cagactgtgg gctgcgacct      540

ctgttcgaga agaagtcgct ggaggacaaa accgaaagag agctcctgga atcctacatc      600

gacgggcgca ttgtggaggg ctcggatgca gagatcggca tgtcaccttg gcaggtgatg      660

cttttccgga agagtcccca ggagctgctg tgtggggcca gcctcatcag tgaccgctgg      720

gtcctcaccg ccgcccactg cctcctgtac ccgccctggg acaagaactt caccgagaat      780

gaccttctgg tgcgcattgg caagcactcc cgcaccaggt acgagcgaaa cattgaaaag      840

atatccatgt tggaaaagat ctacatccac cccaggtaca actggcggga gaacctggac      900

cgggacattg ccctgatgaa gctgaagaag cctgttgcct tcagtgacta cattcaccct      960

gtgtgtctgc ccgacaggga gacggcagcc agcttgctcc aggctggata caaggggcgg     1020

gtgacaggct ggggcaacct gaaggagacg tggacagcca acgttggtaa ggggcagccc     1080

agtgtcctgc aggtggtgaa cctgcccatt gtggagcggc cggtctgcaa ggactccacc     1140

cggatccgca tcactgacaa catgttctgt gctggttaca agcctgatga agggaaacga     1200

ggggatgcct gtgaaggtga cagtggggga ccctttgtca tgaagagccc ctttaacaac     1260

cgctggtacc aaatgggcat cgtctcatgg ggtgaaggct gtgaccggga tgggaaatat     1320

ggcttctaca cacacgtgtt ccgcctgaag aagtggatac agaaggtcat tgatcagttt     1380

ggagagtag                                                             1389


<210>  3
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Met Phe Leu Ala Cys Pro Gly Phe Trp Val Leu Val Val Leu Gly Ser 
1               5                   10                  15      


Ser Trp Ala Gly Trp Gly Asn Leu Gly Ala Glu Ala Ala Lys Leu Glu 
            20                  25                  30          


Asp Gln Val Asp Pro Arg Leu Ile Asp Gly Lys Val Asp Leu Ser Pro 
        35                  40                  45              


Pro Leu Glu Gln Cys Val Pro Asp Arg Gly Gln Gln Tyr Gln Gly Arg 
    50                  55                  60                  


Leu Ala Val Thr Thr His Gly Leu Pro Cys Leu Ala Trp Ala Ser Ala 
65                  70                  75                  80  


Gln Ala Lys Ala Leu Ser Lys His Gln Asp Phe Asn Ser Ala Val Gln 
                85                  90                  95      


Leu Val Glu Asn Phe Cys Arg Asn Pro Asp Gly Asp Glu Glu Gly Val 
            100                 105                 110         


Trp Cys Tyr Val Ala Gly Lys Pro Gly Asp Phe Gly Tyr Cys Asp Leu 
        115                 120                 125             


Asn Tyr Cys Glu Glu Ala Val Glu Glu Glu Thr Gly Asp Gly Leu Asp 
    130                 135                 140                 


Glu Asp Ser Asp Arg Ala Ile Glu Gly Arg Thr Ala Thr Ser Glu Tyr 
145                 150                 155                 160 


Gln Thr Phe Phe Asn Pro Arg Thr Phe Gly Ser Gly Glu Ala Asp Cys 
                165                 170                 175     


Gly Leu Arg Pro Leu Phe Glu Lys Lys Ser Leu Glu Asp Lys Thr Glu 
            180                 185                 190         


Arg Glu Leu Leu Glu Ser Tyr Ile Asp Gly Arg Ile Val Glu Gly Ser 
        195                 200                 205             


Asp Ala Glu Ile Gly Met Ser Pro Trp Gln Val Met Leu Phe Arg Lys 
    210                 215                 220                 


Ser Pro Gln Glu Leu Leu Cys Gly Ala Ser Leu Ile Ser Asp Arg Trp 
225                 230                 235                 240 


Val Leu Thr Ala Ala His Cys Leu Leu Tyr Pro Pro Trp Asp Lys Asn 
                245                 250                 255     


Phe Thr Glu Asn Asp Leu Leu Val Arg Ile Gly Lys His Ser Arg Thr 
            260                 265                 270         


Arg Tyr Glu Arg Asn Ile Glu Lys Ile Ser Met Leu Glu Lys Ile Tyr 
        275                 280                 285             


Ile His Pro Arg Tyr Asn Trp Arg Glu Asn Leu Asp Arg Asp Ile Ala 
    290                 295                 300                 


Leu Met Lys Leu Lys Lys Pro Val Ala Phe Ser Asp Tyr Ile His Pro 
305                 310                 315                 320 


Val Cys Leu Pro Asp Arg Glu Thr Ala Ala Ser Leu Leu Gln Ala Gly 
                325                 330                 335     


Tyr Lys Gly Arg Val Thr Gly Trp Gly Asn Leu Lys Glu Thr Trp Thr 
            340                 345                 350         


Ala Asn Val Gly Lys Gly Gln Pro Ser Val Leu Gln Val Val Asn Leu 
        355                 360                 365             


Pro Ile Val Glu Arg Pro Val Cys Lys Asp Ser Thr Arg Ile Arg Ile 
    370                 375                 380                 


Thr Asp Asn Met Phe Cys Ala Gly Tyr Lys Pro Asp Glu Gly Lys Arg 
385                 390                 395                 400 


Gly Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro Phe Val Met Lys Ser 
                405                 410                 415     


Pro Phe Asn Asn Arg Trp Tyr Gln Met Gly Ile Val Ser Trp Gly Glu 
            420                 425                 430         


Gly Cys Asp Arg Asp Gly Lys Tyr Gly Phe Tyr Thr His Val Phe Arg 
        435                 440                 445             


Leu Lys Lys Trp Ile Gln Lys Val Ile Asp Gln Phe Gly Glu 
    450                 455                 460         


<210>  4
<211>  1389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
atgttcctcg cttgccctgg cttctgggtc ctcgtggtcc taggcagcag ctgggcaggc       60

tgggggaacc taggggctga agcagcaaag cttgaagacc aagtagatcc gcggctcatt      120

gatgggaagg tcgacctgtc acctccattg gagcagtgtg tccctgatcg ggggcagcag      180

taccaggggc gcctggcggt gaccacacat gggctcccct gcctggcctg ggccagcgca      240

caggccaagg ccctgagcaa gcaccaggac ttcaactcag ctgtgcagct ggtggagaac      300

ttctgccgca acccagacgg ggatgaggag ggcgtgtggt gctatgtggc cgggaagcct      360

ggcgactttg ggtactgcga cctcaactat tgtgaggagg ccgtggagga ggagacagga      420

gatgggctgg atgaggactc agacagggcc atcgaagggc gtaccgccac cagtgagtac      480

cagactttct tcgacgggag gacctttggc tcgggagagg cagactgtgg gctgcgacct      540

ctgttcgaga agaagtcgct ggaggacaaa accgaaagag agctcctgga atcctacatc      600

gacgggcgca ttgtggaggg ctcggatgca gagatcggca tgtcaccttg gcaggtgatg      660

cttttccgga agagtcccca ggagctgctg tgtggggcca gcctcatcag tgaccgctgg      720

gtcctcaccg ccgcccactg cctcctgtac ccgccctggg acaagaactt caccgagaat      780

gaccttctgg tgcgcattgg caagcactcc cgcaccaggt acgagcgaaa cattgaaaag      840

atatccatgt tggaaaagat ctacatccac cccaggtaca actggcggga gaacctggac      900

cgggacattg ccctgatgaa gctgaagaag cctgttgcct tcagtgacta cattcaccct      960

gtgtgtctgc ccgacaggga gacggcagcc agcttgctcc aggctggata caaggggcgg     1020

gtgacaggct ggggcaacct gaaggagacg tggacagcca acgttggtaa ggggcagccc     1080

agtgtcctgc aggtggtgaa cctgcccatt gtggagcggc cggtctgcaa ggactccacc     1140

cggatccgca tcactgacaa catgttctgt gctggttaca agcctgatga agggaaacga     1200

ggggatgcct gtgaaggtga cagtggggga ccctttgtca tgaagagccc ctttaacaac     1260

cgctggtacc aaatgggcat cgtctcatgg ggtgaaggct gtgaccggga tgggaaatat     1320

ggcttctaca cacacgtgtt ccgcctgaag aagtggatac agaaggtcat tgatcagttt     1380

ggagagtag                                                             1389


<210>  5
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Met Phe Leu Ala Cys Pro Gly Phe Trp Val Leu Val Val Leu Gly Ser 
1               5                   10                  15      


Ser Trp Ala Gly Trp Gly Asn Leu Gly Ala Glu Ala Ala Lys Leu Glu 
            20                  25                  30          


Asp Gln Val Asp Pro Arg Leu Ile Asp Gly Lys Val Asp Leu Ser Pro 
        35                  40                  45              


Pro Leu Glu Gln Cys Val Pro Asp Arg Gly Gln Gln Tyr Gln Gly Arg 
    50                  55                  60                  


Leu Ala Val Thr Thr His Gly Leu Pro Cys Leu Ala Trp Ala Ser Ala 
65                  70                  75                  80  


Gln Ala Lys Ala Leu Ser Lys His Gln Asp Phe Asn Ser Ala Val Gln 
                85                  90                  95      


Leu Val Glu Asn Phe Cys Arg Asn Pro Asp Gly Asp Glu Glu Gly Val 
            100                 105                 110         


Trp Cys Tyr Val Ala Gly Lys Pro Gly Asp Phe Gly Tyr Cys Asp Leu 
        115                 120                 125             


Asn Tyr Cys Glu Glu Ala Val Glu Glu Glu Thr Gly Asp Gly Leu Asp 
    130                 135                 140                 


Glu Asp Ser Asp Arg Ala Ile Glu Gly Arg Thr Ala Thr Ser Glu Tyr 
145                 150                 155                 160 


Gln Thr Phe Phe Asp Gly Arg Thr Phe Gly Ser Gly Glu Ala Asp Cys 
                165                 170                 175     


Gly Leu Arg Pro Leu Phe Glu Lys Lys Ser Leu Glu Asp Lys Thr Glu 
            180                 185                 190         


Arg Glu Leu Leu Glu Ser Tyr Ile Asp Gly Arg Ile Val Glu Gly Ser 
        195                 200                 205             


Asp Ala Glu Ile Gly Met Ser Pro Trp Gln Val Met Leu Phe Arg Lys 
    210                 215                 220                 


Ser Pro Gln Glu Leu Leu Cys Gly Ala Ser Leu Ile Ser Asp Arg Trp 
225                 230                 235                 240 


Val Leu Thr Ala Ala His Cys Leu Leu Tyr Pro Pro Trp Asp Lys Asn 
                245                 250                 255     


Phe Thr Glu Asn Asp Leu Leu Val Arg Ile Gly Lys His Ser Arg Thr 
            260                 265                 270         


Arg Tyr Glu Arg Asn Ile Glu Lys Ile Ser Met Leu Glu Lys Ile Tyr 
        275                 280                 285             


Ile His Pro Arg Tyr Asn Trp Arg Glu Asn Leu Asp Arg Asp Ile Ala 
    290                 295                 300                 


Leu Met Lys Leu Lys Lys Pro Val Ala Phe Ser Asp Tyr Ile His Pro 
305                 310                 315                 320 


Val Cys Leu Pro Asp Arg Glu Thr Ala Ala Ser Leu Leu Gln Ala Gly 
                325                 330                 335     


Tyr Lys Gly Arg Val Thr Gly Trp Gly Asn Leu Lys Glu Thr Trp Thr 
            340                 345                 350         


Ala Asn Val Gly Lys Gly Gln Pro Ser Val Leu Gln Val Val Asn Leu 
        355                 360                 365             


Pro Ile Val Glu Arg Pro Val Cys Lys Asp Ser Thr Arg Ile Arg Ile 
    370                 375                 380                 


Thr Asp Asn Met Phe Cys Ala Gly Tyr Lys Pro Asp Glu Gly Lys Arg 
385                 390                 395                 400 


Gly Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro Phe Val Met Lys Ser 
                405                 410                 415     


Pro Phe Asn Asn Arg Trp Tyr Gln Met Gly Ile Val Ser Trp Gly Glu 
            420                 425                 430         


Gly Cys Asp Arg Asp Gly Lys Tyr Gly Phe Tyr Thr His Val Phe Arg 
        435                 440                 445             


Leu Lys Lys Trp Ile Gln Lys Val Ile Asp Gln Phe Gly Glu 
    450                 455                 460         


<210>  6
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6
gtggagcccg tggacccgtg cttcgccaac tgcgagtacc agtgccagcc cctgaaccaa       60

actagctacc tctgcgtctg cgccgagggc ttcgcgccca ttccccacga gccgcacagg      120

tgccagatgt tttgcaacca gactgcctgt ccagccgact gcgaccccaa cacccaggct      180

agctgtgagt gccctgaagg ctacatcctg gacgacggtt tcatctgcac ggacatcgac      240

gagtgcgaaa acggcggctt ctgctccggg gtgtgccaca acctccccgg taccttcgag      300

tgcatctgcg ggcccgactc ggcccttgcc cgccacattg gcaccgactg tgactccggc      360


<210>  7
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Val Glu Pro Val Asp Pro Cys Phe Ala Asn Cys Glu Tyr Gln Cys Gln 
1               5                   10                  15      


Pro Leu Asn Gln Thr Ser Tyr Leu Cys Val Cys Ala Glu Gly Phe Ala 
            20                  25                  30          


Pro Ile Pro His Glu Pro His Arg Cys Gln Met Phe Cys Asn Gln Thr 
        35                  40                  45              


Ala Cys Pro Ala Asp Cys Asp Pro Asn Thr Gln Ala Ser Cys Glu Cys 
    50                  55                  60                  


Pro Glu Gly Tyr Ile Leu Asp Asp Gly Phe Ile Cys Thr Asp Ile Asp 
65                  70                  75                  80  


Glu Cys Glu Asn Gly Gly Phe Cys Ser Gly Val Cys His Asn Leu Pro 
                85                  90                  95      


Gly Thr Phe Glu Cys Ile Cys Gly Pro Asp Ser Ala Leu Ala Arg His 
            100                 105                 110         


Ile Gly Thr Asp Cys Asp Ser Gly 
        115                 120 


<210>  8
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8
gtggagcccg tggacccgtg cttcagagcc aactgcgagt accagtgcca gcccctgaac       60

caaactagct acctctgcgt ctgcgccgag ggcttcgcgc ccattcccca cgagccgcac      120

aggtgccaga tgttttgcaa ccagactgcc tgtccagccg actgcgaccc caacacccag      180

gctagctgtg agtgccctga aggctacatc ctggacgacg gtttcatctg cacggacatc      240

gacgagtgcg aaaacggcgg cttctgctcc ggggtgtgcc acaacctccc cggtaccttc      300

gagtgcatct gcgggcccga ctcggccctt gcccgccaca ttggcaccga ctgtgactcc      360

ggc                                                                    363


<210>  9
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Val Glu Pro Val Asp Pro Cys Phe Arg Ala Asn Cys Glu Tyr Gln Cys 
1               5                   10                  15      


Gln Pro Leu Asn Gln Thr Ser Tyr Leu Cys Val Cys Ala Glu Gly Phe 
            20                  25                  30          


Ala Pro Ile Pro His Glu Pro His Arg Cys Gln Met Phe Cys Asn Gln 
        35                  40                  45              


Thr Ala Cys Pro Ala Asp Cys Asp Pro Asn Thr Gln Ala Ser Cys Glu 
    50                  55                  60                  


Cys Pro Glu Gly Tyr Ile Leu Asp Asp Gly Phe Ile Cys Thr Asp Ile 
65                  70                  75                  80  


Asp Glu Cys Glu Asn Gly Gly Phe Cys Ser Gly Val Cys His Asn Leu 
                85                  90                  95      


Pro Gly Thr Phe Glu Cys Ile Cys Gly Pro Asp Ser Ala Leu Ala Arg 
            100                 105                 110         


His Ile Gly Thr Asp Cys Asp Ser Gly 
        115                 120     


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Gly Gly Gly Gly Gly Gly Gly 
1               5           


<210>  11
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Gly Gly Gly Ser Ser Ser Ala Gly Gly Gly Ser Ser Ser Gly Gly Gly 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Gly Gly Gly Ser Ser Ser Ala Gly Gly Gly Ser Ser Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Ser Ser Ala Gly Gly Gly Ser Ser Ser Gly Gly Gly Gly 
            20                  25                  30      


<210>  13
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Gly Gly Gly Ser Ser Ser Ala Gly Gly Gly Ser Ser Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Ser Ser Ala Gly Gly Gly Ser Ser Ser Gly Gly Gly Gly Ala 
            20                  25                  30          


Ser Ser Ser Gly Ser Ala Gly Ser Ser 
        35                  40      


<210>  14
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Gly Gly Gly Ser Ser Ser Ala Gly Gly Gly Ser Ser Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Ser Ser Ala Gly Gly Gly Ser Ser Ser Gly Gly Gly Gly Ala 
            20                  25                  30          


Ser Ser Ser Gly Ser Ala Gly Ser Ser Gly Gly Gly Gly Ala Ser Ser 
        35                  40                  45              


Ser Gly Ser Ala Gly Ser Ser 
    50                  55  


<210>  15
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Gly Gly Gly Ser Ser Ser Ala Gly Gly Gly Ser Ser Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Ser Ser Ala Gly Gly Gly Ser Ser Ser Gly Gly Gly Gly Ser 
            20                  25                  30          


Ser Ser Ala Gly Gly Gly Ser Ser Ser Gly Gly Gly Gly Ser Ser Ser 
        35                  40                  45              


Ala Gly Gly Gly Ser Ser Ser Gly Gly Gly Gly Ala Ser Ser Ser Gly 
    50                  55                  60                  


Ser Ala Gly Ser Ser 
65                  


<210>  16
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Leu Glu Asp Gln Val Asp Pro Arg Leu Ile Asp Gly Lys 
1               5                   10              


<210>  17
<211>  1845
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
atgttcctcg cttgccctgg cttctgggtc ctcgtggtcc taggcagcag ctgggcaggc       60

tgggggaacc taggggctga agcagcaaag cttgaagacc aagtagatcc gcggctcatt      120

gatgggaagg tcgacctgtc acctccattg gagcagtgtg tccctgatcg ggggcagcag      180

taccaggggc gcctggcggt gaccacacat gggctcccct gcctggcctg ggccagcgca      240

caggccaagg ccctgagcaa gcaccaggac ttcaactcag ctgtgcagct ggtggagaac      300

ttctgccgca acccagacgg ggatgaggag ggcgtgtggt gctatgtggc cgggaagcct      360

ggcgactttg ggtactgcga cctcaactat tgtgaggagg ccgtggagga ggagacagga      420

gatgggctgg atgaggactc agacagggcc atcgaagggc gtaccgccac cagtgagtac      480

cagactttct tcgacgggag gacctttggc tcgggagagg cagactgtgg gctgcgacct      540

ctgttcgaga agaagtcgct ggaggacaaa accgaaagag agctcctgga atcctacatc      600

gacgggcgca ttgtggaggg ctcggatgca gagatcggca tgtcaccttg gcaggtgatg      660

cttttccgga agagtcccca ggagctgctg tgtggggcca gcctcatcag tgaccgctgg      720

gtcctcaccg ccgcccactg cctcctgtac ccgccctggg acaagaactt caccgagaat      780

gaccttctgg tgcgcattgg caagcactcc cgcaccaggt acgagcgaaa cattgaaaag      840

atatccatgt tggaaaagat ctacatccac cccaggtaca actggcggga gaacctggac      900

cgggacattg ccctgatgaa gctgaagaag cctgttgcct tcagtgacta cattcaccct      960

gtgtgtctgc ccgacaggga gacggcagcc agcttgctcc aggctggata caaggggcgg     1020

gtgacaggct ggggcaacct gaaggagacg tggacagcca acgttggtaa ggggcagccc     1080

agtgtcctgc aggtggtgaa cctgcccatt gtggagcggc cggtctgcaa ggactccacc     1140

cggatccgca tcactgacaa catgttctgt gctggttaca agcctgatga agggaaacga     1200

ggggatgcct gtgaaggtga cagtggggga ccctttgtca tgaagagccc ctttaacaac     1260

cgctggtacc aaatgggcat cgtctcatgg ggtgaaggct gtgaccggga tgggaaatat     1320

ggcttctaca cacacgtgtt ccgcctgaag aagtggatac agaaggtcat tgatcagttt     1380

ggagagggag gtggatcttc ttctgccggt ggtggttcat cttctggtgg aggtggatct     1440

tcttctgccg gtggtggttc atcttctggt ggaggtggag tggagcccgt ggacccgtgc     1500

ttcagagcca actgcgagta ccagtgccag cccctgaacc aaactagcta cctctgcgtc     1560

tgcgccgagg gcttcgcgcc cattccccac gagccgcaca ggtgccagat gttttgcaac     1620

cagactgcct gtccagccga ctgcgacccc aacacccagg ctagctgtga gtgccctgaa     1680

ggctacatcc tggacgacgg tttcatctgc acggacatcg acgagtgcga aaacggcggc     1740

ttctgctccg gggtgtgcca caacctcccc ggtaccttcg agtgcatctg cgggcccgac     1800

tcggcccttg cccgccacat tggcaccgac tgtgactccg gctaa                     1845


<210>  18
<211>  611
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Met Phe Leu Ala Cys Pro Gly Phe Trp Val Leu Val Val Leu Gly Ser 
1               5                   10                  15      


Ser Trp Ala Gly Trp Gly Asn Leu Gly Ala Glu Ala Ala Lys Leu Glu 
            20                  25                  30          


Asp Gln Val Asp Pro Arg Leu Ile Asp Gly Lys Val Asp Leu Ser Pro 
        35                  40                  45              


Pro Leu Glu Gln Cys Val Pro Asp Arg Gly Gln Gln Tyr Gln Gly Arg 
    50                  55                  60                  


Leu Ala Val Thr Thr His Gly Leu Pro Cys Leu Ala Trp Ala Ser Ala 
65                  70                  75                  80  


Gln Ala Lys Ala Leu Ser Lys His Gln Asp Phe Asn Ser Ala Val Gln 
                85                  90                  95      


Leu Val Glu Asn Phe Cys Arg Asn Pro Asp Gly Asp Glu Glu Gly Val 
            100                 105                 110         


Trp Cys Tyr Val Ala Gly Lys Pro Gly Asp Phe Gly Tyr Cys Asp Leu 
        115                 120                 125             


Asn Tyr Cys Glu Glu Ala Val Glu Glu Glu Thr Gly Asp Gly Leu Asp 
    130                 135                 140                 


Glu Asp Ser Asp Arg Ala Ile Glu Gly Arg Thr Ala Thr Ser Glu Tyr 
145                 150                 155                 160 


Gln Thr Phe Phe Asp Gly Arg Thr Phe Gly Ser Gly Glu Ala Asp Cys 
                165                 170                 175     


Gly Leu Arg Pro Leu Phe Glu Lys Lys Ser Leu Glu Asp Lys Glu Arg 
            180                 185                 190         


Glu Leu Leu Glu Ser Tyr Ile Asp Gly Arg Ile Val Glu Gly Ser Asp 
        195                 200                 205             


Ala Glu Ile Gly Met Ser Pro Trp Gln Val Met Leu Phe Arg Lys Ser 
    210                 215                 220                 


Pro Gln Glu Leu Leu Cys Gly Ala Ser Leu Ile Ser Asp Arg Trp Val 
225                 230                 235                 240 


Leu Thr Ala Ala His Cys Leu Leu Tyr Pro Pro Trp Asp Lys Asn Phe 
                245                 250                 255     


Thr Glu Asn Asp Leu Leu Val Arg Ile Gly Lys His Ser Arg Thr Arg 
            260                 265                 270         


Tyr Glu Arg Asn Ile Glu Lys Ile Ser Met Leu Glu Lys Ile Tyr Ile 
        275                 280                 285             


His Pro Arg Tyr Asn Trp Arg Glu Asn Leu Asp Arg Asp Ile Ala Leu 
    290                 295                 300                 


Met Lys Leu Lys Lys Pro Val Ala Phe Ser Asp Tyr Ile His Pro Val 
305                 310                 315                 320 


Cys Leu Pro Asp Arg Glu Thr Ala Ala Ser Leu Leu Gln Ala Gly Tyr 
                325                 330                 335     


Lys Gly Arg Val Thr Gly Trp Gly Asn Leu Lys Glu Thr Trp Thr Ala 
            340                 345                 350         


Asn Val Gly Lys Gly Gln Pro Ser Val Leu Gln Val Val Asn Leu Pro 
        355                 360                 365             


Ile Val Glu Arg Pro Val Cys Lys Asp Ser Thr Arg Ile Arg Ile Thr 
    370                 375                 380                 


Asp Asn Met Phe Cys Ala Gly Tyr Lys Pro Asp Glu Gly Lys Arg Gly 
385                 390                 395                 400 


Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro Phe Val Met Lys Ser Pro 
                405                 410                 415     


Phe Asn Asn Arg Trp Tyr Gln Met Gly Ile Val Ser Trp Gly Glu Gly 
            420                 425                 430         


Cys Asp Arg Asp Gly Lys Tyr Gly Phe Tyr Thr His Val Phe Arg Leu 
        435                 440                 445             


Lys Lys Trp Ile Gln Lys Val Ile Asp Gln Phe Gly Gly Gly Ser Ser 
    450                 455                 460                 


Ser Ala Gly Gly Gly Ser Ser Ser Gly Gly Gly Gly Ser Ser Ser Ala 
465                 470                 475                 480 


Gly Gly Gly Ser Ser Ser Gly Gly Gly Gly Val Glu Pro Val Asp Pro 
                485                 490                 495     


Cys Phe Arg Ala Asn Cys Glu Tyr Gln Cys Gln Pro Leu Asn Gln Thr 
            500                 505                 510         


Ser Tyr Leu Cys Val Cys Ala Glu Gly Phe Ala Pro Ile Pro His Glu 
        515                 520                 525             


Pro His Arg Cys Gln Met Phe Cys Asn Gln Thr Ala Cys Pro Ala Asp 
    530                 535                 540                 


Cys Asp Pro Asn Thr Gln Ala Ser Cys Glu Cys Pro Glu Gly Tyr Ile 
545                 550                 555                 560 


Leu Asp Asp Gly Phe Ile Cys Thr Asp Ile Asp Glu Cys Glu Asn Gly 
                565                 570                 575     


Gly Phe Cys Ser Gly Val Cys His Asn Leu Pro Gly Thr Phe Glu Cys 
            580                 585                 590         


Ile Cys Gly Pro Asp Ser Ala Leu Ala Arg His Ile Gly Thr Asp Cys 
        595                 600                 605             


Asp Ser Gly 
    610     


<210>  19
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Thr Phe Gly Ser Gly Glu Ala Asp Cys Gly Leu Arg Pro Leu Phe Glu 
1               5                   10                  15      


Lys Lys Ser Leu Glu Asp Lys Glu Arg Glu Leu Leu Glu Ser Tyr Ile 
            20                  25                  30          


Asp Gly Arg Ile Val Glu Gly Ser Asp Ala Glu Ile Gly Met Ser Pro 
        35                  40                  45              


Trp Gln Val Met Leu Phe Arg Lys Ser Pro Gln Glu Leu Leu Cys Gly 
    50                  55                  60                  


Ala Ser Leu Ile Ser Asp Arg Trp Val Leu Thr Ala Ala His Cys Leu 
65                  70                  75                  80  


Leu Tyr Pro Pro Trp Asp Lys Asn Phe Thr Glu Asn Asp Leu Leu Val 
                85                  90                  95      


Arg Ile Gly Lys His Ser Arg Thr Arg Tyr Glu Arg Asn Ile Glu Lys 
            100                 105                 110         


Ile Ser Met Leu Glu Lys Ile Tyr Ile His Pro Arg Tyr Asn Trp Arg 
        115                 120                 125             


Glu Asn Leu Asp Arg Asp Ile Ala Leu Met Lys Leu Lys Lys Pro Val 
    130                 135                 140                 


Ala Phe Ser Asp Tyr Ile His Pro Val Cys Leu Pro Asp Arg Glu Thr 
145                 150                 155                 160 


Ala Ala Ser Leu Leu Gln Ala Gly Tyr Lys Gly Arg Val Thr Gly Trp 
                165                 170                 175     


Gly Asn Leu Lys Glu Thr Trp Thr Ala Asn Val Gly Lys Gly Gln Pro 
            180                 185                 190         


Ser Val Leu Gln Val Val Asn Leu Pro Ile Val Glu Arg Pro Val Cys 
        195                 200                 205             


Lys Asp Ser Thr Arg Ile Arg Ile Thr Asp Asn Met Phe Cys Ala Gly 
    210                 215                 220                 


Tyr Lys Pro Asp Glu Gly Lys Arg Gly Asp Ala Cys Glu Gly Asp Ser 
225                 230                 235                 240 


Gly Gly Pro Phe Val Met Lys Ser Pro Phe Asn Asn Arg Trp Tyr Gln 
                245                 250                 255     


Met Gly Ile Val Ser Trp Gly Glu Gly Cys Asp Arg Asp Gly Lys Tyr 
            260                 265                 270         


Gly Phe Tyr Thr His Val Phe Arg Leu Lys Lys Trp Ile Gln Lys Val 
        275                 280                 285             


Ile Asp Gln Phe Gly Gly Gly Ser Ser Ser Ala Gly Gly Gly Ser Ser 
    290                 295                 300                 


Ser Gly Gly Gly Gly Ser Ser Ser Ala Gly Gly Gly Ser Ser Ser Gly 
305                 310                 315                 320 


Gly Gly Gly Val Glu Pro Val Asp Pro Cys Phe Arg Ala Asn Cys Glu 
                325                 330                 335     


Tyr Gln Cys Gln Pro Leu Asn Gln Thr Ser Tyr Leu Cys Val Cys Ala 
            340                 345                 350         


Glu Gly Phe Ala Pro Ile Pro His Glu Pro His Arg Cys Gln Met Phe 
        355                 360                 365             


Cys Asn Gln Thr Ala Cys Pro Ala Asp Cys Asp Pro Asn Thr Gln Ala 
    370                 375                 380                 


Ser Cys Glu Cys Pro Glu Gly Tyr Ile Leu Asp Asp Gly Phe Ile Cys 
385                 390                 395                 400 


Thr Asp Ile Asp Glu Cys Glu Asn Gly Gly Phe Cys Ser Gly Val Cys 
                405                 410                 415     


His Asn Leu Pro Gly Thr Phe Glu Cys Ile Cys Gly Pro Asp Ser Ala 
            420                 425                 430         


Leu Ala Arg His Ile Gly Thr Asp Cys Asp Ser Gly 
        435                 440                 


<210>  20
<211>  1845
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20
atgttcctcg cttgccctgg cttctgggtc ctcgtggtcc taggcagcag ctgggcaggc       60

tgggggaacc taggggctga agcagcaaag cttgaagacc aagtagatcc gcggctcatt      120

gatgggaagg tcgacctgtc acctccattg gagcagtgtg tccctgatcg ggggcagcag      180

taccaggggc gcctggcggt gaccacacat gggctcccct gcctggcctg ggccagcgca      240

caggccaagg ccctgagcaa gcaccaggac ttcaactcag ctgtgcagct ggtggagaac      300

ttctgccgca acccagacgg ggatgaggag ggcgtgtggt gctatgtggc cgggaagcct      360

ggcgactttg ggtactgcga cctcaactat tgtgaggagg ccgtggagga ggagacagga      420

gatgggctgg atgaggactc agacagggcc atcgaagggc gtaccgccac cagtgagtac      480

cagactttct tcgacgggag gacctttggc tcgggagagg cagactgtgg gctgcgacct      540

ctgttcgaga agaagtcgct ggaggacaaa accgaaagag agctcctgga atcctacatc      600

gacgggcgca ttgtggaggg ctcggatgca gagatcggca tgtcaccttg gcaggtgatg      660

cttttccgga agagtcccca ggagctgctg tgtggggcca gcctcatcag tgaccgctgg      720

gtcctcaccg ccgcccactg cctcctgtac ccgccctggg acaagaactt caccgagaat      780

gaccttctgg tgcgcattgg caagcactcc cgcaccaggt acgagcgaaa cattgaaaag      840

atatccatgt tggaaaagat ctacatccac cccaggtaca actggcggga gaacctggac      900

cgggacattg ccctgatgaa gctgaagaag cctgttgcct tcagtgacta cattcaccct      960

gtgtgtctgc ccgacaggga gacggcagcc agcttgctcc aggctggata caaggggcgg     1020

gtgacaggct ggggcaacct gaaggagacg tggacagcca acgttggtaa ggggcagccc     1080

agtgtcctgc aggtggtgaa cctgcccatt gtggagcggc cggtctgcaa ggactccacc     1140

cggatccgca tcactgacaa catgttctgt gctggttaca agcctgatga agggaaacga     1200

ggggatgcct gtgaaggtga cagtggggga ccctttgtca tgaagagccc ctttaacaac     1260

cgctggtacc aaatgggcat cgtctcagcg ggtgcaggct gtgaccggga tgggaaatat     1320

ggcttctaca cacacgtgtt ccgcctgaag aagtggatac agaaggtcat tgatcagttt     1380

ggagagggag gtggatcttc ttctgccggt ggtggttcat cttctggtgg aggtggatct     1440

tcttctgccg gtggtggttc atcttctggt ggaggtggag tggagcccgt ggacccgtgc     1500

ttcagagcca actgcgagta ccagtgccag cccctgaacc aaactagcta cctctgcgtc     1560

tgcgccgagg gcttcgcgcc cattccccac gagccgcaca ggtgccagat gttttgcaac     1620

cagactgcct gtccagccga ctgcgacccc aacacccagg ctagctgtga gtgccctgaa     1680

ggctacatcc tggacgacgg tttcatctgc acggacatcg acgagtgcga aaacggcggc     1740

ttctgctccg gggtgtgcca caacctcccc ggtaccttcg agtgcatctg cgggcccgac     1800

tcggcccttg cccgccacat tggcaccgac tgtgactccg gctaa                     1845


<210>  21
<211>  611
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Met Phe Leu Ala Cys Pro Gly Phe Trp Val Leu Val Val Leu Gly Ser 
1               5                   10                  15      


Ser Trp Ala Gly Trp Gly Asn Leu Gly Ala Glu Ala Ala Lys Leu Glu 
            20                  25                  30          


Asp Gln Val Asp Pro Arg Leu Ile Asp Gly Lys Val Asp Leu Ser Pro 
        35                  40                  45              


Pro Leu Glu Gln Cys Val Pro Asp Arg Gly Gln Gln Tyr Gln Gly Arg 
    50                  55                  60                  


Leu Ala Val Thr Thr His Gly Leu Pro Cys Leu Ala Trp Ala Ser Ala 
65                  70                  75                  80  


Gln Ala Lys Ala Leu Ser Lys His Gln Asp Phe Asn Ser Ala Val Gln 
                85                  90                  95      


Leu Val Glu Asn Phe Cys Arg Asn Pro Asp Gly Asp Glu Glu Gly Val 
            100                 105                 110         


Trp Cys Tyr Val Ala Gly Lys Pro Gly Asp Phe Gly Tyr Cys Asp Leu 
        115                 120                 125             


Asn Tyr Cys Glu Glu Ala Val Glu Glu Glu Thr Gly Asp Gly Leu Asp 
    130                 135                 140                 


Glu Asp Ser Asp Arg Ala Ile Glu Gly Arg Thr Ala Thr Ser Glu Tyr 
145                 150                 155                 160 


Gln Thr Phe Phe Asp Gly Arg Thr Phe Gly Ser Gly Glu Ala Asp Cys 
                165                 170                 175     


Gly Leu Arg Pro Leu Phe Glu Lys Lys Ser Leu Glu Asp Lys Glu Arg 
            180                 185                 190         


Glu Leu Leu Glu Ser Tyr Ile Asp Gly Arg Ile Val Glu Gly Ser Asp 
        195                 200                 205             


Ala Glu Ile Gly Met Ser Pro Trp Gln Val Met Leu Phe Arg Lys Ser 
    210                 215                 220                 


Pro Gln Glu Leu Leu Cys Gly Ala Ser Leu Ile Ser Asp Arg Trp Val 
225                 230                 235                 240 


Leu Thr Ala Ala His Cys Leu Leu Tyr Pro Pro Trp Asp Lys Asn Phe 
                245                 250                 255     


Thr Glu Asn Asp Leu Leu Val Arg Ile Gly Lys His Ser Arg Thr Arg 
            260                 265                 270         


Tyr Glu Arg Asn Ile Glu Lys Ile Ser Met Leu Glu Lys Ile Tyr Ile 
        275                 280                 285             


His Pro Arg Tyr Asn Trp Arg Glu Asn Leu Asp Arg Asp Ile Ala Leu 
    290                 295                 300                 


Met Lys Leu Lys Lys Pro Val Ala Phe Ser Asp Tyr Ile His Pro Val 
305                 310                 315                 320 


Cys Leu Pro Asp Arg Glu Thr Ala Ala Ser Leu Leu Gln Ala Gly Tyr 
                325                 330                 335     


Lys Gly Arg Val Thr Gly Trp Gly Asn Leu Lys Glu Thr Trp Thr Ala 
            340                 345                 350         


Asn Val Gly Lys Gly Gln Pro Ser Val Leu Gln Val Val Asn Leu Pro 
        355                 360                 365             


Ile Val Glu Arg Pro Val Cys Lys Asp Ser Thr Arg Ile Arg Ile Thr 
    370                 375                 380                 


Asp Asn Met Phe Cys Ala Gly Tyr Lys Pro Asp Glu Gly Lys Arg Gly 
385                 390                 395                 400 


Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro Phe Val Met Lys Ser Pro 
                405                 410                 415     


Phe Asn Asn Arg Trp Tyr Gln Met Gly Ile Val Ser Ala Gly Ala Gly 
            420                 425                 430         


Cys Asp Arg Asp Gly Lys Tyr Gly Phe Tyr Thr His Val Phe Arg Leu 
        435                 440                 445             


Lys Lys Trp Ile Gln Lys Val Ile Asp Gln Phe Gly Gly Gly Ser Ser 
    450                 455                 460                 


Ser Ala Gly Gly Gly Ser Ser Ser Gly Gly Gly Gly Ser Ser Ser Ala 
465                 470                 475                 480 


Gly Gly Gly Ser Ser Ser Gly Gly Gly Gly Val Glu Pro Val Asp Pro 
                485                 490                 495     


Cys Phe Arg Ala Asn Cys Glu Tyr Gln Cys Gln Pro Leu Asn Gln Thr 
            500                 505                 510         


Ser Tyr Leu Cys Val Cys Ala Glu Gly Phe Ala Pro Ile Pro His Glu 
        515                 520                 525             


Pro His Arg Cys Gln Met Phe Cys Asn Gln Thr Ala Cys Pro Ala Asp 
    530                 535                 540                 


Cys Asp Pro Asn Thr Gln Ala Ser Cys Glu Cys Pro Glu Gly Tyr Ile 
545                 550                 555                 560 


Leu Asp Asp Gly Phe Ile Cys Thr Asp Ile Asp Glu Cys Glu Asn Gly 
                565                 570                 575     


Gly Phe Cys Ser Gly Val Cys His Asn Leu Pro Gly Thr Phe Glu Cys 
            580                 585                 590         


Ile Cys Gly Pro Asp Ser Ala Leu Ala Arg His Ile Gly Thr Asp Cys 
        595                 600                 605             


Asp Ser Gly 
    610     


<210>  22
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Thr Phe Gly Ser Gly Glu Ala Asp Cys Gly Leu Arg Pro Leu Phe Glu 
1               5                   10                  15      


Lys Lys Ser Leu Glu Asp Lys Glu Arg Glu Leu Leu Glu Ser Tyr Ile 
            20                  25                  30          


Asp Gly Arg Ile Val Glu Gly Ser Asp Ala Glu Ile Gly Met Ser Pro 
        35                  40                  45              


Trp Gln Val Met Leu Phe Arg Lys Ser Pro Gln Glu Leu Leu Cys Gly 
    50                  55                  60                  


Ala Ser Leu Ile Ser Asp Arg Trp Val Leu Thr Ala Ala His Cys Leu 
65                  70                  75                  80  


Leu Tyr Pro Pro Trp Asp Lys Asn Phe Thr Glu Asn Asp Leu Leu Val 
                85                  90                  95      


Arg Ile Gly Lys His Ser Arg Thr Arg Tyr Glu Arg Asn Ile Glu Lys 
            100                 105                 110         


Ile Ser Met Leu Glu Lys Ile Tyr Ile His Pro Arg Tyr Asn Trp Arg 
        115                 120                 125             


Glu Asn Leu Asp Arg Asp Ile Ala Leu Met Lys Leu Lys Lys Pro Val 
    130                 135                 140                 


Ala Phe Ser Asp Tyr Ile His Pro Val Cys Leu Pro Asp Arg Glu Thr 
145                 150                 155                 160 


Ala Ala Ser Leu Leu Gln Ala Gly Tyr Lys Gly Arg Val Thr Gly Trp 
                165                 170                 175     


Gly Asn Leu Lys Glu Thr Trp Thr Ala Asn Val Gly Lys Gly Gln Pro 
            180                 185                 190         


Ser Val Leu Gln Val Val Asn Leu Pro Ile Val Glu Arg Pro Val Cys 
        195                 200                 205             


Lys Asp Ser Thr Arg Ile Arg Ile Thr Asp Asn Met Phe Cys Ala Gly 
    210                 215                 220                 


Tyr Lys Pro Asp Glu Gly Lys Arg Gly Asp Ala Cys Glu Gly Asp Ser 
225                 230                 235                 240 


Gly Gly Pro Phe Val Met Lys Ser Pro Phe Asn Asn Arg Trp Tyr Gln 
                245                 250                 255     


Met Gly Ile Val Ser Ala Gly Ala Gly Cys Asp Arg Asp Gly Lys Tyr 
            260                 265                 270         


Gly Phe Tyr Thr His Val Phe Arg Leu Lys Lys Trp Ile Gln Lys Val 
        275                 280                 285             


Ile Asp Gln Phe Gly Gly Gly Ser Ser Ser Ala Gly Gly Gly Ser Ser 
    290                 295                 300                 


Ser Gly Gly Gly Gly Ser Ser Ser Ala Gly Gly Gly Ser Ser Ser Gly 
305                 310                 315                 320 


Gly Gly Gly Val Glu Pro Val Asp Pro Cys Phe Arg Ala Asn Cys Glu 
                325                 330                 335     


Tyr Gln Cys Gln Pro Leu Asn Gln Thr Ser Tyr Leu Cys Val Cys Ala 
            340                 345                 350         


Glu Gly Phe Ala Pro Ile Pro His Glu Pro His Arg Cys Gln Met Phe 
        355                 360                 365             


Cys Asn Gln Thr Ala Cys Pro Ala Asp Cys Asp Pro Asn Thr Gln Ala 
    370                 375                 380                 


Ser Cys Glu Cys Pro Glu Gly Tyr Ile Leu Asp Asp Gly Phe Ile Cys 
385                 390                 395                 400 


Thr Asp Ile Asp Glu Cys Glu Asn Gly Gly Phe Cys Ser Gly Val Cys 
                405                 410                 415     


His Asn Leu Pro Gly Thr Phe Glu Cys Ile Cys Gly Pro Asp Ser Ala 
            420                 425                 430         


Leu Ala Arg His Ile Gly Thr Asp Cys Asp Ser Gly 
        435                 440                 


<210>  23
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  Boc-protected
<222>  (1)..(1)

<220>
<221>  7-amido-4-methylcoumarin
<222>  (4)..(4)

<400>  23

Leu Ser Thr Arg 
1               


