                         SEQUENCE LISTING



<110>  Technion Research & Development Foundation Ltd.

       Reiter, Yoram

       OREN, Ravit

       COHEN, Maya

 

<120>  CHIMERIC ANTIGEN RECEPTORS AND METHODS OF THEIR USE



<130>  62493



<150>  US 61/406,609

<151>  2010-10-26



<160>  474   



<170>  PatentIn version 3.5



<210>  1

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Amino acid sequence encoding WT1Db126 peptide



<400>  1



Arg Met Phe Pro Asn Ala Pro Tyr Leu 

1               5                   





<210>  2

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Amino acid sequence encoding (Gly4Ser)3 linker peptide



<400>  2



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 

1               5                   10                  15  





<210>  3

<211>  249

<212>  PRT

<213>  Homo sapiens



<400>  3



Met Gly Ser Asp Val Arg Asp Leu Asn Ala Leu Leu Pro Ala Val Pro 

1               5                   10                  15      





Ser Leu Gly Gly Gly Gly Gly Cys Ala Leu Pro Val Ser Gly Ala Ala 

            20                  25                  30          





Gln Trp Ala Pro Val Leu Asp Phe Ala Pro Pro Gly Ala Ser Ala Tyr 

        35                  40                  45              





Gly Ser Leu Gly Gly Pro Ala Pro Pro Pro Ala Pro Pro Pro Pro Pro 

    50                  55                  60                  





Pro Pro Pro Pro His Ser Phe Ile Lys Gln Glu Pro Ser Trp Gly Gly 

65                  70                  75                  80  





Ala Glu Pro His Glu Glu Gln Cys Leu Ser Ala Phe Thr Val His Phe 

                85                  90                  95      





Ser Gly Gln Phe Thr Gly Thr Ala Gly Ala Cys Arg Tyr Gly Pro Phe 

            100                 105                 110         





Gly Pro Pro Pro Pro Ser Gln Ala Ser Ser Gly Gln Ala Arg Met Phe 

        115                 120                 125             





Pro Asn Ala Pro Tyr Leu Pro Ser Cys Leu Glu Ser Gln Pro Ala Ile 

    130                 135                 140                 





Arg Asn Gln Gly Tyr Ser Thr Val Thr Phe Asp Gly Thr Pro Ser Tyr 

145                 150                 155                 160 





Gly His Thr Pro Ser His His Ala Ala Gln Phe Pro Asn His Ser Phe 

                165                 170                 175     





Lys His Glu Asp Pro Met Gly Gln Gln Gly Ser Leu Gly Glu Gln Gln 

            180                 185                 190         





Tyr Ser Val Pro Pro Pro Val Tyr Gly Cys His Thr Pro Thr Asp Ser 

        195                 200                 205             





Cys Thr Gly Ser Gln Ala Leu Leu Leu Arg Thr Pro Tyr Ser Ser Asp 

    210                 215                 220                 





Asn Leu Tyr Gln Met Thr Ser Gln Leu Glu Cys Met Thr Trp Asn Gln 

225                 230                 235                 240 





Met Asn Leu Gly Ala Thr Leu Lys Gly 

                245                 





<210>  4

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Amino acid sequence encoding GAD555-567 peptide



<400>  4



Asn Phe Phe Arg Met Val Ile Ser Asn Pro Ala Ala Thr 

1               5                   10              





<210>  5

<211>  10

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Amino acid sequence encoding GAD556-565 peptide



<400>  5



Phe Phe Arg Met Val Ile Ser Asn Pro Ala 

1               5                   10  





<210>  6

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Amino acid sequence encoding MOG-35-55 peptide



<400>  6



Met Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu 

1               5                   10                  15      





Tyr Arg Asn Gly Lys 

            20      





<210>  7

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Amino acid sequence encoding WT1 235 peptide



<400>  7



Cys Met Thr Trp Asn Gln Met Asn Leu 

1               5                   





<210>  8

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Amino acid sequence encoding Tyrosinase 369-377 peptide



<400>  8



Tyr Met Asp Gly Thr Met Ser Gln Val 

1               5                   





<210>  9

<211>  10

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Amino acid sequence encoding MART-1 antigenic peptide



<400>  9



Glu Ala Ala Gly Ile Gly Ile Leu Thr Val 

1               5                   10  





<210>  10

<211>  548

<212>  PRT

<213>  Human herpesvirus 5



<400>  10



Met Glu Ser Arg Gly Arg Arg Cys Pro Glu Met Ile Ser Val Leu Gly 

1               5                   10                  15      





Pro Ile Ser Gly His Val Leu Lys Ala Val Phe Ser Arg Gly Asp Thr 

            20                  25                  30          





Pro Val Leu Pro His Glu Thr Arg Leu Leu Gln Thr Gly Ile His Val 

        35                  40                  45              





Arg Val Ser Gln Pro Ser Leu Ile Leu Val Ser Gln Tyr Thr Pro Asp 

    50                  55                  60                  





Ser Thr Pro Cys His Arg Gly Asp Asn Gln Leu Gln Val Gln His Thr 

65                  70                  75                  80  





Tyr Phe Thr Gly Ser Glu Val Glu Asn Val Ser Val Asn Glu Pro Met 

                85                  90                  95      





Ser Ile Tyr Val Tyr Ala Leu Pro Leu Lys Met Leu Asn Ile Pro Ser 

            100                 105                 110         





Ile Asn Val His His Tyr Pro Ser Ala Ala Glu Arg Lys His Arg His 

        115                 120                 125             





Leu Pro Val Ala Asp Ala Val Ile His Ala Ser Gly Lys Gln Met Trp 

    130                 135                 140                 





Gln Ala Arg Leu Thr Val Ser Gly Leu Ala Trp Thr Arg Gln Gln Asn 

145                 150                 155                 160 





Gln Trp Lys Glu Pro Asp Val Tyr Tyr Thr Ser Ala Phe Val Phe Pro 

                165                 170                 175     





Thr Lys Asp Val Ala Leu Arg His Val Val Cys Ala His Glu Leu Val 

            180                 185                 190         





Cys Ser Met Glu Asn Thr Arg Ala Thr Lys Met Gln Val Ile Gly Asp 

        195                 200                 205             





Gln Tyr Val Lys Val Tyr Leu Glu Ser Phe Cys Glu Asp Val Pro Ser 

    210                 215                 220                 





Gly Lys Leu Phe Met His Val Thr Leu Gly Ser Asp Val Glu Glu Asp 

225                 230                 235                 240 





Leu Thr Met Thr Arg Asn Pro Gln Pro Phe Met Arg Pro His Glu Arg 

                245                 250                 255     





Asn Gly Phe Thr Val Leu Cys Pro Lys Asn Met Ile Ile Lys Pro Gly 

            260                 265                 270         





Lys Ile Ser His Ile Met Leu Asp Val Ala Phe Thr Ser His Glu His 

        275                 280                 285             





Phe Gly Leu Leu Cys Pro Lys Ser Ile Pro Gly Leu Ser Ile Ser Gly 

    290                 295                 300                 





Asn Leu Leu Met Asn Gly Gln Gln Ile Phe Leu Glu Val Gln Ala Ile 

305                 310                 315                 320 





Arg Glu Thr Val Glu Leu Arg Gln Tyr Asp Pro Val Ala Ala Leu Phe 

                325                 330                 335     





Phe Phe Asp Ile Asp Leu Leu Leu Gln Arg Gly Pro Gln Tyr Ser Glu 

            340                 345                 350         





His Pro Thr Phe Thr Ser Gln Tyr Arg Ile Gln Gly Lys Leu Glu Tyr 

        355                 360                 365             





Arg His Thr Trp Asp Arg His Asp Glu Gly Ala Ala Gln Gly Asp Asp 

    370                 375                 380                 





Asp Val Trp Thr Ser Gly Ser Asp Ser Asp Glu Glu Leu Val Thr Thr 

385                 390                 395                 400 





Glu Arg Lys Thr Pro Arg Val Thr Gly Gly Gly Ala Met Ala Gly Ala 

                405                 410                 415     





Ser Thr Ser Ala Gly Arg Lys Arg Lys Ser Ala Ser Ser Ala Thr Ala 

            420                 425                 430         





Cys Thr Ser Gly Val Met Thr Arg Gly Arg Leu Lys Ala Glu Ser Thr 

        435                 440                 445             





Val Ala Pro Glu Glu Asp Thr Asp Glu Asp Ser Asp Asn Glu Ile His 

    450                 455                 460                 





Asn Pro Ala Val Phe Thr Trp Pro Pro Trp Gln Ala Gly Ile Leu Ala 

465                 470                 475                 480 





Arg Asn Leu Val Pro Met Val Ala Thr Val Gln Gly Gln Asn Leu Lys 

                485                 490                 495     





Tyr Gln Glu Phe Phe Trp Asp Ala Asn Asp Ile Tyr Arg Ile Phe Ala 

            500                 505                 510         





Glu Leu Glu Gly Val Trp Gln Pro Ala Ala Gln Pro Lys Arg Arg Arg 

        515                 520                 525             





His Arg Gln Asp Ala Leu Pro Gly Pro Cys Ile Ala Ser Thr Pro Lys 

    530                 535                 540                 





Lys His Arg Gly 

545             





<210>  11

<211>  561

<212>  PRT

<213>  Human herpesvirus 5



<400>  11



Met Glu Ser Arg Gly Arg Arg Cys Pro Glu Met Ile Ser Val Leu Gly 

1               5                   10                  15      





Pro Ile Ser Gly His Val Leu Lys Ala Val Phe Ser Arg Gly Asp Thr 

            20                  25                  30          





Pro Val Leu Pro His Glu Thr Arg Leu Leu Gln Thr Gly Ile His Val 

        35                  40                  45              





Arg Val Ser Gln Pro Ser Leu Ile Leu Val Ser Gln Tyr Thr Pro Asp 

    50                  55                  60                  





Ser Thr Pro Cys His Arg Gly Asp Asn Gln Leu Gln Val Gln His Thr 

65                  70                  75                  80  





Tyr Phe Thr Gly Ser Glu Val Glu Asn Val Ser Val Asn Val His Asn 

                85                  90                  95      





Pro Thr Gly Arg Ser Ile Cys Pro Ser Gln Glu Pro Met Ser Ile Tyr 

            100                 105                 110         





Val Tyr Ala Leu Pro Leu Lys Met Leu Asn Ile Pro Ser Ile Asn Val 

        115                 120                 125             





His His Tyr Pro Ser Ala Ala Glu Arg Lys His Arg His Leu Pro Val 

    130                 135                 140                 





Ala Asp Ala Val Ile His Ala Ser Gly Lys Gln Met Trp Gln Ala Arg 

145                 150                 155                 160 





Leu Thr Val Ser Gly Leu Ala Trp Thr Arg Gln Gln Asn Gln Trp Lys 

                165                 170                 175     





Glu Pro Asp Val Tyr Tyr Thr Ser Ala Phe Val Phe Pro Thr Lys Asp 

            180                 185                 190         





Val Ala Leu Arg His Val Val Cys Ala His Glu Leu Val Cys Ser Met 

        195                 200                 205             





Glu Asn Thr Arg Ala Thr Lys Met Gln Val Ile Gly Asp Gln Tyr Val 

    210                 215                 220                 





Lys Val Tyr Leu Glu Ser Phe Cys Glu Asp Val Pro Ser Gly Lys Leu 

225                 230                 235                 240 





Phe Met His Val Thr Leu Gly Ser Asp Val Glu Glu Asp Leu Thr Met 

                245                 250                 255     





Thr Arg Asn Pro Gln Pro Phe Met Arg Pro His Glu Arg Asn Gly Phe 

            260                 265                 270         





Thr Val Leu Cys Pro Lys Asn Met Ile Ile Lys Pro Gly Lys Ile Ser 

        275                 280                 285             





His Ile Met Leu Asp Val Ala Phe Thr Ser His Glu His Phe Gly Leu 

    290                 295                 300                 





Leu Cys Pro Lys Ser Ile Pro Gly Leu Ser Ile Ser Gly Asn Leu Leu 

305                 310                 315                 320 





Met Asn Gly Gln Gln Ile Phe Leu Glu Val Gln Ala Ile Arg Glu Thr 

                325                 330                 335     





Val Glu Leu Arg Gln Tyr Asp Pro Val Ala Ala Leu Phe Phe Phe Asp 

            340                 345                 350         





Ile Asp Leu Leu Leu Gln Arg Gly Pro Gln Tyr Ser Glu His Pro Thr 

        355                 360                 365             





Phe Thr Ser Gln Tyr Arg Ile Gln Gly Lys Leu Glu Tyr Arg His Thr 

    370                 375                 380                 





Trp Asp Arg His Asp Glu Gly Ala Ala Gln Gly Asp Asp Asp Val Trp 

385                 390                 395                 400 





Thr Ser Gly Ser Asp Ser Asp Glu Glu Leu Val Thr Thr Glu Arg Lys 

                405                 410                 415     





Thr Pro Arg Val Thr Gly Gly Gly Ala Met Ala Gly Ala Ser Thr Ser 

            420                 425                 430         





Ala Gly Arg Lys Arg Lys Ser Ala Ser Ser Ala Thr Ala Cys Thr Ser 

        435                 440                 445             





Gly Val Met Thr Arg Gly Arg Leu Lys Ala Glu Ser Thr Val Ala Pro 

    450                 455                 460                 





Glu Glu Asp Thr Asp Glu Asp Ser Asp Asn Glu Ile His Asn Pro Ala 

465                 470                 475                 480 





Val Phe Thr Trp Pro Pro Trp Gln Ala Gly Ile Leu Ala Arg Asn Leu 

                485                 490                 495     





Val Pro Met Val Ala Thr Val Gln Gly Gln Asn Leu Lys Tyr Gln Glu 

            500                 505                 510         





Phe Phe Trp Asp Ala Asn Asp Ile Tyr Arg Ile Phe Ala Glu Leu Glu 

        515                 520                 525             





Gly Val Trp Gln Pro Ala Ala Gln Pro Lys Arg Arg Arg His Arg Gln 

    530                 535                 540                 





Asp Ala Leu Pro Gly Pro Cys Ile Ala Ser Thr Pro Lys Lys His Arg 

545                 550                 555                 560 





Gly 

    





<210>  12

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Amino acid sequence encoding gp100: G2-209-2M peptide



<400>  12



Ile Met Asp Gln Val Pro Phe Ser Val 

1               5                   





<210>  13

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Amino acid sequence encoding gp100-280 peptide



<400>  13



Tyr Leu Glu Pro Gly Pro Val Thr Ala 

1               5                   





<210>  14

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Amino acid sequence encoding HIV Gag peptide



<400>  14



Ser Leu Tyr Asn Tyr Val Ala Thr Leu 

1               5                   





<210>  15

<211>  8

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Amino acid sequence encoding MDM2



<400>  15



Leu Leu Gly Asp Leu Phe Gly Val 

1               5               





<210>  16

<211>  114

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Amino acid sequence encoding VL of F2 CAR



<400>  16



Leu Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly 

1               5                   10                  15      





Lys Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser 

            20                  25                  30          





Asn Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr 

        35                  40                  45              





Val Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 

    50                  55                  60                  





Ser Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser 

65                  70                  75                  80  





Gly Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp 

                85                  90                  95      





Ser Ser Asn Gln Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val 

            100                 105                 110         





Leu Ser 

        





<210>  17

<211>  117

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Amino acid sequence encoding VH of F2 CAR



<400>  17



Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 

1               5                   10                  15      





Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 

            20                  25                  30          





Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 

        35                  40                  45              





Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 

    50                  55                  60                  





Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 

65                  70                  75                  80  





Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 

                85                  90                  95      





Ala Arg Gly Asp Tyr Tyr Gly Leu Thr Phe Asp Pro Trp Gly Gln Gly 

            100                 105                 110         





Thr Leu Val Thr Val 

        115         





<210>  18

<211>  342

<212>  PRT

<213>  Artificial sequence



<220>

<223>  polynucleotide encoding VL of F2 CAR



<400>  18



Cys Thr Gly Ala Ala Cys Thr Thr Cys Ala Thr Gly Cys Thr Gly Ala 

1               5                   10                  15      





Cys Cys Cys Ala Gly Cys Cys Cys Cys Ala Cys Ala Gly Cys Gly Thr 

            20                  25                  30          





Gly Thr Cys Cys Gly Ala Gly Ala Gly Cys Cys Cys Cys Gly Gly Cys 

        35                  40                  45              





Ala Ala Gly Ala Cys Cys Gly Thr Gly Ala Cys Cys Ala Thr Cys Ala 

    50                  55                  60                  





Gly Cys Thr Gly Cys Ala Cys Cys Ala Gly Ala Ala Gly Cys Ala Gly 

65                  70                  75                  80  





Cys Gly Gly Cys Ala Gly Cys Ala Thr Thr Gly Cys Cys Ala Gly Cys 

                85                  90                  95      





Ala Ala Cys Thr Ala Cys Gly Thr Gly Cys Ala Gly Thr Gly Gly Thr 

            100                 105                 110         





Ala Thr Cys Ala Gly Cys Ala Gly Ala Gly Gly Cys Cys Cys Gly Gly 

        115                 120                 125             





Cys Ala Gly Cys Ala Gly Cys Cys Cys Cys Ala Cys Cys Ala Cys Cys 

    130                 135                 140                 





Gly Thr Gly Ala Thr Cys Thr Ala Cys Gly Ala Gly Gly Ala Cys Ala 

145                 150                 155                 160 





Ala Cys Cys Ala Gly Cys Gly Gly Cys Cys Cys Ala Gly Cys Gly Gly 

                165                 170                 175     





Cys Gly Thr Gly Cys Cys Cys Gly Ala Cys Cys Gly Gly Thr Thr Cys 

            180                 185                 190         





Ala Gly Cys Gly Gly Cys Thr Cys Cys Ala Thr Cys Gly Ala Cys Ala 

        195                 200                 205             





Gly Cys Ala Gly Cys Thr Cys Cys Ala Ala Cys Ala Gly Cys Gly Cys 

    210                 215                 220                 





Cys Ala Gly Cys Cys Thr Gly Ala Cys Cys Ala Thr Cys Thr Cys Cys 

225                 230                 235                 240 





Gly Gly Cys Cys Thr Gly Ala Ala Ala Ala Cys Cys Gly Ala Gly Gly 

                245                 250                 255     





Ala Cys Gly Ala Gly Gly Cys Cys Gly Ala Cys Thr Ala Thr Thr Ala 

            260                 265                 270         





Cys Thr Gly Cys Cys Ala Gly Thr Cys Thr Thr Ala Cys Gly Ala Cys 

        275                 280                 285             





Ala Gly Cys Ala Gly Cys Ala Ala Cys Cys Ala Gly Ala Ala Cys Thr 

    290                 295                 300                 





Gly Gly Gly Thr Gly Thr Thr Cys Gly Gly Cys Gly Gly Ala Gly Gly 

305                 310                 315                 320 





Thr Ala Cys Ala Ala Ala Gly Cys Thr Gly Ala Cys Cys Gly Thr Gly 

                325                 330                 335     





Cys Thr Gly Thr Cys Gly 

            340         





<210>  19

<211>  351

<212>  PRT

<213>  Artificial sequence



<220>

<223>  polynucleotide encoding VH of F2 CAR



<400>  19



Cys Ala Gly Gly Thr Gly Cys Ala Gly Cys Thr Gly Gly Thr Gly Cys 

1               5                   10                  15      





Ala Gly Thr Cys Thr Gly Gly Cys Gly Gly Cys Gly Gly Ala Cys Thr 

            20                  25                  30          





Gly Gly Thr Cys Ala Ala Gly Cys Cys Thr Gly Gly Cys Gly Gly Cys 

        35                  40                  45              





Ala Gly Cys Cys Thr Gly Ala Gly Ala Cys Thr Gly Ala Gly Cys Thr 

    50                  55                  60                  





Gly Cys Gly Cys Cys Gly Cys Cys Ala Gly Cys Gly Gly Cys Thr Thr 

65                  70                  75                  80  





Cys Ala Cys Cys Thr Thr Cys Ala Gly Cys Ala Gly Cys Thr Ala Cys 

                85                  90                  95      





Ala Gly Cys Ala Thr Gly Ala Ala Cys Thr Gly Gly Gly Thr Cys Cys 

            100                 105                 110         





Gly Cys Cys Ala Gly Gly Cys Thr Cys Cys Thr Gly Gly Cys Ala Ala 

        115                 120                 125             





Gly Gly Gly Cys Cys Thr Gly Gly Ala Ala Thr Gly Gly Gly Thr Gly 

    130                 135                 140                 





Thr Cys Cys Ala Gly Cys Ala Thr Cys Ala Gly Cys Ala Gly Cys Ala 

145                 150                 155                 160 





Gly Cys Ala Gly Cys Thr Cys Cys Thr Ala Cys Ala Thr Cys Thr Ala 

                165                 170                 175     





Cys Thr Ala Cys Gly Cys Cys Gly Ala Cys Ala Gly Cys Gly Thr Gly 

            180                 185                 190         





Ala Ala Gly Gly Gly Cys Cys Gly Gly Thr Thr Cys Ala Cys Cys Ala 

        195                 200                 205             





Thr Cys Ala Gly Cys Cys Gly Gly Gly Ala Cys Ala Ala Cys Gly Cys 

    210                 215                 220                 





Cys Ala Ala Gly Ala Ala Cys Ala Gly Cys Cys Thr Gly Thr Ala Cys 

225                 230                 235                 240 





Cys Thr Gly Cys Ala Gly Ala Thr Gly Ala Ala Cys Ala Gly Cys Cys 

                245                 250                 255     





Thr Gly Cys Gly Gly Gly Cys Cys Gly Ala Gly Gly Ala Cys Ala Cys 

            260                 265                 270         





Cys Gly Cys Cys Gly Thr Gly Thr Ala Cys Thr Ala Cys Thr Gly Cys 

        275                 280                 285             





Gly Cys Cys Ala Gly Gly Gly Gly Cys Gly Ala Cys Thr Ala Cys Thr 

    290                 295                 300                 





Ala Cys Gly Gly Cys Cys Thr Gly Ala Cys Cys Thr Thr Cys Gly Ala 

305                 310                 315                 320 





Cys Cys Cys Cys Thr Gly Gly Gly Gly Ala Cys Ala Gly Gly Gly Cys 

                325                 330                 335     





Ala Cys Cys Cys Thr Gly Gly Thr Cys Ala Cys Cys Gly Thr Gly 

            340                 345                 350     





<210>  20

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Amino acid sequence encoding leader in CAR



<400>  20



Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 

1               5                   10                  15      





Val Ile Met Ser Arg 

            20      





<210>  21

<211>  63

<212>  PRT

<213>  Artificial sequence



<220>

<223>  polynucleotide encoding leader in CAR



<400>  21



Ala Thr Gly Gly Ala Thr Thr Thr Thr Cys Ala Gly Gly Thr Gly Cys 

1               5                   10                  15      





Ala Gly Ala Thr Thr Thr Thr Cys Ala Gly Cys Thr Thr Cys Cys Thr 

            20                  25                  30          





Gly Cys Thr Ala Ala Thr Cys Ala Gly Thr Gly Cys Cys Thr Cys Ala 

        35                  40                  45              





Gly Thr Cys Ala Thr Ala Ala Thr Gly Thr Cys Thr Ala Gly Ala 

    50                  55                  60              





<210>  22

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Amino acid sequence encoding MBP-85-99



<400>  22



Met Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg 

1               5                   10                  15      





<210>  23

<211>  45

<212>  PRT

<213>  Artificial sequence



<220>

<223>  polynucleotide encoding linker between VL and VH in CAR



<400>  23



Gly Gly Cys Gly Gly Ala Gly Gly Gly Gly Gly Cys Thr Cys Thr Gly 

1               5                   10                  15      





Gly Cys Gly Gly Gly Gly Gly Ala Gly Gly Ala Thr Cys Thr Gly Gly 

            20                  25                  30          





Gly Gly Gly Cys Gly Gly Ala Gly Gly Ala Ala Gly Cys 

        35                  40                  45  





<210>  24

<211>  87

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Amino acid sequence encoding CD28 in  CAR



<400>  24



Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 

1               5                   10                  15      





Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 

            20                  25                  30          





Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 

        35                  40                  45              





Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 

    50                  55                  60                  





Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 

65                  70                  75                  80  





Ala Ala Tyr Arg Ser Gln Val 

                85          





<210>  25

<211>  261

<212>  PRT

<213>  Artificial sequence



<220>

<223>  polynucleotide encoding CD28 in  CAR



<400>  25



Ala Ala Ala Gly Gly Gly Ala Ala Ala Cys Ala Cys Cys Thr Thr Thr 

1               5                   10                  15      





Gly Thr Cys Cys Ala Ala Gly Thr Cys Cys Cys Cys Thr Ala Thr Thr 

            20                  25                  30          





Thr Cys Cys Cys Gly Gly Ala Cys Cys Thr Thr Cys Thr Ala Ala Gly 

        35                  40                  45              





Cys Cys Cys Thr Thr Thr Thr Gly Gly Gly Thr Gly Cys Thr Gly Gly 

    50                  55                  60                  





Thr Gly Gly Thr Gly Gly Thr Thr Gly Gly Thr Gly Gly Ala Gly Thr 

65                  70                  75                  80  





Cys Cys Thr Gly Gly Cys Thr Thr Gly Cys Thr Ala Thr Ala Gly Cys 

                85                  90                  95      





Thr Thr Gly Cys Thr Ala Gly Thr Ala Ala Cys Ala Gly Thr Gly Gly 

            100                 105                 110         





Cys Cys Thr Thr Thr Ala Thr Thr Ala Thr Thr Thr Thr Cys Thr Gly 

        115                 120                 125             





Gly Gly Thr Gly Ala Gly Gly Ala Gly Thr Ala Ala Gly Ala Gly Gly 

    130                 135                 140                 





Ala Gly Cys Ala Gly Gly Cys Thr Cys Cys Thr Gly Cys Ala Cys Ala 

145                 150                 155                 160 





Gly Thr Gly Ala Cys Thr Ala Cys Ala Thr Gly Ala Ala Cys Ala Thr 

                165                 170                 175     





Gly Ala Cys Thr Cys Cys Cys Cys Gly Cys Cys Gly Cys Cys Cys Cys 

            180                 185                 190         





Gly Gly Gly Cys Cys Cys Ala Cys Cys Cys Gly Cys Ala Ala Gly Cys 

        195                 200                 205             





Ala Thr Thr Ala Cys Cys Ala Gly Cys Cys Cys Thr Ala Thr Gly Cys 

    210                 215                 220                 





Cys Cys Cys Ala Cys Cys Ala Cys Gly Cys Gly Ala Cys Thr Thr Cys 

225                 230                 235                 240 





Gly Cys Ala Gly Cys Cys Thr Ala Thr Ala Gly Ala Thr Cys Thr Cys 

                245                 250                 255     





Ala Ala Gly Thr Gly 

            260     





<210>  26

<211>  24

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Amino acid sequence encoding Gamma in CAR



<400>  26



Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val Tyr Thr 

1               5                   10                  15      





Gly Leu Ser Thr Arg Asn Gln Glu 

            20                  





<210>  27

<211>  72

<212>  PRT

<213>  Artificial sequence



<220>

<223>  polynucleotide encoding Gamma in  CAR



<400>  27



Cys Gly Ala Ala Ala Gly Gly Cys Ala Gly Cys Thr Ala Thr Ala Ala 

1               5                   10                  15      





Cys Cys Ala Gly Cys Thr Ala Thr Gly Ala Gly Ala Ala Ala Thr Cys 

            20                  25                  30          





Ala Gly Ala Thr Gly Gly Thr Gly Thr Thr Thr Ala Cys Ala Cys Gly 

        35                  40                  45              





Gly Gly Cys Cys Thr Gly Ala Gly Cys Ala Cys Cys Ala Gly Gly Ala 

    50                  55                  60                  





Ala Cys Cys Ala Gly Gly Ala Gly 

65                  70          





<210>  28

<211>  110

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Amino acid sequence encoding VL of F3 CAR



<400>  28



Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu 

1               5                   10                  15      





Gly Gln Thr Val Lys Ile Thr Cys Gln Gly Asp Ser Leu Arg Ile His 

            20                  25                  30          





Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val 

        35                  40                  45              





Ile Tyr Gly Lys Asp Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 

    50                  55                  60                  





Gly Ser Ser Ser Gly Thr Ser Ala Ser Leu Thr Ile Thr Gly Ala Arg 

65                  70                  75                  80  





Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Asn Ser Gly 

                85                  90                  95      





Asp His Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Val 

            100                 105                 110 





<210>  29

<211>  115

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Amino acid sequence encoding VH of F3 CAR



<400>  29



Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Thr Gly Ser 

1               5                   10                  15      





Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Tyr Arg 

            20                  25                  30          





Tyr Leu His Trp Ala Arg Gln Ala Pro Gly Gln Ala Leu Glu Trp Met 

        35                  40                  45              





Gly Trp Ile Thr Pro Phe Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 

    50                  55                  60                  





Gln Asp Arg Val Thr Ile Thr Arg Asp Arg Ser Met Ser Thr Ala Tyr 

65                  70                  75                  80  





Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 

                85                  90                  95      





Ala Ser Ser Ala Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met 

            100                 105                 110         





Val Thr Val 

        115 





<210>  30

<211>  330

<212>  PRT

<213>  Artificial sequence



<220>

<223>  polynucleotide encoding VL of F3 CAR



<400>  30



Gly Cys Ala Cys Thr Thr Thr Cys Thr Thr Cys Thr Gly Ala Gly Cys 

1               5                   10                  15      





Thr Gly Ala Cys Thr Cys Ala Gly Gly Ala Cys Cys Cys Thr Gly Cys 

            20                  25                  30          





Thr Gly Thr Gly Thr Cys Thr Gly Thr Gly Gly Cys Cys Thr Thr Gly 

        35                  40                  45              





Gly Gly Ala Cys Ala Gly Ala Cys Ala Gly Thr Cys Ala Ala Gly Ala 

    50                  55                  60                  





Thr Cys Ala Cys Ala Thr Gly Cys Cys Ala Ala Gly Gly Ala Gly Ala 

65                  70                  75                  80  





Cys Ala Gly Cys Cys Thr Cys Ala Gly Gly Ala Thr Cys Cys Ala Thr 

                85                  90                  95      





Thr Ala Thr Gly Cys Ala Ala Gly Cys Thr Gly Gly Thr Ala Cys Cys 

            100                 105                 110         





Ala Ala Cys Ala Gly Ala Ala Gly Cys Cys Ala Gly Gly Ala Cys Ala 

        115                 120                 125             





Gly Gly Cys Cys Cys Cys Thr Gly Thr Cys Cys Thr Thr Gly Thr Cys 

    130                 135                 140                 





Ala Thr Cys Thr Ala Thr Gly Gly Thr Ala Ala Ala Gly Ala Cys Ala 

145                 150                 155                 160 





Ala Cys Cys Gly Gly Cys Cys Cys Thr Cys Ala Gly Gly Ala Ala Thr 

                165                 170                 175     





Cys Cys Cys Cys Gly Ala Cys Cys Gly Ala Thr Thr Cys Thr Cys Thr 

            180                 185                 190         





Gly Gly Cys Thr Cys Cys Ala Gly Cys Thr Cys Ala Gly Gly Ala Ala 

        195                 200                 205             





Cys Cys Thr Cys Cys Gly Cys Thr Thr Cys Cys Cys Thr Gly Ala Cys 

    210                 215                 220                 





Thr Ala Thr Cys Ala Cys Thr Gly Gly Gly Gly Cys Thr Cys Gly Gly 

225                 230                 235                 240 





Gly Cys Gly Gly Ala Gly Gly Ala Thr Gly Ala Gly Gly Cys Thr Gly 

                245                 250                 255     





Ala Cys Thr Ala Thr Thr Ala Cys Thr Gly Thr Ala Ala Cys Thr Cys 

            260                 265                 270         





Cys Cys Gly Gly Gly Ala Cys Ala Ala Thr Ala Gly Thr Gly Gly Thr 

        275                 280                 285             





Gly Ala Thr Cys Ala Thr Gly Thr Gly Cys Thr Cys Thr Thr Cys Gly 

    290                 295                 300                 





Gly Cys Gly Gly Ala Gly Gly Gly Ala Cys Cys Ala Ala Gly Thr Thr 

305                 310                 315                 320 





Gly Ala Cys Cys Gly Thr Cys Gly Thr Gly 

                325                 330 





<210>  31

<211>  345

<212>  PRT

<213>  Artificial sequence



<220>

<223>  polynucleotide encoding VH of F3 CAR



<400>  31



Gly Ala Gly Gly Thr Gly Cys Ala Gly Cys Thr Gly Gly Thr Gly Cys 

1               5                   10                  15      





Ala Gly Thr Cys Thr Gly Gly Gly Gly Cys Thr Gly Ala Gly Gly Thr 

            20                  25                  30          





Gly Ala Ala Gly Ala Ala Gly Ala Cys Thr Gly Gly Gly Thr Cys Cys 

        35                  40                  45              





Thr Cys Ala Gly Thr Gly Ala Ala Gly Gly Thr Thr Thr Cys Cys Thr 

    50                  55                  60                  





Gly Cys Ala Ala Gly Gly Cys Thr Thr Cys Cys Gly Gly Ala Thr Ala 

65                  70                  75                  80  





Cys Ala Cys Cys Thr Thr Cys Ala Cys Cys Thr Ala Cys Cys Gly Cys 

                85                  90                  95      





Thr Ala Cys Cys Thr Gly Cys Ala Cys Thr Gly Gly Gly Cys Gly Cys 

            100                 105                 110         





Gly Ala Cys Ala Gly Gly Cys Cys Cys Cys Cys Gly Gly Ala Cys Ala 

        115                 120                 125             





Ala Gly Cys Gly Cys Thr Thr Gly Ala Gly Thr Gly Gly Ala Thr Gly 

    130                 135                 140                 





Gly Gly Ala Thr Gly Gly Ala Thr Cys Ala Cys Ala Cys Cys Thr Thr 

145                 150                 155                 160 





Thr Cys Ala Ala Thr Gly Gly Thr Ala Ala Cys Ala Cys Cys Ala Ala 

                165                 170                 175     





Cys Thr Ala Cys Gly Cys Ala Cys Ala Gly Ala Ala Ala Thr Thr Cys 

            180                 185                 190         





Cys Ala Gly Gly Ala Cys Ala Gly Ala Gly Thr Cys Ala Cys Cys Ala 

        195                 200                 205             





Thr Thr Ala Cys Cys Ala Gly Gly Gly Ala Cys Ala Gly Gly Thr Cys 

    210                 215                 220                 





Thr Ala Thr Gly Ala Gly Cys Ala Cys Ala Gly Cys Cys Thr Ala Cys 

225                 230                 235                 240 





Ala Thr Gly Gly Ala Gly Cys Thr Gly Ala Gly Cys Ala Gly Cys Cys 

                245                 250                 255     





Thr Gly Ala Gly Ala Thr Cys Thr Gly Ala Gly Gly Ala Cys Ala Cys 

            260                 265                 270         





Ala Gly Cys Cys Ala Thr Gly Thr Ala Thr Thr Ala Cys Thr Gly Thr 

        275                 280                 285             





Gly Cys Ala Ala Gly Cys Thr Cys Ala Gly Cys Cys Thr Ala Thr Gly 

    290                 295                 300                 





Ala Thr Gly Cys Thr Thr Thr Thr Gly Ala Thr Ala Thr Cys Thr Gly 

305                 310                 315                 320 





Gly Gly Gly Cys Cys Ala Ala Gly Gly Gly Ala Cys Ala Ala Thr Gly 

                325                 330                 335     





Gly Thr Cys Ala Cys Cys Gly Thr Gly 

            340                 345 





<210>  32

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Amino acid sequence encoding GAD autoantigenic peptide



<400>  32



Asn Phe Phe Arg Met Val Ile Ser Asn Pro Ala Ala Thr 

1               5                   10              





<210>  33

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Amino acid sequence encoding a short peptide



<400>  33



Asn Phe Phe Arg Met Val Ile Ser Asn Pro Ala Ala Thr 

1               5                   10              





<210>  34

<211>  135

<212>  PRT

<213>  Artificial sequence



<220>

<223>  polynucleotide encoding CD8a hinge domain



<400>  34



Ala Cys Cys Ala Cys Gly Ala Cys Gly Cys Cys Ala Gly Cys Gly Cys 

1               5                   10                  15      





Cys Gly Cys Gly Ala Cys Cys Ala Cys Cys Ala Ala Cys Ala Cys Cys 

            20                  25                  30          





Gly Gly Cys Gly Cys Cys Cys Ala Cys Cys Ala Thr Cys Gly Cys Gly 

        35                  40                  45              





Thr Cys Gly Cys Ala Gly Cys Cys Cys Cys Thr Gly Thr Cys Cys Cys 

    50                  55                  60                  





Thr Gly Cys Gly Cys Cys Cys Ala Gly Ala Gly Gly Cys Gly Thr Gly 

65                  70                  75                  80  





Cys Cys Gly Gly Cys Cys Ala Gly Cys Gly Gly Cys Gly Gly Gly Gly 

                85                  90                  95      





Gly Gly Cys Gly Cys Ala Gly Thr Gly Cys Ala Cys Ala Cys Gly Ala 

            100                 105                 110         





Gly Gly Gly Gly Gly Cys Thr Gly Gly Ala Cys Thr Thr Cys Gly Cys 

        115                 120                 125             





Cys Thr Gly Thr Gly Ala Thr 

    130                 135 





<210>  35

<211>  47

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Amino acid sequence encoding CD8a hinge domain



<400>  35



Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 

1               5                   10                  15      





Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 

            20                  25                  30          





Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 

        35                  40                  45          





<210>  36

<211>  110

<212>  PRT

<213>  Homo sapiens



<400>  36



Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 

1               5                   10                  15      





Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly 

            20                  25                  30          





Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 

        35                  40                  45              





Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly 

    50                  55                  60                  





Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu 

65                  70                  75                  80  





Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys 

                85                  90                  95      





Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 

            100                 105                 110 





<210>  37

<211>  86

<212>  PRT

<213>  Homo sapiens



<400>  37



Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 

1               5                   10                  15      





Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 

            20                  25                  30          





Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro 

        35                  40                  45              





Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys 

    50                  55                  60                  





Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 

65                  70                  75                  80  





Leu Glu Asn Tyr Cys Asn 

                85      





<210>  38

<211>  585

<212>  PRT

<213>  Homo sapiens



<400>  38



Met Ala Ser Pro Gly Ser Gly Phe Trp Ser Phe Gly Ser Glu Asp Gly 

1               5                   10                  15      





Ser Gly Asp Ser Glu Asn Pro Gly Thr Ala Arg Ala Trp Cys Gln Val 

            20                  25                  30          





Ala Gln Lys Phe Thr Gly Gly Ile Gly Asn Lys Leu Cys Ala Leu Leu 

        35                  40                  45              





Tyr Gly Asp Ala Glu Lys Pro Ala Glu Ser Gly Gly Ser Gln Pro Pro 

    50                  55                  60                  





Arg Ala Ala Ala Arg Lys Ala Ala Cys Ala Cys Asp Gln Lys Pro Cys 

65                  70                  75                  80  





Ser Cys Ser Lys Val Asp Val Asn Tyr Ala Phe Leu His Ala Thr Asp 

                85                  90                  95      





Leu Leu Pro Ala Cys Asp Gly Glu Arg Pro Thr Leu Ala Phe Leu Gln 

            100                 105                 110         





Asp Val Met Asn Ile Leu Leu Gln Tyr Val Val Lys Ser Phe Asp Arg 

        115                 120                 125             





Ser Thr Lys Val Ile Asp Phe His Tyr Pro Asn Glu Leu Leu Gln Glu 

    130                 135                 140                 





Tyr Asn Trp Glu Leu Ala Asp Gln Pro Gln Asn Leu Glu Glu Ile Leu 

145                 150                 155                 160 





Met His Cys Gln Thr Thr Leu Lys Tyr Ala Ile Lys Thr Gly His Pro 

                165                 170                 175     





Arg Tyr Phe Asn Gln Leu Ser Thr Gly Leu Asp Met Val Gly Leu Ala 

            180                 185                 190         





Ala Asp Trp Leu Thr Ser Thr Ala Asn Thr Asn Met Phe Thr Tyr Glu 

        195                 200                 205             





Ile Ala Pro Val Phe Val Leu Leu Glu Tyr Val Thr Leu Lys Lys Met 

    210                 215                 220                 





Arg Glu Ile Ile Gly Trp Pro Gly Gly Ser Gly Asp Gly Ile Phe Ser 

225                 230                 235                 240 





Pro Gly Gly Ala Ile Ser Asn Met Tyr Ala Met Met Ile Ala Arg Phe 

                245                 250                 255     





Lys Met Phe Pro Glu Val Lys Glu Lys Gly Met Ala Ala Leu Pro Arg 

            260                 265                 270         





Leu Ile Ala Phe Thr Ser Glu His Ser His Phe Ser Leu Lys Lys Gly 

        275                 280                 285             





Ala Ala Ala Leu Gly Ile Gly Thr Asp Ser Val Ile Leu Ile Lys Cys 

    290                 295                 300                 





Asp Glu Arg Gly Lys Met Ile Pro Ser Asp Leu Glu Arg Arg Ile Leu 

305                 310                 315                 320 





Glu Ala Lys Gln Lys Gly Phe Val Pro Phe Leu Val Ser Ala Thr Ala 

                325                 330                 335     





Gly Thr Thr Val Tyr Gly Ala Phe Asp Pro Leu Leu Ala Val Ala Asp 

            340                 345                 350         





Ile Cys Lys Lys Tyr Lys Ile Trp Met His Val Asp Ala Ala Trp Gly 

        355                 360                 365             





Gly Gly Leu Leu Met Ser Arg Lys His Lys Trp Lys Leu Ser Gly Val 

    370                 375                 380                 





Glu Arg Ala Asn Ser Val Thr Trp Asn Pro His Lys Met Met Gly Val 

385                 390                 395                 400 





Pro Leu Gln Cys Ser Ala Leu Leu Val Arg Glu Glu Gly Leu Met Gln 

                405                 410                 415     





Asn Cys Asn Gln Met His Ala Ser Tyr Leu Phe Gln Gln Asp Lys His 

            420                 425                 430         





Tyr Asp Leu Ser Tyr Asp Thr Gly Asp Lys Ala Leu Gln Cys Gly Arg 

        435                 440                 445             





His Val Asp Val Phe Lys Leu Trp Leu Met Trp Arg Ala Lys Gly Thr 

    450                 455                 460                 





Thr Gly Phe Glu Ala His Val Asp Lys Cys Leu Glu Leu Ala Glu Tyr 

465                 470                 475                 480 





Leu Tyr Asn Ile Ile Lys Asn Arg Glu Gly Tyr Glu Met Val Phe Asp 

                485                 490                 495     





Gly Lys Pro Gln His Thr Asn Val Cys Phe Trp Tyr Ile Pro Pro Ser 

            500                 505                 510         





Leu Arg Thr Leu Glu Asp Asn Glu Glu Arg Met Ser Arg Leu Ser Lys 

        515                 520                 525             





Val Ala Pro Val Ile Lys Ala Arg Met Met Glu Tyr Gly Thr Thr Met 

    530                 535                 540                 





Val Ser Tyr Gln Pro Leu Gly Asp Lys Val Asn Phe Phe Arg Met Val 

545                 550                 555                 560 





Ile Ser Asn Pro Ala Ala Thr His Gln Asp Ile Asp Phe Leu Ile Glu 

                565                 570                 575     





Glu Ile Glu Arg Leu Gly Gln Asp Leu 

            580                 585 





<210>  39

<211>  566

<212>  PRT

<213>  Homo sapiens



<400>  39



Met Pro Arg Gly Phe Leu Val Lys Arg Thr Lys Arg Thr Gly Gly Leu 

1               5                   10                  15      





Tyr Arg Val Arg Leu Ala Glu Arg Val Phe Pro Leu Leu Gly Pro Gln 

            20                  25                  30          





Gly Ala Pro Pro Phe Leu Glu Glu Ala Pro Ser Ala Ser Leu Pro Gly 

        35                  40                  45              





Ala Glu Arg Ala Thr Pro Pro Thr Arg Glu Glu Pro Gly Lys Gly Leu 

    50                  55                  60                  





Thr Ala Glu Ala Ala Arg Glu Gln Ser Gly Ser Pro Cys Arg Ala Ala 

65                  70                  75                  80  





Gly Val Ser Pro Gly Thr Gly Gly Arg Glu Gly Ala Glu Trp Arg Ala 

                85                  90                  95      





Gly Gly Arg Glu Gly Pro Gly Pro Ser Pro Ser Pro Ser Pro Ser Pro 

            100                 105                 110         





Ala Lys Pro Ala Gly Ala Glu Leu Arg Arg Ala Phe Leu Glu Arg Cys 

        115                 120                 125             





Leu Ser Ser Pro Val Ser Ala Glu Ser Phe Pro Gly Gly Ala Ala Ala 

    130                 135                 140                 





Val Ala Ala Phe Ser Cys Ser Val Ala Pro Ala Ala Ala Pro Thr Pro 

145                 150                 155                 160 





Gly Glu Gln Phe Leu Leu Pro Leu Arg Ala Pro Phe Pro Glu Pro Ala 

                165                 170                 175     





Leu Gln Pro Asp Pro Ala Pro Leu Ser Ala Ala Leu Gln Ser Leu Lys 

            180                 185                 190         





Arg Ala Ala Gly Gly Glu Arg Arg Gly Lys Ala Pro Thr Asp Cys Ala 

        195                 200                 205             





Ser Gly Pro Ala Ala Ala Gly Ile Lys Lys Pro Lys Ala Met Arg Lys 

    210                 215                 220                 





Leu Ser Phe Ala Asp Glu Val Thr Thr Ser Pro Val Leu Gly Leu Lys 

225                 230                 235                 240 





Ile Lys Glu Glu Glu Pro Gly Ala Pro Ser Arg Gly Leu Gly Gly Ser 

                245                 250                 255     





Arg Thr Pro Leu Gly Glu Phe Ile Cys Gln Leu Cys Lys Glu Gln Tyr 

            260                 265                 270         





Ala Asp Pro Phe Ala Leu Ala Gln His Arg Cys Ser Arg Ile Val Arg 

        275                 280                 285             





Val Glu Tyr Arg Cys Pro Glu Cys Asp Lys Val Phe Ser Cys Pro Ala 

    290                 295                 300                 





Asn Leu Ala Ser His Arg Arg Trp His Lys Pro Arg Pro Ala Ala Ala 

305                 310                 315                 320 





Asn Ala Ala Thr Val Ser Ser Ala Asp Gly Lys Pro Pro Ser Ser Ser 

                325                 330                 335     





Ser Ser Ser Ser Arg Asp Ser Gly Ala Ile Ala Ser Phe Leu Ala Glu 

            340                 345                 350         





Gly Lys Glu Asn Ser Arg Ile Glu Arg Thr Ala Asp Gln His Pro Gln 

        355                 360                 365             





Ala Arg Asp Ser Ser Gly Ala Asp Gln His Pro Asp Ser Ala Pro Arg 

    370                 375                 380                 





Gln Gly Leu Gln Val Leu Thr His Pro Glu Pro Pro Leu Pro Gln Gly 

385                 390                 395                 400 





Pro Tyr Thr Glu Gly Val Leu Gly Arg Arg Val Pro Val Pro Gly Ser 

                405                 410                 415     





Thr Ser Gly Gly Arg Gly Ser Glu Ile Phe Val Cys Pro Tyr Cys His 

            420                 425                 430         





Lys Lys Phe Arg Arg Gln Ala Tyr Leu Arg Lys His Leu Ser Thr His 

        435                 440                 445             





Glu Ala Gly Ser Ala Arg Ala Leu Ala Pro Gly Phe Gly Ser Glu Arg 

    450                 455                 460                 





Gly Ala Pro Leu Ala Phe Ala Cys Pro Leu Cys Gly Ala His Phe Pro 

465                 470                 475                 480 





Thr Ala Asp Ile Arg Glu Lys His Arg Leu Trp His Ala Val Arg Glu 

                485                 490                 495     





Glu Leu Leu Leu Pro Ala Leu Ala Gly Ala Pro Pro Glu Thr Ser Gly 

            500                 505                 510         





Pro Ser Gly Pro Ser Asp Gly Ser Ala Gln Gln Ile Phe Ser Cys Lys 

        515                 520                 525             





His Cys Pro Ser Thr Phe Phe Ser Ser Pro Gly Leu Thr Arg His Ile 

    530                 535                 540                 





Asn Lys Cys His Pro Ser Glu Ser Arg Gln Val Leu Leu Leu Gln Met 

545                 550                 555                 560 





Pro Leu Arg Pro Gly Cys 

                565     





<210>  40

<211>  998

<212>  PRT

<213>  Homo sapiens



<400>  40



Met Gly Pro Pro Leu Pro Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro 

1               5                   10                  15      





Pro Arg Val Leu Pro Ala Ala Pro Ser Ser Val Pro Arg Gly Arg Gln 

            20                  25                  30          





Leu Pro Gly Arg Leu Asp Gly Val Phe Gly Arg Cys Gln Lys Val Pro 

        35                  40                  45              





Ala Met Asp Phe Tyr Arg Tyr Glu Val Ser Pro Val Ala Leu Gln Arg 

    50                  55                  60                  





Leu Arg Val Ala Leu Gln Lys Leu Ser Gly Thr Gly Phe Thr Trp Gln 

65                  70                  75                  80  





Asp Asp Tyr Thr Gln Tyr Val Met Asp Gln Glu Leu Ala Asp Leu Pro 

                85                  90                  95      





Lys Thr Tyr Leu Arg Arg Pro Glu Ala Ser Ser Pro Ala Arg Pro Ser 

            100                 105                 110         





Lys His Ser Val Gly Ser Glu Arg Arg Tyr Ser Arg Glu Gly Gly Ala 

        115                 120                 125             





Ala Leu Ala Asn Ala Leu Arg Arg His Leu Pro Phe Leu Glu Ala Leu 

    130                 135                 140                 





Ser Gln Ala Pro Ala Ser Asp Val Leu Ala Arg Thr His Thr Ala Gln 

145                 150                 155                 160 





Asp Arg Pro Pro Ala Glu Gly Asp Asp Arg Phe Ser Glu Ser Ile Leu 

                165                 170                 175     





Thr Tyr Val Ala His Thr Ser Ala Leu Thr Tyr Pro Pro Gly Ser Arg 

            180                 185                 190         





Thr Gln Leu Arg Glu Asp Leu Leu Pro Arg Thr Leu Gly Gln Leu Gln 

        195                 200                 205             





Pro Asp Glu Leu Ser Pro Lys Val Asp Ser Gly Val Asp Arg His His 

    210                 215                 220                 





Leu Met Ala Ala Leu Ser Ala Tyr Ala Ala Gln Arg Pro Pro Ala Pro 

225                 230                 235                 240 





Pro Gly Glu Gly Ser Leu Glu Pro Gln Tyr Leu Leu Arg Ala Pro Ser 

                245                 250                 255     





Arg Met Pro Arg Pro Leu Leu Ala Pro Ala Ala Pro Gln Lys Trp Pro 

            260                 265                 270         





Ser Pro Leu Gly Asp Ser Glu Asp Pro Ser Ser Thr Gly Asp Gly Ala 

        275                 280                 285             





Arg Ile His Thr Leu Leu Lys Asp Leu Gln Arg Gln Pro Ala Glu Val 

    290                 295                 300                 





Arg Gly Leu Ser Gly Leu Glu Leu Asp Gly Met Ala Glu Leu Met Ala 

305                 310                 315                 320 





Gly Leu Met Gln Gly Val Asp His Gly Val Ala Arg Gly Ser Pro Gly 

                325                 330                 335     





Arg Ala Ala Leu Gly Glu Ser Gly Glu Gln Ala Asp Gly Pro Lys Ala 

            340                 345                 350         





Thr Leu Arg Gly Asp Ser Phe Pro Asp Asp Gly Val Gln Asp Asp Asp 

        355                 360                 365             





Asp Arg Leu Tyr Gln Glu Val His Arg Leu Ser Ala Thr Leu Gly Gly 

    370                 375                 380                 





Leu Leu Gln Asp His Gly Ser Arg Leu Leu Pro Gly Ala Leu Pro Phe 

385                 390                 395                 400 





Ala Arg Pro Leu Asp Met Glu Arg Lys Lys Ser Glu His Pro Glu Ser 

                405                 410                 415     





Ser Leu Ser Ser Glu Glu Glu Thr Ala Gly Val Glu Asn Val Lys Ser 

            420                 425                 430         





Gln Thr Tyr Ser Lys Asp Leu Leu Gly Gln Gln Pro His Ser Glu Pro 

        435                 440                 445             





Gly Ala Ala Ala Phe Gly Glu Leu Gln Asn Gln Met Pro Gly Pro Ser 

    450                 455                 460                 





Lys Glu Glu Gln Ser Leu Pro Ala Gly Ala Gln Glu Ala Leu Ser Asp 

465                 470                 475                 480 





Gly Leu Gln Leu Glu Val Gln Pro Ser Glu Glu Glu Ala Arg Gly Tyr 

                485                 490                 495     





Ile Val Thr Asp Arg Asp Pro Leu Arg Pro Glu Glu Gly Arg Arg Leu 

            500                 505                 510         





Val Glu Asp Val Ala Arg Leu Leu Gln Val Pro Ser Ser Ala Phe Ala 

        515                 520                 525             





Asp Val Glu Val Leu Gly Pro Ala Val Thr Phe Lys Val Ser Ala Asn 

    530                 535                 540                 





Val Gln Asn Val Thr Thr Glu Asp Val Glu Lys Ala Thr Val Asp Asn 

545                 550                 555                 560 





Lys Asp Lys Leu Glu Glu Thr Ser Gly Leu Lys Ile Leu Gln Thr Gly 

                565                 570                 575     





Val Gly Ser Lys Ser Lys Leu Lys Phe Leu Pro Pro Gln Ala Glu Gln 

            580                 585                 590         





Glu Asp Ser Thr Lys Phe Ile Ala Leu Thr Leu Val Ser Leu Ala Cys 

        595                 600                 605             





Ile Leu Gly Val Leu Leu Ala Ser Gly Leu Ile Tyr Cys Leu Arg His 

    610                 615                 620                 





Ser Ser Gln His Arg Leu Lys Glu Lys Leu Ser Gly Leu Gly Gly Asp 

625                 630                 635                 640 





Pro Gly Ala Asp Ala Thr Ala Ala Tyr Gln Glu Leu Cys Arg Gln Arg 

                645                 650                 655     





Met Ala Thr Arg Pro Pro Asp Arg Pro Glu Gly Pro His Thr Ser Arg 

            660                 665                 670         





Ile Ser Ser Val Ser Ser Gln Phe Ser Asp Gly Pro Ile Pro Ser Pro 

        675                 680                 685             





Ser Ala Arg Ser Ser Ala Ser Ser Trp Ser Glu Glu Pro Val Gln Ser 

    690                 695                 700                 





Asn Met Asp Ile Ser Thr Gly His Met Ile Leu Ser Tyr Met Glu Asp 

705                 710                 715                 720 





His Leu Lys Asn Lys Asn Arg Leu Glu Lys Glu Trp Glu Ala Leu Cys 

                725                 730                 735     





Ala Tyr Gln Ala Glu Pro Asn Ser Ser Phe Val Ala Gln Arg Glu Glu 

            740                 745                 750         





Asn Val Pro Lys Asn Arg Ser Leu Ala Val Leu Thr Tyr Asp His Ser 

        755                 760                 765             





Arg Val Leu Leu Lys Ala Glu Asn Ser His Ser His Ser Asp Tyr Ile 

    770                 775                 780                 





Asn Ala Ser Pro Ile Met Asp His Asp Pro Arg Asn Pro Ala Tyr Ile 

785                 790                 795                 800 





Ala Thr Gln Gly Pro Leu Pro Ala Thr Val Ala Asp Phe Trp Gln Met 

                805                 810                 815     





Val Trp Glu Ser Gly Cys Val Val Ile Val Met Leu Thr Pro Leu Ala 

            820                 825                 830         





Glu Asn Gly Val Arg Gln Cys Tyr His Tyr Trp Pro Asp Glu Gly Ser 

        835                 840                 845             





Asn Leu Tyr His Ile Tyr Glu Val Asn Leu Val Ser Glu His Ile Trp 

    850                 855                 860                 





Cys Glu Asp Phe Leu Val Arg Ser Phe Tyr Leu Lys Asn Leu Gln Thr 

865                 870                 875                 880 





Asn Glu Thr Arg Thr Val Thr Gln Phe His Phe Leu Ser Trp Tyr Asp 

                885                 890                 895     





Arg Gly Val Pro Ser Ser Ser Arg Ser Leu Leu Asp Phe Arg Arg Lys 

            900                 905                 910         





Val Asn Lys Cys Tyr Arg Gly Arg Ser Cys Pro Ile Ile Val His Cys 

        915                 920                 925             





Ser Asp Gly Ala Gly Arg Ser Gly Thr Tyr Val Leu Ile Asp Met Val 

    930                 935                 940                 





Leu Asn Lys Met Ala Lys Gly Ala Lys Glu Ile Asp Ile Ala Ala Thr 

945                 950                 955                 960 





Leu Glu His Leu Arg Asp Gln Arg Pro Gly Met Val Gln Thr Lys Glu 

                965                 970                 975     





Gln Phe Glu Phe Ala Leu Thr Ala Val Ala Glu Glu Val Asn Ala Ile 

            980                 985                 990         





Leu Lys Ala Leu Pro Gln 

        995             





<210>  41

<211>  986

<212>  PRT

<213>  Homo sapiens



<400>  41



Met Gly Pro Pro Leu Pro Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro 

1               5                   10                  15      





Pro Arg Val Leu Pro Ala Ala Pro Ser Ser Val Pro Arg Gly Arg Gln 

            20                  25                  30          





Leu Pro Gly Arg Leu Gly Cys Leu Leu Glu Glu Gly Leu Cys Gly Ala 

        35                  40                  45              





Ser Glu Ala Cys Val Asn Asp Gly Val Phe Gly Arg Cys Gln Lys Val 

    50                  55                  60                  





Pro Ala Met Asp Phe Tyr Arg Tyr Glu Val Ser Pro Val Ala Leu Gln 

65                  70                  75                  80  





Arg Leu Arg Val Ala Leu Gln Lys Leu Ser Gly Thr Gly Phe Thr Trp 

                85                  90                  95      





Gln Asp Asp Tyr Thr Gln Tyr Val Met Asp Gln Glu Leu Ala Asp Leu 

            100                 105                 110         





Pro Lys Thr Tyr Leu Arg Arg Pro Glu Ala Ser Ser Pro Ala Arg Pro 

        115                 120                 125             





Ser Lys His Ser Val Gly Ser Glu Arg Arg Tyr Ser Arg Glu Gly Gly 

    130                 135                 140                 





Ala Ala Leu Ala Asn Ala Leu Arg Arg His Leu Pro Phe Leu Glu Ala 

145                 150                 155                 160 





Leu Ser Gln Ala Pro Ala Ser Asp Val Leu Ala Arg Thr His Thr Ala 

                165                 170                 175     





Gln Asp Arg Pro Pro Ala Glu Gly Asp Asp Arg Phe Ser Glu Ser Ile 

            180                 185                 190         





Leu Thr Tyr Val Ala His Thr Ser Ala Leu Thr Tyr Pro Pro Gly Ser 

        195                 200                 205             





Arg Thr Gln Leu Arg Glu Asp Leu Leu Pro Arg Thr Leu Gly Gln Leu 

    210                 215                 220                 





Gln Pro Asp Glu Leu Ser Pro Lys Val Asp Ser Gly Val Asp Arg His 

225                 230                 235                 240 





His Leu Met Ala Ala Leu Ser Ala Tyr Ala Ala Gln Arg Pro Pro Ala 

                245                 250                 255     





Pro Pro Gly Glu Gly Ser Leu Glu Pro Gln Tyr Leu Leu Arg Ala Pro 

            260                 265                 270         





Ser Arg Met Pro Arg Pro Leu Leu Ala Pro Ala Ala Pro Gln Lys Trp 

        275                 280                 285             





Pro Ser Pro Leu Gly Asp Ser Glu Asp Pro Ser Ser Thr Gly Asp Gly 

    290                 295                 300                 





Ala Arg Ile His Thr Leu Leu Lys Asp Leu Gln Arg Gln Pro Ala Glu 

305                 310                 315                 320 





Val Arg Gly Leu Ser Gly Leu Glu Leu Asp Gly Met Ala Glu Leu Met 

                325                 330                 335     





Ala Gly Leu Met Gln Gly Val Asp His Gly Val Ala Arg Gly Ser Pro 

            340                 345                 350         





Gly Arg Ala Ala Leu Gly Glu Ser Gly Glu Gln Ala Asp Gly Pro Lys 

        355                 360                 365             





Ala Thr Leu Arg Gly Asp Ser Phe Pro Asp Asp Gly Val Gln Asp Asp 

    370                 375                 380                 





Asp Asp Arg Leu Tyr Gln Glu Val His Arg Leu Ser Ala Thr Leu Gly 

385                 390                 395                 400 





Gly Leu Leu Gln Asp His Gly Ser Arg Leu Leu Pro Gly Ala Leu Pro 

                405                 410                 415     





Phe Ala Arg Pro Leu Asp Met Glu Arg Lys Lys Ser Glu His Pro Glu 

            420                 425                 430         





Ser Ser Leu Ser Ser Glu Glu Glu Thr Ala Gly Val Glu Asn Val Lys 

        435                 440                 445             





Ser Gln Thr Tyr Ser Lys Asp Leu Leu Gly Gln Gln Pro His Ser Glu 

    450                 455                 460                 





Pro Gly Ala Ala Ala Phe Gly Glu Leu Gln Asn Gln Met Pro Gly Pro 

465                 470                 475                 480 





Ser Lys Glu Glu Gln Ser Leu Pro Ala Gly Ala Gln Glu Ala Leu Ser 

                485                 490                 495     





Asp Gly Leu Gln Leu Glu Val Gln Pro Ser Glu Glu Glu Ala Arg Gly 

            500                 505                 510         





Tyr Ile Val Thr Asp Arg Glu Val Leu Gly Pro Ala Val Thr Phe Lys 

        515                 520                 525             





Val Ser Ala Asn Val Gln Asn Val Thr Thr Glu Asp Val Glu Lys Ala 

    530                 535                 540                 





Thr Val Asp Asn Lys Asp Lys Leu Glu Glu Thr Ser Gly Leu Lys Ile 

545                 550                 555                 560 





Leu Gln Thr Gly Val Gly Ser Lys Ser Lys Leu Lys Phe Leu Pro Pro 

                565                 570                 575     





Gln Ala Glu Gln Glu Asp Ser Thr Lys Phe Ile Ala Leu Thr Leu Val 

            580                 585                 590         





Ser Leu Ala Cys Ile Leu Gly Val Leu Leu Ala Ser Gly Leu Ile Tyr 

        595                 600                 605             





Cys Leu Arg His Ser Ser Gln His Arg Leu Lys Glu Lys Leu Ser Gly 

    610                 615                 620                 





Leu Gly Gly Asp Pro Gly Ala Asp Ala Thr Ala Ala Tyr Gln Glu Leu 

625                 630                 635                 640 





Cys Arg Gln Arg Met Ala Thr Arg Pro Pro Asp Arg Pro Glu Gly Pro 

                645                 650                 655     





His Thr Ser Arg Ile Ser Ser Val Ser Ser Gln Phe Ser Asp Gly Pro 

            660                 665                 670         





Ile Pro Ser Pro Ser Ala Arg Ser Ser Ala Ser Ser Trp Ser Glu Glu 

        675                 680                 685             





Pro Val Gln Ser Asn Met Asp Ile Ser Thr Gly His Met Ile Leu Ser 

    690                 695                 700                 





Tyr Met Glu Asp His Leu Lys Asn Lys Asn Arg Leu Glu Lys Glu Trp 

705                 710                 715                 720 





Glu Ala Leu Cys Ala Tyr Gln Ala Glu Pro Asn Ser Ser Phe Val Ala 

                725                 730                 735     





Gln Arg Glu Glu Asn Val Pro Lys Asn Arg Ser Leu Ala Val Leu Thr 

            740                 745                 750         





Tyr Asp His Ser Arg Val Leu Leu Lys Ala Glu Asn Ser His Ser His 

        755                 760                 765             





Ser Asp Tyr Ile Asn Ala Ser Pro Ile Met Asp His Asp Pro Arg Asn 

    770                 775                 780                 





Pro Ala Tyr Ile Ala Thr Gln Gly Pro Leu Pro Ala Thr Val Ala Asp 

785                 790                 795                 800 





Phe Trp Gln Met Val Trp Glu Ser Gly Cys Val Val Ile Val Met Leu 

                805                 810                 815     





Thr Pro Leu Ala Glu Asn Gly Val Arg Gln Cys Tyr His Tyr Trp Pro 

            820                 825                 830         





Asp Glu Gly Ser Asn Leu Tyr His Ile Tyr Glu Val Asn Leu Val Ser 

        835                 840                 845             





Glu His Ile Trp Cys Glu Asp Phe Leu Val Arg Ser Phe Tyr Leu Lys 

    850                 855                 860                 





Asn Leu Gln Thr Asn Glu Thr Arg Thr Val Thr Gln Phe His Phe Leu 

865                 870                 875                 880 





Ser Trp Tyr Asp Arg Gly Val Pro Ser Ser Ser Arg Ser Leu Leu Asp 

                885                 890                 895     





Phe Arg Arg Lys Val Asn Lys Cys Tyr Arg Gly Arg Ser Cys Pro Ile 

            900                 905                 910         





Ile Val His Cys Ser Asp Gly Ala Gly Arg Ser Gly Thr Tyr Val Leu 

        915                 920                 925             





Ile Asp Met Val Leu Asn Lys Met Ala Lys Gly Ala Lys Glu Ile Asp 

    930                 935                 940                 





Ile Ala Ala Thr Leu Glu His Leu Arg Asp Gln Arg Pro Gly Met Val 

945                 950                 955                 960 





Gln Thr Lys Glu Gln Phe Glu Phe Ala Leu Thr Ala Val Ala Glu Glu 

                965                 970                 975     





Val Asn Ala Ile Leu Lys Ala Leu Pro Gln 

            980                 985     





<210>  42

<211>  1015

<212>  PRT

<213>  Homo sapiens



<400>  42



Met Gly Pro Pro Leu Pro Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro 

1               5                   10                  15      





Pro Arg Val Leu Pro Ala Ala Pro Ser Ser Val Pro Arg Gly Arg Gln 

            20                  25                  30          





Leu Pro Gly Arg Leu Gly Cys Leu Leu Glu Glu Gly Leu Cys Gly Ala 

        35                  40                  45              





Ser Glu Ala Cys Val Asn Asp Gly Val Phe Gly Arg Cys Gln Lys Val 

    50                  55                  60                  





Pro Ala Met Asp Phe Tyr Arg Tyr Glu Val Ser Pro Val Ala Leu Gln 

65                  70                  75                  80  





Arg Leu Arg Val Ala Leu Gln Lys Leu Ser Gly Thr Gly Phe Thr Trp 

                85                  90                  95      





Gln Asp Asp Tyr Thr Gln Tyr Val Met Asp Gln Glu Leu Ala Asp Leu 

            100                 105                 110         





Pro Lys Thr Tyr Leu Arg Arg Pro Glu Ala Ser Ser Pro Ala Arg Pro 

        115                 120                 125             





Ser Lys His Ser Val Gly Ser Glu Arg Arg Tyr Ser Arg Glu Gly Gly 

    130                 135                 140                 





Ala Ala Leu Ala Asn Ala Leu Arg Arg His Leu Pro Phe Leu Glu Ala 

145                 150                 155                 160 





Leu Ser Gln Ala Pro Ala Ser Asp Val Leu Ala Arg Thr His Thr Ala 

                165                 170                 175     





Gln Asp Arg Pro Pro Ala Glu Gly Asp Asp Arg Phe Ser Glu Ser Ile 

            180                 185                 190         





Leu Thr Tyr Val Ala His Thr Ser Ala Leu Thr Tyr Pro Pro Gly Ser 

        195                 200                 205             





Arg Thr Gln Leu Arg Glu Asp Leu Leu Pro Arg Thr Leu Gly Gln Leu 

    210                 215                 220                 





Gln Pro Asp Glu Leu Ser Pro Lys Val Asp Ser Gly Val Asp Arg His 

225                 230                 235                 240 





His Leu Met Ala Ala Leu Ser Ala Tyr Ala Ala Gln Arg Pro Pro Ala 

                245                 250                 255     





Pro Pro Gly Glu Gly Ser Leu Glu Pro Gln Tyr Leu Leu Arg Ala Pro 

            260                 265                 270         





Ser Arg Met Pro Arg Pro Leu Leu Ala Pro Ala Ala Pro Gln Lys Trp 

        275                 280                 285             





Pro Ser Pro Leu Gly Asp Ser Glu Asp Pro Ser Ser Thr Gly Asp Gly 

    290                 295                 300                 





Ala Arg Ile His Thr Leu Leu Lys Asp Leu Gln Arg Gln Pro Ala Glu 

305                 310                 315                 320 





Val Arg Gly Leu Ser Gly Leu Glu Leu Asp Gly Met Ala Glu Leu Met 

                325                 330                 335     





Ala Gly Leu Met Gln Gly Val Asp His Gly Val Ala Arg Gly Ser Pro 

            340                 345                 350         





Gly Arg Ala Ala Leu Gly Glu Ser Gly Glu Gln Ala Asp Gly Pro Lys 

        355                 360                 365             





Ala Thr Leu Arg Gly Asp Ser Phe Pro Asp Asp Gly Val Gln Asp Asp 

    370                 375                 380                 





Asp Asp Arg Leu Tyr Gln Glu Val His Arg Leu Ser Ala Thr Leu Gly 

385                 390                 395                 400 





Gly Leu Leu Gln Asp His Gly Ser Arg Leu Leu Pro Gly Ala Leu Pro 

                405                 410                 415     





Phe Ala Arg Pro Leu Asp Met Glu Arg Lys Lys Ser Glu His Pro Glu 

            420                 425                 430         





Ser Ser Leu Ser Ser Glu Glu Glu Thr Ala Gly Val Glu Asn Val Lys 

        435                 440                 445             





Ser Gln Thr Tyr Ser Lys Asp Leu Leu Gly Gln Gln Pro His Ser Glu 

    450                 455                 460                 





Pro Gly Ala Ala Ala Phe Gly Glu Leu Gln Asn Gln Met Pro Gly Pro 

465                 470                 475                 480 





Ser Lys Glu Glu Gln Ser Leu Pro Ala Gly Ala Gln Glu Ala Leu Ser 

                485                 490                 495     





Asp Gly Leu Gln Leu Glu Val Gln Pro Ser Glu Glu Glu Ala Arg Gly 

            500                 505                 510         





Tyr Ile Val Thr Asp Arg Asp Pro Leu Arg Pro Glu Glu Gly Arg Arg 

        515                 520                 525             





Leu Val Glu Asp Val Ala Arg Leu Leu Gln Val Pro Ser Ser Ala Phe 

    530                 535                 540                 





Ala Asp Val Glu Val Leu Gly Pro Ala Val Thr Phe Lys Val Ser Ala 

545                 550                 555                 560 





Asn Val Gln Asn Val Thr Thr Glu Asp Val Glu Lys Ala Thr Val Asp 

                565                 570                 575     





Asn Lys Asp Lys Leu Glu Glu Thr Ser Gly Leu Lys Ile Leu Gln Thr 

            580                 585                 590         





Gly Val Gly Ser Lys Ser Lys Leu Lys Phe Leu Pro Pro Gln Ala Glu 

        595                 600                 605             





Gln Glu Asp Ser Thr Lys Phe Ile Ala Leu Thr Leu Val Ser Leu Ala 

    610                 615                 620                 





Cys Ile Leu Gly Val Leu Leu Ala Ser Gly Leu Ile Tyr Cys Leu Arg 

625                 630                 635                 640 





His Ser Ser Gln His Arg Leu Lys Glu Lys Leu Ser Gly Leu Gly Gly 

                645                 650                 655     





Asp Pro Gly Ala Asp Ala Thr Ala Ala Tyr Gln Glu Leu Cys Arg Gln 

            660                 665                 670         





Arg Met Ala Thr Arg Pro Pro Asp Arg Pro Glu Gly Pro His Thr Ser 

        675                 680                 685             





Arg Ile Ser Ser Val Ser Ser Gln Phe Ser Asp Gly Pro Ile Pro Ser 

    690                 695                 700                 





Pro Ser Ala Arg Ser Ser Ala Ser Ser Trp Ser Glu Glu Pro Val Gln 

705                 710                 715                 720 





Ser Asn Met Asp Ile Ser Thr Gly His Met Ile Leu Ser Tyr Met Glu 

                725                 730                 735     





Asp His Leu Lys Asn Lys Asn Arg Leu Glu Lys Glu Trp Glu Ala Leu 

            740                 745                 750         





Cys Ala Tyr Gln Ala Glu Pro Asn Ser Ser Phe Val Ala Gln Arg Glu 

        755                 760                 765             





Glu Asn Val Pro Lys Asn Arg Ser Leu Ala Val Leu Thr Tyr Asp His 

    770                 775                 780                 





Ser Arg Val Leu Leu Lys Ala Glu Asn Ser His Ser His Ser Asp Tyr 

785                 790                 795                 800 





Ile Asn Ala Ser Pro Ile Met Asp His Asp Pro Arg Asn Pro Ala Tyr 

                805                 810                 815     





Ile Ala Thr Gln Gly Pro Leu Pro Ala Thr Val Ala Asp Phe Trp Gln 

            820                 825                 830         





Met Val Trp Glu Ser Gly Cys Val Val Ile Val Met Leu Thr Pro Leu 

        835                 840                 845             





Ala Glu Asn Gly Val Arg Gln Cys Tyr His Tyr Trp Pro Asp Glu Gly 

    850                 855                 860                 





Ser Asn Leu Tyr His Ile Tyr Glu Val Asn Leu Val Ser Glu His Ile 

865                 870                 875                 880 





Trp Cys Glu Asp Phe Leu Val Arg Ser Phe Tyr Leu Lys Asn Leu Gln 

                885                 890                 895     





Thr Asn Glu Thr Arg Thr Val Thr Gln Phe His Phe Leu Ser Trp Tyr 

            900                 905                 910         





Asp Arg Gly Val Pro Ser Ser Ser Arg Ser Leu Leu Asp Phe Arg Arg 

        915                 920                 925             





Lys Val Asn Lys Cys Tyr Arg Gly Arg Ser Cys Pro Ile Ile Val His 

    930                 935                 940                 





Cys Ser Asp Gly Ala Gly Arg Ser Gly Thr Tyr Val Leu Ile Asp Met 

945                 950                 955                 960 





Val Leu Asn Lys Met Ala Lys Gly Ala Lys Glu Ile Asp Ile Ala Ala 

                965                 970                 975     





Thr Leu Glu His Leu Arg Asp Gln Arg Pro Gly Met Val Gln Thr Lys 

            980                 985                 990         





Glu Gln Phe Glu Phe Ala Leu Thr  Ala Val Ala Glu Glu  Val Asn Ala 

        995                 1000                 1005             





Ile Leu  Lys Ala Leu Pro Gln  

    1010                 1015 





<210>  43

<211>  355

<212>  PRT

<213>  Homo sapiens



<400>  43



Met Asp Phe Leu His Arg Asn Gly Val Leu Ile Ile Gln His Leu Gln 

1               5                   10                  15      





Lys Asp Tyr Arg Ala Tyr Tyr Thr Phe Leu Asn Phe Met Ser Asn Val 

            20                  25                  30          





Gly Asp Pro Arg Asn Ile Phe Phe Ile Tyr Phe Pro Leu Cys Phe Gln 

        35                  40                  45              





Phe Asn Gln Thr Val Gly Thr Lys Met Ile Trp Val Ala Val Ile Gly 

    50                  55                  60                  





Asp Trp Leu Asn Leu Ile Phe Lys Trp Ile Leu Phe Gly His Arg Pro 

65                  70                  75                  80  





Tyr Trp Trp Val Gln Glu Thr Gln Ile Tyr Pro Asn His Ser Ser Pro 

                85                  90                  95      





Cys Leu Glu Gln Phe Pro Thr Thr Cys Glu Thr Gly Pro Gly Ser Pro 

            100                 105                 110         





Ser Gly His Ala Met Gly Ala Ser Cys Val Trp Tyr Val Met Val Thr 

        115                 120                 125             





Ala Ala Leu Ser His Thr Val Cys Gly Met Asp Lys Phe Ser Ile Thr 

    130                 135                 140                 





Leu His Arg Leu Thr Trp Ser Phe Leu Trp Ser Val Phe Trp Leu Ile 

145                 150                 155                 160 





Gln Ile Ser Val Cys Ile Ser Arg Val Phe Ile Ala Thr His Phe Pro 

                165                 170                 175     





His Gln Val Ile Leu Gly Val Ile Gly Gly Met Leu Val Ala Glu Ala 

            180                 185                 190         





Phe Glu His Thr Pro Gly Ile Gln Thr Ala Ser Leu Gly Thr Tyr Leu 

        195                 200                 205             





Lys Thr Asn Leu Phe Leu Phe Leu Phe Ala Val Gly Phe Tyr Leu Leu 

    210                 215                 220                 





Leu Arg Val Leu Asn Ile Asp Leu Leu Trp Ser Val Pro Ile Ala Lys 

225                 230                 235                 240 





Lys Trp Cys Ala Asn Pro Asp Trp Ile His Ile Asp Thr Thr Pro Phe 

                245                 250                 255     





Ala Gly Leu Val Arg Asn Leu Gly Val Leu Phe Gly Leu Gly Phe Ala 

            260                 265                 270         





Ile Asn Ser Glu Met Phe Leu Leu Ser Cys Arg Gly Gly Asn Asn Tyr 

        275                 280                 285             





Thr Leu Ser Phe Arg Leu Leu Cys Ala Leu Thr Ser Leu Thr Ile Leu 

    290                 295                 300                 





Gln Leu Tyr His Phe Leu Gln Ile Pro Thr His Glu Glu His Leu Phe 

305                 310                 315                 320 





Tyr Val Leu Ser Phe Cys Lys Ser Ala Ser Ile Pro Leu Thr Val Val 

                325                 330                 335     





Ala Phe Ile Pro Tyr Ser Val His Met Leu Met Lys Gln Ser Gly Lys 

            340                 345                 350         





Lys Ser Gln 

        355 





<210>  44

<211>  154

<212>  PRT

<213>  Homo sapiens



<400>  44



Met Asp Phe Leu His Arg Asn Gly Val Leu Ile Ile Gln His Leu Gln 

1               5                   10                  15      





Lys Asp Tyr Arg Ala Tyr Tyr Thr Phe Leu Asn Phe Met Ser Asn Val 

            20                  25                  30          





Gly Asp Pro Arg Asn Ile Phe Phe Ile Tyr Phe Pro Leu Cys Phe Gln 

        35                  40                  45              





Phe Asn Gln Thr Val Gly Thr Lys Met Ile Trp Val Ala Val Ile Gly 

    50                  55                  60                  





Asp Trp Leu Asn Leu Ile Phe Lys Trp Ile Leu Phe Gly His Arg Pro 

65                  70                  75                  80  





Tyr Trp Trp Val Gln Glu Thr Gln Ile Tyr Pro Asn His Ser Ser Pro 

                85                  90                  95      





Cys Leu Glu Gln Phe Pro Thr Thr Cys Glu Thr Gly Pro Gly Ser Pro 

            100                 105                 110         





Ser Gly His Ala Met Gly Ala Ser Cys Val Trp Tyr Val Met Val Thr 

        115                 120                 125             





Ala Ala Leu Ser His Thr Val Cys Gly Met Asp Lys Phe Ser Ile Thr 

    130                 135                 140                 





Leu His Arg His Ala Gly Gly Arg Gly Leu 

145                 150                 





<210>  45

<211>  457

<212>  PRT

<213>  Homo sapiens



<400>  45



Met Arg Ser Ala Ala Val Leu Ala Leu Leu Leu Cys Ala Gly Gln Val 

1               5                   10                  15      





Thr Ala Leu Pro Val Asn Ser Pro Met Asn Lys Gly Asp Thr Glu Val 

            20                  25                  30          





Met Lys Cys Ile Val Glu Val Ile Ser Asp Thr Leu Ser Lys Pro Ser 

        35                  40                  45              





Pro Met Pro Val Ser Gln Glu Cys Phe Glu Thr Leu Arg Gly Asp Glu 

    50                  55                  60                  





Arg Ile Leu Ser Ile Leu Arg His Gln Asn Leu Leu Lys Glu Leu Gln 

65                  70                  75                  80  





Asp Leu Ala Leu Gln Gly Ala Lys Glu Arg Ala His Gln Gln Lys Lys 

                85                  90                  95      





His Ser Gly Phe Glu Asp Glu Leu Ser Glu Val Leu Glu Asn Gln Ser 

            100                 105                 110         





Ser Gln Ala Glu Leu Lys Glu Ala Val Glu Glu Pro Ser Ser Lys Asp 

        115                 120                 125             





Val Met Glu Lys Arg Glu Asp Ser Lys Glu Ala Glu Lys Ser Gly Glu 

    130                 135                 140                 





Ala Thr Asp Gly Ala Arg Pro Gln Ala Leu Pro Glu Pro Met Gln Glu 

145                 150                 155                 160 





Ser Lys Ala Glu Gly Asn Asn Gln Ala Pro Gly Glu Glu Glu Glu Glu 

                165                 170                 175     





Glu Glu Glu Ala Thr Asn Thr His Pro Pro Ala Ser Leu Pro Ser Gln 

            180                 185                 190         





Lys Tyr Pro Gly Pro Gln Ala Glu Gly Asp Ser Glu Gly Leu Ser Gln 

        195                 200                 205             





Gly Leu Val Asp Arg Glu Lys Gly Leu Ser Ala Glu Pro Gly Trp Gln 

    210                 215                 220                 





Ala Lys Arg Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Glu Ala Gly 

225                 230                 235                 240 





Glu Glu Ala Val Pro Glu Glu Glu Gly Pro Thr Val Val Leu Asn Pro 

                245                 250                 255     





His Pro Ser Leu Gly Tyr Lys Glu Ile Arg Lys Gly Glu Ser Arg Ser 

            260                 265                 270         





Glu Ala Leu Ala Val Asp Gly Ala Gly Lys Pro Gly Ala Glu Glu Ala 

        275                 280                 285             





Gln Asp Pro Glu Gly Lys Gly Glu Gln Glu His Ser Gln Gln Lys Glu 

    290                 295                 300                 





Glu Glu Glu Glu Met Ala Val Val Pro Gln Gly Leu Phe Arg Gly Gly 

305                 310                 315                 320 





Lys Ser Gly Glu Leu Glu Gln Glu Glu Glu Arg Leu Ser Lys Glu Trp 

                325                 330                 335     





Glu Asp Ser Lys Arg Trp Ser Lys Met Asp Gln Leu Ala Lys Glu Leu 

            340                 345                 350         





Thr Ala Glu Lys Arg Leu Glu Gly Gln Glu Glu Glu Glu Asp Asn Arg 

        355                 360                 365             





Asp Ser Ser Met Lys Leu Ser Phe Arg Ala Arg Ala Tyr Gly Phe Arg 

    370                 375                 380                 





Gly Pro Gly Pro Gln Leu Arg Arg Gly Trp Arg Pro Ser Ser Arg Glu 

385                 390                 395                 400 





Asp Ser Leu Glu Ala Gly Leu Pro Leu Gln Val Arg Gly Tyr Pro Glu 

                405                 410                 415     





Glu Lys Lys Glu Glu Glu Gly Ser Ala Asn Arg Arg Pro Glu Asp Gln 

            420                 425                 430         





Glu Leu Glu Ser Leu Ser Ala Ile Glu Ala Glu Leu Glu Lys Val Ala 

        435                 440                 445             





His Gln Leu Gln Ala Leu Arg Arg Gly 

    450                 455         





<210>  46

<211>  369

<212>  PRT

<213>  Homo sapiens



<400>  46



Met Glu Phe Leu Glu Arg Thr Tyr Leu Val Asn Asp Lys Ala Ala Lys 

1               5                   10                  15      





Met Tyr Ala Phe Thr Leu Glu Ser Val Glu Leu Gln Gln Lys Pro Val 

            20                  25                  30          





Asn Lys Asp Gln Cys Pro Arg Glu Arg Pro Glu Glu Leu Glu Ser Gly 

        35                  40                  45              





Gly Met Tyr His Cys His Ser Gly Ser Lys Pro Thr Glu Lys Gly Ala 

    50                  55                  60                  





Asn Glu Tyr Ala Tyr Ala Lys Trp Lys Leu Cys Ser Ala Ser Ala Ile 

65                  70                  75                  80  





Cys Phe Ile Phe Met Ile Ala Glu Val Val Gly Gly His Ile Ala Gly 

                85                  90                  95      





Ser Leu Ala Val Val Thr Asp Ala Ala His Leu Leu Ile Asp Leu Thr 

            100                 105                 110         





Ser Phe Leu Leu Ser Leu Phe Ser Leu Trp Leu Ser Ser Lys Pro Pro 

        115                 120                 125             





Ser Lys Arg Leu Thr Phe Gly Trp His Arg Ala Glu Ile Leu Gly Ala 

    130                 135                 140                 





Leu Leu Ser Ile Leu Cys Ile Trp Val Val Thr Gly Val Leu Val Tyr 

145                 150                 155                 160 





Leu Ala Cys Glu Arg Leu Leu Tyr Pro Asp Tyr Gln Ile Gln Ala Thr 

                165                 170                 175     





Val Met Ile Ile Val Ser Ser Cys Ala Val Ala Ala Asn Ile Val Leu 

            180                 185                 190         





Thr Val Val Leu His Gln Arg Cys Leu Gly His Asn His Lys Glu Val 

        195                 200                 205             





Gln Ala Asn Ala Ser Val Arg Ala Ala Phe Val His Ala Leu Gly Asp 

    210                 215                 220                 





Leu Phe Gln Ser Ile Ser Val Leu Ile Ser Ala Leu Ile Ile Tyr Phe 

225                 230                 235                 240 





Lys Pro Glu Tyr Lys Ile Ala Asp Pro Ile Cys Thr Phe Ile Phe Ser 

                245                 250                 255     





Ile Leu Val Leu Ala Ser Thr Ile Thr Ile Leu Lys Asp Phe Ser Ile 

            260                 265                 270         





Leu Leu Met Glu Gly Val Pro Lys Ser Leu Asn Tyr Ser Gly Val Lys 

        275                 280                 285             





Glu Leu Ile Leu Ala Val Asp Gly Val Leu Ser Val His Ser Leu His 

    290                 295                 300                 





Ile Trp Ser Leu Thr Met Asn Gln Val Ile Leu Ser Ala His Val Ala 

305                 310                 315                 320 





Thr Ala Ala Ser Arg Asp Ser Gln Val Val Arg Arg Glu Ile Ala Lys 

                325                 330                 335     





Ala Leu Ser Lys Ser Phe Thr Met His Ser Leu Thr Ile Gln Met Glu 

            340                 345                 350         





Ser Pro Val Asp Gln Asp Pro Asp Cys Leu Phe Cys Glu Asp Pro Cys 

        355                 360                 365             





Asp 

    





<210>  47

<211>  573

<212>  PRT

<213>  Homo sapiens



<400>  47



Met Leu Arg Leu Pro Thr Val Phe Arg Gln Met Arg Pro Val Ser Arg 

1               5                   10                  15      





Val Leu Ala Pro His Leu Thr Arg Ala Tyr Ala Lys Asp Val Lys Phe 

            20                  25                  30          





Gly Ala Asp Ala Arg Ala Leu Met Leu Gln Gly Val Asp Leu Leu Ala 

        35                  40                  45              





Asp Ala Val Ala Val Thr Met Gly Pro Lys Gly Arg Thr Val Ile Ile 

    50                  55                  60                  





Glu Gln Ser Trp Gly Ser Pro Lys Val Thr Lys Asp Gly Val Thr Val 

65                  70                  75                  80  





Ala Lys Ser Ile Asp Leu Lys Asp Lys Tyr Lys Asn Ile Gly Ala Lys 

                85                  90                  95      





Leu Val Gln Asp Val Ala Asn Asn Thr Asn Glu Glu Ala Gly Asp Gly 

            100                 105                 110         





Thr Thr Thr Ala Thr Val Leu Ala Arg Ser Ile Ala Lys Glu Gly Phe 

        115                 120                 125             





Glu Lys Ile Ser Lys Gly Ala Asn Pro Val Glu Ile Arg Arg Gly Val 

    130                 135                 140                 





Met Leu Ala Val Asp Ala Val Ile Ala Glu Leu Lys Lys Gln Ser Lys 

145                 150                 155                 160 





Pro Val Thr Thr Pro Glu Glu Ile Ala Gln Val Ala Thr Ile Ser Ala 

                165                 170                 175     





Asn Gly Asp Lys Glu Ile Gly Asn Ile Ile Ser Asp Ala Met Lys Lys 

            180                 185                 190         





Val Gly Arg Lys Gly Val Ile Thr Val Lys Asp Gly Lys Thr Leu Asn 

        195                 200                 205             





Asp Glu Leu Glu Ile Ile Glu Gly Met Lys Phe Asp Arg Gly Tyr Ile 

    210                 215                 220                 





Ser Pro Tyr Phe Ile Asn Thr Ser Lys Gly Gln Lys Cys Glu Phe Gln 

225                 230                 235                 240 





Asp Ala Tyr Val Leu Leu Ser Glu Lys Lys Ile Ser Ser Ile Gln Ser 

                245                 250                 255     





Ile Val Pro Ala Leu Glu Ile Ala Asn Ala His Arg Lys Pro Leu Val 

            260                 265                 270         





Ile Ile Ala Glu Asp Val Asp Gly Glu Ala Leu Ser Thr Leu Val Leu 

        275                 280                 285             





Asn Arg Leu Lys Val Gly Leu Gln Val Val Ala Val Lys Ala Pro Gly 

    290                 295                 300                 





Phe Gly Asp Asn Arg Lys Asn Gln Leu Lys Asp Met Ala Ile Ala Thr 

305                 310                 315                 320 





Gly Gly Ala Val Phe Gly Glu Glu Gly Leu Thr Leu Asn Leu Glu Asp 

                325                 330                 335     





Val Gln Pro His Asp Leu Gly Lys Val Gly Glu Val Ile Val Thr Lys 

            340                 345                 350         





Asp Asp Ala Met Leu Leu Lys Gly Lys Gly Asp Lys Ala Gln Ile Glu 

        355                 360                 365             





Lys Arg Ile Gln Glu Ile Ile Glu Gln Leu Asp Val Thr Thr Ser Glu 

    370                 375                 380                 





Tyr Glu Lys Glu Lys Leu Asn Glu Arg Leu Ala Lys Leu Ser Asp Gly 

385                 390                 395                 400 





Val Ala Val Leu Lys Val Gly Gly Thr Ser Asp Val Glu Val Asn Glu 

                405                 410                 415     





Lys Lys Asp Arg Val Thr Asp Ala Leu Asn Ala Thr Arg Ala Ala Val 

            420                 425                 430         





Glu Glu Gly Ile Val Leu Gly Gly Gly Cys Ala Leu Leu Arg Cys Ile 

        435                 440                 445             





Pro Ala Leu Asp Ser Leu Thr Pro Ala Asn Glu Asp Gln Lys Ile Gly 

    450                 455                 460                 





Ile Glu Ile Ile Lys Arg Thr Leu Lys Ile Pro Ala Met Thr Ile Ala 

465                 470                 475                 480 





Lys Asn Ala Gly Val Glu Gly Ser Leu Ile Val Glu Lys Ile Met Gln 

                485                 490                 495     





Ser Ser Ser Glu Val Gly Tyr Asp Ala Met Ala Gly Asp Phe Val Asn 

            500                 505                 510         





Met Val Glu Lys Gly Ile Ile Asp Pro Thr Lys Val Val Arg Thr Ala 

        515                 520                 525             





Leu Leu Asp Ala Ala Gly Val Ala Ser Leu Leu Thr Thr Ala Glu Val 

    530                 535                 540                 





Val Val Thr Glu Ile Pro Lys Glu Glu Lys Asp Pro Gly Met Gly Ala 

545                 550                 555                 560 





Met Gly Gly Met Gly Gly Gly Met Gly Gly Gly Met Phe 

                565                 570             





<210>  48

<211>  641

<212>  PRT

<213>  Homo sapiens



<400>  48



Met Ala Lys Ala Ala Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr Ser 

1               5                   10                  15      





Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 

            20                  25                  30          





Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 

        35                  40                  45              





Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Leu Asn Pro Gln 

    50                  55                  60                  





Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Gly Asp 

65                  70                  75                  80  





Pro Val Val Gln Ser Asp Met Lys His Trp Pro Phe Gln Val Ile Asn 

                85                  90                  95      





Asp Gly Asp Lys Pro Lys Val Gln Val Ser Tyr Lys Gly Glu Thr Lys 

            100                 105                 110         





Ala Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met Lys 

        115                 120                 125             





Glu Ile Ala Glu Ala Tyr Leu Gly Tyr Pro Val Thr Asn Ala Val Ile 

    130                 135                 140                 





Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 

145                 150                 155                 160 





Ala Gly Val Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 

                165                 170                 175     





Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg Thr Gly Lys Gly Glu 

            180                 185                 190         





Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 

        195                 200                 205             





Ile Leu Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr Ala Gly 

    210                 215                 220                 





Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val Asn His 

225                 230                 235                 240 





Phe Val Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Gln Asn 

                245                 250                 255     





Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 

            260                 265                 270         





Thr Leu Ser Ser Ser Thr Gln Ala Ser Leu Glu Ile Asp Ser Leu Phe 

        275                 280                 285             





Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 

    290                 295                 300                 





Leu Cys Ser Asp Leu Phe Arg Ser Thr Leu Glu Pro Val Glu Lys Ala 

305                 310                 315                 320 





Leu Arg Asp Ala Lys Leu Asp Lys Ala Gln Ile His Asp Leu Val Leu 

                325                 330                 335     





Val Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Lys Leu Leu Gln Asp 

            340                 345                 350         





Phe Phe Asn Gly Arg Asp Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 

        355                 360                 365             





Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Met Gly Asp Lys 

    370                 375                 380                 





Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro Leu Ser 

385                 390                 395                 400 





Leu Gly Leu Glu Thr Ala Gly Gly Val Met Thr Ala Leu Ile Lys Arg 

                405                 410                 415     





Asn Ser Thr Ile Pro Thr Lys Gln Thr Gln Ile Phe Thr Thr Tyr Ser 

            420                 425                 430         





Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 

        435                 440                 445             





Met Thr Lys Asp Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser Gly Ile 

    450                 455                 460                 





Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 

465                 470                 475                 480 





Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Thr Asp Lys Ser Thr Gly 

                485                 490                 495     





Lys Ala Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 

            500                 505                 510         





Glu Glu Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 

        515                 520                 525             





Asp Glu Val Gln Arg Glu Arg Val Ser Ala Lys Asn Ala Leu Glu Ser 

    530                 535                 540                 





Tyr Ala Phe Asn Met Lys Ser Ala Val Glu Asp Glu Gly Leu Lys Gly 

545                 550                 555                 560 





Lys Ile Ser Glu Ala Asp Lys Lys Lys Val Leu Asp Lys Cys Gln Glu 

                565                 570                 575     





Val Ile Ser Trp Leu Asp Ala Asn Thr Leu Ala Glu Lys Asp Glu Phe 

            580                 585                 590         





Glu His Lys Arg Lys Glu Leu Glu Gln Val Cys Asn Pro Ile Ile Ser 

        595                 600                 605             





Gly Leu Tyr Gln Gly Ala Gly Gly Pro Gly Pro Gly Gly Phe Gly Ala 

    610                 615                 620                 





Gln Gly Pro Lys Gly Gly Ser Gly Ser Gly Pro Thr Ile Glu Glu Val 

625                 630                 635                 640 





Asp 

    





<210>  49

<211>  641

<212>  PRT

<213>  Homo sapiens



<400>  49



Met Ala Lys Ala Ala Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr Ser 

1               5                   10                  15      





Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 

            20                  25                  30          





Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 

        35                  40                  45              





Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Leu Asn Pro Gln 

    50                  55                  60                  





Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Gly Asp 

65                  70                  75                  80  





Pro Val Val Gln Ser Asp Met Lys His Trp Pro Phe Gln Val Ile Asn 

                85                  90                  95      





Asp Gly Asp Lys Pro Lys Val Gln Val Ser Tyr Lys Gly Glu Thr Lys 

            100                 105                 110         





Ala Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met Lys 

        115                 120                 125             





Glu Ile Ala Glu Ala Tyr Leu Gly Tyr Pro Val Thr Asn Ala Val Ile 

    130                 135                 140                 





Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 

145                 150                 155                 160 





Ala Gly Val Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 

                165                 170                 175     





Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg Thr Gly Lys Gly Glu 

            180                 185                 190         





Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 

        195                 200                 205             





Ile Leu Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr Ala Gly 

    210                 215                 220                 





Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val Asn His 

225                 230                 235                 240 





Phe Val Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Gln Asn 

                245                 250                 255     





Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 

            260                 265                 270         





Thr Leu Ser Ser Ser Thr Gln Ala Ser Leu Glu Ile Asp Ser Leu Phe 

        275                 280                 285             





Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 

    290                 295                 300                 





Leu Cys Ser Asp Leu Phe Arg Ser Thr Leu Glu Pro Val Glu Lys Ala 

305                 310                 315                 320 





Leu Arg Asp Ala Lys Leu Asp Lys Ala Gln Ile His Asp Leu Val Leu 

                325                 330                 335     





Val Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Lys Leu Leu Gln Asp 

            340                 345                 350         





Phe Phe Asn Gly Arg Asp Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 

        355                 360                 365             





Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Met Gly Asp Lys 

    370                 375                 380                 





Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro Leu Ser 

385                 390                 395                 400 





Leu Gly Leu Glu Thr Ala Gly Gly Val Met Thr Ala Leu Ile Lys Arg 

                405                 410                 415     





Asn Ser Thr Ile Pro Thr Lys Gln Thr Gln Ile Phe Thr Thr Tyr Ser 

            420                 425                 430         





Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 

        435                 440                 445             





Met Thr Lys Asp Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser Gly Ile 

    450                 455                 460                 





Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 

465                 470                 475                 480 





Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Thr Asp Lys Ser Thr Gly 

                485                 490                 495     





Lys Ala Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 

            500                 505                 510         





Glu Glu Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 

        515                 520                 525             





Asp Glu Val Gln Arg Glu Arg Val Ser Ala Lys Asn Ala Leu Glu Ser 

    530                 535                 540                 





Tyr Ala Phe Asn Met Lys Ser Ala Val Glu Asp Glu Gly Leu Lys Gly 

545                 550                 555                 560 





Lys Ile Ser Glu Ala Asp Lys Lys Lys Val Leu Asp Lys Cys Gln Glu 

                565                 570                 575     





Val Ile Ser Trp Leu Asp Ala Asn Thr Leu Ala Glu Lys Asp Glu Phe 

            580                 585                 590         





Glu His Lys Arg Lys Glu Leu Glu Gln Val Cys Asn Pro Ile Ile Ser 

        595                 600                 605             





Gly Leu Tyr Gln Gly Ala Gly Gly Pro Gly Pro Gly Gly Phe Gly Ala 

    610                 615                 620                 





Gln Gly Pro Lys Gly Gly Ser Gly Ser Gly Pro Thr Ile Glu Glu Val 

625                 630                 635                 640 





Asp 

    





<210>  50

<211>  2824

<212>  PRT

<213>  Homo sapiens



<400>  50



Gly Cys Gly Gly Cys Cys Gly Cys Cys Cys Gly Cys Ala Cys Thr Thr 

1               5                   10                  15      





Cys Cys Cys Gly Cys Cys Thr Cys Thr Gly Gly Cys Thr Cys Gly Cys 

            20                  25                  30          





Cys Cys Gly Ala Gly Gly Ala Cys Gly Cys Gly Cys Thr Gly Gly Cys 

        35                  40                  45              





Ala Cys Gly Cys Cys Thr Cys Cys Cys Ala Cys Cys Cys Cys Cys Thr 

    50                  55                  60                  





Cys Ala Cys Thr Cys Thr Gly Ala Cys Thr Cys Cys Ala Gly Cys Thr 

65                  70                  75                  80  





Gly Gly Cys Gly Thr Gly Cys Ala Thr Gly Gly Thr Cys Thr Gly Cys 

                85                  90                  95      





Cys Thr Cys Gly Cys Ala Thr Cys Cys Thr Cys Ala Cys Gly Ala Cys 

            100                 105                 110         





Thr Cys Ala Gly Cys Thr Cys Cys Cys Thr Cys Cys Cys Thr Cys Thr 

        115                 120                 125             





Cys Thr Cys Gly Thr Gly Thr Thr Thr Thr Thr Thr Thr Cys Cys Thr 

    130                 135                 140                 





Cys Cys Gly Cys Cys Gly Cys Cys Cys Cys Cys Thr Cys Ala Thr Thr 

145                 150                 155                 160 





Cys Ala Thr Cys Cys Cys Cys Ala Cys Thr Gly Gly Gly Cys Thr Cys 

                165                 170                 175     





Cys Cys Thr Thr Thr Cys Cys Cys Thr Cys Ala Ala Ala Thr Gly Cys 

            180                 185                 190         





Thr Cys Thr Gly Gly Gly Gly Cys Thr Cys Thr Cys Cys Gly Cys Gly 

        195                 200                 205             





Cys Thr Thr Thr Cys Cys Thr Gly Ala Gly Thr Cys Cys Gly Gly Gly 

    210                 215                 220                 





Cys Thr Cys Cys Gly Ala Gly Gly Ala Cys Cys Cys Thr Thr Ala Gly 

225                 230                 235                 240 





Gly Thr Ala Gly Thr Cys Cys Cys Gly Gly Thr Cys Thr Cys Thr Thr 

                245                 250                 255     





Thr Thr Ala Ala Ala Gly Cys Thr Cys Cys Cys Cys Gly Gly Cys Thr 

            260                 265                 270         





Thr Cys Cys Ala Ala Ala Gly Gly Gly Thr Thr Gly Cys Cys Ala Cys 

        275                 280                 285             





Gly Thr Cys Cys Cys Thr Ala Ala Ala Cys Cys Cys Thr Gly Thr Cys 

    290                 295                 300                 





Thr Cys Cys Ala Gly Cys Thr Cys Gly Cys Ala Thr Ala Cys Ala Cys 

305                 310                 315                 320 





Ala Cys Ala Cys Gly Cys Ala Cys Ala Gly Ala Cys Ala Cys Gly Cys 

                325                 330                 335     





Ala Cys Gly Thr Thr Thr Thr Cys Thr Gly Thr Thr Cys Cys Thr Gly 

            340                 345                 350         





Cys Gly Thr Gly Ala Cys Ala Cys Cys Cys Gly Cys Cys Cys Thr Cys 

        355                 360                 365             





Gly Cys Cys Gly Cys Thr Cys Gly Gly Cys Cys Cys Cys Gly Cys Cys 

    370                 375                 380                 





Gly Gly Thr Cys Cys Cys Cys Gly Cys Gly Cys Gly Gly Thr Gly Cys 

385                 390                 395                 400 





Cys Cys Thr Cys Cys Thr Cys Cys Cys Gly Cys Cys Ala Cys Ala Cys 

                405                 410                 415     





Gly Gly Gly Cys Ala Cys Gly Cys Ala Cys Gly Cys Gly Cys Gly Cys 

            420                 425                 430         





Gly Cys Ala Gly Gly Gly Cys Cys Ala Ala Gly Cys Cys Cys Gly Ala 

        435                 440                 445             





Gly Gly Cys Ala Gly Cys Thr Cys Gly Cys Cys Cys Gly Cys Ala Gly 

    450                 455                 460                 





Cys Thr Cys Gly Cys Ala Cys Thr Cys Gly Cys Ala Gly Gly Cys Gly 

465                 470                 475                 480 





Ala Cys Cys Thr Gly Cys Thr Cys Cys Ala Gly Thr Cys Thr Cys Cys 

                485                 490                 495     





Ala Ala Ala Gly Cys Cys Gly Ala Thr Gly Gly Cys Ala Thr Cys Thr 

            500                 505                 510         





Cys Cys Gly Gly Gly Cys Thr Cys Thr Gly Gly Cys Thr Thr Thr Thr 

        515                 520                 525             





Gly Gly Thr Cys Thr Thr Thr Cys Gly Gly Gly Thr Cys Gly Gly Ala 

    530                 535                 540                 





Ala Gly Ala Thr Gly Gly Cys Thr Cys Thr Gly Gly Gly Gly Ala Thr 

545                 550                 555                 560 





Thr Cys Cys Gly Ala Gly Ala Ala Thr Cys Cys Cys Gly Gly Cys Ala 

                565                 570                 575     





Cys Ala Gly Cys Gly Cys Gly Ala Gly Cys Cys Thr Gly Gly Thr Gly 

            580                 585                 590         





Cys Cys Ala Ala Gly Thr Gly Gly Cys Thr Cys Ala Gly Ala Ala Gly 

        595                 600                 605             





Thr Thr Cys Ala Cys Gly Gly Gly Cys Gly Gly Cys Ala Thr Cys Gly 

    610                 615                 620                 





Gly Ala Ala Ala Cys Ala Ala Ala Cys Thr Gly Thr Gly Cys Gly Cys 

625                 630                 635                 640 





Cys Cys Thr Gly Cys Thr Cys Thr Ala Cys Gly Gly Ala Gly Ala Cys 

                645                 650                 655     





Gly Cys Cys Gly Ala Gly Ala Ala Gly Cys Cys Gly Gly Cys Gly Gly 

            660                 665                 670         





Ala Gly Ala Gly Cys Gly Gly Cys Gly Gly Gly Ala Gly Cys Cys Ala 

        675                 680                 685             





Ala Cys Cys Cys Cys Cys Gly Cys Gly Gly Gly Cys Cys Gly Cys Cys 

    690                 695                 700                 





Gly Cys Cys Cys Gly Gly Ala Ala Gly Gly Cys Cys Gly Cys Cys Thr 

705                 710                 715                 720 





Gly Cys Gly Cys Cys Thr Gly Cys Gly Ala Cys Cys Ala Gly Ala Ala 

                725                 730                 735     





Gly Cys Cys Cys Thr Gly Cys Ala Gly Cys Thr Gly Cys Thr Cys Cys 

            740                 745                 750         





Ala Ala Ala Gly Thr Gly Gly Ala Thr Gly Thr Cys Ala Ala Cys Thr 

        755                 760                 765             





Ala Cys Gly Cys Gly Thr Thr Thr Cys Thr Cys Cys Ala Thr Gly Cys 

    770                 775                 780                 





Ala Ala Cys Ala Gly Ala Cys Cys Thr Gly Cys Thr Gly Cys Cys Gly 

785                 790                 795                 800 





Gly Cys Gly Thr Gly Thr Gly Ala Thr Gly Gly Ala Gly Ala Ala Ala 

                805                 810                 815     





Gly Gly Cys Cys Cys Ala Cys Thr Thr Thr Gly Gly Cys Gly Thr Thr 

            820                 825                 830         





Thr Cys Thr Gly Cys Ala Ala Gly Ala Thr Gly Thr Thr Ala Thr Gly 

        835                 840                 845             





Ala Ala Cys Ala Thr Thr Thr Thr Ala Cys Thr Thr Cys Ala Gly Thr 

    850                 855                 860                 





Ala Thr Gly Thr Gly Gly Thr Gly Ala Ala Ala Ala Gly Thr Thr Thr 

865                 870                 875                 880 





Cys Gly Ala Thr Ala Gly Ala Thr Cys Ala Ala Cys Cys Ala Ala Ala 

                885                 890                 895     





Gly Thr Gly Ala Thr Thr Gly Ala Thr Thr Thr Cys Cys Ala Thr Thr 

            900                 905                 910         





Ala Thr Cys Cys Thr Ala Ala Thr Gly Ala Gly Cys Thr Thr Cys Thr 

        915                 920                 925             





Cys Cys Ala Ala Gly Ala Ala Thr Ala Thr Ala Ala Thr Thr Gly Gly 

    930                 935                 940                 





Gly Ala Ala Thr Thr Gly Gly Cys Ala Gly Ala Cys Cys Ala Ala Cys 

945                 950                 955                 960 





Cys Ala Cys Ala Ala Ala Ala Thr Thr Thr Gly Gly Ala Gly Gly Ala 

                965                 970                 975     





Ala Ala Thr Thr Thr Thr Gly Ala Thr Gly Cys Ala Thr Thr Gly Cys 

            980                 985                 990         





Cys Ala Ala Ala Cys Ala Ala Cys  Thr Cys Thr Ala Ala  Ala Ala Thr 

        995                 1000                 1005             





Ala Thr  Gly Cys Ala Ala Thr  Thr Ala Ala Ala Ala  Cys Ala Gly 

    1010                 1015                 1020             





Gly Gly  Cys Ala Thr Cys Cys  Thr Ala Gly Ala Thr  Ala Cys Thr 

    1025                 1030                 1035             





Thr Cys  Ala Ala Thr Cys Ala  Ala Cys Thr Thr Thr  Cys Thr Ala 

    1040                 1045                 1050             





Cys Thr  Gly Gly Thr Thr Thr  Gly Gly Ala Thr Ala  Thr Gly Gly 

    1055                 1060                 1065             





Thr Thr  Gly Gly Ala Thr Thr  Ala Gly Cys Ala Gly  Cys Ala Gly 

    1070                 1075                 1080             





Ala Cys  Thr Gly Gly Cys Thr  Gly Ala Cys Ala Thr  Cys Ala Ala 

    1085                 1090                 1095             





Cys Ala  Gly Cys Ala Ala Ala  Thr Ala Cys Thr Ala  Ala Cys Ala 

    1100                 1105                 1110             





Thr Gly  Thr Thr Cys Ala Cys  Cys Thr Ala Thr Gly  Ala Ala Ala 

    1115                 1120                 1125             





Thr Thr  Gly Cys Thr Cys Cys  Ala Gly Thr Ala Thr  Thr Thr Gly 

    1130                 1135                 1140             





Thr Gly  Cys Thr Thr Thr Thr  Gly Gly Ala Ala Thr  Ala Thr Gly 

    1145                 1150                 1155             





Thr Cys  Ala Cys Ala Cys Thr  Ala Ala Ala Gly Ala  Ala Ala Ala 

    1160                 1165                 1170             





Thr Gly  Ala Gly Ala Gly Ala  Ala Ala Thr Cys Ala  Thr Thr Gly 

    1175                 1180                 1185             





Gly Cys  Thr Gly Gly Cys Cys  Ala Gly Gly Gly Gly  Gly Cys Thr 

    1190                 1195                 1200             





Cys Thr  Gly Gly Cys Gly Ala  Thr Gly Gly Gly Ala  Thr Ala Thr 

    1205                 1210                 1215             





Thr Thr  Thr Cys Thr Cys Cys  Cys Gly Gly Thr Gly  Gly Cys Gly 

    1220                 1225                 1230             





Cys Cys  Ala Thr Ala Thr Cys  Thr Ala Ala Cys Ala  Thr Gly Thr 

    1235                 1240                 1245             





Ala Thr  Gly Cys Cys Ala Thr  Gly Ala Thr Gly Ala  Thr Cys Gly 

    1250                 1255                 1260             





Cys Ala  Cys Gly Cys Thr Thr  Thr Ala Ala Gly Ala  Thr Gly Thr 

    1265                 1270                 1275             





Thr Cys  Cys Cys Ala Gly Ala  Ala Gly Thr Cys Ala  Ala Gly Gly 

    1280                 1285                 1290             





Ala Gly  Ala Ala Ala Gly Gly  Ala Ala Thr Gly Gly  Cys Thr Gly 

    1295                 1300                 1305             





Cys Thr  Cys Thr Thr Cys Cys  Cys Ala Gly Gly Cys  Thr Cys Ala 

    1310                 1315                 1320             





Thr Thr  Gly Cys Cys Thr Thr  Cys Ala Cys Gly Thr  Cys Thr Gly 

    1325                 1330                 1335             





Ala Ala  Cys Ala Thr Ala Gly  Thr Cys Ala Thr Thr  Thr Thr Thr 

    1340                 1345                 1350             





Cys Thr  Cys Thr Cys Ala Ala  Gly Ala Ala Gly Gly  Gly Ala Gly 

    1355                 1360                 1365             





Cys Thr  Gly Cys Ala Gly Cys  Cys Thr Thr Ala Gly  Gly Gly Ala 

    1370                 1375                 1380             





Thr Thr  Gly Gly Ala Ala Cys  Ala Gly Ala Cys Ala  Gly Cys Gly 

    1385                 1390                 1395             





Thr Gly  Ala Thr Thr Cys Thr  Gly Ala Thr Thr Ala  Ala Ala Thr 

    1400                 1405                 1410             





Gly Thr  Gly Ala Thr Gly Ala  Gly Ala Gly Ala Gly  Gly Gly Ala 

    1415                 1420                 1425             





Ala Ala  Ala Thr Gly Ala Thr  Thr Cys Cys Ala Thr  Cys Thr Gly 

    1430                 1435                 1440             





Ala Thr  Cys Thr Thr Gly Ala  Ala Ala Gly Ala Ala  Gly Gly Ala 

    1445                 1450                 1455             





Thr Thr  Cys Thr Thr Gly Ala  Ala Gly Cys Cys Ala  Ala Ala Cys 

    1460                 1465                 1470             





Ala Gly  Ala Ala Ala Gly Gly  Gly Thr Thr Thr Gly  Thr Thr Cys 

    1475                 1480                 1485             





Cys Thr  Thr Thr Cys Cys Thr  Cys Gly Thr Gly Ala  Gly Thr Gly 

    1490                 1495                 1500             





Cys Cys  Ala Cys Ala Gly Cys  Thr Gly Gly Ala Ala  Cys Cys Ala 

    1505                 1510                 1515             





Cys Cys  Gly Thr Gly Thr Ala  Cys Gly Gly Ala Gly  Cys Ala Thr 

    1520                 1525                 1530             





Thr Thr  Gly Ala Cys Cys Cys  Cys Cys Thr Cys Thr  Thr Ala Gly 

    1535                 1540                 1545             





Cys Thr  Gly Thr Cys Gly Cys  Thr Gly Ala Cys Ala  Thr Thr Thr 

    1550                 1555                 1560             





Gly Cys  Ala Ala Ala Ala Ala  Gly Thr Ala Thr Ala  Ala Gly Ala 

    1565                 1570                 1575             





Thr Cys  Thr Gly Gly Ala Thr  Gly Cys Ala Thr Gly  Thr Gly Gly 

    1580                 1585                 1590             





Ala Thr  Gly Cys Ala Gly Cys  Thr Thr Gly Gly Gly  Gly Thr Gly 

    1595                 1600                 1605             





Gly Gly  Gly Gly Ala Thr Thr  Ala Cys Thr Gly Ala  Thr Gly Thr 

    1610                 1615                 1620             





Cys Cys  Cys Gly Ala Ala Ala  Ala Cys Ala Cys Ala  Ala Gly Thr 

    1625                 1630                 1635             





Gly Gly  Ala Ala Ala Cys Thr  Gly Ala Gly Thr Gly  Gly Cys Gly 

    1640                 1645                 1650             





Thr Gly  Gly Ala Gly Ala Gly  Gly Gly Cys Cys Ala  Ala Cys Thr 

    1655                 1660                 1665             





Cys Thr  Gly Thr Gly Ala Cys  Gly Thr Gly Gly Ala  Ala Thr Cys 

    1670                 1675                 1680             





Cys Ala  Cys Ala Cys Ala Ala  Gly Ala Thr Gly Ala  Thr Gly Gly 

    1685                 1690                 1695             





Gly Ala  Gly Thr Cys Cys Cys  Thr Thr Thr Gly Cys  Ala Gly Thr 

    1700                 1705                 1710             





Gly Cys  Thr Cys Thr Gly Cys  Thr Cys Thr Cys Cys  Thr Gly Gly 

    1715                 1720                 1725             





Thr Thr  Ala Gly Ala Gly Ala  Ala Gly Ala Gly Gly  Gly Ala Thr 

    1730                 1735                 1740             





Thr Gly  Ala Thr Gly Cys Ala  Gly Ala Ala Thr Thr  Gly Cys Ala 

    1745                 1750                 1755             





Ala Cys  Cys Ala Ala Ala Thr  Gly Cys Ala Thr Gly  Cys Cys Thr 

    1760                 1765                 1770             





Cys Cys  Thr Ala Cys Cys Thr  Cys Thr Thr Thr Cys  Ala Gly Cys 

    1775                 1780                 1785             





Ala Ala  Gly Ala Thr Ala Ala  Ala Cys Ala Thr Thr  Ala Thr Gly 

    1790                 1795                 1800             





Ala Cys  Cys Thr Gly Thr Cys  Cys Thr Ala Thr Gly  Ala Cys Ala 

    1805                 1810                 1815             





Cys Thr  Gly Gly Ala Gly Ala  Cys Ala Ala Gly Gly  Cys Cys Thr 

    1820                 1825                 1830             





Thr Ala  Cys Ala Gly Thr Gly  Cys Gly Gly Ala Cys  Gly Cys Cys 

    1835                 1840                 1845             





Ala Cys  Gly Thr Thr Gly Ala  Thr Gly Thr Thr Thr  Thr Thr Ala 

    1850                 1855                 1860             





Ala Ala  Cys Thr Ala Thr Gly  Gly Cys Thr Gly Ala  Thr Gly Thr 

    1865                 1870                 1875             





Gly Gly  Ala Gly Gly Gly Cys  Ala Ala Ala Gly Gly  Gly Gly Ala 

    1880                 1885                 1890             





Cys Thr  Ala Cys Cys Gly Gly  Gly Thr Thr Thr Gly  Ala Ala Gly 

    1895                 1900                 1905             





Cys Gly  Cys Ala Thr Gly Thr  Thr Gly Ala Thr Ala  Ala Ala Thr 

    1910                 1915                 1920             





Gly Thr  Thr Thr Gly Gly Ala  Gly Thr Thr Gly Gly  Cys Ala Gly 

    1925                 1930                 1935             





Ala Gly  Thr Ala Thr Thr Thr  Ala Thr Ala Cys Ala  Ala Cys Ala 

    1940                 1945                 1950             





Thr Cys  Ala Thr Ala Ala Ala  Ala Ala Ala Cys Cys  Gly Ala Gly 

    1955                 1960                 1965             





Ala Ala  Gly Gly Ala Thr Ala  Thr Gly Ala Gly Ala  Thr Gly Gly 

    1970                 1975                 1980             





Thr Gly  Thr Thr Thr Gly Ala  Thr Gly Gly Gly Ala  Ala Gly Cys 

    1985                 1990                 1995             





Cys Thr  Cys Ala Gly Cys Ala  Cys Ala Cys Ala Ala  Ala Thr Gly 

    2000                 2005                 2010             





Thr Cys  Thr Gly Cys Thr Thr  Cys Thr Gly Gly Thr  Ala Cys Ala 

    2015                 2020                 2025             





Thr Thr  Cys Cys Thr Cys Cys  Ala Ala Gly Cys Thr  Thr Gly Cys 

    2030                 2035                 2040             





Gly Thr  Ala Cys Thr Cys Thr  Gly Gly Ala Ala Gly  Ala Cys Ala 

    2045                 2050                 2055             





Ala Thr  Gly Ala Ala Gly Ala  Gly Ala Gly Ala Ala  Thr Gly Ala 

    2060                 2065                 2070             





Gly Thr  Cys Gly Cys Cys Thr  Cys Thr Cys Gly Ala  Ala Gly Gly 

    2075                 2080                 2085             





Thr Gly  Gly Cys Thr Cys Cys  Ala Gly Thr Gly Ala  Thr Thr Ala 

    2090                 2095                 2100             





Ala Ala  Gly Cys Cys Ala Gly  Ala Ala Thr Gly Ala  Thr Gly Gly 

    2105                 2110                 2115             





Ala Gly  Thr Ala Thr Gly Gly  Ala Ala Cys Cys Ala  Cys Ala Ala 

    2120                 2125                 2130             





Thr Gly  Gly Thr Cys Ala Gly  Cys Thr Ala Cys Cys  Ala Ala Cys 

    2135                 2140                 2145             





Cys Cys  Thr Thr Gly Gly Gly  Ala Gly Ala Cys Ala  Ala Gly Gly 

    2150                 2155                 2160             





Thr Cys  Ala Ala Thr Thr Thr  Cys Thr Thr Cys Cys  Gly Cys Ala 

    2165                 2170                 2175             





Thr Gly  Gly Thr Cys Ala Thr  Cys Thr Cys Ala Ala  Ala Cys Cys 

    2180                 2185                 2190             





Cys Ala  Gly Cys Gly Gly Cys  Ala Ala Cys Thr Cys  Ala Cys Cys 

    2195                 2200                 2205             





Ala Ala  Gly Ala Cys Ala Thr  Thr Gly Ala Cys Thr  Thr Cys Cys 

    2210                 2215                 2220             





Thr Gly  Ala Thr Thr Gly Ala  Ala Gly Ala Ala Ala  Thr Ala Gly 

    2225                 2230                 2235             





Ala Ala  Cys Gly Cys Cys Thr  Thr Gly Gly Ala Cys  Ala Ala Gly 

    2240                 2245                 2250             





Ala Thr  Thr Thr Ala Thr Ala  Ala Thr Ala Ala Cys  Cys Thr Thr 

    2255                 2260                 2265             





Gly Cys  Thr Cys Ala Cys Cys  Ala Ala Gly Cys Thr  Gly Thr Thr 

    2270                 2275                 2280             





Cys Cys  Ala Cys Thr Thr Cys  Thr Cys Thr Ala Gly  Ala Gly Ala 

    2285                 2290                 2295             





Ala Cys  Ala Thr Gly Cys Cys  Cys Thr Cys Ala Gly  Cys Thr Ala 

    2300                 2305                 2310             





Ala Gly  Cys Cys Cys Cys Cys  Thr Ala Cys Thr Gly  Ala Gly Ala 

    2315                 2320                 2325             





Ala Ala  Cys Thr Thr Cys Cys  Thr Thr Thr Gly Ala  Gly Ala Ala 

    2330                 2335                 2340             





Thr Thr  Gly Thr Gly Cys Gly  Ala Cys Thr Thr Cys  Ala Cys Ala 

    2345                 2350                 2355             





Ala Ala  Ala Thr Gly Cys Ala  Ala Gly Gly Thr Gly  Ala Ala Cys 

    2360                 2365                 2370             





Ala Cys  Cys Ala Cys Thr Thr  Thr Gly Thr Cys Thr  Cys Thr Gly 

    2375                 2380                 2385             





Ala Gly  Ala Ala Cys Ala Gly  Ala Cys Gly Thr Thr  Ala Cys Cys 

    2390                 2395                 2400             





Ala Ala  Thr Thr Ala Thr Gly  Gly Ala Gly Thr Gly  Thr Cys Ala 

    2405                 2410                 2415             





Cys Cys  Ala Gly Cys Thr Gly  Cys Cys Ala Ala Ala  Ala Thr Cys 

    2420                 2425                 2430             





Gly Thr  Ala Gly Gly Thr Gly  Thr Thr Gly Gly Cys  Thr Cys Thr 

    2435                 2440                 2445             





Gly Cys  Thr Gly Gly Thr Cys  Ala Cys Thr Gly Gly  Ala Gly Thr 

    2450                 2455                 2460             





Ala Gly  Thr Thr Gly Cys Thr  Ala Cys Thr Cys Thr  Thr Cys Ala 

    2465                 2470                 2475             





Gly Ala  Ala Thr Ala Thr Gly  Gly Ala Cys Ala Ala  Ala Gly Ala 

    2480                 2485                 2490             





Ala Gly  Gly Cys Ala Cys Ala  Gly Gly Thr Gly Thr  Ala Ala Ala 

    2495                 2500                 2505             





Thr Ala  Thr Ala Gly Thr Ala  Gly Cys Ala Gly Gly  Ala Thr Gly 

    2510                 2515                 2520             





Ala Gly  Gly Ala Ala Cys Cys  Thr Cys Ala Ala Ala  Cys Thr Gly 

    2525                 2530                 2535             





Gly Gly  Thr Ala Thr Cys Ala  Thr Thr Thr Thr Gly  Cys Ala Cys 

    2540                 2545                 2550             





Gly Thr  Gly Cys Thr Cys Thr  Thr Cys Thr Gly Thr  Thr Cys Thr 

    2555                 2560                 2565             





Cys Ala  Ala Ala Thr Gly Cys  Thr Ala Ala Ala Thr  Gly Cys Ala 

    2570                 2575                 2580             





Ala Ala  Cys Ala Cys Thr Gly  Thr Gly Thr Ala Thr  Thr Thr Ala 

    2585                 2590                 2595             





Thr Thr  Ala Gly Thr Thr Ala  Gly Gly Thr Gly Thr  Gly Cys Cys 

    2600                 2605                 2610             





Ala Ala  Ala Cys Thr Ala Cys  Cys Gly Thr Thr Cys  Cys Cys Ala 

    2615                 2620                 2625             





Ala Ala  Thr Thr Gly Gly Thr  Gly Thr Thr Thr Cys  Thr Gly Ala 

    2630                 2635                 2640             





Ala Thr  Gly Ala Cys Ala Thr  Cys Ala Ala Cys Ala  Thr Thr Cys 

    2645                 2650                 2655             





Cys Cys  Cys Cys Ala Ala Cys  Ala Thr Thr Ala Cys  Thr Cys Cys 

    2660                 2665                 2670             





Ala Thr  Thr Ala Cys Thr Ala  Ala Ala Gly Ala Cys  Ala Gly Ala 

    2675                 2680                 2685             





Ala Ala  Ala Ala Ala Ala Thr  Ala Ala Ala Ala Ala  Cys Ala Thr 

    2690                 2695                 2700             





Ala Ala  Ala Ala Thr Ala Thr  Ala Cys Ala Ala Ala  Cys Ala Thr 

    2705                 2710                 2715             





Gly Thr  Gly Gly Cys Ala Ala  Cys Cys Thr Gly Thr  Thr Cys Thr 

    2720                 2725                 2730             





Thr Cys  Cys Thr Ala Cys Cys  Ala Ala Ala Thr Ala  Thr Ala Ala 

    2735                 2740                 2745             





Ala Cys  Thr Thr Gly Thr Gly  Thr Ala Thr Gly Ala  Thr Cys Cys 

    2750                 2755                 2760             





Ala Ala  Gly Thr Ala Thr Thr  Thr Thr Ala Thr Cys  Thr Gly Thr 

    2765                 2770                 2775             





Gly Thr  Thr Gly Thr Cys Thr  Cys Thr Cys Thr Ala  Ala Ala Cys 

    2780                 2785                 2790             





Cys Cys  Ala Ala Ala Thr Ala  Ala Ala Thr Gly Thr  Gly Thr Ala 

    2795                 2800                 2805             





Ala Ala  Thr Gly Thr Gly Gly  Ala Cys Ala Cys Ala  Thr Cys Thr 

    2810                 2815                 2820             





Cys 

    





<210>  51

<211>  2419

<212>  PRT

<213>  Homo sapiens



<400>  51



Gly Cys Gly Gly Cys Cys Gly Cys Cys Cys Gly Cys Ala Cys Thr Thr 

1               5                   10                  15      





Cys Cys Cys Gly Cys Cys Thr Cys Thr Gly Gly Cys Thr Cys Gly Cys 

            20                  25                  30          





Cys Cys Gly Ala Gly Gly Ala Cys Gly Cys Gly Cys Thr Gly Gly Cys 

        35                  40                  45              





Ala Cys Gly Cys Cys Thr Cys Cys Cys Ala Cys Cys Cys Cys Cys Thr 

    50                  55                  60                  





Cys Ala Cys Thr Cys Thr Gly Ala Cys Thr Cys Cys Ala Gly Cys Thr 

65                  70                  75                  80  





Gly Gly Cys Gly Thr Gly Cys Ala Thr Gly Gly Thr Cys Thr Gly Cys 

                85                  90                  95      





Cys Thr Cys Gly Cys Ala Thr Cys Cys Thr Cys Ala Cys Gly Ala Cys 

            100                 105                 110         





Thr Cys Ala Gly Cys Thr Cys Cys Cys Thr Cys Cys Cys Thr Cys Thr 

        115                 120                 125             





Cys Thr Cys Gly Thr Gly Thr Thr Thr Thr Thr Thr Thr Cys Cys Thr 

    130                 135                 140                 





Cys Cys Gly Cys Cys Gly Cys Cys Cys Cys Cys Thr Cys Ala Thr Thr 

145                 150                 155                 160 





Cys Ala Thr Cys Cys Cys Cys Ala Cys Thr Gly Gly Gly Cys Thr Cys 

                165                 170                 175     





Cys Cys Thr Thr Thr Cys Cys Cys Thr Cys Ala Ala Ala Thr Gly Cys 

            180                 185                 190         





Thr Cys Thr Gly Gly Gly Gly Cys Thr Cys Thr Cys Cys Gly Cys Gly 

        195                 200                 205             





Cys Thr Thr Thr Cys Cys Thr Gly Ala Gly Thr Cys Cys Gly Gly Gly 

    210                 215                 220                 





Cys Thr Cys Cys Gly Ala Gly Gly Ala Cys Cys Cys Thr Thr Ala Gly 

225                 230                 235                 240 





Gly Thr Ala Gly Thr Cys Cys Cys Gly Gly Thr Cys Thr Cys Thr Thr 

                245                 250                 255     





Thr Thr Ala Ala Ala Gly Cys Thr Cys Cys Cys Cys Gly Gly Cys Thr 

            260                 265                 270         





Thr Cys Cys Ala Ala Ala Gly Gly Gly Thr Thr Gly Cys Cys Ala Cys 

        275                 280                 285             





Gly Thr Cys Cys Cys Thr Ala Ala Ala Cys Cys Cys Thr Gly Thr Cys 

    290                 295                 300                 





Thr Cys Cys Ala Gly Cys Thr Cys Gly Cys Ala Thr Ala Cys Ala Cys 

305                 310                 315                 320 





Ala Cys Ala Cys Gly Cys Ala Cys Ala Gly Ala Cys Ala Cys Gly Cys 

                325                 330                 335     





Ala Cys Gly Thr Thr Thr Thr Cys Thr Gly Thr Thr Cys Cys Thr Gly 

            340                 345                 350         





Cys Gly Thr Gly Ala Cys Ala Cys Cys Cys Gly Cys Cys Cys Thr Cys 

        355                 360                 365             





Gly Cys Cys Gly Cys Thr Cys Gly Gly Cys Cys Cys Cys Gly Cys Cys 

    370                 375                 380                 





Gly Gly Thr Cys Cys Cys Cys Gly Cys Gly Cys Gly Gly Thr Gly Cys 

385                 390                 395                 400 





Cys Cys Thr Cys Cys Thr Cys Cys Cys Gly Cys Cys Ala Cys Ala Cys 

                405                 410                 415     





Gly Gly Gly Cys Ala Cys Gly Cys Ala Cys Gly Cys Gly Cys Gly Cys 

            420                 425                 430         





Gly Cys Ala Gly Gly Gly Cys Cys Ala Ala Gly Cys Cys Cys Gly Ala 

        435                 440                 445             





Gly Gly Cys Ala Gly Cys Thr Cys Gly Cys Cys Cys Gly Cys Ala Gly 

    450                 455                 460                 





Cys Thr Cys Gly Cys Ala Cys Thr Cys Gly Cys Ala Gly Gly Cys Gly 

465                 470                 475                 480 





Ala Cys Cys Thr Gly Cys Thr Cys Cys Ala Gly Thr Cys Thr Cys Cys 

                485                 490                 495     





Ala Ala Ala Gly Cys Cys Gly Ala Thr Gly Gly Cys Ala Thr Cys Thr 

            500                 505                 510         





Cys Cys Gly Gly Gly Cys Thr Cys Thr Gly Gly Cys Thr Thr Thr Thr 

        515                 520                 525             





Gly Gly Thr Cys Thr Thr Thr Cys Gly Gly Gly Thr Cys Gly Gly Ala 

    530                 535                 540                 





Ala Gly Ala Thr Gly Gly Cys Thr Cys Thr Gly Gly Gly Gly Ala Thr 

545                 550                 555                 560 





Thr Cys Cys Gly Ala Gly Ala Ala Thr Cys Cys Cys Gly Gly Cys Ala 

                565                 570                 575     





Cys Ala Gly Cys Gly Cys Gly Ala Gly Cys Cys Thr Gly Gly Thr Gly 

            580                 585                 590         





Cys Cys Ala Ala Gly Thr Gly Gly Cys Thr Cys Ala Gly Ala Ala Gly 

        595                 600                 605             





Thr Thr Cys Ala Cys Gly Gly Gly Cys Gly Gly Cys Ala Thr Cys Gly 

    610                 615                 620                 





Gly Ala Ala Ala Cys Ala Ala Ala Cys Thr Gly Thr Gly Cys Gly Cys 

625                 630                 635                 640 





Cys Cys Thr Gly Cys Thr Cys Thr Ala Cys Gly Gly Ala Gly Ala Cys 

                645                 650                 655     





Gly Cys Cys Gly Ala Gly Ala Ala Gly Cys Cys Gly Gly Cys Gly Gly 

            660                 665                 670         





Ala Gly Ala Gly Cys Gly Gly Cys Gly Gly Gly Ala Gly Cys Cys Ala 

        675                 680                 685             





Ala Cys Cys Cys Cys Cys Gly Cys Gly Gly Gly Cys Cys Gly Cys Cys 

    690                 695                 700                 





Gly Cys Cys Cys Gly Gly Ala Ala Gly Gly Cys Cys Gly Cys Cys Thr 

705                 710                 715                 720 





Gly Cys Gly Cys Cys Thr Gly Cys Gly Ala Cys Cys Ala Gly Ala Ala 

                725                 730                 735     





Gly Cys Cys Cys Thr Gly Cys Ala Gly Cys Thr Gly Cys Thr Cys Cys 

            740                 745                 750         





Ala Ala Ala Gly Thr Gly Gly Ala Thr Gly Thr Cys Ala Ala Cys Thr 

        755                 760                 765             





Ala Cys Gly Cys Gly Thr Thr Thr Cys Thr Cys Cys Ala Thr Gly Cys 

    770                 775                 780                 





Ala Ala Cys Ala Gly Ala Cys Cys Thr Gly Cys Thr Gly Cys Cys Gly 

785                 790                 795                 800 





Gly Cys Gly Thr Gly Thr Gly Ala Thr Gly Gly Ala Gly Ala Ala Ala 

                805                 810                 815     





Gly Gly Cys Cys Cys Ala Cys Thr Thr Thr Gly Gly Cys Gly Thr Thr 

            820                 825                 830         





Thr Cys Thr Gly Cys Ala Ala Gly Ala Thr Gly Thr Thr Ala Thr Gly 

        835                 840                 845             





Ala Ala Cys Ala Thr Thr Thr Thr Ala Cys Thr Thr Cys Ala Gly Thr 

    850                 855                 860                 





Ala Thr Gly Thr Gly Gly Thr Gly Ala Ala Ala Ala Gly Thr Thr Thr 

865                 870                 875                 880 





Cys Gly Ala Thr Ala Gly Ala Thr Cys Ala Ala Cys Cys Ala Ala Ala 

                885                 890                 895     





Gly Thr Gly Ala Thr Thr Gly Ala Thr Thr Thr Cys Cys Ala Thr Thr 

            900                 905                 910         





Ala Thr Cys Cys Thr Ala Ala Thr Gly Ala Gly Cys Thr Thr Cys Thr 

        915                 920                 925             





Cys Cys Ala Ala Gly Ala Ala Thr Ala Thr Ala Ala Thr Thr Gly Gly 

    930                 935                 940                 





Gly Ala Ala Thr Thr Gly Gly Cys Ala Gly Ala Cys Cys Ala Ala Cys 

945                 950                 955                 960 





Cys Ala Cys Ala Ala Ala Ala Thr Thr Thr Gly Gly Ala Gly Gly Ala 

                965                 970                 975     





Ala Ala Thr Thr Thr Thr Gly Ala Thr Gly Cys Ala Thr Thr Gly Cys 

            980                 985                 990         





Cys Ala Ala Ala Cys Ala Ala Cys  Thr Cys Thr Ala Ala  Ala Ala Thr 

        995                 1000                 1005             





Ala Thr  Gly Cys Ala Ala Thr  Thr Ala Ala Ala Ala  Cys Ala Gly 

    1010                 1015                 1020             





Gly Gly  Cys Ala Thr Cys Cys  Thr Ala Gly Ala Thr  Ala Cys Thr 

    1025                 1030                 1035             





Thr Cys  Ala Ala Thr Cys Ala  Ala Cys Thr Thr Thr  Cys Thr Ala 

    1040                 1045                 1050             





Cys Thr  Gly Gly Thr Thr Thr  Gly Gly Ala Thr Ala  Thr Gly Gly 

    1055                 1060                 1065             





Thr Thr  Gly Gly Ala Thr Thr  Ala Gly Cys Ala Gly  Cys Ala Gly 

    1070                 1075                 1080             





Ala Cys  Thr Gly Gly Cys Thr  Gly Ala Cys Ala Thr  Cys Ala Ala 

    1085                 1090                 1095             





Cys Ala  Gly Cys Ala Ala Ala  Thr Ala Cys Thr Ala  Ala Cys Ala 

    1100                 1105                 1110             





Thr Gly  Thr Thr Cys Ala Cys  Cys Thr Ala Thr Gly  Ala Ala Ala 

    1115                 1120                 1125             





Thr Thr  Gly Cys Thr Cys Cys  Ala Gly Thr Ala Thr  Thr Thr Gly 

    1130                 1135                 1140             





Thr Gly  Cys Thr Thr Thr Thr  Gly Gly Ala Ala Thr  Ala Thr Gly 

    1145                 1150                 1155             





Thr Cys  Ala Cys Ala Cys Thr  Ala Ala Ala Gly Ala  Ala Ala Ala 

    1160                 1165                 1170             





Thr Gly  Ala Gly Ala Gly Ala  Ala Ala Thr Cys Ala  Thr Thr Gly 

    1175                 1180                 1185             





Gly Cys  Thr Gly Gly Cys Cys  Ala Gly Gly Gly Gly  Gly Cys Thr 

    1190                 1195                 1200             





Cys Thr  Gly Gly Cys Gly Ala  Thr Gly Gly Gly Ala  Thr Ala Thr 

    1205                 1210                 1215             





Thr Thr  Thr Cys Thr Cys Cys  Cys Gly Gly Thr Gly  Gly Cys Gly 

    1220                 1225                 1230             





Cys Cys  Ala Thr Ala Thr Cys  Thr Ala Ala Cys Ala  Thr Gly Thr 

    1235                 1240                 1245             





Ala Thr  Gly Cys Cys Ala Thr  Gly Ala Thr Gly Ala  Thr Cys Gly 

    1250                 1255                 1260             





Cys Ala  Cys Gly Cys Thr Thr  Thr Ala Ala Gly Ala  Thr Gly Thr 

    1265                 1270                 1275             





Thr Cys  Cys Cys Ala Gly Ala  Ala Gly Thr Cys Ala  Ala Gly Gly 

    1280                 1285                 1290             





Ala Gly  Ala Ala Ala Gly Gly  Ala Ala Thr Gly Gly  Cys Thr Gly 

    1295                 1300                 1305             





Cys Thr  Cys Thr Thr Cys Cys  Cys Ala Gly Gly Cys  Thr Cys Ala 

    1310                 1315                 1320             





Thr Thr  Gly Cys Cys Thr Thr  Cys Ala Cys Gly Thr  Cys Thr Gly 

    1325                 1330                 1335             





Ala Ala  Cys Ala Thr Ala Gly  Thr Cys Ala Thr Thr  Thr Thr Thr 

    1340                 1345                 1350             





Cys Thr  Cys Thr Cys Ala Ala  Gly Ala Ala Gly Gly  Gly Ala Gly 

    1355                 1360                 1365             





Cys Thr  Gly Cys Ala Gly Cys  Cys Thr Thr Ala Gly  Gly Gly Ala 

    1370                 1375                 1380             





Thr Thr  Gly Gly Ala Ala Cys  Ala Gly Ala Cys Ala  Gly Cys Gly 

    1385                 1390                 1395             





Thr Gly  Ala Thr Thr Cys Thr  Gly Ala Thr Thr Ala  Ala Ala Thr 

    1400                 1405                 1410             





Gly Thr  Gly Ala Thr Gly Ala  Gly Ala Gly Ala Gly  Gly Gly Ala 

    1415                 1420                 1425             





Ala Ala  Ala Thr Gly Ala Thr  Thr Cys Cys Ala Thr  Cys Thr Gly 

    1430                 1435                 1440             





Ala Thr  Cys Thr Thr Gly Ala  Ala Ala Gly Ala Ala  Gly Gly Ala 

    1445                 1450                 1455             





Thr Thr  Cys Thr Thr Gly Ala  Ala Gly Cys Cys Ala  Ala Ala Cys 

    1460                 1465                 1470             





Ala Gly  Ala Ala Ala Gly Gly  Gly Thr Thr Thr Gly  Thr Thr Cys 

    1475                 1480                 1485             





Cys Thr  Thr Thr Cys Cys Thr  Cys Gly Thr Gly Ala  Gly Thr Gly 

    1490                 1495                 1500             





Cys Cys  Ala Cys Ala Gly Cys  Thr Gly Gly Ala Ala  Cys Cys Ala 

    1505                 1510                 1515             





Cys Cys  Gly Thr Gly Thr Ala  Cys Gly Gly Ala Gly  Cys Ala Thr 

    1520                 1525                 1530             





Thr Thr  Gly Ala Cys Cys Cys  Cys Cys Thr Cys Thr  Thr Ala Gly 

    1535                 1540                 1545             





Cys Thr  Gly Thr Cys Gly Cys  Thr Gly Ala Cys Ala  Thr Thr Thr 

    1550                 1555                 1560             





Gly Cys  Ala Ala Ala Ala Ala  Gly Thr Ala Thr Ala  Ala Gly Ala 

    1565                 1570                 1575             





Thr Cys  Thr Gly Gly Ala Thr  Gly Cys Ala Thr Gly  Thr Gly Gly 

    1580                 1585                 1590             





Ala Thr  Gly Cys Ala Gly Cys  Thr Thr Gly Gly Gly  Gly Thr Gly 

    1595                 1600                 1605             





Gly Gly  Gly Gly Ala Thr Thr  Ala Cys Thr Gly Ala  Thr Gly Thr 

    1610                 1615                 1620             





Cys Cys  Cys Gly Ala Ala Ala  Ala Cys Ala Cys Ala  Ala Gly Thr 

    1625                 1630                 1635             





Gly Gly  Ala Ala Ala Cys Thr  Gly Ala Gly Thr Gly  Gly Cys Gly 

    1640                 1645                 1650             





Thr Gly  Gly Ala Gly Ala Gly  Gly Gly Cys Cys Ala  Ala Cys Thr 

    1655                 1660                 1665             





Cys Thr  Gly Thr Gly Ala Cys  Gly Thr Gly Gly Ala  Ala Thr Cys 

    1670                 1675                 1680             





Cys Ala  Cys Ala Cys Ala Ala  Gly Ala Thr Gly Ala  Thr Gly Gly 

    1685                 1690                 1695             





Gly Ala  Gly Thr Cys Cys Cys  Thr Thr Thr Gly Cys  Ala Gly Thr 

    1700                 1705                 1710             





Gly Cys  Thr Cys Thr Gly Cys  Thr Cys Thr Cys Cys  Thr Gly Gly 

    1715                 1720                 1725             





Thr Thr  Ala Gly Ala Gly Ala  Ala Gly Ala Gly Gly  Gly Ala Thr 

    1730                 1735                 1740             





Thr Gly  Ala Thr Gly Cys Ala  Gly Ala Ala Thr Thr  Gly Cys Ala 

    1745                 1750                 1755             





Ala Cys  Cys Ala Ala Ala Thr  Gly Cys Ala Thr Gly  Cys Cys Thr 

    1760                 1765                 1770             





Cys Cys  Thr Ala Cys Cys Thr  Cys Thr Thr Thr Cys  Ala Gly Cys 

    1775                 1780                 1785             





Ala Ala  Gly Ala Thr Ala Ala  Ala Cys Ala Thr Thr  Ala Thr Gly 

    1790                 1795                 1800             





Ala Cys  Cys Thr Gly Thr Cys  Cys Thr Ala Thr Gly  Ala Cys Ala 

    1805                 1810                 1815             





Cys Thr  Gly Gly Ala Gly Ala  Cys Ala Ala Gly Gly  Cys Cys Thr 

    1820                 1825                 1830             





Thr Ala  Cys Ala Gly Thr Gly  Cys Gly Gly Ala Cys  Gly Cys Cys 

    1835                 1840                 1845             





Ala Cys  Gly Thr Thr Gly Ala  Thr Gly Thr Thr Thr  Thr Thr Ala 

    1850                 1855                 1860             





Ala Ala  Cys Thr Ala Thr Gly  Gly Cys Thr Gly Ala  Thr Gly Thr 

    1865                 1870                 1875             





Gly Gly  Ala Gly Gly Gly Cys  Ala Ala Ala Gly Gly  Gly Gly Ala 

    1880                 1885                 1890             





Cys Thr  Ala Cys Cys Gly Gly  Gly Thr Thr Thr Gly  Ala Ala Gly 

    1895                 1900                 1905             





Cys Gly  Cys Ala Thr Gly Thr  Thr Gly Ala Thr Ala  Ala Ala Thr 

    1910                 1915                 1920             





Gly Thr  Thr Thr Gly Gly Ala  Gly Thr Thr Gly Gly  Cys Ala Gly 

    1925                 1930                 1935             





Ala Gly  Thr Ala Thr Thr Thr  Ala Thr Ala Cys Ala  Ala Cys Ala 

    1940                 1945                 1950             





Thr Cys  Ala Thr Ala Ala Ala  Ala Ala Ala Cys Cys  Gly Ala Gly 

    1955                 1960                 1965             





Ala Ala  Gly Gly Ala Thr Ala  Thr Gly Ala Gly Ala  Thr Gly Gly 

    1970                 1975                 1980             





Thr Gly  Thr Thr Thr Gly Ala  Thr Gly Gly Gly Ala  Ala Gly Cys 

    1985                 1990                 1995             





Cys Thr  Cys Ala Gly Cys Ala  Cys Ala Cys Ala Ala  Ala Thr Gly 

    2000                 2005                 2010             





Thr Cys  Thr Gly Cys Thr Thr  Cys Thr Gly Gly Thr  Ala Cys Ala 

    2015                 2020                 2025             





Thr Thr  Cys Cys Thr Cys Cys  Ala Ala Gly Cys Thr  Thr Gly Cys 

    2030                 2035                 2040             





Gly Thr  Ala Cys Thr Cys Thr  Gly Gly Ala Ala Gly  Ala Cys Ala 

    2045                 2050                 2055             





Ala Thr  Gly Ala Ala Gly Ala  Gly Ala Gly Ala Ala  Thr Gly Ala 

    2060                 2065                 2070             





Gly Thr  Cys Gly Cys Cys Thr  Cys Thr Cys Gly Ala  Ala Gly Gly 

    2075                 2080                 2085             





Thr Gly  Gly Cys Thr Cys Cys  Ala Gly Thr Gly Ala  Thr Thr Ala 

    2090                 2095                 2100             





Ala Ala  Gly Cys Cys Ala Gly  Ala Ala Thr Gly Ala  Thr Gly Gly 

    2105                 2110                 2115             





Ala Gly  Thr Ala Thr Gly Gly  Ala Ala Cys Cys Ala  Cys Ala Ala 

    2120                 2125                 2130             





Thr Gly  Gly Thr Cys Ala Gly  Cys Thr Ala Cys Cys  Ala Ala Cys 

    2135                 2140                 2145             





Cys Cys  Thr Thr Gly Gly Gly  Ala Gly Ala Cys Ala  Ala Gly Gly 

    2150                 2155                 2160             





Thr Cys  Ala Ala Thr Thr Thr  Cys Thr Thr Cys Cys  Gly Cys Ala 

    2165                 2170                 2175             





Thr Gly  Gly Thr Cys Ala Thr  Cys Thr Cys Ala Ala  Ala Cys Cys 

    2180                 2185                 2190             





Cys Ala  Gly Cys Gly Gly Cys  Ala Ala Cys Thr Cys  Ala Cys Cys 

    2195                 2200                 2205             





Ala Ala  Gly Ala Cys Ala Thr  Thr Gly Ala Cys Thr  Thr Cys Cys 

    2210                 2215                 2220             





Thr Gly  Ala Thr Thr Gly Ala  Ala Gly Ala Ala Ala  Thr Ala Gly 

    2225                 2230                 2235             





Ala Ala  Cys Gly Cys Cys Thr  Thr Gly Gly Ala Cys  Ala Ala Gly 

    2240                 2245                 2250             





Ala Thr  Thr Thr Ala Thr Ala  Ala Thr Ala Ala Cys  Cys Thr Thr 

    2255                 2260                 2265             





Gly Cys  Thr Cys Ala Cys Cys  Ala Ala Gly Cys Thr  Gly Thr Thr 

    2270                 2275                 2280             





Cys Cys  Ala Cys Thr Thr Cys  Thr Cys Thr Ala Gly  Gly Thr Ala 

    2285                 2290                 2295             





Gly Ala  Cys Ala Ala Thr Thr  Ala Ala Gly Thr Thr  Gly Thr Cys 

    2300                 2305                 2310             





Ala Cys  Ala Ala Ala Cys Thr  Gly Thr Gly Thr Gly  Ala Ala Thr 

    2315                 2320                 2325             





Gly Thr  Ala Thr Thr Thr Gly  Thr Ala Gly Thr Thr  Thr Gly Thr 

    2330                 2335                 2340             





Thr Cys  Cys Ala Ala Ala Gly  Thr Ala Ala Ala Thr  Cys Thr Ala 

    2345                 2350                 2355             





Thr Thr  Thr Cys Thr Ala Thr  Ala Thr Thr Gly Thr  Gly Gly Thr 

    2360                 2365                 2370             





Gly Thr  Cys Ala Ala Ala Gly  Thr Ala Gly Ala Gly  Thr Thr Thr 

    2375                 2380                 2385             





Ala Ala  Ala Ala Ala Thr Thr  Ala Ala Ala Cys Ala  Ala Ala Ala 

    2390                 2395                 2400             





Ala Ala  Gly Ala Cys Ala Thr  Thr Gly Cys Thr Cys  Cys Thr Thr 

    2405                 2410                 2415             





Thr 

    





<210>  52

<211>  3488

<212>  PRT

<213>  Homo sapiens



<400>  52



Gly Cys Ala Ala Ala Ala Cys Cys Gly Thr Gly Ala Gly Cys Thr Gly 

1               5                   10                  15      





Gly Ala Thr Thr Thr Ala Thr Ala Ala Thr Cys Gly Cys Cys Cys Thr 

            20                  25                  30          





Ala Thr Ala Ala Ala Gly Cys Thr Cys Cys Ala Gly Ala Gly Gly Cys 

        35                  40                  45              





Gly Gly Thr Cys Ala Gly Gly Cys Ala Cys Cys Thr Gly Cys Ala Gly 

    50                  55                  60                  





Ala Gly Gly Ala Gly Cys Cys Cys Cys Gly Cys Cys Gly Cys Thr Cys 

65                  70                  75                  80  





Cys Gly Cys Cys Gly Ala Cys Thr Ala Gly Cys Thr Gly Cys Cys Cys 

                85                  90                  95      





Cys Cys Gly Cys Gly Ala Gly Cys Ala Ala Cys Gly Gly Cys Cys Thr 

            100                 105                 110         





Cys Gly Thr Gly Ala Thr Thr Thr Cys Cys Cys Cys Gly Cys Cys Gly 

        115                 120                 125             





Ala Thr Cys Cys Gly Gly Thr Cys Cys Cys Cys Gly Cys Cys Thr Cys 

    130                 135                 140                 





Cys Cys Cys Ala Cys Thr Cys Thr Gly Cys Cys Cys Cys Cys Gly Cys 

145                 150                 155                 160 





Cys Thr Ala Cys Cys Cys Cys Gly Gly Ala Gly Cys Cys Gly Thr Gly 

                165                 170                 175     





Cys Ala Gly Cys Cys Gly Cys Cys Thr Cys Thr Cys Cys Gly Ala Ala 

            180                 185                 190         





Thr Cys Thr Cys Thr Cys Thr Cys Thr Thr Cys Thr Cys Cys Thr Gly 

        195                 200                 205             





Gly Cys Gly Cys Thr Cys Gly Cys Gly Thr Gly Cys Gly Ala Gly Ala 

    210                 215                 220                 





Gly Gly Gly Ala Ala Cys Thr Ala Gly Cys Gly Ala Gly Ala Ala Cys 

225                 230                 235                 240 





Gly Ala Gly Gly Ala Ala Gly Cys Ala Gly Cys Thr Gly Gly Ala Gly 

                245                 250                 255     





Gly Thr Gly Ala Cys Gly Cys Cys Gly Gly Gly Cys Ala Gly Ala Thr 

            260                 265                 270         





Thr Ala Cys Gly Cys Cys Thr Gly Thr Cys Ala Gly Gly Gly Cys Cys 

        275                 280                 285             





Gly Ala Gly Cys Cys Gly Ala Gly Cys Gly Gly Ala Thr Cys Gly Cys 

    290                 295                 300                 





Thr Gly Gly Gly Cys Gly Cys Thr Gly Thr Gly Cys Ala Gly Ala Gly 

305                 310                 315                 320 





Gly Ala Ala Ala Gly Gly Cys Gly Gly Gly Ala Gly Thr Gly Cys Cys 

                325                 330                 335     





Cys Gly Gly Cys Thr Cys Gly Cys Thr Gly Thr Cys Gly Cys Ala Gly 

            340                 345                 350         





Ala Gly Cys Cys Gly Ala Gly Cys Cys Thr Gly Thr Thr Thr Cys Thr 

        355                 360                 365             





Gly Cys Gly Cys Cys Gly Gly Ala Cys Cys Ala Gly Thr Cys Gly Ala 

    370                 375                 380                 





Gly Gly Ala Cys Thr Cys Thr Gly Gly Ala Cys Ala Gly Thr Ala Gly 

385                 390                 395                 400 





Ala Gly Gly Cys Cys Cys Cys Gly Gly Gly Ala Cys Gly Ala Cys Cys 

                405                 410                 415     





Gly Ala Gly Cys Thr Gly Ala Thr Gly Gly Cys Gly Thr Cys Thr Thr 

            420                 425                 430         





Cys Gly Ala Cys Cys Cys Cys Ala Thr Cys Thr Thr Cys Gly Thr Cys 

        435                 440                 445             





Cys Gly Cys Ala Ala Cys Cys Thr Cys Cys Thr Cys Gly Ala Ala Cys 

    450                 455                 460                 





Gly Cys Gly Gly Gly Ala Gly Cys Gly Gly Ala Cys Cys Cys Cys Ala 

465                 470                 475                 480 





Ala Thr Ala Cys Cys Ala Cys Thr Ala Ala Cys Cys Thr Gly Cys Gly 

                485                 490                 495     





Cys Cys Cys Cys Ala Cys Ala Ala Cys Gly Thr Ala Cys Gly Ala Thr 

            500                 505                 510         





Ala Cys Cys Thr Gly Gly Thr Gly Cys Gly Gly Cys Gly Thr Gly Gly 

        515                 520                 525             





Cys Cys Cys Ala Thr Gly Gly Ala Thr Gly Cys Ala Cys Cys Ala Gly 

    530                 535                 540                 





Ala Ala Ala Ala Cys Thr Gly Gly Gly Gly Cys Thr Cys Ala Ala Gly 

545                 550                 555                 560 





Ala Thr Cys Thr Gly Cys Gly Gly Cys Thr Thr Cys Thr Thr Gly Cys 

                565                 570                 575     





Ala Ala Ala Gly Gly Ala Cys Cys Ala Ala Cys Ala Gly Cys Cys Thr 

            580                 585                 590         





Gly Gly Ala Ala Gly Ala Gly Ala Ala Gly Ala Gly Thr Cys Gly Cys 

        595                 600                 605             





Cys Thr Thr Gly Thr Gly Ala Gly Thr Gly Cys Cys Thr Thr Cys Ala 

    610                 615                 620                 





Ala Gly Gly Ala Gly Ala Gly Gly Cys Ala Ala Thr Cys Cys Thr Cys 

625                 630                 635                 640 





Cys Ala Ala Gly Ala Ala Cys Cys Thr Gly Cys Thr Thr Thr Cys Cys 

                645                 650                 655     





Thr Gly Thr Gly Ala Ala Ala Ala Cys Ala Gly Cys Gly Ala Cys Cys 

            660                 665                 670         





Gly Gly Gly Ala Thr Gly Cys Cys Cys Gly Cys Thr Thr Cys Cys Gly 

        675                 680                 685             





Gly Cys Gly Cys Ala Cys Ala Gly Ala Gly Ala Cys Thr Gly Ala Cys 

    690                 695                 700                 





Thr Thr Cys Thr Cys Thr Ala Ala Thr Cys Thr Gly Thr Thr Thr Gly 

705                 710                 715                 720 





Cys Thr Ala Gly Ala Gly Ala Thr Cys Thr Gly Cys Thr Thr Cys Cys 

                725                 730                 735     





Gly Gly Cys Thr Ala Ala Gly Ala Ala Cys Gly Gly Thr Gly Ala Gly 

            740                 745                 750         





Gly Ala Gly Cys Ala Ala Ala Cys Cys Gly Thr Gly Cys Ala Ala Thr 

        755                 760                 765             





Thr Cys Cys Thr Cys Cys Thr Gly Gly Ala Ala Gly Thr Gly Gly Thr 

    770                 775                 780                 





Gly Gly Ala Cys Ala Thr Ala Cys Thr Cys Cys Thr Cys Ala Ala Cys 

785                 790                 795                 800 





Thr Ala Thr Gly Thr Cys Cys Gly Cys Ala Ala Gly Ala Cys Ala Thr 

                805                 810                 815     





Thr Thr Gly Ala Thr Cys Gly Cys Thr Cys Cys Ala Cys Cys Ala Ala 

            820                 825                 830         





Gly Gly Thr Gly Cys Thr Gly Gly Ala Cys Thr Thr Thr Cys Ala Thr 

        835                 840                 845             





Cys Ala Cys Cys Cys Ala Cys Ala Cys Cys Ala Gly Thr Thr Gly Cys 

    850                 855                 860                 





Thr Gly Gly Ala Ala Gly Gly Cys Ala Thr Gly Gly Ala Gly Gly Gly 

865                 870                 875                 880 





Cys Thr Thr Cys Ala Ala Cys Thr Thr Gly Gly Ala Gly Cys Thr Cys 

                885                 890                 895     





Thr Cys Thr Gly Ala Cys Cys Ala Cys Cys Cys Cys Gly Ala Gly Thr 

            900                 905                 910         





Cys Cys Cys Thr Gly Gly Ala Gly Cys Ala Gly Ala Thr Cys Cys Thr 

        915                 920                 925             





Gly Gly Thr Thr Gly Ala Cys Thr Gly Cys Ala Gly Ala Gly Ala Cys 

    930                 935                 940                 





Ala Cys Cys Thr Thr Gly Ala Ala Gly Thr Ala Thr Gly Gly Gly Gly 

945                 950                 955                 960 





Thr Thr Cys Gly Cys Ala Cys Ala Gly Gly Thr Cys Ala Thr Cys Cys 

                965                 970                 975     





Thr Cys Gly Ala Thr Thr Thr Thr Thr Cys Ala Ala Cys Cys Ala Gly 

            980                 985                 990         





Cys Thr Cys Thr Cys Cys Ala Cys  Thr Gly Gly Ala Thr  Thr Gly Gly 

        995                 1000                 1005             





Ala Thr  Ala Thr Thr Ala Thr  Thr Gly Gly Cys Cys  Thr Ala Gly 

    1010                 1015                 1020             





Cys Thr  Gly Gly Ala Gly Ala  Ala Thr Gly Gly Cys  Thr Gly Ala 

    1025                 1030                 1035             





Cys Ala  Thr Cys Ala Ala Cys  Gly Gly Cys Cys Ala  Ala Thr Ala 

    1040                 1045                 1050             





Cys Cys  Ala Ala Cys Ala Thr  Gly Thr Thr Thr Ala  Cys Ala Thr 

    1055                 1060                 1065             





Ala Thr  Gly Ala Ala Ala Thr  Thr Gly Cys Ala Cys  Cys Ala Gly 

    1070                 1075                 1080             





Thr Gly  Thr Thr Thr Gly Thr  Cys Cys Thr Cys Ala  Thr Gly Gly 

    1085                 1090                 1095             





Ala Ala  Cys Ala Ala Ala Thr  Ala Ala Cys Ala Cys  Thr Thr Ala 

    1100                 1105                 1110             





Ala Gly  Ala Ala Gly Ala Thr  Gly Ala Gly Ala Gly  Ala Gly Ala 

    1115                 1120                 1125             





Thr Ala  Gly Thr Thr Gly Gly  Ala Thr Gly Gly Thr  Cys Ala Ala 

    1130                 1135                 1140             





Gly Thr  Ala Ala Ala Gly Ala  Thr Gly Gly Thr Gly  Ala Thr Gly 

    1145                 1150                 1155             





Gly Gly  Ala Thr Ala Thr Thr  Thr Thr Cys Thr Cys  Cys Thr Gly 

    1160                 1165                 1170             





Gly Gly  Gly Gly Cys Gly Cys  Cys Ala Thr Ala Thr  Cys Cys Ala 

    1175                 1180                 1185             





Ala Cys  Ala Thr Gly Thr Ala  Cys Ala Gly Cys Ala  Thr Cys Ala 

    1190                 1195                 1200             





Thr Gly  Gly Cys Thr Gly Cys  Thr Cys Gly Cys Thr  Ala Cys Ala 

    1205                 1210                 1215             





Ala Gly  Thr Ala Cys Thr Thr  Cys Cys Cys Gly Gly  Ala Ala Gly 

    1220                 1225                 1230             





Thr Thr  Ala Ala Gly Ala Cys  Ala Ala Ala Gly Gly  Gly Cys Ala 

    1235                 1240                 1245             





Thr Gly  Gly Cys Gly Gly Cys  Thr Gly Thr Gly Cys  Cys Thr Ala 

    1250                 1255                 1260             





Ala Ala  Cys Thr Gly Gly Thr  Cys Cys Thr Cys Thr  Thr Cys Ala 

    1265                 1270                 1275             





Cys Cys  Thr Cys Ala Gly Ala  Ala Cys Ala Gly Ala  Gly Thr Cys 

    1280                 1285                 1290             





Ala Cys  Thr Ala Thr Thr Cys  Cys Ala Thr Ala Ala  Ala Gly Ala 

    1295                 1300                 1305             





Ala Ala  Gly Cys Thr Gly Gly  Gly Gly Cys Thr Gly  Cys Ala Cys 

    1310                 1315                 1320             





Thr Thr  Gly Gly Cys Thr Thr  Thr Gly Gly Ala Ala  Cys Thr Gly 

    1325                 1330                 1335             





Ala Cys  Ala Ala Thr Gly Thr  Gly Ala Thr Thr Thr  Thr Gly Ala 

    1340                 1345                 1350             





Thr Ala  Ala Ala Gly Thr Gly  Cys Ala Ala Thr Gly  Ala Ala Ala 

    1355                 1360                 1365             





Gly Gly  Gly Gly Gly Ala Ala  Ala Ala Thr Ala Ala  Thr Thr Cys 

    1370                 1375                 1380             





Cys Ala  Gly Cys Thr Gly Ala  Thr Thr Thr Thr Gly  Ala Gly Gly 

    1385                 1390                 1395             





Cys Ala  Ala Ala Ala Ala Thr  Thr Cys Thr Thr Gly  Ala Ala Gly 

    1400                 1405                 1410             





Cys Cys  Ala Ala Ala Cys Ala  Gly Ala Ala Gly Gly  Gly Ala Thr 

    1415                 1420                 1425             





Ala Thr  Gly Thr Thr Cys Cys  Cys Thr Thr Thr Thr  Ala Thr Gly 

    1430                 1435                 1440             





Thr Cys  Ala Ala Thr Gly Cys  Ala Ala Cys Thr Gly  Cys Thr Gly 

    1445                 1450                 1455             





Gly Cys  Ala Cys Gly Ala Cys  Thr Gly Thr Thr Thr  Ala Thr Gly 

    1460                 1465                 1470             





Gly Ala  Gly Cys Thr Thr Thr  Thr Gly Ala Thr Cys  Cys Gly Ala 

    1475                 1480                 1485             





Thr Ala  Cys Ala Ala Gly Ala  Gly Ala Thr Thr Gly  Cys Ala Gly 

    1490                 1495                 1500             





Ala Thr  Ala Thr Ala Thr Gly  Thr Gly Ala Gly Ala  Ala Ala Thr 

    1505                 1510                 1515             





Ala Thr  Ala Ala Cys Cys Thr  Thr Thr Gly Gly Thr  Thr Gly Cys 

    1520                 1525                 1530             





Ala Thr  Gly Thr Cys Gly Ala  Thr Gly Cys Thr Gly  Cys Cys Thr 

    1535                 1540                 1545             





Gly Gly  Gly Gly Ala Gly Gly  Thr Gly Gly Gly Cys  Thr Gly Cys 

    1550                 1555                 1560             





Thr Cys  Ala Thr Gly Thr Cys  Cys Ala Gly Gly Ala  Ala Gly Cys 

    1565                 1570                 1575             





Ala Cys  Cys Gly Cys Cys Ala  Thr Ala Ala Ala Cys  Thr Cys Ala 

    1580                 1585                 1590             





Ala Cys  Gly Gly Cys Ala Thr  Ala Gly Ala Ala Ala  Gly Gly Gly 

    1595                 1600                 1605             





Cys Cys  Ala Ala Cys Thr Cys  Ala Gly Thr Cys Ala  Cys Cys Thr 

    1610                 1615                 1620             





Gly Gly  Ala Ala Cys Cys Cys  Thr Cys Ala Cys Ala  Ala Gly Ala 

    1625                 1630                 1635             





Thr Gly  Ala Thr Gly Gly Gly  Cys Gly Thr Gly Cys  Thr Gly Thr 

    1640                 1645                 1650             





Thr Gly  Cys Ala Gly Thr Gly  Cys Thr Cys Thr Gly  Cys Cys Ala 

    1655                 1660                 1665             





Thr Thr  Cys Thr Cys Gly Thr  Cys Ala Ala Gly Gly  Ala Ala Ala 

    1670                 1675                 1680             





Ala Gly  Gly Gly Thr Ala Thr  Ala Cys Thr Cys Cys  Ala Ala Gly 

    1685                 1690                 1695             





Gly Ala  Thr Gly Cys Ala Ala  Cys Cys Ala Gly Ala  Thr Gly Thr 

    1700                 1705                 1710             





Gly Thr  Gly Cys Ala Gly Gly  Ala Thr Ala Cys Cys  Thr Cys Thr 

    1715                 1720                 1725             





Thr Cys  Cys Ala Gly Cys Cys  Ala Gly Ala Cys Ala  Ala Gly Cys 

    1730                 1735                 1740             





Ala Gly  Thr Ala Thr Gly Ala  Thr Gly Thr Cys Thr  Cys Cys Thr 

    1745                 1750                 1755             





Ala Cys  Gly Ala Cys Ala Cys  Cys Gly Gly Gly Gly  Ala Cys Ala 

    1760                 1765                 1770             





Ala Gly  Gly Cys Ala Ala Thr  Thr Cys Ala Gly Thr  Gly Thr Gly 

    1775                 1780                 1785             





Gly Cys  Cys Gly Cys Cys Ala  Cys Gly Thr Gly Gly  Ala Thr Ala 

    1790                 1795                 1800             





Thr Cys  Thr Thr Cys Ala Ala  Gly Thr Thr Cys Thr  Gly Gly Cys 

    1805                 1810                 1815             





Thr Gly  Ala Thr Gly Thr Gly  Gly Ala Ala Ala Gly  Cys Ala Ala 

    1820                 1825                 1830             





Ala Gly  Gly Gly Cys Ala Cys  Ala Gly Thr Gly Gly  Gly Ala Thr 

    1835                 1840                 1845             





Thr Thr  Gly Ala Ala Ala Ala  Cys Cys Ala Gly Ala  Thr Cys Ala 

    1850                 1855                 1860             





Ala Cys  Ala Ala Ala Thr Gly  Cys Cys Thr Gly Gly  Ala Ala Cys 

    1865                 1870                 1875             





Thr Gly  Gly Cys Thr Gly Ala  Ala Thr Ala Cys Cys  Thr Cys Thr 

    1880                 1885                 1890             





Ala Thr  Gly Cys Cys Ala Ala  Gly Ala Thr Thr Ala  Ala Ala Ala 

    1895                 1900                 1905             





Ala Cys  Ala Gly Ala Gly Ala  Ala Gly Ala Ala Thr  Thr Thr Gly 

    1910                 1915                 1920             





Ala Gly  Ala Thr Gly Gly Thr  Thr Thr Thr Cys Ala  Ala Thr Gly 

    1925                 1930                 1935             





Gly Cys  Gly Ala Gly Cys Cys  Thr Gly Ala Gly Cys  Ala Cys Ala 

    1940                 1945                 1950             





Cys Ala  Ala Ala Cys Gly Thr  Cys Thr Gly Thr Thr  Thr Thr Thr 

    1955                 1960                 1965             





Gly Gly  Thr Ala Thr Ala Thr  Thr Cys Cys Ala Cys  Ala Ala Ala 

    1970                 1975                 1980             





Gly Cys  Cys Thr Cys Ala Gly  Gly Gly Gly Thr Gly  Thr Gly Cys 

    1985                 1990                 1995             





Cys Ala  Gly Ala Cys Ala Gly  Cys Cys Cys Thr Cys  Ala Ala Cys 

    2000                 2005                 2010             





Gly Ala  Cys Gly Gly Gly Ala  Ala Ala Ala Gly Cys  Thr Ala Cys 

    2015                 2020                 2025             





Ala Cys  Ala Ala Gly Gly Thr  Gly Gly Cys Thr Cys  Cys Ala Ala 

    2030                 2035                 2040             





Ala Ala  Ala Thr Cys Ala Ala  Ala Gly Cys Cys Cys  Thr Gly Ala 

    2045                 2050                 2055             





Thr Gly  Ala Thr Gly Gly Ala  Gly Thr Cys Ala Gly  Gly Thr Ala 

    2060                 2065                 2070             





Cys Gly  Ala Cys Cys Ala Thr  Gly Gly Thr Thr Gly  Gly Cys Thr 

    2075                 2080                 2085             





Ala Cys  Cys Ala Gly Cys Cys  Cys Cys Ala Ala Gly  Gly Gly Gly 

    2090                 2095                 2100             





Ala Cys  Ala Ala Gly Gly Cys  Cys Ala Ala Cys Thr  Thr Cys Thr 

    2105                 2110                 2115             





Thr Cys  Cys Gly Gly Ala Thr  Gly Gly Thr Cys Ala  Thr Cys Thr 

    2120                 2125                 2130             





Cys Cys  Ala Ala Cys Cys Cys  Ala Gly Cys Cys Gly  Cys Thr Ala 

    2135                 2140                 2145             





Cys Cys  Cys Ala Gly Thr Cys  Thr Gly Ala Cys Ala  Thr Thr Gly 

    2150                 2155                 2160             





Ala Cys  Thr Thr Cys Cys Thr  Cys Ala Thr Thr Gly  Ala Gly Gly 

    2165                 2170                 2175             





Ala Gly  Ala Thr Ala Gly Ala  Ala Ala Gly Ala Cys  Thr Gly Gly 

    2180                 2185                 2190             





Gly Cys  Cys Ala Gly Gly Ala  Thr Cys Thr Gly Thr  Ala Ala Thr 

    2195                 2200                 2205             





Cys Ala  Thr Cys Cys Thr Thr  Cys Gly Cys Ala Gly  Ala Ala Cys 

    2210                 2215                 2220             





Ala Thr  Gly Ala Gly Thr Thr  Thr Ala Thr Gly Gly  Gly Ala Ala 

    2225                 2230                 2235             





Thr Gly  Cys Cys Thr Thr Thr  Thr Cys Cys Cys Thr  Cys Thr Gly 

    2240                 2245                 2250             





Gly Cys  Ala Cys Thr Cys Cys  Ala Gly Ala Ala Cys  Ala Ala Ala 

    2255                 2260                 2265             





Cys Cys  Thr Cys Thr Ala Thr  Ala Thr Gly Thr Thr  Gly Cys Thr 

    2270                 2275                 2280             





Gly Ala  Ala Ala Cys Ala Cys  Ala Cys Ala Gly Gly  Cys Cys Ala 

    2285                 2290                 2295             





Thr Thr  Thr Cys Ala Thr Thr  Gly Ala Gly Gly Gly  Ala Ala Ala 

    2300                 2305                 2310             





Ala Cys  Ala Thr Ala Ala Thr  Ala Thr Cys Thr Thr  Gly Ala Ala 

    2315                 2320                 2325             





Gly Ala  Ala Thr Ala Thr Thr  Gly Thr Thr Ala Ala  Ala Ala Cys 

    2330                 2335                 2340             





Cys Thr  Thr Ala Cys Thr Thr  Ala Ala Ala Gly Cys  Thr Thr Gly 

    2345                 2350                 2355             





Thr Thr  Thr Gly Thr Thr Cys  Thr Ala Gly Thr Thr  Ala Gly Cys 

    2360                 2365                 2370             





Ala Gly  Gly Ala Ala Ala Thr  Ala Gly Thr Gly Thr  Thr Cys Thr 

    2375                 2380                 2385             





Thr Thr  Thr Thr Ala Ala Ala  Ala Ala Gly Thr Thr  Gly Cys Ala 

    2390                 2395                 2400             





Cys Ala  Thr Thr Ala Gly Gly  Ala Ala Cys Ala Gly  Ala Gly Thr 

    2405                 2410                 2415             





Ala Thr  Ala Thr Ala Thr Gly  Thr Ala Cys Ala Gly  Thr Thr Ala 

    2420                 2425                 2430             





Thr Ala  Cys Ala Thr Ala Cys  Cys Thr Cys Thr Cys  Thr Cys Thr 

    2435                 2440                 2445             





Ala Thr  Ala Thr Ala Thr Ala  Cys Ala Thr Gly Thr  Ala Thr Ala 

    2450                 2455                 2460             





Gly Thr  Gly Ala Gly Thr Gly  Thr Gly Gly Cys Thr  Thr Ala Gly 

    2465                 2470                 2475             





Thr Ala  Ala Thr Ala Gly Ala  Thr Cys Ala Cys Gly  Gly Cys Ala 

    2480                 2485                 2490             





Thr Gly  Thr Thr Thr Cys Cys  Cys Gly Cys Thr Cys  Cys Ala Ala 

    2495                 2500                 2505             





Gly Ala  Gly Ala Ala Thr Thr  Cys Ala Cys Thr Thr  Thr Ala Cys 

    2510                 2515                 2520             





Cys Thr  Thr Cys Ala Gly Cys  Ala Gly Thr Thr Ala  Cys Cys Gly 

    2525                 2530                 2535             





Ala Gly  Gly Ala Gly Cys Thr  Ala Ala Ala Cys Ala  Thr Gly Cys 

    2540                 2545                 2550             





Thr Gly  Cys Cys Ala Ala Cys  Cys Ala Gly Cys Thr  Thr Gly Thr 

    2555                 2560                 2565             





Cys Cys  Ala Ala Cys Ala Ala  Cys Thr Cys Cys Ala  Gly Gly Ala 

    2570                 2575                 2580             





Ala Ala  Ala Cys Thr Gly Thr  Thr Thr Thr Thr Cys  Ala Ala Ala 

    2585                 2590                 2595             





Ala Cys  Gly Cys Cys Ala Thr  Gly Thr Cys Cys Thr  Ala Gly Gly 

    2600                 2605                 2610             





Gly Gly  Cys Cys Ala Ala Gly  Gly Gly Ala Ala Ala  Thr Gly Cys 

    2615                 2620                 2625             





Thr Gly  Thr Thr Gly Gly Thr  Gly Ala Gly Ala Ala  Thr Cys Gly 

    2630                 2635                 2640             





Ala Cys  Cys Thr Cys Ala Cys  Thr Gly Thr Cys Ala  Gly Cys Gly 

    2645                 2650                 2655             





Thr Thr  Thr Cys Thr Cys Cys  Ala Cys Cys Thr Gly  Ala Ala Gly 

    2660                 2665                 2670             





Thr Gly  Ala Thr Gly Ala Thr  Gly Gly Ala Thr Gly  Ala Gly Ala 

    2675                 2680                 2685             





Ala Ala  Ala Ala Ala Cys Ala  Cys Cys Ala Cys Cys  Ala Ala Ala 

    2690                 2695                 2700             





Thr Gly  Ala Cys Ala Ala Gly  Thr Cys Ala Cys Ala  Cys Cys Cys 

    2705                 2710                 2715             





Thr Cys  Cys Cys Cys Ala Thr  Thr Ala Gly Thr Ala  Thr Cys Cys 

    2720                 2725                 2730             





Thr Gly  Thr Thr Ala Gly Gly  Gly Gly Ala Ala Ala  Ala Thr Ala 

    2735                 2740                 2745             





Gly Thr  Ala Gly Cys Ala Gly  Ala Gly Thr Cys Ala  Thr Thr Gly 

    2750                 2755                 2760             





Thr Thr  Ala Cys Ala Gly Gly  Thr Gly Thr Ala Cys  Thr Ala Thr 

    2765                 2770                 2775             





Gly Gly  Cys Thr Gly Thr Ala  Thr Thr Thr Thr Thr  Ala Gly Ala 

    2780                 2785                 2790             





Gly Ala  Thr Thr Ala Ala Thr  Thr Thr Gly Thr Gly  Thr Ala Gly 

    2795                 2800                 2805             





Ala Thr  Thr Gly Thr Gly Thr  Ala Ala Ala Thr Thr  Cys Cys Thr 

    2810                 2815                 2820             





Gly Thr  Thr Gly Thr Cys Thr  Gly Ala Cys Cys Thr  Thr Gly Gly 

    2825                 2830                 2835             





Thr Gly  Gly Thr Gly Gly Gly  Ala Gly Gly Gly Gly  Gly Ala Gly 

    2840                 2845                 2850             





Ala Cys  Thr Ala Thr Gly Thr  Gly Thr Cys Ala Thr  Gly Ala Thr 

    2855                 2860                 2865             





Thr Thr  Cys Ala Ala Thr Gly  Ala Thr Thr Gly Thr  Thr Thr Ala 

    2870                 2875                 2880             





Ala Thr  Thr Gly Thr Ala Gly  Gly Thr Cys Ala Ala  Thr Gly Ala 

    2885                 2890                 2895             





Ala Ala  Thr Ala Thr Thr Thr  Gly Cys Thr Thr Ala  Thr Thr Thr 

    2900                 2905                 2910             





Ala Thr  Ala Thr Thr Cys Ala  Gly Ala Gly Ala Thr  Gly Thr Ala 

    2915                 2920                 2925             





Cys Cys  Ala Thr Gly Thr Thr  Ala Ala Ala Gly Ala  Gly Gly Cys 

    2930                 2935                 2940             





Gly Thr  Cys Thr Thr Gly Thr  Ala Thr Thr Thr Thr  Cys Thr Thr 

    2945                 2950                 2955             





Cys Cys  Cys Ala Thr Thr Thr  Gly Thr Ala Ala Thr  Gly Thr Ala 

    2960                 2965                 2970             





Thr Cys  Thr Thr Ala Thr Thr  Thr Ala Thr Ala Thr  Ala Thr Gly 

    2975                 2980                 2985             





Ala Ala  Gly Thr Ala Ala Gly  Thr Thr Cys Thr Gly  Ala Ala Ala 

    2990                 2995                 3000             





Ala Cys  Thr Gly Thr Thr Thr  Ala Thr Gly Gly Thr  Ala Thr Thr 

    3005                 3010                 3015             





Thr Thr  Cys Gly Thr Gly Cys  Ala Thr Thr Thr Gly  Thr Gly Ala 

    3020                 3025                 3030             





Gly Cys  Cys Ala Ala Ala Gly  Ala Gly Ala Ala Ala  Ala Gly Ala 

    3035                 3040                 3045             





Thr Thr  Ala Ala Ala Ala Thr  Thr Ala Gly Thr Gly  Ala Gly Ala 

    3050                 3055                 3060             





Thr Thr  Thr Gly Thr Ala Thr  Thr Thr Ala Thr Ala  Thr Thr Ala 

    3065                 3070                 3075             





Gly Ala  Gly Thr Gly Cys Cys  Cys Thr Thr Ala Ala  Ala Ala Thr 

    3080                 3085                 3090             





Ala Ala  Thr Gly Ala Thr Thr  Thr Ala Ala Gly Cys  Ala Thr Thr 

    3095                 3100                 3105             





Thr Thr  Ala Cys Thr Gly Thr  Cys Thr Gly Thr Ala  Ala Gly Ala 

    3110                 3115                 3120             





Gly Ala  Ala Thr Thr Cys Thr  Ala Ala Gly Ala Thr  Thr Gly Thr 

    3125                 3130                 3135             





Ala Cys  Ala Thr Ala Ala Ala  Gly Thr Cys Ala Thr  Ala Thr Ala 

    3140                 3145                 3150             





Thr Ala  Thr Gly Gly Ala Ala  Ala Thr Cys Cys Thr  Gly Thr Thr 

    3155                 3160                 3165             





Ala Cys  Thr Thr Ala Ala Ala  Thr Ala Gly Cys Ala  Thr Cys Thr 

    3170                 3175                 3180             





Gly Cys  Thr Cys Thr Thr Cys  Thr Cys Thr Thr Ala  Cys Gly Cys 

    3185                 3190                 3195             





Thr Cys  Thr Cys Thr Gly Thr  Cys Thr Gly Gly Cys  Thr Gly Thr 

    3200                 3205                 3210             





Ala Cys  Gly Thr Cys Thr Gly  Gly Thr Gly Thr Thr  Cys Thr Cys 

    3215                 3220                 3225             





Ala Ala  Thr Gly Cys Thr Thr  Thr Thr Cys Thr Ala  Gly Cys Ala 

    3230                 3235                 3240             





Ala Cys  Thr Gly Thr Thr Gly  Gly Ala Thr Ala Ala  Thr Ala Ala 

    3245                 3250                 3255             





Cys Thr  Ala Gly Ala Thr Cys  Thr Cys Cys Thr Gly  Thr Ala Ala 

    3260                 3265                 3270             





Thr Thr  Thr Thr Gly Thr Ala  Gly Thr Ala Gly Thr  Thr Gly Ala 

    3275                 3280                 3285             





Thr Gly  Ala Cys Cys Ala Ala  Thr Cys Thr Cys Thr  Gly Thr Gly 

    3290                 3295                 3300             





Ala Cys  Thr Cys Gly Cys Thr  Thr Ala Gly Cys Thr  Gly Ala Ala 

    3305                 3310                 3315             





Ala Cys  Cys Thr Ala Ala Gly  Gly Cys Ala Ala Cys  Ala Thr Thr 

    3320                 3325                 3330             





Thr Cys  Cys Gly Ala Ala Gly  Ala Cys Cys Thr Thr  Cys Thr Gly 

    3335                 3340                 3345             





Ala Ala  Gly Ala Thr Cys Thr  Cys Ala Gly Ala Thr  Ala Ala Ala 

    3350                 3355                 3360             





Gly Thr  Gly Ala Cys Cys Ala  Gly Gly Cys Thr Cys  Ala Cys Ala 

    3365                 3370                 3375             





Ala Cys  Thr Gly Thr Thr Thr  Thr Thr Gly Ala Ala  Gly Ala Ala 

    3380                 3385                 3390             





Gly Gly  Gly Ala Ala Ala Thr  Thr Cys Ala Cys Ala  Cys Thr Gly 

    3395                 3400                 3405             





Thr Gly  Cys Gly Thr Thr Thr  Thr Ala Gly Ala Gly  Thr Ala Thr 

    3410                 3415                 3420             





Gly Cys  Ala Ala Gly Ala Ala  Gly Ala Ala Thr Ala  Thr Ala Ala 

    3425                 3430                 3435             





Ala Thr  Ala Ala Ala Thr Ala  Ala Ala Ala Ala Thr  Ala Thr Thr 

    3440                 3445                 3450             





Cys Thr  Cys Cys Ala Thr Gly  Gly Ala Gly Ala Ala  Thr Thr Thr 

    3455                 3460                 3465             





Gly Ala  Ala Cys Ala Ala Ala  Ala Ala Ala Ala Ala  Ala Ala Ala 

    3470                 3475                 3480             





Ala Ala  Ala Ala Ala 

    3485             





<210>  53

<211>  594

<212>  PRT

<213>  Homo sapiens



<400>  53



Met Ala Ser Ser Thr Pro Ser Ser Ser Ala Thr Ser Ser Asn Ala Gly 

1               5                   10                  15      





Ala Asp Pro Asn Thr Thr Asn Leu Arg Pro Thr Thr Tyr Asp Thr Trp 

            20                  25                  30          





Cys Gly Val Ala His Gly Cys Thr Arg Lys Leu Gly Leu Lys Ile Cys 

        35                  40                  45              





Gly Phe Leu Gln Arg Thr Asn Ser Leu Glu Glu Lys Ser Arg Leu Val 

    50                  55                  60                  





Ser Ala Phe Lys Glu Arg Gln Ser Ser Lys Asn Leu Leu Ser Cys Glu 

65                  70                  75                  80  





Asn Ser Asp Arg Asp Ala Arg Phe Arg Arg Thr Glu Thr Asp Phe Ser 

                85                  90                  95      





Asn Leu Phe Ala Arg Asp Leu Leu Pro Ala Lys Asn Gly Glu Glu Gln 

            100                 105                 110         





Thr Val Gln Phe Leu Leu Glu Val Val Asp Ile Leu Leu Asn Tyr Val 

        115                 120                 125             





Arg Lys Thr Phe Asp Arg Ser Thr Lys Val Leu Asp Phe His His Pro 

    130                 135                 140                 





His Gln Leu Leu Glu Gly Met Glu Gly Phe Asn Leu Glu Leu Ser Asp 

145                 150                 155                 160 





His Pro Glu Ser Leu Glu Gln Ile Leu Val Asp Cys Arg Asp Thr Leu 

                165                 170                 175     





Lys Tyr Gly Val Arg Thr Gly His Pro Arg Phe Phe Asn Gln Leu Ser 

            180                 185                 190         





Thr Gly Leu Asp Ile Ile Gly Leu Ala Gly Glu Trp Leu Thr Ser Thr 

        195                 200                 205             





Ala Asn Thr Asn Met Phe Thr Tyr Glu Ile Ala Pro Val Phe Val Leu 

    210                 215                 220                 





Met Glu Gln Ile Thr Leu Lys Lys Met Arg Glu Ile Val Gly Trp Ser 

225                 230                 235                 240 





Ser Lys Asp Gly Asp Gly Ile Phe Ser Pro Gly Gly Ala Ile Ser Asn 

                245                 250                 255     





Met Tyr Ser Ile Met Ala Ala Arg Tyr Lys Tyr Phe Pro Glu Val Lys 

            260                 265                 270         





Thr Lys Gly Met Ala Ala Val Pro Lys Leu Val Leu Phe Thr Ser Glu 

        275                 280                 285             





Gln Ser His Tyr Ser Ile Lys Lys Ala Gly Ala Ala Leu Gly Phe Gly 

    290                 295                 300                 





Thr Asp Asn Val Ile Leu Ile Lys Cys Asn Glu Arg Gly Lys Ile Ile 

305                 310                 315                 320 





Pro Ala Asp Phe Glu Ala Lys Ile Leu Glu Ala Lys Gln Lys Gly Tyr 

                325                 330                 335     





Val Pro Phe Tyr Val Asn Ala Thr Ala Gly Thr Thr Val Tyr Gly Ala 

            340                 345                 350         





Phe Asp Pro Ile Gln Glu Ile Ala Asp Ile Cys Glu Lys Tyr Asn Leu 

        355                 360                 365             





Trp Leu His Val Asp Ala Ala Trp Gly Gly Gly Leu Leu Met Ser Arg 

    370                 375                 380                 





Lys His Arg His Lys Leu Asn Gly Ile Glu Arg Ala Asn Ser Val Thr 

385                 390                 395                 400 





Trp Asn Pro His Lys Met Met Gly Val Leu Leu Gln Cys Ser Ala Ile 

                405                 410                 415     





Leu Val Lys Glu Lys Gly Ile Leu Gln Gly Cys Asn Gln Met Cys Ala 

            420                 425                 430         





Gly Tyr Leu Phe Gln Pro Asp Lys Gln Tyr Asp Val Ser Tyr Asp Thr 

        435                 440                 445             





Gly Asp Lys Ala Ile Gln Cys Gly Arg His Val Asp Ile Phe Lys Phe 

    450                 455                 460                 





Trp Leu Met Trp Lys Ala Lys Gly Thr Val Gly Phe Glu Asn Gln Ile 

465                 470                 475                 480 





Asn Lys Cys Leu Glu Leu Ala Glu Tyr Leu Tyr Ala Lys Ile Lys Asn 

                485                 490                 495     





Arg Glu Glu Phe Glu Met Val Phe Asn Gly Glu Pro Glu His Thr Asn 

            500                 505                 510         





Val Cys Phe Trp Tyr Ile Pro Gln Ser Leu Arg Gly Val Pro Asp Ser 

        515                 520                 525             





Pro Gln Arg Arg Glu Lys Leu His Lys Val Ala Pro Lys Ile Lys Ala 

    530                 535                 540                 





Leu Met Met Glu Ser Gly Thr Thr Met Val Gly Tyr Gln Pro Gln Gly 

545                 550                 555                 560 





Asp Lys Ala Asn Phe Phe Arg Met Val Ile Ser Asn Pro Ala Ala Thr 

                565                 570                 575     





Gln Ser Asp Ile Asp Phe Leu Ile Glu Glu Ile Glu Arg Leu Gly Gln 

            580                 585                 590         





Asp Leu 

        





<210>  54

<211>  224

<212>  PRT

<213>  Homo sapiens



<400>  54



Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 

1               5                   10                  15      





Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 

            20                  25                  30          





Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 

        35                  40                  45              





Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 

    50                  55                  60                  





Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 

65                  70                  75                  80  





Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 

                85                  90                  95      





Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 

            100                 105                 110         





Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 

        115                 120                 125             





Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 

    130                 135                 140                 





Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 

145                 150                 155                 160 





Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 

                165                 170                 175     





Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 

            180                 185                 190         





Leu His Arg Thr Phe Glu Ser Phe Gly Val Leu Gly Pro Gln Val Lys 

        195                 200                 205             





Glu Pro Lys Lys Thr Gly Gln Phe Leu Glu Glu Leu Arg Asn Pro Phe 

    210                 215                 220                 





<210>  55

<211>  206

<212>  PRT

<213>  Homo sapiens



<400>  55



Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 

1               5                   10                  15      





Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 

            20                  25                  30          





Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 

        35                  40                  45              





Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 

    50                  55                  60                  





Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 

65                  70                  75                  80  





Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 

                85                  90                  95      





Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 

            100                 105                 110         





Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 

        115                 120                 125             





Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 

    130                 135                 140                 





Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 

145                 150                 155                 160 





Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 

                165                 170                 175     





Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 

            180                 185                 190         





Leu His Arg Thr Phe Val Phe His Leu Glu Ala Leu Ser Gly 

        195                 200                 205     





<210>  56

<211>  108

<212>  PRT

<213>  Homo sapiens



<400>  56



Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 

1               5                   10                  15      





Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Asp Pro Phe 

            20                  25                  30          





Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala Val Leu Pro Val 

        35                  40                  45              





Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu Cys Leu Gln Tyr 

    50                  55                  60                  





Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn Leu His Arg Thr 

65                  70                  75                  80  





Phe Glu Ser Phe Gly Val Leu Gly Pro Gln Val Lys Glu Pro Lys Lys 

                85                  90                  95      





Thr Gly Gln Phe Leu Glu Glu Leu Arg Asn Pro Phe 

            100                 105             





<210>  57

<211>  252

<212>  PRT

<213>  Homo sapiens



<400>  57



Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 

1               5                   10                  15      





Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 

            20                  25                  30          





Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 

        35                  40                  45              





Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 

    50                  55                  60                  





Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 

65                  70                  75                  80  





Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 

                85                  90                  95      





Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 

            100                 105                 110         





Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 

        115                 120                 125             





Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 

    130                 135                 140                 





Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 

145                 150                 155                 160 





Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 

                165                 170                 175     





Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 

            180                 185                 190         





Leu His Arg Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys 

        195                 200                 205             





Ile Thr Leu Phe Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu 

    210                 215                 220                 





Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu 

225                 230                 235                 240 





Glu Glu Leu Leu Phe His Leu Glu Ala Leu Ser Gly 

                245                 250         





<210>  58

<211>  247

<212>  PRT

<213>  Homo sapiens



<400>  58



Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 

1               5                   10                  15      





Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 

            20                  25                  30          





Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 

        35                  40                  45              





Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 

    50                  55                  60                  





Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 

65                  70                  75                  80  





Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 

                85                  90                  95      





Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 

            100                 105                 110         





Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 

        115                 120                 125             





Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 

    130                 135                 140                 





Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 

145                 150                 155                 160 





Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 

                165                 170                 175     





Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 

            180                 185                 190         





Leu His Arg Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys 

        195                 200                 205             





Ile Thr Leu Phe Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu 

    210                 215                 220                 





Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu 

225                 230                 235                 240 





Glu Glu Leu Arg Asn Pro Phe 

                245         





<210>  59

<211>  213

<212>  PRT

<213>  Homo sapiens



<400>  59



Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 

1               5                   10                  15      





Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 

            20                  25                  30          





Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 

        35                  40                  45              





Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 

    50                  55                  60                  





Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 

65                  70                  75                  80  





Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 

                85                  90                  95      





Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 

            100                 105                 110         





Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 

        115                 120                 125             





Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 

    130                 135                 140                 





Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 

145                 150                 155                 160 





Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 

                165                 170                 175     





Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 

            180                 185                 190         





Leu His Arg Thr Phe Gly Gln Phe Leu Glu Glu Leu Leu Phe His Leu 

        195                 200                 205             





Glu Ala Leu Ser Gly 

    210             





<210>  60

<211>  229

<212>  PRT

<213>  Homo sapiens



<400>  60



Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 

1               5                   10                  15      





Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 

            20                  25                  30          





Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 

        35                  40                  45              





Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 

    50                  55                  60                  





Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 

65                  70                  75                  80  





Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 

                85                  90                  95      





Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 

            100                 105                 110         





Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 

        115                 120                 125             





Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 

    130                 135                 140                 





Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 

145                 150                 155                 160 





Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 

                165                 170                 175     





Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 

            180                 185                 190         





Leu His Arg Thr Phe Glu Ser Phe Gly Val Leu Gly Pro Gln Val Lys 

        195                 200                 205             





Glu Pro Lys Lys Thr Gly Gln Phe Leu Glu Glu Leu Leu Phe His Leu 

    210                 215                 220                 





Glu Ala Leu Ser Gly 

225                 





<210>  61

<211>  208

<212>  PRT

<213>  Homo sapiens



<400>  61



Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 

1               5                   10                  15      





Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 

            20                  25                  30          





Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 

        35                  40                  45              





Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 

    50                  55                  60                  





Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 

65                  70                  75                  80  





Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 

                85                  90                  95      





Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 

            100                 105                 110         





Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 

        115                 120                 125             





Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 

    130                 135                 140                 





Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 

145                 150                 155                 160 





Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 

                165                 170                 175     





Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 

            180                 185                 190         





Leu His Arg Thr Phe Gly Gln Phe Leu Glu Glu Leu Arg Asn Pro Phe 

        195                 200                 205             





<210>  62

<211>  131

<212>  PRT

<213>  Homo sapiens



<400>  62



Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 

1               5                   10                  15      





Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Asp Pro Phe 

            20                  25                  30          





Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala Val Leu Pro Val 

        35                  40                  45              





Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu Cys Leu Gln Tyr 

    50                  55                  60                  





Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn Leu His Arg Thr 

65                  70                  75                  80  





Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys Ile Thr Leu Phe 

                85                  90                  95      





Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu Ile Ile Cys Tyr 

            100                 105                 110         





Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu Glu Glu Leu Arg 

        115                 120                 125             





Asn Pro Phe 

    130     





<210>  63

<211>  197

<212>  PRT

<213>  Homo sapiens



<400>  63



Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu 

1               5                   10                  15      





Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg 

            20                  25                  30          





His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly 

        35                  40                  45              





Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Val Pro Trp Leu Lys 

    50                  55                  60                  





Pro Gly Arg Ser Pro Leu Pro Ser His Ala Arg Ser Gln Pro Gly Leu 

65                  70                  75                  80  





Cys Asn Met Tyr Lys Asp Ser His His Pro Ala Arg Thr Ala His Tyr 

                85                  90                  95      





Gly Ser Leu Pro Gln Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro 

            100                 105                 110         





Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro 

        115                 120                 125             





Ser Gln Gly Lys Gly Arg Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly 

    130                 135                 140                 





Ala Glu Gly Gln Arg Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp 

145                 150                 155                 160 





Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr 

                165                 170                 175     





Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser 

            180                 185                 190         





Pro Met Ala Arg Arg 

        195         





<210>  64

<211>  171

<212>  PRT

<213>  Homo sapiens



<400>  64



Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu 

1               5                   10                  15      





Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg 

            20                  25                  30          





His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly 

        35                  40                  45              





Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Asp Ser His His Pro 

    50                  55                  60                  





Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln Lys Ser His Gly Arg 

65                  70                  75                  80  





Thr Gln Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr 

                85                  90                  95      





Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly Arg Gly Leu Ser Leu 

            100                 105                 110         





Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg Pro Gly Phe Gly Tyr 

        115                 120                 125             





Gly Gly Arg Ala Ser Asp Tyr Lys Ser Ala His Lys Gly Phe Lys Gly 

    130                 135                 140                 





Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg 

145                 150                 155                 160 





Asp Ser Arg Ser Gly Ser Pro Met Ala Arg Arg 

                165                 170     





<210>  65

<211>  160

<212>  PRT

<213>  Homo sapiens



<400>  65



Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu 

1               5                   10                  15      





Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg 

            20                  25                  30          





His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly 

        35                  40                  45              





Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Asp Ser His His Pro 

    50                  55                  60                  





Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln Lys Ser His Gly Arg 

65                  70                  75                  80  





Thr Gln Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr 

                85                  90                  95      





Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly Ala Glu Gly Gln Arg 

            100                 105                 110         





Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp Tyr Lys Ser Ala His 

        115                 120                 125             





Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe 

    130                 135                 140                 





Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser Pro Met Ala Arg Arg 

145                 150                 155                 160 





<210>  66

<211>  197

<212>  PRT

<213>  Homo sapiens



<400>  66



Met Gly Asn His Ala Gly Lys Arg Glu Leu Asn Ala Glu Lys Ala Ser 

1               5                   10                  15      





Thr Asn Ser Glu Thr Asn Arg Gly Glu Ser Glu Lys Lys Arg Asn Leu 

            20                  25                  30          





Gly Glu Leu Ser Arg Thr Thr Ser Glu Asp Asn Glu Val Phe Gly Glu 

        35                  40                  45              





Ala Asp Ala Asn Gln Asn Asn Gly Thr Ser Ser Gln Asp Thr Ala Val 

    50                  55                  60                  





Thr Asp Ser Lys Arg Thr Ala Asp Pro Lys Asn Ala Trp Gln Asp Ala 

65                  70                  75                  80  





His Pro Ala Asp Pro Gly Ser Arg Pro His Leu Ile Arg Leu Phe Ser 

                85                  90                  95      





Arg Asp Ala Pro Gly Arg Glu Asp Asn Thr Phe Lys Asp Arg Pro Ser 

            100                 105                 110         





Glu Ser Asp Glu Leu Gln Thr Ile Gln Glu Asp Ser Ala Ala Thr Ser 

        115                 120                 125             





Glu Ser Leu Asp Val Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His 

    130                 135                 140                 





Gly Ser Lys Tyr Leu Ala Thr Ala Ser Thr Met Asp His Ala Arg His 

145                 150                 155                 160 





Gly Phe Leu Pro Arg His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly 

                165                 170                 175     





Arg Phe Phe Gly Gly Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys 

            180                 185                 190         





Val Ser Ser Glu Glu 

        195         





<210>  67

<211>  304

<212>  PRT

<213>  Homo sapiens



<400>  67



Met Gly Asn His Ala Gly Lys Arg Glu Leu Asn Ala Glu Lys Ala Ser 

1               5                   10                  15      





Thr Asn Ser Glu Thr Asn Arg Gly Glu Ser Glu Lys Lys Arg Asn Leu 

            20                  25                  30          





Gly Glu Leu Ser Arg Thr Thr Ser Glu Asp Asn Glu Val Phe Gly Glu 

        35                  40                  45              





Ala Asp Ala Asn Gln Asn Asn Gly Thr Ser Ser Gln Asp Thr Ala Val 

    50                  55                  60                  





Thr Asp Ser Lys Arg Thr Ala Asp Pro Lys Asn Ala Trp Gln Asp Ala 

65                  70                  75                  80  





His Pro Ala Asp Pro Gly Ser Arg Pro His Leu Ile Arg Leu Phe Ser 

                85                  90                  95      





Arg Asp Ala Pro Gly Arg Glu Asp Asn Thr Phe Lys Asp Arg Pro Ser 

            100                 105                 110         





Glu Ser Asp Glu Leu Gln Thr Ile Gln Glu Asp Ser Ala Ala Thr Ser 

        115                 120                 125             





Glu Ser Leu Asp Val Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His 

    130                 135                 140                 





Gly Ser Lys Tyr Leu Ala Thr Ala Ser Thr Met Asp His Ala Arg His 

145                 150                 155                 160 





Gly Phe Leu Pro Arg His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly 

                165                 170                 175     





Arg Phe Phe Gly Gly Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys 

            180                 185                 190         





Asp Ser His His Pro Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln 

        195                 200                 205             





Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro Val Val His Phe Phe 

    210                 215                 220                 





Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly 

225                 230                 235                 240 





Arg Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg 

                245                 250                 255     





Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp Tyr Lys Ser Ala His 

            260                 265                 270         





Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe 

        275                 280                 285             





Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser Pro Met Ala Arg Arg 

    290                 295                 300                 





<210>  68

<211>  186

<212>  PRT

<213>  Homo sapiens



<400>  68



Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu 

1               5                   10                  15      





Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg 

            20                  25                  30          





His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly 

        35                  40                  45              





Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Val Pro Trp Leu Lys 

    50                  55                  60                  





Pro Gly Arg Ser Pro Leu Pro Ser His Ala Arg Ser Gln Pro Gly Leu 

65                  70                  75                  80  





Cys Asn Met Tyr Lys Asp Ser His His Pro Ala Arg Thr Ala His Tyr 

                85                  90                  95      





Gly Ser Leu Pro Gln Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro 

            100                 105                 110         





Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro 

        115                 120                 125             





Ser Gln Gly Lys Gly Ala Glu Gly Gln Arg Pro Gly Phe Gly Tyr Gly 

    130                 135                 140                 





Gly Arg Ala Ser Asp Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val 

145                 150                 155                 160 





Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg Asp 

                165                 170                 175     





Ser Arg Ser Gly Ser Pro Met Ala Arg Arg 

            180                 185     





<210>  69

<211>  277

<212>  PRT

<213>  Homo sapiens



<400>  69



Met Gly Leu Leu Glu Cys Cys Ala Arg Cys Leu Val Gly Ala Pro Phe 

1               5                   10                  15      





Ala Ser Leu Val Ala Thr Gly Leu Cys Phe Phe Gly Val Ala Leu Phe 

            20                  25                  30          





Cys Gly Cys Gly His Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu 

        35                  40                  45              





Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile Asn Val 

    50                  55                  60                  





Ile His Ala Phe Gln Tyr Val Ile Tyr Gly Thr Ala Ser Phe Phe Phe 

65                  70                  75                  80  





Leu Tyr Gly Ala Leu Leu Leu Ala Glu Gly Phe Tyr Thr Thr Gly Ala 

                85                  90                  95      





Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys Gly 

            100                 105                 110         





Leu Ser Ala Thr Val Thr Gly Gly Gln Lys Gly Arg Gly Ser Arg Gly 

        115                 120                 125             





Gln His Gln Ala His Ser Leu Glu Arg Val Cys His Cys Leu Gly Lys 

    130                 135                 140                 





Trp Leu Gly His Pro Asp Lys Phe Val Gly Ile Thr Tyr Ala Leu Thr 

145                 150                 155                 160 





Val Val Trp Leu Leu Val Phe Ala Cys Ser Ala Val Pro Val Tyr Ile 

                165                 170                 175     





Tyr Phe Asn Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys 

            180                 185                 190         





Thr Ser Ala Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met Tyr Gly 

        195                 200                 205             





Val Leu Pro Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn Leu 

    210                 215                 220                 





Leu Ser Ile Cys Lys Thr Ala Glu Phe Gln Met Thr Phe His Leu Phe 

225                 230                 235                 240 





Ile Ala Ala Phe Val Gly Ala Ala Ala Thr Leu Val Ser Leu Leu Thr 

                245                 250                 255     





Phe Met Ile Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly 

            260                 265                 270         





Arg Gly Thr Lys Phe 

        275         





<210>  70

<211>  277

<212>  PRT

<213>  Homo sapiens



<400>  70



Met Gly Leu Leu Glu Cys Cys Ala Arg Cys Leu Val Gly Ala Pro Phe 

1               5                   10                  15      





Ala Ser Leu Val Ala Thr Gly Leu Cys Phe Phe Gly Val Ala Leu Phe 

            20                  25                  30          





Cys Gly Cys Gly His Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu 

        35                  40                  45              





Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile Asn Val 

    50                  55                  60                  





Ile His Ala Phe Gln Tyr Val Ile Tyr Gly Thr Ala Ser Phe Phe Phe 

65                  70                  75                  80  





Leu Tyr Gly Ala Leu Leu Leu Ala Glu Gly Phe Tyr Thr Thr Gly Ala 

                85                  90                  95      





Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys Gly 

            100                 105                 110         





Leu Ser Ala Thr Val Thr Gly Gly Gln Lys Gly Arg Gly Ser Arg Gly 

        115                 120                 125             





Gln His Gln Ala His Ser Leu Glu Arg Val Cys His Cys Leu Gly Lys 

    130                 135                 140                 





Trp Leu Gly His Pro Asp Lys Phe Val Gly Ile Thr Tyr Ala Leu Thr 

145                 150                 155                 160 





Val Val Trp Leu Leu Val Phe Ala Cys Ser Ala Val Pro Val Tyr Ile 

                165                 170                 175     





Tyr Phe Asn Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys 

            180                 185                 190         





Thr Ser Ala Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met Tyr Gly 

        195                 200                 205             





Val Leu Pro Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn Leu 

    210                 215                 220                 





Leu Ser Ile Cys Lys Thr Ala Glu Phe Gln Met Thr Phe His Leu Phe 

225                 230                 235                 240 





Ile Ala Ala Phe Val Gly Ala Ala Ala Thr Leu Val Ser Leu Leu Thr 

                245                 250                 255     





Phe Met Ile Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly 

            260                 265                 270         





Arg Gly Thr Lys Phe 

        275         





<210>  71

<211>  242

<212>  PRT

<213>  Homo sapiens



<400>  71



Met Gly Leu Leu Glu Cys Cys Ala Arg Cys Leu Val Gly Ala Pro Phe 

1               5                   10                  15      





Ala Ser Leu Val Ala Thr Gly Leu Cys Phe Phe Gly Val Ala Leu Phe 

            20                  25                  30          





Cys Gly Cys Gly His Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu 

        35                  40                  45              





Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile Asn Val 

    50                  55                  60                  





Ile His Ala Phe Gln Tyr Val Ile Tyr Gly Thr Ala Ser Phe Phe Phe 

65                  70                  75                  80  





Leu Tyr Gly Ala Leu Leu Leu Ala Glu Gly Phe Tyr Thr Thr Gly Ala 

                85                  90                  95      





Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys Gly 

            100                 105                 110         





Leu Ser Ala Thr Phe Val Gly Ile Thr Tyr Ala Leu Thr Val Val Trp 

        115                 120                 125             





Leu Leu Val Phe Ala Cys Ser Ala Val Pro Val Tyr Ile Tyr Phe Asn 

    130                 135                 140                 





Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys Thr Ser Ala 

145                 150                 155                 160 





Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met Tyr Gly Val Leu Pro 

                165                 170                 175     





Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn Leu Leu Ser Ile 

            180                 185                 190         





Cys Lys Thr Ala Glu Phe Gln Met Thr Phe His Leu Phe Ile Ala Ala 

        195                 200                 205             





Phe Val Gly Ala Ala Ala Thr Leu Val Ser Leu Leu Thr Phe Met Ile 

    210                 215                 220                 





Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly Arg Gly Thr 

225                 230                 235                 240 





Lys Phe 

        





<210>  72

<211>  403

<212>  PRT

<213>  Homo sapiens



<400>  72



Met Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu 

1               5                   10                  15      





Thr Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala 

            20                  25                  30          





Gln Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu 

        35                  40                  45              





Thr Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val 

    50                  55                  60                  





Asp His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro 

65                  70                  75                  80  





Leu Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser 

                85                  90                  95      





Phe Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly 

            100                 105                 110         





Gly Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp 

        115                 120                 125             





Ala His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr 

    130                 135                 140                 





Asn Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu 

145                 150                 155                 160 





Ser His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe 

                165                 170                 175     





Ser Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala 

            180                 185                 190         





Ile Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr 

        195                 200                 205             





Pro Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile 

    210                 215                 220                 





Arg Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn 

225                 230                 235                 240 





Pro Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro 

                245                 250                 255     





Gln Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp 

            260                 265                 270         





Glu Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln 

        275                 280                 285             





Asn Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe 

    290                 295                 300                 





Pro Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr 

305                 310                 315                 320 





Gly Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu 

                325                 330                 335     





Tyr Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp 

            340                 345                 350         





Phe Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly 

        355                 360                 365             





Phe Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys 

    370                 375                 380                 





Thr Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys 

385                 390                 395                 400 





Arg Lys Asn 

            





<210>  73

<211>  469

<212>  PRT

<213>  Homo sapiens



<400>  73



Met His Ser Phe Pro Pro Leu Leu Leu Leu Leu Phe Trp Gly Val Val 

1               5                   10                  15      





Ser His Ser Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp 

            20                  25                  30          





Leu Val Gln Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly 

        35                  40                  45              





Arg Gln Val Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu 

    50                  55                  60                  





Lys Gln Met Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp 

65                  70                  75                  80  





Ala Glu Thr Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp 

                85                  90                  95      





Val Ala Gln Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr 

            100                 105                 110         





His Leu Thr Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala 

        115                 120                 125             





Asp Val Asp His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val 

    130                 135                 140                 





Thr Pro Leu Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met 

145                 150                 155                 160 





Ile Ser Phe Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly 

                165                 170                 175     





Pro Gly Gly Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly 

            180                 185                 190         





Gly Asp Ala His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg 

        195                 200                 205             





Glu Tyr Asn Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu 

    210                 215                 220                 





Gly Leu Ser His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr 

225                 230                 235                 240 





Thr Phe Ser Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile 

                245                 250                 255     





Gln Ala Ile Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro 

            260                 265                 270         





Gln Thr Pro Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr 

        275                 280                 285             





Thr Ile Arg Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg 

    290                 295                 300                 





Thr Asn Pro Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe 

305                 310                 315                 320 





Trp Pro Gln Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp 

                325                 330                 335     





Arg Asp Glu Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln 

            340                 345                 350         





Gly Gln Asn Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe 

        355                 360                 365             





Gly Phe Pro Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu 

    370                 375                 380                 





Asn Thr Gly Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr 

385                 390                 395                 400 





Asp Glu Tyr Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala 

                405                 410                 415     





His Asp Phe Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys 

            420                 425                 430         





Asp Gly Phe Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp 

        435                 440                 445             





Pro Lys Thr Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe 

    450                 455                 460                 





Asn Cys Arg Lys Asn 

465                 





<210>  74

<211>  2431

<212>  PRT

<213>  Homo sapiens



<400>  74



Met Thr Thr Leu Leu Trp Val Phe Val Thr Leu Arg Val Ile Thr Ala 

1               5                   10                  15      





Ala Val Thr Val Glu Thr Ser Asp His Asp Asn Ser Leu Ser Val Ser 

            20                  25                  30          





Ile Pro Gln Pro Ser Pro Leu Arg Val Leu Leu Gly Thr Ser Leu Thr 

        35                  40                  45              





Ile Pro Cys Tyr Phe Ile Asp Pro Met His Pro Val Thr Thr Ala Pro 

    50                  55                  60                  





Ser Thr Ala Pro Leu Ala Pro Arg Ile Lys Trp Ser Arg Val Ser Lys 

65                  70                  75                  80  





Glu Lys Glu Val Val Leu Leu Val Ala Thr Glu Gly Arg Val Arg Val 

                85                  90                  95      





Asn Ser Ala Tyr Gln Asp Lys Val Ser Leu Pro Asn Tyr Pro Ala Ile 

            100                 105                 110         





Pro Ser Asp Ala Thr Leu Glu Val Gln Ser Leu Arg Ser Asn Asp Ser 

        115                 120                 125             





Gly Val Tyr Arg Cys Glu Val Met His Gly Ile Glu Asp Ser Glu Ala 

    130                 135                 140                 





Thr Leu Glu Val Val Val Lys Gly Ile Val Phe His Tyr Arg Ala Ile 

145                 150                 155                 160 





Ser Thr Arg Tyr Thr Leu Asp Phe Asp Arg Ala Gln Arg Ala Cys Leu 

                165                 170                 175     





Gln Asn Ser Ala Ile Ile Ala Thr Pro Glu Gln Leu Gln Ala Ala Tyr 

            180                 185                 190         





Glu Asp Gly Phe His Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr 

        195                 200                 205             





Val Arg Tyr Pro Ile His Thr Pro Arg Glu Gly Cys Tyr Gly Asp Lys 

    210                 215                 220                 





Asp Glu Phe Pro Gly Val Arg Thr Tyr Gly Ile Arg Asp Thr Asn Glu 

225                 230                 235                 240 





Thr Tyr Asp Val Tyr Cys Phe Ala Glu Glu Met Glu Gly Glu Val Phe 

                245                 250                 255     





Tyr Ala Thr Ser Pro Glu Lys Phe Thr Phe Gln Glu Ala Ala Asn Glu 

            260                 265                 270         





Cys Arg Arg Leu Gly Ala Arg Leu Ala Thr Thr Gly Gln Leu Tyr Leu 

        275                 280                 285             





Ala Trp Gln Ala Gly Met Asp Met Cys Ser Ala Gly Trp Leu Ala Asp 

    290                 295                 300                 





Arg Ser Val Arg Tyr Pro Ile Ser Lys Ala Arg Pro Asn Cys Gly Gly 

305                 310                 315                 320 





Asn Leu Leu Gly Val Arg Thr Val Tyr Val His Ala Asn Gln Thr Gly 

                325                 330                 335     





Tyr Pro Asp Pro Ser Ser Arg Tyr Asp Ala Ile Cys Tyr Thr Gly Glu 

            340                 345                 350         





Asp Phe Val Asp Ile Pro Glu Asn Phe Phe Gly Val Gly Gly Glu Glu 

        355                 360                 365             





Asp Ile Thr Val Gln Thr Val Thr Trp Pro Asp Met Glu Leu Pro Leu 

    370                 375                 380                 





Pro Arg Asn Ile Thr Glu Gly Glu Ala Arg Gly Ser Val Ile Leu Thr 

385                 390                 395                 400 





Val Lys Pro Ile Phe Glu Val Ser Pro Ser Pro Leu Glu Pro Glu Glu 

                405                 410                 415     





Pro Phe Thr Phe Ala Pro Glu Ile Gly Ala Thr Ala Phe Ala Glu Val 

            420                 425                 430         





Glu Asn Glu Thr Gly Glu Ala Thr Arg Pro Trp Gly Phe Pro Thr Pro 

        435                 440                 445             





Gly Leu Gly Pro Ala Thr Ala Phe Thr Ser Glu Asp Leu Val Val Gln 

    450                 455                 460                 





Val Thr Ala Val Pro Gly Gln Pro His Leu Pro Gly Gly Val Val Phe 

465                 470                 475                 480 





His Tyr Arg Pro Gly Pro Thr Arg Tyr Ser Leu Thr Phe Glu Glu Ala 

                485                 490                 495     





Gln Gln Ala Cys Leu Arg Thr Gly Ala Val Ile Ala Ser Pro Glu Gln 

            500                 505                 510         





Leu Gln Ala Ala Tyr Glu Ala Gly Tyr Glu Gln Cys Asp Ala Gly Trp 

        515                 520                 525             





Leu Arg Asp Gln Thr Val Arg Tyr Pro Ile Val Ser Pro Arg Thr Pro 

    530                 535                 540                 





Cys Val Gly Asp Lys Asp Ser Ser Pro Gly Val Arg Thr Tyr Gly Val 

545                 550                 555                 560 





Arg Pro Ser Thr Glu Thr Tyr Asp Val Tyr Cys Phe Val Asp Arg Leu 

                565                 570                 575     





Glu Gly Glu Val Phe Phe Ala Thr Arg Leu Glu Gln Phe Thr Phe Gln 

            580                 585                 590         





Glu Ala Leu Glu Phe Cys Glu Ser His Asn Ala Thr Leu Ala Thr Thr 

        595                 600                 605             





Gly Gln Leu Tyr Ala Ala Trp Ser Arg Gly Leu Asp Lys Cys Tyr Ala 

    610                 615                 620                 





Gly Trp Leu Ala Asp Gly Ser Leu Arg Tyr Pro Ile Val Thr Pro Arg 

625                 630                 635                 640 





Pro Ala Cys Gly Gly Asp Lys Pro Gly Val Arg Thr Val Tyr Leu Tyr 

                645                 650                 655     





Pro Asn Gln Thr Gly Leu Pro Asp Pro Leu Ser Arg His His Ala Phe 

            660                 665                 670         





Cys Phe Arg Gly Ile Ser Ala Val Pro Ser Pro Gly Glu Glu Glu Gly 

        675                 680                 685             





Gly Thr Pro Thr Ser Pro Ser Gly Val Glu Glu Trp Ile Val Thr Gln 

    690                 695                 700                 





Val Val Pro Gly Val Ala Ala Val Pro Val Glu Glu Glu Thr Thr Ala 

705                 710                 715                 720 





Val Pro Ser Gly Glu Thr Thr Ala Ile Leu Glu Phe Thr Thr Glu Pro 

                725                 730                 735     





Glu Asn Gln Thr Glu Trp Glu Pro Ala Tyr Thr Pro Val Gly Thr Ser 

            740                 745                 750         





Pro Leu Pro Gly Ile Leu Pro Thr Trp Pro Pro Thr Gly Ala Ala Thr 

        755                 760                 765             





Glu Glu Ser Thr Glu Gly Pro Ser Ala Thr Glu Val Pro Ser Ala Ser 

    770                 775                 780                 





Glu Glu Pro Ser Pro Ser Glu Val Pro Phe Pro Ser Glu Glu Pro Ser 

785                 790                 795                 800 





Pro Ser Glu Glu Pro Phe Pro Ser Val Arg Pro Phe Pro Ser Val Glu 

                805                 810                 815     





Leu Phe Pro Ser Glu Glu Pro Phe Pro Ser Lys Glu Pro Ser Pro Ser 

            820                 825                 830         





Glu Glu Pro Ser Ala Ser Glu Glu Pro Tyr Thr Pro Ser Pro Pro Val 

        835                 840                 845             





Pro Ser Trp Thr Glu Leu Pro Ser Ser Gly Glu Glu Ser Gly Ala Pro 

    850                 855                 860                 





Asp Val Ser Gly Asp Phe Thr Gly Ser Gly Asp Val Ser Gly His Leu 

865                 870                 875                 880 





Asp Phe Ser Gly Gln Leu Ser Gly Asp Arg Ala Ser Gly Leu Pro Ser 

                885                 890                 895     





Gly Asp Leu Asp Ser Ser Gly Leu Thr Ser Thr Val Gly Ser Gly Leu 

            900                 905                 910         





Pro Val Glu Ser Gly Leu Pro Ser Gly Asp Glu Glu Arg Ile Glu Trp 

        915                 920                 925             





Pro Ser Thr Pro Thr Val Gly Glu Leu Pro Ser Gly Ala Glu Ile Leu 

    930                 935                 940                 





Glu Gly Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu Pro Ser Gly 

945                 950                 955                 960 





Glu Val Leu Glu Thr Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu 

                965                 970                 975     





Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val Glu Asp Ile 

            980                 985                 990         





Ser Gly Leu Pro Ser Gly Glu Val  Leu Glu Thr Thr Ala  Pro Gly Val 

        995                 1000                 1005             





Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu Val Leu  Glu Thr Thr 

    1010                 1015                 1020             





Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val 

    1025                 1030                 1035             





Leu Glu  Thr Thr Ala Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro 

    1040                 1045                 1050             





Ser Gly  Glu Val Leu Glu Thr  Thr Ala Pro Gly Val  Glu Asp Ile 

    1055                 1060                 1065             





Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu Thr Thr  Ala Pro Gly 

    1070                 1075                 1080             





Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr 

    1085                 1090                 1095             





Ala Ala  Pro Gly Val Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu 

    1100                 1105                 1110             





Val Leu  Glu Thr Ala Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu 

    1115                 1120                 1125             





Pro Ser  Gly Glu Val Leu Glu  Thr Ala Ala Pro Gly  Val Glu Asp 

    1130                 1135                 1140             





Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu Glu Thr  Ala Ala Pro 

    1145                 1150                 1155             





Gly Val  Glu Asp Ile Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu 

    1160                 1165                 1170             





Thr Ala  Ala Pro Gly Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly 

    1175                 1180                 1185             





Glu Val  Leu Glu Thr Ala Ala  Pro Gly Val Glu Asp  Ile Ser Gly 

    1190                 1195                 1200             





Leu Pro  Ser Gly Glu Val Leu  Glu Thr Ala Ala Pro  Gly Val Glu 

    1205                 1210                 1215             





Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val Leu Glu  Thr Ala Ala 

    1220                 1225                 1230             





Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu 

    1235                 1240                 1245             





Glu Thr  Ala Ala Pro Gly Val  Glu Asp Ile Ser Gly  Leu Pro Ser 

    1250                 1255                 1260             





Gly Glu  Val Leu Glu Thr Ala  Ala Pro Gly Val Glu  Asp Ile Ser 

    1265                 1270                 1275             





Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr Ala Ala  Pro Gly Val 

    1280                 1285                 1290             





Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu Val Leu  Glu Thr Ala 

    1295                 1300                 1305             





Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val 

    1310                 1315                 1320             





Leu Glu  Thr Ala Ala Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro 

    1325                 1330                 1335             





Ser Gly  Glu Val Leu Glu Thr  Ala Ala Pro Gly Val  Glu Asp Ile 

    1340                 1345                 1350             





Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu Thr Ala  Ala Pro Gly 

    1355                 1360                 1365             





Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr 

    1370                 1375                 1380             





Ala Ala  Pro Gly Val Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu 

    1385                 1390                 1395             





Val Leu  Glu Thr Thr Ala Pro  Gly Val Glu Glu Ile  Ser Gly Leu 

    1400                 1405                 1410             





Pro Ser  Gly Glu Val Leu Glu  Thr Thr Ala Pro Gly  Val Asp Glu 

    1415                 1420                 1425             





Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu Glu Thr  Thr Ala Pro 

    1430                 1435                 1440             





Gly Val  Glu Glu Ile Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu 

    1445                 1450                 1455             





Thr Ser  Thr Ser Ala Val Gly  Asp Leu Ser Gly Leu  Pro Ser Gly 

    1460                 1465                 1470             





Gly Glu  Val Leu Glu Ile Ser  Val Ser Gly Val Glu  Asp Ile Ser 

    1475                 1480                 1485             





Gly Leu  Pro Ser Gly Glu Val  Val Glu Thr Ser Ala  Ser Gly Ile 

    1490                 1495                 1500             





Glu Asp  Val Ser Glu Leu Pro  Ser Gly Glu Gly Leu  Glu Thr Ser 

    1505                 1510                 1515             





Ala Ser  Gly Val Glu Asp Leu  Ser Arg Leu Pro Ser  Gly Glu Glu 

    1520                 1525                 1530             





Val Leu  Glu Ile Ser Ala Ser  Gly Phe Gly Asp Leu  Ser Gly Leu 

    1535                 1540                 1545             





Pro Ser  Gly Gly Glu Gly Leu  Glu Thr Ser Ala Ser  Glu Val Gly 

    1550                 1555                 1560             





Thr Asp  Leu Ser Gly Leu Pro  Ser Gly Arg Glu Gly  Leu Glu Thr 

    1565                 1570                 1575             





Ser Ala  Ser Gly Ala Glu Asp  Leu Ser Gly Leu Pro  Ser Gly Lys 

    1580                 1585                 1590             





Glu Asp  Leu Val Gly Ser Ala  Ser Gly Asp Leu Asp  Leu Gly Lys 

    1595                 1600                 1605             





Leu Pro  Ser Gly Thr Leu Gly  Ser Gly Gln Ala Pro  Glu Thr Ser 

    1610                 1615                 1620             





Gly Leu  Pro Ser Gly Phe Ser  Gly Glu Tyr Ser Gly  Val Asp Leu 

    1625                 1630                 1635             





Gly Ser  Gly Pro Pro Ser Gly  Leu Pro Asp Phe Ser  Gly Leu Pro 

    1640                 1645                 1650             





Ser Gly  Phe Pro Thr Val Ser  Leu Val Asp Ser Thr  Leu Val Glu 

    1655                 1660                 1665             





Val Val  Thr Ala Ser Thr Ala  Ser Glu Leu Glu Gly  Arg Gly Thr 

    1670                 1675                 1680             





Ile Gly  Ile Ser Gly Ala Gly  Glu Ile Ser Gly Leu  Pro Ser Ser 

    1685                 1690                 1695             





Glu Leu  Asp Ile Ser Gly Arg  Ala Ser Gly Leu Pro  Ser Gly Thr 

    1700                 1705                 1710             





Glu Leu  Ser Gly Gln Ala Ser  Gly Ser Pro Asp Val  Ser Gly Glu 

    1715                 1720                 1725             





Ile Pro  Gly Leu Phe Gly Val  Ser Gly Gln Pro Ser  Gly Phe Pro 

    1730                 1735                 1740             





Asp Thr  Ser Gly Glu Thr Ser  Gly Val Thr Glu Leu  Ser Gly Leu 

    1745                 1750                 1755             





Ser Ser  Gly Gln Pro Gly Ile  Ser Gly Glu Ala Ser  Gly Val Leu 

    1760                 1765                 1770             





Tyr Gly  Thr Ser Gln Pro Phe  Gly Ile Thr Asp Leu  Ser Gly Glu 

    1775                 1780                 1785             





Thr Ser  Gly Val Pro Asp Leu  Ser Gly Gln Pro Ser  Gly Leu Pro 

    1790                 1795                 1800             





Gly Phe  Ser Gly Ala Thr Ser  Gly Val Pro Asp Leu  Val Ser Gly 

    1805                 1810                 1815             





Thr Thr  Ser Gly Ser Gly Glu  Ser Ser Gly Ile Thr  Phe Val Asp 

    1820                 1825                 1830             





Thr Ser  Leu Val Glu Val Ala  Pro Thr Thr Phe Lys  Glu Glu Glu 

    1835                 1840                 1845             





Gly Leu  Gly Ser Val Glu Leu  Ser Gly Leu Pro Ser  Gly Glu Ala 

    1850                 1855                 1860             





Asp Leu  Ser Gly Lys Ser Gly  Met Val Asp Val Ser  Gly Gln Phe 

    1865                 1870                 1875             





Ser Gly  Thr Val Asp Ser Ser  Gly Phe Thr Ser Gln  Thr Pro Glu 

    1880                 1885                 1890             





Phe Ser  Gly Leu Pro Ser Gly  Ile Ala Glu Val Ser  Gly Glu Ser 

    1895                 1900                 1905             





Ser Arg  Ala Glu Ile Gly Ser  Ser Leu Pro Ser Gly  Ala Tyr Tyr 

    1910                 1915                 1920             





Gly Ser  Gly Thr Pro Ser Ser  Phe Pro Thr Val Ser  Leu Val Asp 

    1925                 1930                 1935             





Arg Thr  Leu Val Glu Ser Val  Thr Gln Ala Pro Thr  Ala Gln Glu 

    1940                 1945                 1950             





Ala Gly  Glu Gly Pro Ser Gly  Ile Leu Glu Leu Ser  Gly Ala His 

    1955                 1960                 1965             





Ser Gly  Ala Pro Asp Met Ser  Gly Glu His Ser Gly  Phe Leu Asp 

    1970                 1975                 1980             





Leu Ser  Gly Leu Gln Ser Gly  Leu Ile Glu Pro Ser  Gly Glu Pro 

    1985                 1990                 1995             





Pro Gly  Thr Pro Tyr Phe Ser  Gly Asp Phe Ala Ser  Thr Thr Asn 

    2000                 2005                 2010             





Val Ser  Gly Glu Ser Ser Val  Ala Met Gly Thr Ser  Gly Glu Ala 

    2015                 2020                 2025             





Ser Gly  Leu Pro Glu Val Thr  Leu Ile Thr Ser Glu  Phe Val Glu 

    2030                 2035                 2040             





Gly Val  Thr Glu Pro Thr Ile  Ser Gln Glu Leu Gly  Gln Arg Pro 

    2045                 2050                 2055             





Pro Val  Thr His Thr Pro Gln  Leu Phe Glu Ser Ser  Gly Lys Val 

    2060                 2065                 2070             





Ser Thr  Ala Gly Asp Ile Ser  Gly Ala Thr Pro Val  Leu Pro Gly 

    2075                 2080                 2085             





Ser Gly  Val Glu Val Ser Ser  Val Pro Glu Ser Ser  Ser Glu Thr 

    2090                 2095                 2100             





Ser Ala  Tyr Pro Glu Ala Gly  Phe Gly Ala Ser Ala  Ala Pro Glu 

    2105                 2110                 2115             





Ala Ser  Arg Glu Asp Ser Gly  Ser Pro Asp Leu Ser  Glu Thr Thr 

    2120                 2125                 2130             





Ser Ala  Phe His Glu Ala Asn  Leu Glu Arg Ser Ser  Gly Leu Gly 

    2135                 2140                 2145             





Val Ser  Gly Ser Thr Leu Thr  Phe Gln Glu Gly Glu  Ala Ser Ala 

    2150                 2155                 2160             





Ala Pro  Glu Val Ser Gly Glu  Ser Thr Thr Thr Ser  Asp Val Gly 

    2165                 2170                 2175             





Thr Glu  Ala Pro Gly Leu Pro  Ser Ala Thr Pro Thr  Ala Ser Gly 

    2180                 2185                 2190             





Asp Arg  Thr Glu Ile Ser Gly  Asp Leu Ser Gly His  Thr Ser Gln 

    2195                 2200                 2205             





Leu Gly  Val Val Ile Ser Thr  Ser Ile Pro Glu Ser  Glu Trp Thr 

    2210                 2215                 2220             





Gln Gln  Thr Gln Arg Pro Ala  Glu Thr His Leu Glu  Ile Glu Ser 

    2225                 2230                 2235             





Ser Ser  Leu Leu Tyr Ser Gly  Glu Glu Thr His Thr  Val Glu Thr 

    2240                 2245                 2250             





Ala Thr  Ser Pro Thr Asp Ala  Ser Ile Pro Ala Ser  Pro Glu Trp 

    2255                 2260                 2265             





Lys Arg  Glu Ser Glu Ser Thr  Ala Ala Asp Gln Glu  Val Cys Glu 

    2270                 2275                 2280             





Glu Gly  Trp Asn Lys Tyr Gln  Gly His Cys Tyr Arg  His Phe Pro 

    2285                 2290                 2295             





Asp Arg  Glu Thr Trp Val Asp  Ala Glu Arg Arg Cys  Arg Glu Gln 

    2300                 2305                 2310             





Gln Ser  His Leu Ser Ser Ile  Val Thr Pro Glu Glu  Gln Glu Phe 

    2315                 2320                 2325             





Val Asn  Asn Asn Ala Gln Asp  Tyr Gln Trp Ile Gly  Leu Asn Asp 

    2330                 2335                 2340             





Arg Thr  Ile Glu Gly Asp Phe  Arg Trp Ser Asp Gly  His Pro Met 

    2345                 2350                 2355             





Gln Phe  Glu Asn Trp Arg Pro  Asn Gln Pro Asp Asn  Phe Phe Ala 

    2360                 2365                 2370             





Ala Gly  Glu Asp Cys Val Val  Met Ile Trp His Glu  Lys Gly Glu 

    2375                 2380                 2385             





Trp Asn  Asp Val Pro Cys Asn  Tyr His Leu Pro Phe  Thr Cys Lys 

    2390                 2395                 2400             





Lys Gly  Thr Ala Thr Thr Tyr  Lys Arg Arg Leu Gln  Lys Arg Ser 

    2405                 2410                 2415             





Ser Arg  His Pro Arg Arg Ser  Arg Pro Ser Thr Ala  His 

    2420                 2425                 2430     





<210>  75

<211>  2530

<212>  PRT

<213>  Homo sapiens



<400>  75



Met Thr Thr Leu Leu Trp Val Phe Val Thr Leu Arg Val Ile Thr Ala 

1               5                   10                  15      





Ala Val Thr Val Glu Thr Ser Asp His Asp Asn Ser Leu Ser Val Ser 

            20                  25                  30          





Ile Pro Gln Pro Ser Pro Leu Arg Val Leu Leu Gly Thr Ser Leu Thr 

        35                  40                  45              





Ile Pro Cys Tyr Phe Ile Asp Pro Met His Pro Val Thr Thr Ala Pro 

    50                  55                  60                  





Ser Thr Ala Pro Leu Ala Pro Arg Ile Lys Trp Ser Arg Val Ser Lys 

65                  70                  75                  80  





Glu Lys Glu Val Val Leu Leu Val Ala Thr Glu Gly Arg Val Arg Val 

                85                  90                  95      





Asn Ser Ala Tyr Gln Asp Lys Val Ser Leu Pro Asn Tyr Pro Ala Ile 

            100                 105                 110         





Pro Ser Asp Ala Thr Leu Glu Val Gln Ser Leu Arg Ser Asn Asp Ser 

        115                 120                 125             





Gly Val Tyr Arg Cys Glu Val Met His Gly Ile Glu Asp Ser Glu Ala 

    130                 135                 140                 





Thr Leu Glu Val Val Val Lys Gly Ile Val Phe His Tyr Arg Ala Ile 

145                 150                 155                 160 





Ser Thr Arg Tyr Thr Leu Asp Phe Asp Arg Ala Gln Arg Ala Cys Leu 

                165                 170                 175     





Gln Asn Ser Ala Ile Ile Ala Thr Pro Glu Gln Leu Gln Ala Ala Tyr 

            180                 185                 190         





Glu Asp Gly Phe His Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr 

        195                 200                 205             





Val Arg Tyr Pro Ile His Thr Pro Arg Glu Gly Cys Tyr Gly Asp Lys 

    210                 215                 220                 





Asp Glu Phe Pro Gly Val Arg Thr Tyr Gly Ile Arg Asp Thr Asn Glu 

225                 230                 235                 240 





Thr Tyr Asp Val Tyr Cys Phe Ala Glu Glu Met Glu Gly Glu Val Phe 

                245                 250                 255     





Tyr Ala Thr Ser Pro Glu Lys Phe Thr Phe Gln Glu Ala Ala Asn Glu 

            260                 265                 270         





Cys Arg Arg Leu Gly Ala Arg Leu Ala Thr Thr Gly Gln Leu Tyr Leu 

        275                 280                 285             





Ala Trp Gln Ala Gly Met Asp Met Cys Ser Ala Gly Trp Leu Ala Asp 

    290                 295                 300                 





Arg Ser Val Arg Tyr Pro Ile Ser Lys Ala Arg Pro Asn Cys Gly Gly 

305                 310                 315                 320 





Asn Leu Leu Gly Val Arg Thr Val Tyr Val His Ala Asn Gln Thr Gly 

                325                 330                 335     





Tyr Pro Asp Pro Ser Ser Arg Tyr Asp Ala Ile Cys Tyr Thr Gly Glu 

            340                 345                 350         





Asp Phe Val Asp Ile Pro Glu Asn Phe Phe Gly Val Gly Gly Glu Glu 

        355                 360                 365             





Asp Ile Thr Val Gln Thr Val Thr Trp Pro Asp Met Glu Leu Pro Leu 

    370                 375                 380                 





Pro Arg Asn Ile Thr Glu Gly Glu Ala Arg Gly Ser Val Ile Leu Thr 

385                 390                 395                 400 





Val Lys Pro Ile Phe Glu Val Ser Pro Ser Pro Leu Glu Pro Glu Glu 

                405                 410                 415     





Pro Phe Thr Phe Ala Pro Glu Ile Gly Ala Thr Ala Phe Ala Glu Val 

            420                 425                 430         





Glu Asn Glu Thr Gly Glu Ala Thr Arg Pro Trp Gly Phe Pro Thr Pro 

        435                 440                 445             





Gly Leu Gly Pro Ala Thr Ala Phe Thr Ser Glu Asp Leu Val Val Gln 

    450                 455                 460                 





Val Thr Ala Val Pro Gly Gln Pro His Leu Pro Gly Gly Val Val Phe 

465                 470                 475                 480 





His Tyr Arg Pro Gly Pro Thr Arg Tyr Ser Leu Thr Phe Glu Glu Ala 

                485                 490                 495     





Gln Gln Ala Cys Leu Arg Thr Gly Ala Val Ile Ala Ser Pro Glu Gln 

            500                 505                 510         





Leu Gln Ala Ala Tyr Glu Ala Gly Tyr Glu Gln Cys Asp Ala Gly Trp 

        515                 520                 525             





Leu Arg Asp Gln Thr Val Arg Tyr Pro Ile Val Ser Pro Arg Thr Pro 

    530                 535                 540                 





Cys Val Gly Asp Lys Asp Ser Ser Pro Gly Val Arg Thr Tyr Gly Val 

545                 550                 555                 560 





Arg Pro Ser Thr Glu Thr Tyr Asp Val Tyr Cys Phe Val Asp Arg Leu 

                565                 570                 575     





Glu Gly Glu Val Phe Phe Ala Thr Arg Leu Glu Gln Phe Thr Phe Gln 

            580                 585                 590         





Glu Ala Leu Glu Phe Cys Glu Ser His Asn Ala Thr Leu Ala Thr Thr 

        595                 600                 605             





Gly Gln Leu Tyr Ala Ala Trp Ser Arg Gly Leu Asp Lys Cys Tyr Ala 

    610                 615                 620                 





Gly Trp Leu Ala Asp Gly Ser Leu Arg Tyr Pro Ile Val Thr Pro Arg 

625                 630                 635                 640 





Pro Ala Cys Gly Gly Asp Lys Pro Gly Val Arg Thr Val Tyr Leu Tyr 

                645                 650                 655     





Pro Asn Gln Thr Gly Leu Pro Asp Pro Leu Ser Arg His His Ala Phe 

            660                 665                 670         





Cys Phe Arg Gly Ile Ser Ala Val Pro Ser Pro Gly Glu Glu Glu Gly 

        675                 680                 685             





Gly Thr Pro Thr Ser Pro Ser Gly Val Glu Glu Trp Ile Val Thr Gln 

    690                 695                 700                 





Val Val Pro Gly Val Ala Ala Val Pro Val Glu Glu Glu Thr Thr Ala 

705                 710                 715                 720 





Val Pro Ser Gly Glu Thr Thr Ala Ile Leu Glu Phe Thr Thr Glu Pro 

                725                 730                 735     





Glu Asn Gln Thr Glu Trp Glu Pro Ala Tyr Thr Pro Val Gly Thr Ser 

            740                 745                 750         





Pro Leu Pro Gly Ile Leu Pro Thr Trp Pro Pro Thr Gly Ala Ala Thr 

        755                 760                 765             





Glu Glu Ser Thr Glu Gly Pro Ser Ala Thr Glu Val Pro Ser Ala Ser 

    770                 775                 780                 





Glu Glu Pro Ser Pro Ser Glu Val Pro Phe Pro Ser Glu Glu Pro Ser 

785                 790                 795                 800 





Pro Ser Glu Glu Pro Phe Pro Ser Val Arg Pro Phe Pro Ser Val Glu 

                805                 810                 815     





Leu Phe Pro Ser Glu Glu Pro Phe Pro Ser Lys Glu Pro Ser Pro Ser 

            820                 825                 830         





Glu Glu Pro Ser Ala Ser Glu Glu Pro Tyr Thr Pro Ser Pro Pro Val 

        835                 840                 845             





Pro Ser Trp Thr Glu Leu Pro Ser Ser Gly Glu Glu Ser Gly Ala Pro 

    850                 855                 860                 





Asp Val Ser Gly Asp Phe Thr Gly Ser Gly Asp Val Ser Gly His Leu 

865                 870                 875                 880 





Asp Phe Ser Gly Gln Leu Ser Gly Asp Arg Ala Ser Gly Leu Pro Ser 

                885                 890                 895     





Gly Asp Leu Asp Ser Ser Gly Leu Thr Ser Thr Val Gly Ser Gly Leu 

            900                 905                 910         





Pro Val Glu Ser Gly Leu Pro Ser Gly Asp Glu Glu Arg Ile Glu Trp 

        915                 920                 925             





Pro Ser Thr Pro Thr Val Gly Glu Leu Pro Ser Gly Ala Glu Ile Leu 

    930                 935                 940                 





Glu Gly Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu Pro Ser Gly 

945                 950                 955                 960 





Glu Val Leu Glu Thr Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu 

                965                 970                 975     





Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val Glu Asp Ile 

            980                 985                 990         





Ser Gly Leu Pro Ser Gly Glu Val  Leu Glu Thr Thr Ala  Pro Gly Val 

        995                 1000                 1005             





Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu Val Leu  Glu Thr Thr 

    1010                 1015                 1020             





Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val 

    1025                 1030                 1035             





Leu Glu  Thr Thr Ala Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro 

    1040                 1045                 1050             





Ser Gly  Glu Val Leu Glu Thr  Thr Ala Pro Gly Val  Glu Asp Ile 

    1055                 1060                 1065             





Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu Thr Thr  Ala Pro Gly 

    1070                 1075                 1080             





Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr 

    1085                 1090                 1095             





Ala Ala  Pro Gly Val Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu 

    1100                 1105                 1110             





Val Leu  Glu Thr Ala Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu 

    1115                 1120                 1125             





Pro Ser  Gly Glu Val Leu Glu  Thr Ala Ala Pro Gly  Val Glu Asp 

    1130                 1135                 1140             





Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu Glu Thr  Ala Ala Pro 

    1145                 1150                 1155             





Gly Val  Glu Asp Ile Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu 

    1160                 1165                 1170             





Thr Ala  Ala Pro Gly Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly 

    1175                 1180                 1185             





Glu Val  Leu Glu Thr Ala Ala  Pro Gly Val Glu Asp  Ile Ser Gly 

    1190                 1195                 1200             





Leu Pro  Ser Gly Glu Val Leu  Glu Thr Ala Ala Pro  Gly Val Glu 

    1205                 1210                 1215             





Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val Leu Glu  Thr Ala Ala 

    1220                 1225                 1230             





Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu 

    1235                 1240                 1245             





Glu Thr  Ala Ala Pro Gly Val  Glu Asp Ile Ser Gly  Leu Pro Ser 

    1250                 1255                 1260             





Gly Glu  Val Leu Glu Thr Ala  Ala Pro Gly Val Glu  Asp Ile Ser 

    1265                 1270                 1275             





Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr Ala Ala  Pro Gly Val 

    1280                 1285                 1290             





Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu Val Leu  Glu Thr Ala 

    1295                 1300                 1305             





Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val 

    1310                 1315                 1320             





Leu Glu  Thr Ala Ala Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro 

    1325                 1330                 1335             





Ser Gly  Glu Val Leu Glu Thr  Ala Ala Pro Gly Val  Glu Asp Ile 

    1340                 1345                 1350             





Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu Thr Ala  Ala Pro Gly 

    1355                 1360                 1365             





Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr 

    1370                 1375                 1380             





Ala Ala  Pro Gly Val Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu 

    1385                 1390                 1395             





Val Leu  Glu Thr Thr Ala Pro  Gly Val Glu Glu Ile  Ser Gly Leu 

    1400                 1405                 1410             





Pro Ser  Gly Glu Val Leu Glu  Thr Thr Ala Pro Gly  Val Asp Glu 

    1415                 1420                 1425             





Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu Glu Thr  Thr Ala Pro 

    1430                 1435                 1440             





Gly Val  Glu Glu Ile Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu 

    1445                 1450                 1455             





Thr Ser  Thr Ser Ala Val Gly  Asp Leu Ser Gly Leu  Pro Ser Gly 

    1460                 1465                 1470             





Gly Glu  Val Leu Glu Ile Ser  Val Ser Gly Val Glu  Asp Ile Ser 

    1475                 1480                 1485             





Gly Leu  Pro Ser Gly Glu Val  Val Glu Thr Ser Ala  Ser Gly Ile 

    1490                 1495                 1500             





Glu Asp  Val Ser Glu Leu Pro  Ser Gly Glu Gly Leu  Glu Thr Ser 

    1505                 1510                 1515             





Ala Ser  Gly Val Glu Asp Leu  Ser Arg Leu Pro Ser  Gly Glu Glu 

    1520                 1525                 1530             





Val Leu  Glu Ile Ser Ala Ser  Gly Phe Gly Asp Leu  Ser Gly Leu 

    1535                 1540                 1545             





Pro Ser  Gly Gly Glu Gly Leu  Glu Thr Ser Ala Ser  Glu Val Gly 

    1550                 1555                 1560             





Thr Asp  Leu Ser Gly Leu Pro  Ser Gly Arg Glu Gly  Leu Glu Thr 

    1565                 1570                 1575             





Ser Ala  Ser Gly Ala Glu Asp  Leu Ser Gly Leu Pro  Ser Gly Lys 

    1580                 1585                 1590             





Glu Asp  Leu Val Gly Ser Ala  Ser Gly Asp Leu Asp  Leu Gly Lys 

    1595                 1600                 1605             





Leu Pro  Ser Gly Thr Leu Gly  Ser Gly Gln Ala Pro  Glu Thr Ser 

    1610                 1615                 1620             





Gly Leu  Pro Ser Gly Phe Ser  Gly Glu Tyr Ser Gly  Val Asp Leu 

    1625                 1630                 1635             





Gly Ser  Gly Pro Pro Ser Gly  Leu Pro Asp Phe Ser  Gly Leu Pro 

    1640                 1645                 1650             





Ser Gly  Phe Pro Thr Val Ser  Leu Val Asp Ser Thr  Leu Val Glu 

    1655                 1660                 1665             





Val Val  Thr Ala Ser Thr Ala  Ser Glu Leu Glu Gly  Arg Gly Thr 

    1670                 1675                 1680             





Ile Gly  Ile Ser Gly Ala Gly  Glu Ile Ser Gly Leu  Pro Ser Ser 

    1685                 1690                 1695             





Glu Leu  Asp Ile Ser Gly Arg  Ala Ser Gly Leu Pro  Ser Gly Thr 

    1700                 1705                 1710             





Glu Leu  Ser Gly Gln Ala Ser  Gly Ser Pro Asp Val  Ser Gly Glu 

    1715                 1720                 1725             





Ile Pro  Gly Leu Phe Gly Val  Ser Gly Gln Pro Ser  Gly Phe Pro 

    1730                 1735                 1740             





Asp Thr  Ser Gly Glu Thr Ser  Gly Val Thr Glu Leu  Ser Gly Leu 

    1745                 1750                 1755             





Ser Ser  Gly Gln Pro Gly Ile  Ser Gly Glu Ala Ser  Gly Val Leu 

    1760                 1765                 1770             





Tyr Gly  Thr Ser Gln Pro Phe  Gly Ile Thr Asp Leu  Ser Gly Glu 

    1775                 1780                 1785             





Thr Ser  Gly Val Pro Asp Leu  Ser Gly Gln Pro Ser  Gly Leu Pro 

    1790                 1795                 1800             





Gly Phe  Ser Gly Ala Thr Ser  Gly Val Pro Asp Leu  Val Ser Gly 

    1805                 1810                 1815             





Thr Thr  Ser Gly Ser Gly Glu  Ser Ser Gly Ile Thr  Phe Val Asp 

    1820                 1825                 1830             





Thr Ser  Leu Val Glu Val Ala  Pro Thr Thr Phe Lys  Glu Glu Glu 

    1835                 1840                 1845             





Gly Leu  Gly Ser Val Glu Leu  Ser Gly Leu Pro Ser  Gly Glu Ala 

    1850                 1855                 1860             





Asp Leu  Ser Gly Lys Ser Gly  Met Val Asp Val Ser  Gly Gln Phe 

    1865                 1870                 1875             





Ser Gly  Thr Val Asp Ser Ser  Gly Phe Thr Ser Gln  Thr Pro Glu 

    1880                 1885                 1890             





Phe Ser  Gly Leu Pro Ser Gly  Ile Ala Glu Val Ser  Gly Glu Ser 

    1895                 1900                 1905             





Ser Arg  Ala Glu Ile Gly Ser  Ser Leu Pro Ser Gly  Ala Tyr Tyr 

    1910                 1915                 1920             





Gly Ser  Gly Thr Pro Ser Ser  Phe Pro Thr Val Ser  Leu Val Asp 

    1925                 1930                 1935             





Arg Thr  Leu Val Glu Ser Val  Thr Gln Ala Pro Thr  Ala Gln Glu 

    1940                 1945                 1950             





Ala Gly  Glu Gly Pro Ser Gly  Ile Leu Glu Leu Ser  Gly Ala His 

    1955                 1960                 1965             





Ser Gly  Ala Pro Asp Met Ser  Gly Glu His Ser Gly  Phe Leu Asp 

    1970                 1975                 1980             





Leu Ser  Gly Leu Gln Ser Gly  Leu Ile Glu Pro Ser  Gly Glu Pro 

    1985                 1990                 1995             





Pro Gly  Thr Pro Tyr Phe Ser  Gly Asp Phe Ala Ser  Thr Thr Asn 

    2000                 2005                 2010             





Val Ser  Gly Glu Ser Ser Val  Ala Met Gly Thr Ser  Gly Glu Ala 

    2015                 2020                 2025             





Ser Gly  Leu Pro Glu Val Thr  Leu Ile Thr Ser Glu  Phe Val Glu 

    2030                 2035                 2040             





Gly Val  Thr Glu Pro Thr Ile  Ser Gln Glu Leu Gly  Gln Arg Pro 

    2045                 2050                 2055             





Pro Val  Thr His Thr Pro Gln  Leu Phe Glu Ser Ser  Gly Lys Val 

    2060                 2065                 2070             





Ser Thr  Ala Gly Asp Ile Ser  Gly Ala Thr Pro Val  Leu Pro Gly 

    2075                 2080                 2085             





Ser Gly  Val Glu Val Ser Ser  Val Pro Glu Ser Ser  Ser Glu Thr 

    2090                 2095                 2100             





Ser Ala  Tyr Pro Glu Ala Gly  Phe Gly Ala Ser Ala  Ala Pro Glu 

    2105                 2110                 2115             





Ala Ser  Arg Glu Asp Ser Gly  Ser Pro Asp Leu Ser  Glu Thr Thr 

    2120                 2125                 2130             





Ser Ala  Phe His Glu Ala Asn  Leu Glu Arg Ser Ser  Gly Leu Gly 

    2135                 2140                 2145             





Val Ser  Gly Ser Thr Leu Thr  Phe Gln Glu Gly Glu  Ala Ser Ala 

    2150                 2155                 2160             





Ala Pro  Glu Val Ser Gly Glu  Ser Thr Thr Thr Ser  Asp Val Gly 

    2165                 2170                 2175             





Thr Glu  Ala Pro Gly Leu Pro  Ser Ala Thr Pro Thr  Ala Ser Gly 

    2180                 2185                 2190             





Asp Arg  Thr Glu Ile Ser Gly  Asp Leu Ser Gly His  Thr Ser Gln 

    2195                 2200                 2205             





Leu Gly  Val Val Ile Ser Thr  Ser Ile Pro Glu Ser  Glu Trp Thr 

    2210                 2215                 2220             





Gln Gln  Thr Gln Arg Pro Ala  Glu Thr His Leu Glu  Ile Glu Ser 

    2225                 2230                 2235             





Ser Ser  Leu Leu Tyr Ser Gly  Glu Glu Thr His Thr  Val Glu Thr 

    2240                 2245                 2250             





Ala Thr  Ser Pro Thr Asp Ala  Ser Ile Pro Ala Ser  Pro Glu Trp 

    2255                 2260                 2265             





Lys Arg  Glu Ser Glu Ser Thr  Ala Ala Ala Pro Ala  Arg Ser Cys 

    2270                 2275                 2280             





Ala Glu  Glu Pro Cys Gly Ala  Gly Thr Cys Lys Glu  Thr Glu Gly 

    2285                 2290                 2295             





His Val  Ile Cys Leu Cys Pro  Pro Gly Tyr Thr Gly  Glu His Cys 

    2300                 2305                 2310             





Asn Ile  Asp Gln Glu Val Cys  Glu Glu Gly Trp Asn  Lys Tyr Gln 

    2315                 2320                 2325             





Gly His  Cys Tyr Arg His Phe  Pro Asp Arg Glu Thr  Trp Val Asp 

    2330                 2335                 2340             





Ala Glu  Arg Arg Cys Arg Glu  Gln Gln Ser His Leu  Ser Ser Ile 

    2345                 2350                 2355             





Val Thr  Pro Glu Glu Gln Glu  Phe Val Asn Asn Asn  Ala Gln Asp 

    2360                 2365                 2370             





Tyr Gln  Trp Ile Gly Leu Asn  Asp Arg Thr Ile Glu  Gly Asp Phe 

    2375                 2380                 2385             





Arg Trp  Ser Asp Gly His Pro  Met Gln Phe Glu Asn  Trp Arg Pro 

    2390                 2395                 2400             





Asn Gln  Pro Asp Asn Phe Phe  Ala Ala Gly Glu Asp  Cys Val Val 

    2405                 2410                 2415             





Met Ile  Trp His Glu Lys Gly  Glu Trp Asn Asp Val  Pro Cys Asn 

    2420                 2425                 2430             





Tyr His  Leu Pro Phe Thr Cys  Lys Lys Gly Thr Val  Ala Cys Gly 

    2435                 2440                 2445             





Glu Pro  Pro Val Val Glu His  Ala Arg Thr Phe Gly  Gln Lys Lys 

    2450                 2455                 2460             





Asp Arg  Tyr Glu Ile Asn Ser  Leu Val Arg Tyr Gln  Cys Thr Glu 

    2465                 2470                 2475             





Gly Phe  Val Gln Arg His Met  Pro Thr Ile Arg Cys  Gln Pro Ser 

    2480                 2485                 2490             





Gly His  Trp Glu Glu Pro Gln  Ile Thr Cys Thr Asp  Pro Thr Thr 

    2495                 2500                 2505             





Tyr Lys  Arg Arg Leu Gln Lys  Arg Ser Ser Arg His  Pro Arg Arg 

    2510                 2515                 2520             





Ser Arg  Pro Ser Thr Ala His  

    2525                 2530 





<210>  76

<211>  607

<212>  PRT

<213>  Homo sapiens



<400>  76



Met Ile Leu Leu Thr Phe Ser Thr Gly Arg Arg Leu Asp Phe Val His 

1               5                   10                  15      





His Ser Gly Val Phe Phe Leu Gln Thr Leu Leu Trp Ile Leu Cys Ala 

            20                  25                  30          





Thr Val Cys Gly Thr Glu Gln Tyr Phe Asn Val Glu Val Trp Leu Gln 

        35                  40                  45              





Lys Tyr Gly Tyr Leu Pro Pro Thr Asp Pro Arg Met Ser Val Leu Arg 

    50                  55                  60                  





Ser Ala Glu Thr Met Gln Ser Ala Leu Ala Ala Met Gln Gln Phe Tyr 

65                  70                  75                  80  





Gly Ile Asn Met Thr Gly Lys Val Asp Arg Asn Thr Ile Asp Trp Met 

                85                  90                  95      





Lys Lys Pro Arg Cys Gly Val Pro Asp Gln Thr Arg Gly Ser Ser Lys 

            100                 105                 110         





Phe His Ile Arg Arg Lys Arg Tyr Ala Leu Thr Gly Gln Lys Trp Gln 

        115                 120                 125             





His Lys His Ile Thr Tyr Ser Ile Lys Asn Val Thr Pro Lys Val Gly 

    130                 135                 140                 





Asp Pro Glu Thr Arg Lys Ala Ile Arg Arg Ala Phe Asp Val Trp Gln 

145                 150                 155                 160 





Asn Val Thr Pro Leu Thr Phe Glu Glu Val Pro Tyr Ser Glu Leu Glu 

                165                 170                 175     





Asn Gly Lys Arg Asp Val Asp Ile Thr Ile Ile Phe Ala Ser Gly Phe 

            180                 185                 190         





His Gly Asp Ser Ser Pro Phe Asp Gly Glu Gly Gly Phe Leu Ala His 

        195                 200                 205             





Ala Tyr Phe Pro Gly Pro Gly Ile Gly Gly Asp Thr His Phe Asp Ser 

    210                 215                 220                 





Asp Glu Pro Trp Thr Leu Gly Asn Pro Asn His Asp Gly Asn Asp Leu 

225                 230                 235                 240 





Phe Leu Val Ala Val His Glu Leu Gly His Ala Leu Gly Leu Glu His 

                245                 250                 255     





Ser Asn Asp Pro Thr Ala Ile Met Ala Pro Phe Tyr Gln Tyr Met Glu 

            260                 265                 270         





Thr Asp Asn Phe Lys Leu Pro Asn Asp Asp Leu Gln Gly Ile Gln Lys 

        275                 280                 285             





Ile Tyr Gly Pro Pro Asp Lys Ile Pro Pro Pro Thr Arg Pro Leu Pro 

    290                 295                 300                 





Thr Val Pro Pro His Arg Ser Ile Pro Pro Ala Asp Pro Arg Lys Asn 

305                 310                 315                 320 





Asp Arg Pro Lys Pro Pro Arg Pro Pro Thr Gly Arg Pro Ser Tyr Pro 

                325                 330                 335     





Gly Ala Lys Pro Asn Ile Cys Asp Gly Asn Phe Asn Thr Leu Ala Ile 

            340                 345                 350         





Leu Arg Arg Glu Met Phe Val Phe Lys Asp Gln Trp Phe Trp Arg Val 

        355                 360                 365             





Arg Asn Asn Arg Val Met Asp Gly Tyr Pro Met Gln Ile Thr Tyr Phe 

    370                 375                 380                 





Trp Arg Gly Leu Pro Pro Ser Ile Asp Ala Val Tyr Glu Asn Ser Asp 

385                 390                 395                 400 





Gly Asn Phe Val Phe Phe Lys Gly Asn Lys Tyr Trp Val Phe Lys Asp 

                405                 410                 415     





Thr Thr Leu Gln Pro Gly Tyr Pro His Asp Leu Ile Thr Leu Gly Ser 

            420                 425                 430         





Gly Ile Pro Pro His Gly Ile Asp Ser Ala Ile Trp Trp Glu Asp Val 

        435                 440                 445             





Gly Lys Thr Tyr Phe Phe Lys Gly Asp Arg Tyr Trp Arg Tyr Ser Glu 

    450                 455                 460                 





Glu Met Lys Thr Met Asp Pro Gly Tyr Pro Lys Pro Ile Thr Val Trp 

465                 470                 475                 480 





Lys Gly Ile Pro Glu Ser Pro Gln Gly Ala Phe Val His Lys Glu Asn 

                485                 490                 495     





Gly Phe Thr Tyr Phe Tyr Lys Gly Lys Glu Tyr Trp Lys Phe Asn Asn 

            500                 505                 510         





Gln Ile Leu Lys Val Glu Pro Gly Tyr Pro Arg Ser Ile Leu Lys Asp 

        515                 520                 525             





Phe Met Gly Cys Asp Gly Pro Thr Asp Arg Val Lys Glu Gly His Ser 

    530                 535                 540                 





Pro Pro Asp Asp Val Asp Ile Val Ile Lys Leu Asp Asn Thr Ala Ser 

545                 550                 555                 560 





Thr Val Lys Ala Ile Ala Ile Val Ile Pro Cys Ile Leu Ala Leu Cys 

                565                 570                 575     





Leu Leu Val Leu Val Tyr Thr Val Phe Gln Phe Lys Arg Lys Gly Thr 

            580                 585                 590         





Pro Arg His Ile Leu Tyr Cys Lys Arg Ser Met Gln Glu Trp Val 

        595                 600                 605         





<210>  77

<211>  4242

<212>  PRT

<213>  Homo sapiens



<400>  77



Met Met Pro Ala Gln Tyr Ala Leu Thr Ser Ser Leu Val Leu Leu Val 

1               5                   10                  15      





Leu Leu Ser Thr Ala Arg Ala Gly Pro Phe Ser Ser Arg Ser Asn Val 

            20                  25                  30          





Thr Leu Pro Ala Pro Arg Pro Pro Pro Gln Pro Gly Gly His Thr Val 

        35                  40                  45              





Gly Ala Gly Val Gly Ser Pro Ser Ser Gln Leu Tyr Glu His Thr Val 

    50                  55                  60                  





Glu Gly Gly Glu Lys Gln Val Val Phe Thr His Arg Ile Asn Leu Pro 

65                  70                  75                  80  





Pro Ser Thr Gly Cys Gly Cys Pro Pro Gly Thr Glu Pro Pro Val Leu 

                85                  90                  95      





Ala Ser Glu Val Gln Ala Leu Arg Val Arg Leu Glu Ile Leu Glu Glu 

            100                 105                 110         





Leu Val Lys Gly Leu Lys Glu Gln Cys Thr Gly Gly Cys Cys Pro Ala 

        115                 120                 125             





Ser Ala Gln Ala Gly Thr Gly Gln Thr Asp Val Arg Thr Leu Cys Ser 

    130                 135                 140                 





Leu His Gly Val Phe Asp Leu Ser Arg Cys Thr Cys Ser Cys Glu Pro 

145                 150                 155                 160 





Gly Trp Gly Gly Pro Thr Cys Ser Asp Pro Thr Asp Ala Glu Ile Pro 

                165                 170                 175     





Pro Ser Ser Pro Pro Ser Ala Ser Gly Ser Cys Pro Asp Asp Cys Asn 

            180                 185                 190         





Asp Gln Gly Arg Cys Val Arg Gly Arg Cys Val Cys Phe Pro Gly Tyr 

        195                 200                 205             





Thr Gly Pro Ser Cys Gly Trp Pro Ser Cys Pro Gly Asp Cys Gln Gly 

    210                 215                 220                 





Arg Gly Arg Cys Val Gln Gly Val Cys Val Cys Arg Ala Gly Phe Ser 

225                 230                 235                 240 





Gly Pro Asp Cys Ser Gln Arg Ser Cys Pro Arg Gly Cys Ser Gln Arg 

                245                 250                 255     





Gly Arg Cys Glu Gly Gly Arg Cys Val Cys Asp Pro Gly Tyr Thr Gly 

            260                 265                 270         





Asp Asp Cys Gly Met Arg Ser Cys Pro Arg Gly Cys Ser Gln Arg Gly 

        275                 280                 285             





Arg Cys Glu Asn Gly Arg Cys Val Cys Asn Pro Gly Tyr Thr Gly Glu 

    290                 295                 300                 





Asp Cys Gly Val Arg Ser Cys Pro Arg Gly Cys Ser Gln Arg Gly Arg 

305                 310                 315                 320 





Cys Lys Asp Gly Arg Cys Val Cys Asp Pro Gly Tyr Thr Gly Glu Asp 

                325                 330                 335     





Cys Gly Thr Arg Ser Cys Pro Trp Asp Cys Gly Glu Gly Gly Arg Cys 

            340                 345                 350         





Val Asp Gly Arg Cys Val Cys Trp Pro Gly Tyr Thr Gly Glu Asp Cys 

        355                 360                 365             





Ser Thr Arg Thr Cys Pro Arg Asp Cys Arg Gly Arg Gly Arg Cys Glu 

    370                 375                 380                 





Asp Gly Glu Cys Ile Cys Asp Thr Gly Tyr Ser Gly Asp Asp Cys Gly 

385                 390                 395                 400 





Val Arg Ser Cys Pro Gly Asp Cys Asn Gln Arg Gly Arg Cys Glu Asp 

                405                 410                 415     





Gly Arg Cys Val Cys Trp Pro Gly Tyr Thr Gly Thr Asp Cys Gly Ser 

            420                 425                 430         





Arg Ala Cys Pro Arg Asp Cys Arg Gly Arg Gly Arg Cys Glu Asn Gly 

        435                 440                 445             





Val Cys Val Cys Asn Ala Gly Tyr Ser Gly Glu Asp Cys Gly Val Arg 

    450                 455                 460                 





Ser Cys Pro Gly Asp Cys Arg Gly Arg Gly Arg Cys Glu Ser Gly Arg 

465                 470                 475                 480 





Cys Met Cys Trp Pro Gly Tyr Thr Gly Arg Asp Cys Gly Thr Arg Ala 

                485                 490                 495     





Cys Pro Gly Asp Cys Arg Gly Arg Gly Arg Cys Val Asp Gly Arg Cys 

            500                 505                 510         





Val Cys Asn Pro Gly Phe Thr Gly Glu Asp Cys Gly Ser Arg Arg Cys 

        515                 520                 525             





Pro Gly Asp Cys Arg Gly His Gly Leu Cys Glu Asp Gly Val Cys Val 

    530                 535                 540                 





Cys Asp Ala Gly Tyr Ser Gly Glu Asp Cys Ser Thr Arg Ser Cys Pro 

545                 550                 555                 560 





Gly Gly Cys Arg Gly Arg Gly Gln Cys Leu Asp Gly Arg Cys Val Cys 

                565                 570                 575     





Glu Asp Gly Tyr Ser Gly Glu Asp Cys Gly Val Arg Gln Cys Pro Asn 

            580                 585                 590         





Asp Cys Ser Gln His Gly Val Cys Gln Asp Gly Val Cys Ile Cys Trp 

        595                 600                 605             





Glu Gly Tyr Val Ser Glu Asp Cys Ser Ile Arg Thr Cys Pro Ser Asn 

    610                 615                 620                 





Cys His Gly Arg Gly Arg Cys Glu Glu Gly Arg Cys Leu Cys Asp Pro 

625                 630                 635                 640 





Gly Tyr Thr Gly Pro Thr Cys Ala Thr Arg Met Cys Pro Ala Asp Cys 

                645                 650                 655     





Arg Gly Arg Gly Arg Cys Val Gln Gly Val Cys Leu Cys His Val Gly 

            660                 665                 670         





Tyr Gly Gly Glu Asp Cys Gly Gln Glu Glu Pro Pro Ala Ser Ala Cys 

        675                 680                 685             





Pro Gly Gly Cys Gly Pro Arg Glu Leu Cys Arg Ala Gly Gln Cys Val 

    690                 695                 700                 





Cys Val Glu Gly Phe Arg Gly Pro Asp Cys Ala Ile Gln Thr Cys Pro 

705                 710                 715                 720 





Gly Asp Cys Arg Gly Arg Gly Glu Cys His Asp Gly Ser Cys Val Cys 

                725                 730                 735     





Lys Asp Gly Tyr Ala Gly Glu Asp Cys Gly Glu Glu Val Pro Thr Ile 

            740                 745                 750         





Glu Gly Met Arg Met His Leu Leu Glu Glu Thr Thr Val Arg Thr Glu 

        755                 760                 765             





Trp Thr Pro Ala Pro Gly Pro Val Asp Ala Tyr Glu Ile Gln Phe Ile 

    770                 775                 780                 





Pro Thr Thr Glu Gly Ala Ser Pro Pro Phe Thr Ala Arg Val Pro Ser 

785                 790                 795                 800 





Ser Ala Ser Ala Tyr Asp Gln Arg Gly Leu Ala Pro Gly Gln Glu Tyr 

                805                 810                 815     





Gln Val Thr Val Arg Ala Leu Arg Gly Thr Ser Trp Gly Leu Pro Ala 

            820                 825                 830         





Ser Lys Thr Ile Thr Thr Met Ile Asp Gly Pro Gln Asp Leu Arg Val 

        835                 840                 845             





Val Ala Val Thr Pro Thr Thr Leu Glu Leu Gly Trp Leu Arg Pro Gln 

    850                 855                 860                 





Ala Glu Val Asp Arg Phe Val Val Ser Tyr Val Ser Ala Gly Asn Gln 

865                 870                 875                 880 





Arg Val Arg Leu Glu Val Pro Pro Glu Ala Asp Gly Thr Leu Leu Thr 

                885                 890                 895     





Asp Leu Met Pro Gly Val Glu Tyr Val Val Thr Val Thr Ala Glu Arg 

            900                 905                 910         





Gly Arg Ala Val Ser Tyr Pro Ala Ser Val Arg Ala Asn Thr Gly Ser 

        915                 920                 925             





Ser Pro Leu Gly Leu Leu Gly Thr Thr Asp Glu Pro Pro Pro Ser Gly 

    930                 935                 940                 





Pro Ser Thr Thr Gln Gly Ala Gln Ala Pro Leu Leu Gln Gln Arg Pro 

945                 950                 955                 960 





Gln Glu Leu Gly Glu Leu Arg Val Leu Gly Arg Asp Glu Thr Gly Arg 

                965                 970                 975     





Leu Arg Val Val Trp Thr Ala Gln Pro Asp Thr Phe Ala Tyr Phe Gln 

            980                 985                 990         





Leu Arg Met Arg Val Pro Glu Gly  Pro Gly Ala His Glu  Glu Val Leu 

        995                 1000                 1005             





Pro Gly  Asp Val Arg Gln Ala  Leu Val Pro Pro Pro  Pro Pro Gly 

    1010                 1015                 1020             





Thr Pro  Tyr Glu Leu Ser Leu  His Gly Val Pro Pro  Gly Gly Lys 

    1025                 1030                 1035             





Pro Ser  Asp Pro Ile Ile Tyr  Gln Gly Ile Met Asp  Lys Asp Glu 

    1040                 1045                 1050             





Glu Lys  Pro Gly Lys Ser Ser  Gly Pro Pro Arg Leu  Gly Glu Leu 

    1055                 1060                 1065             





Thr Val  Thr Asp Arg Thr Ser  Asp Ser Leu Leu Leu  Arg Trp Thr 

    1070                 1075                 1080             





Val Pro  Glu Gly Glu Phe Asp  Ser Phe Val Ile Gln  Tyr Lys Asp 

    1085                 1090                 1095             





Arg Asp  Gly Gln Pro Gln Val  Val Pro Val Glu Gly  Pro Gln Arg 

    1100                 1105                 1110             





Ser Ala  Val Ile Thr Ser Leu  Asp Pro Gly Arg Lys  Tyr Lys Phe 

    1115                 1120                 1125             





Val Leu  Tyr Gly Phe Val Gly  Lys Lys Arg His Gly  Pro Leu Val 

    1130                 1135                 1140             





Ala Glu  Ala Lys Ile Leu Pro  Gln Ser Asp Pro Ser  Pro Gly Thr 

    1145                 1150                 1155             





Pro Pro  His Leu Gly Asn Leu  Trp Val Thr Asp Pro  Thr Pro Asp 

    1160                 1165                 1170             





Ser Leu  His Leu Ser Trp Thr  Val Pro Glu Gly Gln  Phe Asp Thr 

    1175                 1180                 1185             





Phe Met  Val Gln Tyr Arg Asp  Arg Asp Gly Arg Pro  Gln Val Val 

    1190                 1195                 1200             





Pro Val  Glu Gly Pro Glu Arg  Ser Phe Val Val Ser  Ser Leu Asp 

    1205                 1210                 1215             





Pro Asp  His Lys Tyr Arg Phe  Thr Leu Phe Gly Ile  Ala Asn Lys 

    1220                 1225                 1230             





Lys Arg  Tyr Gly Pro Leu Thr  Ala Asp Gly Thr Thr  Ala Pro Glu 

    1235                 1240                 1245             





Arg Lys  Glu Glu Pro Pro Arg  Pro Glu Phe Leu Glu  Gln Pro Leu 

    1250                 1255                 1260             





Leu Gly  Glu Leu Thr Val Thr  Gly Val Thr Pro Asp  Ser Leu Arg 

    1265                 1270                 1275             





Leu Ser  Trp Thr Val Ala Gln  Gly Pro Phe Asp Ser  Phe Met Val 

    1280                 1285                 1290             





Gln Tyr  Lys Asp Ala Gln Gly  Gln Pro Gln Ala Val  Pro Val Ala 

    1295                 1300                 1305             





Gly Asp  Glu Asn Glu Val Thr  Val Pro Gly Leu Asp  Pro Asp Arg 

    1310                 1315                 1320             





Lys Tyr  Lys Met Asn Leu Tyr  Gly Leu Arg Gly Arg  Gln Arg Val 

    1325                 1330                 1335             





Gly Pro  Glu Ser Val Val Ala  Lys Thr Ala Pro Gln  Glu Asp Val 

    1340                 1345                 1350             





Asp Glu  Thr Pro Ser Pro Thr  Glu Leu Gly Thr Glu  Ala Pro Glu 

    1355                 1360                 1365             





Ser Pro  Glu Glu Pro Leu Leu  Gly Glu Leu Thr Val  Thr Gly Ser 

    1370                 1375                 1380             





Ser Pro  Asp Ser Leu Ser Leu  Phe Trp Thr Val Pro  Gln Gly Ser 

    1385                 1390                 1395             





Phe Asp  Ser Phe Thr Val Gln  Tyr Lys Asp Arg Asp  Gly Arg Pro 

    1400                 1405                 1410             





Arg Ala  Val Arg Val Gly Gly  Lys Glu Ser Glu Val  Thr Val Gly 

    1415                 1420                 1425             





Gly Leu  Glu Pro Gly His Lys  Tyr Lys Met His Leu  Tyr Gly Leu 

    1430                 1435                 1440             





His Glu  Gly Gln Arg Val Gly  Pro Val Ser Ala Val  Gly Val Thr 

    1445                 1450                 1455             





Ala Pro  Gln Gln Glu Glu Thr  Pro Pro Ala Thr Glu  Ser Pro Leu 

    1460                 1465                 1470             





Glu Pro  Arg Leu Gly Glu Leu  Thr Val Thr Asp Val  Thr Pro Asn 

    1475                 1480                 1485             





Ser Val  Gly Leu Ser Trp Thr  Val Pro Glu Gly Gln  Phe Asp Ser 

    1490                 1495                 1500             





Phe Ile  Val Gln Tyr Lys Asp  Lys Asp Gly Gln Pro  Gln Val Val 

    1505                 1510                 1515             





Pro Val  Ala Ala Asp Gln Arg  Glu Val Thr Val Tyr  Asn Leu Glu 

    1520                 1525                 1530             





Pro Glu  Arg Lys Tyr Lys Met  Asn Met Tyr Gly Leu  His Asp Gly 

    1535                 1540                 1545             





Gln Arg  Met Gly Pro Leu Ser  Val Val Ile Val Thr  Ala Pro Leu 

    1550                 1555                 1560             





Pro Pro  Ala Pro Ala Thr Glu  Ala Ser Lys Pro Pro  Leu Glu Pro 

    1565                 1570                 1575             





Arg Leu  Gly Glu Leu Thr Val  Thr Asp Ile Thr Pro  Asp Ser Val 

    1580                 1585                 1590             





Gly Leu  Ser Trp Thr Val Pro  Glu Gly Glu Phe Asp  Ser Phe Val 

    1595                 1600                 1605             





Val Gln  Tyr Lys Asp Arg Asp  Gly Gln Pro Gln Val  Val Pro Val 

    1610                 1615                 1620             





Ala Ala  Asp Gln Arg Glu Val  Thr Ile Pro Asp Leu  Glu Pro Ser 

    1625                 1630                 1635             





Arg Lys  Tyr Lys Phe Leu Leu  Phe Gly Ile Gln Asp  Gly Lys Arg 

    1640                 1645                 1650             





Arg Ser  Pro Val Ser Val Glu  Ala Lys Thr Val Ala  Arg Gly Asp 

    1655                 1660                 1665             





Ala Ser  Pro Gly Ala Pro Pro  Arg Leu Gly Glu Leu  Trp Val Thr 

    1670                 1675                 1680             





Asp Pro  Thr Pro Asp Ser Leu  Arg Leu Ser Trp Thr  Val Pro Glu 

    1685                 1690                 1695             





Gly Gln  Phe Asp Ser Phe Val  Val Gln Phe Lys Asp  Lys Asp Gly 

    1700                 1705                 1710             





Pro Gln  Val Val Pro Val Glu  Gly His Glu Arg Ser  Val Thr Val 

    1715                 1720                 1725             





Thr Pro  Leu Asp Ala Gly Arg  Lys Tyr Arg Phe Leu  Leu Tyr Gly 

    1730                 1735                 1740             





Leu Leu  Gly Lys Lys Arg His  Gly Pro Leu Thr Ala  Asp Gly Thr 

    1745                 1750                 1755             





Thr Glu  Ala Arg Ser Ala Met  Asp Asp Thr Gly Thr  Lys Arg Pro 

    1760                 1765                 1770             





Pro Lys  Pro Arg Leu Gly Glu  Glu Leu Gln Val Thr  Thr Val Thr 

    1775                 1780                 1785             





Gln Asn  Ser Val Gly Leu Ser  Trp Thr Val Pro Glu  Gly Gln Phe 

    1790                 1795                 1800             





Asp Ser  Phe Val Val Gln Tyr  Lys Asp Arg Asp Gly  Gln Pro Gln 

    1805                 1810                 1815             





Val Val  Pro Val Glu Gly Ser  Leu Arg Glu Val Ser  Val Pro Gly 

    1820                 1825                 1830             





Leu Asp  Pro Ala His Arg Tyr  Lys Leu Leu Leu Tyr  Gly Leu His 

    1835                 1840                 1845             





His Gly  Lys Arg Val Gly Pro  Ile Ser Ala Val Ala  Ile Thr Ala 

    1850                 1855                 1860             





Gly Arg  Glu Glu Thr Glu Thr  Glu Thr Thr Ala Pro  Thr Pro Pro 

    1865                 1870                 1875             





Ala Pro  Glu Pro His Leu Gly  Glu Leu Thr Val Glu  Glu Ala Thr 

    1880                 1885                 1890             





Ser His  Thr Leu His Leu Ser  Trp Met Val Thr Glu  Gly Glu Phe 

    1895                 1900                 1905             





Asp Ser  Phe Glu Ile Gln Tyr  Thr Asp Arg Asp Gly  Gln Leu Gln 

    1910                 1915                 1920             





Met Val  Arg Ile Gly Gly Asp  Arg Asn Asp Ile Thr  Leu Ser Gly 

    1925                 1930                 1935             





Leu Glu  Ser Asp His Arg Tyr  Leu Val Thr Leu Tyr  Gly Phe Ser 

    1940                 1945                 1950             





Asp Gly  Lys His Val Gly Pro  Val His Val Glu Ala  Leu Thr Val 

    1955                 1960                 1965             





Pro Glu  Glu Glu Lys Pro Ser  Glu Pro Pro Thr Ala  Thr Pro Glu 

    1970                 1975                 1980             





Pro Pro  Ile Lys Pro Arg Leu  Gly Glu Leu Thr Val  Thr Asp Ala 

    1985                 1990                 1995             





Thr Pro  Asp Ser Leu Ser Leu  Ser Trp Thr Val Pro  Glu Gly Gln 

    2000                 2005                 2010             





Phe Asp  His Phe Leu Val Gln  Tyr Arg Asn Gly Asp  Gly Gln Pro 

    2015                 2020                 2025             





Lys Ala  Val Arg Val Pro Gly  His Glu Glu Gly Val  Thr Ile Ser 

    2030                 2035                 2040             





Gly Leu  Glu Pro Asp His Lys  Tyr Lys Met Asn Leu  Tyr Gly Phe 

    2045                 2050                 2055             





His Gly  Gly Gln Arg Met Gly  Pro Val Ser Val Val  Gly Val Thr 

    2060                 2065                 2070             





Ala Ala  Glu Glu Glu Thr Pro  Ser Pro Thr Glu Pro  Ser Met Glu 

    2075                 2080                 2085             





Ala Pro  Glu Pro Ala Glu Glu  Pro Leu Leu Gly Glu  Leu Thr Val 

    2090                 2095                 2100             





Thr Gly  Ser Ser Pro Asp Ser  Leu Ser Leu Ser Trp  Thr Val Pro 

    2105                 2110                 2115             





Gln Gly  Arg Phe Asp Ser Phe  Thr Val Gln Tyr Lys  Asp Arg Asp 

    2120                 2125                 2130             





Gly Arg  Pro Gln Val Val Arg  Val Gly Gly Glu Glu  Ser Glu Val 

    2135                 2140                 2145             





Thr Val  Gly Gly Leu Glu Pro  Gly Arg Lys Tyr Lys  Met His Leu 

    2150                 2155                 2160             





Tyr Gly  Leu His Glu Gly Arg  Arg Val Gly Pro Val  Ser Ala Val 

    2165                 2170                 2175             





Gly Val  Thr Ala Pro Glu Glu  Glu Ser Pro Asp Ala  Pro Leu Ala 

    2180                 2185                 2190             





Lys Leu  Arg Leu Gly Gln Met  Thr Val Arg Asp Ile  Thr Ser Asp 

    2195                 2200                 2205             





Ser Leu  Ser Leu Ser Trp Thr  Val Pro Glu Gly Gln  Phe Asp His 

    2210                 2215                 2220             





Phe Leu  Val Gln Phe Lys Asn  Gly Asp Gly Gln Pro  Lys Ala Val 

    2225                 2230                 2235             





Arg Val  Pro Gly His Glu Asp  Gly Val Thr Ile Ser  Gly Leu Glu 

    2240                 2245                 2250             





Pro Asp  His Lys Tyr Lys Met  Asn Leu Tyr Gly Phe  His Gly Gly 

    2255                 2260                 2265             





Gln Arg  Val Gly Pro Val Ser  Ala Val Gly Leu Thr  Ala Pro Gly 

    2270                 2275                 2280             





Lys Asp  Glu Glu Met Ala Pro  Ala Ser Thr Glu Pro  Pro Thr Pro 

    2285                 2290                 2295             





Glu Pro  Pro Ile Lys Pro Arg  Leu Glu Glu Leu Thr  Val Thr Asp 

    2300                 2305                 2310             





Ala Thr  Pro Asp Ser Leu Ser  Leu Ser Trp Thr Val  Pro Glu Gly 

    2315                 2320                 2325             





Gln Phe  Asp His Phe Leu Val  Gln Tyr Lys Asn Gly  Asp Gly Gln 

    2330                 2335                 2340             





Pro Lys  Ala Thr Arg Val Pro  Gly His Glu Asp Arg  Val Thr Ile 

    2345                 2350                 2355             





Ser Gly  Leu Glu Pro Asp Asn  Lys Tyr Lys Met Asn  Leu Tyr Gly 

    2360                 2365                 2370             





Phe His  Gly Gly Gln Arg Val  Gly Pro Val Ser Ala  Ile Gly Val 

    2375                 2380                 2385             





Thr Ala  Ala Glu Glu Glu Thr  Pro Ser Pro Thr Glu  Pro Ser Met 

    2390                 2395                 2400             





Glu Ala  Pro Glu Pro Pro Glu  Glu Pro Leu Leu Gly  Glu Leu Thr 

    2405                 2410                 2415             





Val Thr  Gly Ser Ser Pro Asp  Ser Leu Ser Leu Ser  Trp Thr Val 

    2420                 2425                 2430             





Pro Gln  Gly Arg Phe Asp Ser  Phe Thr Val Gln Tyr  Lys Asp Arg 

    2435                 2440                 2445             





Asp Gly  Arg Pro Gln Val Val  Arg Val Gly Gly Glu  Glu Ser Glu 

    2450                 2455                 2460             





Val Thr  Val Gly Gly Leu Glu  Pro Gly Arg Lys Tyr  Lys Met His 

    2465                 2470                 2475             





Leu Tyr  Gly Leu His Glu Gly  Arg Arg Val Gly Pro  Val Ser Thr 

    2480                 2485                 2490             





Val Gly  Val Thr Ala Pro Gln  Glu Asp Val Asp Glu  Thr Pro Ser 

    2495                 2500                 2505             





Pro Thr  Glu Pro Gly Thr Glu  Ala Pro Gly Pro Pro  Glu Glu Pro 

    2510                 2515                 2520             





Leu Leu  Gly Glu Leu Thr Val  Thr Gly Ser Ser Pro  Asp Ser Leu 

    2525                 2530                 2535             





Ser Leu  Ser Trp Thr Val Pro  Gln Gly Arg Phe Asp  Ser Phe Thr 

    2540                 2545                 2550             





Val Gln  Tyr Lys Asp Arg Asp  Gly Arg Pro Gln Ala  Val Arg Val 

    2555                 2560                 2565             





Gly Gly  Gln Glu Ser Lys Val  Thr Val Arg Gly Leu  Glu Pro Gly 

    2570                 2575                 2580             





Arg Lys  Tyr Lys Met His Leu  Tyr Gly Leu His Glu  Gly Arg Arg 

    2585                 2590                 2595             





Leu Gly  Pro Val Ser Ala Val  Gly Val Thr Glu Asp  Glu Ala Glu 

    2600                 2605                 2610             





Thr Thr  Gln Ala Val Pro Thr  Met Thr Pro Glu Pro  Pro Ile Lys 

    2615                 2620                 2625             





Pro Arg  Leu Gly Glu Leu Thr  Met Thr Asp Ala Thr  Pro Asp Ser 

    2630                 2635                 2640             





Leu Ser  Leu Ser Trp Thr Val  Pro Glu Gly Gln Phe  Asp His Phe 

    2645                 2650                 2655             





Leu Val  Gln Tyr Arg Asn Gly  Asp Gly Gln Pro Lys  Ala Val Arg 

    2660                 2665                 2670             





Val Pro  Gly His Glu Asp Gly  Val Thr Ile Ser Gly  Leu Glu Pro 

    2675                 2680                 2685             





Asp His  Lys Tyr Lys Met Asn  Leu Tyr Gly Phe His  Gly Gly Gln 

    2690                 2695                 2700             





Arg Val  Gly Pro Ile Ser Val  Ile Gly Val Thr Ala  Ala Glu Glu 

    2705                 2710                 2715             





Glu Thr  Pro Ser Pro Thr Glu  Leu Ser Thr Glu Ala  Pro Glu Pro 

    2720                 2725                 2730             





Pro Glu  Glu Pro Leu Leu Gly  Glu Leu Thr Val Thr  Gly Ser Ser 

    2735                 2740                 2745             





Pro Asp  Ser Leu Ser Leu Ser  Trp Thr Ile Pro Gln  Gly His Phe 

    2750                 2755                 2760             





Asp Ser  Phe Thr Val Gln Tyr  Lys Asp Arg Asp Gly  Arg Pro Gln 

    2765                 2770                 2775             





Val Met  Arg Val Arg Gly Glu  Glu Ser Glu Val Thr  Val Gly Gly 

    2780                 2785                 2790             





Leu Glu  Pro Gly Arg Lys Tyr  Lys Met His Leu Tyr  Gly Leu His 

    2795                 2800                 2805             





Glu Gly  Arg Arg Val Gly Pro  Val Ser Thr Val Gly  Val Thr Glu 

    2810                 2815                 2820             





Asp Glu  Ala Glu Thr Thr Gln  Ala Val Pro Thr Thr  Thr Pro Glu 

    2825                 2830                 2835             





Pro Pro  Asn Lys Pro Arg Leu  Gly Glu Leu Thr Val  Thr Asp Ala 

    2840                 2845                 2850             





Thr Pro  Asp Ser Leu Ser Leu  Ser Trp Met Val Pro  Glu Gly Gln 

    2855                 2860                 2865             





Phe Asp  His Phe Leu Val Gln  Tyr Arg Asn Gly Asp  Gly Gln Pro 

    2870                 2875                 2880             





Lys Val  Val Arg Val Pro Gly  His Glu Asp Gly Val  Thr Ile Ser 

    2885                 2890                 2895             





Gly Leu  Glu Pro Asp His Lys  Tyr Lys Met Asn Leu  Tyr Gly Phe 

    2900                 2905                 2910             





His Gly  Gly Gln Arg Val Gly  Pro Ile Ser Val Ile  Gly Val Thr 

    2915                 2920                 2925             





Ala Ala  Glu Glu Glu Thr Pro  Ala Pro Thr Glu Pro  Ser Thr Glu 

    2930                 2935                 2940             





Ala Pro  Glu Pro Pro Glu Glu  Pro Leu Leu Gly Glu  Leu Thr Val 

    2945                 2950                 2955             





Thr Gly  Ser Ser Pro Asp Ser  Leu Ser Leu Ser Trp  Thr Ile Pro 

    2960                 2965                 2970             





Gln Gly  Arg Phe Asp Ser Phe  Thr Val Gln Tyr Lys  Asp Arg Asp 

    2975                 2980                 2985             





Gly Arg  Pro Gln Val Val Arg  Val Arg Gly Glu Glu  Ser Glu Val 

    2990                 2995                 3000             





Thr Val  Gly Gly Leu Glu Pro  Gly Cys Lys Tyr Lys  Met His Leu 

    3005                 3010                 3015             





Tyr Gly  Leu His Glu Gly Gln  Arg Val Gly Pro Val  Ser Ala Val 

    3020                 3025                 3030             





Gly Val  Thr Ala Pro Lys Asp  Glu Ala Glu Thr Thr  Gln Ala Val 

    3035                 3040                 3045             





Pro Thr  Met Thr Pro Glu Pro  Pro Ile Lys Pro Arg  Leu Gly Glu 

    3050                 3055                 3060             





Leu Thr  Val Thr Asp Ala Thr  Pro Asp Ser Leu Ser  Leu Ser Trp 

    3065                 3070                 3075             





Met Val  Pro Glu Gly Gln Phe  Asp His Phe Leu Val  Gln Tyr Arg 

    3080                 3085                 3090             





Asn Gly  Asp Gly Gln Pro Lys  Ala Val Arg Val Pro  Gly His Glu 

    3095                 3100                 3105             





Asp Gly  Val Thr Ile Ser Gly  Leu Glu Pro Asp His  Lys Tyr Lys 

    3110                 3115                 3120             





Met Asn  Leu Tyr Gly Phe His  Gly Gly Gln Arg Val  Gly Pro Val 

    3125                 3130                 3135             





Ser Ala  Ile Gly Val Thr Glu  Glu Glu Thr Pro Ser  Pro Thr Glu 

    3140                 3145                 3150             





Pro Ser  Thr Glu Ala Pro Glu  Ala Pro Glu Glu Pro  Leu Leu Gly 

    3155                 3160                 3165             





Glu Leu  Thr Val Thr Gly Ser  Ser Pro Asp Ser Leu  Ser Leu Ser 

    3170                 3175                 3180             





Trp Thr  Val Pro Gln Gly Arg  Phe Asp Ser Phe Thr  Val Gln Tyr 

    3185                 3190                 3195             





Lys Asp  Arg Asp Gly Gln Pro  Gln Val Val Arg Val  Arg Gly Glu 

    3200                 3205                 3210             





Glu Ser  Glu Val Thr Val Gly  Gly Leu Glu Pro Gly  Arg Lys Tyr 

    3215                 3220                 3225             





Lys Met  His Leu Tyr Gly Leu  His Glu Gly Gln Arg  Val Gly Pro 

    3230                 3235                 3240             





Val Ser  Thr Val Gly Ile Thr  Ala Pro Leu Pro Thr  Pro Leu Pro 

    3245                 3250                 3255             





Val Glu  Pro Arg Leu Gly Glu  Leu Ala Val Ala Ala  Val Thr Ser 

    3260                 3265                 3270             





Asp Ser  Val Gly Leu Ser Trp  Thr Val Ala Gln Gly  Pro Phe Asp 

    3275                 3280                 3285             





Ser Phe  Leu Val Gln Tyr Arg  Asp Ala Gln Gly Gln  Pro Gln Ala 

    3290                 3295                 3300             





Val Pro  Val Ser Gly Asp Leu  Arg Ala Val Ala Val  Ser Gly Leu 

    3305                 3310                 3315             





Asp Pro  Ala Arg Lys Tyr Lys  Phe Leu Leu Phe Gly  Leu Gln Asn 

    3320                 3325                 3330             





Gly Lys  Arg His Gly Pro Val  Pro Val Glu Ala Arg  Thr Ala Pro 

    3335                 3340                 3345             





Asp Thr  Lys Pro Ser Pro Arg  Leu Gly Glu Leu Thr  Val Thr Asp 

    3350                 3355                 3360             





Ala Thr  Pro Asp Ser Val Gly  Leu Ser Trp Thr Val  Pro Glu Gly 

    3365                 3370                 3375             





Glu Phe  Asp Ser Phe Val Val  Gln Tyr Lys Asp Lys  Asp Gly Arg 

    3380                 3385                 3390             





Leu Gln  Val Val Pro Val Ala  Ala Asn Gln Arg Glu  Val Thr Val 

    3395                 3400                 3405             





Gln Gly  Leu Glu Pro Ser Arg  Lys Tyr Arg Phe Leu  Leu Tyr Gly 

    3410                 3415                 3420             





Leu Ser  Gly Arg Lys Arg Leu  Gly Pro Ile Ser Ala  Asp Ser Thr 

    3425                 3430                 3435             





Thr Ala  Pro Leu Glu Lys Glu  Leu Pro Pro His Leu  Gly Glu Leu 

    3440                 3445                 3450             





Thr Val  Ala Glu Glu Thr Ser  Ser Ser Leu Arg Leu  Ser Trp Thr 

    3455                 3460                 3465             





Val Ala  Gln Gly Pro Phe Asp  Ser Phe Val Val Gln  Tyr Arg Asp 

    3470                 3475                 3480             





Thr Asp  Gly Gln Pro Arg Ala  Val Pro Val Ala Ala  Asp Gln Arg 

    3485                 3490                 3495             





Thr Val  Thr Val Glu Asp Leu  Glu Pro Gly Lys Lys  Tyr Lys Phe 

    3500                 3505                 3510             





Leu Leu  Tyr Gly Leu Leu Gly  Gly Lys Arg Leu Gly  Pro Val Ser 

    3515                 3520                 3525             





Ala Leu  Gly Met Thr Ala Pro  Glu Glu Asp Thr Pro  Ala Pro Glu 

    3530                 3535                 3540             





Leu Ala  Pro Glu Ala Pro Glu  Pro Pro Glu Glu Pro  Arg Leu Gly 

    3545                 3550                 3555             





Val Leu  Thr Val Thr Asp Thr  Thr Pro Asp Ser Met  Arg Leu Ser 

    3560                 3565                 3570             





Trp Ser  Val Ala Gln Gly Pro  Phe Asp Ser Phe Val  Val Gln Tyr 

    3575                 3580                 3585             





Glu Asp  Thr Asn Gly Gln Pro  Gln Ala Leu Leu Val  Asp Gly Asp 

    3590                 3595                 3600             





Gln Ser  Lys Ile Leu Ile Ser  Gly Leu Glu Pro Ser  Thr Pro Tyr 

    3605                 3610                 3615             





Arg Phe  Leu Leu Tyr Gly Leu  His Glu Gly Lys Arg  Leu Gly Pro 

    3620                 3625                 3630             





Leu Ser  Ala Glu Gly Thr Thr  Gly Leu Ala Pro Ala  Gly Gln Thr 

    3635                 3640                 3645             





Ser Glu  Glu Ser Arg Pro Arg  Leu Ser Gln Leu Ser  Val Thr Asp 

    3650                 3655                 3660             





Val Thr  Thr Ser Ser Leu Arg  Leu Asn Trp Glu Ala  Pro Pro Gly 

    3665                 3670                 3675             





Ala Phe  Asp Ser Phe Leu Leu  Arg Phe Gly Val Pro  Ser Pro Ser 

    3680                 3685                 3690             





Thr Leu  Glu Pro His Pro Arg  Pro Leu Leu Gln Arg  Glu Leu Met 

    3695                 3700                 3705             





Val Pro  Gly Thr Arg His Ser  Ala Val Leu Arg Asp  Leu Arg Ser 

    3710                 3715                 3720             





Gly Thr  Leu Tyr Ser Leu Thr  Leu Tyr Gly Leu Arg  Gly Pro His 

    3725                 3730                 3735             





Lys Ala  Asp Ser Ile Gln Gly  Thr Ala Arg Thr Leu  Ser Pro Val 

    3740                 3745                 3750             





Leu Glu  Ser Pro Arg Asp Leu  Gln Phe Ser Glu Ile  Arg Glu Thr 

    3755                 3760                 3765             





Ser Ala  Lys Val Asn Trp Met  Pro Pro Pro Ser Arg  Ala Asp Ser 

    3770                 3775                 3780             





Phe Lys  Val Ser Tyr Gln Leu  Ala Asp Gly Gly Glu  Pro Gln Ser 

    3785                 3790                 3795             





Val Gln  Val Asp Gly Gln Ala  Arg Thr Gln Lys Leu  Gln Gly Leu 

    3800                 3805                 3810             





Ile Pro  Gly Ala Arg Tyr Glu  Val Thr Val Val Ser  Val Arg Gly 

    3815                 3820                 3825             





Phe Glu  Glu Ser Glu Pro Leu  Thr Gly Phe Leu Thr  Thr Val Pro 

    3830                 3835                 3840             





Asp Gly  Pro Thr Gln Leu Arg  Ala Leu Asn Leu Thr  Glu Gly Phe 

    3845                 3850                 3855             





Ala Val  Leu His Trp Lys Pro  Pro Gln Asn Pro Val  Asp Thr Tyr 

    3860                 3865                 3870             





Asp Val  Gln Val Thr Ala Pro  Gly Ala Pro Pro Leu  Gln Ala Glu 

    3875                 3880                 3885             





Thr Pro  Gly Ser Ala Val Asp  Tyr Pro Leu His Asp  Leu Val Leu 

    3890                 3895                 3900             





His Thr  Asn Tyr Thr Ala Thr  Val Arg Gly Leu Arg  Gly Pro Asn 

    3905                 3910                 3915             





Leu Thr  Ser Pro Ala Ser Ile  Thr Phe Thr Thr Gly  Leu Glu Ala 

    3920                 3925                 3930             





Pro Arg  Asp Leu Glu Ala Lys  Glu Val Thr Pro Arg  Thr Ala Leu 

    3935                 3940                 3945             





Leu Thr  Trp Thr Glu Pro Pro  Val Arg Pro Ala Gly  Tyr Leu Leu 

    3950                 3955                 3960             





Ser Phe  His Thr Pro Gly Gly  Gln Asn Gln Glu Ile  Leu Leu Pro 

    3965                 3970                 3975             





Gly Gly  Ile Thr Ser His Gln  Leu Leu Gly Leu Phe  Pro Ser Thr 

    3980                 3985                 3990             





Ser Tyr  Asn Ala Arg Leu Gln  Ala Met Trp Gly Gln  Ser Leu Leu 

    3995                 4000                 4005             





Pro Pro  Val Ser Thr Ser Phe  Thr Thr Gly Gly Leu  Arg Ile Pro 

    4010                 4015                 4020             





Phe Pro  Arg Asp Cys Gly Glu  Glu Met Gln Asn Gly  Ala Gly Ala 

    4025                 4030                 4035             





Ser Arg  Thr Ser Thr Ile Phe  Leu Asn Gly Asn Arg  Glu Arg Pro 

    4040                 4045                 4050             





Leu Asn  Val Phe Cys Asp Met  Glu Thr Asp Gly Gly  Gly Trp Leu 

    4055                 4060                 4065             





Val Phe  Gln Arg Arg Met Asp  Gly Gln Thr Asp Phe  Trp Arg Asp 

    4070                 4075                 4080             





Trp Glu  Asp Tyr Ala His Gly  Phe Gly Asn Ile Ser  Gly Glu Phe 

    4085                 4090                 4095             





Trp Leu  Gly Asn Glu Ala Leu  His Ser Leu Thr Gln  Ala Gly Asp 

    4100                 4105                 4110             





Tyr Ser  Met Arg Val Asp Leu  Arg Ala Gly Asp Glu  Ala Val Phe 

    4115                 4120                 4125             





Ala Gln  Tyr Asp Ser Phe His  Val Asp Ser Ala Ala  Glu Tyr Tyr 

    4130                 4135                 4140             





Arg Leu  His Leu Glu Gly Tyr  His Gly Thr Ala Gly  Asp Ser Met 

    4145                 4150                 4155             





Ser Tyr  His Ser Gly Ser Val  Phe Ser Ala Arg Asp  Arg Asp Pro 

    4160                 4165                 4170             





Asn Ser  Leu Leu Ile Ser Cys  Ala Val Ser Tyr Arg  Gly Ala Trp 

    4175                 4180                 4185             





Trp Tyr  Arg Asn Cys His Tyr  Ala Asn Leu Asn Gly  Leu Tyr Gly 

    4190                 4195                 4200             





Ser Thr  Val Asp His Gln Gly  Val Ser Trp Tyr His  Trp Lys Gly 

    4205                 4210                 4215             





Phe Glu  Phe Ser Val Pro Phe  Thr Glu Met Lys Leu  Arg Pro Arg 

    4220                 4225                 4230             





Asn Phe  Arg Ser Pro Ala Gly  Gly Gly 

    4235                 4240         





<210>  78

<211>  673

<212>  PRT

<213>  Homo sapiens



<400>  78



Met Arg Leu Ser Trp Ser Val Ala Gln Gly Pro Phe Asp Ser Phe Val 

1               5                   10                  15      





Val Gln Tyr Glu Asp Thr Asn Gly Gln Pro Gln Ala Leu Leu Val Asp 

            20                  25                  30          





Gly Asp Gln Ser Lys Ile Leu Ile Ser Gly Leu Glu Pro Ser Thr Pro 

        35                  40                  45              





Tyr Arg Phe Leu Leu Tyr Gly Leu His Glu Gly Lys Arg Leu Gly Pro 

    50                  55                  60                  





Leu Ser Ala Glu Gly Thr Thr Gly Leu Ala Pro Ala Gly Gln Thr Ser 

65                  70                  75                  80  





Glu Glu Ser Arg Pro Arg Leu Ser Gln Leu Ser Val Thr Asp Val Thr 

                85                  90                  95      





Thr Ser Ser Leu Arg Leu Asn Trp Glu Ala Pro Pro Gly Ala Phe Asp 

            100                 105                 110         





Ser Phe Leu Leu Arg Phe Gly Val Pro Ser Pro Ser Thr Leu Glu Pro 

        115                 120                 125             





His Pro Arg Pro Leu Leu Gln Arg Glu Leu Met Val Pro Gly Thr Arg 

    130                 135                 140                 





His Ser Ala Val Leu Arg Asp Leu Arg Ser Gly Thr Leu Tyr Ser Leu 

145                 150                 155                 160 





Thr Leu Tyr Gly Leu Arg Gly Pro His Lys Ala Asp Ser Ile Gln Gly 

                165                 170                 175     





Thr Ala Arg Thr Leu Ser Pro Val Leu Glu Ser Pro Arg Asp Leu Gln 

            180                 185                 190         





Phe Ser Glu Ile Arg Glu Thr Ser Ala Lys Val Asn Trp Met Pro Pro 

        195                 200                 205             





Pro Ser Arg Ala Asp Ser Phe Lys Val Ser Tyr Gln Leu Ala Asp Gly 

    210                 215                 220                 





Gly Glu Pro Gln Ser Val Gln Val Asp Gly Gln Ala Arg Thr Gln Lys 

225                 230                 235                 240 





Leu Gln Gly Leu Ile Pro Gly Ala Arg Tyr Glu Val Thr Val Val Ser 

                245                 250                 255     





Val Arg Gly Phe Glu Glu Ser Glu Pro Leu Thr Gly Phe Leu Thr Thr 

            260                 265                 270         





Val Pro Asp Gly Pro Thr Gln Leu Arg Ala Leu Asn Leu Thr Glu Gly 

        275                 280                 285             





Phe Ala Val Leu His Trp Lys Pro Pro Gln Asn Pro Val Asp Thr Tyr 

    290                 295                 300                 





Asp Val Gln Val Thr Ala Pro Gly Ala Pro Pro Leu Gln Ala Glu Thr 

305                 310                 315                 320 





Pro Gly Ser Ala Val Asp Tyr Pro Leu His Asp Leu Val Leu His Thr 

                325                 330                 335     





Asn Tyr Thr Ala Thr Val Arg Gly Leu Arg Gly Pro Asn Leu Thr Ser 

            340                 345                 350         





Pro Ala Ser Ile Thr Phe Thr Thr Gly Leu Glu Ala Pro Arg Asp Leu 

        355                 360                 365             





Glu Ala Lys Glu Val Thr Pro Arg Thr Ala Leu Leu Thr Trp Thr Glu 

    370                 375                 380                 





Pro Pro Val Arg Pro Ala Gly Tyr Leu Leu Ser Phe His Thr Pro Gly 

385                 390                 395                 400 





Gly Gln Asn Gln Glu Ile Leu Leu Pro Gly Gly Ile Thr Ser His Gln 

                405                 410                 415     





Leu Leu Gly Leu Phe Pro Ser Thr Ser Tyr Asn Ala Arg Leu Gln Ala 

            420                 425                 430         





Met Trp Gly Gln Ser Leu Leu Pro Pro Val Ser Thr Ser Phe Thr Thr 

        435                 440                 445             





Gly Gly Leu Arg Ile Pro Phe Pro Arg Asp Cys Gly Glu Glu Met Gln 

    450                 455                 460                 





Asn Gly Ala Gly Ala Ser Arg Thr Ser Thr Ile Phe Leu Asn Gly Asn 

465                 470                 475                 480 





Arg Glu Arg Pro Leu Asn Val Phe Cys Asp Met Glu Thr Asp Gly Gly 

                485                 490                 495     





Gly Trp Leu Val Phe Gln Arg Arg Met Asp Gly Gln Thr Asp Phe Trp 

            500                 505                 510         





Arg Asp Trp Glu Asp Tyr Ala His Gly Phe Gly Asn Ile Ser Gly Glu 

        515                 520                 525             





Phe Trp Leu Gly Asn Glu Ala Leu His Ser Leu Thr Gln Ala Gly Asp 

    530                 535                 540                 





Tyr Ser Met Arg Val Asp Leu Arg Ala Gly Asp Glu Ala Val Phe Ala 

545                 550                 555                 560 





Gln Tyr Asp Ser Phe His Val Asp Ser Ala Ala Glu Tyr Tyr Arg Leu 

                565                 570                 575     





His Leu Glu Gly Tyr His Gly Thr Ala Gly Asp Ser Met Ser Tyr His 

            580                 585                 590         





Ser Gly Ser Val Phe Ser Ala Arg Asp Arg Asp Pro Asn Ser Leu Leu 

        595                 600                 605             





Ile Ser Cys Ala Val Ser Tyr Arg Gly Ala Trp Trp Tyr Arg Asn Cys 

    610                 615                 620                 





His Tyr Ala Asn Leu Asn Gly Leu Tyr Gly Ser Thr Val Asp His Gln 

625                 630                 635                 640 





Gly Val Ser Trp Tyr His Trp Lys Gly Phe Glu Phe Ser Val Pro Phe 

                645                 650                 655     





Thr Glu Met Lys Leu Arg Pro Arg Asn Phe Arg Ser Pro Ala Gly Gly 

            660                 665                 670         





Gly 

    





<210>  79

<211>  353

<212>  PRT

<213>  Homo sapiens



<400>  79



Met Glu Lys Thr Leu Glu Thr Val Pro Leu Glu Arg Lys Lys Arg Glu 

1               5                   10                  15      





Lys Glu Gln Phe Arg Lys Leu Phe Ile Gly Gly Leu Ser Phe Glu Thr 

            20                  25                  30          





Thr Glu Glu Ser Leu Arg Asn Tyr Tyr Glu Gln Trp Gly Lys Leu Thr 

        35                  40                  45              





Asp Cys Val Val Met Arg Asp Pro Ala Ser Lys Arg Ser Arg Gly Phe 

    50                  55                  60                  





Gly Phe Val Thr Phe Ser Ser Met Ala Glu Val Asp Ala Ala Met Ala 

65                  70                  75                  80  





Ala Arg Pro His Ser Ile Asp Gly Arg Val Val Glu Pro Lys Arg Ala 

                85                  90                  95      





Val Ala Arg Glu Glu Ser Gly Lys Pro Gly Ala His Val Thr Val Lys 

            100                 105                 110         





Lys Leu Phe Val Gly Gly Ile Lys Glu Asp Thr Glu Glu His His Leu 

        115                 120                 125             





Arg Asp Tyr Phe Glu Glu Tyr Gly Lys Ile Asp Thr Ile Glu Ile Ile 

    130                 135                 140                 





Thr Asp Arg Gln Ser Gly Lys Lys Arg Gly Phe Gly Phe Val Thr Phe 

145                 150                 155                 160 





Asp Asp His Asp Pro Val Asp Lys Ile Val Leu Gln Lys Tyr His Thr 

                165                 170                 175     





Ile Asn Gly His Asn Ala Glu Val Arg Lys Ala Leu Ser Arg Gln Glu 

            180                 185                 190         





Met Gln Glu Val Gln Ser Ser Arg Ser Gly Arg Gly Gly Asn Phe Gly 

        195                 200                 205             





Phe Gly Asp Ser Arg Gly Gly Gly Gly Asn Phe Gly Pro Gly Pro Gly 

    210                 215                 220                 





Ser Asn Phe Arg Gly Gly Ser Asp Gly Tyr Gly Ser Gly Arg Gly Phe 

225                 230                 235                 240 





Gly Asp Gly Tyr Asn Gly Tyr Gly Gly Gly Pro Gly Gly Gly Asn Phe 

                245                 250                 255     





Gly Gly Ser Pro Gly Tyr Gly Gly Gly Arg Gly Gly Tyr Gly Gly Gly 

            260                 265                 270         





Gly Pro Gly Tyr Gly Asn Gln Gly Gly Gly Tyr Gly Gly Gly Tyr Asp 

        275                 280                 285             





Asn Tyr Gly Gly Gly Asn Tyr Gly Ser Gly Asn Tyr Asn Asp Phe Gly 

    290                 295                 300                 





Asn Tyr Asn Gln Gln Pro Ser Asn Tyr Gly Pro Met Lys Ser Gly Asn 

305                 310                 315                 320 





Phe Gly Gly Ser Arg Asn Met Gly Gly Pro Tyr Gly Gly Gly Asn Tyr 

                325                 330                 335     





Gly Pro Gly Gly Ser Gly Gly Ser Gly Gly Tyr Gly Gly Arg Ser Arg 

            340                 345                 350         





Tyr 

    





<210>  80

<211>  313

<212>  PRT

<213>  Homo sapiens



<400>  80



Met Glu Lys Thr Leu Glu Thr Val Pro Leu Glu Arg Lys Lys Arg Glu 

1               5                   10                  15      





Lys Glu Gln Phe Arg Lys Leu Phe Ile Gly Gly Leu Ser Phe Glu Thr 

            20                  25                  30          





Thr Glu Glu Ser Leu Arg Asn Tyr Tyr Glu Gln Trp Gly Lys Leu Thr 

        35                  40                  45              





Asp Cys Val Val Met Arg Asp Pro Ala Ser Lys Arg Ser Arg Gly Phe 

    50                  55                  60                  





Gly Phe Val Thr Phe Ser Ser Met Ala Glu Val Asp Ala Ala Met Ala 

65                  70                  75                  80  





Ala Arg Pro His Ser Ile Asp Gly Arg Val Val Glu Pro Lys Arg Ala 

                85                  90                  95      





Val Ala Arg Glu Glu Ser Gly Lys Pro Gly Ala His Val Thr Val Lys 

            100                 105                 110         





Lys Leu Phe Val Gly Gly Ile Lys Glu Asp Thr Glu Glu His His Leu 

        115                 120                 125             





Arg Asp Tyr Phe Glu Glu Tyr Gly Lys Ile Asp Thr Ile Glu Ile Ile 

    130                 135                 140                 





Thr Asp Arg Gln Ser Gly Lys Lys Arg Gly Phe Gly Phe Val Thr Phe 

145                 150                 155                 160 





Asp Asp His Asp Pro Val Asp Lys Ile Val Leu Gln Lys Tyr His Thr 

                165                 170                 175     





Ile Asn Gly His Asn Ala Glu Val Arg Lys Ala Leu Ser Arg Gln Glu 

            180                 185                 190         





Met Gln Glu Val Gln Ser Ser Arg Ser Gly Arg Gly Gly Asn Phe Gly 

        195                 200                 205             





Phe Gly Asp Ser Arg Gly Gly Gly Gly Asn Phe Gly Pro Gly Pro Gly 

    210                 215                 220                 





Ser Asn Phe Arg Gly Gly Ser Asp Gly Tyr Gly Ser Gly Arg Gly Phe 

225                 230                 235                 240 





Gly Asp Gly Tyr Asn Gly Tyr Gly Gly Gly Pro Gly Gly Asn Tyr Gly 

                245                 250                 255     





Ser Gly Asn Tyr Asn Asp Phe Gly Asn Tyr Asn Gln Gln Pro Ser Asn 

            260                 265                 270         





Tyr Gly Pro Met Lys Ser Gly Asn Phe Gly Gly Ser Arg Asn Met Gly 

        275                 280                 285             





Gly Pro Tyr Gly Gly Gly Asn Tyr Gly Pro Gly Gly Ser Gly Gly Ser 

    290                 295                 300                 





Gly Gly Tyr Gly Gly Arg Ser Arg Tyr 

305                 310             





<210>  81

<211>  1487

<212>  PRT

<213>  Homo sapiens



<400>  81



Met Ile Arg Leu Gly Ala Pro Gln Thr Leu Val Leu Leu Thr Leu Leu 

1               5                   10                  15      





Val Ala Ala Val Leu Arg Cys Gln Gly Gln Asp Val Gln Glu Ala Gly 

            20                  25                  30          





Ser Cys Val Gln Asp Gly Gln Arg Tyr Asn Asp Lys Asp Val Trp Lys 

        35                  40                  45              





Pro Glu Pro Cys Arg Ile Cys Val Cys Asp Thr Gly Thr Val Leu Cys 

    50                  55                  60                  





Asp Asp Ile Ile Cys Glu Asp Val Lys Asp Cys Leu Ser Pro Glu Ile 

65                  70                  75                  80  





Pro Phe Gly Glu Cys Cys Pro Ile Cys Pro Thr Asp Leu Ala Thr Ala 

                85                  90                  95      





Ser Gly Gln Pro Gly Pro Lys Gly Gln Lys Gly Glu Pro Gly Asp Ile 

            100                 105                 110         





Lys Asp Ile Val Gly Pro Lys Gly Pro Pro Gly Pro Gln Gly Pro Ala 

        115                 120                 125             





Gly Glu Gln Gly Pro Arg Gly Asp Arg Gly Asp Lys Gly Glu Lys Gly 

    130                 135                 140                 





Ala Pro Gly Pro Arg Gly Arg Asp Gly Glu Pro Gly Thr Pro Gly Asn 

145                 150                 155                 160 





Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly 

                165                 170                 175     





Gly Asn Phe Ala Ala Gln Met Ala Gly Gly Phe Asp Glu Lys Ala Gly 

            180                 185                 190         





Gly Ala Gln Leu Gly Val Met Gln Gly Pro Met Gly Pro Met Gly Pro 

        195                 200                 205             





Arg Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro Gln Gly Phe Gln 

    210                 215                 220                 





Gly Asn Pro Gly Glu Pro Gly Glu Pro Gly Val Ser Gly Pro Met Gly 

225                 230                 235                 240 





Pro Arg Gly Pro Pro Gly Pro Pro Gly Lys Pro Gly Asp Asp Gly Glu 

                245                 250                 255     





Ala Gly Lys Pro Gly Lys Ala Gly Glu Arg Gly Pro Pro Gly Pro Gln 

            260                 265                 270         





Gly Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Val Lys Gly 

        275                 280                 285             





His Arg Gly Tyr Pro Gly Leu Asp Gly Ala Lys Gly Glu Ala Gly Ala 

    290                 295                 300                 





Pro Gly Val Lys Gly Glu Ser Gly Ser Pro Gly Glu Asn Gly Ser Pro 

305                 310                 315                 320 





Gly Pro Met Gly Pro Arg Gly Leu Pro Gly Glu Arg Gly Arg Thr Gly 

                325                 330                 335     





Pro Ala Gly Ala Ala Gly Ala Arg Gly Asn Asp Gly Gln Pro Gly Pro 

            340                 345                 350         





Ala Gly Pro Pro Gly Pro Val Gly Pro Ala Gly Gly Pro Gly Phe Pro 

        355                 360                 365             





Gly Ala Pro Gly Ala Lys Gly Glu Ala Gly Pro Thr Gly Ala Arg Gly 

    370                 375                 380                 





Pro Glu Gly Ala Gln Gly Pro Arg Gly Glu Pro Gly Thr Pro Gly Ser 

385                 390                 395                 400 





Pro Gly Pro Ala Gly Ala Ser Gly Asn Pro Gly Thr Asp Gly Ile Pro 

                405                 410                 415     





Gly Ala Lys Gly Ser Ala Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly 

            420                 425                 430         





Phe Pro Gly Pro Arg Gly Pro Pro Gly Pro Gln Gly Ala Thr Gly Pro 

        435                 440                 445             





Leu Gly Pro Lys Gly Gln Thr Gly Glu Pro Gly Ile Ala Gly Phe Lys 

    450                 455                 460                 





Gly Glu Gln Gly Pro Lys Gly Glu Pro Gly Pro Ala Gly Pro Gln Gly 

465                 470                 475                 480 





Ala Pro Gly Pro Ala Gly Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu 

                485                 490                 495     





Pro Gly Gly Val Gly Pro Ile Gly Pro Pro Gly Glu Arg Gly Ala Pro 

            500                 505                 510         





Gly Asn Arg Gly Phe Pro Gly Gln Asp Gly Leu Ala Gly Pro Lys Gly 

        515                 520                 525             





Ala Pro Gly Glu Arg Gly Pro Ser Gly Leu Ala Gly Pro Lys Gly Ala 

    530                 535                 540                 





Asn Gly Asp Pro Gly Arg Pro Gly Glu Pro Gly Leu Pro Gly Ala Arg 

545                 550                 555                 560 





Gly Leu Thr Gly Arg Pro Gly Asp Ala Gly Pro Gln Gly Lys Val Gly 

                565                 570                 575     





Pro Ser Gly Ala Pro Gly Glu Asp Gly Arg Pro Gly Pro Pro Gly Pro 

            580                 585                 590         





Gln Gly Ala Arg Gly Gln Pro Gly Val Met Gly Phe Pro Gly Pro Lys 

        595                 600                 605             





Gly Ala Asn Gly Glu Pro Gly Lys Ala Gly Glu Lys Gly Leu Pro Gly 

    610                 615                 620                 





Ala Pro Gly Leu Arg Gly Leu Pro Gly Lys Asp Gly Glu Thr Gly Ala 

625                 630                 635                 640 





Ala Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly Glu Arg Gly Glu Gln 

                645                 650                 655     





Gly Ala Pro Gly Pro Ser Gly Phe Gln Gly Leu Pro Gly Pro Pro Gly 

            660                 665                 670         





Pro Pro Gly Glu Gly Gly Lys Pro Gly Asp Gln Gly Val Pro Gly Glu 

        675                 680                 685             





Ala Gly Ala Pro Gly Leu Val Gly Pro Arg Gly Glu Arg Gly Phe Pro 

    690                 695                 700                 





Gly Glu Arg Gly Ser Pro Gly Ala Gln Gly Leu Gln Gly Pro Arg Gly 

705                 710                 715                 720 





Leu Pro Gly Thr Pro Gly Thr Asp Gly Pro Lys Gly Ala Ser Gly Pro 

                725                 730                 735     





Ala Gly Pro Pro Gly Ala Gln Gly Pro Pro Gly Leu Gln Gly Met Pro 

            740                 745                 750         





Gly Glu Arg Gly Ala Ala Gly Ile Ala Gly Pro Lys Gly Asp Arg Gly 

        755                 760                 765             





Asp Val Gly Glu Lys Gly Pro Glu Gly Ala Pro Gly Lys Asp Gly Gly 

    770                 775                 780                 





Arg Gly Leu Thr Gly Pro Ile Gly Pro Pro Gly Pro Ala Gly Ala Asn 

785                 790                 795                 800 





Gly Glu Lys Gly Glu Val Gly Pro Pro Gly Pro Ala Gly Ser Ala Gly 

                805                 810                 815     





Ala Arg Gly Ala Pro Gly Glu Arg Gly Glu Thr Gly Pro Pro Gly Pro 

            820                 825                 830         





Ala Gly Phe Ala Gly Pro Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys 

        835                 840                 845             





Gly Glu Gln Gly Glu Ala Gly Gln Lys Gly Asp Ala Gly Ala Pro Gly 

    850                 855                 860                 





Pro Gln Gly Pro Ser Gly Ala Pro Gly Pro Gln Gly Pro Thr Gly Val 

865                 870                 875                 880 





Thr Gly Pro Lys Gly Ala Arg Gly Ala Gln Gly Pro Pro Gly Ala Thr 

                885                 890                 895     





Gly Phe Pro Gly Ala Ala Gly Arg Val Gly Pro Pro Gly Ser Asn Gly 

            900                 905                 910         





Asn Pro Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Lys Asp Gly Pro 

        915                 920                 925             





Lys Gly Ala Arg Gly Asp Ser Gly Pro Pro Gly Arg Ala Gly Glu Pro 

    930                 935                 940                 





Gly Leu Gln Gly Pro Ala Gly Pro Pro Gly Glu Lys Gly Glu Pro Gly 

945                 950                 955                 960 





Asp Asp Gly Pro Ser Gly Ala Glu Gly Pro Pro Gly Pro Gln Gly Leu 

                965                 970                 975     





Ala Gly Gln Arg Gly Ile Val Gly Leu Pro Gly Gln Arg Gly Glu Arg 

            980                 985                 990         





Gly Phe Pro Gly Leu Pro Gly Pro  Ser Gly Glu Pro Gly  Lys Gln Gly 

        995                 1000                 1005             





Ala Pro  Gly Ala Ser Gly Asp  Arg Gly Pro Pro Gly  Pro Val Gly 

    1010                 1015                 1020             





Pro Pro  Gly Leu Thr Gly Pro  Ala Gly Glu Pro Gly  Arg Glu Gly 

    1025                 1030                 1035             





Ser Pro  Gly Ala Asp Gly Pro  Pro Gly Arg Asp Gly  Ala Ala Gly 

    1040                 1045                 1050             





Val Lys  Gly Asp Arg Gly Glu  Thr Gly Ala Val Gly  Ala Pro Gly 

    1055                 1060                 1065             





Ala Pro  Gly Pro Pro Gly Ser  Pro Gly Pro Ala Gly  Pro Thr Gly 

    1070                 1075                 1080             





Lys Gln  Gly Asp Arg Gly Glu  Ala Gly Ala Gln Gly  Pro Met Gly 

    1085                 1090                 1095             





Pro Ser  Gly Pro Ala Gly Ala  Arg Gly Ile Gln Gly  Pro Gln Gly 

    1100                 1105                 1110             





Pro Arg  Gly Asp Lys Gly Glu  Ala Gly Glu Pro Gly  Glu Arg Gly 

    1115                 1120                 1125             





Leu Lys  Gly His Arg Gly Phe  Thr Gly Leu Gln Gly  Leu Pro Gly 

    1130                 1135                 1140             





Pro Pro  Gly Pro Ser Gly Asp  Gln Gly Ala Ser Gly  Pro Ala Gly 

    1145                 1150                 1155             





Pro Ser  Gly Pro Arg Gly Pro  Pro Gly Pro Val Gly  Pro Ser Gly 

    1160                 1165                 1170             





Lys Asp  Gly Ala Asn Gly Ile  Pro Gly Pro Ile Gly  Pro Pro Gly 

    1175                 1180                 1185             





Pro Arg  Gly Arg Ser Gly Glu  Thr Gly Pro Ala Gly  Pro Pro Gly 

    1190                 1195                 1200             





Asn Pro  Gly Pro Pro Gly Pro  Pro Gly Pro Pro Gly  Pro Gly Ile 

    1205                 1210                 1215             





Asp Met  Ser Ala Phe Ala Gly  Leu Gly Pro Arg Glu  Lys Gly Pro 

    1220                 1225                 1230             





Asp Pro  Leu Gln Tyr Met Arg  Ala Asp Gln Ala Ala  Gly Gly Leu 

    1235                 1240                 1245             





Arg Gln  His Asp Ala Glu Val  Asp Ala Thr Leu Lys  Ser Leu Asn 

    1250                 1255                 1260             





Asn Gln  Ile Glu Ser Ile Arg  Ser Pro Glu Gly Ser  Arg Lys Asn 

    1265                 1270                 1275             





Pro Ala  Arg Thr Cys Arg Asp  Leu Lys Leu Cys His  Pro Glu Trp 

    1280                 1285                 1290             





Lys Ser  Gly Asp Tyr Trp Ile  Asp Pro Asn Gln Gly  Cys Thr Leu 

    1295                 1300                 1305             





Asp Ala  Met Lys Val Phe Cys  Asn Met Glu Thr Gly  Glu Thr Cys 

    1310                 1315                 1320             





Val Tyr  Pro Asn Pro Ala Asn  Val Pro Lys Lys Asn  Trp Trp Ser 

    1325                 1330                 1335             





Ser Lys  Ser Lys Glu Lys Lys  His Ile Trp Phe Gly  Glu Thr Ile 

    1340                 1345                 1350             





Asn Gly  Gly Phe His Phe Ser  Tyr Gly Asp Asp Asn  Leu Ala Pro 

    1355                 1360                 1365             





Asn Thr  Ala Asn Val Gln Met  Thr Phe Leu Arg Leu  Leu Ser Thr 

    1370                 1375                 1380             





Glu Gly  Ser Gln Asn Ile Thr  Tyr His Cys Lys Asn  Ser Ile Ala 

    1385                 1390                 1395             





Tyr Leu  Asp Glu Ala Ala Gly  Asn Leu Lys Lys Ala  Leu Leu Ile 

    1400                 1405                 1410             





Gln Gly  Ser Asn Asp Val Glu  Ile Arg Ala Glu Gly  Asn Ser Arg 

    1415                 1420                 1425             





Phe Thr  Tyr Thr Ala Leu Lys  Asp Gly Cys Thr Lys  His Thr Gly 

    1430                 1435                 1440             





Lys Trp  Gly Lys Thr Val Ile  Glu Tyr Arg Ser Gln  Lys Thr Ser 

    1445                 1450                 1455             





Arg Leu  Pro Ile Ile Asp Ile  Ala Pro Met Asp Ile  Gly Gly Pro 

    1460                 1465                 1470             





Glu Gln  Glu Phe Gly Val Asp  Ile Gly Pro Val Cys  Phe Leu 

    1475                 1480                 1485         





<210>  82

<211>  279

<212>  PRT

<213>  Aegilops tauschii



<400>  82



Met Lys Thr Phe Leu Ile Leu Ala Leu Leu Ala Ile Val Ala Thr Thr 

1               5                   10                  15      





Ala Thr Thr Ala Val Arg Val Pro Val Pro Gln Leu Gln Pro Gln Asn 

            20                  25                  30          





Pro Ser Gln Gln Gln Pro Gln Glu Gln Val Pro Leu Val Gln Gln Gln 

        35                  40                  45              





Gln Phe Leu Gly Gln Gln Gln Pro Phe Pro Pro Gln Gln Pro Tyr Pro 

    50                  55                  60                  





Gln Pro Gln Pro Phe Pro Ser Gln Gln Pro Tyr Leu Gln Leu Gln Pro 

65                  70                  75                  80  





Phe Pro Gln Pro Gln Leu Pro Tyr Ser Gln Pro Gln Pro Phe Arg Pro 

                85                  90                  95      





Gln Gln Pro Tyr Pro Gln Pro Gln Pro Gln Tyr Ser Gln Pro Gln Glu 

            100                 105                 110         





Pro Ile Ser Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ile Leu 

        115                 120                 125             





Gln Gln Ile Leu Gln Gln Gln Leu Ile Pro Cys Met Asp Val Val Leu 

    130                 135                 140                 





Gln Gln His Asn Ile Ala His Gly Arg Ser Gln Val Leu Gln Gln Ser 

145                 150                 155                 160 





Thr Tyr Gln Leu Leu Gln Glu Leu Cys Cys Gln His Leu Trp Gln Ile 

                165                 170                 175     





Pro Glu Gln Ser Gln Cys Gln Ala Ile Gln Asn Val Val His Ala Ile 

            180                 185                 190         





Ile Leu His Gln Gln Gln Lys Gln Gln Gln Gln Pro Ser Ser Gln Val 

        195                 200                 205             





Ser Phe Gln Gln Pro Leu Gln Gln Tyr Pro Leu Gly Gln Gly Ser Phe 

    210                 215                 220                 





Arg Pro Ser Gln Gln Asn Pro Gln Asp Gln Gly Ser Val Gln Pro Gln 

225                 230                 235                 240 





Gln Leu Pro Gln Phe Glu Glu Ile Arg Asn Leu Ala Leu Gln Thr Leu 

                245                 250                 255     





Pro Ala Met Cys Asn Val Tyr Ile Pro Pro Tyr Cys Thr Ile Ala Pro 

            260                 265                 270         





Phe Gly Ile Phe Gly Thr Asn 

        275                 





<210>  83

<211>  280

<212>  PRT

<213>  Aegilops tauschii



<400>  83



Met Lys Thr Phe Leu Ile Leu Ala Leu Leu Ala Ile Val Ala Thr Thr 

1               5                   10                  15      





Ala Thr Ile Ala Val Arg Val Pro Val Pro Gln Leu Gln Pro Gln Asn 

            20                  25                  30          





Pro Ser Gln Gln Gln Pro Gln Glu Gln Val Pro Leu Val Gln Gln Gln 

        35                  40                  45              





Gln Phe Pro Gly Gln Gln Gln Pro Phe Pro Pro Gln Gln Pro Tyr Pro 

    50                  55                  60                  





Gln Pro Gln Pro Phe Pro Ser Gln Gln Pro Tyr Leu Gln Leu Gln Pro 

65                  70                  75                  80  





Phe Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro Gln Pro Phe Arg Pro 

                85                  90                  95      





Gln Gln Pro Tyr Pro Gln Pro Gln Pro Gln Tyr Ser Gln Pro Gln Gln 

            100                 105                 110         





Pro Ile Ser Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 

        115                 120                 125             





Gln Gln Ile Leu Gln Gln Ile Leu Gln Gln Gln Leu Ile Pro Cys Arg 

    130                 135                 140                 





Asp Val Val Leu Gln Gln His Asn Val Ala His Gly Ser Ser Gln Val 

145                 150                 155                 160 





Leu Gln Gln Ser Thr Tyr Gln Leu Val Gln Gln Leu Cys Cys Gln Gln 

                165                 170                 175     





Leu Trp Gln Ile Pro Glu Gln Ser Arg Cys Gln Ala Ile His Asn Val 

            180                 185                 190         





Val His Ala Ile Ile Leu His Gln Gln Gln Gln Gln Pro Leu Ser Gln 

        195                 200                 205             





Val Ser Phe Gln Gln Pro Gln Gln Gln Tyr Pro Ser Gly Gln Gly Ser 

    210                 215                 220                 





Phe Gln Pro Ser Gln Gln Asn Pro Gln Ala Gln Gly Ser Val Gln Pro 

225                 230                 235                 240 





Gln Gln Leu Pro Gln Phe Glu Glu Ile Arg Asn Leu Ala Leu Glu Thr 

                245                 250                 255     





Leu Pro Ala Met Cys Asn Val Tyr Ile Pro Pro Tyr Cys Thr Ile Ala 

            260                 265                 270         





Pro Gly Gly Ile Phe Gly Thr Asn 

        275                 280 





<210>  84

<211>  201

<212>  PRT

<213>  Aegilops tauschii



<400>  84



Pro His Gln Pro Phe Ser Gln Gln Pro Gln Gln Thr Phe Pro Gln Pro 

1               5                   10                  15      





Gln Gln Thr Phe Pro His Gln Pro Gln Gln Gln Phe Pro Gln Pro Gln 

            20                  25                  30          





Gln Pro Gln Gln Gln Phe Leu Gln Pro Gln Gln Pro Phe Pro Gln Gln 

        35                  40                  45              





Pro Gln Gln Pro Tyr Pro Gln Gln Pro Gln Gln Pro Phe Pro Gln Thr 

    50                  55                  60                  





Gln Gln Pro Gln Gln Leu Phe Pro Gln Ser Gln Gln Pro Gln Gln Gln 

65                  70                  75                  80  





Phe Ser Gln Pro Gln Gln Gln Phe Pro Gln Pro Gln Gln Pro Gln Gln 

                85                  90                  95      





Ser Phe Pro Gln Gln Gln Pro Pro Phe Ile Gln Pro Ser Leu Gln Gln 

            100                 105                 110         





Gln Val Asn Pro Cys Lys Asn Phe Leu Leu Gln Gln Cys Lys Pro Val 

        115                 120                 125             





Ser Leu Val Ser Ser Leu Trp Ser Met Ile Trp Pro Gln Ser Asp Cys 

    130                 135                 140                 





Gln Val Met Arg Gln Gln Cys Cys Gln Gln Leu Ala Gln Ile Pro Gln 

145                 150                 155                 160 





Gln Leu Gln Cys Ala Ala Ile His Thr Val Ile His Ser Ile Ile Met 

                165                 170                 175     





Gln Gln Glu Gln Gln Glu Gln Gln Gln Gly Met His Ile Leu Leu Pro 

            180                 185                 190         





Leu Tyr Gln Gln Gln Gln Val Gly Gln 

        195                 200     





<210>  85

<211>  157

<212>  PRT

<213>  Homo sapiens



<400>  85



Met Glu Ile Pro Val Pro Val Gln Pro Ser Trp Leu Arg Arg Ala Ser 

1               5                   10                  15      





Ala Pro Leu Pro Gly Leu Ser Ala Pro Gly Arg Leu Phe Asp Gln Arg 

            20                  25                  30          





Phe Gly Glu Gly Leu Leu Glu Ala Glu Leu Ala Ala Leu Cys Pro Thr 

        35                  40                  45              





Thr Leu Ala Pro Tyr Tyr Leu Arg Ala Pro Ser Val Ala Leu Pro Val 

    50                  55                  60                  





Pro Thr Asp Pro Gly His Phe Ser Val Leu Leu Asp Val Lys His Phe 

65                  70                  75                  80  





Ser Pro Glu Glu Ile Ala Val Lys Val Val Gly Glu His Val Glu Val 

                85                  90                  95      





His Ala Arg His Glu Glu Arg Pro Asp Glu His Gly Phe Val Ala Arg 

            100                 105                 110         





Glu Phe His Arg Arg Tyr Arg Leu Pro Pro Gly Val Asp Pro Ala Ala 

        115                 120                 125             





Val Thr Ser Ala Leu Ser Pro Glu Gly Val Leu Ser Ile Gln Ala Ala 

    130                 135                 140                 





Pro Ala Ser Ala Gln Ala Pro Pro Pro Ala Ala Ala Lys 

145                 150                 155         





<210>  86

<211>  163

<212>  PRT

<213>  Homo sapiens



<400>  86



Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 

1               5                   10                  15      





Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 

            20                  25                  30          





Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 

        35                  40                  45              





Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 

    50                  55                  60                  





Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 

65                  70                  75                  80  





Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 

                85                  90                  95      





Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 

            100                 105                 110         





Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 

        115                 120                 125             





Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 

    130                 135                 140                 





Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 

145                 150                 155                 160 





Pro Pro Arg 

            





<210>  87

<211>  164

<212>  PRT

<213>  Homo sapiens



<400>  87



Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 

1               5                   10                  15      





Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 

            20                  25                  30          





Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 

        35                  40                  45              





Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 

    50                  55                  60                  





Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 

65                  70                  75                  80  





Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 

                85                  90                  95      





Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 

            100                 105                 110         





Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 

        115                 120                 125             





Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 

    130                 135                 140                 





Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 

145                 150                 155                 160 





Leu Pro Pro Arg 

                





<210>  88

<211>  123

<212>  PRT

<213>  Homo sapiens



<400>  88



Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 

1               5                   10                  15      





Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 

            20                  25                  30          





Asp Asn Ala Val Asn Leu Ser Trp Lys His Leu Cys Pro Ser Pro Leu 

        35                  40                  45              





Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 

    50                  55                  60                  





Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 

65                  70                  75                  80  





Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 

                85                  90                  95      





Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 

            100                 105                 110         





Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 

        115                 120             





<210>  89

<211>  101

<212>  PRT

<213>  Homo sapiens



<400>  89



Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 

1               5                   10                  15      





Thr Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 

            20                  25                  30          





Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 

        35                  40                  45              





Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 

    50                  55                  60                  





Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 

65                  70                  75                  80  





Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 

                85                  90                  95      





Ala Ala Tyr Arg Ser 

            100     





<210>  90

<211>  220

<212>  PRT

<213>  Homo sapiens



<400>  90



Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 

1               5                   10                  15      





Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 

            20                  25                  30          





Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 

        35                  40                  45              





Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 

    50                  55                  60                  





Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 

65                  70                  75                  80  





Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 

                85                  90                  95      





Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 

            100                 105                 110         





Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 

        115                 120                 125             





Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 

    130                 135                 140                 





Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 

145                 150                 155                 160 





Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 

                165                 170                 175     





Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 

            180                 185                 190         





Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 

        195                 200                 205             





Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 

    210                 215                 220 





<210>  91

<211>  255

<212>  PRT

<213>  Homo sapiens



<400>  91



Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 

1               5                   10                  15      





Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 

            20                  25                  30          





Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 

        35                  40                  45              





Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 

    50                  55                  60                  





Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 

65                  70                  75                  80  





Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 

                85                  90                  95      





Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 

            100                 105                 110         





Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 

        115                 120                 125             





Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 

    130                 135                 140                 





Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 

145                 150                 155                 160 





Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 

                165                 170                 175     





Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 

            180                 185                 190         





Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 

        195                 200                 205             





Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 

    210                 215                 220                 





Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 

225                 230                 235                 240 





Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 

                245                 250                 255 





<210>  92

<211>  199

<212>  PRT

<213>  Homo sapiens



<400>  92



Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu Arg Ile Lys 

1               5                   10                  15      





Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 

            20                  25                  30          





Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 

        35                  40                  45              





Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 

    50                  55                  60                  





Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu 

65                  70                  75                  80  





Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 

                85                  90                  95      





Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 

            100                 105                 110         





Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu 

        115                 120                 125             





His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro 

    130                 135                 140                 





Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu 

145                 150                 155                 160 





Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro 

                165                 170                 175     





Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser 

            180                 185                 190         





Arg Leu Thr Asp Val Thr Leu 

        195                 





<210>  93

<211>  277

<212>  PRT

<213>  Homo sapiens



<400>  93



Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 

1               5                   10                  15      





Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 

            20                  25                  30          





Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 

        35                  40                  45              





Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 

    50                  55                  60                  





Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 

65                  70                  75                  80  





Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 

                85                  90                  95      





Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 

            100                 105                 110         





Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 

        115                 120                 125             





Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 

    130                 135                 140                 





Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 

145                 150                 155                 160 





Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 

                165                 170                 175     





Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 

            180                 185                 190         





Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 

        195                 200                 205             





Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val 

    210                 215                 220                 





Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 

225                 230                 235                 240 





Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 

                245                 250                 255     





Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 

            260                 265                 270         





Thr Leu Ala Lys Ile 

        275         





<210>  94

<211>  184

<212>  PRT

<213>  Homo sapiens



<400>  94



Met Ala Pro Leu Leu Pro Ile Arg Thr Leu Pro Leu Ile Leu Ile Leu 

1               5                   10                  15      





Leu Ala Leu Leu Ser Pro Gly Ala Ala Asp Phe Asn Ile Ser Ser Leu 

            20                  25                  30          





Ser Gly Leu Leu Ser Pro Ala Leu Thr Glu Ser Leu Leu Val Ala Leu 

        35                  40                  45              





Pro Pro Cys His Leu Thr Gly Gly Asn Ala Thr Leu Met Val Arg Arg 

    50                  55                  60                  





Ala Asn Asp Ser Lys Val Val Thr Ser Ser Phe Val Val Pro Pro Cys 

65                  70                  75                  80  





Arg Gly Arg Arg Glu Leu Val Ser Val Val Asp Ser Gly Ala Gly Phe 

                85                  90                  95      





Thr Val Thr Arg Leu Ser Ala Tyr Gln Val Thr Asn Leu Val Pro Gly 

            100                 105                 110         





Thr Lys Phe Tyr Ile Ser Tyr Leu Val Lys Lys Gly Thr Ala Thr Glu 

        115                 120                 125             





Ser Ser Arg Glu Ile Pro Met Ser Thr Leu Pro Arg Arg Asn Met Glu 

    130                 135                 140                 





Ser Ile Gly Leu Gly Met Ala Arg Thr Gly Gly Met Val Val Ile Thr 

145                 150                 155                 160 





Val Leu Leu Ser Val Ala Met Phe Leu Leu Val Leu Gly Phe Ile Ile 

                165                 170                 175     





Ala Leu Ala Leu Gly Ser Arg Lys 

            180                 





<210>  95

<211>  273

<212>  PRT

<213>  Homo sapiens



<400>  95



Met Ala Ser Ala Ala Ala Ala Glu Ala Glu Lys Gly Ser Pro Val Val 

1               5                   10                  15      





Val Gly Leu Leu Val Val Gly Asn Ile Ile Ile Leu Leu Ser Gly Leu 

            20                  25                  30          





Ser Leu Phe Ala Glu Thr Ile Trp Val Thr Ala Asp Gln Tyr Arg Val 

        35                  40                  45              





Tyr Pro Leu Met Gly Val Ser Gly Lys Asp Asp Val Phe Ala Gly Ala 

    50                  55                  60                  





Trp Ile Ala Ile Phe Cys Gly Phe Ser Phe Phe Met Val Ala Ser Phe 

65                  70                  75                  80  





Gly Val Gly Ala Ala Leu Cys Arg Arg Arg Ser Met Val Leu Thr Tyr 

                85                  90                  95      





Leu Val Leu Met Leu Ile Val Tyr Ile Phe Glu Cys Ala Ser Cys Ile 

            100                 105                 110         





Thr Ser Tyr Thr His Arg Asp Tyr Met Val Ser Asn Pro Ser Leu Ile 

        115                 120                 125             





Thr Lys Gln Met Leu Thr Phe Tyr Ser Ala Asp Thr Asp Gln Gly Gln 

    130                 135                 140                 





Glu Leu Thr Arg Leu Trp Asp Arg Val Met Ile Glu Gln Glu Cys Cys 

145                 150                 155                 160 





Gly Thr Ser Gly Pro Met Asp Trp Val Asn Phe Thr Ser Ala Phe Arg 

                165                 170                 175     





Ala Ala Thr Pro Glu Val Val Phe Pro Trp Pro Pro Leu Cys Cys Arg 

            180                 185                 190         





Arg Thr Gly Asn Phe Ile Pro Leu Asn Glu Glu Gly Cys Arg Leu Gly 

        195                 200                 205             





His Met Asp Tyr Leu Phe Thr Lys Ala Gly Val Gln Trp His Asn Leu 

    210                 215                 220                 





Ser Ser Leu Gln Arg Leu Pro Pro Gly Phe Lys Gly Phe Ser His Leu 

225                 230                 235                 240 





Ser Phe Gln Ser Ser Trp Asp Tyr Arg Ala Ala Ser Asn Thr Ser Ala 

                245                 250                 255     





Thr Pro Ser Thr Ala Thr Arg Gly Val Ser Arg Gly Leu Gly Leu Pro 

            260                 265                 270         





Ser 

    





<210>  96

<211>  258

<212>  PRT

<213>  Homo sapiens



<400>  96



Met Ala Ser Ala Ala Ala Ala Glu Ala Glu Lys Gly Ser Pro Val Val 

1               5                   10                  15      





Val Gly Leu Leu Val Val Gly Asn Ile Ile Ile Leu Leu Ser Gly Leu 

            20                  25                  30          





Ser Leu Phe Ala Glu Thr Ile Trp Val Thr Ala Asp Gln Tyr Arg Val 

        35                  40                  45              





Tyr Pro Leu Met Gly Val Ser Gly Lys Asp Asp Val Phe Ala Gly Ala 

    50                  55                  60                  





Trp Ile Ala Ile Phe Cys Gly Phe Ser Phe Phe Met Val Ala Ser Phe 

65                  70                  75                  80  





Gly Val Gly Ala Ala Leu Cys Arg Arg Arg Ser Met Val Leu Thr Tyr 

                85                  90                  95      





Leu Val Leu Met Leu Ile Val Tyr Ile Phe Glu Cys Ala Ser Cys Ile 

            100                 105                 110         





Thr Ser Tyr Thr His Arg Asp Tyr Met Val Ser Asn Pro Ser Leu Ile 

        115                 120                 125             





Thr Lys Gln Met Leu Thr Phe Tyr Ser Ala Asp Thr Asp Gln Gly Gln 

    130                 135                 140                 





Glu Leu Thr Arg Leu Trp Asp Arg Val Met Ile Glu Gln Glu Cys Cys 

145                 150                 155                 160 





Gly Thr Ser Gly Pro Met Asp Trp Val Asn Phe Thr Ser Ala Phe Arg 

                165                 170                 175     





Ala Ala Thr Pro Glu Val Val Phe Pro Trp Pro Pro Leu Cys Cys Arg 

            180                 185                 190         





Arg Thr Gly Asn Phe Ile Pro Leu Asn Glu Glu Gly Cys Arg Leu Gly 

        195                 200                 205             





His Met Asp Tyr Leu Phe Thr Lys Gly Cys Phe Glu His Ile Gly His 

    210                 215                 220                 





Ala Ile Asp Ser Tyr Thr Trp Gly Ile Ser Trp Phe Gly Phe Ala Ile 

225                 230                 235                 240 





Leu Met Trp Thr Leu Pro Val Met Leu Ile Ala Met Tyr Phe Tyr Thr 

                245                 250                 255     





Met Leu 

        





<210>  97

<211>  245

<212>  PRT

<213>  Homo sapiens



<400>  97



Met Lys Gln Ser Phe Pro Leu Phe Leu Thr Pro Ser Pro Trp Lys Thr 

1               5                   10                  15      





Thr Val Leu Leu Leu Tyr Met Arg Ile Cys Tyr Val Pro Ser Tyr Lys 

            20                  25                  30          





Trp Asn Tyr Ser Ile Gly Leu Ile Tyr Leu Gly Ile Val Ser Glu Leu 

        35                  40                  45              





Pro His Met Val Gly Ile Gly Gln Asn Ser Ser Phe Asn Ser Trp Met 

    50                  55                  60                  





Glu Ser Gln Phe Leu His Pro Ser Met Glu Pro Gly Gln Trp Leu Pro 

65                  70                  75                  80  





Tyr Ile Thr Ile Phe Arg Phe Thr His Ile Ile Arg Cys Val Arg Ile 

                85                  90                  95      





Ser Phe Leu Phe Asn Ile Pro Trp Tyr Gly Tyr Pro His Phe Val Cys 

            100                 105                 110         





His Ser Ser Val Ser Gly His Leu Gly Tyr Phe Tyr Leu Leu Leu Leu 

        115                 120                 125             





Trp Leu Val Cys Cys Glu His Arg Cys Thr Asn Ile Cys Ser Arg Gln 

    130                 135                 140                 





Thr Ser Phe Lys Arg Leu Phe Leu Lys Lys Tyr Val Ser Tyr Asn Ile 

145                 150                 155                 160 





Phe Leu Leu Cys Val Glu Ser Asp Ile Ser Ile Asp Leu Glu Gly Tyr 

                165                 170                 175     





Gly Met Gly Cys Thr Asn Ile Cys Ser Arg Gln Thr Ser Phe Lys Arg 

            180                 185                 190         





Leu Phe Lys Arg Lys Tyr Arg Cys Leu Leu Asn Met Phe Leu Val Met 

        195                 200                 205             





Asn Val Glu Ser Gly Thr Asn Arg Tyr Met Glu Val Arg Arg Ala Trp 

    210                 215                 220                 





Arg Gly Ser Lys Trp Glu Asp Glu Glu Asn Trp Leu Gly Ile Asp Val 

225                 230                 235                 240 





Tyr Phe Glu Asp Arg 

                245 





<210>  98

<211>  114

<212>  PRT

<213>  Homo sapiens



<400>  98



Met Ala Gly Leu Ala Leu Gln Pro Gly Thr Ala Leu Leu Cys Tyr Ser 

1               5                   10                  15      





Cys Lys Ala Gln Val Ser Asn Glu Asp Cys Leu Gln Val Glu Asn Cys 

            20                  25                  30          





Thr Gln Leu Gly Glu Gln Cys Trp Thr Ala Arg Ile Arg Ala Val Gly 

        35                  40                  45              





Leu Leu Thr Val Ile Ser Lys Gly Cys Ser Leu Asn Cys Val Asp Asp 

    50                  55                  60                  





Ser Gln Asp Tyr Tyr Val Gly Lys Lys Asn Ile Thr Cys Cys Asp Thr 

65                  70                  75                  80  





Asp Leu Cys Asn Ala Ser Gly Ala His Ala Leu Gln Pro Ala Ala Ala 

                85                  90                  95      





Ile Leu Ala Leu Leu Pro Ala Leu Gly Leu Leu Leu Trp Gly Pro Gly 

            100                 105                 110         





Gln Leu 

        





<210>  99

<211>  386

<212>  PRT

<213>  Homo sapiens



<400>  99



Met Arg Ala Ala Pro Leu Leu Leu Ala Arg Ala Ala Ser Leu Ser Leu 

1               5                   10                  15      





Gly Phe Leu Phe Leu Leu Phe Phe Trp Leu Asp Arg Ser Val Leu Ala 

            20                  25                  30          





Lys Glu Leu Lys Phe Val Thr Leu Val Phe Arg His Gly Asp Arg Ser 

        35                  40                  45              





Pro Ile Asp Thr Phe Pro Thr Asp Pro Ile Lys Glu Ser Ser Trp Pro 

    50                  55                  60                  





Gln Gly Phe Gly Gln Leu Thr Gln Leu Gly Met Glu Gln His Tyr Glu 

65                  70                  75                  80  





Leu Gly Glu Tyr Ile Arg Lys Arg Tyr Arg Lys Phe Leu Asn Glu Ser 

                85                  90                  95      





Tyr Lys His Glu Gln Val Tyr Ile Arg Ser Thr Asp Val Asp Arg Thr 

            100                 105                 110         





Leu Met Ser Ala Met Thr Asn Leu Ala Ala Leu Phe Pro Pro Glu Gly 

        115                 120                 125             





Val Ser Ile Trp Asn Pro Ile Leu Leu Trp Gln Pro Ile Pro Val His 

    130                 135                 140                 





Thr Val Pro Leu Ser Glu Asp Gln Leu Leu Tyr Leu Pro Phe Arg Asn 

145                 150                 155                 160 





Cys Pro Arg Phe Gln Glu Leu Glu Ser Glu Thr Leu Lys Ser Glu Glu 

                165                 170                 175     





Phe Gln Lys Arg Leu His Pro Tyr Lys Asp Phe Ile Ala Thr Leu Gly 

            180                 185                 190         





Lys Leu Ser Gly Leu His Gly Gln Asp Leu Phe Gly Ile Trp Ser Lys 

        195                 200                 205             





Val Tyr Asp Pro Leu Tyr Cys Glu Ser Val His Asn Phe Thr Leu Pro 

    210                 215                 220                 





Ser Trp Ala Thr Glu Asp Thr Met Thr Lys Leu Arg Glu Leu Ser Glu 

225                 230                 235                 240 





Leu Ser Leu Leu Ser Leu Tyr Gly Ile His Lys Gln Lys Glu Lys Ser 

                245                 250                 255     





Arg Leu Gln Gly Gly Val Leu Val Asn Glu Ile Leu Asn His Met Lys 

            260                 265                 270         





Arg Ala Thr Gln Ile Pro Ser Tyr Lys Lys Leu Ile Met Tyr Ser Ala 

        275                 280                 285             





His Asp Thr Thr Val Ser Gly Leu Gln Met Ala Leu Asp Val Tyr Asn 

    290                 295                 300                 





Gly Leu Leu Pro Pro Tyr Ala Ser Cys His Leu Thr Glu Leu Tyr Phe 

305                 310                 315                 320 





Glu Lys Gly Glu Tyr Phe Val Glu Met Tyr Tyr Arg Asn Glu Thr Gln 

                325                 330                 335     





His Glu Pro Tyr Pro Leu Met Leu Pro Gly Cys Ser Pro Ser Cys Pro 

            340                 345                 350         





Leu Glu Arg Phe Ala Glu Leu Val Gly Pro Val Ile Pro Gln Asp Trp 

        355                 360                 365             





Ser Thr Glu Cys Met Thr Thr Asn Ser His Gln Gly Thr Glu Asp Ser 

    370                 375                 380                 





Thr Asp 

385     





<210>  100

<211>  353

<212>  PRT

<213>  Homo sapiens



<400>  100



Met Arg Ala Ala Pro Leu Leu Leu Ala Arg Ala Ala Ser Leu Ser Leu 

1               5                   10                  15      





Gly Phe Leu Phe Leu Leu Phe Phe Trp Leu Asp Arg Ser Val Leu Ala 

            20                  25                  30          





Lys Glu Leu Lys Phe Val Thr Leu Val Phe Arg His Gly Asp Arg Ser 

        35                  40                  45              





Pro Ile Asp Thr Phe Pro Thr Asp Pro Ile Lys Glu Ser Ser Trp Pro 

    50                  55                  60                  





Gln Gly Phe Gly Gln Leu Thr Gln Leu Gly Met Glu Gln His Tyr Glu 

65                  70                  75                  80  





Leu Gly Glu Tyr Ile Arg Lys Arg Tyr Arg Lys Phe Leu Asn Glu Ser 

                85                  90                  95      





Tyr Lys His Glu Gln Val Tyr Ile Arg Ser Thr Asp Val Asp Arg Thr 

            100                 105                 110         





Leu Met Ser Ala Met Thr Asn Leu Ala Ala Leu Phe Pro Pro Glu Gly 

        115                 120                 125             





Val Ser Ile Trp Asn Pro Ile Leu Leu Trp Gln Pro Ile Pro Val His 

    130                 135                 140                 





Thr Val Pro Leu Ser Glu Asp Gln Asp Phe Ile Ala Thr Leu Gly Lys 

145                 150                 155                 160 





Leu Ser Gly Leu His Gly Gln Asp Leu Phe Gly Ile Trp Ser Lys Val 

                165                 170                 175     





Tyr Asp Pro Leu Tyr Cys Glu Ser Val His Asn Phe Thr Leu Pro Ser 

            180                 185                 190         





Trp Ala Thr Glu Asp Thr Met Thr Lys Leu Arg Glu Leu Ser Glu Leu 

        195                 200                 205             





Ser Leu Leu Ser Leu Tyr Gly Ile His Lys Gln Lys Glu Lys Ser Arg 

    210                 215                 220                 





Leu Gln Gly Gly Val Leu Val Asn Glu Ile Leu Asn His Met Lys Arg 

225                 230                 235                 240 





Ala Thr Gln Ile Pro Ser Tyr Lys Lys Leu Ile Met Tyr Ser Ala His 

                245                 250                 255     





Asp Thr Thr Val Ser Gly Leu Gln Met Ala Leu Asp Val Tyr Asn Gly 

            260                 265                 270         





Leu Leu Pro Pro Tyr Ala Ser Cys His Leu Thr Glu Leu Tyr Phe Glu 

        275                 280                 285             





Lys Gly Glu Tyr Phe Val Glu Met Tyr Tyr Arg Asn Glu Thr Gln His 

    290                 295                 300                 





Glu Pro Tyr Pro Leu Met Leu Pro Gly Cys Ser Pro Ser Cys Pro Leu 

305                 310                 315                 320 





Glu Arg Phe Ala Glu Leu Val Gly Pro Val Ile Pro Gln Asp Trp Ser 

                325                 330                 335     





Thr Glu Cys Met Thr Thr Asn Ser His Gln Gly Thr Glu Asp Ser Thr 

            340                 345                 350         





Asp 

    





<210>  101

<211>  418

<212>  PRT

<213>  Homo sapiens



<400>  101



Met Arg Ala Ala Pro Leu Leu Leu Ala Arg Ala Ala Ser Leu Ser Leu 

1               5                   10                  15      





Gly Phe Leu Phe Leu Leu Phe Phe Trp Leu Asp Arg Ser Val Leu Ala 

            20                  25                  30          





Lys Glu Leu Lys Phe Val Thr Leu Val Phe Arg His Gly Asp Arg Ser 

        35                  40                  45              





Pro Ile Asp Thr Phe Pro Thr Asp Pro Ile Lys Glu Ser Ser Trp Pro 

    50                  55                  60                  





Gln Gly Phe Gly Gln Leu Thr Gln Leu Gly Met Glu Gln His Tyr Glu 

65                  70                  75                  80  





Leu Gly Glu Tyr Ile Arg Lys Arg Tyr Arg Lys Phe Leu Asn Glu Ser 

                85                  90                  95      





Tyr Lys His Glu Gln Val Tyr Ile Arg Ser Thr Asp Val Asp Arg Thr 

            100                 105                 110         





Leu Met Ser Ala Met Thr Asn Leu Ala Ala Leu Phe Pro Pro Glu Gly 

        115                 120                 125             





Val Ser Ile Trp Asn Pro Ile Leu Leu Trp Gln Pro Ile Pro Val His 

    130                 135                 140                 





Thr Val Pro Leu Ser Glu Asp Gln Leu Leu Tyr Leu Pro Phe Arg Asn 

145                 150                 155                 160 





Cys Pro Arg Phe Gln Glu Leu Glu Ser Glu Thr Leu Lys Ser Glu Glu 

                165                 170                 175     





Phe Gln Lys Arg Leu His Pro Tyr Lys Asp Phe Ile Ala Thr Leu Gly 

            180                 185                 190         





Lys Leu Ser Gly Leu His Gly Gln Asp Leu Phe Gly Ile Trp Ser Lys 

        195                 200                 205             





Val Tyr Asp Pro Leu Tyr Cys Glu Ser Val His Asn Phe Thr Leu Pro 

    210                 215                 220                 





Ser Trp Ala Thr Glu Asp Thr Met Thr Lys Leu Arg Glu Leu Ser Glu 

225                 230                 235                 240 





Leu Ser Leu Leu Ser Leu Tyr Gly Ile His Lys Gln Lys Glu Lys Ser 

                245                 250                 255     





Arg Leu Gln Gly Gly Val Leu Val Asn Glu Ile Leu Asn His Met Lys 

            260                 265                 270         





Arg Ala Thr Gln Ile Pro Ser Tyr Lys Lys Leu Ile Met Tyr Ser Ala 

        275                 280                 285             





His Asp Thr Thr Val Ser Gly Leu Gln Met Ala Leu Asp Val Tyr Asn 

    290                 295                 300                 





Gly Leu Leu Pro Pro Tyr Ala Ser Cys His Leu Thr Glu Leu Tyr Phe 

305                 310                 315                 320 





Glu Lys Gly Glu Tyr Phe Val Glu Met Tyr Tyr Arg Asn Glu Thr Gln 

                325                 330                 335     





His Glu Pro Tyr Pro Leu Met Leu Pro Gly Cys Ser Pro Ser Cys Pro 

            340                 345                 350         





Leu Glu Arg Phe Ala Glu Leu Val Gly Pro Val Ile Pro Gln Asp Trp 

        355                 360                 365             





Ser Thr Glu Cys Met Thr Thr Asn Ser His Gln Val Leu Lys Val Ile 

    370                 375                 380                 





Phe Ala Val Ala Phe Cys Leu Ile Ser Ala Val Leu Met Val Leu Leu 

385                 390                 395                 400 





Phe Ile His Ile Arg Arg Gly Leu Cys Trp Gln Arg Glu Ser Tyr Gly 

                405                 410                 415     





Asn Ile 

        





<210>  102

<211>  335

<212>  PRT

<213>  Homo sapiens



<400>  102



Met Pro Arg Pro Arg Leu Leu Ala Ala Leu Cys Gly Ala Leu Leu Cys 

1               5                   10                  15      





Ala Pro Ser Leu Leu Val Ala Leu Asp Ile Cys Ser Lys Asn Pro Cys 

            20                  25                  30          





His Asn Gly Gly Leu Cys Glu Glu Ile Ser Gln Glu Val Arg Gly Asp 

        35                  40                  45              





Val Phe Pro Ser Tyr Thr Cys Thr Cys Leu Lys Gly Tyr Ala Gly Asn 

    50                  55                  60                  





His Cys Glu Thr Lys Cys Val Glu Pro Leu Gly Leu Glu Asn Gly Asn 

65                  70                  75                  80  





Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu 

                85                  90                  95      





Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly 

            100                 105                 110         





Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile 

        115                 120                 125             





Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr Gly Val Val Thr Gln 

    130                 135                 140                 





Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val 

145                 150                 155                 160 





Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe Ile His Asp Val Asn 

                165                 170                 175     





Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn Lys Asn Ala Val His 

            180                 185                 190         





Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr 

        195                 200                 205             





Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly 

    210                 215                 220                 





Cys Glu Leu Asn Gly Cys Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser 

225                 230                 235                 240 





Ile Pro Asp Lys Gln Ile Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly 

                245                 250                 255     





Leu His Leu Phe Ser Trp Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln 

            260                 265                 270         





Gly Asn Phe Asn Ala Trp Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp 

        275                 280                 285             





Leu Gln Ile Phe Pro Gly Asn Trp Asp Asn His Ser His Lys Lys Asn 

    290                 295                 300                 





Leu Phe Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg Ile Leu Pro Val 

305                 310                 315                 320 





Ala Trp His Asn Arg Ile Ala Leu Arg Leu Glu Leu Leu Gly Cys 

                325                 330                 335 





<210>  103

<211>  387

<212>  PRT

<213>  Homo sapiens



<400>  103



Met Pro Arg Pro Arg Leu Leu Ala Ala Leu Cys Gly Ala Leu Leu Cys 

1               5                   10                  15      





Ala Pro Ser Leu Leu Val Ala Leu Asp Ile Cys Ser Lys Asn Pro Cys 

            20                  25                  30          





His Asn Gly Gly Leu Cys Glu Glu Ile Ser Gln Glu Val Arg Gly Asp 

        35                  40                  45              





Val Phe Pro Ser Tyr Thr Cys Thr Cys Leu Lys Gly Tyr Ala Gly Asn 

    50                  55                  60                  





His Cys Glu Thr Lys Cys Val Glu Pro Leu Gly Leu Glu Asn Gly Asn 

65                  70                  75                  80  





Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu 

                85                  90                  95      





Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly 

            100                 105                 110         





Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile 

        115                 120                 125             





Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr Gly Val Val Thr Gln 

    130                 135                 140                 





Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val 

145                 150                 155                 160 





Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe Ile His Asp Val Asn 

                165                 170                 175     





Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn Lys Asn Ala Val His 

            180                 185                 190         





Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr 

        195                 200                 205             





Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly 

    210                 215                 220                 





Cys Glu Leu Asn Gly Cys Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser 

225                 230                 235                 240 





Ile Pro Asp Lys Gln Ile Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly 

                245                 250                 255     





Leu His Leu Phe Ser Trp Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln 

            260                 265                 270         





Gly Asn Phe Asn Ala Trp Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp 

        275                 280                 285             





Leu Gln Val Asp Leu Gly Ser Ser Lys Glu Val Thr Gly Ile Ile Thr 

    290                 295                 300                 





Gln Gly Ala Arg Asn Phe Gly Ser Val Gln Phe Val Ala Ser Tyr Lys 

305                 310                 315                 320 





Val Ala Tyr Ser Asn Asp Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro 

                325                 330                 335     





Arg Thr Gly Ser Ser Lys Ile Phe Pro Gly Asn Trp Asp Asn His Ser 

            340                 345                 350         





His Lys Lys Asn Leu Phe Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg 

        355                 360                 365             





Ile Leu Pro Val Ala Trp His Asn Arg Ile Ala Leu Arg Leu Glu Leu 

    370                 375                 380                 





Leu Gly Cys 

385         





<210>  104

<211>  264

<212>  PRT

<213>  Homo sapiens



<400>  104



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 

            20                  25                  30          





Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 

        35                  40                  45              





Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn 

    50                  55                  60                  





Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg 

65                  70                  75                  80  





Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu 

                85                  90                  95      





Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu 

            100                 105                 110         





Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr 

        115                 120                 125             





Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr 

    130                 135                 140                 





Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln 

145                 150                 155                 160 





Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val 

                165                 170                 175     





Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val 

            180                 185                 190         





Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala 

        195                 200                 205             





Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His 

    210                 215                 220                 





Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys 

225                 230                 235                 240 





Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala 

                245                 250                 255     





Val Ala Ala Thr Ser Ala Asn Leu 

            260                 





<210>  105

<211>  203

<212>  PRT

<213>  Homo sapiens



<400>  105



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 

            20                  25                  30          





Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 

        35                  40                  45              





Thr Glu Lys Asn Ala Ile Pro Ala Pro Thr Thr Thr Lys Ser Cys Arg 

    50                  55                  60                  





Glu Thr Phe Leu Lys Cys Phe Cys Arg Phe Ile Asn Lys Gly Val Phe 

65                  70                  75                  80  





Trp Ala Ser Pro Ile Leu Ser Ser Val Ser Asp Val Pro Phe Pro Phe 

                85                  90                  95      





Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu 

            100                 105                 110         





Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala 

        115                 120                 125             





Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile 

    130                 135                 140                 





Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr 

145                 150                 155                 160 





His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro 

                165                 170                 175     





Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr 

            180                 185                 190         





Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 

        195                 200             





<210>  106

<211>  159

<212>  PRT

<213>  Homo sapiens



<400>  106



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 

            20                  25                  30          





Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 

        35                  40                  45              





Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn 

    50                  55                  60                  





Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg 

65                  70                  75                  80  





Asp Ile Ser Glu Met Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly 

                85                  90                  95      





Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu 

            100                 105                 110         





Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr 

        115                 120                 125             





Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser 

    130                 135                 140                 





Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 

145                 150                 155                 





<210>  107

<211>  475

<212>  PRT

<213>  Homo sapiens



<400>  107



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 

            20                  25                  30          





Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 

        35                  40                  45              





Thr Glu Lys Asn Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His 

    50                  55                  60                  





Ser Pro Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu 

65                  70                  75                  80  





Ala Pro Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln 

                85                  90                  95      





Asp Val Thr Ser Val Pro Val Thr Arg Pro Ala Leu Gly Ser Thr Thr 

            100                 105                 110         





Pro Pro Ala His Asp Val Thr Ser Ala Pro Asp Asn Lys Pro Ala Pro 

        115                 120                 125             





Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 

    130                 135                 140                 





Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 

145                 150                 155                 160 





Ala Pro Asp Asn Arg Pro Ala Leu Gly Ser Thr Ala Pro Pro Val His 

                165                 170                 175     





Asn Val Thr Ser Ala Ser Gly Ser Ala Ser Gly Ser Ala Ser Thr Leu 

            180                 185                 190         





Val His Asn Gly Thr Ser Ala Arg Ala Thr Thr Thr Pro Ala Ser Lys 

        195                 200                 205             





Ser Thr Pro Phe Ser Ile Pro Ser His His Ser Asp Thr Pro Thr Thr 

    210                 215                 220                 





Leu Ala Ser His Ser Thr Lys Thr Asp Ala Ser Ser Thr His His Ser 

225                 230                 235                 240 





Thr Val Pro Pro Leu Thr Ser Ser Asn His Ser Thr Ser Pro Gln Leu 

                245                 250                 255     





Ser Thr Gly Val Ser Phe Phe Phe Leu Ser Phe His Ile Ser Asn Leu 

            260                 265                 270         





Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu 

        275                 280                 285             





Leu Gln Arg Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly 

    290                 295                 300                 





Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val 

305                 310                 315                 320 





Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp 

                325                 330                 335     





Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr 

            340                 345                 350         





Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe 

        355                 360                 365             





Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu 

    370                 375                 380                 





Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala 

385                 390                 395                 400 





Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile 

                405                 410                 415     





Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr 

            420                 425                 430         





His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro 

        435                 440                 445             





Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr 

    450                 455                 460                 





Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 

465                 470                 475 





<210>  108

<211>  282

<212>  PRT

<213>  Homo sapiens



<400>  108



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 

            20                  25                  30          





Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 

        35                  40                  45              





Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Leu Ser 

    50                  55                  60                  





Thr Gly Val Ser Phe Phe Phe Leu Ser Phe His Ile Ser Asn Leu Gln 

65                  70                  75                  80  





Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu 

                85                  90                  95      





Gln Arg Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly 

            100                 105                 110         





Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val 

        115                 120                 125             





Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val 

    130                 135                 140                 





Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn 

145                 150                 155                 160 





Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser 

                165                 170                 175     





Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val 

            180                 185                 190         





Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu 

        195                 200                 205             





Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe 

    210                 215                 220                 





Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His 

225                 230                 235                 240 





Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr 

                245                 250                 255     





Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn 

            260                 265                 270         





Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 

        275                 280         





<210>  109

<211>  238

<212>  PRT

<213>  Homo sapiens



<400>  109



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 

            20                  25                  30          





Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 

        35                  40                  45              





Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Ile Tyr 

    50                  55                  60                  





Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly 

65                  70                  75                  80  





Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn 

                85                  90                  95      





Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala 

            100                 105                 110         





Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro 

        115                 120                 125             





Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile 

    130                 135                 140                 





Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr 

145                 150                 155                 160 





Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln 

                165                 170                 175     





Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr 

            180                 185                 190         





Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp 

        195                 200                 205             





Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu 

    210                 215                 220                 





Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 

225                 230                 235             





<210>  110

<211>  241

<212>  PRT

<213>  Homo sapiens



<400>  110



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 

            20                  25                  30          





Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 

        35                  40                  45              





Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Leu 

    50                  55                  60                  





Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe 

65                  70                  75                  80  





Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly 

                85                  90                  95      





Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 

            100                 105                 110         





Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser 

        115                 120                 125             





Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly 

    130                 135                 140                 





Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala 

145                 150                 155                 160 





Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn 

                165                 170                 175     





Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met 

            180                 185                 190         





Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser 

        195                 200                 205             





Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly 

    210                 215                 220                 





Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn 

225                 230                 235                 240 





Leu 

    





<210>  111

<211>  198

<212>  PRT

<213>  Homo sapiens



<400>  111



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 

            20                  25                  30          





Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 

        35                  40                  45              





Thr Glu Lys Asn Ala Leu Ser Thr Gly Val Ser Phe Phe Phe Leu Ser 

    50                  55                  60                  





Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser 

65                  70                  75                  80  





Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu 

                85                  90                  95      





Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe 

            100                 105                 110         





Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly 

        115                 120                 125             





Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 

    130                 135                 140                 





Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Gly Cys 

145                 150                 155                 160 





Leu Ser Val Pro Pro Lys Glu Leu Arg Ala Ala Gly His Leu Ser Ser 

                165                 170                 175     





Pro Gly Tyr Leu Pro Ser Tyr Glu Arg Val Pro His Leu Pro His Pro 

            180                 185                 190         





Trp Ala Leu Cys Ala Pro 

        195             





<210>  112

<211>  189

<212>  PRT

<213>  Homo sapiens



<400>  112



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 

            20                  25                  30          





Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 

        35                  40                  45              





Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn 

    50                  55                  60                  





Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg 

65                  70                  75                  80  





Asp Ile Ser Glu Met Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala 

                85                  90                  95      





Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu 

            100                 105                 110         





Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu 

        115                 120                 125             





Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro 

    130                 135                 140                 





Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg 

145                 150                 155                 160 





Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser 

                165                 170                 175     





Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 

            180                 185                 





<210>  113

<211>  177

<212>  PRT

<213>  Homo sapiens



<400>  113



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 

            20                  25                  30          





Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 

        35                  40                  45              





Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Leu Ser 

    50                  55                  60                  





Thr Gly Val Ser Phe Phe Phe Leu Ser Phe His Ile Ser Asn Leu Gln 

65                  70                  75                  80  





Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu 

                85                  90                  95      





Gln Arg Asp Ile Ser Glu Met Ala Val Cys Gln Cys Arg Arg Lys Asn 

            100                 105                 110         





Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met 

        115                 120                 125             





Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser 

    130                 135                 140                 





Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly 

145                 150                 155                 160 





Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn 

                165                 170                 175     





Leu 

    





<210>  114

<211>  255

<212>  PRT

<213>  Homo sapiens



<400>  114



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 

            20                  25                  30          





Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 

        35                  40                  45              





Thr Glu Lys Asn Ala Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp 

    50                  55                  60                  





Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu Gln Ile 

65                  70                  75                  80  





Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro 

                85                  90                  95      





Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile 

            100                 105                 110         





Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala 

        115                 120                 125             





Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val 

    130                 135                 140                 





Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly 

145                 150                 155                 160 





Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val 

                165                 170                 175     





Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly 

            180                 185                 190         





Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu 

        195                 200                 205             





Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr 

    210                 215                 220                 





Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser 

225                 230                 235                 240 





Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 

                245                 250                 255 





<210>  115

<211>  150

<212>  PRT

<213>  Homo sapiens



<400>  115



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 

            20                  25                  30          





Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 

        35                  40                  45              





Thr Glu Lys Asn Ala Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp 

    50                  55                  60                  





Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Ala Val Cys Gln 

65                  70                  75                  80  





Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp 

                85                  90                  95      





Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg 

            100                 105                 110         





Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser 

        115                 120                 125             





Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala 

    130                 135                 140                 





Ala Thr Ser Ala Asn Leu 

145                 150 





<210>  116

<211>  158

<212>  PRT

<213>  Homo sapiens



<400>  116



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 

            20                  25                  30          





Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 

        35                  40                  45              





Thr Glu Lys Asn Ala Ile Pro Ala Pro Thr Thr Thr Lys Ser Cys Arg 

    50                  55                  60                  





Glu Thr Phe Leu Lys Cys Phe Cys Arg Phe Ile Asn Lys Gly Val Phe 

65                  70                  75                  80  





Trp Ala Ser Pro Ile Leu Ser Ser Val Trp Gly Trp Gly Ala Arg Leu 

                85                  90                  95      





Gly His Arg Ala Ala Gly Ala Gly Leu Cys Ser Gly Cys Ala Gly His 

            100                 105                 110         





Cys Leu Ser His Cys Leu Gly Cys Leu Ser Val Pro Pro Lys Glu Leu 

        115                 120                 125             





Arg Ala Ala Gly His Leu Ser Ser Pro Gly Tyr Leu Pro Ser Tyr Glu 

    130                 135                 140                 





Arg Val Pro His Leu Pro His Pro Trp Ala Leu Cys Ala Pro 

145                 150                 155             





<210>  117

<211>  484

<212>  PRT

<213>  Homo sapiens



<400>  117



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 

            20                  25                  30          





Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 

        35                  40                  45              





Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Val Ser 

    50                  55                  60                  





Met Thr Ser Ser Val Leu Ser Ser His Ser Pro Gly Ser Gly Ser Ser 

65                  70                  75                  80  





Thr Thr Gln Gly Gln Asp Val Thr Leu Ala Pro Ala Thr Glu Pro Ala 

                85                  90                  95      





Ser Gly Ser Ala Ala Thr Trp Gly Gln Asp Val Thr Ser Val Pro Val 

            100                 105                 110         





Thr Arg Pro Ala Leu Gly Ser Thr Thr Pro Pro Ala His Asp Val Thr 

        115                 120                 125             





Ser Ala Pro Asp Asn Lys Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 

    130                 135                 140                 





His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 

145                 150                 155                 160 





Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Asn Arg Pro Ala 

                165                 170                 175     





Leu Gly Ser Thr Ala Pro Pro Val His Asn Val Thr Ser Ala Ser Gly 

            180                 185                 190         





Ser Ala Ser Gly Ser Ala Ser Thr Leu Val His Asn Gly Thr Ser Ala 

        195                 200                 205             





Arg Ala Thr Thr Thr Pro Ala Ser Lys Ser Thr Pro Phe Ser Ile Pro 

    210                 215                 220                 





Ser His His Ser Asp Thr Pro Thr Thr Leu Ala Ser His Ser Thr Lys 

225                 230                 235                 240 





Thr Asp Ala Ser Ser Thr His His Ser Thr Val Pro Pro Leu Thr Ser 

                245                 250                 255     





Ser Asn His Ser Thr Ser Pro Gln Leu Ser Thr Gly Val Ser Phe Phe 

            260                 265                 270         





Phe Leu Ser Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu 

        275                 280                 285             





Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu 

    290                 295                 300                 





Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn 

305                 310                 315                 320 





Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe 

                325                 330                 335     





Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln 

            340                 345                 350         





Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val 

        355                 360                 365             





Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly 

    370                 375                 380                 





Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val 

385                 390                 395                 400 





Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg 

                405                 410                 415     





Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr 

            420                 425                 430         





His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val 

        435                 440                 445             





Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly 

    450                 455                 460                 





Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr 

465                 470                 475                 480 





Ser Ala Asn Leu 

                





<210>  118

<211>  219

<212>  PRT

<213>  Homo sapiens



<400>  118



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 

            20                  25                  30          





Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 

        35                  40                  45              





Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn 

    50                  55                  60                  





Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg 

65                  70                  75                  80  





Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu 

                85                  90                  95      





Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu 

            100                 105                 110         





Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr 

        115                 120                 125             





Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr 

    130                 135                 140                 





Ile Ser Asp Val Ser Val Trp Gly Trp Gly Ala Arg Leu Gly His Arg 

145                 150                 155                 160 





Ala Ala Gly Ala Gly Leu Cys Ser Gly Cys Ala Gly His Cys Leu Ser 

                165                 170                 175     





His Cys Leu Gly Cys Leu Ser Val Pro Pro Lys Glu Leu Arg Ala Ala 

            180                 185                 190         





Gly His Leu Ser Ser Pro Gly Tyr Leu Pro Ser Tyr Glu Arg Val Pro 

        195                 200                 205             





His Leu Pro His Pro Trp Ala Leu Cys Ala Pro 

    210                 215                 





<210>  119

<211>  217

<212>  PRT

<213>  Homo sapiens



<400>  119



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Gly Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser 

            20                  25                  30          





Val Pro Ser Ser Thr Glu Lys Asn Ala Ile Tyr Lys Gln Gly Gly Phe 

        35                  40                  45              





Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln 

    50                  55                  60                  





Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu 

65                  70                  75                  80  





Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu 

                85                  90                  95      





Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala 

            100                 105                 110         





Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu 

        115                 120                 125             





Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala 

    130                 135                 140                 





Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro 

145                 150                 155                 160 





Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr 

                165                 170                 175     





His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu 

            180                 185                 190         





Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro 

        195                 200                 205             





Ala Val Ala Ala Thr Ser Ala Asn Leu 

    210                 215         





<210>  120

<211>  239

<212>  PRT

<213>  Homo sapiens



<400>  120



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 

            20                  25                  30          





Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 

        35                  40                  45              





Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Ile Pro 

    50                  55                  60                  





Ala Pro Thr Thr Thr Lys Ser Cys Arg Glu Thr Phe Leu Lys Trp Pro 

65                  70                  75                  80  





Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile 

                85                  90                  95      





Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala 

            100                 105                 110         





Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val 

        115                 120                 125             





Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly 

    130                 135                 140                 





Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val 

145                 150                 155                 160 





Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly 

                165                 170                 175     





Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu 

            180                 185                 190         





Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr 

        195                 200                 205             





Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser 

    210                 215                 220                 





Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 

225                 230                 235                 





<210>  121

<211>  230

<212>  PRT

<213>  Homo sapiens



<400>  121



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 

            20                  25                  30          





Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 

        35                  40                  45              





Thr Glu Lys Asn Ala Ile Pro Ala Pro Thr Thr Thr Lys Ser Cys Arg 

    50                  55                  60                  





Glu Thr Phe Leu Lys Trp Pro Gly Ser Val Val Val Gln Leu Thr Leu 

65                  70                  75                  80  





Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe 

                85                  90                  95      





Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser 

            100                 105                 110         





Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly 

        115                 120                 125             





Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val 

    130                 135                 140                 





Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln 

145                 150                 155                 160 





Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp 

                165                 170                 175     





Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg 

            180                 185                 190         





Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser 

        195                 200                 205             





Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala 

    210                 215                 220                 





Ala Thr Ser Ala Asn Leu 

225                 230 





<210>  122

<211>  212

<212>  PRT

<213>  Homo sapiens



<400>  122



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 

            20                  25                  30          





Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 

        35                  40                  45              





Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Ile Pro 

    50                  55                  60                  





Ala Pro Thr Thr Thr Lys Ser Cys Arg Glu Thr Phe Leu Lys Cys Phe 

65                  70                  75                  80  





Cys Arg Phe Ile Asn Lys Gly Val Phe Trp Ala Ser Pro Ile Leu Ser 

                85                  90                  95      





Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly 

            100                 105                 110         





Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val 

        115                 120                 125             





Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg 

    130                 135                 140                 





Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr 

145                 150                 155                 160 





His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val 

                165                 170                 175     





Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly 

            180                 185                 190         





Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr 

        195                 200                 205             





Ser Ala Asn Leu 

    210         





<210>  123

<211>  273

<212>  PRT

<213>  Homo sapiens



<400>  123



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 

            20                  25                  30          





Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 

        35                  40                  45              





Thr Glu Lys Asn Ala Leu Ser Thr Gly Val Ser Phe Phe Phe Leu Ser 

    50                  55                  60                  





Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser 

65                  70                  75                  80  





Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu 

                85                  90                  95      





Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe 

            100                 105                 110         





Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly 

        115                 120                 125             





Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 

    130                 135                 140                 





Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser 

145                 150                 155                 160 





Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly 

                165                 170                 175     





Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala 

            180                 185                 190         





Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn 

        195                 200                 205             





Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met 

    210                 215                 220                 





Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser 

225                 230                 235                 240 





Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly 

                245                 250                 255     





Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn 

            260                 265                 270         





Leu 

    





<210>  124

<211>  575

<212>  PRT

<213>  Homo sapiens



<400>  124



Met Asp Leu Val Leu Lys Arg Cys Leu Leu His Leu Ala Val Ile Gly 

1               5                   10                  15      





Ala Leu Leu Ala Val Gly Ala Thr Lys Gly Ser Gln Val Trp Gly Gly 

            20                  25                  30          





Gln Pro Val Tyr Pro Gln Glu Thr Asp Asp Ala Cys Ile Phe Pro Asp 

        35                  40                  45              





Gly Gly Pro Cys Pro Ser Gly Ser Trp Ser Gln Lys Arg Ser Phe Val 

    50                  55                  60                  





Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp Gln Val Leu Gly Gly Pro 

65                  70                  75                  80  





Val Ser Gly Leu Ser Ile Gly Thr Gly Arg Ala Met Leu Gly Thr His 

                85                  90                  95      





Thr Met Glu Val Thr Val Tyr His Arg Arg Gly Ser Arg Ser Tyr Val 

            100                 105                 110         





Pro Leu Ala His Ser Ser Ser Ala Phe Thr Ile Thr Asp Gln Val Pro 

        115                 120                 125             





Phe Ser Val Ser Val Ser Gln Leu Arg Ala Leu Asp Gly Gly Asn Lys 

    130                 135                 140                 





His Phe Leu Arg Asn Gln Pro Leu Thr Phe Ala Leu Gln Leu His Asp 

145                 150                 155                 160 





Pro Ser Gly Tyr Leu Ala Glu Ala Asp Leu Ser Tyr Thr Trp Asp Phe 

                165                 170                 175     





Gly Asp Ser Ser Gly Thr Leu Ile Ser Arg Ala Leu Val Val Thr His 

            180                 185                 190         





Thr Tyr Leu Glu Pro Gly Pro Val Thr Ala Gln Val Val Leu Gln Ala 

        195                 200                 205             





Ala Ile Pro Leu Thr Ser Cys Gly Ser Ser Pro Val Pro Gly Thr Thr 

    210                 215                 220                 





Asp Gly His Arg Pro Thr Ala Glu Ala Pro Asn Thr Thr Ala Gly Gln 

225                 230                 235                 240 





Val Pro Thr Thr Glu Val Val Gly Thr Thr Pro Gly Gln Ala Pro Thr 

                245                 250                 255     





Ala Glu Pro Ser Gly Thr Thr Ser Val Gln Val Pro Thr Thr Glu Val 

            260                 265                 270         





Ile Ser Thr Ala Pro Val Gln Met Pro Thr Ala Glu Ser Thr Gly Met 

        275                 280                 285             





Thr Pro Glu Lys Val Pro Val Ser Glu Val Met Gly Thr Thr Leu Ala 

    290                 295                 300                 





Glu Met Ser Thr Pro Glu Ala Thr Gly Met Thr Pro Ala Glu Val Ser 

305                 310                 315                 320 





Ile Val Val Leu Ser Gly Thr Thr Ala Ala Gln Val Thr Thr Thr Glu 

                325                 330                 335     





Trp Val Glu Thr Thr Ala Arg Glu Leu Pro Ile Pro Glu Pro Glu Gly 

            340                 345                 350         





Pro Asp Ala Ser Ser Ile Met Ser Thr Glu Ser Ile Thr Gly Ser Leu 

        355                 360                 365             





Gly Pro Leu Leu Asp Gly Thr Ala Thr Leu Arg Leu Val Lys Arg Gln 

    370                 375                 380                 





Val Pro Leu Asp Cys Val Leu Tyr Arg Tyr Gly Ser Phe Ser Val Thr 

385                 390                 395                 400 





Leu Asp Ile Val Gln Gly Ile Glu Ser Ala Glu Ile Leu Gln Ala Val 

                405                 410                 415     





Pro Ser Gly Glu Gly Asp Ala Phe Glu Leu Thr Val Ser Cys Gln Gly 

            420                 425                 430         





Gly Leu Pro Lys Glu Ala Cys Met Glu Ile Ser Ser Pro Gly Cys Gln 

        435                 440                 445             





Pro Pro Ala Gln Arg Leu Cys Gln Pro Val Leu Pro Ser Pro Ala Cys 

    450                 455                 460                 





Gln Leu Val Leu His Gln Ile Leu Lys Gly Gly Ser Gly Thr Tyr Cys 

465                 470                 475                 480 





Leu Asn Val Ser Leu Ala Asp Thr Asn Ser Leu Ala Val Val Ser Thr 

                485                 490                 495     





Gln Leu Ile Met Pro Gly Gln Glu Ala Gly Leu Gly Gln Val Pro Leu 

            500                 505                 510         





Ile Val Gly Ile Leu Leu Val Leu Met Ala Val Val Leu Ala Ser Leu 

        515                 520                 525             





Ile Tyr Arg Arg Arg Leu Met Lys Gln Asp Phe Ser Val Pro Gln Leu 

    530                 535                 540                 





Pro His Ser Ser Ser His Trp Leu Arg Leu Pro Arg Ile Phe Cys Ser 

545                 550                 555                 560 





Cys Pro Ile Gly Glu Asn Ser Pro Leu Leu Ser Gly Gln Gln Val 

                565                 570                 575 





<210>  125

<211>  668

<212>  PRT

<213>  Homo sapiens



<400>  125



Met Asp Leu Val Leu Lys Arg Cys Leu Leu His Leu Ala Val Ile Gly 

1               5                   10                  15      





Ala Leu Leu Ala Val Gly Ala Thr Lys Val Pro Arg Asn Gln Asp Trp 

            20                  25                  30          





Leu Gly Val Ser Arg Gln Leu Arg Thr Lys Ala Trp Asn Arg Gln Leu 

        35                  40                  45              





Tyr Pro Glu Trp Thr Glu Ala Gln Arg Leu Asp Cys Trp Arg Gly Gly 

    50                  55                  60                  





Gln Val Ser Leu Lys Val Ser Asn Asp Gly Pro Thr Leu Ile Gly Ala 

65                  70                  75                  80  





Asn Ala Ser Phe Ser Ile Ala Leu Asn Phe Pro Gly Ser Gln Lys Val 

                85                  90                  95      





Leu Pro Asp Gly Gln Val Ile Trp Val Asn Asn Thr Ile Ile Asn Gly 

            100                 105                 110         





Ser Gln Val Trp Gly Gly Gln Pro Val Tyr Pro Gln Glu Thr Asp Asp 

        115                 120                 125             





Ala Cys Ile Phe Pro Asp Gly Gly Pro Cys Pro Ser Gly Ser Trp Ser 

    130                 135                 140                 





Gln Lys Arg Ser Phe Val Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp 

145                 150                 155                 160 





Gln Val Leu Gly Gly Pro Val Ser Gly Leu Ser Ile Gly Thr Gly Arg 

                165                 170                 175     





Ala Met Leu Gly Thr His Thr Met Glu Val Thr Val Tyr His Arg Arg 

            180                 185                 190         





Gly Ser Arg Ser Tyr Val Pro Leu Ala His Ser Ser Ser Ala Phe Thr 

        195                 200                 205             





Ile Thr Asp Gln Val Pro Phe Ser Val Ser Val Ser Gln Leu Arg Ala 

    210                 215                 220                 





Leu Asp Gly Gly Asn Lys His Phe Leu Arg Asn Gln Pro Leu Thr Phe 

225                 230                 235                 240 





Ala Leu Gln Leu His Asp Pro Ser Gly Tyr Leu Ala Glu Ala Asp Leu 

                245                 250                 255     





Ser Tyr Thr Trp Asp Phe Gly Asp Ser Ser Gly Thr Leu Ile Ser Arg 

            260                 265                 270         





Ala Leu Val Val Thr His Thr Tyr Leu Glu Pro Gly Pro Val Thr Ala 

        275                 280                 285             





Gln Val Val Leu Gln Ala Ala Ile Pro Leu Thr Ser Cys Gly Ser Ser 

    290                 295                 300                 





Pro Val Pro Gly Thr Thr Asp Gly His Arg Pro Thr Ala Glu Ala Pro 

305                 310                 315                 320 





Asn Thr Thr Ala Gly Gln Val Pro Thr Thr Glu Val Val Gly Thr Thr 

                325                 330                 335     





Pro Gly Gln Ala Pro Thr Ala Glu Pro Ser Gly Thr Thr Ser Val Gln 

            340                 345                 350         





Val Pro Thr Thr Glu Val Ile Ser Thr Ala Pro Val Gln Met Pro Thr 

        355                 360                 365             





Ala Glu Ser Thr Gly Met Thr Pro Glu Lys Val Pro Val Ser Glu Val 

    370                 375                 380                 





Met Gly Thr Thr Leu Ala Glu Met Ser Thr Pro Glu Ala Thr Gly Met 

385                 390                 395                 400 





Thr Pro Ala Glu Val Ser Ile Val Val Leu Ser Gly Thr Thr Ala Ala 

                405                 410                 415     





Gln Val Thr Thr Thr Glu Trp Val Glu Thr Thr Ala Arg Glu Leu Pro 

            420                 425                 430         





Ile Pro Glu Pro Glu Gly Pro Asp Ala Ser Ser Ile Met Ser Thr Glu 

        435                 440                 445             





Ser Ile Thr Gly Ser Leu Gly Pro Leu Leu Asp Gly Thr Ala Thr Leu 

    450                 455                 460                 





Arg Leu Val Lys Arg Gln Val Pro Leu Asp Cys Val Leu Tyr Arg Tyr 

465                 470                 475                 480 





Gly Ser Phe Ser Val Thr Leu Asp Ile Val Gln Gly Ile Glu Ser Ala 

                485                 490                 495     





Glu Ile Leu Gln Ala Val Pro Ser Gly Glu Gly Asp Ala Phe Glu Leu 

            500                 505                 510         





Thr Val Ser Cys Gln Gly Gly Leu Pro Lys Glu Ala Cys Met Glu Ile 

        515                 520                 525             





Ser Ser Pro Gly Cys Gln Pro Pro Ala Gln Arg Leu Cys Gln Pro Val 

    530                 535                 540                 





Leu Pro Ser Pro Ala Cys Gln Leu Val Leu His Gln Ile Leu Lys Gly 

545                 550                 555                 560 





Gly Ser Gly Thr Tyr Cys Leu Asn Val Ser Leu Ala Asp Thr Asn Ser 

                565                 570                 575     





Leu Ala Val Val Ser Thr Gln Leu Ile Met Pro Val Pro Gly Ile Leu 

            580                 585                 590         





Leu Thr Gly Gln Glu Ala Gly Leu Gly Gln Val Pro Leu Ile Val Gly 

        595                 600                 605             





Ile Leu Leu Val Leu Met Ala Val Val Leu Ala Ser Leu Ile Tyr Arg 

    610                 615                 620                 





Arg Arg Leu Met Lys Gln Asp Phe Ser Val Pro Gln Leu Pro His Ser 

625                 630                 635                 640 





Ser Ser His Trp Leu Arg Leu Pro Arg Ile Phe Cys Ser Cys Pro Ile 

                645                 650                 655     





Gly Glu Asn Ser Pro Leu Leu Ser Gly Gln Gln Val 

            660                 665             





<210>  126

<211>  661

<212>  PRT

<213>  Homo sapiens



<400>  126



Met Asp Leu Val Leu Lys Arg Cys Leu Leu His Leu Ala Val Ile Gly 

1               5                   10                  15      





Ala Leu Leu Ala Val Gly Ala Thr Lys Val Pro Arg Asn Gln Asp Trp 

            20                  25                  30          





Leu Gly Val Ser Arg Gln Leu Arg Thr Lys Ala Trp Asn Arg Gln Leu 

        35                  40                  45              





Tyr Pro Glu Trp Thr Glu Ala Gln Arg Leu Asp Cys Trp Arg Gly Gly 

    50                  55                  60                  





Gln Val Ser Leu Lys Val Ser Asn Asp Gly Pro Thr Leu Ile Gly Ala 

65                  70                  75                  80  





Asn Ala Ser Phe Ser Ile Ala Leu Asn Phe Pro Gly Ser Gln Lys Val 

                85                  90                  95      





Leu Pro Asp Gly Gln Val Ile Trp Val Asn Asn Thr Ile Ile Asn Gly 

            100                 105                 110         





Ser Gln Val Trp Gly Gly Gln Pro Val Tyr Pro Gln Glu Thr Asp Asp 

        115                 120                 125             





Ala Cys Ile Phe Pro Asp Gly Gly Pro Cys Pro Ser Gly Ser Trp Ser 

    130                 135                 140                 





Gln Lys Arg Ser Phe Val Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp 

145                 150                 155                 160 





Gln Val Leu Gly Gly Pro Val Ser Gly Leu Ser Ile Gly Thr Gly Arg 

                165                 170                 175     





Ala Met Leu Gly Thr His Thr Met Glu Val Thr Val Tyr His Arg Arg 

            180                 185                 190         





Gly Ser Arg Ser Tyr Val Pro Leu Ala His Ser Ser Ser Ala Phe Thr 

        195                 200                 205             





Ile Thr Asp Gln Val Pro Phe Ser Val Ser Val Ser Gln Leu Arg Ala 

    210                 215                 220                 





Leu Asp Gly Gly Asn Lys His Phe Leu Arg Asn Gln Pro Leu Thr Phe 

225                 230                 235                 240 





Ala Leu Gln Leu His Asp Pro Ser Gly Tyr Leu Ala Glu Ala Asp Leu 

                245                 250                 255     





Ser Tyr Thr Trp Asp Phe Gly Asp Ser Ser Gly Thr Leu Ile Ser Arg 

            260                 265                 270         





Ala Leu Val Val Thr His Thr Tyr Leu Glu Pro Gly Pro Val Thr Ala 

        275                 280                 285             





Gln Val Val Leu Gln Ala Ala Ile Pro Leu Thr Ser Cys Gly Ser Ser 

    290                 295                 300                 





Pro Val Pro Gly Thr Thr Asp Gly His Arg Pro Thr Ala Glu Ala Pro 

305                 310                 315                 320 





Asn Thr Thr Ala Gly Gln Val Pro Thr Thr Glu Val Val Gly Thr Thr 

                325                 330                 335     





Pro Gly Gln Ala Pro Thr Ala Glu Pro Ser Gly Thr Thr Ser Val Gln 

            340                 345                 350         





Val Pro Thr Thr Glu Val Ile Ser Thr Ala Pro Val Gln Met Pro Thr 

        355                 360                 365             





Ala Glu Ser Thr Gly Met Thr Pro Glu Lys Val Pro Val Ser Glu Val 

    370                 375                 380                 





Met Gly Thr Thr Leu Ala Glu Met Ser Thr Pro Glu Ala Thr Gly Met 

385                 390                 395                 400 





Thr Pro Ala Glu Val Ser Ile Val Val Leu Ser Gly Thr Thr Ala Ala 

                405                 410                 415     





Gln Val Thr Thr Thr Glu Trp Val Glu Thr Thr Ala Arg Glu Leu Pro 

            420                 425                 430         





Ile Pro Glu Pro Glu Gly Pro Asp Ala Ser Ser Ile Met Ser Thr Glu 

        435                 440                 445             





Ser Ile Thr Gly Ser Leu Gly Pro Leu Leu Asp Gly Thr Ala Thr Leu 

    450                 455                 460                 





Arg Leu Val Lys Arg Gln Val Pro Leu Asp Cys Val Leu Tyr Arg Tyr 

465                 470                 475                 480 





Gly Ser Phe Ser Val Thr Leu Asp Ile Val Gln Gly Ile Glu Ser Ala 

                485                 490                 495     





Glu Ile Leu Gln Ala Val Pro Ser Gly Glu Gly Asp Ala Phe Glu Leu 

            500                 505                 510         





Thr Val Ser Cys Gln Gly Gly Leu Pro Lys Glu Ala Cys Met Glu Ile 

        515                 520                 525             





Ser Ser Pro Gly Cys Gln Pro Pro Ala Gln Arg Leu Cys Gln Pro Val 

    530                 535                 540                 





Leu Pro Ser Pro Ala Cys Gln Leu Val Leu His Gln Ile Leu Lys Gly 

545                 550                 555                 560 





Gly Ser Gly Thr Tyr Cys Leu Asn Val Ser Leu Ala Asp Thr Asn Ser 

                565                 570                 575     





Leu Ala Val Val Ser Thr Gln Leu Ile Met Pro Gly Gln Glu Ala Gly 

            580                 585                 590         





Leu Gly Gln Val Pro Leu Ile Val Gly Ile Leu Leu Val Leu Met Ala 

        595                 600                 605             





Val Val Leu Ala Ser Leu Ile Tyr Arg Arg Arg Leu Met Lys Gln Asp 

    610                 615                 620                 





Phe Ser Val Pro Gln Leu Pro His Ser Ser Ser His Trp Leu Arg Leu 

625                 630                 635                 640 





Pro Arg Ile Phe Cys Ser Cys Pro Ile Gly Glu Asn Ser Pro Leu Leu 

                645                 650                 655     





Ser Gly Gln Gln Val 

            660     





<210>  127

<211>  118

<212>  PRT

<213>  Homo sapiens



<400>  127



Met Pro Arg Glu Asp Ala His Phe Ile Tyr Gly Tyr Pro Lys Lys Gly 

1               5                   10                  15      





His Gly His Ser Tyr Thr Thr Ala Glu Glu Ala Ala Gly Ile Gly Ile 

            20                  25                  30          





Leu Thr Val Ile Leu Gly Val Leu Leu Leu Ile Gly Cys Trp Tyr Cys 

        35                  40                  45              





Arg Arg Arg Asn Gly Tyr Arg Ala Leu Met Asp Lys Ser Leu His Val 

    50                  55                  60                  





Gly Thr Gln Cys Ala Leu Thr Arg Arg Cys Pro Gln Glu Gly Phe Asp 

65                  70                  75                  80  





His Arg Asp Ser Lys Val Ser Leu Gln Glu Lys Asn Cys Glu Pro Val 

                85                  90                  95      





Val Pro Asn Ala Pro Pro Ala Tyr Glu Lys Leu Ser Ala Glu Gln Ser 

            100                 105                 110         





Pro Pro Pro Tyr Ser Pro 

        115             





<210>  128

<211>  1069

<212>  PRT

<213>  Homo sapiens



<400>  128



Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser 

1               5                   10                  15      





His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly 

            20                  25                  30          





Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg 

        35                  40                  45              





Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro 

    50                  55                  60                  





Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu 

65                  70                  75                  80  





Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val 

                85                  90                  95      





Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro 

            100                 105                 110         





Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr 

        115                 120                 125             





Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val 

    130                 135                 140                 





Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val 

145                 150                 155                 160 





Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr 

                165                 170                 175     





Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly 

            180                 185                 190         





Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg 

        195                 200                 205             





Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg 

    210                 215                 220                 





Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg 

225                 230                 235                 240 





Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp 

                245                 250                 255     





Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val 

            260                 265                 270         





Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala 

        275                 280                 285             





Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His 

    290                 295                 300                 





Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro 

305                 310                 315                 320 





Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly 

                325                 330                 335     





Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro 

            340                 345                 350         





Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser 

        355                 360                 365             





Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln 

    370                 375                 380                 





Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His 

385                 390                 395                 400 





Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg 

                405                 410                 415     





Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln 

            420                 425                 430         





Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu 

        435                 440                 445             





Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe 

    450                 455                 460                 





Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser 

465                 470                 475                 480 





Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser 

                485                 490                 495     





Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met 

            500                 505                 510         





Ser Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys 

        515                 520                 525             





Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe 

    530                 535                 540                 





Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe 

545                 550                 555                 560 





Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr 

                565                 570                 575     





Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His 

            580                 585                 590         





Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln 

        595                 600                 605             





His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile 

    610                 615                 620                 





Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val 

625                 630                 635                 640 





Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser 

                645                 650                 655     





Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg 

            660                 665                 670         





Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg 

        675                 680                 685             





Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro 

    690                 695                 700                 





Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr Ile 

705                 710                 715                 720 





Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro Gln 

                725                 730                 735     





Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala His 

            740                 745                 750         





Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr Asp 

        755                 760                 765             





Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr Ser 

    770                 775                 780                 





Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn Glu 

785                 790                 795                 800 





Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His His 

                805                 810                 815     





Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile Pro 

            820                 825                 830         





Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly Asp 

        835                 840                 845             





Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu Leu 

    850                 855                 860                 





Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr His Ala 

865                 870                 875                 880 





Lys Thr Phe Leu Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr 

                885                 890                 895     





Phe Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe 

            900                 905                 910         





Gly Val Leu Arg Leu Lys Cys His Ser Leu Phe Leu Asp Leu Gln Val 

        915                 920                 925             





Asn Ser Leu Gln Thr Val Cys Thr Asn Ile Tyr Lys Ile Leu Leu Leu 

    930                 935                 940                 





Gln Ala Tyr Arg Phe His Ala Cys Val Leu Gln Leu Pro Phe His Gln 

945                 950                 955                 960 





Gln Val Trp Lys Asn Pro Thr Phe Phe Leu Arg Val Ile Ser Asp Thr 

                965                 970                 975     





Ala Ser Leu Cys Tyr Ser Ile Leu Lys Ala Lys Asn Ala Gly Met Ser 

            980                 985                 990         





Leu Gly Ala Lys Gly Ala Ala Gly  Pro Leu Pro Ser Glu  Ala Val Gln 

        995                 1000                 1005             





Trp Leu  Cys His Gln Ala Phe  Leu Leu Lys Leu Thr  Arg His Arg 

    1010                 1015                 1020             





Val Thr  Tyr Val Pro Leu Leu  Gly Ser Leu Arg Thr  Ala Gln Thr 

    1025                 1030                 1035             





Gln Leu  Ser Arg Lys Leu Pro  Gly Thr Thr Leu Thr  Ala Leu Glu 

    1040                 1045                 1050             





Ala Ala  Ala Asn Pro Ala Leu  Pro Ser Asp Phe Lys  Thr Ile Leu 

    1055                 1060                 1065             





Asp 

    





<210>  129

<211>  1132

<212>  PRT

<213>  Homo sapiens



<400>  129



Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser 

1               5                   10                  15      





His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly 

            20                  25                  30          





Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg 

        35                  40                  45              





Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro 

    50                  55                  60                  





Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu 

65                  70                  75                  80  





Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val 

                85                  90                  95      





Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro 

            100                 105                 110         





Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr 

        115                 120                 125             





Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val 

    130                 135                 140                 





Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val 

145                 150                 155                 160 





Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr 

                165                 170                 175     





Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly 

            180                 185                 190         





Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg 

        195                 200                 205             





Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg 

    210                 215                 220                 





Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg 

225                 230                 235                 240 





Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp 

                245                 250                 255     





Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val 

            260                 265                 270         





Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala 

        275                 280                 285             





Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His 

    290                 295                 300                 





Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro 

305                 310                 315                 320 





Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly 

                325                 330                 335     





Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro 

            340                 345                 350         





Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser 

        355                 360                 365             





Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln 

    370                 375                 380                 





Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His 

385                 390                 395                 400 





Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg 

                405                 410                 415     





Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln 

            420                 425                 430         





Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu 

        435                 440                 445             





Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe 

    450                 455                 460                 





Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser 

465                 470                 475                 480 





Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser 

                485                 490                 495     





Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met 

            500                 505                 510         





Ser Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys 

        515                 520                 525             





Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe 

    530                 535                 540                 





Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe 

545                 550                 555                 560 





Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr 

                565                 570                 575     





Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His 

            580                 585                 590         





Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln 

        595                 600                 605             





His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile 

    610                 615                 620                 





Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val 

625                 630                 635                 640 





Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser 

                645                 650                 655     





Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg 

            660                 665                 670         





Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg 

        675                 680                 685             





Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro 

    690                 695                 700                 





Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr Ile 

705                 710                 715                 720 





Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro Gln 

                725                 730                 735     





Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala His 

            740                 745                 750         





Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr Asp 

        755                 760                 765             





Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr Ser 

    770                 775                 780                 





Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn Glu 

785                 790                 795                 800 





Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His His 

                805                 810                 815     





Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile Pro 

            820                 825                 830         





Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly Asp 

        835                 840                 845             





Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu Leu 

    850                 855                 860                 





Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr His Ala 

865                 870                 875                 880 





Lys Thr Phe Leu Arg Thr Leu Val Arg Gly Val Pro Glu Tyr Gly Cys 

                885                 890                 895     





Val Val Asn Leu Arg Lys Thr Val Val Asn Phe Pro Val Glu Asp Glu 

            900                 905                 910         





Ala Leu Gly Gly Thr Ala Phe Val Gln Met Pro Ala His Gly Leu Phe 

        915                 920                 925             





Pro Trp Cys Gly Leu Leu Leu Asp Thr Arg Thr Leu Glu Val Gln Ser 

    930                 935                 940                 





Asp Tyr Ser Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr Phe 

945                 950                 955                 960 





Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe Gly 

                965                 970                 975     





Val Leu Arg Leu Lys Cys His Ser Leu Phe Leu Asp Leu Gln Val Asn 

            980                 985                 990         





Ser Leu Gln Thr Val Cys Thr Asn  Ile Tyr Lys Ile Leu  Leu Leu Gln 

        995                 1000                 1005             





Ala Tyr  Arg Phe His Ala Cys  Val Leu Gln Leu Pro  Phe His Gln 

    1010                 1015                 1020             





Gln Val  Trp Lys Asn Pro Thr  Phe Phe Leu Arg Val  Ile Ser Asp 

    1025                 1030                 1035             





Thr Ala  Ser Leu Cys Tyr Ser  Ile Leu Lys Ala Lys  Asn Ala Gly 

    1040                 1045                 1050             





Met Ser  Leu Gly Ala Lys Gly  Ala Ala Gly Pro Leu  Pro Ser Glu 

    1055                 1060                 1065             





Ala Val  Gln Trp Leu Cys His  Gln Ala Phe Leu Leu  Lys Leu Thr 

    1070                 1075                 1080             





Arg His  Arg Val Thr Tyr Val  Pro Leu Leu Gly Ser  Leu Arg Thr 

    1085                 1090                 1095             





Ala Gln  Thr Gln Leu Ser Arg  Lys Leu Pro Gly Thr  Thr Leu Thr 

    1100                 1105                 1110             





Ala Leu  Glu Ala Ala Ala Asn  Pro Ala Leu Pro Ser  Asp Phe Lys 

    1115                 1120                 1125             





Thr Ile  Leu Asp 

    1130         





<210>  130

<211>  353

<212>  PRT

<213>  Human T-lymphotropic virus 1



<400>  130



Met Ala His Phe Pro Gly Phe Gly Gln Ser Leu Leu Phe Gly Tyr Pro 

1               5                   10                  15      





Val Tyr Val Phe Gly Asp Cys Val Gln Gly Asp Trp Cys Pro Ile Ser 

            20                  25                  30          





Gly Gly Leu Cys Ser Ala Arg Leu His Arg His Ala Leu Leu Ala Thr 

        35                  40                  45              





Cys Pro Glu His Gln Ile Thr Trp Asp Pro Ile Asp Gly Arg Val Ile 

    50                  55                  60                  





Gly Ser Ala Leu Gln Phe Leu Ile Pro Arg Leu Pro Ser Phe Pro Thr 

65                  70                  75                  80  





Gln Arg Thr Ser Lys Thr Leu Lys Val Leu Thr Pro Pro Ile Thr His 

                85                  90                  95      





Thr Thr Pro Asn Ile Pro Pro Ser Phe Leu Gln Ala Met Arg Lys Tyr 

            100                 105                 110         





Ser Pro Phe Arg Asn Gly Tyr Met Glu Pro Thr Leu Gly Gln His Leu 

        115                 120                 125             





Pro Thr Leu Ser Phe Pro Asp Pro Gly Leu Arg Pro Gln Asn Leu Tyr 

    130                 135                 140                 





Thr Leu Trp Gly Gly Ser Val Val Cys Met Tyr Leu Tyr Gln Leu Ser 

145                 150                 155                 160 





Pro Pro Ile Thr Trp Pro Leu Leu Pro His Val Ile Phe Cys His Pro 

                165                 170                 175     





Gly Gln Leu Gly Ala Phe Leu Thr Asn Val Pro Tyr Lys Arg Ile Glu 

            180                 185                 190         





Lys Leu Leu Tyr Lys Ile Ser Leu Thr Thr Gly Ala Leu Ile Ile Leu 

        195                 200                 205             





Pro Glu Asp Cys Leu Pro Thr Thr Leu Phe Gln Pro Ala Arg Ala Pro 

    210                 215                 220                 





Val Thr Leu Thr Ala Trp Gln Asn Gly Leu Leu Pro Phe His Ser Thr 

225                 230                 235                 240 





Leu Thr Thr Pro Gly Leu Ile Trp Thr Phe Thr Asp Gly Thr Pro Met 

                245                 250                 255     





Ile Ser Gly Pro Cys Pro Lys Asp Gly Gln Pro Ser Leu Val Leu Gln 

            260                 265                 270         





Ser Ser Ser Phe Ile Phe His Lys Phe Gln Thr Lys Ala Tyr His Pro 

        275                 280                 285             





Ser Phe Leu Leu Ser His Gly Leu Ile Gln Tyr Ser Ser Phe His Asn 

    290                 295                 300                 





Leu His Leu Leu Phe Glu Glu Tyr Thr Asn Ile Pro Ile Ser Leu Leu 

305                 310                 315                 320 





Phe Asn Glu Lys Glu Ala Asp Asp Asn Asp His Glu Pro Gln Ile Ser 

                325                 330                 335     





Pro Gly Gly Leu Glu Pro Leu Ser Glu Lys His Phe Arg Glu Thr Glu 

            340                 345                 350         





Val 

    





<210>  131

<211>  345

<212>  PRT

<213>  Human T-lymphotropic virus 4



<400>  131



Met Ala His Phe Pro Gly Phe Gly Gln Ser Leu Leu Tyr Gly Tyr Pro 

1               5                   10                  15      





Val Tyr Val Phe Gly Asp Cys Val Gln Ala Asp Trp Cys Pro Ile Ser 

            20                  25                  30          





Gly Gly Leu Cys Ser Pro Arg Leu His Arg His Ala Leu Leu Ala Thr 

        35                  40                  45              





Cys Pro Glu His Gln Ile Thr Trp Asp Pro Ile Asp Gly Arg Val Val 

    50                  55                  60                  





Gly Ser Pro Leu Gln Tyr Leu Ile Pro Arg Leu Pro Ser Phe Pro Thr 

65                  70                  75                  80  





Gln Arg Thr Ser Lys Thr Leu Lys Val Leu Thr Pro Pro Thr Thr Pro 

                85                  90                  95      





Val Thr Pro Lys Val Pro Pro Ser Phe Phe Gln Ser Val Arg Arg His 

            100                 105                 110         





Ser Pro Tyr Arg Asn Gly Cys Leu Glu Thr Thr Leu Gly Glu Gln Leu 

        115                 120                 125             





Pro Ser Leu Ala Phe Pro Glu Pro Gly Leu Arg Pro Gln Asn Val Tyr 

    130                 135                 140                 





Thr Ile Trp Gly Lys Thr Ile Val Cys Leu Tyr Ile Tyr Gln Leu Ser 

145                 150                 155                 160 





Pro Pro Met Thr Trp Pro Leu Ile Pro His Val Ile Phe Cys Asn Pro 

                165                 170                 175     





Arg Gln Leu Gly Ala Phe Leu Ser Asn Val Pro Pro Lys Arg Leu Glu 

            180                 185                 190         





Glu Leu Leu Tyr Lys Leu Tyr Leu His Thr Gly Ala Ile Ile Ile Leu 

        195                 200                 205             





Pro Glu Asp Ala Leu Pro Thr Thr Leu Phe Gln Pro Val Arg Ala Pro 

    210                 215                 220                 





Cys Val Gln Thr Thr Trp Asn Thr Gly Leu Leu Pro Tyr Gln Pro Asn 

225                 230                 235                 240 





Leu Thr Thr Pro Gly Leu Ile Trp Thr Phe Asn Asp Gly Ser Pro Met 

                245                 250                 255     





Ile Ser Gly Pro Cys Pro Lys Ala Gly Gln Pro Ser Leu Val Val Gln 

            260                 265                 270         





Ser Ser Leu Leu Ile Phe Glu Arg Phe Gln Thr Lys Ala Tyr His Pro 

        275                 280                 285             





Ser Tyr Leu Leu Ser His Gln Leu Ile Gln Tyr Ser Ser Phe His His 

    290                 295                 300                 





Leu Tyr Leu Leu Phe Asp Glu Tyr Thr Thr Ile Pro Phe Ser Leu Leu 

305                 310                 315                 320 





Phe Lys Glu Lys Glu Gly Asp Asp Arg Asp Asn Asp Pro Leu Pro Gly 

                325                 330                 335     





Ala Thr Ala Ser Pro Gln Gly Gln Asn 

            340                 345 





<210>  132

<211>  180

<212>  PRT

<213>  Homo sapiens



<400>  132



Met Gln Ala Glu Gly Arg Gly Thr Gly Gly Ser Thr Gly Asp Ala Asp 

1               5                   10                  15      





Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala Gly 

            20                  25                  30          





Gly Pro Gly Glu Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala 

        35                  40                  45              





Gly Ala Ala Arg Ala Ser Gly Pro Gly Gly Gly Ala Pro Arg Gly Pro 

    50                  55                  60                  





His Gly Gly Ala Ala Ser Gly Leu Asn Gly Cys Cys Arg Cys Gly Ala 

65                  70                  75                  80  





Arg Gly Pro Glu Ser Arg Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe 

                85                  90                  95      





Ala Thr Pro Met Glu Ala Glu Leu Ala Arg Arg Ser Leu Ala Gln Asp 

            100                 105                 110         





Ala Pro Pro Leu Pro Val Pro Gly Val Leu Leu Lys Glu Phe Thr Val 

        115                 120                 125             





Ser Gly Asn Ile Leu Thr Ile Arg Leu Thr Ala Ala Asp His Arg Gln 

    130                 135                 140                 





Leu Gln Leu Ser Ile Ser Ser Cys Leu Gln Gln Leu Ser Leu Leu Met 

145                 150                 155                 160 





Trp Ile Thr Gln Cys Phe Leu Pro Val Phe Leu Ala Gln Pro Pro Ser 

                165                 170                 175     





Gly Gln Arg Arg 

            180 





<210>  133

<211>  309

<212>  PRT

<213>  Homo sapiens



<400>  133



Met Ser Leu Glu Gln Arg Ser Leu His Cys Lys Pro Glu Glu Ala Leu 

1               5                   10                  15      





Glu Ala Gln Gln Glu Ala Leu Gly Leu Val Cys Val Gln Ala Ala Thr 

            20                  25                  30          





Ser Ser Ser Ser Pro Leu Val Leu Gly Thr Leu Glu Glu Val Pro Thr 

        35                  40                  45              





Ala Gly Ser Thr Asp Pro Pro Gln Ser Pro Gln Gly Ala Ser Ala Phe 

    50                  55                  60                  





Pro Thr Thr Ile Asn Phe Thr Arg Gln Arg Gln Pro Ser Glu Gly Ser 

65                  70                  75                  80  





Ser Ser Arg Glu Glu Glu Gly Pro Ser Thr Ser Cys Ile Leu Glu Ser 

                85                  90                  95      





Leu Phe Arg Ala Val Ile Thr Lys Lys Val Ala Asp Leu Val Gly Phe 

            100                 105                 110         





Leu Leu Leu Lys Tyr Arg Ala Arg Glu Pro Val Thr Lys Ala Glu Met 

        115                 120                 125             





Leu Glu Ser Val Ile Lys Asn Tyr Lys His Cys Phe Pro Glu Ile Phe 

    130                 135                 140                 





Gly Lys Ala Ser Glu Ser Leu Gln Leu Val Phe Gly Ile Asp Val Lys 

145                 150                 155                 160 





Glu Ala Asp Pro Thr Gly His Ser Tyr Val Leu Val Thr Cys Leu Gly 

                165                 170                 175     





Leu Ser Tyr Asp Gly Leu Leu Gly Asp Asn Gln Ile Met Pro Lys Thr 

            180                 185                 190         





Gly Phe Leu Ile Ile Val Leu Val Met Ile Ala Met Glu Gly Gly His 

        195                 200                 205             





Ala Pro Glu Glu Glu Ile Trp Glu Glu Leu Ser Val Met Glu Val Tyr 

    210                 215                 220                 





Asp Gly Arg Glu His Ser Ala Tyr Gly Glu Pro Arg Lys Leu Leu Thr 

225                 230                 235                 240 





Gln Asp Leu Val Gln Glu Lys Tyr Leu Glu Tyr Arg Gln Val Pro Asp 

                245                 250                 255     





Ser Asp Pro Ala Arg Tyr Glu Phe Leu Trp Gly Pro Arg Ala Leu Ala 

            260                 265                 270         





Glu Thr Ser Tyr Val Lys Val Leu Glu Tyr Val Ile Lys Val Ser Ala 

        275                 280                 285             





Arg Val Arg Phe Phe Phe Pro Ser Leu Arg Glu Ala Ala Leu Arg Glu 

    290                 295                 300                 





Glu Glu Glu Gly Val 

305                 





<210>  134

<211>  314

<212>  PRT

<213>  Homo sapiens



<400>  134



Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu 

1               5                   10                  15      





Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala 

            20                  25                  30          





Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val 

        35                  40                  45              





Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser 

    50                  55                  60                  





Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp 

65                  70                  75                  80  





Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser 

                85                  90                  95      





Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys 

            100                 105                 110         





Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu 

        115                 120                 125             





Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln 

    130                 135                 140                 





Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu 

145                 150                 155                 160 





Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Leu Tyr 

                165                 170                 175     





Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp 

            180                 185                 190         





Asn Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val Leu Ala Ile 

        195                 200                 205             





Ile Ala Arg Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu 

    210                 215                 220                 





Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Leu Gly 

225                 230                 235                 240 





Asp Pro Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu 

                245                 250                 255     





Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu 

            260                 265                 270         





Trp Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Val Leu His 

        275                 280                 285             





His Met Val Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu 

    290                 295                 300                 





His Glu Trp Val Leu Arg Glu Gly Glu Glu 

305                 310                 





<210>  135

<211>  1225

<212>  PRT

<213>  Homo sapiens



<400>  135



Met Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu 

1               5                   10                  15      





Arg His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu 

            20                  25                  30          





Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln 

        35                  40                  45              





Glu Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val 

    50                  55                  60                  





Pro Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp 

65                  70                  75                  80  





Asn Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr 

                85                  90                  95      





Thr Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu 

            100                 105                 110         





Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn 

        115                 120                 125             





Pro Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His 

    130                 135                 140                 





Lys Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg 

145                 150                 155                 160 





Ala Cys His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly 

                165                 170                 175     





Glu Ser Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly 

            180                 185                 190         





Gly Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu 

        195                 200                 205             





Gln Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala 

    210                 215                 220                 





Cys Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala 

225                 230                 235                 240 





Leu Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu 

                245                 250                 255     





Gly Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn 

            260                 265                 270         





Tyr Leu Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His 

        275                 280                 285             





Asn Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys 

    290                 295                 300                 





Ser Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu 

305                 310                 315                 320 





Arg Glu Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly 

                325                 330                 335     





Cys Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp 

            340                 345                 350         





Gly Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln 

        355                 360                 365             





Val Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala 

    370                 375                 380                 





Trp Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val 

385                 390                 395                 400 





Ile Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln 

                405                 410                 415     





Gly Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly 

            420                 425                 430         





Ser Gly Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His 

        435                 440                 445             





Thr Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu 

    450                 455                 460                 





His Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala 

465                 470                 475                 480 





Cys His Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr 

                485                 490                 495     





Gln Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu 

            500                 505                 510         





Glu Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg 

        515                 520                 525             





His Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val 

    530                 535                 540                 





Thr Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr 

545                 550                 555                 560 





Lys Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro 

                565                 570                 575     





Asp Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala 

            580                 585                 590         





Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp 

        595                 600                 605             





Asp Lys Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile 

    610                 615                 620                 





Ile Ser Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val 

625                 630                 635                 640 





Phe Gly Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr 

                645                 650                 655     





Met Arg Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro 

            660                 665                 670         





Ser Gly Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr 

        675                 680                 685             





Glu Leu Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val 

    690                 695                 700                 





Tyr Lys Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val 

705                 710                 715                 720 





Ala Ile Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu 

                725                 730                 735     





Ile Leu Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val 

            740                 745                 750         





Ser Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr 

        755                 760                 765             





Gln Leu Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg 

    770                 775                 780                 





Gly Arg Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala 

785                 790                 795                 800 





Lys Gly Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu 

                805                 810                 815     





Ala Ala Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr 

            820                 825                 830         





Asp Phe Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His 

        835                 840                 845             





Ala Asp Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile 

    850                 855                 860                 





Leu Arg Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val 

865                 870                 875                 880 





Thr Val Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile 

                885                 890                 895     





Pro Ala Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro 

            900                 905                 910         





Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys 

        915                 920                 925             





Trp Met Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser 

    930                 935                 940                 





Glu Phe Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln 

945                 950                 955                 960 





Asn Glu Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg 

                965                 970                 975     





Ser Leu Leu Glu Asp Asp Asp Met Gly Asp Leu Val Asp Ala Glu Glu 

            980                 985                 990         





Tyr Leu Val Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 

        995                 1000                 1005             





Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 

    1010                 1015                 1020             





Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 

    1025                 1030                 1035             





Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 

    1040                 1045                 1050             





Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 

    1055                 1060                 1065             





Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 

    1070                 1075                 1080             





Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 

    1085                 1090                 1095             





Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 

    1100                 1105                 1110             





Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 

    1115                 1120                 1125             





Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 

    1130                 1135                 1140             





Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 

    1145                 1150                 1155             





Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 

    1160                 1165                 1170             





Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 

    1175                 1180                 1185             





Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 

    1190                 1195                 1200             





Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 

    1205                 1210                 1215             





Leu Gly  Leu Asp Val Pro Val  

    1220                 1225 





<210>  136

<211>  1240

<212>  PRT

<213>  Homo sapiens



<400>  136



Met Pro Arg Gly Ser Trp Lys Pro Gln Val Cys Thr Gly Thr Asp Met 

1               5                   10                  15      





Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg 

            20                  25                  30          





His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr 

        35                  40                  45              





Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu 

    50                  55                  60                  





Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro 

65                  70                  75                  80  





Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn 

                85                  90                  95      





Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr 

            100                 105                 110         





Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg 

        115                 120                 125             





Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro 

    130                 135                 140                 





Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys 

145                 150                 155                 160 





Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala 

                165                 170                 175     





Cys His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu 

            180                 185                 190         





Ser Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly 

        195                 200                 205             





Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln 

    210                 215                 220                 





Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys 

225                 230                 235                 240 





Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu 

                245                 250                 255     





Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly 

            260                 265                 270         





Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr 

        275                 280                 285             





Leu Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn 

    290                 295                 300                 





Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser 

305                 310                 315                 320 





Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg 

                325                 330                 335     





Glu Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys 

            340                 345                 350         





Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly 

        355                 360                 365             





Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val 

    370                 375                 380                 





Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp 

385                 390                 395                 400 





Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile 

                405                 410                 415     





Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly 

            420                 425                 430         





Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser 

        435                 440                 445             





Gly Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr 

    450                 455                 460                 





Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His 

465                 470                 475                 480 





Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys 

                485                 490                 495     





His Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln 

            500                 505                 510         





Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu 

        515                 520                 525             





Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His 

    530                 535                 540                 





Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr 

545                 550                 555                 560 





Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys 

                565                 570                 575     





Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp 

            580                 585                 590         





Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys 

        595                 600                 605             





Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp 

    610                 615                 620                 





Lys Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile 

625                 630                 635                 640 





Ser Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe 

                645                 650                 655     





Gly Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met 

            660                 665                 670         





Arg Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser 

        675                 680                 685             





Gly Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu 

    690                 695                 700                 





Leu Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr 

705                 710                 715                 720 





Lys Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala 

                725                 730                 735     





Ile Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile 

            740                 745                 750         





Leu Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser 

        755                 760                 765             





Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln 

    770                 775                 780                 





Leu Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly 

785                 790                 795                 800 





Arg Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys 

                805                 810                 815     





Gly Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala 

            820                 825                 830         





Ala Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp 

        835                 840                 845             





Phe Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala 

    850                 855                 860                 





Asp Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu 

865                 870                 875                 880 





Arg Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr 

                885                 890                 895     





Val Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro 

            900                 905                 910         





Ala Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln 

        915                 920                 925             





Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp 

    930                 935                 940                 





Met Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu 

945                 950                 955                 960 





Phe Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn 

                965                 970                 975     





Glu Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg Ser 

            980                 985                 990         





Leu Leu Glu Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr 

        995                 1000                 1005             





Leu Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 

    1010                 1015                 1020             





Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 

    1025                 1030                 1035             





Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 

    1040                 1045                 1050             





Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 

    1055                 1060                 1065             





Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 

    1070                 1075                 1080             





Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 

    1085                 1090                 1095             





Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 

    1100                 1105                 1110             





Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 

    1115                 1120                 1125             





Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 

    1130                 1135                 1140             





Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 

    1145                 1150                 1155             





Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 

    1160                 1165                 1170             





Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 

    1175                 1180                 1185             





Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 

    1190                 1195                 1200             





Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 

    1205                 1210                 1215             





Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 

    1220                 1225                 1230             





Leu Gly  Leu Asp Val Pro Val  

    1235                 1240 





<210>  137

<211>  1055

<212>  PRT

<213>  Homo sapiens



<400>  137



Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 

1               5                   10                  15      





Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 

            20                  25                  30          





Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 

        35                  40                  45              





Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 

    50                  55                  60                  





Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 

65                  70                  75                  80  





Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 

                85                  90                  95      





Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 

            100                 105                 110         





Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 

        115                 120                 125             





Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 

    130                 135                 140                 





Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 

145                 150                 155                 160 





Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 

                165                 170                 175     





Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 

            180                 185                 190         





His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 

        195                 200                 205             





Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 

    210                 215                 220                 





Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 

225                 230                 235                 240 





Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 

                245                 250                 255     





His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 

            260                 265                 270         





Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 

        275                 280                 285             





Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 

    290                 295                 300                 





Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 

305                 310                 315                 320 





Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 

                325                 330                 335     





Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 

            340                 345                 350         





Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 

        355                 360                 365             





Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 

    370                 375                 380                 





Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 

385                 390                 395                 400 





Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 

                405                 410                 415     





Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 

            420                 425                 430         





Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 

        435                 440                 445             





Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 

    450                 455                 460                 





Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 

465                 470                 475                 480 





Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 

                485                 490                 495     





Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 

            500                 505                 510         





Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 

        515                 520                 525             





Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 

    530                 535                 540                 





Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 

545                 550                 555                 560 





Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 

                565                 570                 575     





Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 

            580                 585                 590         





Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 

        595                 600                 605             





Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 

    610                 615                 620                 





Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 

625                 630                 635                 640 





Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 

                645                 650                 655     





Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 

            660                 665                 670         





Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg 

        675                 680                 685             





Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly 

    690                 695                 700                 





Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu 

705                 710                 715                 720 





Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 

                725                 730                 735     





Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile 

            740                 745                 750         





Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu 

        755                 760                 765             





Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg 

    770                 775                 780                 





Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu 

785                 790                 795                 800 





Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg 

                805                 810                 815     





Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly 

            820                 825                 830         





Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala 

        835                 840                 845             





Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe 

    850                 855                 860                 





Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp 

865                 870                 875                 880 





Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg 

                885                 890                 895     





Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val 

            900                 905                 910         





Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala 

        915                 920                 925             





Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro 

    930                 935                 940                 





Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met 

945                 950                 955                 960 





Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe 

                965                 970                 975     





Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu 

            980                 985                 990         





Asp Leu Gly Pro Ala Ser Pro Leu  Asp Ser Thr Phe Tyr  Arg Ser Leu 

        995                 1000                 1005             





Leu Glu  Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr 

    1010                 1015                 1020             





Leu Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 

    1025                 1030                 1035             





Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 

    1040                 1045                 1050             





Asn Met  

    1055 





<210>  138

<211>  603

<212>  PRT

<213>  Homo sapiens



<400>  138



Met Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu 

1               5                   10                  15      





Arg His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu 

            20                  25                  30          





Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln 

        35                  40                  45              





Glu Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val 

    50                  55                  60                  





Pro Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp 

65                  70                  75                  80  





Asn Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr 

                85                  90                  95      





Thr Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu 

            100                 105                 110         





Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn 

        115                 120                 125             





Pro Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His 

    130                 135                 140                 





Lys Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg 

145                 150                 155                 160 





Ala Cys His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly 

                165                 170                 175     





Glu Ser Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly 

            180                 185                 190         





Gly Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu 

        195                 200                 205             





Gln Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala 

    210                 215                 220                 





Cys Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala 

225                 230                 235                 240 





Leu Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu 

                245                 250                 255     





Gly Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn 

            260                 265                 270         





Tyr Leu Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His 

        275                 280                 285             





Asn Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys 

    290                 295                 300                 





Ser Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu 

305                 310                 315                 320 





Arg Glu Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly 

                325                 330                 335     





Cys Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp 

            340                 345                 350         





Gly Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln 

        355                 360                 365             





Val Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala 

    370                 375                 380                 





Trp Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val 

385                 390                 395                 400 





Ile Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln 

                405                 410                 415     





Gly Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly 

            420                 425                 430         





Ser Gly Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His 

        435                 440                 445             





Thr Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu 

    450                 455                 460                 





His Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala 

465                 470                 475                 480 





Cys His Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr 

                485                 490                 495     





Gln Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu 

            500                 505                 510         





Glu Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg 

        515                 520                 525             





His Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val 

    530                 535                 540                 





Thr Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr 

545                 550                 555                 560 





Lys Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro 

                565                 570                 575     





Asp Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala 

            580                 585                 590         





Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser 

        595                 600             





<210>  139

<211>  1255

<212>  PRT

<213>  Homo sapiens



<400>  139



Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 

1               5                   10                  15      





Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 

            20                  25                  30          





Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 

        35                  40                  45              





Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 

    50                  55                  60                  





Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 

65                  70                  75                  80  





Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 

                85                  90                  95      





Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 

            100                 105                 110         





Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 

        115                 120                 125             





Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 

    130                 135                 140                 





Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 

145                 150                 155                 160 





Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 

                165                 170                 175     





Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 

            180                 185                 190         





His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 

        195                 200                 205             





Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 

    210                 215                 220                 





Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 

225                 230                 235                 240 





Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 

                245                 250                 255     





His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 

            260                 265                 270         





Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 

        275                 280                 285             





Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 

    290                 295                 300                 





Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 

305                 310                 315                 320 





Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 

                325                 330                 335     





Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 

            340                 345                 350         





Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 

        355                 360                 365             





Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 

    370                 375                 380                 





Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 

385                 390                 395                 400 





Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 

                405                 410                 415     





Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 

            420                 425                 430         





Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 

        435                 440                 445             





Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 

    450                 455                 460                 





Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 

465                 470                 475                 480 





Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 

                485                 490                 495     





Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 

            500                 505                 510         





Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 

        515                 520                 525             





Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 

    530                 535                 540                 





Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 

545                 550                 555                 560 





Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 

                565                 570                 575     





Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 

            580                 585                 590         





Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 

        595                 600                 605             





Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 

    610                 615                 620                 





Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 

625                 630                 635                 640 





Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 

                645                 650                 655     





Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 

            660                 665                 670         





Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg 

        675                 680                 685             





Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly 

    690                 695                 700                 





Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu 

705                 710                 715                 720 





Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 

                725                 730                 735     





Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile 

            740                 745                 750         





Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu 

        755                 760                 765             





Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg 

    770                 775                 780                 





Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu 

785                 790                 795                 800 





Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg 

                805                 810                 815     





Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly 

            820                 825                 830         





Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala 

        835                 840                 845             





Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe 

    850                 855                 860                 





Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp 

865                 870                 875                 880 





Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg 

                885                 890                 895     





Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val 

            900                 905                 910         





Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala 

        915                 920                 925             





Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro 

    930                 935                 940                 





Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met 

945                 950                 955                 960 





Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe 

                965                 970                 975     





Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu 

            980                 985                 990         





Asp Leu Gly Pro Ala Ser Pro Leu  Asp Ser Thr Phe Tyr  Arg Ser Leu 

        995                 1000                 1005             





Leu Glu  Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr 

    1010                 1015                 1020             





Leu Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 

    1025                 1030                 1035             





Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 

    1040                 1045                 1050             





Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 

    1055                 1060                 1065             





Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 

    1070                 1075                 1080             





Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 

    1085                 1090                 1095             





Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 

    1100                 1105                 1110             





Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 

    1115                 1120                 1125             





Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 

    1130                 1135                 1140             





Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 

    1145                 1150                 1155             





Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 

    1160                 1165                 1170             





Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 

    1175                 1180                 1185             





Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 

    1190                 1195                 1200             





Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 

    1205                 1210                 1215             





Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 

    1220                 1225                 1230             





Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 

    1235                 1240                 1245             





Leu Gly  Leu Asp Val Pro Val  

    1250                 1255 





<210>  140

<211>  781

<212>  PRT

<213>  Homo sapiens



<400>  140



Met Ala Thr Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro 

1               5                   10                  15      





Asp Arg Lys Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp 

            20                  25                  30          





Ser Gly Ile His Ser Gly Ala Thr Thr Thr Ala Pro Ser Leu Ser Gly 

        35                  40                  45              





Lys Gly Asn Pro Glu Glu Glu Asp Val Asp Thr Ser Gln Val Leu Tyr 

    50                  55                  60                  





Glu Trp Glu Gln Gly Phe Ser Gln Ser Phe Thr Gln Glu Gln Val Ala 

65                  70                  75                  80  





Asp Ile Asp Gly Gln Tyr Ala Met Thr Arg Ala Gln Arg Val Arg Ala 

                85                  90                  95      





Ala Met Phe Pro Glu Thr Leu Asp Glu Gly Met Gln Ile Pro Ser Thr 

            100                 105                 110         





Gln Phe Asp Ala Ala His Pro Thr Asn Val Gln Arg Leu Ala Glu Pro 

        115                 120                 125             





Ser Gln Met Leu Lys His Ala Val Val Asn Leu Ile Asn Tyr Gln Asp 

    130                 135                 140                 





Asp Ala Glu Leu Ala Thr Arg Ala Ile Pro Glu Leu Thr Lys Leu Leu 

145                 150                 155                 160 





Asn Asp Glu Asp Gln Val Val Val Asn Lys Ala Ala Val Met Val His 

                165                 170                 175     





Gln Leu Ser Lys Lys Glu Ala Ser Arg His Ala Ile Met Arg Ser Pro 

            180                 185                 190         





Gln Met Val Ser Ala Ile Val Arg Thr Met Gln Asn Thr Asn Asp Val 

        195                 200                 205             





Glu Thr Ala Arg Cys Thr Ala Gly Thr Leu His Asn Leu Ser His His 

    210                 215                 220                 





Arg Glu Gly Leu Leu Ala Ile Phe Lys Ser Gly Gly Ile Pro Ala Leu 

225                 230                 235                 240 





Val Lys Met Leu Gly Ser Pro Val Asp Ser Val Leu Phe Tyr Ala Ile 

                245                 250                 255     





Thr Thr Leu His Asn Leu Leu Leu His Gln Glu Gly Ala Lys Met Ala 

            260                 265                 270         





Val Arg Leu Ala Gly Gly Leu Gln Lys Met Val Ala Leu Leu Asn Lys 

        275                 280                 285             





Thr Asn Val Lys Phe Leu Ala Ile Thr Thr Asp Cys Leu Gln Ile Leu 

    290                 295                 300                 





Ala Tyr Gly Asn Gln Glu Ser Lys Leu Ile Ile Leu Ala Ser Gly Gly 

305                 310                 315                 320 





Pro Gln Ala Leu Val Asn Ile Met Arg Thr Tyr Thr Tyr Glu Lys Leu 

                325                 330                 335     





Leu Trp Thr Thr Ser Arg Val Leu Lys Val Leu Ser Val Cys Ser Ser 

            340                 345                 350         





Asn Lys Pro Ala Ile Val Glu Ala Gly Gly Met Gln Ala Leu Gly Leu 

        355                 360                 365             





His Leu Thr Asp Pro Ser Gln Arg Leu Val Gln Asn Cys Leu Trp Thr 

    370                 375                 380                 





Leu Arg Asn Leu Ser Asp Ala Ala Thr Lys Gln Glu Gly Met Glu Gly 

385                 390                 395                 400 





Leu Leu Gly Thr Leu Val Gln Leu Leu Gly Ser Asp Asp Ile Asn Val 

                405                 410                 415     





Val Thr Cys Ala Ala Gly Ile Leu Ser Asn Leu Thr Cys Asn Asn Tyr 

            420                 425                 430         





Lys Asn Lys Met Met Val Cys Gln Val Gly Gly Ile Glu Ala Leu Val 

        435                 440                 445             





Arg Thr Val Leu Arg Ala Gly Asp Arg Glu Asp Ile Thr Glu Pro Ala 

    450                 455                 460                 





Ile Cys Ala Leu Arg His Leu Thr Ser Arg His Gln Glu Ala Glu Met 

465                 470                 475                 480 





Ala Gln Asn Ala Val Arg Leu His Tyr Gly Leu Pro Val Val Val Lys 

                485                 490                 495     





Leu Leu His Pro Pro Ser His Trp Pro Leu Ile Lys Ala Thr Val Gly 

            500                 505                 510         





Leu Ile Arg Asn Leu Ala Leu Cys Pro Ala Asn His Ala Pro Leu Arg 

        515                 520                 525             





Glu Gln Gly Ala Ile Pro Arg Leu Val Gln Leu Leu Val Arg Ala His 

    530                 535                 540                 





Gln Asp Thr Gln Arg Arg Thr Ser Met Gly Gly Thr Gln Gln Gln Phe 

545                 550                 555                 560 





Val Glu Gly Val Arg Met Glu Glu Ile Val Glu Gly Cys Thr Gly Ala 

                565                 570                 575     





Leu His Ile Leu Ala Arg Asp Val His Asn Arg Ile Val Ile Arg Gly 

            580                 585                 590         





Leu Asn Thr Ile Pro Leu Phe Val Gln Leu Leu Tyr Ser Pro Ile Glu 

        595                 600                 605             





Asn Ile Gln Arg Val Ala Ala Gly Val Leu Cys Glu Leu Ala Gln Asp 

    610                 615                 620                 





Lys Glu Ala Ala Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu 

625                 630                 635                 640 





Thr Glu Leu Leu His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala 

                645                 650                 655     





Ala Val Leu Phe Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys 

            660                 665                 670         





Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met 

        675                 680                 685             





Ala Trp Asn Glu Thr Ala Asp Leu Gly Leu Asp Ile Gly Ala Gln Gly 

    690                 695                 700                 





Glu Pro Leu Gly Tyr Arg Gln Asp Asp Pro Ser Tyr Arg Ser Phe His 

705                 710                 715                 720 





Ser Gly Gly Tyr Gly Gln Asp Ala Leu Gly Met Asp Pro Met Met Glu 

                725                 730                 735     





His Glu Met Gly Gly His His Pro Gly Ala Asp Tyr Pro Val Asp Gly 

            740                 745                 750         





Leu Pro Asp Leu Gly His Ala Gln Asp Leu Met Asp Gly Leu Pro Pro 

        755                 760                 765             





Gly Asp Ser Asn Gln Leu Ala Trp Phe Asp Thr Asp Leu 

    770                 775                 780     





<210>  141

<211>  781

<212>  PRT

<213>  Homo sapiens



<400>  141



Met Ala Thr Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro 

1               5                   10                  15      





Asp Arg Lys Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp 

            20                  25                  30          





Ser Gly Ile His Ser Gly Ala Thr Thr Thr Ala Pro Ser Leu Ser Gly 

        35                  40                  45              





Lys Gly Asn Pro Glu Glu Glu Asp Val Asp Thr Ser Gln Val Leu Tyr 

    50                  55                  60                  





Glu Trp Glu Gln Gly Phe Ser Gln Ser Phe Thr Gln Glu Gln Val Ala 

65                  70                  75                  80  





Asp Ile Asp Gly Gln Tyr Ala Met Thr Arg Ala Gln Arg Val Arg Ala 

                85                  90                  95      





Ala Met Phe Pro Glu Thr Leu Asp Glu Gly Met Gln Ile Pro Ser Thr 

            100                 105                 110         





Gln Phe Asp Ala Ala His Pro Thr Asn Val Gln Arg Leu Ala Glu Pro 

        115                 120                 125             





Ser Gln Met Leu Lys His Ala Val Val Asn Leu Ile Asn Tyr Gln Asp 

    130                 135                 140                 





Asp Ala Glu Leu Ala Thr Arg Ala Ile Pro Glu Leu Thr Lys Leu Leu 

145                 150                 155                 160 





Asn Asp Glu Asp Gln Val Val Val Asn Lys Ala Ala Val Met Val His 

                165                 170                 175     





Gln Leu Ser Lys Lys Glu Ala Ser Arg His Ala Ile Met Arg Ser Pro 

            180                 185                 190         





Gln Met Val Ser Ala Ile Val Arg Thr Met Gln Asn Thr Asn Asp Val 

        195                 200                 205             





Glu Thr Ala Arg Cys Thr Ala Gly Thr Leu His Asn Leu Ser His His 

    210                 215                 220                 





Arg Glu Gly Leu Leu Ala Ile Phe Lys Ser Gly Gly Ile Pro Ala Leu 

225                 230                 235                 240 





Val Lys Met Leu Gly Ser Pro Val Asp Ser Val Leu Phe Tyr Ala Ile 

                245                 250                 255     





Thr Thr Leu His Asn Leu Leu Leu His Gln Glu Gly Ala Lys Met Ala 

            260                 265                 270         





Val Arg Leu Ala Gly Gly Leu Gln Lys Met Val Ala Leu Leu Asn Lys 

        275                 280                 285             





Thr Asn Val Lys Phe Leu Ala Ile Thr Thr Asp Cys Leu Gln Ile Leu 

    290                 295                 300                 





Ala Tyr Gly Asn Gln Glu Ser Lys Leu Ile Ile Leu Ala Ser Gly Gly 

305                 310                 315                 320 





Pro Gln Ala Leu Val Asn Ile Met Arg Thr Tyr Thr Tyr Glu Lys Leu 

                325                 330                 335     





Leu Trp Thr Thr Ser Arg Val Leu Lys Val Leu Ser Val Cys Ser Ser 

            340                 345                 350         





Asn Lys Pro Ala Ile Val Glu Ala Gly Gly Met Gln Ala Leu Gly Leu 

        355                 360                 365             





His Leu Thr Asp Pro Ser Gln Arg Leu Val Gln Asn Cys Leu Trp Thr 

    370                 375                 380                 





Leu Arg Asn Leu Ser Asp Ala Ala Thr Lys Gln Glu Gly Met Glu Gly 

385                 390                 395                 400 





Leu Leu Gly Thr Leu Val Gln Leu Leu Gly Ser Asp Asp Ile Asn Val 

                405                 410                 415     





Val Thr Cys Ala Ala Gly Ile Leu Ser Asn Leu Thr Cys Asn Asn Tyr 

            420                 425                 430         





Lys Asn Lys Met Met Val Cys Gln Val Gly Gly Ile Glu Ala Leu Val 

        435                 440                 445             





Arg Thr Val Leu Arg Ala Gly Asp Arg Glu Asp Ile Thr Glu Pro Ala 

    450                 455                 460                 





Ile Cys Ala Leu Arg His Leu Thr Ser Arg His Gln Glu Ala Glu Met 

465                 470                 475                 480 





Ala Gln Asn Ala Val Arg Leu His Tyr Gly Leu Pro Val Val Val Lys 

                485                 490                 495     





Leu Leu His Pro Pro Ser His Trp Pro Leu Ile Lys Ala Thr Val Gly 

            500                 505                 510         





Leu Ile Arg Asn Leu Ala Leu Cys Pro Ala Asn His Ala Pro Leu Arg 

        515                 520                 525             





Glu Gln Gly Ala Ile Pro Arg Leu Val Gln Leu Leu Val Arg Ala His 

    530                 535                 540                 





Gln Asp Thr Gln Arg Arg Thr Ser Met Gly Gly Thr Gln Gln Gln Phe 

545                 550                 555                 560 





Val Glu Gly Val Arg Met Glu Glu Ile Val Glu Gly Cys Thr Gly Ala 

                565                 570                 575     





Leu His Ile Leu Ala Arg Asp Val His Asn Arg Ile Val Ile Arg Gly 

            580                 585                 590         





Leu Asn Thr Ile Pro Leu Phe Val Gln Leu Leu Tyr Ser Pro Ile Glu 

        595                 600                 605             





Asn Ile Gln Arg Val Ala Ala Gly Val Leu Cys Glu Leu Ala Gln Asp 

    610                 615                 620                 





Lys Glu Ala Ala Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu 

625                 630                 635                 640 





Thr Glu Leu Leu His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala 

                645                 650                 655     





Ala Val Leu Phe Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys 

            660                 665                 670         





Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met 

        675                 680                 685             





Ala Trp Asn Glu Thr Ala Asp Leu Gly Leu Asp Ile Gly Ala Gln Gly 

    690                 695                 700                 





Glu Pro Leu Gly Tyr Arg Gln Asp Asp Pro Ser Tyr Arg Ser Phe His 

705                 710                 715                 720 





Ser Gly Gly Tyr Gly Gln Asp Ala Leu Gly Met Asp Pro Met Met Glu 

                725                 730                 735     





His Glu Met Gly Gly His His Pro Gly Ala Asp Tyr Pro Val Asp Gly 

            740                 745                 750         





Leu Pro Asp Leu Gly His Ala Gln Asp Leu Met Asp Gly Leu Pro Pro 

        755                 760                 765             





Gly Asp Ser Asn Gln Leu Ala Trp Phe Asp Thr Asp Leu 

    770                 775                 780     





<210>  142

<211>  781

<212>  PRT

<213>  Homo sapiens



<400>  142



Met Ala Thr Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro 

1               5                   10                  15      





Asp Arg Lys Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp 

            20                  25                  30          





Ser Gly Ile His Ser Gly Ala Thr Thr Thr Ala Pro Ser Leu Ser Gly 

        35                  40                  45              





Lys Gly Asn Pro Glu Glu Glu Asp Val Asp Thr Ser Gln Val Leu Tyr 

    50                  55                  60                  





Glu Trp Glu Gln Gly Phe Ser Gln Ser Phe Thr Gln Glu Gln Val Ala 

65                  70                  75                  80  





Asp Ile Asp Gly Gln Tyr Ala Met Thr Arg Ala Gln Arg Val Arg Ala 

                85                  90                  95      





Ala Met Phe Pro Glu Thr Leu Asp Glu Gly Met Gln Ile Pro Ser Thr 

            100                 105                 110         





Gln Phe Asp Ala Ala His Pro Thr Asn Val Gln Arg Leu Ala Glu Pro 

        115                 120                 125             





Ser Gln Met Leu Lys His Ala Val Val Asn Leu Ile Asn Tyr Gln Asp 

    130                 135                 140                 





Asp Ala Glu Leu Ala Thr Arg Ala Ile Pro Glu Leu Thr Lys Leu Leu 

145                 150                 155                 160 





Asn Asp Glu Asp Gln Val Val Val Asn Lys Ala Ala Val Met Val His 

                165                 170                 175     





Gln Leu Ser Lys Lys Glu Ala Ser Arg His Ala Ile Met Arg Ser Pro 

            180                 185                 190         





Gln Met Val Ser Ala Ile Val Arg Thr Met Gln Asn Thr Asn Asp Val 

        195                 200                 205             





Glu Thr Ala Arg Cys Thr Ala Gly Thr Leu His Asn Leu Ser His His 

    210                 215                 220                 





Arg Glu Gly Leu Leu Ala Ile Phe Lys Ser Gly Gly Ile Pro Ala Leu 

225                 230                 235                 240 





Val Lys Met Leu Gly Ser Pro Val Asp Ser Val Leu Phe Tyr Ala Ile 

                245                 250                 255     





Thr Thr Leu His Asn Leu Leu Leu His Gln Glu Gly Ala Lys Met Ala 

            260                 265                 270         





Val Arg Leu Ala Gly Gly Leu Gln Lys Met Val Ala Leu Leu Asn Lys 

        275                 280                 285             





Thr Asn Val Lys Phe Leu Ala Ile Thr Thr Asp Cys Leu Gln Ile Leu 

    290                 295                 300                 





Ala Tyr Gly Asn Gln Glu Ser Lys Leu Ile Ile Leu Ala Ser Gly Gly 

305                 310                 315                 320 





Pro Gln Ala Leu Val Asn Ile Met Arg Thr Tyr Thr Tyr Glu Lys Leu 

                325                 330                 335     





Leu Trp Thr Thr Ser Arg Val Leu Lys Val Leu Ser Val Cys Ser Ser 

            340                 345                 350         





Asn Lys Pro Ala Ile Val Glu Ala Gly Gly Met Gln Ala Leu Gly Leu 

        355                 360                 365             





His Leu Thr Asp Pro Ser Gln Arg Leu Val Gln Asn Cys Leu Trp Thr 

    370                 375                 380                 





Leu Arg Asn Leu Ser Asp Ala Ala Thr Lys Gln Glu Gly Met Glu Gly 

385                 390                 395                 400 





Leu Leu Gly Thr Leu Val Gln Leu Leu Gly Ser Asp Asp Ile Asn Val 

                405                 410                 415     





Val Thr Cys Ala Ala Gly Ile Leu Ser Asn Leu Thr Cys Asn Asn Tyr 

            420                 425                 430         





Lys Asn Lys Met Met Val Cys Gln Val Gly Gly Ile Glu Ala Leu Val 

        435                 440                 445             





Arg Thr Val Leu Arg Ala Gly Asp Arg Glu Asp Ile Thr Glu Pro Ala 

    450                 455                 460                 





Ile Cys Ala Leu Arg His Leu Thr Ser Arg His Gln Glu Ala Glu Met 

465                 470                 475                 480 





Ala Gln Asn Ala Val Arg Leu His Tyr Gly Leu Pro Val Val Val Lys 

                485                 490                 495     





Leu Leu His Pro Pro Ser His Trp Pro Leu Ile Lys Ala Thr Val Gly 

            500                 505                 510         





Leu Ile Arg Asn Leu Ala Leu Cys Pro Ala Asn His Ala Pro Leu Arg 

        515                 520                 525             





Glu Gln Gly Ala Ile Pro Arg Leu Val Gln Leu Leu Val Arg Ala His 

    530                 535                 540                 





Gln Asp Thr Gln Arg Arg Thr Ser Met Gly Gly Thr Gln Gln Gln Phe 

545                 550                 555                 560 





Val Glu Gly Val Arg Met Glu Glu Ile Val Glu Gly Cys Thr Gly Ala 

                565                 570                 575     





Leu His Ile Leu Ala Arg Asp Val His Asn Arg Ile Val Ile Arg Gly 

            580                 585                 590         





Leu Asn Thr Ile Pro Leu Phe Val Gln Leu Leu Tyr Ser Pro Ile Glu 

        595                 600                 605             





Asn Ile Gln Arg Val Ala Ala Gly Val Leu Cys Glu Leu Ala Gln Asp 

    610                 615                 620                 





Lys Glu Ala Ala Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu 

625                 630                 635                 640 





Thr Glu Leu Leu His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala 

                645                 650                 655     





Ala Val Leu Phe Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys 

            660                 665                 670         





Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met 

        675                 680                 685             





Ala Trp Asn Glu Thr Ala Asp Leu Gly Leu Asp Ile Gly Ala Gln Gly 

    690                 695                 700                 





Glu Pro Leu Gly Tyr Arg Gln Asp Asp Pro Ser Tyr Arg Ser Phe His 

705                 710                 715                 720 





Ser Gly Gly Tyr Gly Gln Asp Ala Leu Gly Met Asp Pro Met Met Glu 

                725                 730                 735     





His Glu Met Gly Gly His His Pro Gly Ala Asp Tyr Pro Val Asp Gly 

            740                 745                 750         





Leu Pro Asp Leu Gly His Ala Gln Asp Leu Met Asp Gly Leu Pro Pro 

        755                 760                 765             





Gly Asp Ser Asn Gln Leu Ala Trp Phe Asp Thr Asp Leu 

    770                 775                 780     





<210>  143

<211>  529

<212>  PRT

<213>  Homo sapiens



<400>  143



Met Leu Leu Ala Val Leu Tyr Cys Leu Leu Trp Ser Phe Gln Thr Ser 

1               5                   10                  15      





Ala Gly His Phe Pro Arg Ala Cys Val Ser Ser Lys Asn Leu Met Glu 

            20                  25                  30          





Lys Glu Cys Cys Pro Pro Trp Ser Gly Asp Arg Ser Pro Cys Gly Gln 

        35                  40                  45              





Leu Ser Gly Arg Gly Ser Cys Gln Asn Ile Leu Leu Ser Asn Ala Pro 

    50                  55                  60                  





Leu Gly Pro Gln Phe Pro Phe Thr Gly Val Asp Asp Arg Glu Ser Trp 

65                  70                  75                  80  





Pro Ser Val Phe Tyr Asn Arg Thr Cys Gln Cys Ser Gly Asn Phe Met 

                85                  90                  95      





Gly Phe Asn Cys Gly Asn Cys Lys Phe Gly Phe Trp Gly Pro Asn Cys 

            100                 105                 110         





Thr Glu Arg Arg Leu Leu Val Arg Arg Asn Ile Phe Asp Leu Ser Ala 

        115                 120                 125             





Pro Glu Lys Asp Lys Phe Phe Ala Tyr Leu Thr Leu Ala Lys His Thr 

    130                 135                 140                 





Ile Ser Ser Asp Tyr Val Ile Pro Ile Gly Thr Tyr Gly Gln Met Lys 

145                 150                 155                 160 





Asn Gly Ser Thr Pro Met Phe Asn Asp Ile Asn Ile Tyr Asp Leu Phe 

                165                 170                 175     





Val Trp Met His Tyr Tyr Val Ser Met Asp Ala Leu Leu Gly Gly Ser 

            180                 185                 190         





Glu Ile Trp Arg Asp Ile Asp Phe Ala His Glu Ala Pro Ala Phe Leu 

        195                 200                 205             





Pro Trp His Arg Leu Phe Leu Leu Arg Trp Glu Gln Glu Ile Gln Lys 

    210                 215                 220                 





Leu Thr Gly Asp Glu Asn Phe Thr Ile Pro Tyr Trp Asp Trp Arg Asp 

225                 230                 235                 240 





Ala Glu Lys Cys Asp Ile Cys Thr Asp Glu Tyr Met Gly Gly Gln His 

                245                 250                 255     





Pro Thr Asn Pro Asn Leu Leu Ser Pro Ala Ser Phe Phe Ser Ser Trp 

            260                 265                 270         





Gln Ile Val Cys Ser Arg Leu Glu Glu Tyr Asn Ser His Gln Ser Leu 

        275                 280                 285             





Cys Asn Gly Thr Pro Glu Gly Pro Leu Arg Arg Asn Pro Gly Asn His 

    290                 295                 300                 





Asp Lys Ser Arg Thr Pro Arg Leu Pro Ser Ser Ala Asp Val Glu Phe 

305                 310                 315                 320 





Cys Leu Ser Leu Thr Gln Tyr Glu Ser Gly Ser Met Asp Lys Ala Ala 

                325                 330                 335     





Asn Phe Ser Phe Arg Asn Thr Leu Glu Gly Phe Ala Ser Pro Leu Thr 

            340                 345                 350         





Gly Ile Ala Asp Ala Ser Gln Ser Ser Met His Asn Ala Leu His Ile 

        355                 360                 365             





Tyr Met Asn Gly Thr Met Ser Gln Val Gln Gly Ser Ala Asn Asp Pro 

    370                 375                 380                 





Ile Phe Leu Leu His His Ala Phe Val Asp Ser Ile Phe Glu Gln Trp 

385                 390                 395                 400 





Leu Arg Arg His Arg Pro Leu Gln Glu Val Tyr Pro Glu Ala Asn Ala 

                405                 410                 415     





Pro Ile Gly His Asn Arg Glu Ser Tyr Met Val Pro Phe Ile Pro Leu 

            420                 425                 430         





Tyr Arg Asn Gly Asp Phe Phe Ile Ser Ser Lys Asp Leu Gly Tyr Asp 

        435                 440                 445             





Tyr Ser Tyr Leu Gln Asp Ser Asp Pro Asp Ser Phe Gln Asp Tyr Ile 

    450                 455                 460                 





Lys Ser Tyr Leu Glu Gln Ala Ser Arg Ile Trp Ser Trp Leu Leu Gly 

465                 470                 475                 480 





Ala Ala Met Val Gly Ala Val Leu Thr Ala Leu Leu Ala Gly Leu Val 

                485                 490                 495     





Ser Leu Leu Cys Arg His Lys Arg Lys Gln Leu Pro Glu Glu Lys Gln 

            500                 505                 510         





Pro Leu Leu Met Glu Lys Glu Asp Tyr His Ser Leu Tyr Gln Ser His 

        515                 520                 525             





Leu 

    





<210>  144

<211>  693

<212>  PRT

<213>  Homo sapiens



<400>  144



Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 

1               5                   10                  15      





Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 

            20                  25                  30          





Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 

        35                  40                  45              





Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Thr Leu Leu Ala 

    50                  55                  60                  





Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 

65                  70                  75                  80  





Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 

                85                  90                  95      





Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 

            100                 105                 110         





Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 

        115                 120                 125             





Gly Thr Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 

    130                 135                 140                 





Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 

145                 150                 155                 160 





Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 

                165                 170                 175     





Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 

            180                 185                 190         





Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 

        195                 200                 205             





Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 

    210                 215                 220                 





Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 

225                 230                 235                 240 





Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 

                245                 250                 255     





Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 

            260                 265                 270         





Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Met Met 

        275                 280                 285             





Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Thr Ser Glu 

    290                 295                 300                 





Gln Glu Lys Arg Leu Thr Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 

305                 310                 315                 320 





Phe Glu Asp Cys Gly Gly Gly Tyr Thr Pro Asp Cys Ser Ser Asn Glu 

                325                 330                 335     





Asn Leu Thr Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 

            340                 345                 350         





Val Ser Pro Ser Pro Thr Thr Tyr Arg Met Phe Arg Asp Lys Ser Arg 

        355                 360                 365             





Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 

    370                 375                 380                 





Thr Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 

385                 390                 395                 400 





Glu Ala Thr Ile Val Gly Val Arg Lys Thr Gly Gln Ile Trp Pro Asn 

                405                 410                 415     





Asp Gly Glu Gly Ala Phe His Gly Asp Ala Asp Gly Ser Phe Gly Thr 

            420                 425                 430         





Pro Pro Gly Tyr Gly Cys Ala Ala Asp Arg Ala Glu Glu Gln Arg Arg 

        435                 440                 445             





His Gln Asp Gly Leu Pro Tyr Ile Asp Asp Ser Pro Ser Ser Ser Pro 

    450                 455                 460                 





His Leu Ser Ser Lys Gly Arg Gly Ser Arg Asp Ala Leu Val Ser Gly 

465                 470                 475                 480 





Ala Leu Glu Ser Thr Lys Ala Ser Glu Leu Asp Leu Glu Lys Gly Leu 

                485                 490                 495     





Glu Met Arg Lys Trp Val Leu Ser Gly Ile Leu Ala Ser Glu Glu Thr 

            500                 505                 510         





Tyr Leu Ser His Leu Glu Ala Leu Leu Leu Pro Met Lys Pro Leu Lys 

        515                 520                 525             





Ala Ala Ala Thr Thr Ser Gln Pro Val Leu Thr Ser Gln Gln Ile Glu 

    530                 535                 540                 





Thr Ile Phe Phe Lys Val Pro Glu Leu Tyr Glu Ile His Lys Glu Phe 

545                 550                 555                 560 





Tyr Asp Gly Leu Phe Pro Arg Val Gln Gln Trp Ser His Gln Gln Arg 

                565                 570                 575     





Val Gly Asp Leu Phe Gln Lys Leu Ala Ser Gln Leu Gly Val Tyr Arg 

            580                 585                 590         





Ala Phe Val Asp Asn Tyr Gly Val Ala Met Glu Met Ala Glu Lys Cys 

        595                 600                 605             





Cys Gln Ala Asn Ala Gln Phe Ala Glu Ile Ser Glu Asn Leu Arg Ala 

    610                 615                 620                 





Arg Ser Asn Lys Asp Ala Lys Asp Pro Thr Thr Lys Asn Ser Leu Glu 

625                 630                 635                 640 





Thr Leu Leu Tyr Lys Pro Val Asp Arg Val Thr Arg Ser Thr Leu Val 

                645                 650                 655     





Leu His Asp Leu Leu Lys His Thr Pro Ala Ser His Pro Asp His Pro 

            660                 665                 670         





Leu Leu Gln Asp Ala Leu Arg Ile Ser Gln Asn Phe Leu Ser Ser Ile 

        675                 680                 685             





Asn Glu Glu Ile Thr 

    690             





<210>  145

<211>  464

<212>  PRT

<213>  Homo sapiens



<400>  145



Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 

1               5                   10                  15      





Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 

            20                  25                  30          





Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 

        35                  40                  45              





Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 

    50                  55                  60                  





Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn 

65                  70                  75                  80  





Thr Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala 

                85                  90                  95      





Gln Ile Ser Ala Tyr Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 

            100                 105                 110         





Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 

        115                 120                 125             





Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 

    130                 135                 140                 





Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 

145                 150                 155                 160 





Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 

                165                 170                 175     





Asp Tyr Glu Glu Phe Ser Lys Gly Glu Glu Leu Cys Gly Val Met Thr 

            180                 185                 190         





Ile Ser Asp Ser Pro Arg Glu Gln Asp Ser Glu Ser Gln Thr Leu Asp 

        195                 200                 205             





Lys Val Tyr Gln Met Lys Ser Lys Pro Arg Gly Tyr Cys Leu Ile Ile 

    210                 215                 220                 





Asn Asn His Asn Phe Ala Lys Ala Arg Glu Lys Val Pro Lys Leu His 

225                 230                 235                 240 





Ser Ile Arg Asp Arg Asn Gly Thr His Leu Asp Ala Gly Ala Leu Thr 

                245                 250                 255     





Thr Thr Phe Glu Glu Leu His Phe Glu Ile Lys Pro His Asp Asp Cys 

            260                 265                 270         





Thr Val Glu Gln Ile Tyr Glu Ile Leu Lys Ile Tyr Gln Leu Met Asp 

        275                 280                 285             





His Ser Asn Met Asp Cys Phe Ile Cys Cys Ile Leu Ser His Gly Asp 

    290                 295                 300                 





Lys Gly Ile Ile Tyr Gly Thr Asp Gly Gln Glu Ala Pro Ile Tyr Glu 

305                 310                 315                 320 





Leu Thr Ser Gln Phe Thr Gly Leu Lys Cys Pro Ser Leu Ala Gly Lys 

                325                 330                 335     





Pro Lys Val Phe Phe Ile Gln Ala Cys Gln Gly Asp Asn Tyr Gln Lys 

            340                 345                 350         





Gly Ile Pro Val Glu Thr Asp Ser Glu Glu Gln Pro Tyr Leu Glu Met 

        355                 360                 365             





Asp Leu Ser Ser Pro Gln Thr Arg Tyr Ile Pro Asp Glu Ala Asp Phe 

    370                 375                 380                 





Leu Leu Gly Met Ala Thr Val Asn Asn Cys Val Ser Tyr Arg Asn Pro 

385                 390                 395                 400 





Ala Glu Gly Thr Trp Tyr Ile Gln Ser Leu Cys Gln Ser Leu Arg Glu 

                405                 410                 415     





Arg Cys Pro Arg Gly Asp Asp Ile Leu Thr Ile Leu Thr Glu Val Asn 

            420                 425                 430         





Tyr Glu Val Ser Asn Lys Asp Asp Lys Lys Asn Met Gly Lys Gln Met 

        435                 440                 445             





Pro Gln Pro Thr Phe Thr Leu Arg Lys Lys Leu Val Phe Pro Ser Asp 

    450                 455                 460                 





<210>  146

<211>  538

<212>  PRT

<213>  Homo sapiens



<400>  146



Met Glu Gly Gly Arg Arg Ala Arg Val Val Ile Glu Ser Lys Arg Asn 

1               5                   10                  15      





Phe Phe Leu Gly Ala Phe Pro Thr Pro Phe Pro Ala Glu His Val Glu 

            20                  25                  30          





Leu Gly Arg Leu Gly Asp Ser Glu Thr Ala Met Val Pro Gly Lys Gly 

        35                  40                  45              





Gly Ala Asp Tyr Ile Leu Leu Pro Phe Lys Lys Met Asp Phe Ser Arg 

    50                  55                  60                  





Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser Glu Asp Leu Ala Ser 

65                  70                  75                  80  





Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln Arg Lys Gln Glu Pro 

                85                  90                  95      





Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu Gln Glu Lys Arg Met 

            100                 105                 110         





Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu Leu Leu Phe Arg Ile 

        115                 120                 125             





Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn Thr Arg Lys Glu Glu 

    130                 135                 140                 





Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala Gln Ile Ser Ala Tyr 

145                 150                 155                 160 





Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val Ser Arg Ser Glu Leu 

                165                 170                 175     





Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile Ser Lys Cys Lys Leu 

            180                 185                 190         





Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile Glu Met Glu Lys Arg 

        195                 200                 205             





Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu Lys Arg Val Cys Ala 

    210                 215                 220                 





Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn Asp Tyr Glu Glu Phe 

225                 230                 235                 240 





Ser Lys Glu Arg Ser Ser Ser Leu Glu Gly Ser Pro Asp Glu Phe Ser 

                245                 250                 255     





Asn Gly Glu Glu Leu Cys Gly Val Met Thr Ile Ser Asp Ser Pro Arg 

            260                 265                 270         





Glu Gln Asp Ser Glu Ser Gln Thr Leu Asp Lys Val Tyr Gln Met Lys 

        275                 280                 285             





Ser Lys Pro Arg Gly Tyr Cys Leu Ile Ile Asn Asn His Asn Phe Ala 

    290                 295                 300                 





Lys Ala Arg Glu Lys Val Pro Lys Leu His Ser Ile Arg Asp Arg Asn 

305                 310                 315                 320 





Gly Thr His Leu Asp Ala Gly Ala Leu Thr Thr Thr Phe Glu Glu Leu 

                325                 330                 335     





His Phe Glu Ile Lys Pro His Asp Asp Cys Thr Val Glu Gln Ile Tyr 

            340                 345                 350         





Glu Ile Leu Lys Ile Tyr Gln Leu Met Asp His Ser Asn Met Asp Cys 

        355                 360                 365             





Phe Ile Cys Cys Ile Leu Ser His Gly Asp Lys Gly Ile Ile Tyr Gly 

    370                 375                 380                 





Thr Asp Gly Gln Glu Ala Pro Ile Tyr Glu Leu Thr Ser Gln Phe Thr 

385                 390                 395                 400 





Gly Leu Lys Cys Pro Ser Leu Ala Gly Lys Pro Lys Val Phe Phe Ile 

                405                 410                 415     





Gln Ala Cys Gln Gly Asp Asn Tyr Gln Lys Gly Ile Pro Val Glu Thr 

            420                 425                 430         





Asp Ser Glu Glu Gln Pro Tyr Leu Glu Met Asp Leu Ser Ser Pro Gln 

        435                 440                 445             





Thr Arg Tyr Ile Pro Asp Glu Ala Asp Phe Leu Leu Gly Met Ala Thr 

    450                 455                 460                 





Val Asn Asn Cys Val Ser Tyr Arg Asn Pro Ala Glu Gly Thr Trp Tyr 

465                 470                 475                 480 





Ile Gln Ser Leu Cys Gln Ser Leu Arg Glu Arg Cys Pro Arg Gly Asp 

                485                 490                 495     





Asp Ile Leu Thr Ile Leu Thr Glu Val Asn Tyr Glu Val Ser Asn Lys 

            500                 505                 510         





Asp Asp Lys Lys Asn Met Gly Lys Gln Met Pro Gln Pro Thr Phe Thr 

        515                 520                 525             





Leu Arg Lys Lys Leu Val Phe Pro Ser Asp 

    530                 535             





<210>  147

<211>  496

<212>  PRT

<213>  Homo sapiens



<400>  147



Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 

1               5                   10                  15      





Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 

            20                  25                  30          





Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 

        35                  40                  45              





Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 

    50                  55                  60                  





Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn 

65                  70                  75                  80  





Thr Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala 

                85                  90                  95      





Gln Ile Ser Ala Tyr Arg Phe His Phe Cys Arg Met Ser Trp Ala Glu 

            100                 105                 110         





Ala Asn Ser Gln Cys Gln Thr Gln Ser Val Pro Phe Trp Arg Arg Val 

        115                 120                 125             





Asp His Leu Leu Ile Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 

    130                 135                 140                 





Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 

145                 150                 155                 160 





Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 

                165                 170                 175     





Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 

            180                 185                 190         





Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 

        195                 200                 205             





Asp Tyr Glu Glu Phe Ser Lys Gly Glu Glu Leu Cys Gly Val Met Thr 

    210                 215                 220                 





Ile Ser Asp Ser Pro Arg Glu Gln Asp Ser Glu Ser Gln Thr Leu Asp 

225                 230                 235                 240 





Lys Val Tyr Gln Met Lys Ser Lys Pro Arg Gly Tyr Cys Leu Ile Ile 

                245                 250                 255     





Asn Asn His Asn Phe Ala Lys Ala Arg Glu Lys Val Pro Lys Leu His 

            260                 265                 270         





Ser Ile Arg Asp Arg Asn Gly Thr His Leu Asp Ala Gly Ala Leu Thr 

        275                 280                 285             





Thr Thr Phe Glu Glu Leu His Phe Glu Ile Lys Pro His Asp Asp Cys 

    290                 295                 300                 





Thr Val Glu Gln Ile Tyr Glu Ile Leu Lys Ile Tyr Gln Leu Met Asp 

305                 310                 315                 320 





His Ser Asn Met Asp Cys Phe Ile Cys Cys Ile Leu Ser His Gly Asp 

                325                 330                 335     





Lys Gly Ile Ile Tyr Gly Thr Asp Gly Gln Glu Ala Pro Ile Tyr Glu 

            340                 345                 350         





Leu Thr Ser Gln Phe Thr Gly Leu Lys Cys Pro Ser Leu Ala Gly Lys 

        355                 360                 365             





Pro Lys Val Phe Phe Ile Gln Ala Cys Gln Gly Asp Asn Tyr Gln Lys 

    370                 375                 380                 





Gly Ile Pro Val Glu Thr Asp Ser Glu Glu Gln Pro Tyr Leu Glu Met 

385                 390                 395                 400 





Asp Leu Ser Ser Pro Gln Thr Arg Tyr Ile Pro Asp Glu Ala Asp Phe 

                405                 410                 415     





Leu Leu Gly Met Ala Thr Val Asn Asn Cys Val Ser Tyr Arg Asn Pro 

            420                 425                 430         





Ala Glu Gly Thr Trp Tyr Ile Gln Ser Leu Cys Gln Ser Leu Arg Glu 

        435                 440                 445             





Arg Cys Pro Arg Gly Asp Asp Ile Leu Thr Ile Leu Thr Glu Val Asn 

    450                 455                 460                 





Tyr Glu Val Ser Asn Lys Asp Asp Lys Lys Asn Met Gly Lys Gln Met 

465                 470                 475                 480 





Pro Gln Pro Thr Phe Thr Leu Arg Lys Lys Leu Val Phe Pro Ser Asp 

                485                 490                 495     





<210>  148

<211>  479

<212>  PRT

<213>  Homo sapiens



<400>  148



Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 

1               5                   10                  15      





Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 

            20                  25                  30          





Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 

        35                  40                  45              





Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 

    50                  55                  60                  





Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn 

65                  70                  75                  80  





Thr Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala 

                85                  90                  95      





Gln Ile Ser Ala Tyr Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 

            100                 105                 110         





Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 

        115                 120                 125             





Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 

    130                 135                 140                 





Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 

145                 150                 155                 160 





Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 

                165                 170                 175     





Asp Tyr Glu Glu Phe Ser Lys Glu Arg Ser Ser Ser Leu Glu Gly Ser 

            180                 185                 190         





Pro Asp Glu Phe Ser Asn Gly Glu Glu Leu Cys Gly Val Met Thr Ile 

        195                 200                 205             





Ser Asp Ser Pro Arg Glu Gln Asp Ser Glu Ser Gln Thr Leu Asp Lys 

    210                 215                 220                 





Val Tyr Gln Met Lys Ser Lys Pro Arg Gly Tyr Cys Leu Ile Ile Asn 

225                 230                 235                 240 





Asn His Asn Phe Ala Lys Ala Arg Glu Lys Val Pro Lys Leu His Ser 

                245                 250                 255     





Ile Arg Asp Arg Asn Gly Thr His Leu Asp Ala Gly Ala Leu Thr Thr 

            260                 265                 270         





Thr Phe Glu Glu Leu His Phe Glu Ile Lys Pro His Asp Asp Cys Thr 

        275                 280                 285             





Val Glu Gln Ile Tyr Glu Ile Leu Lys Ile Tyr Gln Leu Met Asp His 

    290                 295                 300                 





Ser Asn Met Asp Cys Phe Ile Cys Cys Ile Leu Ser His Gly Asp Lys 

305                 310                 315                 320 





Gly Ile Ile Tyr Gly Thr Asp Gly Gln Glu Ala Pro Ile Tyr Glu Leu 

                325                 330                 335     





Thr Ser Gln Phe Thr Gly Leu Lys Cys Pro Ser Leu Ala Gly Lys Pro 

            340                 345                 350         





Lys Val Phe Phe Ile Gln Ala Cys Gln Gly Asp Asn Tyr Gln Lys Gly 

        355                 360                 365             





Ile Pro Val Glu Thr Asp Ser Glu Glu Gln Pro Tyr Leu Glu Met Asp 

    370                 375                 380                 





Leu Ser Ser Pro Gln Thr Arg Tyr Ile Pro Asp Glu Ala Asp Phe Leu 

385                 390                 395                 400 





Leu Gly Met Ala Thr Val Asn Asn Cys Val Ser Tyr Arg Asn Pro Ala 

                405                 410                 415     





Glu Gly Thr Trp Tyr Ile Gln Ser Leu Cys Gln Ser Leu Arg Glu Arg 

            420                 425                 430         





Cys Pro Arg Gly Asp Asp Ile Leu Thr Ile Leu Thr Glu Val Asn Tyr 

        435                 440                 445             





Glu Val Ser Asn Lys Asp Asp Lys Lys Asn Met Gly Lys Gln Met Pro 

    450                 455                 460                 





Gln Pro Thr Phe Thr Leu Arg Lys Lys Leu Val Phe Pro Ser Asp 

465                 470                 475                 





<210>  149

<211>  464

<212>  PRT

<213>  Homo sapiens



<400>  149



Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 

1               5                   10                  15      





Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 

            20                  25                  30          





Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 

        35                  40                  45              





Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 

    50                  55                  60                  





Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn 

65                  70                  75                  80  





Thr Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala 

                85                  90                  95      





Gln Ile Ser Ala Tyr Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 

            100                 105                 110         





Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 

        115                 120                 125             





Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 

    130                 135                 140                 





Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 

145                 150                 155                 160 





Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 

                165                 170                 175     





Asp Tyr Glu Glu Phe Ser Lys Gly Glu Glu Leu Cys Gly Val Met Thr 

            180                 185                 190         





Ile Ser Asp Ser Pro Arg Glu Gln Asp Ser Glu Ser Gln Thr Leu Asp 

        195                 200                 205             





Lys Val Tyr Gln Met Lys Ser Lys Pro Arg Gly Tyr Cys Leu Ile Ile 

    210                 215                 220                 





Asn Asn His Asn Phe Ala Lys Ala Arg Glu Lys Val Pro Lys Leu His 

225                 230                 235                 240 





Ser Ile Arg Asp Arg Asn Gly Thr His Leu Asp Ala Gly Ala Leu Thr 

                245                 250                 255     





Thr Thr Phe Glu Glu Leu His Phe Glu Ile Lys Pro His Asp Asp Cys 

            260                 265                 270         





Thr Val Glu Gln Ile Tyr Glu Ile Leu Lys Ile Tyr Gln Leu Met Asp 

        275                 280                 285             





His Ser Asn Met Asp Cys Phe Ile Cys Cys Ile Leu Ser His Gly Asp 

    290                 295                 300                 





Lys Gly Ile Ile Tyr Gly Thr Asp Gly Gln Glu Ala Pro Ile Tyr Glu 

305                 310                 315                 320 





Leu Thr Ser Gln Phe Thr Gly Leu Lys Cys Pro Ser Leu Ala Gly Lys 

                325                 330                 335     





Pro Lys Val Phe Phe Ile Gln Ala Cys Gln Gly Asp Asn Tyr Gln Lys 

            340                 345                 350         





Gly Ile Pro Val Glu Thr Asp Ser Glu Glu Gln Pro Tyr Leu Glu Met 

        355                 360                 365             





Asp Leu Ser Ser Pro Gln Thr Arg Tyr Ile Pro Asp Glu Ala Asp Phe 

    370                 375                 380                 





Leu Leu Gly Met Ala Thr Val Asn Asn Cys Val Ser Tyr Arg Asn Pro 

385                 390                 395                 400 





Ala Glu Gly Thr Trp Tyr Ile Gln Ser Leu Cys Gln Ser Leu Arg Glu 

                405                 410                 415     





Arg Cys Pro Arg Gly Asp Asp Ile Leu Thr Ile Leu Thr Glu Val Asn 

            420                 425                 430         





Tyr Glu Val Ser Asn Lys Asp Asp Lys Lys Asn Met Gly Lys Gln Met 

        435                 440                 445             





Pro Gln Pro Thr Phe Thr Leu Arg Lys Lys Leu Val Phe Pro Ser Asp 

    450                 455                 460                 





<210>  150

<211>  235

<212>  PRT

<213>  Homo sapiens



<400>  150



Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 

1               5                   10                  15      





Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 

            20                  25                  30          





Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 

        35                  40                  45              





Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 

    50                  55                  60                  





Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn 

65                  70                  75                  80  





Thr Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala 

                85                  90                  95      





Gln Ile Ser Ala Tyr Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 

            100                 105                 110         





Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 

        115                 120                 125             





Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 

    130                 135                 140                 





Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 

145                 150                 155                 160 





Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 

                165                 170                 175     





Asp Tyr Glu Glu Phe Ser Lys Glu Arg Ser Ser Ser Leu Glu Gly Ser 

            180                 185                 190         





Pro Asp Glu Phe Ser Asn Asp Phe Gly Gln Ser Leu Pro Asn Glu Lys 

        195                 200                 205             





Gln Thr Ser Gly Ile Leu Ser Asp His Gln Gln Ser Gln Phe Cys Lys 

    210                 215                 220                 





Ser Thr Gly Glu Ser Ala Gln Thr Ser Gln His 

225                 230                 235 





<210>  151

<211>  257

<212>  PRT

<213>  Homo sapiens



<400>  151



Met Ala Gln Arg Met Thr Thr Gln Leu Leu Leu Leu Leu Val Trp Val 

1               5                   10                  15      





Ala Val Val Gly Glu Ala Gln Thr Arg Ile Ala Trp Ala Arg Thr Glu 

            20                  25                  30          





Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Glu Lys Pro Gly 

        35                  40                  45              





Pro Glu Asp Lys Leu His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala 

    50                  55                  60                  





Cys Cys Ser Thr Asn Thr Ser Gln Glu Ala His Lys Asp Val Ser Tyr 

65                  70                  75                  80  





Leu Tyr Arg Phe Asn Trp Asn His Cys Gly Glu Met Ala Pro Ala Cys 

                85                  90                  95      





Lys Arg His Phe Ile Gln Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn 

            100                 105                 110         





Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg 

        115                 120                 125             





Val Leu Asn Val Pro Leu Cys Lys Glu Asp Cys Glu Gln Trp Trp Glu 

    130                 135                 140                 





Asp Cys Arg Thr Ser Tyr Thr Cys Lys Ser Asn Trp His Lys Gly Trp 

145                 150                 155                 160 





Asn Trp Thr Ser Gly Phe Asn Lys Cys Ala Val Gly Ala Ala Cys Gln 

                165                 170                 175     





Pro Phe His Phe Tyr Phe Pro Thr Pro Thr Val Leu Cys Asn Glu Ile 

            180                 185                 190         





Trp Thr His Ser Tyr Lys Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg 

        195                 200                 205             





Cys Ile Gln Met Trp Phe Asp Pro Ala Gln Gly Asn Pro Asn Glu Glu 

    210                 215                 220                 





Val Ala Arg Phe Tyr Ala Ala Ala Met Ser Gly Ala Gly Pro Trp Ala 

225                 230                 235                 240 





Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met Leu Leu Trp Leu Leu 

                245                 250                 255     





Ser 

    





<210>  152

<211>  257

<212>  PRT

<213>  Homo sapiens



<400>  152



Met Ala Gln Arg Met Thr Thr Gln Leu Leu Leu Leu Leu Val Trp Val 

1               5                   10                  15      





Ala Val Val Gly Glu Ala Gln Thr Arg Ile Ala Trp Ala Arg Thr Glu 

            20                  25                  30          





Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Glu Lys Pro Gly 

        35                  40                  45              





Pro Glu Asp Lys Leu His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala 

    50                  55                  60                  





Cys Cys Ser Thr Asn Thr Ser Gln Glu Ala His Lys Asp Val Ser Tyr 

65                  70                  75                  80  





Leu Tyr Arg Phe Asn Trp Asn His Cys Gly Glu Met Ala Pro Ala Cys 

                85                  90                  95      





Lys Arg His Phe Ile Gln Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn 

            100                 105                 110         





Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg 

        115                 120                 125             





Val Leu Asn Val Pro Leu Cys Lys Glu Asp Cys Glu Gln Trp Trp Glu 

    130                 135                 140                 





Asp Cys Arg Thr Ser Tyr Thr Cys Lys Ser Asn Trp His Lys Gly Trp 

145                 150                 155                 160 





Asn Trp Thr Ser Gly Phe Asn Lys Cys Ala Val Gly Ala Ala Cys Gln 

                165                 170                 175     





Pro Phe His Phe Tyr Phe Pro Thr Pro Thr Val Leu Cys Asn Glu Ile 

            180                 185                 190         





Trp Thr His Ser Tyr Lys Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg 

        195                 200                 205             





Cys Ile Gln Met Trp Phe Asp Pro Ala Gln Gly Asn Pro Asn Glu Glu 

    210                 215                 220                 





Val Ala Arg Phe Tyr Ala Ala Ala Met Ser Gly Ala Gly Pro Trp Ala 

225                 230                 235                 240 





Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met Leu Leu Trp Leu Leu 

                245                 250                 255     





Ser 

    





<210>  153

<211>  257

<212>  PRT

<213>  Homo sapiens



<400>  153



Met Ala Gln Arg Met Thr Thr Gln Leu Leu Leu Leu Leu Val Trp Val 

1               5                   10                  15      





Ala Val Val Gly Glu Ala Gln Thr Arg Ile Ala Trp Ala Arg Thr Glu 

            20                  25                  30          





Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Glu Lys Pro Gly 

        35                  40                  45              





Pro Glu Asp Lys Leu His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala 

    50                  55                  60                  





Cys Cys Ser Thr Asn Thr Ser Gln Glu Ala His Lys Asp Val Ser Tyr 

65                  70                  75                  80  





Leu Tyr Arg Phe Asn Trp Asn His Cys Gly Glu Met Ala Pro Ala Cys 

                85                  90                  95      





Lys Arg His Phe Ile Gln Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn 

            100                 105                 110         





Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg 

        115                 120                 125             





Val Leu Asn Val Pro Leu Cys Lys Glu Asp Cys Glu Gln Trp Trp Glu 

    130                 135                 140                 





Asp Cys Arg Thr Ser Tyr Thr Cys Lys Ser Asn Trp His Lys Gly Trp 

145                 150                 155                 160 





Asn Trp Thr Ser Gly Phe Asn Lys Cys Ala Val Gly Ala Ala Cys Gln 

                165                 170                 175     





Pro Phe His Phe Tyr Phe Pro Thr Pro Thr Val Leu Cys Asn Glu Ile 

            180                 185                 190         





Trp Thr His Ser Tyr Lys Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg 

        195                 200                 205             





Cys Ile Gln Met Trp Phe Asp Pro Ala Gln Gly Asn Pro Asn Glu Glu 

    210                 215                 220                 





Val Ala Arg Phe Tyr Ala Ala Ala Met Ser Gly Ala Gly Pro Trp Ala 

225                 230                 235                 240 





Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met Leu Leu Trp Leu Leu 

                245                 250                 255     





Ser 

    





<210>  154

<211>  257

<212>  PRT

<213>  Homo sapiens



<400>  154



Met Ala Gln Arg Met Thr Thr Gln Leu Leu Leu Leu Leu Val Trp Val 

1               5                   10                  15      





Ala Val Val Gly Glu Ala Gln Thr Arg Ile Ala Trp Ala Arg Thr Glu 

            20                  25                  30          





Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Glu Lys Pro Gly 

        35                  40                  45              





Pro Glu Asp Lys Leu His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala 

    50                  55                  60                  





Cys Cys Ser Thr Asn Thr Ser Gln Glu Ala His Lys Asp Val Ser Tyr 

65                  70                  75                  80  





Leu Tyr Arg Phe Asn Trp Asn His Cys Gly Glu Met Ala Pro Ala Cys 

                85                  90                  95      





Lys Arg His Phe Ile Gln Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn 

            100                 105                 110         





Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg 

        115                 120                 125             





Val Leu Asn Val Pro Leu Cys Lys Glu Asp Cys Glu Gln Trp Trp Glu 

    130                 135                 140                 





Asp Cys Arg Thr Ser Tyr Thr Cys Lys Ser Asn Trp His Lys Gly Trp 

145                 150                 155                 160 





Asn Trp Thr Ser Gly Phe Asn Lys Cys Ala Val Gly Ala Ala Cys Gln 

                165                 170                 175     





Pro Phe His Phe Tyr Phe Pro Thr Pro Thr Val Leu Cys Asn Glu Ile 

            180                 185                 190         





Trp Thr His Ser Tyr Lys Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg 

        195                 200                 205             





Cys Ile Gln Met Trp Phe Asp Pro Ala Gln Gly Asn Pro Asn Glu Glu 

    210                 215                 220                 





Val Ala Arg Phe Tyr Ala Ala Ala Met Ser Gly Ala Gly Pro Trp Ala 

225                 230                 235                 240 





Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met Leu Leu Trp Leu Leu 

                245                 250                 255     





Ser 

    





<210>  155

<211>  459

<212>  PRT

<213>  Homo sapiens



<400>  155



Met Ala Pro Leu Cys Pro Ser Pro Trp Leu Pro Leu Leu Ile Pro Ala 

1               5                   10                  15      





Pro Ala Pro Gly Leu Thr Val Gln Leu Leu Leu Ser Leu Leu Leu Leu 

            20                  25                  30          





Val Pro Val His Pro Gln Arg Leu Pro Arg Met Gln Glu Asp Ser Pro 

        35                  40                  45              





Leu Gly Gly Gly Ser Ser Gly Glu Asp Asp Pro Leu Gly Glu Glu Asp 

    50                  55                  60                  





Leu Pro Ser Glu Glu Asp Ser Pro Arg Glu Glu Asp Pro Pro Gly Glu 

65                  70                  75                  80  





Glu Asp Leu Pro Gly Glu Glu Asp Leu Pro Gly Glu Glu Asp Leu Pro 

                85                  90                  95      





Glu Val Lys Pro Lys Ser Glu Glu Glu Gly Ser Leu Lys Leu Glu Asp 

            100                 105                 110         





Leu Pro Thr Val Glu Ala Pro Gly Asp Pro Gln Glu Pro Gln Asn Asn 

        115                 120                 125             





Ala His Arg Asp Lys Glu Gly Asp Asp Gln Ser His Trp Arg Tyr Gly 

    130                 135                 140                 





Gly Asp Pro Pro Trp Pro Arg Val Ser Pro Ala Cys Ala Gly Arg Phe 

145                 150                 155                 160 





Gln Ser Pro Val Asp Ile Arg Pro Gln Leu Ala Ala Phe Cys Pro Ala 

                165                 170                 175     





Leu Arg Pro Leu Glu Leu Leu Gly Phe Gln Leu Pro Pro Leu Pro Glu 

            180                 185                 190         





Leu Arg Leu Arg Asn Asn Gly His Ser Val Gln Leu Thr Leu Pro Pro 

        195                 200                 205             





Gly Leu Glu Met Ala Leu Gly Pro Gly Arg Glu Tyr Arg Ala Leu Gln 

    210                 215                 220                 





Leu His Leu His Trp Gly Ala Ala Gly Arg Pro Gly Ser Glu His Thr 

225                 230                 235                 240 





Val Glu Gly His Arg Phe Pro Ala Glu Ile His Val Val His Leu Ser 

                245                 250                 255     





Thr Ala Phe Ala Arg Val Asp Glu Ala Leu Gly Arg Pro Gly Gly Leu 

            260                 265                 270         





Ala Val Leu Ala Ala Phe Leu Glu Glu Gly Pro Glu Glu Asn Ser Ala 

        275                 280                 285             





Tyr Glu Gln Leu Leu Ser Arg Leu Glu Glu Ile Ala Glu Glu Gly Ser 

    290                 295                 300                 





Glu Thr Gln Val Pro Gly Leu Asp Ile Ser Ala Leu Leu Pro Ser Asp 

305                 310                 315                 320 





Phe Ser Arg Tyr Phe Gln Tyr Glu Gly Ser Leu Thr Thr Pro Pro Cys 

                325                 330                 335     





Ala Gln Gly Val Ile Trp Thr Val Phe Asn Gln Thr Val Met Leu Ser 

            340                 345                 350         





Ala Lys Gln Leu His Thr Leu Ser Asp Thr Leu Trp Gly Pro Gly Asp 

        355                 360                 365             





Ser Arg Leu Gln Leu Asn Phe Arg Ala Thr Gln Pro Leu Asn Gly Arg 

    370                 375                 380                 





Val Ile Glu Ala Ser Phe Pro Ala Gly Val Asp Ser Ser Pro Arg Ala 

385                 390                 395                 400 





Ala Glu Pro Val Gln Leu Asn Ser Cys Leu Ala Ala Gly Asp Ile Leu 

                405                 410                 415     





Ala Leu Val Phe Gly Leu Leu Phe Ala Val Thr Ser Val Ala Phe Leu 

            420                 425                 430         





Val Gln Met Arg Arg Gln His Arg Arg Gly Thr Lys Gly Gly Val Ser 

        435                 440                 445             





Tyr Arg Pro Ala Glu Val Ala Glu Thr Gly Ala 

    450                 455                 





<210>  156

<211>  557

<212>  PRT

<213>  Homo sapiens



<400>  156



Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 

1               5                   10                  15      





Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 

            20                  25                  30          





Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 

        35                  40                  45              





Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 

    50                  55                  60                  





Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 

65                  70                  75                  80  





Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 

                85                  90                  95      





Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 

            100                 105                 110         





Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 

        115                 120                 125             





Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 

    130                 135                 140                 





Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 

145                 150                 155                 160 





Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 

                165                 170                 175     





Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 

            180                 185                 190         





Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 

        195                 200                 205             





Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 

    210                 215                 220                 





Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 

225                 230                 235                 240 





Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 

                245                 250                 255     





Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 

            260                 265                 270         





Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 

        275                 280                 285             





Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 

    290                 295                 300                 





Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg 

305                 310                 315                 320 





Arg Lys Arg Lys Arg Met Thr Asp Pro Thr Arg Arg Phe Phe Lys Val 

                325                 330                 335     





Thr Pro Pro Pro Gly Ser Gly Pro Gln Asn Gln Tyr Gly Asn Val Leu 

            340                 345                 350         





Ser Leu Pro Thr Pro Thr Ser Gly Leu Gly Arg Ala Gln Arg Trp Ala 

        355                 360                 365             





Ala Gly Leu Gly Gly Thr Ala Pro Ser Tyr Gly Asn Pro Ser Ser Asp 

    370                 375                 380                 





Val Gln Ala Asp Gly Ala Leu Gly Ser Arg Ser Pro Pro Gly Val Gly 

385                 390                 395                 400 





Pro Glu Glu Glu Glu Gly Glu Gly Tyr Glu Glu Pro Asp Ser Glu Glu 

                405                 410                 415     





Asp Ser Glu Phe Tyr Glu Asn Asp Ser Asn Leu Gly Gln Asp Gln Leu 

            420                 425                 430         





Ser Gln Asp Gly Ser Gly Tyr Glu Asn Pro Glu Asp Glu Pro Leu Gly 

        435                 440                 445             





Pro Glu Asp Glu Asp Ser Phe Ser Asn Ala Glu Ser Tyr Glu Asn Glu 

    450                 455                 460                 





Asp Glu Glu Leu Thr Gln Pro Val Ala Arg Thr Met Asp Phe Leu Ser 

465                 470                 475                 480 





Pro His Gly Ser Ala Trp Asp Pro Ser Arg Glu Ala Thr Ser Leu Ala 

                485                 490                 495     





Gly Ser Gln Ser Tyr Glu Asp Met Arg Gly Ile Leu Tyr Ala Ala Pro 

            500                 505                 510         





Gln Leu Arg Ser Ile Arg Gly Gln Pro Gly Pro Asn His Glu Glu Asp 

        515                 520                 525             





Ala Asp Ser Tyr Glu Asn Met Asp Asn Pro Asp Gly Pro Asp Pro Ala 

    530                 535                 540                 





Trp Gly Gly Gly Gly Arg Met Gly Thr Trp Ser Thr Arg 

545                 550                 555         





<210>  157

<211>  556

<212>  PRT

<213>  Homo sapiens



<400>  157



Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 

1               5                   10                  15      





Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 

            20                  25                  30          





Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 

        35                  40                  45              





Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 

    50                  55                  60                  





Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 

65                  70                  75                  80  





Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 

                85                  90                  95      





Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 

            100                 105                 110         





Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 

        115                 120                 125             





Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 

    130                 135                 140                 





Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 

145                 150                 155                 160 





Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 

                165                 170                 175     





Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 

            180                 185                 190         





Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 

        195                 200                 205             





Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 

    210                 215                 220                 





Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 

225                 230                 235                 240 





Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 

                245                 250                 255     





Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 

            260                 265                 270         





Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 

        275                 280                 285             





Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 

    290                 295                 300                 





Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg 

305                 310                 315                 320 





Arg Lys Arg Lys Arg Met Thr Asp Pro Thr Arg Arg Phe Phe Lys Val 

                325                 330                 335     





Thr Pro Pro Pro Gly Ser Gly Pro Gln Asn Gln Tyr Gly Asn Val Leu 

            340                 345                 350         





Ser Leu Pro Thr Pro Thr Ser Gly Leu Gly Arg Ala Gln Arg Trp Ala 

        355                 360                 365             





Ala Gly Leu Gly Gly Thr Ala Pro Ser Tyr Gly Asn Pro Ser Ser Asp 

    370                 375                 380                 





Val Gln Ala Asp Gly Ala Leu Gly Ser Arg Ser Pro Pro Gly Val Gly 

385                 390                 395                 400 





Pro Glu Glu Glu Glu Gly Glu Gly Tyr Glu Glu Pro Asp Ser Glu Glu 

                405                 410                 415     





Asp Ser Glu Phe Tyr Glu Asn Asp Ser Asn Leu Gly Gln Asp Gln Leu 

            420                 425                 430         





Ser Gln Asp Gly Ser Gly Tyr Glu Asn Pro Glu Asp Glu Pro Leu Gly 

        435                 440                 445             





Pro Glu Asp Glu Asp Ser Phe Ser Asn Ala Glu Ser Tyr Glu Asn Glu 

    450                 455                 460                 





Asp Glu Glu Leu Thr Gln Pro Val Ala Arg Thr Met Asp Phe Leu Ser 

465                 470                 475                 480 





Pro His Gly Ser Ala Trp Asp Pro Ser Arg Glu Ala Thr Ser Leu Gly 

                485                 490                 495     





Ser Gln Ser Tyr Glu Asp Met Arg Gly Ile Leu Tyr Ala Ala Pro Gln 

            500                 505                 510         





Leu Arg Ser Ile Arg Gly Gln Pro Gly Pro Asn His Glu Glu Asp Ala 

        515                 520                 525             





Asp Ser Tyr Glu Asn Met Asp Asn Pro Asp Gly Pro Asp Pro Ala Trp 

    530                 535                 540                 





Gly Gly Gly Gly Arg Met Gly Thr Trp Ser Thr Arg 

545                 550                 555     





<210>  158

<211>  297

<212>  PRT

<213>  Homo sapiens



<400>  158



Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro 

1               5                   10                  15      





Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg 

            20                  25                  30          





Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu 

        35                  40                  45              





Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile 

    50                  55                  60                  





Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile 

65                  70                  75                  80  





Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile 

                85                  90                  95      





Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu 

            100                 105                 110         





Val Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile 

        115                 120                 125             





Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser 

    130                 135                 140                 





His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro 

145                 150                 155                 160 





Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn 

                165                 170                 175     





Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly 

            180                 185                 190         





Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile 

        195                 200                 205             





Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys 

    210                 215                 220                 





Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile 

225                 230                 235                 240 





Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro 

                245                 250                 255     





Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu 

            260                 265                 270         





Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser 

        275                 280                 285             





Ser Pro Ile Glu Asn Asp Ser Ser Pro 

    290                 295         





<210>  159

<211>  297

<212>  PRT

<213>  Homo sapiens



<400>  159



Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro 

1               5                   10                  15      





Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg 

            20                  25                  30          





Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu 

        35                  40                  45              





Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile 

    50                  55                  60                  





Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile 

65                  70                  75                  80  





Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile 

                85                  90                  95      





Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu 

            100                 105                 110         





Val Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile 

        115                 120                 125             





Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser 

    130                 135                 140                 





His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro 

145                 150                 155                 160 





Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn 

                165                 170                 175     





Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly 

            180                 185                 190         





Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile 

        195                 200                 205             





Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys 

    210                 215                 220                 





Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile 

225                 230                 235                 240 





Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro 

                245                 250                 255     





Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu 

            260                 265                 270         





Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser 

        275                 280                 285             





Ser Pro Ile Glu Asn Asp Ser Ser Pro 

    290                 295         





<210>  160

<211>  759

<212>  PRT

<213>  Homo sapiens



<400>  160



Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu 

1               5                   10                  15      





Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu 

            20                  25                  30          





Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala 

        35                  40                  45              





Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr 

    50                  55                  60                  





Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr 

65                  70                  75                  80  





Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly 

                85                  90                  95      





Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn 

            100                 105                 110         





Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp 

        115                 120                 125             





Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His 

    130                 135                 140                 





Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr 

145                 150                 155                 160 





Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp 

                165                 170                 175     





Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser 

            180                 185                 190         





Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro 

        195                 200                 205             





Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala 

    210                 215                 220                 





Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His 

225                 230                 235                 240 





Thr Pro Lys Leu Glu Ile Lys Val Thr Pro Ser Asp Ala Ile Val Arg 

                245                 250                 255     





Glu Gly Asp Ser Val Thr Met Thr Cys Glu Val Ser Ser Ser Asn Pro 

            260                 265                 270         





Glu Tyr Thr Thr Val Ser Trp Leu Lys Asp Gly Thr Ser Leu Lys Lys 

        275                 280                 285             





Gln Asn Thr Phe Thr Leu Asn Leu Arg Glu Val Thr Lys Asp Gln Ser 

    290                 295                 300                 





Gly Lys Tyr Cys Cys Gln Val Ser Asn Asp Val Gly Pro Gly Arg Ser 

305                 310                 315                 320 





Glu Glu Val Phe Leu Gln Val Gln Tyr Pro Pro Lys Lys Val Thr Thr 

                325                 330                 335     





Val Ile Gln Asn Pro Met Pro Ile Arg Glu Gly Asp Thr Val Thr Leu 

            340                 345                 350         





Ser Cys Asn Tyr Asn Ser Ser Asn Pro Ser Val Thr Arg Tyr Glu Trp 

        355                 360                 365             





Lys Pro His Gly Ala Trp Glu Glu Pro Ser Leu Gly Val Leu Lys Ile 

    370                 375                 380                 





Gln Asn Val Gly Trp Asp Asn Thr Thr Ile Ala Cys Ala Ala Cys Asn 

385                 390                 395                 400 





Ser Trp Cys Ser Trp Ala Ser Pro Val Ala Leu Asn Val Gln Tyr Ala 

                405                 410                 415     





Pro Arg Asp Val Arg Val Arg Lys Ile Lys Pro Leu Ser Glu Ile His 

            420                 425                 430         





Ser Gly Asn Ser Val Ser Leu Gln Cys Asp Phe Ser Ser Ser His Pro 

        435                 440                 445             





Lys Glu Val Gln Phe Phe Trp Glu Lys Asn Gly Arg Leu Leu Gly Lys 

    450                 455                 460                 





Glu Ser Gln Leu Asn Phe Asp Ser Ile Ser Pro Glu Asp Ala Gly Ser 

465                 470                 475                 480 





Tyr Ser Cys Trp Val Asn Asn Ser Ile Gly Gln Thr Ala Ser Lys Ala 

                485                 490                 495     





Trp Thr Leu Glu Val Leu Tyr Ala Pro Arg Arg Leu Arg Val Ser Met 

            500                 505                 510         





Ser Pro Gly Asp Gln Val Met Glu Gly Lys Ser Ala Thr Leu Thr Cys 

        515                 520                 525             





Glu Ser Asp Ala Asn Pro Pro Val Ser His Tyr Thr Trp Phe Asp Trp 

    530                 535                 540                 





Asn Asn Gln Ser Leu Pro Tyr His Ser Gln Lys Leu Arg Leu Glu Pro 

545                 550                 555                 560 





Val Lys Val Gln His Ser Gly Ala Tyr Trp Cys Gln Gly Thr Asn Ser 

                565                 570                 575     





Val Gly Lys Gly Arg Ser Pro Leu Ser Thr Leu Thr Val Tyr Tyr Ser 

            580                 585                 590         





Pro Glu Thr Ile Gly Arg Arg Val Ala Val Gly Leu Gly Ser Cys Leu 

        595                 600                 605             





Ala Ile Leu Ile Leu Ala Ile Cys Gly Leu Lys Leu Gln Arg Arg Trp 

    610                 615                 620                 





Lys Arg Thr Gln Ser Gln Gln Gly Leu Gln Glu Asn Ser Ser Gly Gln 

625                 630                 635                 640 





Ser Phe Phe Val Arg Asn Lys Lys Val Arg Arg Ala Pro Leu Ser Glu 

                645                 650                 655     





Gly Pro His Ser Leu Gly Cys Tyr Asn Pro Met Met Glu Asp Gly Ile 

            660                 665                 670         





Ser Tyr Thr Thr Leu Arg Phe Pro Glu Met Asn Ile Pro Arg Thr Gly 

        675                 680                 685             





Asp Ala Glu Ser Ser Glu Met Gln Arg Pro Pro Pro Asp Cys Asp Asp 

    690                 695                 700                 





Thr Val Thr Tyr Ser Ala Leu His Lys Arg Gln Val Gly Asp Tyr Glu 

705                 710                 715                 720 





Asn Val Ile Pro Asp Phe Pro Glu Asp Glu Gly Ile His Tyr Ser Glu 

                725                 730                 735     





Leu Ile Gln Phe Gly Val Gly Glu Arg Pro Gln Ala Gln Glu Asn Val 

            740                 745                 750         





Asp Tyr Val Ile Leu Lys His 

        755                 





<210>  161

<211>  751

<212>  PRT

<213>  Homo sapiens



<400>  161



Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu 

1               5                   10                  15      





Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu 

            20                  25                  30          





Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala 

        35                  40                  45              





Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr 

    50                  55                  60                  





Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr 

65                  70                  75                  80  





Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly 

                85                  90                  95      





Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn 

            100                 105                 110         





Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp 

        115                 120                 125             





Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His 

    130                 135                 140                 





Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr 

145                 150                 155                 160 





Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp 

                165                 170                 175     





Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser 

            180                 185                 190         





Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro 

        195                 200                 205             





Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala 

    210                 215                 220                 





Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His 

225                 230                 235                 240 





Thr Pro Lys Leu Glu Ile Lys Val Thr Pro Ser Asp Ala Ile Val Arg 

                245                 250                 255     





Glu Gly Asp Ser Val Thr Met Thr Cys Glu Val Ser Ser Ser Asn Pro 

            260                 265                 270         





Glu Tyr Thr Thr Val Ser Trp Leu Lys Asp Gly Thr Ser Leu Lys Lys 

        275                 280                 285             





Gln Asn Thr Phe Thr Leu Asn Leu Arg Glu Val Thr Lys Asp Gln Ser 

    290                 295                 300                 





Gly Lys Tyr Cys Cys Gln Val Ser Asn Asp Val Gly Pro Gly Arg Ser 

305                 310                 315                 320 





Glu Glu Val Phe Leu Gln Val Gln Tyr Ala Pro Glu Pro Ser Thr Val 

                325                 330                 335     





Gln Ile Leu His Ser Pro Ala Val Glu Gly Ser Gln Val Glu Phe Leu 

            340                 345                 350         





Cys Met Ser Leu Ala Asn Pro Leu Pro Thr Asn Tyr Thr Trp Tyr His 

        355                 360                 365             





Asn Gly Lys Glu Met Gln Gly Arg Thr Glu Glu Lys Val His Ile Pro 

    370                 375                 380                 





Lys Ile Leu Pro Trp His Ala Gly Thr Tyr Ser Cys Val Ala Glu Asn 

385                 390                 395                 400 





Ile Leu Gly Thr Gly Gln Arg Gly Pro Gly Ala Glu Leu Asp Val Gln 

                405                 410                 415     





Tyr Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met Pro Ile 

            420                 425                 430         





Arg Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser Ser Asn 

        435                 440                 445             





Pro Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp Glu Glu 

    450                 455                 460                 





Pro Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp Asn Thr 

465                 470                 475                 480 





Thr Ile Ala Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp Ala Ser Pro 

                485                 490                 495     





Val Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg Val Arg Lys 

            500                 505                 510         





Ile Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val Ser Leu Gln 

        515                 520                 525             





Cys Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe Phe Trp Glu 

    530                 535                 540                 





Lys Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn Phe Asp Ser 

545                 550                 555                 560 





Ile Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val Asn Asn Ser 

                565                 570                 575     





Ile Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val Leu Tyr Ala 

            580                 585                 590         





Pro Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln Val Met Glu 

        595                 600                 605             





Gly Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn Pro Pro Val 

    610                 615                 620                 





Ser His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu Pro Tyr His 

625                 630                 635                 640 





Ser Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His Ser Gly Ala 

                645                 650                 655     





Tyr Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg Ser Pro Leu 

            660                 665                 670         





Ser Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Ile Gly Arg Arg Val 

        675                 680                 685             





Ala Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile Cys 

    690                 695                 700                 





Gly Leu Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly 

705                 710                 715                 720 





Leu Gln Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys 

                725                 730                 735     





Arg Cys Arg Val Leu Arg Asp Ala Glu Thr Ser Pro Gly Leu Arg 

            740                 745                 750     





<210>  162

<211>  670

<212>  PRT

<213>  Homo sapiens



<400>  162



Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu 

1               5                   10                  15      





Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu 

            20                  25                  30          





Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala 

        35                  40                  45              





Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr 

    50                  55                  60                  





Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr 

65                  70                  75                  80  





Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly 

                85                  90                  95      





Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn 

            100                 105                 110         





Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp 

        115                 120                 125             





Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His 

    130                 135                 140                 





Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr 

145                 150                 155                 160 





Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp 

                165                 170                 175     





Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser 

            180                 185                 190         





Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro 

        195                 200                 205             





Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala 

    210                 215                 220                 





Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His 

225                 230                 235                 240 





Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met Pro Ile Arg 

                245                 250                 255     





Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser Ser Asn Pro 

            260                 265                 270         





Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp Glu Glu Pro 

        275                 280                 285             





Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp Asn Thr Thr 

    290                 295                 300                 





Ile Ala Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp Ala Ser Pro Val 

305                 310                 315                 320 





Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg Val Arg Lys Ile 

                325                 330                 335     





Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val Ser Leu Gln Cys 

            340                 345                 350         





Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe Phe Trp Glu Lys 

        355                 360                 365             





Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn Phe Asp Ser Ile 

    370                 375                 380                 





Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val Asn Asn Ser Ile 

385                 390                 395                 400 





Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val Leu Tyr Ala Pro 

                405                 410                 415     





Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln Val Met Glu Gly 

            420                 425                 430         





Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn Pro Pro Val Ser 

        435                 440                 445             





His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu Pro Tyr His Ser 

    450                 455                 460                 





Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His Ser Gly Ala Tyr 

465                 470                 475                 480 





Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg Ser Pro Leu Ser 

                485                 490                 495     





Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Ile Gly Arg Arg Val Ala 

            500                 505                 510         





Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile Cys Gly 

        515                 520                 525             





Leu Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly Leu 

    530                 535                 540                 





Gln Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys Val 

545                 550                 555                 560 





Arg Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr Asn 

                565                 570                 575     





Pro Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro Glu 

            580                 585                 590         





Met Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln Arg 

        595                 600                 605             





Pro Pro Pro Asp Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His Lys 

    610                 615                 620                 





Arg Gln Val Gly Asp Tyr Glu Asn Val Ile Pro Asp Phe Pro Glu Asp 

625                 630                 635                 640 





Glu Gly Ile His Tyr Ser Glu Leu Ile Gln Phe Gly Val Gly Glu Arg 

                645                 650                 655     





Pro Gln Ala Gln Glu Asn Val Asp Tyr Val Ile Leu Lys His 

            660                 665                 670 





<210>  163

<211>  847

<212>  PRT

<213>  Homo sapiens



<400>  163



Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu 

1               5                   10                  15      





Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu 

            20                  25                  30          





Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala 

        35                  40                  45              





Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr 

    50                  55                  60                  





Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr 

65                  70                  75                  80  





Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly 

                85                  90                  95      





Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn 

            100                 105                 110         





Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp 

        115                 120                 125             





Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His 

    130                 135                 140                 





Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr 

145                 150                 155                 160 





Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp 

                165                 170                 175     





Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser 

            180                 185                 190         





Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro 

        195                 200                 205             





Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala 

    210                 215                 220                 





Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His 

225                 230                 235                 240 





Thr Pro Lys Leu Glu Ile Lys Val Thr Pro Ser Asp Ala Ile Val Arg 

                245                 250                 255     





Glu Gly Asp Ser Val Thr Met Thr Cys Glu Val Ser Ser Ser Asn Pro 

            260                 265                 270         





Glu Tyr Thr Thr Val Ser Trp Leu Lys Asp Gly Thr Ser Leu Lys Lys 

        275                 280                 285             





Gln Asn Thr Phe Thr Leu Asn Leu Arg Glu Val Thr Lys Asp Gln Ser 

    290                 295                 300                 





Gly Lys Tyr Cys Cys Gln Val Ser Asn Asp Val Gly Pro Gly Arg Ser 

305                 310                 315                 320 





Glu Glu Val Phe Leu Gln Val Gln Tyr Ala Pro Glu Pro Ser Thr Val 

                325                 330                 335     





Gln Ile Leu His Ser Pro Ala Val Glu Gly Ser Gln Val Glu Phe Leu 

            340                 345                 350         





Cys Met Ser Leu Ala Asn Pro Leu Pro Thr Asn Tyr Thr Trp Tyr His 

        355                 360                 365             





Asn Gly Lys Glu Met Gln Gly Arg Thr Glu Glu Lys Val His Ile Pro 

    370                 375                 380                 





Lys Ile Leu Pro Trp His Ala Gly Thr Tyr Ser Cys Val Ala Glu Asn 

385                 390                 395                 400 





Ile Leu Gly Thr Gly Gln Arg Gly Pro Gly Ala Glu Leu Asp Val Gln 

                405                 410                 415     





Tyr Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met Pro Ile 

            420                 425                 430         





Arg Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser Ser Asn 

        435                 440                 445             





Pro Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp Glu Glu 

    450                 455                 460                 





Pro Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp Asn Thr 

465                 470                 475                 480 





Thr Ile Ala Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp Ala Ser Pro 

                485                 490                 495     





Val Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg Val Arg Lys 

            500                 505                 510         





Ile Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val Ser Leu Gln 

        515                 520                 525             





Cys Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe Phe Trp Glu 

    530                 535                 540                 





Lys Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn Phe Asp Ser 

545                 550                 555                 560 





Ile Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val Asn Asn Ser 

                565                 570                 575     





Ile Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val Leu Tyr Ala 

            580                 585                 590         





Pro Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln Val Met Glu 

        595                 600                 605             





Gly Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn Pro Pro Val 

    610                 615                 620                 





Ser His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu Pro Tyr His 

625                 630                 635                 640 





Ser Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His Ser Gly Ala 

                645                 650                 655     





Tyr Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg Ser Pro Leu 

            660                 665                 670         





Ser Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Ile Gly Arg Arg Val 

        675                 680                 685             





Ala Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile Cys 

    690                 695                 700                 





Gly Leu Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly 

705                 710                 715                 720 





Leu Gln Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys 

                725                 730                 735     





Val Arg Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr 

            740                 745                 750         





Asn Pro Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro 

        755                 760                 765             





Glu Met Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln 

    770                 775                 780                 





Arg Pro Pro Pro Asp Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His 

785                 790                 795                 800 





Lys Arg Gln Val Gly Asp Tyr Glu Asn Val Ile Pro Asp Phe Pro Glu 

                805                 810                 815     





Asp Glu Gly Ile His Tyr Ser Glu Leu Ile Gln Phe Gly Val Gly Glu 

            820                 825                 830         





Arg Pro Gln Ala Gln Glu Asn Val Asp Tyr Val Ile Leu Lys His 

        835                 840                 845         





<210>  164

<211>  847

<212>  PRT

<213>  Homo sapiens



<400>  164



Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu 

1               5                   10                  15      





Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu 

            20                  25                  30          





Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala 

        35                  40                  45              





Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr 

    50                  55                  60                  





Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr 

65                  70                  75                  80  





Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly 

                85                  90                  95      





Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn 

            100                 105                 110         





Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp 

        115                 120                 125             





Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His 

    130                 135                 140                 





Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr 

145                 150                 155                 160 





Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp 

                165                 170                 175     





Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser 

            180                 185                 190         





Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro 

        195                 200                 205             





Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala 

    210                 215                 220                 





Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His 

225                 230                 235                 240 





Thr Pro Lys Leu Glu Ile Lys Val Thr Pro Ser Asp Ala Ile Val Arg 

                245                 250                 255     





Glu Gly Asp Ser Val Thr Met Thr Cys Glu Val Ser Ser Ser Asn Pro 

            260                 265                 270         





Glu Tyr Thr Thr Val Ser Trp Leu Lys Asp Gly Thr Ser Leu Lys Lys 

        275                 280                 285             





Gln Asn Thr Phe Thr Leu Asn Leu Arg Glu Val Thr Lys Asp Gln Ser 

    290                 295                 300                 





Gly Lys Tyr Cys Cys Gln Val Ser Asn Asp Val Gly Pro Gly Arg Ser 

305                 310                 315                 320 





Glu Glu Val Phe Leu Gln Val Gln Tyr Ala Pro Glu Pro Ser Thr Val 

                325                 330                 335     





Gln Ile Leu His Ser Pro Ala Val Glu Gly Ser Gln Val Glu Phe Leu 

            340                 345                 350         





Cys Met Ser Leu Ala Asn Pro Leu Pro Thr Asn Tyr Thr Trp Tyr His 

        355                 360                 365             





Asn Gly Lys Glu Met Gln Gly Arg Thr Glu Glu Lys Val His Ile Pro 

    370                 375                 380                 





Lys Ile Leu Pro Trp His Ala Gly Thr Tyr Ser Cys Val Ala Glu Asn 

385                 390                 395                 400 





Ile Leu Gly Thr Gly Gln Arg Gly Pro Gly Ala Glu Leu Asp Val Gln 

                405                 410                 415     





Tyr Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met Pro Ile 

            420                 425                 430         





Arg Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser Ser Asn 

        435                 440                 445             





Pro Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp Glu Glu 

    450                 455                 460                 





Pro Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp Asn Thr 

465                 470                 475                 480 





Thr Ile Ala Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp Ala Ser Pro 

                485                 490                 495     





Val Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg Val Arg Lys 

            500                 505                 510         





Ile Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val Ser Leu Gln 

        515                 520                 525             





Cys Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe Phe Trp Glu 

    530                 535                 540                 





Lys Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn Phe Asp Ser 

545                 550                 555                 560 





Ile Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val Asn Asn Ser 

                565                 570                 575     





Ile Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val Leu Tyr Ala 

            580                 585                 590         





Pro Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln Val Met Glu 

        595                 600                 605             





Gly Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn Pro Pro Val 

    610                 615                 620                 





Ser His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu Pro Tyr His 

625                 630                 635                 640 





Ser Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His Ser Gly Ala 

                645                 650                 655     





Tyr Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg Ser Pro Leu 

            660                 665                 670         





Ser Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Ile Gly Arg Arg Val 

        675                 680                 685             





Ala Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile Cys 

    690                 695                 700                 





Gly Leu Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly 

705                 710                 715                 720 





Leu Gln Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys 

                725                 730                 735     





Val Arg Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr 

            740                 745                 750         





Asn Pro Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro 

        755                 760                 765             





Glu Met Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln 

    770                 775                 780                 





Arg Pro Pro Pro Asp Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His 

785                 790                 795                 800 





Lys Arg Gln Val Gly Asp Tyr Glu Asn Val Ile Pro Asp Phe Pro Glu 

                805                 810                 815     





Asp Glu Gly Ile His Tyr Ser Glu Leu Ile Gln Phe Gly Val Gly Glu 

            820                 825                 830         





Arg Pro Gln Ala Gln Glu Asn Val Asp Tyr Val Ile Leu Lys His 

        835                 840                 845         





<210>  165

<211>  595

<212>  PRT

<213>  Homo sapiens



<400>  165



Met Arg Val Leu Leu Ala Ala Leu Gly Leu Leu Phe Leu Gly Ala Leu 

1               5                   10                  15      





Arg Ala Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys His Gly Asn 

            20                  25                  30          





Pro Ser His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys 

        35                  40                  45              





Pro Met Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Thr Asp 

    50                  55                  60                  





Cys Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Asp Arg 

65                  70                  75                  80  





Cys Thr Ala Cys Val Thr Cys Ser Arg Asp Asp Leu Val Glu Lys Thr 

                85                  90                  95      





Pro Cys Ala Trp Asn Ser Ser Arg Val Cys Glu Cys Arg Pro Gly Met 

            100                 105                 110         





Phe Cys Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe His 

        115                 120                 125             





Ser Val Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala Gln 

    130                 135                 140                 





Lys Asn Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys 

145                 150                 155                 160 





Ala Ser Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln 

                165                 170                 175     





Ala Lys Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr Met 

            180                 185                 190         





Pro Val Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu 

        195                 200                 205             





Thr Arg Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp 

    210                 215                 220                 





Pro Gly Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp Cys 

225                 230                 235                 240 





Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys 

                245                 250                 255     





Thr Ala Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro 

            260                 265                 270         





Cys Ala Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met Ile 

        275                 280                 285             





Cys Ala Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr Pro 

    290                 295                 300                 





Ile Cys Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu Lys 

305                 310                 315                 320 





Asp Thr Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn 

                325                 330                 335     





Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln 

            340                 345                 350         





Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr 

        355                 360                 365             





Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp Ala 

    370                 375                 380                 





Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly 

385                 390                 395                 400 





Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg Ile 

                405                 410                 415     





Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys 

            420                 425                 430         





Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg 

        435                 440                 445             





Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met 

    450                 455                 460                 





Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu 

465                 470                 475                 480 





Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser 

                485                 490                 495     





Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn 

            500                 505                 510         





Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly 

        515                 520                 525             





Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala 

    530                 535                 540                 





Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr 

545                 550                 555                 560 





Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met 

                565                 570                 575     





Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala 

            580                 585                 590         





Ser Gly Lys 

        595 





<210>  166

<211>  483

<212>  PRT

<213>  Homo sapiens



<400>  166



Met Phe Cys Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe 

1               5                   10                  15      





His Ser Val Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala 

            20                  25                  30          





Gln Lys Asn Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala 

        35                  40                  45              





Cys Ala Ser Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro 

    50                  55                  60                  





Gln Ala Lys Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr 

65                  70                  75                  80  





Met Pro Val Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys 

                85                  90                  95      





Leu Thr Arg Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser 

            100                 105                 110         





Asp Pro Gly Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp 

        115                 120                 125             





Cys Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg 

    130                 135                 140                 





Cys Thr Ala Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr 

145                 150                 155                 160 





Pro Cys Ala Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met 

                165                 170                 175     





Ile Cys Ala Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr 

            180                 185                 190         





Pro Ile Cys Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu 

        195                 200                 205             





Lys Asp Thr Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys 

    210                 215                 220                 





Asn Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr 

225                 230                 235                 240 





Gln Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro 

                245                 250                 255     





Thr Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp 

            260                 265                 270         





Ala Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val 

        275                 280                 285             





Gly Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg 

    290                 295                 300                 





Ile Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro 

305                 310                 315                 320 





Lys Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Leu Arg 

                325                 330                 335     





Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met 

            340                 345                 350         





Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu 

        355                 360                 365             





Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser 

    370                 375                 380                 





Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn 

385                 390                 395                 400 





Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly 

                405                 410                 415     





Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala 

            420                 425                 430         





Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr 

        435                 440                 445             





Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met 

    450                 455                 460                 





Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala 

465                 470                 475                 480 





Ser Gly Lys 

            





<210>  167

<211>  237

<212>  PRT

<213>  Homo sapiens



<400>  167



Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Asp Leu Thr His 

1               5                   10                  15      





Arg Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys 

            20                  25                  30          





Asn Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro 

        35                  40                  45              





Ile Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr 

    50                  55                  60                  





Thr His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly 

65                  70                  75                  80  





Thr Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr 

                85                  90                  95      





Glu Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr 

            100                 105                 110         





Thr Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala 

        115                 120                 125             





Gly Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu 

    130                 135                 140                 





Ala Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg 

145                 150                 155                 160 





Lys Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr 

                165                 170                 175     





Gly Ser Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro 

            180                 185                 190         





Thr Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp 

        195                 200                 205             





Glu Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser 

    210                 215                 220                 





Lys Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln 

225                 230                 235         





<210>  168

<211>  310

<212>  PRT

<213>  Homo sapiens



<400>  168



Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 

1               5                   10                  15      





Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 

            20                  25                  30          





Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 

        35                  40                  45              





Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 

    50                  55                  60                  





Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 

65                  70                  75                  80  





Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 

                85                  90                  95      





Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 

            100                 105                 110         





Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 

        115                 120                 125             





Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 

    130                 135                 140                 





Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 

145                 150                 155                 160 





Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 

                165                 170                 175     





Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 

            180                 185                 190         





His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 

        195                 200                 205             





Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 

    210                 215                 220                 





Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 

225                 230                 235                 240 





Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 

                245                 250                 255     





Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala 

            260                 265                 270         





Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys 

        275                 280                 285             





Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly 

    290                 295                 300                 





Ser Ala Ser Pro Val Arg 

305                 310 





<210>  169

<211>  364

<212>  PRT

<213>  Homo sapiens



<400>  169



Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 

1               5                   10                  15      





Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 

            20                  25                  30          





Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 

        35                  40                  45              





Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 

    50                  55                  60                  





Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 

65                  70                  75                  80  





Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 

                85                  90                  95      





Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 

            100                 105                 110         





Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 

        115                 120                 125             





Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 

    130                 135                 140                 





Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 

145                 150                 155                 160 





Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 

                165                 170                 175     





Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 

            180                 185                 190         





His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 

        195                 200                 205             





Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 

    210                 215                 220                 





Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 

225                 230                 235                 240 





Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 

                245                 250                 255     





Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala 

            260                 265                 270         





Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys 

        275                 280                 285             





Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly 

    290                 295                 300                 





Ser Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro Thr 

305                 310                 315                 320 





Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu 

                325                 330                 335     





Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys 

            340                 345                 350         





Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln 

        355                 360                 





<210>  170

<211>  742

<212>  PRT

<213>  Homo sapiens



<400>  170



Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 

1               5                   10                  15      





Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 

            20                  25                  30          





Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 

        35                  40                  45              





Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 

    50                  55                  60                  





Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 

65                  70                  75                  80  





Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 

                85                  90                  95      





Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 

            100                 105                 110         





Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 

        115                 120                 125             





Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 

    130                 135                 140                 





Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 

145                 150                 155                 160 





Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 

                165                 170                 175     





Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 

            180                 185                 190         





Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 

        195                 200                 205             





Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu 

    210                 215                 220                 





Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu 

225                 230                 235                 240 





Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn 

                245                 250                 255     





His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile 

            260                 265                 270         





Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg 

        275                 280                 285             





His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile 

    290                 295                 300                 





Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln 

305                 310                 315                 320 





Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val 

                325                 330                 335     





Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr 

            340                 345                 350         





Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile 

        355                 360                 365             





His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr 

    370                 375                 380                 





Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys 

385                 390                 395                 400 





Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro 

                405                 410                 415     





Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His 

            420                 425                 430         





Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser 

        435                 440                 445             





Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly 

    450                 455                 460                 





His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Thr 

465                 470                 475                 480 





Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp 

                485                 490                 495     





Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser 

            500                 505                 510         





Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr 

        515                 520                 525             





Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg 

    530                 535                 540                 





Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr 

545                 550                 555                 560 





Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val 

                565                 570                 575     





Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly 

            580                 585                 590         





Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr 

        595                 600                 605             





Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp 

    610                 615                 620                 





Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly 

625                 630                 635                 640 





Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser 

                645                 650                 655     





Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser 

            660                 665                 670         





Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn 

        675                 680                 685             





Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser 

    690                 695                 700                 





Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr 

705                 710                 715                 720 





Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val 

                725                 730                 735     





Asp Met Lys Ile Gly Val 

            740         





<210>  171

<211>  699

<212>  PRT

<213>  Homo sapiens



<400>  171



Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 

1               5                   10                  15      





Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 

            20                  25                  30          





Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 

        35                  40                  45              





Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 

    50                  55                  60                  





Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 

65                  70                  75                  80  





Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 

                85                  90                  95      





Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 

            100                 105                 110         





Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 

        115                 120                 125             





Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 

    130                 135                 140                 





Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 

145                 150                 155                 160 





Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 

                165                 170                 175     





Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 

            180                 185                 190         





Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 

        195                 200                 205             





Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Ser Thr 

    210                 215                 220                 





Ser Ser Asn Thr Ile Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu 

225                 230                 235                 240 





Asp Glu Arg Asp Arg His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp 

                245                 250                 255     





Asp Glu Asp Phe Ile Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe 

            260                 265                 270         





Asp His Thr Lys Gln Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His 

        275                 280                 285             





Ser Asn Pro Glu Val Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val 

    290                 295                 300                 





Asp Arg Asn Gly Thr Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala 

305                 310                 315                 320 





His Pro Pro Leu Ile His His Glu His His Glu Glu Glu Glu Thr Pro 

                325                 330                 335     





His Ser Thr Ser Thr Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu 

            340                 345                 350         





Thr Ala Thr Gln Lys Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly 

        355                 360                 365             





Tyr Arg Gln Thr Pro Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala 

    370                 375                 380                 





Ala Ala Ser Ala His Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro 

385                 390                 395                 400 





Ser Pro Glu Asp Ser Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His 

                405                 410                 415     





Pro Met Gly Arg Gly His Gln Ala Gly Arg Arg Met Asp Met Asp Ser 

            420                 425                 430         





Ser His Ser Ile Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu 

        435                 440                 445             





Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln 

    450                 455                 460                 





Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp 

465                 470                 475                 480 





Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp 

                485                 490                 495     





Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr 

            500                 505                 510         





Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg 

        515                 520                 525             





Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr 

    530                 535                 540                 





Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser 

545                 550                 555                 560 





Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His 

                565                 570                 575     





Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala 

            580                 585                 590         





Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu 

        595                 600                 605             





Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys 

    610                 615                 620                 





Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val 

625                 630                 635                 640 





Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu 

                645                 650                 655     





Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys 

            660                 665                 670         





Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg 

        675                 680                 685             





Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val 

    690                 695                 





<210>  172

<211>  493

<212>  PRT

<213>  Homo sapiens



<400>  172



Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 

1               5                   10                  15      





Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 

            20                  25                  30          





Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 

        35                  40                  45              





Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 

    50                  55                  60                  





Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 

65                  70                  75                  80  





Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 

                85                  90                  95      





Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 

            100                 105                 110         





Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 

        115                 120                 125             





Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 

    130                 135                 140                 





Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 

145                 150                 155                 160 





Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 

                165                 170                 175     





Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 

            180                 185                 190         





Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 

        195                 200                 205             





Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Asn Met 

    210                 215                 220                 





Asp Ser Ser His Ser Ile Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr 

225                 230                 235                 240 





Gly Leu Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr 

                245                 250                 255     





Gln Gln Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu 

            260                 265                 270         





Glu Asp Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg 

        275                 280                 285             





Asn Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser 

    290                 295                 300                 





Thr Thr Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu 

305                 310                 315                 320 





Ser Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly 

                325                 330                 335     





Val Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser 

            340                 345                 350         





Leu Ser Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr 

        355                 360                 365             





Thr His Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly 

    370                 375                 380                 





Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu 

385                 390                 395                 400 





Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala 

                405                 410                 415     





Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys 

            420                 425                 430         





Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser 

        435                 440                 445             





Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val 

    450                 455                 460                 





Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu 

465                 470                 475                 480 





Thr Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val 

                485                 490             





<210>  173

<211>  361

<212>  PRT

<213>  Homo sapiens



<400>  173



Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 

1               5                   10                  15      





Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 

            20                  25                  30          





Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 

        35                  40                  45              





Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 

    50                  55                  60                  





Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 

65                  70                  75                  80  





Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 

                85                  90                  95      





Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 

            100                 105                 110         





Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 

        115                 120                 125             





Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 

    130                 135                 140                 





Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 

145                 150                 155                 160 





Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 

                165                 170                 175     





Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 

            180                 185                 190         





Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 

        195                 200                 205             





Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg Asp 

    210                 215                 220                 





Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser 

225                 230                 235                 240 





Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr 

                245                 250                 255     





Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile 

            260                 265                 270         





Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala 

        275                 280                 285             





Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn 

    290                 295                 300                 





Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly 

305                 310                 315                 320 





Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser 

                325                 330                 335     





Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu 

            340                 345                 350         





Gln Asn Val Asp Met Lys Ile Gly Val 

        355                 360     





<210>  174

<211>  139

<212>  PRT

<213>  Homo sapiens



<400>  174



Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 

1               5                   10                  15      





Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 

            20                  25                  30          





Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 

        35                  40                  45              





Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 

    50                  55                  60                  





Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Ser Leu His 

65                  70                  75                  80  





Cys Ser Gln Gln Ser Lys Lys Val Trp Ala Glu Glu Lys Ala Ser Asp 

                85                  90                  95      





Gln Gln Trp Gln Trp Ser Cys Gly Gly Gln Lys Ala Lys Trp Thr Gln 

            100                 105                 110         





Arg Arg Gly Gln Gln Val Ser Gly Asn Gly Ala Phe Gly Glu Gln Gly 

        115                 120                 125             





Val Val Arg Asn Ser Arg Pro Val Tyr Asp Ser 

    130                 135                 





<210>  175

<211>  429

<212>  PRT

<213>  Homo sapiens



<400>  175



Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 

1               5                   10                  15      





Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 

            20                  25                  30          





Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 

        35                  40                  45              





Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 

    50                  55                  60                  





Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 

65                  70                  75                  80  





Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 

                85                  90                  95      





Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 

            100                 105                 110         





Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 

        115                 120                 125             





Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 

    130                 135                 140                 





Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 

145                 150                 155                 160 





Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 

                165                 170                 175     





Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 

            180                 185                 190         





Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 

        195                 200                 205             





Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Asn Arg 

    210                 215                 220                 





Asn Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser 

225                 230                 235                 240 





Thr Thr Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu 

                245                 250                 255     





Ser Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly 

            260                 265                 270         





Val Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser 

        275                 280                 285             





Leu Ser Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr 

    290                 295                 300                 





Thr His Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly 

305                 310                 315                 320 





Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu 

                325                 330                 335     





Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala 

            340                 345                 350         





Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys 

        355                 360                 365             





Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser 

    370                 375                 380                 





Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val 

385                 390                 395                 400 





Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu 

                405                 410                 415     





Thr Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val 

            420                 425                 





<210>  176

<211>  340

<212>  PRT

<213>  Homo sapiens



<400>  176



Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 

1               5                   10                  15      





Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 

            20                  25                  30          





Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 

        35                  40                  45              





Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 

    50                  55                  60                  





Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 

65                  70                  75                  80  





Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 

                85                  90                  95      





Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 

            100                 105                 110         





Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 

        115                 120                 125             





Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 

    130                 135                 140                 





Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 

145                 150                 155                 160 





Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 

                165                 170                 175     





Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 

            180                 185                 190         





Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 

        195                 200                 205             





Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg His 

    210                 215                 220                 





Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly Pro Ile 

225                 230                 235                 240 





Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser Leu Leu 

                245                 250                 255     





Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser Arg Arg 

            260                 265                 270         





Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn Gly Ala 

        275                 280                 285             





Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser Lys Ser 

    290                 295                 300                 





Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr Pro Asp 

305                 310                 315                 320 





Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val Asp Met 

                325                 330                 335     





Lys Ile Gly Val 

            340 





<210>  177

<211>  294

<212>  PRT

<213>  Homo sapiens



<400>  177



Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 

1               5                   10                  15      





Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 

            20                  25                  30          





Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 

        35                  40                  45              





Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 

    50                  55                  60                  





Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 

65                  70                  75                  80  





Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 

                85                  90                  95      





Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 

            100                 105                 110         





Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 

        115                 120                 125             





Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 

    130                 135                 140                 





Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 

145                 150                 155                 160 





Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 

                165                 170                 175     





Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 

            180                 185                 190         





Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 

        195                 200                 205             





Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg Asp 

    210                 215                 220                 





Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser 

225                 230                 235                 240 





Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr 

                245                 250                 255     





Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile 

            260                 265                 270         





Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala 

        275                 280                 285             





Val Asn Ser Arg Arg Ser 

    290                 





<210>  178

<211>  314

<212>  PRT

<213>  Homo sapiens



<400>  178



Met Ala Pro Pro Gln Val Leu Ala Phe Gly Leu Leu Leu Ala Ala Ala 

1               5                   10                  15      





Thr Ala Thr Phe Ala Ala Ala Gln Glu Glu Cys Val Cys Glu Asn Tyr 

            20                  25                  30          





Lys Leu Ala Val Asn Cys Phe Val Asn Asn Asn Arg Gln Cys Gln Cys 

        35                  40                  45              





Thr Ser Val Gly Ala Gln Asn Thr Val Ile Cys Ser Lys Leu Ala Ala 

    50                  55                  60                  





Lys Cys Leu Val Met Lys Ala Glu Met Asn Gly Ser Lys Leu Gly Arg 

65                  70                  75                  80  





Arg Ala Lys Pro Glu Gly Ala Leu Gln Asn Asn Asp Gly Leu Tyr Asp 

                85                  90                  95      





Pro Asp Cys Asp Glu Ser Gly Leu Phe Lys Ala Lys Gln Cys Asn Gly 

            100                 105                 110         





Thr Ser Met Cys Trp Cys Val Asn Thr Ala Gly Val Arg Arg Thr Asp 

        115                 120                 125             





Lys Asp Thr Glu Ile Thr Cys Ser Glu Arg Val Arg Thr Tyr Trp Ile 

    130                 135                 140                 





Ile Ile Glu Leu Lys His Lys Ala Arg Glu Lys Pro Tyr Asp Ser Lys 

145                 150                 155                 160 





Ser Leu Arg Thr Ala Leu Gln Lys Glu Ile Thr Thr Arg Tyr Gln Leu 

                165                 170                 175     





Asp Pro Lys Phe Ile Thr Ser Ile Leu Tyr Glu Asn Asn Val Ile Thr 

            180                 185                 190         





Ile Asp Leu Val Gln Asn Ser Ser Gln Lys Thr Gln Asn Asp Val Asp 

        195                 200                 205             





Ile Ala Asp Val Ala Tyr Tyr Phe Glu Lys Asp Val Lys Gly Glu Ser 

    210                 215                 220                 





Leu Phe His Ser Lys Lys Met Asp Leu Thr Val Asn Gly Glu Gln Leu 

225                 230                 235                 240 





Asp Leu Asp Pro Gly Gln Thr Leu Ile Tyr Tyr Val Asp Glu Lys Ala 

                245                 250                 255     





Pro Glu Phe Ser Met Gln Gly Leu Lys Ala Gly Val Ile Ala Val Ile 

            260                 265                 270         





Val Val Val Val Ile Ala Val Val Ala Gly Ile Val Val Leu Val Ile 

        275                 280                 285             





Ser Arg Lys Lys Arg Met Ala Lys Tyr Glu Lys Ala Glu Ile Lys Glu 

    290                 295                 300                 





Met Gly Glu Met His Arg Glu Leu Asn Ala 

305                 310                 





<210>  179

<211>  1225

<212>  PRT

<213>  Homo sapiens



<400>  179



Met Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu 

1               5                   10                  15      





Arg His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu 

            20                  25                  30          





Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln 

        35                  40                  45              





Glu Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val 

    50                  55                  60                  





Pro Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp 

65                  70                  75                  80  





Asn Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr 

                85                  90                  95      





Thr Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu 

            100                 105                 110         





Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn 

        115                 120                 125             





Pro Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His 

    130                 135                 140                 





Lys Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg 

145                 150                 155                 160 





Ala Cys His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly 

                165                 170                 175     





Glu Ser Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly 

            180                 185                 190         





Gly Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu 

        195                 200                 205             





Gln Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala 

    210                 215                 220                 





Cys Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala 

225                 230                 235                 240 





Leu Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu 

                245                 250                 255     





Gly Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn 

            260                 265                 270         





Tyr Leu Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His 

        275                 280                 285             





Asn Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys 

    290                 295                 300                 





Ser Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu 

305                 310                 315                 320 





Arg Glu Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly 

                325                 330                 335     





Cys Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp 

            340                 345                 350         





Gly Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln 

        355                 360                 365             





Val Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala 

    370                 375                 380                 





Trp Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val 

385                 390                 395                 400 





Ile Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln 

                405                 410                 415     





Gly Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly 

            420                 425                 430         





Ser Gly Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His 

        435                 440                 445             





Thr Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu 

    450                 455                 460                 





His Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala 

465                 470                 475                 480 





Cys His Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr 

                485                 490                 495     





Gln Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu 

            500                 505                 510         





Glu Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg 

        515                 520                 525             





His Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val 

    530                 535                 540                 





Thr Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr 

545                 550                 555                 560 





Lys Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro 

                565                 570                 575     





Asp Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala 

            580                 585                 590         





Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp 

        595                 600                 605             





Asp Lys Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile 

    610                 615                 620                 





Ile Ser Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val 

625                 630                 635                 640 





Phe Gly Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr 

                645                 650                 655     





Met Arg Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro 

            660                 665                 670         





Ser Gly Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr 

        675                 680                 685             





Glu Leu Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val 

    690                 695                 700                 





Tyr Lys Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val 

705                 710                 715                 720 





Ala Ile Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu 

                725                 730                 735     





Ile Leu Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val 

            740                 745                 750         





Ser Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr 

        755                 760                 765             





Gln Leu Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg 

    770                 775                 780                 





Gly Arg Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala 

785                 790                 795                 800 





Lys Gly Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu 

                805                 810                 815     





Ala Ala Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr 

            820                 825                 830         





Asp Phe Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His 

        835                 840                 845             





Ala Asp Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile 

    850                 855                 860                 





Leu Arg Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val 

865                 870                 875                 880 





Thr Val Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile 

                885                 890                 895     





Pro Ala Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro 

            900                 905                 910         





Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys 

        915                 920                 925             





Trp Met Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser 

    930                 935                 940                 





Glu Phe Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln 

945                 950                 955                 960 





Asn Glu Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg 

                965                 970                 975     





Ser Leu Leu Glu Asp Asp Asp Met Gly Asp Leu Val Asp Ala Glu Glu 

            980                 985                 990         





Tyr Leu Val Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 

        995                 1000                 1005             





Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 

    1010                 1015                 1020             





Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 

    1025                 1030                 1035             





Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 

    1040                 1045                 1050             





Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 

    1055                 1060                 1065             





Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 

    1070                 1075                 1080             





Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 

    1085                 1090                 1095             





Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 

    1100                 1105                 1110             





Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 

    1115                 1120                 1125             





Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 

    1130                 1135                 1140             





Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 

    1145                 1150                 1155             





Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 

    1160                 1165                 1170             





Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 

    1175                 1180                 1185             





Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 

    1190                 1195                 1200             





Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 

    1205                 1210                 1215             





Leu Gly  Leu Asp Val Pro Val  

    1220                 1225 





<210>  180

<211>  1240

<212>  PRT

<213>  Homo sapiens



<400>  180



Met Pro Arg Gly Ser Trp Lys Pro Gln Val Cys Thr Gly Thr Asp Met 

1               5                   10                  15      





Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg 

            20                  25                  30          





His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr 

        35                  40                  45              





Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu 

    50                  55                  60                  





Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro 

65                  70                  75                  80  





Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn 

                85                  90                  95      





Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr 

            100                 105                 110         





Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg 

        115                 120                 125             





Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro 

    130                 135                 140                 





Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys 

145                 150                 155                 160 





Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala 

                165                 170                 175     





Cys His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu 

            180                 185                 190         





Ser Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly 

        195                 200                 205             





Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln 

    210                 215                 220                 





Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys 

225                 230                 235                 240 





Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu 

                245                 250                 255     





Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly 

            260                 265                 270         





Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr 

        275                 280                 285             





Leu Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn 

    290                 295                 300                 





Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser 

305                 310                 315                 320 





Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg 

                325                 330                 335     





Glu Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys 

            340                 345                 350         





Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly 

        355                 360                 365             





Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val 

    370                 375                 380                 





Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp 

385                 390                 395                 400 





Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile 

                405                 410                 415     





Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly 

            420                 425                 430         





Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser 

        435                 440                 445             





Gly Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr 

    450                 455                 460                 





Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His 

465                 470                 475                 480 





Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys 

                485                 490                 495     





His Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln 

            500                 505                 510         





Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu 

        515                 520                 525             





Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His 

    530                 535                 540                 





Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr 

545                 550                 555                 560 





Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys 

                565                 570                 575     





Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp 

            580                 585                 590         





Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys 

        595                 600                 605             





Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp 

    610                 615                 620                 





Lys Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile 

625                 630                 635                 640 





Ser Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe 

                645                 650                 655     





Gly Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met 

            660                 665                 670         





Arg Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser 

        675                 680                 685             





Gly Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu 

    690                 695                 700                 





Leu Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr 

705                 710                 715                 720 





Lys Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala 

                725                 730                 735     





Ile Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile 

            740                 745                 750         





Leu Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser 

        755                 760                 765             





Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln 

    770                 775                 780                 





Leu Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly 

785                 790                 795                 800 





Arg Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys 

                805                 810                 815     





Gly Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala 

            820                 825                 830         





Ala Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp 

        835                 840                 845             





Phe Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala 

    850                 855                 860                 





Asp Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu 

865                 870                 875                 880 





Arg Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr 

                885                 890                 895     





Val Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro 

            900                 905                 910         





Ala Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln 

        915                 920                 925             





Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp 

    930                 935                 940                 





Met Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu 

945                 950                 955                 960 





Phe Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn 

                965                 970                 975     





Glu Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg Ser 

            980                 985                 990         





Leu Leu Glu Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr 

        995                 1000                 1005             





Leu Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 

    1010                 1015                 1020             





Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 

    1025                 1030                 1035             





Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 

    1040                 1045                 1050             





Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 

    1055                 1060                 1065             





Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 

    1070                 1075                 1080             





Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 

    1085                 1090                 1095             





Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 

    1100                 1105                 1110             





Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 

    1115                 1120                 1125             





Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 

    1130                 1135                 1140             





Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 

    1145                 1150                 1155             





Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 

    1160                 1165                 1170             





Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 

    1175                 1180                 1185             





Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 

    1190                 1195                 1200             





Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 

    1205                 1210                 1215             





Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 

    1220                 1225                 1230             





Leu Gly  Leu Asp Val Pro Val  

    1235                 1240 





<210>  181

<211>  1055

<212>  PRT

<213>  Homo sapiens



<400>  181



Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 

1               5                   10                  15      





Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 

            20                  25                  30          





Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 

        35                  40                  45              





Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 

    50                  55                  60                  





Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 

65                  70                  75                  80  





Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 

                85                  90                  95      





Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 

            100                 105                 110         





Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 

        115                 120                 125             





Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 

    130                 135                 140                 





Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 

145                 150                 155                 160 





Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 

                165                 170                 175     





Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 

            180                 185                 190         





His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 

        195                 200                 205             





Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 

    210                 215                 220                 





Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 

225                 230                 235                 240 





Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 

                245                 250                 255     





His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 

            260                 265                 270         





Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 

        275                 280                 285             





Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 

    290                 295                 300                 





Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 

305                 310                 315                 320 





Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 

                325                 330                 335     





Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 

            340                 345                 350         





Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 

        355                 360                 365             





Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 

    370                 375                 380                 





Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 

385                 390                 395                 400 





Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 

                405                 410                 415     





Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 

            420                 425                 430         





Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 

        435                 440                 445             





Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 

    450                 455                 460                 





Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 

465                 470                 475                 480 





Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 

                485                 490                 495     





Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 

            500                 505                 510         





Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 

        515                 520                 525             





Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 

    530                 535                 540                 





Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 

545                 550                 555                 560 





Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 

                565                 570                 575     





Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 

            580                 585                 590         





Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 

        595                 600                 605             





Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 

    610                 615                 620                 





Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 

625                 630                 635                 640 





Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 

                645                 650                 655     





Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 

            660                 665                 670         





Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg 

        675                 680                 685             





Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly 

    690                 695                 700                 





Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu 

705                 710                 715                 720 





Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 

                725                 730                 735     





Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile 

            740                 745                 750         





Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu 

        755                 760                 765             





Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg 

    770                 775                 780                 





Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu 

785                 790                 795                 800 





Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg 

                805                 810                 815     





Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly 

            820                 825                 830         





Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala 

        835                 840                 845             





Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe 

    850                 855                 860                 





Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp 

865                 870                 875                 880 





Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg 

                885                 890                 895     





Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val 

            900                 905                 910         





Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala 

        915                 920                 925             





Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro 

    930                 935                 940                 





Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met 

945                 950                 955                 960 





Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe 

                965                 970                 975     





Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu 

            980                 985                 990         





Asp Leu Gly Pro Ala Ser Pro Leu  Asp Ser Thr Phe Tyr  Arg Ser Leu 

        995                 1000                 1005             





Leu Glu  Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr 

    1010                 1015                 1020             





Leu Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 

    1025                 1030                 1035             





Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 

    1040                 1045                 1050             





Asn Met  

    1055 





<210>  182

<211>  603

<212>  PRT

<213>  Homo sapiens



<400>  182



Met Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu 

1               5                   10                  15      





Arg His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu 

            20                  25                  30          





Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln 

        35                  40                  45              





Glu Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val 

    50                  55                  60                  





Pro Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp 

65                  70                  75                  80  





Asn Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr 

                85                  90                  95      





Thr Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu 

            100                 105                 110         





Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn 

        115                 120                 125             





Pro Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His 

    130                 135                 140                 





Lys Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg 

145                 150                 155                 160 





Ala Cys His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly 

                165                 170                 175     





Glu Ser Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly 

            180                 185                 190         





Gly Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu 

        195                 200                 205             





Gln Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala 

    210                 215                 220                 





Cys Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala 

225                 230                 235                 240 





Leu Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu 

                245                 250                 255     





Gly Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn 

            260                 265                 270         





Tyr Leu Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His 

        275                 280                 285             





Asn Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys 

    290                 295                 300                 





Ser Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu 

305                 310                 315                 320 





Arg Glu Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly 

                325                 330                 335     





Cys Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp 

            340                 345                 350         





Gly Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln 

        355                 360                 365             





Val Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala 

    370                 375                 380                 





Trp Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val 

385                 390                 395                 400 





Ile Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln 

                405                 410                 415     





Gly Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly 

            420                 425                 430         





Ser Gly Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His 

        435                 440                 445             





Thr Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu 

    450                 455                 460                 





His Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala 

465                 470                 475                 480 





Cys His Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr 

                485                 490                 495     





Gln Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu 

            500                 505                 510         





Glu Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg 

        515                 520                 525             





His Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val 

    530                 535                 540                 





Thr Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr 

545                 550                 555                 560 





Lys Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro 

                565                 570                 575     





Asp Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala 

            580                 585                 590         





Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser 

        595                 600             





<210>  183

<211>  1255

<212>  PRT

<213>  Homo sapiens



<400>  183



Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 

1               5                   10                  15      





Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 

            20                  25                  30          





Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 

        35                  40                  45              





Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 

    50                  55                  60                  





Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 

65                  70                  75                  80  





Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 

                85                  90                  95      





Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 

            100                 105                 110         





Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 

        115                 120                 125             





Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 

    130                 135                 140                 





Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 

145                 150                 155                 160 





Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 

                165                 170                 175     





Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 

            180                 185                 190         





His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 

        195                 200                 205             





Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 

    210                 215                 220                 





Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 

225                 230                 235                 240 





Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 

                245                 250                 255     





His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 

            260                 265                 270         





Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 

        275                 280                 285             





Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 

    290                 295                 300                 





Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 

305                 310                 315                 320 





Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 

                325                 330                 335     





Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 

            340                 345                 350         





Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 

        355                 360                 365             





Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 

    370                 375                 380                 





Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 

385                 390                 395                 400 





Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 

                405                 410                 415     





Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 

            420                 425                 430         





Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 

        435                 440                 445             





Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 

    450                 455                 460                 





Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 

465                 470                 475                 480 





Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 

                485                 490                 495     





Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 

            500                 505                 510         





Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 

        515                 520                 525             





Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 

    530                 535                 540                 





Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 

545                 550                 555                 560 





Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 

                565                 570                 575     





Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 

            580                 585                 590         





Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 

        595                 600                 605             





Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 

    610                 615                 620                 





Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 

625                 630                 635                 640 





Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 

                645                 650                 655     





Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 

            660                 665                 670         





Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg 

        675                 680                 685             





Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly 

    690                 695                 700                 





Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu 

705                 710                 715                 720 





Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 

                725                 730                 735     





Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile 

            740                 745                 750         





Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu 

        755                 760                 765             





Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg 

    770                 775                 780                 





Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu 

785                 790                 795                 800 





Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg 

                805                 810                 815     





Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly 

            820                 825                 830         





Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala 

        835                 840                 845             





Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe 

    850                 855                 860                 





Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp 

865                 870                 875                 880 





Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg 

                885                 890                 895     





Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val 

            900                 905                 910         





Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala 

        915                 920                 925             





Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro 

    930                 935                 940                 





Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met 

945                 950                 955                 960 





Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe 

                965                 970                 975     





Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu 

            980                 985                 990         





Asp Leu Gly Pro Ala Ser Pro Leu  Asp Ser Thr Phe Tyr  Arg Ser Leu 

        995                 1000                 1005             





Leu Glu  Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr 

    1010                 1015                 1020             





Leu Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 

    1025                 1030                 1035             





Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 

    1040                 1045                 1050             





Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 

    1055                 1060                 1065             





Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 

    1070                 1075                 1080             





Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 

    1085                 1090                 1095             





Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 

    1100                 1105                 1110             





Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 

    1115                 1120                 1125             





Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 

    1130                 1135                 1140             





Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 

    1145                 1150                 1155             





Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 

    1160                 1165                 1170             





Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 

    1175                 1180                 1185             





Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 

    1190                 1195                 1200             





Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 

    1205                 1210                 1215             





Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 

    1220                 1225                 1230             





Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 

    1235                 1240                 1245             





Leu Gly  Leu Asp Val Pro Val  

    1250                 1255 





<210>  184

<211>  183

<212>  PRT

<213>  Homo sapiens



<400>  184



Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 

1               5                   10                  15      





Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 

            20                  25                  30          





Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 

        35                  40                  45              





Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 

    50                  55                  60                  





Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 

65                  70                  75                  80  





Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 

                85                  90                  95      





Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 

            100                 105                 110         





Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 

        115                 120                 125             





His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Gly Gln Phe Pro 

    130                 135                 140                 





Met Val Pro Ser Gly Leu Thr Pro Gln Pro Ala Gln Asp Trp Tyr Leu 

145                 150                 155                 160 





Leu Asp Asp Asp Pro Arg Leu Leu Thr Leu Ser Ala Ser Ser Lys Val 

                165                 170                 175     





Pro Val Thr Leu Ala Ala Val 

            180             





<210>  185

<211>  1342

<212>  PRT

<213>  Homo sapiens



<400>  185



Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 

1               5                   10                  15      





Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 

            20                  25                  30          





Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 

        35                  40                  45              





Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 

    50                  55                  60                  





Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 

65                  70                  75                  80  





Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 

                85                  90                  95      





Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 

            100                 105                 110         





Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 

        115                 120                 125             





His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 

    130                 135                 140                 





Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 

145                 150                 155                 160 





Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val 

                165                 170                 175     





Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly 

            180                 185                 190         





Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr 

        195                 200                 205             





Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 

    210                 215                 220                 





Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 

225                 230                 235                 240 





Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 

                245                 250                 255     





Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 

            260                 265                 270         





Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 

        275                 280                 285             





Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 

    290                 295                 300                 





Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 

305                 310                 315                 320 





Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser 

                325                 330                 335     





Gly Ser Arg Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val 

            340                 345                 350         





Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu 

        355                 360                 365             





Asn Gly Asp Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu 

    370                 375                 380                 





Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln 

385                 390                 395                 400 





Ser Trp Pro Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr 

                405                 410                 415     





Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile 

            420                 425                 430         





Met Lys Asn Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu 

        435                 440                 445             





Ile Ser Ala Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr 

    450                 455                 460                 





His His Ser Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu 

465                 470                 475                 480 





Arg Leu Asp Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu 

                485                 490                 495     





Gly Lys Val Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro 

            500                 505                 510         





Gly Pro Gly Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val 

        515                 520                 525             





Cys Val Thr His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala 

    530                 535                 540                 





His Glu Ala Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Glu 

545                 550                 555                 560 





Gly Thr Ala Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys 

                565                 570                 575     





Ala His Phe Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly 

            580                 585                 590         





Val Leu Gly Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn 

        595                 600                 605             





Glu Cys Arg Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro 

    610                 615                 620                 





Glu Leu Gln Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr 

625                 630                 635                 640 





His Leu Thr Met Ala Leu Thr Val Ile Ala Gly Leu Val Val Ile Phe 

                645                 650                 655     





Met Met Leu Gly Gly Thr Phe Leu Tyr Trp Arg Gly Arg Arg Ile Gln 

            660                 665                 670         





Asn Lys Arg Ala Met Arg Arg Tyr Leu Glu Arg Gly Glu Ser Ile Glu 

        675                 680                 685             





Pro Leu Asp Pro Ser Glu Lys Ala Asn Lys Val Leu Ala Arg Ile Phe 

    690                 695                 700                 





Lys Glu Thr Glu Leu Arg Lys Leu Lys Val Leu Gly Ser Gly Val Phe 

705                 710                 715                 720 





Gly Thr Val His Lys Gly Val Trp Ile Pro Glu Gly Glu Ser Ile Lys 

                725                 730                 735     





Ile Pro Val Cys Ile Lys Val Ile Glu Asp Lys Ser Gly Arg Gln Ser 

            740                 745                 750         





Phe Gln Ala Val Thr Asp His Met Leu Ala Ile Gly Ser Leu Asp His 

        755                 760                 765             





Ala His Ile Val Arg Leu Leu Gly Leu Cys Pro Gly Ser Ser Leu Gln 

    770                 775                 780                 





Leu Val Thr Gln Tyr Leu Pro Leu Gly Ser Leu Leu Asp His Val Arg 

785                 790                 795                 800 





Gln His Arg Gly Ala Leu Gly Pro Gln Leu Leu Leu Asn Trp Gly Val 

                805                 810                 815     





Gln Ile Ala Lys Gly Met Tyr Tyr Leu Glu Glu His Gly Met Val His 

            820                 825                 830         





Arg Asn Leu Ala Ala Arg Asn Val Leu Leu Lys Ser Pro Ser Gln Val 

        835                 840                 845             





Gln Val Ala Asp Phe Gly Val Ala Asp Leu Leu Pro Pro Asp Asp Lys 

    850                 855                 860                 





Gln Leu Leu Tyr Ser Glu Ala Lys Thr Pro Ile Lys Trp Met Ala Leu 

865                 870                 875                 880 





Glu Ser Ile His Phe Gly Lys Tyr Thr His Gln Ser Asp Val Trp Ser 

                885                 890                 895     





Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ala Glu Pro Tyr 

            900                 905                 910         





Ala Gly Leu Arg Leu Ala Glu Val Pro Asp Leu Leu Glu Lys Gly Glu 

        915                 920                 925             





Arg Leu Ala Gln Pro Gln Ile Cys Thr Ile Asp Val Tyr Met Val Met 

    930                 935                 940                 





Val Lys Cys Trp Met Ile Asp Glu Asn Ile Arg Pro Thr Phe Lys Glu 

945                 950                 955                 960 





Leu Ala Asn Glu Phe Thr Arg Met Ala Arg Asp Pro Pro Arg Tyr Leu 

                965                 970                 975     





Val Ile Lys Arg Glu Ser Gly Pro Gly Ile Ala Pro Gly Pro Glu Pro 

            980                 985                 990         





His Gly Leu Thr Asn Lys Lys Leu  Glu Glu Val Glu Leu  Glu Pro Glu 

        995                 1000                 1005             





Leu Asp  Leu Asp Leu Asp Leu  Glu Ala Glu Glu Asp  Asn Leu Ala 

    1010                 1015                 1020             





Thr Thr  Thr Leu Gly Ser Ala  Leu Ser Leu Pro Val  Gly Thr Leu 

    1025                 1030                 1035             





Asn Arg  Pro Arg Gly Ser Gln  Ser Leu Leu Ser Pro  Ser Ser Gly 

    1040                 1045                 1050             





Tyr Met  Pro Met Asn Gln Gly  Asn Leu Gly Glu Ser  Cys Gln Glu 

    1055                 1060                 1065             





Ser Ala  Val Ser Gly Ser Ser  Glu Arg Cys Pro Arg  Pro Val Ser 

    1070                 1075                 1080             





Leu His  Pro Met Pro Arg Gly  Cys Leu Ala Ser Glu  Ser Ser Glu 

    1085                 1090                 1095             





Gly His  Val Thr Gly Ser Glu  Ala Glu Leu Gln Glu  Lys Val Ser 

    1100                 1105                 1110             





Met Cys  Arg Ser Arg Ser Arg  Ser Arg Ser Pro Arg  Pro Arg Gly 

    1115                 1120                 1125             





Asp Ser  Ala Tyr His Ser Gln  Arg His Ser Leu Leu  Thr Pro Val 

    1130                 1135                 1140             





Thr Pro  Leu Ser Pro Pro Gly  Leu Glu Glu Glu Asp  Val Asn Gly 

    1145                 1150                 1155             





Tyr Val  Met Pro Asp Thr His  Leu Lys Gly Thr Pro  Ser Ser Arg 

    1160                 1165                 1170             





Glu Gly  Thr Leu Ser Ser Val  Gly Leu Ser Ser Val  Leu Gly Thr 

    1175                 1180                 1185             





Glu Glu  Glu Asp Glu Asp Glu  Glu Tyr Glu Tyr Met  Asn Arg Arg 

    1190                 1195                 1200             





Arg Arg  His Ser Pro Pro His  Pro Pro Arg Pro Ser  Ser Leu Glu 

    1205                 1210                 1215             





Glu Leu  Gly Tyr Glu Tyr Met  Asp Val Gly Ser Asp  Leu Ser Ala 

    1220                 1225                 1230             





Ser Leu  Gly Ser Thr Gln Ser  Cys Pro Leu His Pro  Val Pro Ile 

    1235                 1240                 1245             





Met Pro  Thr Ala Gly Thr Thr  Pro Asp Glu Asp Tyr  Glu Tyr Met 

    1250                 1255                 1260             





Asn Arg  Gln Arg Asp Gly Gly  Gly Pro Gly Gly Asp  Tyr Ala Ala 

    1265                 1270                 1275             





Met Gly  Ala Cys Pro Ala Ser  Glu Gln Gly Tyr Glu  Glu Met Arg 

    1280                 1285                 1290             





Ala Phe  Gln Gly Pro Gly His  Gln Ala Pro His Val  His Tyr Ala 

    1295                 1300                 1305             





Arg Leu  Lys Thr Leu Arg Ser  Leu Glu Ala Thr Asp  Ser Ala Phe 

    1310                 1315                 1320             





Asp Asn  Pro Asp Tyr Trp His  Ser Arg Leu Phe Pro  Lys Ala Asn 

    1325                 1330                 1335             





Ala Gln  Arg Thr 

    1340         





<210>  186

<211>  665

<212>  PRT

<213>  Homo sapiens



<400>  186



Met Ala Asp Tyr Ser Thr Val Pro Pro Pro Ser Ser Gly Ser Ala Gly 

1               5                   10                  15      





Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Val Asn Asp Ala Phe Lys 

            20                  25                  30          





Asp Ala Leu Gln Arg Ala Arg Gln Ile Ala Ala Lys Ile Gly Gly Asp 

        35                  40                  45              





Ala Gly Thr Ser Leu Asn Ser Asn Asp Tyr Gly Tyr Gly Gly Gln Lys 

    50                  55                  60                  





Arg Pro Leu Glu Asp Gly Asp Gly Ser Trp Thr Ser Pro Ser Ser Thr 

65                  70                  75                  80  





Thr His Trp Glu Gly Met Pro Ser Pro Phe Lys Asp Gln Pro Asp Ala 

                85                  90                  95      





Lys Lys Val Ala Pro Gln Asn Asp Ser Phe Gly Thr Gln Leu Pro Pro 

            100                 105                 110         





Met His Gln Gln Gln Ser Arg Ser Val Met Thr Glu Glu Tyr Lys Val 

        115                 120                 125             





Pro Asp Gly Met Val Gly Phe Ile Ile Gly Arg Gly Gly Glu Gln Ile 

    130                 135                 140                 





Ser Arg Ile Gln Gln Glu Ser Gly Cys Lys Ile Gln Ile Ala Pro Asp 

145                 150                 155                 160 





Ser Gly Gly Leu Pro Glu Arg Ser Cys Met Leu Thr Gly Thr Pro Glu 

                165                 170                 175     





Ser Val Gln Ser Ala Lys Arg Leu Leu Asp Gln Ile Val Glu Lys Gly 

            180                 185                 190         





Arg Pro Ala Pro Gly Phe His His Gly Asp Gly Pro Gly Asn Ala Val 

        195                 200                 205             





Gln Glu Ile Met Ile Pro Ala Ser Lys Ala Gly Leu Val Ile Gly Lys 

    210                 215                 220                 





Gly Gly Glu Thr Ile Lys Gln Leu Gln Glu Arg Ala Gly Val Lys Met 

225                 230                 235                 240 





Val Met Ile Gln Asp Gly Pro Gln Asn Thr Gly Ala Asp Lys Pro Leu 

                245                 250                 255     





Arg Ile Thr Gly Asp Pro Tyr Lys Val Gln Gln Ala Lys Glu Met Val 

            260                 265                 270         





Leu Glu Leu Ile Arg Asp Gln Gly Gly Phe Arg Glu Val Arg Asn Glu 

        275                 280                 285             





Tyr Gly Ser Arg Ile Gly Gly Asn Glu Gly Ile Asp Val Pro Ile Pro 

    290                 295                 300                 





Arg Phe Ala Val Gly Ile Val Ile Gly Arg Asn Gly Glu Met Ile Lys 

305                 310                 315                 320 





Lys Ile Gln Asn Asp Ala Gly Val Arg Ile Gln Phe Lys Pro Asp Asp 

                325                 330                 335     





Gly Thr Thr Pro Glu Arg Ile Ala Gln Ile Thr Gly Pro Pro Asp Arg 

            340                 345                 350         





Cys Gln His Ala Ala Glu Ile Ile Thr Asp Leu Leu Arg Ser Val Gln 

        355                 360                 365             





Ala Gly Asn Pro Gly Gly Pro Gly Pro Gly Gly Arg Gly Arg Gly Arg 

    370                 375                 380                 





Gly Gln Gly Asn Trp Asn Met Gly Pro Pro Gly Gly Leu Gln Glu Phe 

385                 390                 395                 400 





Asn Phe Ile Val Pro Thr Gly Lys Thr Gly Leu Ile Ile Gly Lys Gly 

                405                 410                 415     





Gly Glu Thr Ile Lys Ser Ile Ser Gln Gln Ser Gly Ala Arg Ile Glu 

            420                 425                 430         





Leu Gln Arg Asn Pro Pro Pro Asn Ala Asp Pro Asn Met Lys Leu Phe 

        435                 440                 445             





Thr Ile Arg Gly Thr Pro Gln Gln Ile Asp Tyr Ala Arg Gln Leu Ile 

    450                 455                 460                 





Glu Glu Lys Ile Gly Gly Pro Val Asn Pro Leu Gly Pro Pro Val Pro 

465                 470                 475                 480 





His Gly Pro His Gly Val Pro Gly Pro His Gly Pro Pro Gly Pro Pro 

                485                 490                 495     





Gly Pro Gly Thr Pro Met Gly Pro Tyr Asn Pro Ala Pro Tyr Asn Pro 

            500                 505                 510         





Gly Pro Pro Gly Pro Ala Pro His Gly Pro Pro Ala Pro Tyr Ala Pro 

        515                 520                 525             





Gln Gly Trp Gly Asn Ala Tyr Pro His Trp Gln Gln Gln Ala Pro Pro 

    530                 535                 540                 





Asp Pro Ala Lys Ala Gly Thr Asp Pro Asn Ser Ala Ala Trp Ala Ala 

545                 550                 555                 560 





Tyr Tyr Ala His Tyr Tyr Gln Gln Gln Ala Gln Pro Pro Pro Ala Ala 

                565                 570                 575     





Pro Ala Gly Ala Pro Thr Thr Thr Gln Thr Asn Gly Gln Gly Asp Gln 

            580                 585                 590         





Gln Asn Pro Ala Pro Ala Gly Gln Val Asp Tyr Thr Lys Ala Trp Glu 

        595                 600                 605             





Glu Tyr Tyr Lys Lys Met Gly Gln Ala Val Pro Ala Pro Thr Gly Ala 

    610                 615                 620                 





Pro Pro Gly Gly Gln Pro Asp Tyr Ser Ala Ala Trp Ala Glu Tyr Tyr 

625                 630                 635                 640 





Arg Gln Gln Ala Ala Tyr Tyr Ala Gln Thr Ser Pro Gln Gly Met Pro 

                645                 650                 655     





Gln His Pro Pro Ala Pro Gln Gly Gln 

            660                 665 





<210>  187

<211>  644

<212>  PRT

<213>  Homo sapiens



<400>  187



Met Ala Asp Tyr Ser Thr Val Pro Pro Pro Ser Ser Gly Ser Ala Gly 

1               5                   10                  15      





Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Val Asn Asp Ala Phe Lys 

            20                  25                  30          





Asp Ala Leu Gln Arg Ala Arg Gln Ile Ala Ala Lys Ile Gly Gly Asp 

        35                  40                  45              





Ala Gly Thr Ser Leu Asn Ser Asn Asp Tyr Gly Tyr Gly Gly Gln Lys 

    50                  55                  60                  





Arg Pro Leu Glu Asp Gly Asp Gln Pro Asp Ala Lys Lys Val Ala Pro 

65                  70                  75                  80  





Gln Asn Asp Ser Phe Gly Thr Gln Leu Pro Pro Met His Gln Gln Gln 

                85                  90                  95      





Ser Arg Ser Val Met Thr Glu Glu Tyr Lys Val Pro Asp Gly Met Val 

            100                 105                 110         





Gly Phe Ile Ile Gly Arg Gly Gly Glu Gln Ile Ser Arg Ile Gln Gln 

        115                 120                 125             





Glu Ser Gly Cys Lys Ile Gln Ile Ala Pro Asp Ser Gly Gly Leu Pro 

    130                 135                 140                 





Glu Arg Ser Cys Met Leu Thr Gly Thr Pro Glu Ser Val Gln Ser Ala 

145                 150                 155                 160 





Lys Arg Leu Leu Asp Gln Ile Val Glu Lys Gly Arg Pro Ala Pro Gly 

                165                 170                 175     





Phe His His Gly Asp Gly Pro Gly Asn Ala Val Gln Glu Ile Met Ile 

            180                 185                 190         





Pro Ala Ser Lys Ala Gly Leu Val Ile Gly Lys Gly Gly Glu Thr Ile 

        195                 200                 205             





Lys Gln Leu Gln Glu Arg Ala Gly Val Lys Met Val Met Ile Gln Asp 

    210                 215                 220                 





Gly Pro Gln Asn Thr Gly Ala Asp Lys Pro Leu Arg Ile Thr Gly Asp 

225                 230                 235                 240 





Pro Tyr Lys Val Gln Gln Ala Lys Glu Met Val Leu Glu Leu Ile Arg 

                245                 250                 255     





Asp Gln Gly Gly Phe Arg Glu Val Arg Asn Glu Tyr Gly Ser Arg Ile 

            260                 265                 270         





Gly Gly Asn Glu Gly Ile Asp Val Pro Ile Pro Arg Phe Ala Val Gly 

        275                 280                 285             





Ile Val Ile Gly Arg Asn Gly Glu Met Ile Lys Lys Ile Gln Asn Asp 

    290                 295                 300                 





Ala Gly Val Arg Ile Gln Phe Lys Pro Asp Asp Gly Thr Thr Pro Glu 

305                 310                 315                 320 





Arg Ile Ala Gln Ile Thr Gly Pro Pro Asp Arg Cys Gln His Ala Ala 

                325                 330                 335     





Glu Ile Ile Thr Asp Leu Leu Arg Ser Val Gln Ala Gly Asn Pro Gly 

            340                 345                 350         





Gly Pro Gly Pro Gly Gly Arg Gly Arg Gly Arg Gly Gln Gly Asn Trp 

        355                 360                 365             





Asn Met Gly Pro Pro Gly Gly Leu Gln Glu Phe Asn Phe Ile Val Pro 

    370                 375                 380                 





Thr Gly Lys Thr Gly Leu Ile Ile Gly Lys Gly Gly Glu Thr Ile Lys 

385                 390                 395                 400 





Ser Ile Ser Gln Gln Ser Gly Ala Arg Ile Glu Leu Gln Arg Asn Pro 

                405                 410                 415     





Pro Pro Asn Ala Asp Pro Asn Met Lys Leu Phe Thr Ile Arg Gly Thr 

            420                 425                 430         





Pro Gln Gln Ile Asp Tyr Ala Arg Gln Leu Ile Glu Glu Lys Ile Gly 

        435                 440                 445             





Gly Pro Val Asn Pro Leu Gly Pro Pro Val Pro His Gly Pro His Gly 

    450                 455                 460                 





Val Pro Gly Pro His Gly Pro Pro Gly Pro Pro Gly Pro Gly Thr Pro 

465                 470                 475                 480 





Met Gly Pro Tyr Asn Pro Ala Pro Tyr Asn Pro Gly Pro Pro Gly Pro 

                485                 490                 495     





Ala Pro His Gly Pro Pro Ala Pro Tyr Ala Pro Gln Gly Trp Gly Asn 

            500                 505                 510         





Ala Tyr Pro His Trp Gln Gln Gln Ala Pro Pro Asp Pro Ala Lys Ala 

        515                 520                 525             





Gly Thr Asp Pro Asn Ser Ala Ala Trp Ala Ala Tyr Tyr Ala His Tyr 

    530                 535                 540                 





Tyr Gln Gln Gln Ala Gln Pro Pro Pro Ala Ala Pro Ala Gly Ala Pro 

545                 550                 555                 560 





Thr Thr Thr Gln Thr Asn Gly Gln Gly Asp Gln Gln Asn Pro Ala Pro 

                565                 570                 575     





Ala Gly Gln Val Asp Tyr Thr Lys Ala Trp Glu Glu Tyr Tyr Lys Lys 

            580                 585                 590         





Met Gly Gln Ala Val Pro Ala Pro Thr Gly Ala Pro Pro Gly Gly Gln 

        595                 600                 605             





Pro Asp Tyr Ser Ala Ala Trp Ala Glu Tyr Tyr Arg Gln Gln Ala Ala 

    610                 615                 620                 





Tyr Tyr Ala Gln Thr Ser Pro Gln Gly Met Pro Gln His Pro Pro Ala 

625                 630                 635                 640 





Pro Gln Gly Gln 

                





<210>  188

<211>  380

<212>  PRT

<213>  Homo sapiens



<400>  188



Met Ala Phe Val Cys Leu Ala Ile Gly Cys Leu Tyr Thr Phe Leu Ile 

1               5                   10                  15      





Ser Thr Thr Phe Gly Cys Thr Ser Ser Ser Asp Thr Glu Ile Lys Val 

            20                  25                  30          





Asn Pro Pro Gln Asp Phe Glu Ile Val Asp Pro Gly Tyr Leu Gly Tyr 

        35                  40                  45              





Leu Tyr Leu Gln Trp Gln Pro Pro Leu Ser Leu Asp His Phe Lys Glu 

    50                  55                  60                  





Cys Thr Val Glu Tyr Glu Leu Lys Tyr Arg Asn Ile Gly Ser Glu Thr 

65                  70                  75                  80  





Trp Lys Thr Ile Ile Thr Lys Asn Leu His Tyr Lys Asp Gly Phe Asp 

                85                  90                  95      





Leu Asn Lys Gly Ile Glu Ala Lys Ile His Thr Leu Leu Pro Trp Gln 

            100                 105                 110         





Cys Thr Asn Gly Ser Glu Val Gln Ser Ser Trp Ala Glu Thr Thr Tyr 

        115                 120                 125             





Trp Ile Ser Pro Gln Gly Ile Pro Glu Thr Lys Val Gln Asp Met Asp 

    130                 135                 140                 





Cys Val Tyr Tyr Asn Trp Gln Tyr Leu Leu Cys Ser Trp Lys Pro Gly 

145                 150                 155                 160 





Ile Gly Val Leu Leu Asp Thr Asn Tyr Asn Leu Phe Tyr Trp Tyr Glu 

                165                 170                 175     





Gly Leu Asp His Ala Leu Gln Cys Val Asp Tyr Ile Lys Ala Asp Gly 

            180                 185                 190         





Gln Asn Ile Gly Cys Arg Phe Pro Tyr Leu Glu Ala Ser Asp Tyr Lys 

        195                 200                 205             





Asp Phe Tyr Ile Cys Val Asn Gly Ser Ser Glu Asn Lys Pro Ile Arg 

    210                 215                 220                 





Ser Ser Tyr Phe Thr Phe Gln Leu Gln Asn Ile Val Lys Pro Leu Pro 

225                 230                 235                 240 





Pro Val Tyr Leu Thr Phe Thr Arg Glu Ser Ser Cys Glu Ile Lys Leu 

                245                 250                 255     





Lys Trp Ser Ile Pro Leu Gly Pro Ile Pro Ala Arg Cys Phe Asp Tyr 

            260                 265                 270         





Glu Ile Glu Ile Arg Glu Asp Asp Thr Thr Leu Val Thr Ala Thr Val 

        275                 280                 285             





Glu Asn Glu Thr Tyr Thr Leu Lys Thr Thr Asn Glu Thr Arg Gln Leu 

    290                 295                 300                 





Cys Phe Val Val Arg Ser Lys Val Asn Ile Tyr Cys Ser Asp Asp Gly 

305                 310                 315                 320 





Ile Trp Ser Glu Trp Ser Asp Lys Gln Cys Trp Glu Gly Glu Asp Leu 

                325                 330                 335     





Ser Lys Lys Thr Leu Leu Arg Phe Trp Leu Pro Phe Gly Phe Ile Leu 

            340                 345                 350         





Ile Leu Val Ile Phe Val Thr Gly Leu Leu Leu Arg Lys Pro Asn Thr 

        355                 360                 365             





Tyr Pro Lys Met Ile Pro Glu Phe Phe Cys Asp Thr 

    370                 375                 380 





<210>  189

<211>  1356

<212>  PRT

<213>  Homo sapiens



<400>  189



Met Gln Ser Lys Val Leu Leu Ala Val Ala Leu Trp Leu Cys Val Glu 

1               5                   10                  15      





Thr Arg Ala Ala Ser Val Gly Leu Pro Ser Val Ser Leu Asp Leu Pro 

            20                  25                  30          





Arg Leu Ser Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr Thr 

        35                  40                  45              





Leu Gln Ile Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro 

    50                  55                  60                  





Asn Asn Gln Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys Ser 

65                  70                  75                  80  





Asp Gly Leu Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly Asn 

                85                  90                  95      





Asp Thr Gly Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala Ser 

            100                 105                 110         





Val Ile Tyr Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala Ser 

        115                 120                 125             





Val Ser Asp Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys 

    130                 135                 140                 





Thr Val Val Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser 

145                 150                 155                 160 





Leu Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg 

                165                 170                 175     





Ile Ser Trp Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile 

            180                 185                 190         





Ser Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser 

        195                 200                 205             





Tyr Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr 

    210                 215                 220                 





Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu 

225                 230                 235                 240 





Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile 

                245                 250                 255     





Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu 

            260                 265                 270         





Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe 

        275                 280                 285             





Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu 

    290                 295                 300                 





Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr 

305                 310                 315                 320 





Phe Val Arg Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly Met 

                325                 330                 335     





Glu Ser Leu Val Glu Ala Thr Val Gly Glu Arg Val Arg Ile Pro Ala 

            340                 345                 350         





Lys Tyr Leu Gly Tyr Pro Pro Pro Glu Ile Lys Trp Tyr Lys Asn Gly 

        355                 360                 365             





Ile Pro Leu Glu Ser Asn His Thr Ile Lys Ala Gly His Val Leu Thr 

    370                 375                 380                 





Ile Met Glu Val Ser Glu Arg Asp Thr Gly Asn Tyr Thr Val Ile Leu 

385                 390                 395                 400 





Thr Asn Pro Ile Ser Lys Glu Lys Gln Ser His Val Val Ser Leu Val 

                405                 410                 415     





Val Tyr Val Pro Pro Gln Ile Gly Glu Lys Ser Leu Ile Ser Pro Val 

            420                 425                 430         





Asp Ser Tyr Gln Tyr Gly Thr Thr Gln Thr Leu Thr Cys Thr Val Tyr 

        435                 440                 445             





Ala Ile Pro Pro Pro His His Ile His Trp Tyr Trp Gln Leu Glu Glu 

    450                 455                 460                 





Glu Cys Ala Asn Glu Pro Ser Gln Ala Val Ser Val Thr Asn Pro Tyr 

465                 470                 475                 480 





Pro Cys Glu Glu Trp Arg Ser Val Glu Asp Phe Gln Gly Gly Asn Lys 

                485                 490                 495     





Ile Glu Val Asn Lys Asn Gln Phe Ala Leu Ile Glu Gly Lys Asn Lys 

            500                 505                 510         





Thr Val Ser Thr Leu Val Ile Gln Ala Ala Asn Val Ser Ala Leu Tyr 

        515                 520                 525             





Lys Cys Glu Ala Val Asn Lys Val Gly Arg Gly Glu Arg Val Ile Ser 

    530                 535                 540                 





Phe His Val Thr Arg Gly Pro Glu Ile Thr Leu Gln Pro Asp Met Gln 

545                 550                 555                 560 





Pro Thr Glu Gln Glu Ser Val Ser Leu Trp Cys Thr Ala Asp Arg Ser 

                565                 570                 575     





Thr Phe Glu Asn Leu Thr Trp Tyr Lys Leu Gly Pro Gln Pro Leu Pro 

            580                 585                 590         





Ile His Val Gly Glu Leu Pro Thr Pro Val Cys Lys Asn Leu Asp Thr 

        595                 600                 605             





Leu Trp Lys Leu Asn Ala Thr Met Phe Ser Asn Ser Thr Asn Asp Ile 

    610                 615                 620                 





Leu Ile Met Glu Leu Lys Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr 

625                 630                 635                 640 





Val Cys Leu Ala Gln Asp Arg Lys Thr Lys Lys Arg His Cys Val Val 

                645                 650                 655     





Arg Gln Leu Thr Val Leu Glu Arg Val Ala Pro Thr Ile Thr Gly Asn 

            660                 665                 670         





Leu Glu Asn Gln Thr Thr Ser Ile Gly Glu Ser Ile Glu Val Ser Cys 

        675                 680                 685             





Thr Ala Ser Gly Asn Pro Pro Pro Gln Ile Met Trp Phe Lys Asp Asn 

    690                 695                 700                 





Glu Thr Leu Val Glu Asp Ser Gly Ile Val Leu Lys Asp Gly Asn Arg 

705                 710                 715                 720 





Asn Leu Thr Ile Arg Arg Val Arg Lys Glu Asp Glu Gly Leu Tyr Thr 

                725                 730                 735     





Cys Gln Ala Cys Ser Val Leu Gly Cys Ala Lys Val Glu Ala Phe Phe 

            740                 745                 750         





Ile Ile Glu Gly Ala Gln Glu Lys Thr Asn Leu Glu Ile Ile Ile Leu 

        755                 760                 765             





Val Gly Thr Ala Val Ile Ala Met Phe Phe Trp Leu Leu Leu Val Ile 

    770                 775                 780                 





Ile Leu Arg Thr Val Lys Arg Ala Asn Gly Gly Glu Leu Lys Thr Gly 

785                 790                 795                 800 





Tyr Leu Ser Ile Val Met Asp Pro Asp Glu Leu Pro Leu Asp Glu His 

                805                 810                 815     





Cys Glu Arg Leu Pro Tyr Asp Ala Ser Lys Trp Glu Phe Pro Arg Asp 

            820                 825                 830         





Arg Leu Lys Leu Gly Lys Pro Leu Gly Arg Gly Ala Phe Gly Gln Val 

        835                 840                 845             





Ile Glu Ala Asp Ala Phe Gly Ile Asp Lys Thr Ala Thr Cys Arg Thr 

    850                 855                 860                 





Val Ala Val Lys Met Leu Lys Glu Gly Ala Thr His Ser Glu His Arg 

865                 870                 875                 880 





Ala Leu Met Ser Glu Leu Lys Ile Leu Ile His Ile Gly His His Leu 

                885                 890                 895     





Asn Val Val Asn Leu Leu Gly Ala Cys Thr Lys Pro Gly Gly Pro Leu 

            900                 905                 910         





Met Val Ile Val Glu Phe Cys Lys Phe Gly Asn Leu Ser Thr Tyr Leu 

        915                 920                 925             





Arg Ser Lys Arg Asn Glu Phe Val Pro Tyr Lys Thr Lys Gly Ala Arg 

    930                 935                 940                 





Phe Arg Gln Gly Lys Asp Tyr Val Gly Ala Ile Pro Val Asp Leu Lys 

945                 950                 955                 960 





Arg Arg Leu Asp Ser Ile Thr Ser Ser Gln Ser Ser Ala Ser Ser Gly 

                965                 970                 975     





Phe Val Glu Glu Lys Ser Leu Ser Asp Val Glu Glu Glu Glu Ala Pro 

            980                 985                 990         





Glu Asp Leu Tyr Lys Asp Phe Leu  Thr Leu Glu His Leu  Ile Cys Tyr 

        995                 1000                 1005             





Ser Phe  Gln Val Ala Lys Gly  Met Glu Phe Leu Ala  Ser Arg Lys 

    1010                 1015                 1020             





Cys Ile  His Arg Asp Leu Ala  Ala Arg Asn Ile Leu  Leu Ser Glu 

    1025                 1030                 1035             





Lys Asn  Val Val Lys Ile Cys  Asp Phe Gly Leu Ala  Arg Asp Ile 

    1040                 1045                 1050             





Tyr Lys  Asp Pro Asp Tyr Val  Arg Lys Gly Asp Ala  Arg Leu Pro 

    1055                 1060                 1065             





Leu Lys  Trp Met Ala Pro Glu  Thr Ile Phe Asp Arg  Val Tyr Thr 

    1070                 1075                 1080             





Ile Gln  Ser Asp Val Trp Ser  Phe Gly Val Leu Leu  Trp Glu Ile 

    1085                 1090                 1095             





Phe Ser  Leu Gly Ala Ser Pro  Tyr Pro Gly Val Lys  Ile Asp Glu 

    1100                 1105                 1110             





Glu Phe  Cys Arg Arg Leu Lys  Glu Gly Thr Arg Met  Arg Ala Pro 

    1115                 1120                 1125             





Asp Tyr  Thr Thr Pro Glu Met  Tyr Gln Thr Met Leu  Asp Cys Trp 

    1130                 1135                 1140             





His Gly  Glu Pro Ser Gln Arg  Pro Thr Phe Ser Glu  Leu Val Glu 

    1145                 1150                 1155             





His Leu  Gly Asn Leu Leu Gln  Ala Asn Ala Gln Gln  Asp Gly Lys 

    1160                 1165                 1170             





Asp Tyr  Ile Val Leu Pro Ile  Ser Glu Thr Leu Ser  Met Glu Glu 

    1175                 1180                 1185             





Asp Ser  Gly Leu Ser Leu Pro  Thr Ser Pro Val Ser  Cys Met Glu 

    1190                 1195                 1200             





Glu Glu  Glu Val Cys Asp Pro  Lys Phe His Tyr Asp  Asn Thr Ala 

    1205                 1210                 1215             





Gly Ile  Ser Gln Tyr Leu Gln  Asn Ser Lys Arg Lys  Ser Arg Pro 

    1220                 1225                 1230             





Val Ser  Val Lys Thr Phe Glu  Asp Ile Pro Leu Glu  Glu Pro Glu 

    1235                 1240                 1245             





Val Lys  Val Ile Pro Asp Asp  Asn Gln Thr Asp Ser  Gly Met Val 

    1250                 1255                 1260             





Leu Ala  Ser Glu Glu Leu Lys  Thr Leu Glu Asp Arg  Thr Lys Leu 

    1265                 1270                 1275             





Ser Pro  Ser Phe Gly Gly Met  Val Pro Ser Lys Ser  Arg Glu Ser 

    1280                 1285                 1290             





Val Ala  Ser Glu Gly Ser Asn  Gln Thr Ser Gly Tyr  Gln Ser Gly 

    1295                 1300                 1305             





Tyr His  Ser Asp Asp Thr Asp  Thr Thr Val Tyr Ser  Ser Glu Glu 

    1310                 1315                 1320             





Ala Glu  Leu Leu Lys Leu Ile  Glu Ile Gly Val Gln  Thr Gly Ser 

    1325                 1330                 1335             





Thr Ala  Gln Ile Leu Gln Pro  Asp Ser Gly Thr Thr  Leu Ser Ser 

    1340                 1345                 1350             





Pro Pro  Val 

    1355     





<210>  190

<211>  317

<212>  PRT

<213>  Homo sapiens



<400>  190



Met Phe Gln Ala Ala Glu Arg Pro Gln Glu Trp Ala Met Glu Gly Pro 

1               5                   10                  15      





Arg Asp Gly Leu Lys Lys Glu Arg Leu Leu Asp Asp Arg His Asp Ser 

            20                  25                  30          





Gly Leu Asp Ser Met Lys Asp Glu Glu Tyr Glu Gln Met Val Lys Glu 

        35                  40                  45              





Leu Gln Glu Ile Arg Leu Glu Pro Gln Glu Val Pro Arg Gly Ser Glu 

    50                  55                  60                  





Pro Trp Lys Gln Gln Leu Thr Glu Asp Gly Asp Ser Phe Leu His Leu 

65                  70                  75                  80  





Ala Ile Ile His Glu Glu Lys Ala Leu Thr Met Glu Val Ile Arg Gln 

                85                  90                  95      





Val Lys Gly Asp Leu Ala Phe Leu Asn Phe Gln Asn Asn Leu Gln Gln 

            100                 105                 110         





Thr Pro Leu His Leu Ala Val Ile Thr Asn Gln Pro Glu Ile Ala Glu 

        115                 120                 125             





Ala Leu Leu Gly Ala Gly Cys Asp Pro Glu Leu Arg Asp Phe Arg Gly 

    130                 135                 140                 





Asn Thr Pro Leu His Leu Ala Cys Glu Gln Gly Cys Leu Ala Ser Val 

145                 150                 155                 160 





Gly Val Leu Thr Gln Ser Cys Thr Thr Pro His Leu His Ser Ile Leu 

                165                 170                 175     





Lys Ala Thr Asn Tyr Asn Gly His Thr Cys Leu His Leu Ala Ser Ile 

            180                 185                 190         





His Gly Tyr Leu Gly Ile Val Glu Leu Leu Val Ser Leu Gly Ala Asp 

        195                 200                 205             





Val Asn Ala Gln Glu Pro Cys Asn Gly Arg Thr Ala Leu His Leu Ala 

    210                 215                 220                 





Val Asp Leu Gln Asn Pro Asp Leu Val Ser Leu Leu Leu Lys Cys Gly 

225                 230                 235                 240 





Ala Asp Val Asn Arg Val Thr Tyr Gln Gly Tyr Ser Pro Tyr Gln Leu 

                245                 250                 255     





Thr Trp Gly Arg Pro Ser Thr Arg Ile Gln Gln Gln Leu Gly Gln Leu 

            260                 265                 270         





Thr Leu Glu Asn Leu Gln Met Leu Pro Glu Ser Glu Asp Glu Glu Ser 

        275                 280                 285             





Tyr Asp Thr Glu Ser Glu Phe Thr Glu Phe Thr Glu Asp Glu Leu Pro 

    290                 295                 300                 





Tyr Asp Asp Cys Val Phe Gly Gly Gln Arg Leu Thr Leu 

305                 310                 315         





<210>  191

<211>  157

<212>  PRT

<213>  Homo sapiens



<400>  191



Met Asp Pro Arg Leu Pro Ala Trp Ala Leu Val Leu Leu Gly Pro Ala 

1               5                   10                  15      





Leu Val Phe Ala Leu Gly Pro Ala Pro Thr Pro Glu Met Arg Glu Lys 

            20                  25                  30          





Leu Cys Gly His His Phe Val Arg Ala Leu Val Arg Val Cys Gly Gly 

        35                  40                  45              





Pro Arg Trp Ser Thr Glu Ala Arg Arg Pro Ala Thr Gly Gly Asp Gln 

    50                  55                  60                  





Arg Glu Ser His Ser Val Ser Gln Ala Gly Leu Lys Leu Leu Ser Ser 

65                  70                  75                  80  





Ser Asn Pro Pro Thr Leu Thr Phe Gln Ser Val Gly Ile Ser Asp Val 

                85                  90                  95      





Ser Cys Tyr Ser Gly Trp Arg Asp Asp Ile Cys Ser Met Gly Trp Trp 

            100                 105                 110         





Pro Thr Val Ile Ser Arg Trp Asp Leu Ala Cys Ser Pro Cys Pro Arg 

        115                 120                 125             





Pro Leu Thr Ile Thr Ala Thr Thr Val Gln Leu Pro Pro Thr Leu His 

    130                 135                 140                 





Ala Thr Ala Ala Ser Val Ala Val Pro Asn Lys Thr Cys 

145                 150                 155         





<210>  192

<211>  131

<212>  PRT

<213>  Homo sapiens



<400>  192



Met Asp Pro Arg Leu Pro Ala Trp Ala Leu Val Leu Leu Gly Pro Ala 

1               5                   10                  15      





Leu Val Phe Ala Leu Gly Pro Ala Pro Thr Pro Glu Met Arg Glu Lys 

            20                  25                  30          





Leu Cys Gly His His Phe Val Arg Ala Leu Val Arg Val Cys Gly Gly 

        35                  40                  45              





Pro Arg Trp Ser Thr Glu Ala Arg Arg Pro Ala Thr Gly Gly Asp Arg 

    50                  55                  60                  





Glu Leu Leu Gln Trp Leu Glu Arg Arg His Leu Leu His Gly Leu Val 

65                  70                  75                  80  





Ala Asp Ser Asn Leu Thr Leu Gly Pro Gly Leu Gln Pro Leu Pro Gln 

                85                  90                  95      





Thr Ser His His His Arg His His Arg Ala Ala Ala Thr Asn Pro Ala 

            100                 105                 110         





Arg Tyr Cys Cys Leu Ser Gly Cys Thr Gln Gln Asp Leu Leu Thr Leu 

        115                 120                 125             





Cys Pro Tyr 

    130     





<210>  193

<211>  1257

<212>  PRT

<213>  Homo sapiens



<400>  193



Met Val Val Ala Leu Arg Tyr Val Trp Pro Leu Leu Leu Cys Ser Pro 

1               5                   10                  15      





Cys Leu Leu Ile Gln Ile Pro Glu Glu Tyr Glu Gly His His Val Met 

            20                  25                  30          





Glu Pro Pro Val Ile Thr Glu Gln Ser Pro Arg Arg Leu Val Val Phe 

        35                  40                  45              





Pro Thr Asp Asp Ile Ser Leu Lys Cys Glu Ala Ser Gly Lys Pro Glu 

    50                  55                  60                  





Val Gln Phe Arg Trp Thr Arg Asp Gly Val His Phe Lys Pro Lys Glu 

65                  70                  75                  80  





Glu Leu Gly Val Thr Val Tyr Gln Ser Pro His Ser Gly Ser Phe Thr 

                85                  90                  95      





Ile Thr Gly Asn Asn Ser Asn Phe Ala Gln Arg Phe Gln Gly Ile Tyr 

            100                 105                 110         





Arg Cys Phe Ala Ser Asn Lys Leu Gly Thr Ala Met Ser His Glu Ile 

        115                 120                 125             





Arg Leu Met Ala Glu Gly Ala Pro Lys Trp Pro Lys Glu Thr Val Lys 

    130                 135                 140                 





Pro Val Glu Val Glu Glu Gly Glu Ser Val Val Leu Pro Cys Asn Pro 

145                 150                 155                 160 





Pro Pro Ser Ala Glu Pro Leu Arg Ile Tyr Trp Met Asn Ser Lys Ile 

                165                 170                 175     





Leu His Ile Lys Gln Asp Glu Arg Val Thr Met Gly Gln Asn Gly Asn 

            180                 185                 190         





Leu Tyr Phe Ala Asn Val Leu Thr Ser Asp Asn His Ser Asp Tyr Ile 

        195                 200                 205             





Cys His Ala His Phe Pro Gly Thr Arg Thr Ile Ile Gln Lys Glu Pro 

    210                 215                 220                 





Ile Asp Leu Arg Val Lys Ala Thr Asn Ser Met Ile Asp Arg Lys Pro 

225                 230                 235                 240 





Arg Leu Leu Phe Pro Thr Asn Ser Ser Ser His Leu Val Ala Leu Gln 

                245                 250                 255     





Gly Gln Pro Leu Val Leu Glu Cys Ile Ala Glu Gly Phe Pro Thr Pro 

            260                 265                 270         





Thr Ile Lys Trp Leu Arg Pro Ser Gly Pro Met Pro Ala Asp Arg Val 

        275                 280                 285             





Thr Tyr Gln Asn His Asn Lys Thr Leu Gln Leu Leu Lys Val Gly Glu 

    290                 295                 300                 





Glu Asp Asp Gly Glu Tyr Arg Cys Leu Ala Glu Asn Ser Leu Gly Ser 

305                 310                 315                 320 





Ala Arg His Ala Tyr Tyr Val Thr Val Glu Ala Ala Pro Tyr Trp Leu 

                325                 330                 335     





His Lys Pro Gln Ser His Leu Tyr Gly Pro Gly Glu Thr Ala Arg Leu 

            340                 345                 350         





Asp Cys Gln Val Gln Gly Arg Pro Gln Pro Glu Val Thr Trp Arg Ile 

        355                 360                 365             





Asn Gly Ile Pro Val Glu Glu Leu Ala Lys Asp Gln Lys Tyr Arg Ile 

    370                 375                 380                 





Gln Arg Gly Ala Leu Ile Leu Ser Asn Val Gln Pro Ser Asp Thr Met 

385                 390                 395                 400 





Val Thr Gln Cys Glu Ala Arg Asn Arg His Gly Leu Leu Leu Ala Asn 

                405                 410                 415     





Ala Tyr Ile Tyr Val Val Gln Leu Pro Ala Lys Ile Leu Thr Ala Asp 

            420                 425                 430         





Asn Gln Thr Tyr Met Ala Val Gln Gly Ser Thr Ala Tyr Leu Leu Cys 

        435                 440                 445             





Lys Ala Phe Gly Ala Pro Val Pro Ser Val Gln Trp Leu Asp Glu Asp 

    450                 455                 460                 





Gly Thr Thr Val Leu Gln Asp Glu Arg Phe Phe Pro Tyr Ala Asn Gly 

465                 470                 475                 480 





Thr Leu Gly Ile Arg Asp Leu Gln Ala Asn Asp Thr Gly Arg Tyr Phe 

                485                 490                 495     





Cys Leu Ala Ala Asn Asp Gln Asn Asn Val Thr Ile Met Ala Asn Leu 

            500                 505                 510         





Lys Val Lys Asp Ala Thr Gln Ile Thr Gln Gly Pro Arg Ser Thr Ile 

        515                 520                 525             





Glu Lys Lys Gly Ser Arg Val Thr Phe Thr Cys Gln Ala Ser Phe Asp 

    530                 535                 540                 





Pro Ser Leu Gln Pro Ser Ile Thr Trp Arg Gly Asp Gly Arg Asp Leu 

545                 550                 555                 560 





Gln Glu Leu Gly Asp Ser Asp Lys Tyr Phe Ile Glu Asp Gly Arg Leu 

                565                 570                 575     





Val Ile His Ser Leu Asp Tyr Ser Asp Gln Gly Asn Tyr Ser Cys Val 

            580                 585                 590         





Ala Ser Thr Glu Leu Asp Val Val Glu Ser Arg Ala Gln Leu Leu Val 

        595                 600                 605             





Val Gly Ser Pro Gly Pro Val Pro Arg Leu Val Leu Ser Asp Leu His 

    610                 615                 620                 





Leu Leu Thr Gln Ser Gln Val Arg Val Ser Trp Ser Pro Ala Glu Asp 

625                 630                 635                 640 





His Asn Ala Pro Ile Glu Lys Tyr Asp Ile Glu Phe Glu Asp Lys Glu 

                645                 650                 655     





Met Ala Pro Glu Lys Trp Tyr Ser Leu Gly Lys Val Pro Gly Asn Gln 

            660                 665                 670         





Thr Ser Thr Thr Leu Lys Leu Ser Pro Tyr Val His Tyr Thr Phe Arg 

        675                 680                 685             





Val Thr Ala Ile Asn Lys Tyr Gly Pro Gly Glu Pro Ser Pro Val Ser 

    690                 695                 700                 





Glu Thr Val Val Thr Pro Glu Ala Ala Pro Glu Lys Asn Pro Val Asp 

705                 710                 715                 720 





Val Lys Gly Glu Gly Asn Glu Thr Thr Asn Met Val Ile Thr Trp Lys 

                725                 730                 735     





Pro Leu Arg Trp Met Asp Trp Asn Ala Pro Gln Val Gln Tyr Arg Val 

            740                 745                 750         





Gln Trp Arg Pro Gln Gly Thr Arg Gly Pro Trp Gln Glu Gln Ile Val 

        755                 760                 765             





Ser Asp Pro Phe Leu Val Val Ser Asn Thr Ser Thr Phe Val Pro Tyr 

    770                 775                 780                 





Glu Ile Lys Val Gln Ala Val Asn Ser Gln Gly Lys Gly Pro Glu Pro 

785                 790                 795                 800 





Gln Val Thr Ile Gly Tyr Ser Gly Glu Asp Tyr Pro Gln Ala Ile Pro 

                805                 810                 815     





Glu Leu Glu Gly Ile Glu Ile Leu Asn Ser Ser Ala Val Leu Val Lys 

            820                 825                 830         





Trp Arg Pro Val Asp Leu Ala Gln Val Lys Gly His Leu Arg Gly Tyr 

        835                 840                 845             





Asn Val Thr Tyr Trp Arg Glu Gly Ser Gln Arg Lys His Ser Lys Arg 

    850                 855                 860                 





His Ile His Lys Asp His Val Val Val Pro Ala Asn Thr Thr Ser Val 

865                 870                 875                 880 





Ile Leu Ser Gly Leu Arg Pro Tyr Ser Ser Tyr His Leu Glu Val Gln 

                885                 890                 895     





Ala Phe Asn Gly Arg Gly Ser Gly Pro Ala Ser Glu Phe Thr Phe Ser 

            900                 905                 910         





Thr Pro Glu Gly Val Pro Gly His Pro Glu Ala Leu His Leu Glu Cys 

        915                 920                 925             





Gln Ser Asn Thr Ser Leu Leu Leu Arg Trp Gln Pro Pro Leu Ser His 

    930                 935                 940                 





Asn Gly Val Leu Thr Gly Tyr Val Leu Ser Tyr His Pro Leu Asp Glu 

945                 950                 955                 960 





Gly Gly Lys Gly Gln Leu Ser Phe Asn Leu Arg Asp Pro Glu Leu Arg 

                965                 970                 975     





Thr His Asn Leu Thr Asp Leu Ser Pro His Leu Arg Tyr Arg Phe Gln 

            980                 985                 990         





Leu Gln Ala Thr Thr Lys Glu Gly  Pro Gly Glu Ala Ile  Val Arg Glu 

        995                 1000                 1005             





Gly Gly  Thr Met Ala Leu Ser  Gly Ile Ser Asp Phe  Gly Asn Ile 

    1010                 1015                 1020             





Ser Ala  Thr Ala Gly Glu Asn  Tyr Ser Val Val Ser  Trp Val Pro 

    1025                 1030                 1035             





Lys Glu  Gly Gln Cys Asn Phe  Arg Phe His Ile Leu  Phe Lys Ala 

    1040                 1045                 1050             





Leu Gly  Glu Glu Lys Gly Gly  Ala Ser Leu Ser Pro  Gln Tyr Val 

    1055                 1060                 1065             





Ser Tyr  Asn Gln Ser Ser Tyr  Thr Gln Trp Asp Leu  Gln Pro Asp 

    1070                 1075                 1080             





Thr Asp  Tyr Glu Ile His Leu  Phe Lys Glu Arg Met  Phe Arg His 

    1085                 1090                 1095             





Gln Met  Ala Val Lys Thr Asn  Gly Thr Gly Arg Val  Arg Leu Pro 

    1100                 1105                 1110             





Pro Ala  Gly Phe Ala Thr Glu  Gly Trp Phe Ile Gly  Phe Val Ser 

    1115                 1120                 1125             





Ala Ile  Ile Leu Leu Leu Leu  Val Leu Leu Ile Leu  Cys Phe Ile 

    1130                 1135                 1140             





Lys Arg  Ser Lys Gly Gly Lys  Tyr Ser Val Lys Asp  Lys Glu Asp 

    1145                 1150                 1155             





Thr Gln  Val Asp Ser Glu Ala  Arg Pro Met Lys Asp  Glu Thr Phe 

    1160                 1165                 1170             





Gly Glu  Tyr Arg Ser Leu Glu  Ser Asp Asn Glu Glu  Lys Ala Phe 

    1175                 1180                 1185             





Gly Ser  Ser Gln Pro Ser Leu  Asn Gly Asp Ile Lys  Pro Leu Gly 

    1190                 1195                 1200             





Ser Asp  Asp Ser Leu Ala Asp  Tyr Gly Gly Ser Val  Asp Val Gln 

    1205                 1210                 1215             





Phe Asn  Glu Asp Gly Ser Phe  Ile Gly Gln Tyr Ser  Gly Lys Lys 

    1220                 1225                 1230             





Glu Lys  Glu Ala Ala Gly Gly  Asn Asp Ser Ser Gly  Ala Thr Ser 

    1235                 1240                 1245             





Pro Ile  Asn Pro Ala Val Ala  Leu Glu 

    1250                 1255         





<210>  194

<211>  1248

<212>  PRT

<213>  Homo sapiens



<400>  194



Met Val Val Ala Leu Arg Tyr Val Trp Pro Leu Leu Leu Cys Ser Pro 

1               5                   10                  15      





Cys Leu Leu Ile Gln Ile Pro Glu Glu Leu Met Glu Pro Pro Val Ile 

            20                  25                  30          





Thr Glu Gln Ser Pro Arg Arg Leu Val Val Phe Pro Thr Asp Asp Ile 

        35                  40                  45              





Ser Leu Lys Cys Glu Ala Ser Gly Lys Pro Glu Val Gln Phe Arg Trp 

    50                  55                  60                  





Thr Arg Asp Gly Val His Phe Lys Pro Lys Glu Glu Leu Gly Val Thr 

65                  70                  75                  80  





Val Tyr Gln Ser Pro His Ser Gly Ser Phe Thr Ile Thr Gly Asn Asn 

                85                  90                  95      





Ser Asn Phe Ala Gln Arg Phe Gln Gly Ile Tyr Arg Cys Phe Ala Ser 

            100                 105                 110         





Asn Lys Leu Gly Thr Ala Met Ser His Glu Ile Arg Leu Met Ala Glu 

        115                 120                 125             





Gly Ala Pro Lys Trp Pro Lys Glu Thr Val Lys Pro Val Glu Val Glu 

    130                 135                 140                 





Glu Gly Glu Ser Val Val Leu Pro Cys Asn Pro Pro Pro Ser Ala Glu 

145                 150                 155                 160 





Pro Leu Arg Ile Tyr Trp Met Asn Ser Lys Ile Leu His Ile Lys Gln 

                165                 170                 175     





Asp Glu Arg Val Thr Met Gly Gln Asn Gly Asn Leu Tyr Phe Ala Asn 

            180                 185                 190         





Val Leu Thr Ser Asp Asn His Ser Asp Tyr Ile Cys His Ala His Phe 

        195                 200                 205             





Pro Gly Thr Arg Thr Ile Ile Gln Lys Glu Pro Ile Asp Leu Arg Val 

    210                 215                 220                 





Lys Ala Thr Asn Ser Met Ile Asp Arg Lys Pro Arg Leu Leu Phe Pro 

225                 230                 235                 240 





Thr Asn Ser Ser Ser His Leu Val Ala Leu Gln Gly Gln Pro Leu Val 

                245                 250                 255     





Leu Glu Cys Ile Ala Glu Gly Phe Pro Thr Pro Thr Ile Lys Trp Leu 

            260                 265                 270         





Arg Pro Ser Gly Pro Met Pro Ala Asp Arg Val Thr Tyr Gln Asn His 

        275                 280                 285             





Asn Lys Thr Leu Gln Leu Leu Lys Val Gly Glu Glu Asp Asp Gly Glu 

    290                 295                 300                 





Tyr Arg Cys Leu Ala Glu Asn Ser Leu Gly Ser Ala Arg His Ala Tyr 

305                 310                 315                 320 





Tyr Val Thr Val Glu Ala Ala Pro Tyr Trp Leu His Lys Pro Gln Ser 

                325                 330                 335     





His Leu Tyr Gly Pro Gly Glu Thr Ala Arg Leu Asp Cys Gln Val Gln 

            340                 345                 350         





Gly Arg Pro Gln Pro Glu Val Thr Trp Arg Ile Asn Gly Ile Pro Val 

        355                 360                 365             





Glu Glu Leu Ala Lys Asp Gln Lys Tyr Arg Ile Gln Arg Gly Ala Leu 

    370                 375                 380                 





Ile Leu Ser Asn Val Gln Pro Ser Asp Thr Met Val Thr Gln Cys Glu 

385                 390                 395                 400 





Ala Arg Asn Arg His Gly Leu Leu Leu Ala Asn Ala Tyr Ile Tyr Val 

                405                 410                 415     





Val Gln Leu Pro Ala Lys Ile Leu Thr Ala Asp Asn Gln Thr Tyr Met 

            420                 425                 430         





Ala Val Gln Gly Ser Thr Ala Tyr Leu Leu Cys Lys Ala Phe Gly Ala 

        435                 440                 445             





Pro Val Pro Ser Val Gln Trp Leu Asp Glu Asp Gly Thr Thr Val Leu 

    450                 455                 460                 





Gln Asp Glu Arg Phe Phe Pro Tyr Ala Asn Gly Thr Leu Gly Ile Arg 

465                 470                 475                 480 





Asp Leu Gln Ala Asn Asp Thr Gly Arg Tyr Phe Cys Leu Ala Ala Asn 

                485                 490                 495     





Asp Gln Asn Asn Val Thr Ile Met Ala Asn Leu Lys Val Lys Asp Ala 

            500                 505                 510         





Thr Gln Ile Thr Gln Gly Pro Arg Ser Thr Ile Glu Lys Lys Gly Ser 

        515                 520                 525             





Arg Val Thr Phe Thr Cys Gln Ala Ser Phe Asp Pro Ser Leu Gln Pro 

    530                 535                 540                 





Ser Ile Thr Trp Arg Gly Asp Gly Arg Asp Leu Gln Glu Leu Gly Asp 

545                 550                 555                 560 





Ser Asp Lys Tyr Phe Ile Glu Asp Gly Arg Leu Val Ile His Ser Leu 

                565                 570                 575     





Asp Tyr Ser Asp Gln Gly Asn Tyr Ser Cys Val Ala Ser Thr Glu Leu 

            580                 585                 590         





Asp Val Val Glu Ser Arg Ala Gln Leu Leu Val Val Gly Ser Pro Gly 

        595                 600                 605             





Pro Val Pro Arg Leu Val Leu Ser Asp Leu His Leu Leu Thr Gln Ser 

    610                 615                 620                 





Gln Val Arg Val Ser Trp Ser Pro Ala Glu Asp His Asn Ala Pro Ile 

625                 630                 635                 640 





Glu Lys Tyr Asp Ile Glu Phe Glu Asp Lys Glu Met Ala Pro Glu Lys 

                645                 650                 655     





Trp Tyr Ser Leu Gly Lys Val Pro Gly Asn Gln Thr Ser Thr Thr Leu 

            660                 665                 670         





Lys Leu Ser Pro Tyr Val His Tyr Thr Phe Arg Val Thr Ala Ile Asn 

        675                 680                 685             





Lys Tyr Gly Pro Gly Glu Pro Ser Pro Val Ser Glu Thr Val Val Thr 

    690                 695                 700                 





Pro Glu Ala Ala Pro Glu Lys Asn Pro Val Asp Val Lys Gly Glu Gly 

705                 710                 715                 720 





Asn Glu Thr Thr Asn Met Val Ile Thr Trp Lys Pro Leu Arg Trp Met 

                725                 730                 735     





Asp Trp Asn Ala Pro Gln Val Gln Tyr Arg Val Gln Trp Arg Pro Gln 

            740                 745                 750         





Gly Thr Arg Gly Pro Trp Gln Glu Gln Ile Val Ser Asp Pro Phe Leu 

        755                 760                 765             





Val Val Ser Asn Thr Ser Thr Phe Val Pro Tyr Glu Ile Lys Val Gln 

    770                 775                 780                 





Ala Val Asn Ser Gln Gly Lys Gly Pro Glu Pro Gln Val Thr Ile Gly 

785                 790                 795                 800 





Tyr Ser Gly Glu Asp Tyr Pro Gln Ala Ile Pro Glu Leu Glu Gly Ile 

                805                 810                 815     





Glu Ile Leu Asn Ser Ser Ala Val Leu Val Lys Trp Arg Pro Val Asp 

            820                 825                 830         





Leu Ala Gln Val Lys Gly His Leu Arg Gly Tyr Asn Val Thr Tyr Trp 

        835                 840                 845             





Arg Glu Gly Ser Gln Arg Lys His Ser Lys Arg His Ile His Lys Asp 

    850                 855                 860                 





His Val Val Val Pro Ala Asn Thr Thr Ser Val Ile Leu Ser Gly Leu 

865                 870                 875                 880 





Arg Pro Tyr Ser Ser Tyr His Leu Glu Val Gln Ala Phe Asn Gly Arg 

                885                 890                 895     





Gly Ser Gly Pro Ala Ser Glu Phe Thr Phe Ser Thr Pro Glu Gly Val 

            900                 905                 910         





Pro Gly His Pro Glu Ala Leu His Leu Glu Cys Gln Ser Asn Thr Ser 

        915                 920                 925             





Leu Leu Leu Arg Trp Gln Pro Pro Leu Ser His Asn Gly Val Leu Thr 

    930                 935                 940                 





Gly Tyr Val Leu Ser Tyr His Pro Leu Asp Glu Gly Gly Lys Gly Gln 

945                 950                 955                 960 





Leu Ser Phe Asn Leu Arg Asp Pro Glu Leu Arg Thr His Asn Leu Thr 

                965                 970                 975     





Asp Leu Ser Pro His Leu Arg Tyr Arg Phe Gln Leu Gln Ala Thr Thr 

            980                 985                 990         





Lys Glu Gly Pro Gly Glu Ala Ile  Val Arg Glu Gly Gly  Thr Met Ala 

        995                 1000                 1005             





Leu Ser  Gly Ile Ser Asp Phe  Gly Asn Ile Ser Ala  Thr Ala Gly 

    1010                 1015                 1020             





Glu Asn  Tyr Ser Val Val Ser  Trp Val Pro Lys Glu  Gly Gln Cys 

    1025                 1030                 1035             





Asn Phe  Arg Phe His Ile Leu  Phe Lys Ala Leu Gly  Glu Glu Lys 

    1040                 1045                 1050             





Gly Gly  Ala Ser Leu Ser Pro  Gln Tyr Val Ser Tyr  Asn Gln Ser 

    1055                 1060                 1065             





Ser Tyr  Thr Gln Trp Asp Leu  Gln Pro Asp Thr Asp  Tyr Glu Ile 

    1070                 1075                 1080             





His Leu  Phe Lys Glu Arg Met  Phe Arg His Gln Met  Ala Val Lys 

    1085                 1090                 1095             





Thr Asn  Gly Thr Gly Arg Val  Arg Leu Pro Pro Ala  Gly Phe Ala 

    1100                 1105                 1110             





Thr Glu  Gly Trp Phe Ile Gly  Phe Val Ser Ala Ile  Ile Leu Leu 

    1115                 1120                 1125             





Leu Leu  Val Leu Leu Ile Leu  Cys Phe Ile Lys Arg  Ser Lys Gly 

    1130                 1135                 1140             





Gly Lys  Tyr Ser Val Lys Asp  Lys Glu Asp Thr Gln  Val Asp Ser 

    1145                 1150                 1155             





Glu Ala  Arg Pro Met Lys Asp  Glu Thr Phe Gly Glu  Tyr Ser Asp 

    1160                 1165                 1170             





Asn Glu  Glu Lys Ala Phe Gly  Ser Ser Gln Pro Ser  Leu Asn Gly 

    1175                 1180                 1185             





Asp Ile  Lys Pro Leu Gly Ser  Asp Asp Ser Leu Ala  Asp Tyr Gly 

    1190                 1195                 1200             





Gly Ser  Val Asp Val Gln Phe  Asn Glu Asp Gly Ser  Phe Ile Gly 

    1205                 1210                 1215             





Gln Tyr  Ser Gly Lys Lys Glu  Lys Glu Ala Ala Gly  Gly Asn Asp 

    1220                 1225                 1230             





Ser Ser  Gly Ala Thr Ser Pro  Ile Asn Pro Ala Val  Ala Leu Glu 

    1235                 1240                 1245             





<210>  195

<211>  1257

<212>  PRT

<213>  Homo sapiens



<400>  195



Met Val Val Ala Leu Arg Tyr Val Trp Pro Leu Leu Leu Cys Ser Pro 

1               5                   10                  15      





Cys Leu Leu Ile Gln Ile Pro Glu Glu Tyr Glu Gly His His Val Met 

            20                  25                  30          





Glu Pro Pro Val Ile Thr Glu Gln Ser Pro Arg Arg Leu Val Val Phe 

        35                  40                  45              





Pro Thr Asp Asp Ile Ser Leu Lys Cys Glu Ala Ser Gly Lys Pro Glu 

    50                  55                  60                  





Val Gln Phe Arg Trp Thr Arg Asp Gly Val His Phe Lys Pro Lys Glu 

65                  70                  75                  80  





Glu Leu Gly Val Thr Val Tyr Gln Ser Pro His Ser Gly Ser Phe Thr 

                85                  90                  95      





Ile Thr Gly Asn Asn Ser Asn Phe Ala Gln Arg Phe Gln Gly Ile Tyr 

            100                 105                 110         





Arg Cys Phe Ala Ser Asn Lys Leu Gly Thr Ala Met Ser His Glu Ile 

        115                 120                 125             





Arg Leu Met Ala Glu Gly Ala Pro Lys Trp Pro Lys Glu Thr Val Lys 

    130                 135                 140                 





Pro Val Glu Val Glu Glu Gly Glu Ser Val Val Leu Pro Cys Asn Pro 

145                 150                 155                 160 





Pro Pro Ser Ala Glu Pro Leu Arg Ile Tyr Trp Met Asn Ser Lys Ile 

                165                 170                 175     





Leu His Ile Lys Gln Asp Glu Arg Val Thr Met Gly Gln Asn Gly Asn 

            180                 185                 190         





Leu Tyr Phe Ala Asn Val Leu Thr Ser Asp Asn His Ser Asp Tyr Ile 

        195                 200                 205             





Cys His Ala His Phe Pro Gly Thr Arg Thr Ile Ile Gln Lys Glu Pro 

    210                 215                 220                 





Ile Asp Leu Arg Val Lys Ala Thr Asn Ser Met Ile Asp Arg Lys Pro 

225                 230                 235                 240 





Arg Leu Leu Phe Pro Thr Asn Ser Ser Ser His Leu Val Ala Leu Gln 

                245                 250                 255     





Gly Gln Pro Leu Val Leu Glu Cys Ile Ala Glu Gly Phe Pro Thr Pro 

            260                 265                 270         





Thr Ile Lys Trp Leu Arg Pro Ser Gly Pro Met Pro Ala Asp Arg Val 

        275                 280                 285             





Thr Tyr Gln Asn His Asn Lys Thr Leu Gln Leu Leu Lys Val Gly Glu 

    290                 295                 300                 





Glu Asp Asp Gly Glu Tyr Arg Cys Leu Ala Glu Asn Ser Leu Gly Ser 

305                 310                 315                 320 





Ala Arg His Ala Tyr Tyr Val Thr Val Glu Ala Ala Pro Tyr Trp Leu 

                325                 330                 335     





His Lys Pro Gln Ser His Leu Tyr Gly Pro Gly Glu Thr Ala Arg Leu 

            340                 345                 350         





Asp Cys Gln Val Gln Gly Arg Pro Gln Pro Glu Val Thr Trp Arg Ile 

        355                 360                 365             





Asn Gly Ile Pro Val Glu Glu Leu Ala Lys Asp Gln Lys Tyr Arg Ile 

    370                 375                 380                 





Gln Arg Gly Ala Leu Ile Leu Ser Asn Val Gln Pro Ser Asp Thr Met 

385                 390                 395                 400 





Val Thr Gln Cys Glu Ala Arg Asn Arg His Gly Leu Leu Leu Ala Asn 

                405                 410                 415     





Ala Tyr Ile Tyr Val Val Gln Leu Pro Ala Lys Ile Leu Thr Ala Asp 

            420                 425                 430         





Asn Gln Thr Tyr Met Ala Val Gln Gly Ser Thr Ala Tyr Leu Leu Cys 

        435                 440                 445             





Lys Ala Phe Gly Ala Pro Val Pro Ser Val Gln Trp Leu Asp Glu Asp 

    450                 455                 460                 





Gly Thr Thr Val Leu Gln Asp Glu Arg Phe Phe Pro Tyr Ala Asn Gly 

465                 470                 475                 480 





Thr Leu Gly Ile Arg Asp Leu Gln Ala Asn Asp Thr Gly Arg Tyr Phe 

                485                 490                 495     





Cys Leu Ala Ala Asn Asp Gln Asn Asn Val Thr Ile Met Ala Asn Leu 

            500                 505                 510         





Lys Val Lys Asp Ala Thr Gln Ile Thr Gln Gly Pro Arg Ser Thr Ile 

        515                 520                 525             





Glu Lys Lys Gly Ser Arg Val Thr Phe Thr Cys Gln Ala Ser Phe Asp 

    530                 535                 540                 





Pro Ser Leu Gln Pro Ser Ile Thr Trp Arg Gly Asp Gly Arg Asp Leu 

545                 550                 555                 560 





Gln Glu Leu Gly Asp Ser Asp Lys Tyr Phe Ile Glu Asp Gly Arg Leu 

                565                 570                 575     





Val Ile His Ser Leu Asp Tyr Ser Asp Gln Gly Asn Tyr Ser Cys Val 

            580                 585                 590         





Ala Ser Thr Glu Leu Asp Val Val Glu Ser Arg Ala Gln Leu Leu Val 

        595                 600                 605             





Val Gly Ser Pro Gly Pro Val Pro Arg Leu Val Leu Ser Asp Leu His 

    610                 615                 620                 





Leu Leu Thr Gln Ser Gln Val Arg Val Ser Trp Ser Pro Ala Glu Asp 

625                 630                 635                 640 





His Asn Ala Pro Ile Glu Lys Tyr Asp Ile Glu Phe Glu Asp Lys Glu 

                645                 650                 655     





Met Ala Pro Glu Lys Trp Tyr Ser Leu Gly Lys Val Pro Gly Asn Gln 

            660                 665                 670         





Thr Ser Thr Thr Leu Lys Leu Ser Pro Tyr Val His Tyr Thr Phe Arg 

        675                 680                 685             





Val Thr Ala Ile Asn Lys Tyr Gly Pro Gly Glu Pro Ser Pro Val Ser 

    690                 695                 700                 





Glu Thr Val Val Thr Pro Glu Ala Ala Pro Glu Lys Asn Pro Val Asp 

705                 710                 715                 720 





Val Lys Gly Glu Gly Asn Glu Thr Thr Asn Met Val Ile Thr Trp Lys 

                725                 730                 735     





Pro Leu Arg Trp Met Asp Trp Asn Ala Pro Gln Val Gln Tyr Arg Val 

            740                 745                 750         





Gln Trp Arg Pro Gln Gly Thr Arg Gly Pro Trp Gln Glu Gln Ile Val 

        755                 760                 765             





Ser Asp Pro Phe Leu Val Val Ser Asn Thr Ser Thr Phe Val Pro Tyr 

    770                 775                 780                 





Glu Ile Lys Val Gln Ala Val Asn Ser Gln Gly Lys Gly Pro Glu Pro 

785                 790                 795                 800 





Gln Val Thr Ile Gly Tyr Ser Gly Glu Asp Tyr Pro Gln Ala Ile Pro 

                805                 810                 815     





Glu Leu Glu Gly Ile Glu Ile Leu Asn Ser Ser Ala Val Leu Val Lys 

            820                 825                 830         





Trp Arg Pro Val Asp Leu Ala Gln Val Lys Gly His Leu Arg Gly Tyr 

        835                 840                 845             





Asn Val Thr Tyr Trp Arg Glu Gly Ser Gln Arg Lys His Ser Lys Arg 

    850                 855                 860                 





His Ile His Lys Asp His Val Val Val Pro Ala Asn Thr Thr Ser Val 

865                 870                 875                 880 





Ile Leu Ser Gly Leu Arg Pro Tyr Ser Ser Tyr His Leu Glu Val Gln 

                885                 890                 895     





Ala Phe Asn Gly Arg Gly Ser Gly Pro Ala Ser Glu Phe Thr Phe Ser 

            900                 905                 910         





Thr Pro Glu Gly Val Pro Gly His Pro Glu Ala Leu His Leu Glu Cys 

        915                 920                 925             





Gln Ser Asn Thr Ser Leu Leu Leu Arg Trp Gln Pro Pro Leu Ser His 

    930                 935                 940                 





Asn Gly Val Leu Thr Gly Tyr Val Leu Ser Tyr His Pro Leu Asp Glu 

945                 950                 955                 960 





Gly Gly Lys Gly Gln Leu Ser Phe Asn Leu Arg Asp Pro Glu Leu Arg 

                965                 970                 975     





Thr His Asn Leu Thr Asp Leu Ser Pro His Leu Arg Tyr Arg Phe Gln 

            980                 985                 990         





Leu Gln Ala Thr Thr Lys Glu Gly  Pro Gly Glu Ala Ile  Val Arg Glu 

        995                 1000                 1005             





Gly Gly  Thr Met Ala Leu Ser  Gly Ile Ser Asp Phe  Gly Asn Ile 

    1010                 1015                 1020             





Ser Ala  Thr Ala Gly Glu Asn  Tyr Ser Val Val Ser  Trp Val Pro 

    1025                 1030                 1035             





Lys Glu  Gly Gln Cys Asn Phe  Arg Phe His Ile Leu  Phe Lys Ala 

    1040                 1045                 1050             





Leu Gly  Glu Glu Lys Gly Gly  Ala Ser Leu Ser Pro  Gln Tyr Val 

    1055                 1060                 1065             





Ser Tyr  Asn Gln Ser Ser Tyr  Thr Gln Trp Asp Leu  Gln Pro Asp 

    1070                 1075                 1080             





Thr Asp  Tyr Glu Ile His Leu  Phe Lys Glu Arg Met  Phe Arg His 

    1085                 1090                 1095             





Gln Met  Ala Val Lys Thr Asn  Gly Thr Gly Arg Val  Arg Leu Pro 

    1100                 1105                 1110             





Pro Ala  Gly Phe Ala Thr Glu  Gly Trp Phe Ile Gly  Phe Val Ser 

    1115                 1120                 1125             





Ala Ile  Ile Leu Leu Leu Leu  Val Leu Leu Ile Leu  Cys Phe Ile 

    1130                 1135                 1140             





Lys Arg  Ser Lys Gly Gly Lys  Tyr Ser Val Lys Asp  Lys Glu Asp 

    1145                 1150                 1155             





Thr Gln  Val Asp Ser Glu Ala  Arg Pro Met Lys Asp  Glu Thr Phe 

    1160                 1165                 1170             





Gly Glu  Tyr Arg Ser Leu Glu  Ser Asp Asn Glu Glu  Lys Ala Phe 

    1175                 1180                 1185             





Gly Ser  Ser Gln Pro Ser Leu  Asn Gly Asp Ile Lys  Pro Leu Gly 

    1190                 1195                 1200             





Ser Asp  Asp Ser Leu Ala Asp  Tyr Gly Gly Ser Val  Asp Val Gln 

    1205                 1210                 1215             





Phe Asn  Glu Asp Gly Ser Phe  Ile Gly Gln Tyr Ser  Gly Lys Lys 

    1220                 1225                 1230             





Glu Lys  Glu Ala Ala Gly Gly  Asn Asp Ser Ser Gly  Ala Thr Ser 

    1235                 1240                 1245             





Pro Ile  Asn Pro Ala Val Ala  Leu Glu 

    1250                 1255         





<210>  196

<211>  1253

<212>  PRT

<213>  Homo sapiens



<400>  196



Met Val Val Ala Leu Arg Tyr Val Trp Pro Leu Leu Leu Cys Ser Pro 

1               5                   10                  15      





Cys Leu Leu Ile Gln Ile Pro Glu Glu Tyr Glu Gly His His Val Met 

            20                  25                  30          





Glu Pro Pro Val Ile Thr Glu Gln Ser Pro Arg Arg Leu Val Val Phe 

        35                  40                  45              





Pro Thr Asp Asp Ile Ser Leu Lys Cys Glu Ala Ser Gly Lys Pro Glu 

    50                  55                  60                  





Val Gln Phe Arg Trp Thr Arg Asp Gly Val His Phe Lys Pro Lys Glu 

65                  70                  75                  80  





Glu Leu Gly Val Thr Val Tyr Gln Ser Pro His Ser Gly Ser Phe Thr 

                85                  90                  95      





Ile Thr Gly Asn Asn Ser Asn Phe Ala Gln Arg Phe Gln Gly Ile Tyr 

            100                 105                 110         





Arg Cys Phe Ala Ser Asn Lys Leu Gly Thr Ala Met Ser His Glu Ile 

        115                 120                 125             





Arg Leu Met Ala Glu Gly Ala Pro Lys Trp Pro Lys Glu Thr Val Lys 

    130                 135                 140                 





Pro Val Glu Val Glu Glu Gly Glu Ser Val Val Leu Pro Cys Asn Pro 

145                 150                 155                 160 





Pro Pro Ser Ala Glu Pro Leu Arg Ile Tyr Trp Met Asn Ser Lys Ile 

                165                 170                 175     





Leu His Ile Lys Gln Asp Glu Arg Val Thr Met Gly Gln Asn Gly Asn 

            180                 185                 190         





Leu Tyr Phe Ala Asn Val Leu Thr Ser Asp Asn His Ser Asp Tyr Ile 

        195                 200                 205             





Cys His Ala His Phe Pro Gly Thr Arg Thr Ile Ile Gln Lys Glu Pro 

    210                 215                 220                 





Ile Asp Leu Arg Val Lys Ala Thr Asn Ser Met Ile Asp Arg Lys Pro 

225                 230                 235                 240 





Arg Leu Leu Phe Pro Thr Asn Ser Ser Ser His Leu Val Ala Leu Gln 

                245                 250                 255     





Gly Gln Pro Leu Val Leu Glu Cys Ile Ala Glu Gly Phe Pro Thr Pro 

            260                 265                 270         





Thr Ile Lys Trp Leu Arg Pro Ser Gly Pro Met Pro Ala Asp Arg Val 

        275                 280                 285             





Thr Tyr Gln Asn His Asn Lys Thr Leu Gln Leu Leu Lys Val Gly Glu 

    290                 295                 300                 





Glu Asp Asp Gly Glu Tyr Arg Cys Leu Ala Glu Asn Ser Leu Gly Ser 

305                 310                 315                 320 





Ala Arg His Ala Tyr Tyr Val Thr Val Glu Ala Ala Pro Tyr Trp Leu 

                325                 330                 335     





His Lys Pro Gln Ser His Leu Tyr Gly Pro Gly Glu Thr Ala Arg Leu 

            340                 345                 350         





Asp Cys Gln Val Gln Gly Arg Pro Gln Pro Glu Val Thr Trp Arg Ile 

        355                 360                 365             





Asn Gly Ile Pro Val Glu Glu Leu Ala Lys Asp Gln Lys Tyr Arg Ile 

    370                 375                 380                 





Gln Arg Gly Ala Leu Ile Leu Ser Asn Val Gln Pro Ser Asp Thr Met 

385                 390                 395                 400 





Val Thr Gln Cys Glu Ala Arg Asn Arg His Gly Leu Leu Leu Ala Asn 

                405                 410                 415     





Ala Tyr Ile Tyr Val Val Gln Leu Pro Ala Lys Ile Leu Thr Ala Asp 

            420                 425                 430         





Asn Gln Thr Tyr Met Ala Val Gln Gly Ser Thr Ala Tyr Leu Leu Cys 

        435                 440                 445             





Lys Ala Phe Gly Ala Pro Val Pro Ser Val Gln Trp Leu Asp Glu Asp 

    450                 455                 460                 





Gly Thr Thr Val Leu Gln Asp Glu Arg Phe Phe Pro Tyr Ala Asn Gly 

465                 470                 475                 480 





Thr Leu Gly Ile Arg Asp Leu Gln Ala Asn Asp Thr Gly Arg Tyr Phe 

                485                 490                 495     





Cys Leu Ala Ala Asn Asp Gln Asn Asn Val Thr Ile Met Ala Asn Leu 

            500                 505                 510         





Lys Val Lys Asp Ala Thr Gln Ile Thr Gln Gly Pro Arg Ser Thr Ile 

        515                 520                 525             





Glu Lys Lys Gly Ser Arg Val Thr Phe Thr Cys Gln Ala Ser Phe Asp 

    530                 535                 540                 





Pro Ser Leu Gln Pro Ser Ile Thr Trp Arg Gly Asp Gly Arg Asp Leu 

545                 550                 555                 560 





Gln Glu Leu Gly Asp Ser Asp Lys Tyr Phe Ile Glu Asp Gly Arg Leu 

                565                 570                 575     





Val Ile His Ser Leu Asp Tyr Ser Asp Gln Gly Asn Tyr Ser Cys Val 

            580                 585                 590         





Ala Ser Thr Glu Leu Asp Val Val Glu Ser Arg Ala Gln Leu Leu Val 

        595                 600                 605             





Val Gly Ser Pro Gly Pro Val Pro Arg Leu Val Leu Ser Asp Leu His 

    610                 615                 620                 





Leu Leu Thr Gln Ser Gln Val Arg Val Ser Trp Ser Pro Ala Glu Asp 

625                 630                 635                 640 





His Asn Ala Pro Ile Glu Lys Tyr Asp Ile Glu Phe Glu Asp Lys Glu 

                645                 650                 655     





Met Ala Pro Glu Lys Trp Tyr Ser Leu Gly Lys Val Pro Gly Asn Gln 

            660                 665                 670         





Thr Ser Thr Thr Leu Lys Leu Ser Pro Tyr Val His Tyr Thr Phe Arg 

        675                 680                 685             





Val Thr Ala Ile Asn Lys Tyr Gly Pro Gly Glu Pro Ser Pro Val Ser 

    690                 695                 700                 





Glu Thr Val Val Thr Pro Glu Ala Ala Pro Glu Lys Asn Pro Val Asp 

705                 710                 715                 720 





Val Lys Gly Glu Gly Asn Glu Thr Thr Asn Met Val Ile Thr Trp Lys 

                725                 730                 735     





Pro Leu Arg Trp Met Asp Trp Asn Ala Pro Gln Val Gln Tyr Arg Val 

            740                 745                 750         





Gln Trp Arg Pro Gln Gly Thr Arg Gly Pro Trp Gln Glu Gln Ile Val 

        755                 760                 765             





Ser Asp Pro Phe Leu Val Val Ser Asn Thr Ser Thr Phe Val Pro Tyr 

    770                 775                 780                 





Glu Ile Lys Val Gln Ala Val Asn Ser Gln Gly Lys Gly Pro Glu Pro 

785                 790                 795                 800 





Gln Val Thr Ile Gly Tyr Ser Gly Glu Asp Tyr Pro Gln Ala Ile Pro 

                805                 810                 815     





Glu Leu Glu Gly Ile Glu Ile Leu Asn Ser Ser Ala Val Leu Val Lys 

            820                 825                 830         





Trp Arg Pro Val Asp Leu Ala Gln Val Lys Gly His Leu Arg Gly Tyr 

        835                 840                 845             





Asn Val Thr Tyr Trp Arg Glu Gly Ser Gln Arg Lys His Ser Lys Arg 

    850                 855                 860                 





His Ile His Lys Asp His Val Val Val Pro Ala Asn Thr Thr Ser Val 

865                 870                 875                 880 





Ile Leu Ser Gly Leu Arg Pro Tyr Ser Ser Tyr His Leu Glu Val Gln 

                885                 890                 895     





Ala Phe Asn Gly Arg Gly Ser Gly Pro Ala Ser Glu Phe Thr Phe Ser 

            900                 905                 910         





Thr Pro Glu Gly Val Pro Gly His Pro Glu Ala Leu His Leu Glu Cys 

        915                 920                 925             





Gln Ser Asn Thr Ser Leu Leu Leu Arg Trp Gln Pro Pro Leu Ser His 

    930                 935                 940                 





Asn Gly Val Leu Thr Gly Tyr Val Leu Ser Tyr His Pro Leu Asp Glu 

945                 950                 955                 960 





Gly Gly Lys Gly Gln Leu Ser Phe Asn Leu Arg Asp Pro Glu Leu Arg 

                965                 970                 975     





Thr His Asn Leu Thr Asp Leu Ser Pro His Leu Arg Tyr Arg Phe Gln 

            980                 985                 990         





Leu Gln Ala Thr Thr Lys Glu Gly  Pro Gly Glu Ala Ile  Val Arg Glu 

        995                 1000                 1005             





Gly Gly  Thr Met Ala Leu Ser  Gly Ile Ser Asp Phe  Gly Asn Ile 

    1010                 1015                 1020             





Ser Ala  Thr Ala Gly Glu Asn  Tyr Ser Val Val Ser  Trp Val Pro 

    1025                 1030                 1035             





Lys Glu  Gly Gln Cys Asn Phe  Arg Phe His Ile Leu  Phe Lys Ala 

    1040                 1045                 1050             





Leu Gly  Glu Glu Lys Gly Gly  Ala Ser Leu Ser Pro  Gln Tyr Val 

    1055                 1060                 1065             





Ser Tyr  Asn Gln Ser Ser Tyr  Thr Gln Trp Asp Leu  Gln Pro Asp 

    1070                 1075                 1080             





Thr Asp  Tyr Glu Ile His Leu  Phe Lys Glu Arg Met  Phe Arg His 

    1085                 1090                 1095             





Gln Met  Ala Val Lys Thr Asn  Gly Thr Gly Arg Val  Arg Leu Pro 

    1100                 1105                 1110             





Pro Ala  Gly Phe Ala Thr Glu  Gly Trp Phe Ile Gly  Phe Val Ser 

    1115                 1120                 1125             





Ala Ile  Ile Leu Leu Leu Leu  Val Leu Leu Ile Leu  Cys Phe Ile 

    1130                 1135                 1140             





Lys Arg  Ser Lys Gly Gly Lys  Tyr Ser Val Lys Asp  Lys Glu Asp 

    1145                 1150                 1155             





Thr Gln  Val Asp Ser Glu Ala  Arg Pro Met Lys Asp  Glu Thr Phe 

    1160                 1165                 1170             





Gly Glu  Tyr Ser Asp Asn Glu  Glu Lys Ala Phe Gly  Ser Ser Gln 

    1175                 1180                 1185             





Pro Ser  Leu Asn Gly Asp Ile  Lys Pro Leu Gly Ser  Asp Asp Ser 

    1190                 1195                 1200             





Leu Ala  Asp Tyr Gly Gly Ser  Val Asp Val Gln Phe  Asn Glu Asp 

    1205                 1210                 1215             





Gly Ser  Phe Ile Gly Gln Tyr  Ser Gly Lys Lys Glu  Lys Glu Ala 

    1220                 1225                 1230             





Ala Gly  Gly Asn Asp Ser Ser  Gly Ala Thr Ser Pro  Ile Asn Pro 

    1235                 1240                 1245             





Ala Val  Ala Leu Glu 

    1250             





<210>  197

<211>  622

<212>  PRT

<213>  Homo sapiens



<400>  197



Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 

1               5                   10                  15      





Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 

            20                  25                  30          





Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 

        35                  40                  45              





Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 

    50                  55                  60                  





Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 

65                  70                  75                  80  





Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 

                85                  90                  95      





Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 

            100                 105                 110         





Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 

        115                 120                 125             





Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 

    130                 135                 140                 





Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 

145                 150                 155                 160 





Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 

                165                 170                 175     





Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 

            180                 185                 190         





Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 

        195                 200                 205             





Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg 

    210                 215                 220                 





Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp 

225                 230                 235                 240 





Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly 

                245                 250                 255     





Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg 

            260                 265                 270         





Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile 

        275                 280                 285             





Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser 

    290                 295                 300                 





Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys 

305                 310                 315                 320 





Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met 

                325                 330                 335     





Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu 

            340                 345                 350         





Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val 

        355                 360                 365             





Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile 

    370                 375                 380                 





Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu 

385                 390                 395                 400 





Val Asn Lys Gly His Glu Met Ser Pro Gln Val Ala Thr Leu Ile Asp 

                405                 410                 415     





Arg Phe Val Lys Gly Arg Gly Gln Leu Asp Lys Asp Thr Leu Asp Thr 

            420                 425                 430         





Leu Thr Ala Phe Tyr Pro Gly Tyr Leu Cys Ser Leu Ser Pro Glu Glu 

        435                 440                 445             





Leu Ser Ser Val Pro Pro Ser Ser Ile Trp Ala Val Arg Pro Gln Asp 

    450                 455                 460                 





Leu Asp Thr Cys Asp Pro Arg Gln Leu Asp Val Leu Tyr Pro Lys Ala 

465                 470                 475                 480 





Arg Leu Ala Phe Gln Asn Met Asn Gly Ser Glu Tyr Phe Val Lys Ile 

                485                 490                 495     





Gln Ser Phe Leu Gly Gly Ala Pro Thr Glu Asp Leu Lys Ala Leu Ser 

            500                 505                 510         





Gln Gln Asn Val Ser Met Asp Leu Ala Thr Phe Met Lys Leu Arg Thr 

        515                 520                 525             





Asp Ala Val Leu Pro Leu Thr Val Ala Glu Val Gln Lys Leu Leu Gly 

    530                 535                 540                 





Pro His Val Glu Gly Leu Lys Ala Glu Glu Arg His Arg Pro Val Arg 

545                 550                 555                 560 





Asp Trp Ile Leu Arg Gln Arg Gln Asp Asp Leu Asp Thr Leu Gly Leu 

                565                 570                 575     





Gly Leu Gln Gly Gly Ile Pro Asn Gly Tyr Leu Val Leu Asp Leu Ser 

            580                 585                 590         





Met Gln Glu Ala Leu Ser Gly Thr Pro Cys Leu Leu Gly Pro Gly Pro 

        595                 600                 605             





Val Leu Thr Val Leu Ala Leu Leu Leu Ala Ser Thr Leu Ala 

    610                 615                 620         





<210>  198

<211>  622

<212>  PRT

<213>  Homo sapiens



<400>  198



Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 

1               5                   10                  15      





Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 

            20                  25                  30          





Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 

        35                  40                  45              





Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 

    50                  55                  60                  





Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 

65                  70                  75                  80  





Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 

                85                  90                  95      





Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 

            100                 105                 110         





Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 

        115                 120                 125             





Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 

    130                 135                 140                 





Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 

145                 150                 155                 160 





Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 

                165                 170                 175     





Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 

            180                 185                 190         





Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 

        195                 200                 205             





Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg 

    210                 215                 220                 





Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp 

225                 230                 235                 240 





Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly 

                245                 250                 255     





Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg 

            260                 265                 270         





Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile 

        275                 280                 285             





Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser 

    290                 295                 300                 





Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys 

305                 310                 315                 320 





Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met 

                325                 330                 335     





Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu 

            340                 345                 350         





Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val 

        355                 360                 365             





Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile 

    370                 375                 380                 





Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu 

385                 390                 395                 400 





Val Asn Lys Gly His Glu Met Ser Pro Gln Val Ala Thr Leu Ile Asp 

                405                 410                 415     





Arg Phe Val Lys Gly Arg Gly Gln Leu Asp Lys Asp Thr Leu Asp Thr 

            420                 425                 430         





Leu Thr Ala Phe Tyr Pro Gly Tyr Leu Cys Ser Leu Ser Pro Glu Glu 

        435                 440                 445             





Leu Ser Ser Val Pro Pro Ser Ser Ile Trp Ala Val Arg Pro Gln Asp 

    450                 455                 460                 





Leu Asp Thr Cys Asp Pro Arg Gln Leu Asp Val Leu Tyr Pro Lys Ala 

465                 470                 475                 480 





Arg Leu Ala Phe Gln Asn Met Asn Gly Ser Glu Tyr Phe Val Lys Ile 

                485                 490                 495     





Gln Ser Phe Leu Gly Gly Ala Pro Thr Glu Asp Leu Lys Ala Leu Ser 

            500                 505                 510         





Gln Gln Asn Val Ser Met Asp Leu Ala Thr Phe Met Lys Leu Arg Thr 

        515                 520                 525             





Asp Ala Val Leu Pro Leu Thr Val Ala Glu Val Gln Lys Leu Leu Gly 

    530                 535                 540                 





Pro His Val Glu Gly Leu Lys Ala Glu Glu Arg His Arg Pro Val Arg 

545                 550                 555                 560 





Asp Trp Ile Leu Arg Gln Arg Gln Asp Asp Leu Asp Thr Leu Gly Leu 

                565                 570                 575     





Gly Leu Gln Gly Gly Ile Pro Asn Gly Tyr Leu Val Leu Asp Leu Ser 

            580                 585                 590         





Met Gln Glu Ala Leu Ser Gly Thr Pro Cys Leu Leu Gly Pro Gly Pro 

        595                 600                 605             





Val Leu Thr Val Leu Ala Leu Leu Leu Ala Ser Thr Leu Ala 

    610                 615                 620         





<210>  199

<211>  630

<212>  PRT

<213>  Homo sapiens



<400>  199



Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 

1               5                   10                  15      





Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 

            20                  25                  30          





Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 

        35                  40                  45              





Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 

    50                  55                  60                  





Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 

65                  70                  75                  80  





Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 

                85                  90                  95      





Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 

            100                 105                 110         





Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 

        115                 120                 125             





Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 

    130                 135                 140                 





Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 

145                 150                 155                 160 





Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 

                165                 170                 175     





Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 

            180                 185                 190         





Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 

        195                 200                 205             





Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg 

    210                 215                 220                 





Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp 

225                 230                 235                 240 





Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly 

                245                 250                 255     





Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg 

            260                 265                 270         





Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile 

        275                 280                 285             





Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser 

    290                 295                 300                 





Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys 

305                 310                 315                 320 





Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met 

                325                 330                 335     





Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu 

            340                 345                 350         





Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val 

        355                 360                 365             





Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile 

    370                 375                 380                 





Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu 

385                 390                 395                 400 





Val Asn Lys Gly His Glu Met Ser Pro Gln Ala Pro Arg Arg Pro Leu 

                405                 410                 415     





Pro Gln Val Ala Thr Leu Ile Asp Arg Phe Val Lys Gly Arg Gly Gln 

            420                 425                 430         





Leu Asp Lys Asp Thr Leu Asp Thr Leu Thr Ala Phe Tyr Pro Gly Tyr 

        435                 440                 445             





Leu Cys Ser Leu Ser Pro Glu Glu Leu Ser Ser Val Pro Pro Ser Ser 

    450                 455                 460                 





Ile Trp Ala Val Arg Pro Gln Asp Leu Asp Thr Cys Asp Pro Arg Gln 

465                 470                 475                 480 





Leu Asp Val Leu Tyr Pro Lys Ala Arg Leu Ala Phe Gln Asn Met Asn 

                485                 490                 495     





Gly Ser Glu Tyr Phe Val Lys Ile Gln Ser Phe Leu Gly Gly Ala Pro 

            500                 505                 510         





Thr Glu Asp Leu Lys Ala Leu Ser Gln Gln Asn Val Ser Met Asp Leu 

        515                 520                 525             





Ala Thr Phe Met Lys Leu Arg Thr Asp Ala Val Leu Pro Leu Thr Val 

    530                 535                 540                 





Ala Glu Val Gln Lys Leu Leu Gly Pro His Val Glu Gly Leu Lys Ala 

545                 550                 555                 560 





Glu Glu Arg His Arg Pro Val Arg Asp Trp Ile Leu Arg Gln Arg Gln 

                565                 570                 575     





Asp Asp Leu Asp Thr Leu Gly Leu Gly Leu Gln Gly Gly Ile Pro Asn 

            580                 585                 590         





Gly Tyr Leu Val Leu Asp Leu Ser Met Gln Glu Ala Leu Ser Gly Thr 

        595                 600                 605             





Pro Cys Leu Leu Gly Pro Gly Pro Val Leu Thr Val Leu Ala Leu Leu 

    610                 615                 620                 





Leu Ala Ser Thr Leu Ala 

625                 630 





<210>  200

<211>  264

<212>  PRT

<213>  Homo sapiens



<400>  200



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 

            20                  25                  30          





Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 

        35                  40                  45              





Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn 

    50                  55                  60                  





Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg 

65                  70                  75                  80  





Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu 

                85                  90                  95      





Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu 

            100                 105                 110         





Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr 

        115                 120                 125             





Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr 

    130                 135                 140                 





Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln 

145                 150                 155                 160 





Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val 

                165                 170                 175     





Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val 

            180                 185                 190         





Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala 

        195                 200                 205             





Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His 

    210                 215                 220                 





Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys 

225                 230                 235                 240 





Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala 

                245                 250                 255     





Val Ala Ala Thr Ser Ala Asn Leu 

            260                 





<210>  201

<211>  255

<212>  PRT

<213>  Homo sapiens



<400>  201



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 

            20                  25                  30          





Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 

        35                  40                  45              





Thr Glu Lys Asn Ala Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp 

    50                  55                  60                  





Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu Gln Ile 

65                  70                  75                  80  





Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro 

                85                  90                  95      





Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile 

            100                 105                 110         





Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala 

        115                 120                 125             





Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val 

    130                 135                 140                 





Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly 

145                 150                 155                 160 





Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val 

                165                 170                 175     





Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly 

            180                 185                 190         





Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu 

        195                 200                 205             





Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr 

    210                 215                 220                 





Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser 

225                 230                 235                 240 





Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 

                245                 250                 255 





<210>  202

<211>  203

<212>  PRT

<213>  Homo sapiens



<400>  202



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 

            20                  25                  30          





Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 

        35                  40                  45              





Thr Glu Lys Asn Ala Ile Pro Ala Pro Thr Thr Thr Lys Ser Cys Arg 

    50                  55                  60                  





Glu Thr Phe Leu Lys Cys Phe Cys Arg Phe Ile Asn Lys Gly Val Phe 

65                  70                  75                  80  





Trp Ala Ser Pro Ile Leu Ser Ser Val Ser Asp Val Pro Phe Pro Phe 

                85                  90                  95      





Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu 

            100                 105                 110         





Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala 

        115                 120                 125             





Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile 

    130                 135                 140                 





Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr 

145                 150                 155                 160 





His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro 

                165                 170                 175     





Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr 

            180                 185                 190         





Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 

        195                 200             





<210>  203

<211>  150

<212>  PRT

<213>  Homo sapiens



<400>  203



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 

            20                  25                  30          





Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 

        35                  40                  45              





Thr Glu Lys Asn Ala Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp 

    50                  55                  60                  





Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Ala Val Cys Gln 

65                  70                  75                  80  





Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp 

                85                  90                  95      





Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg 

            100                 105                 110         





Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser 

        115                 120                 125             





Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala 

    130                 135                 140                 





Ala Thr Ser Ala Asn Leu 

145                 150 





<210>  204

<211>  159

<212>  PRT

<213>  Homo sapiens



<400>  204



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 

            20                  25                  30          





Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 

        35                  40                  45              





Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn 

    50                  55                  60                  





Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg 

65                  70                  75                  80  





Asp Ile Ser Glu Met Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly 

                85                  90                  95      





Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu 

            100                 105                 110         





Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr 

        115                 120                 125             





Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser 

    130                 135                 140                 





Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 

145                 150                 155                 





<210>  205

<211>  158

<212>  PRT

<213>  Homo sapiens



<400>  205



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 

            20                  25                  30          





Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 

        35                  40                  45              





Thr Glu Lys Asn Ala Ile Pro Ala Pro Thr Thr Thr Lys Ser Cys Arg 

    50                  55                  60                  





Glu Thr Phe Leu Lys Cys Phe Cys Arg Phe Ile Asn Lys Gly Val Phe 

65                  70                  75                  80  





Trp Ala Ser Pro Ile Leu Ser Ser Val Trp Gly Trp Gly Ala Arg Leu 

                85                  90                  95      





Gly His Arg Ala Ala Gly Ala Gly Leu Cys Ser Gly Cys Ala Gly His 

            100                 105                 110         





Cys Leu Ser His Cys Leu Gly Cys Leu Ser Val Pro Pro Lys Glu Leu 

        115                 120                 125             





Arg Ala Ala Gly His Leu Ser Ser Pro Gly Tyr Leu Pro Ser Tyr Glu 

    130                 135                 140                 





Arg Val Pro His Leu Pro His Pro Trp Ala Leu Cys Ala Pro 

145                 150                 155             





<210>  206

<211>  475

<212>  PRT

<213>  Homo sapiens



<400>  206



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 

            20                  25                  30          





Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 

        35                  40                  45              





Thr Glu Lys Asn Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His 

    50                  55                  60                  





Ser Pro Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu 

65                  70                  75                  80  





Ala Pro Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln 

                85                  90                  95      





Asp Val Thr Ser Val Pro Val Thr Arg Pro Ala Leu Gly Ser Thr Thr 

            100                 105                 110         





Pro Pro Ala His Asp Val Thr Ser Ala Pro Asp Asn Lys Pro Ala Pro 

        115                 120                 125             





Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 

    130                 135                 140                 





Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 

145                 150                 155                 160 





Ala Pro Asp Asn Arg Pro Ala Leu Gly Ser Thr Ala Pro Pro Val His 

                165                 170                 175     





Asn Val Thr Ser Ala Ser Gly Ser Ala Ser Gly Ser Ala Ser Thr Leu 

            180                 185                 190         





Val His Asn Gly Thr Ser Ala Arg Ala Thr Thr Thr Pro Ala Ser Lys 

        195                 200                 205             





Ser Thr Pro Phe Ser Ile Pro Ser His His Ser Asp Thr Pro Thr Thr 

    210                 215                 220                 





Leu Ala Ser His Ser Thr Lys Thr Asp Ala Ser Ser Thr His His Ser 

225                 230                 235                 240 





Thr Val Pro Pro Leu Thr Ser Ser Asn His Ser Thr Ser Pro Gln Leu 

                245                 250                 255     





Ser Thr Gly Val Ser Phe Phe Phe Leu Ser Phe His Ile Ser Asn Leu 

            260                 265                 270         





Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu 

        275                 280                 285             





Leu Gln Arg Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly 

    290                 295                 300                 





Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val 

305                 310                 315                 320 





Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp 

                325                 330                 335     





Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr 

            340                 345                 350         





Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe 

        355                 360                 365             





Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu 

    370                 375                 380                 





Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala 

385                 390                 395                 400 





Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile 

                405                 410                 415     





Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr 

            420                 425                 430         





His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro 

        435                 440                 445             





Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr 

    450                 455                 460                 





Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 

465                 470                 475 





<210>  207

<211>  484

<212>  PRT

<213>  Homo sapiens



<400>  207



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 

            20                  25                  30          





Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 

        35                  40                  45              





Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Val Ser 

    50                  55                  60                  





Met Thr Ser Ser Val Leu Ser Ser His Ser Pro Gly Ser Gly Ser Ser 

65                  70                  75                  80  





Thr Thr Gln Gly Gln Asp Val Thr Leu Ala Pro Ala Thr Glu Pro Ala 

                85                  90                  95      





Ser Gly Ser Ala Ala Thr Trp Gly Gln Asp Val Thr Ser Val Pro Val 

            100                 105                 110         





Thr Arg Pro Ala Leu Gly Ser Thr Thr Pro Pro Ala His Asp Val Thr 

        115                 120                 125             





Ser Ala Pro Asp Asn Lys Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 

    130                 135                 140                 





His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 

145                 150                 155                 160 





Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Asn Arg Pro Ala 

                165                 170                 175     





Leu Gly Ser Thr Ala Pro Pro Val His Asn Val Thr Ser Ala Ser Gly 

            180                 185                 190         





Ser Ala Ser Gly Ser Ala Ser Thr Leu Val His Asn Gly Thr Ser Ala 

        195                 200                 205             





Arg Ala Thr Thr Thr Pro Ala Ser Lys Ser Thr Pro Phe Ser Ile Pro 

    210                 215                 220                 





Ser His His Ser Asp Thr Pro Thr Thr Leu Ala Ser His Ser Thr Lys 

225                 230                 235                 240 





Thr Asp Ala Ser Ser Thr His His Ser Thr Val Pro Pro Leu Thr Ser 

                245                 250                 255     





Ser Asn His Ser Thr Ser Pro Gln Leu Ser Thr Gly Val Ser Phe Phe 

            260                 265                 270         





Phe Leu Ser Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu 

        275                 280                 285             





Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu 

    290                 295                 300                 





Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn 

305                 310                 315                 320 





Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe 

                325                 330                 335     





Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln 

            340                 345                 350         





Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val 

        355                 360                 365             





Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly 

    370                 375                 380                 





Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val 

385                 390                 395                 400 





Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg 

                405                 410                 415     





Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr 

            420                 425                 430         





His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val 

        435                 440                 445             





Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly 

    450                 455                 460                 





Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr 

465                 470                 475                 480 





Ser Ala Asn Leu 

                





<210>  208

<211>  282

<212>  PRT

<213>  Homo sapiens



<400>  208



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 

            20                  25                  30          





Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 

        35                  40                  45              





Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Leu Ser 

    50                  55                  60                  





Thr Gly Val Ser Phe Phe Phe Leu Ser Phe His Ile Ser Asn Leu Gln 

65                  70                  75                  80  





Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu 

                85                  90                  95      





Gln Arg Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly 

            100                 105                 110         





Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val 

        115                 120                 125             





Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val 

    130                 135                 140                 





Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn 

145                 150                 155                 160 





Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser 

                165                 170                 175     





Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val 

            180                 185                 190         





Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu 

        195                 200                 205             





Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe 

    210                 215                 220                 





Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His 

225                 230                 235                 240 





Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr 

                245                 250                 255     





Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn 

            260                 265                 270         





Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 

        275                 280         





<210>  209

<211>  219

<212>  PRT

<213>  Homo sapiens



<400>  209



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 

            20                  25                  30          





Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 

        35                  40                  45              





Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn 

    50                  55                  60                  





Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg 

65                  70                  75                  80  





Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu 

                85                  90                  95      





Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu 

            100                 105                 110         





Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr 

        115                 120                 125             





Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr 

    130                 135                 140                 





Ile Ser Asp Val Ser Val Trp Gly Trp Gly Ala Arg Leu Gly His Arg 

145                 150                 155                 160 





Ala Ala Gly Ala Gly Leu Cys Ser Gly Cys Ala Gly His Cys Leu Ser 

                165                 170                 175     





His Cys Leu Gly Cys Leu Ser Val Pro Pro Lys Glu Leu Arg Ala Ala 

            180                 185                 190         





Gly His Leu Ser Ser Pro Gly Tyr Leu Pro Ser Tyr Glu Arg Val Pro 

        195                 200                 205             





His Leu Pro His Pro Trp Ala Leu Cys Ala Pro 

    210                 215                 





<210>  210

<211>  238

<212>  PRT

<213>  Homo sapiens



<400>  210



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 

            20                  25                  30          





Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 

        35                  40                  45              





Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Ile Tyr 

    50                  55                  60                  





Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly 

65                  70                  75                  80  





Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn 

                85                  90                  95      





Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala 

            100                 105                 110         





Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro 

        115                 120                 125             





Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile 

    130                 135                 140                 





Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr 

145                 150                 155                 160 





Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln 

                165                 170                 175     





Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr 

            180                 185                 190         





Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp 

        195                 200                 205             





Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu 

    210                 215                 220                 





Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 

225                 230                 235             





<210>  211

<211>  217

<212>  PRT

<213>  Homo sapiens



<400>  211



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Gly Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser 

            20                  25                  30          





Val Pro Ser Ser Thr Glu Lys Asn Ala Ile Tyr Lys Gln Gly Gly Phe 

        35                  40                  45              





Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln 

    50                  55                  60                  





Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu 

65                  70                  75                  80  





Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu 

                85                  90                  95      





Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala 

            100                 105                 110         





Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu 

        115                 120                 125             





Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala 

    130                 135                 140                 





Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro 

145                 150                 155                 160 





Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr 

                165                 170                 175     





His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu 

            180                 185                 190         





Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro 

        195                 200                 205             





Ala Val Ala Ala Thr Ser Ala Asn Leu 

    210                 215         





<210>  212

<211>  241

<212>  PRT

<213>  Homo sapiens



<400>  212



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 

            20                  25                  30          





Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 

        35                  40                  45              





Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Leu 

    50                  55                  60                  





Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe 

65                  70                  75                  80  





Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly 

                85                  90                  95      





Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 

            100                 105                 110         





Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser 

        115                 120                 125             





Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly 

    130                 135                 140                 





Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala 

145                 150                 155                 160 





Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn 

                165                 170                 175     





Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met 

            180                 185                 190         





Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser 

        195                 200                 205             





Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly 

    210                 215                 220                 





Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn 

225                 230                 235                 240 





Leu 

    





<210>  213

<211>  239

<212>  PRT

<213>  Homo sapiens



<400>  213



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 

            20                  25                  30          





Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 

        35                  40                  45              





Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Ile Pro 

    50                  55                  60                  





Ala Pro Thr Thr Thr Lys Ser Cys Arg Glu Thr Phe Leu Lys Trp Pro 

65                  70                  75                  80  





Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile 

                85                  90                  95      





Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala 

            100                 105                 110         





Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val 

        115                 120                 125             





Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly 

    130                 135                 140                 





Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val 

145                 150                 155                 160 





Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly 

                165                 170                 175     





Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu 

            180                 185                 190         





Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr 

        195                 200                 205             





Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser 

    210                 215                 220                 





Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 

225                 230                 235                 





<210>  214

<211>  198

<212>  PRT

<213>  Homo sapiens



<400>  214



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 

            20                  25                  30          





Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 

        35                  40                  45              





Thr Glu Lys Asn Ala Leu Ser Thr Gly Val Ser Phe Phe Phe Leu Ser 

    50                  55                  60                  





Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser 

65                  70                  75                  80  





Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu 

                85                  90                  95      





Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe 

            100                 105                 110         





Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly 

        115                 120                 125             





Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 

    130                 135                 140                 





Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Gly Cys 

145                 150                 155                 160 





Leu Ser Val Pro Pro Lys Glu Leu Arg Ala Ala Gly His Leu Ser Ser 

                165                 170                 175     





Pro Gly Tyr Leu Pro Ser Tyr Glu Arg Val Pro His Leu Pro His Pro 

            180                 185                 190         





Trp Ala Leu Cys Ala Pro 

        195             





<210>  215

<211>  230

<212>  PRT

<213>  Homo sapiens



<400>  215



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 

            20                  25                  30          





Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 

        35                  40                  45              





Thr Glu Lys Asn Ala Ile Pro Ala Pro Thr Thr Thr Lys Ser Cys Arg 

    50                  55                  60                  





Glu Thr Phe Leu Lys Trp Pro Gly Ser Val Val Val Gln Leu Thr Leu 

65                  70                  75                  80  





Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe 

                85                  90                  95      





Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser 

            100                 105                 110         





Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly 

        115                 120                 125             





Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val 

    130                 135                 140                 





Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln 

145                 150                 155                 160 





Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp 

                165                 170                 175     





Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg 

            180                 185                 190         





Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser 

        195                 200                 205             





Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala 

    210                 215                 220                 





Ala Thr Ser Ala Asn Leu 

225                 230 





<210>  216

<211>  189

<212>  PRT

<213>  Homo sapiens



<400>  216



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 

            20                  25                  30          





Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 

        35                  40                  45              





Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn 

    50                  55                  60                  





Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg 

65                  70                  75                  80  





Asp Ile Ser Glu Met Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala 

                85                  90                  95      





Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu 

            100                 105                 110         





Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu 

        115                 120                 125             





Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro 

    130                 135                 140                 





Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg 

145                 150                 155                 160 





Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser 

                165                 170                 175     





Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 

            180                 185                 





<210>  217

<211>  212

<212>  PRT

<213>  Homo sapiens



<400>  217



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 

            20                  25                  30          





Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 

        35                  40                  45              





Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Ile Pro 

    50                  55                  60                  





Ala Pro Thr Thr Thr Lys Ser Cys Arg Glu Thr Phe Leu Lys Cys Phe 

65                  70                  75                  80  





Cys Arg Phe Ile Asn Lys Gly Val Phe Trp Ala Ser Pro Ile Leu Ser 

                85                  90                  95      





Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly 

            100                 105                 110         





Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val 

        115                 120                 125             





Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg 

    130                 135                 140                 





Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr 

145                 150                 155                 160 





His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val 

                165                 170                 175     





Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly 

            180                 185                 190         





Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr 

        195                 200                 205             





Ser Ala Asn Leu 

    210         





<210>  218

<211>  177

<212>  PRT

<213>  Homo sapiens



<400>  218



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 

            20                  25                  30          





Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 

        35                  40                  45              





Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Leu Ser 

    50                  55                  60                  





Thr Gly Val Ser Phe Phe Phe Leu Ser Phe His Ile Ser Asn Leu Gln 

65                  70                  75                  80  





Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu 

                85                  90                  95      





Gln Arg Asp Ile Ser Glu Met Ala Val Cys Gln Cys Arg Arg Lys Asn 

            100                 105                 110         





Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met 

        115                 120                 125             





Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser 

    130                 135                 140                 





Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly 

145                 150                 155                 160 





Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn 

                165                 170                 175     





Leu 

    





<210>  219

<211>  273

<212>  PRT

<213>  Homo sapiens



<400>  219



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 

            20                  25                  30          





Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 

        35                  40                  45              





Thr Glu Lys Asn Ala Leu Ser Thr Gly Val Ser Phe Phe Phe Leu Ser 

    50                  55                  60                  





Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser 

65                  70                  75                  80  





Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu 

                85                  90                  95      





Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe 

            100                 105                 110         





Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly 

        115                 120                 125             





Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 

    130                 135                 140                 





Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser 

145                 150                 155                 160 





Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly 

                165                 170                 175     





Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala 

            180                 185                 190         





Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn 

        195                 200                 205             





Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met 

    210                 215                 220                 





Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser 

225                 230                 235                 240 





Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly 

                245                 250                 255     





Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn 

            260                 265                 270         





Leu 

    





<210>  220

<211>  216

<212>  PRT

<213>  Homo sapiens



<400>  220



Met Gly Trp Ile Arg Gly Arg Arg Ser Arg His Ser Trp Glu Met Ser 

1               5                   10                  15      





Glu Phe His Asn Tyr Asn Leu Asp Leu Lys Lys Ser Asp Phe Ser Thr 

            20                  25                  30          





Arg Trp Gln Lys Gln Arg Cys Pro Val Val Lys Ser Lys Cys Arg Glu 

        35                  40                  45              





Asn Ala Ser Pro Phe Phe Phe Cys Cys Phe Ile Ala Val Ala Met Gly 

    50                  55                  60                  





Ile Arg Phe Ile Ile Met Val Thr Ile Trp Ser Ala Val Phe Leu Asn 

65                  70                  75                  80  





Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 

                85                  90                  95      





Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 

            100                 105                 110         





Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 

        115                 120                 125             





Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 

    130                 135                 140                 





Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile 

145                 150                 155                 160 





Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 

                165                 170                 175     





Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 

            180                 185                 190         





Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr 

        195                 200                 205             





Tyr Ile Cys Met Gln Arg Thr Val 

    210                 215     





<210>  221

<211>  420

<212>  PRT

<213>  Homo sapiens



<400>  221



Met Pro Gly Gly Cys Ser Arg Gly Pro Ala Ala Gly Asp Gly Arg Leu 

1               5                   10                  15      





Arg Leu Ala Arg Leu Ala Leu Val Leu Leu Gly Trp Val Ser Ser Ser 

            20                  25                  30          





Ser Pro Thr Ser Ser Ala Ser Ser Phe Ser Ser Ser Ala Pro Phe Leu 

        35                  40                  45              





Ala Ser Ala Val Ser Ala Gln Pro Pro Leu Pro Asp Gln Cys Pro Ala 

    50                  55                  60                  





Leu Cys Glu Cys Ser Glu Ala Ala Arg Thr Val Lys Cys Val Asn Arg 

65                  70                  75                  80  





Asn Leu Thr Glu Val Pro Thr Asp Leu Pro Ala Tyr Val Arg Asn Leu 

                85                  90                  95      





Phe Leu Thr Gly Asn Gln Leu Ala Val Leu Pro Ala Gly Ala Phe Ala 

            100                 105                 110         





Arg Arg Pro Pro Leu Ala Glu Leu Ala Ala Leu Asn Leu Ser Gly Ser 

        115                 120                 125             





Arg Leu Asp Glu Val Arg Ala Gly Ala Phe Glu His Leu Pro Ser Leu 

    130                 135                 140                 





Arg Gln Leu Asp Leu Ser His Asn Pro Leu Ala Asp Leu Ser Pro Phe 

145                 150                 155                 160 





Ala Phe Ser Gly Ser Asn Ala Ser Val Ser Ala Pro Ser Pro Leu Val 

                165                 170                 175     





Glu Leu Ile Leu Asn His Ile Val Pro Pro Glu Asp Glu Arg Gln Asn 

            180                 185                 190         





Arg Ser Phe Glu Gly Met Val Val Ala Ala Leu Leu Ala Gly Arg Ala 

        195                 200                 205             





Leu Gln Gly Leu Arg Arg Leu Glu Leu Ala Ser Asn His Phe Leu Tyr 

    210                 215                 220                 





Leu Pro Arg Asp Val Leu Ala Gln Leu Pro Ser Leu Arg His Leu Asp 

225                 230                 235                 240 





Leu Ser Asn Asn Ser Leu Val Ser Leu Thr Tyr Val Ser Phe Arg Asn 

                245                 250                 255     





Leu Thr His Leu Glu Ser Leu His Leu Glu Asp Asn Ala Leu Lys Val 

            260                 265                 270         





Leu His Asn Gly Thr Leu Ala Glu Leu Gln Gly Leu Pro His Ile Arg 

        275                 280                 285             





Val Phe Leu Asp Asn Asn Pro Trp Val Cys Asp Cys His Met Ala Asp 

    290                 295                 300                 





Met Val Thr Trp Leu Lys Glu Thr Glu Val Val Gln Gly Lys Asp Arg 

305                 310                 315                 320 





Leu Thr Cys Ala Tyr Pro Glu Lys Met Arg Asn Arg Val Leu Leu Glu 

                325                 330                 335     





Leu Asn Ser Ala Asp Leu Asp Cys Asp Pro Ile Leu Pro Pro Ser Leu 

            340                 345                 350         





Gln Thr Ser Tyr Val Phe Leu Gly Ile Val Leu Ala Leu Ile Gly Ala 

        355                 360                 365             





Ile Phe Leu Leu Val Leu Tyr Leu Asn Arg Lys Gly Ile Lys Lys Trp 

    370                 375                 380                 





Met His Asn Ile Arg Asp Ala Cys Arg Asp His Met Glu Gly Tyr His 

385                 390                 395                 400 





Tyr Arg Tyr Glu Ile Asn Ala Asp Pro Arg Leu Thr Asn Leu Ser Ser 

                405                 410                 415     





Asn Ser Asp Val 

            420 





<210>  222

<211>  420

<212>  PRT

<213>  Homo sapiens



<400>  222



Met Pro Gly Gly Cys Ser Arg Gly Pro Ala Ala Gly Asp Gly Arg Leu 

1               5                   10                  15      





Arg Leu Ala Arg Leu Ala Leu Val Leu Leu Gly Trp Val Ser Ser Ser 

            20                  25                  30          





Ser Pro Thr Ser Ser Ala Ser Ser Phe Ser Ser Ser Ala Pro Phe Leu 

        35                  40                  45              





Ala Ser Ala Val Ser Ala Gln Pro Pro Leu Pro Asp Gln Cys Pro Ala 

    50                  55                  60                  





Leu Cys Glu Cys Ser Glu Ala Ala Arg Thr Val Lys Cys Val Asn Arg 

65                  70                  75                  80  





Asn Leu Thr Glu Val Pro Thr Asp Leu Pro Ala Tyr Val Arg Asn Leu 

                85                  90                  95      





Phe Leu Thr Gly Asn Gln Leu Ala Val Leu Pro Ala Gly Ala Phe Ala 

            100                 105                 110         





Arg Arg Pro Pro Leu Ala Glu Leu Ala Ala Leu Asn Leu Ser Gly Ser 

        115                 120                 125             





Arg Leu Asp Glu Val Arg Ala Gly Ala Phe Glu His Leu Pro Ser Leu 

    130                 135                 140                 





Arg Gln Leu Asp Leu Ser His Asn Pro Leu Ala Asp Leu Ser Pro Phe 

145                 150                 155                 160 





Ala Phe Ser Gly Ser Asn Ala Ser Val Ser Ala Pro Ser Pro Leu Val 

                165                 170                 175     





Glu Leu Ile Leu Asn His Ile Val Pro Pro Glu Asp Glu Arg Gln Asn 

            180                 185                 190         





Arg Ser Phe Glu Gly Met Val Val Ala Ala Leu Leu Ala Gly Arg Ala 

        195                 200                 205             





Leu Gln Gly Leu Arg Arg Leu Glu Leu Ala Ser Asn His Phe Leu Tyr 

    210                 215                 220                 





Leu Pro Arg Asp Val Leu Ala Gln Leu Pro Ser Leu Arg His Leu Asp 

225                 230                 235                 240 





Leu Ser Asn Asn Ser Leu Val Ser Leu Thr Tyr Val Ser Phe Arg Asn 

                245                 250                 255     





Leu Thr His Leu Glu Ser Leu His Leu Glu Asp Asn Ala Leu Lys Val 

            260                 265                 270         





Leu His Asn Gly Thr Leu Ala Glu Leu Gln Gly Leu Pro His Ile Arg 

        275                 280                 285             





Val Phe Leu Asp Asn Asn Pro Trp Val Cys Asp Cys His Met Ala Asp 

    290                 295                 300                 





Met Val Thr Trp Leu Lys Glu Thr Glu Val Val Gln Gly Lys Asp Arg 

305                 310                 315                 320 





Leu Thr Cys Ala Tyr Pro Glu Lys Met Arg Asn Arg Val Leu Leu Glu 

                325                 330                 335     





Leu Asn Ser Ala Asp Leu Asp Cys Asp Pro Ile Leu Pro Pro Ser Leu 

            340                 345                 350         





Gln Thr Ser Tyr Val Phe Leu Gly Ile Val Leu Ala Leu Ile Gly Ala 

        355                 360                 365             





Ile Phe Leu Leu Val Leu Tyr Leu Asn Arg Lys Gly Ile Lys Lys Trp 

    370                 375                 380                 





Met His Asn Ile Arg Asp Ala Cys Arg Asp His Met Glu Gly Tyr His 

385                 390                 395                 400 





Tyr Arg Tyr Glu Ile Asn Ala Asp Pro Arg Leu Thr Asn Leu Ser Ser 

                405                 410                 415     





Asn Ser Asp Val 

            420 





<210>  223

<211>  114

<212>  PRT

<213>  Homo sapiens



<400>  223



Met Ala Gly Leu Ala Leu Gln Pro Gly Thr Ala Leu Leu Cys Tyr Ser 

1               5                   10                  15      





Cys Lys Ala Gln Val Ser Asn Glu Asp Cys Leu Gln Val Glu Asn Cys 

            20                  25                  30          





Thr Gln Leu Gly Glu Gln Cys Trp Thr Ala Arg Ile Arg Ala Val Gly 

        35                  40                  45              





Leu Leu Thr Val Ile Ser Lys Gly Cys Ser Leu Asn Cys Val Asp Asp 

    50                  55                  60                  





Ser Gln Asp Tyr Tyr Val Gly Lys Lys Asn Ile Thr Cys Cys Asp Thr 

65                  70                  75                  80  





Asp Leu Cys Asn Ala Ser Gly Ala His Ala Leu Gln Pro Ala Ala Ala 

                85                  90                  95      





Ile Leu Ala Leu Leu Pro Ala Leu Gly Leu Leu Leu Trp Gly Pro Gly 

            100                 105                 110         





Gln Leu 

        





<210>  224

<211>  719

<212>  PRT

<213>  Homo sapiens



<400>  224



Met Trp Asn Leu Leu His Glu Thr Asp Ser Ala Val Ala Thr Ala Arg 

1               5                   10                  15      





Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Phe 

            20                  25                  30          





Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Asn Glu 

        35                  40                  45              





Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu 

    50                  55                  60                  





Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln Ile 

65                  70                  75                  80  





Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile 

                85                  90                  95      





Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala His 

            100                 105                 110         





Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile 

        115                 120                 125             





Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe 

    130                 135                 140                 





Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro 

145                 150                 155                 160 





Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr 

                165                 170                 175     





Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met 

            180                 185                 190         





Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val 

        195                 200                 205             





Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys Gly 

    210                 215                 220                 





Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys 

225                 230                 235                 240 





Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly 

                245                 250                 255     





Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr 

            260                 265                 270         





Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val Gly 

        275                 280                 285             





Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys 

    290                 295                 300                 





Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg 

305                 310                 315                 320 





Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn 

                325                 330                 335     





Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu Val 

            340                 345                 350         





Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro 

        355                 360                 365             





Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly 

    370                 375                 380                 





Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg 

385                 390                 395                 400 





Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile 

                405                 410                 415     





Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr 

            420                 425                 430         





Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala 

        435                 440                 445             





Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val 

    450                 455                 460                 





Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu 

465                 470                 475                 480 





Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser 

                485                 490                 495     





Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile 

            500                 505                 510         





Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu 

        515                 520                 525             





Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn 

    530                 535                 540                 





Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu 

545                 550                 555                 560 





Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val 

                565                 570                 575     





Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val 

            580                 585                 590         





Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala 

        595                 600                 605             





Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr 

    610                 615                 620                 





Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr 

625                 630                 635                 640 





Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser 

                645                 650                 655     





Lys His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu 

            660                 665                 670         





Ser Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val 

        675                 680                 685             





Asp Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala 

    690                 695                 700                 





Ala Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 

705                 710                 715                 





<210>  225

<211>  735

<212>  PRT

<213>  Homo sapiens



<400>  225



Met Thr Ala Gly Ser Ser Tyr Pro Leu Phe Leu Ala Ala Tyr Ala Cys 

1               5                   10                  15      





Thr Gly Cys Leu Ala Glu Arg Leu Gly Trp Phe Ile Lys Ser Ser Asn 

            20                  25                  30          





Glu Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp 

        35                  40                  45              





Glu Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln 

    50                  55                  60                  





Ile Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln 

65                  70                  75                  80  





Ile Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala 

                85                  90                  95      





His Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr 

            100                 105                 110         





Ile Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu 

        115                 120                 125             





Phe Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro 

    130                 135                 140                 





Pro Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val 

145                 150                 155                 160 





Tyr Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp 

                165                 170                 175     





Met Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys 

            180                 185                 190         





Val Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys 

        195                 200                 205             





Gly Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val 

    210                 215                 220                 





Lys Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg 

225                 230                 235                 240 





Gly Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly 

                245                 250                 255     





Tyr Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val 

            260                 265                 270         





Gly Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln 

        275                 280                 285             





Lys Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp 

    290                 295                 300                 





Arg Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly 

305                 310                 315                 320 





Asn Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu 

                325                 330                 335     





Val Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu 

            340                 345                 350         





Pro Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe 

        355                 360                 365             





Gly Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val 

    370                 375                 380                 





Arg Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr 

385                 390                 395                 400 





Ile Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser 

                405                 410                 415     





Thr Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val 

            420                 425                 430         





Ala Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg 

        435                 440                 445             





Val Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys 

    450                 455                 460                 





Glu Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu 

465                 470                 475                 480 





Ser Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg 

                485                 490                 495     





Ile Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg 

            500                 505                 510         





Leu Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr 

        515                 520                 525             





Asn Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr 

    530                 535                 540                 





Glu Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr 

545                 550                 555                 560 





Val Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile 

                565                 570                 575     





Val Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr 

            580                 585                 590         





Ala Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys 

        595                 600                 605             





Thr Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe 

    610                 615                 620                 





Thr Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys 

625                 630                 635                 640 





Ser Asn Pro Ile Val Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu 

                645                 650                 655     





Glu Arg Ala Phe Ile Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr 

            660                 665                 670         





Arg His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu 

        675                 680                 685             





Ser Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val 

    690                 695                 700                 





Asp Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala 

705                 710                 715                 720 





Ala Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 

                725                 730                 735 





<210>  226

<211>  704

<212>  PRT

<213>  Homo sapiens



<400>  226



Met Thr Ala Gly Ser Ser Tyr Pro Leu Phe Leu Ala Ala Tyr Ala Cys 

1               5                   10                  15      





Thr Gly Cys Leu Ala Glu Arg Leu Gly Trp Phe Ile Lys Ser Ser Asn 

            20                  25                  30          





Glu Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp 

        35                  40                  45              





Glu Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln 

    50                  55                  60                  





Ile Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln 

65                  70                  75                  80  





Ile Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala 

                85                  90                  95      





His Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr 

            100                 105                 110         





Ile Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu 

        115                 120                 125             





Phe Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro 

    130                 135                 140                 





Pro Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val 

145                 150                 155                 160 





Tyr Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp 

                165                 170                 175     





Met Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys 

            180                 185                 190         





Val Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys 

        195                 200                 205             





Gly Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val 

    210                 215                 220                 





Lys Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg 

225                 230                 235                 240 





Gly Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly 

                245                 250                 255     





Tyr Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val 

            260                 265                 270         





Gly Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln 

        275                 280                 285             





Lys Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp 

    290                 295                 300                 





Arg Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly 

305                 310                 315                 320 





Asn Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu 

                325                 330                 335     





Val Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu 

            340                 345                 350         





Pro Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe 

        355                 360                 365             





Gly Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val 

    370                 375                 380                 





Arg Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr 

385                 390                 395                 400 





Ile Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser 

                405                 410                 415     





Thr Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val 

            420                 425                 430         





Ala Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg 

        435                 440                 445             





Val Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys 

    450                 455                 460                 





Glu Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu 

465                 470                 475                 480 





Ser Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg 

                485                 490                 495     





Ile Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg 

            500                 505                 510         





Leu Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr 

        515                 520                 525             





Asn Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr 

    530                 535                 540                 





Glu Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr 

545                 550                 555                 560 





Val Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile 

                565                 570                 575     





Val Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr 

            580                 585                 590         





Ala Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys 

        595                 600                 605             





Thr Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe 

    610                 615                 620                 





Thr Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys 

625                 630                 635                 640 





Ser Lys His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly 

                645                 650                 655     





Glu Ser Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys 

            660                 665                 670         





Val Asp Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val 

        675                 680                 685             





Ala Ala Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 

    690                 695                 700                 





<210>  227

<211>  442

<212>  PRT

<213>  Homo sapiens



<400>  227



Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg Gly Ser Leu Lys 

1               5                   10                  15      





Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn Phe Ser Thr Gln 

            20                  25                  30          





Lys Val Lys Met His Ile His Ser Thr Asn Glu Val Thr Arg Ile Tyr 

        35                  40                  45              





Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro Asp Arg Tyr Val 

    50                  55                  60                  





Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly Gly Ile Asp Pro 

65                  70                  75                  80  





Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg Ser Phe Gly Thr 

                85                  90                  95      





Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile Leu Phe Ala Ser 

            100                 105                 110         





Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr Glu Trp Ala Glu 

        115                 120                 125             





Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala Tyr Ile Asn Ala 

    130                 135                 140                 





Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val Asp Cys Thr Pro 

145                 150                 155                 160 





Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu Leu Lys Ser Pro 

                165                 170                 175     





Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser Trp Thr Lys Lys 

            180                 185                 190         





Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile Ser Lys Leu Gly 

        195                 200                 205             





Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu Gly Ile Ala Ser 

    210                 215                 220                 





Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn Lys Phe Ser Gly 

225                 230                 235                 240 





Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu Leu Val Glu Lys 

                245                 250                 255     





Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val Ala Gln Val Arg 

            260                 265                 270         





Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val Leu Pro Phe Asp 

        275                 280                 285             





Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala Asp Lys Ile Tyr 

    290                 295                 300                 





Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr Tyr Ser Val Ser 

305                 310                 315                 320 





Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr Glu Ile Ala Ser 

                325                 330                 335     





Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser Asn Pro Ile Val 

            340                 345                 350         





Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu Glu Arg Ala Phe Ile 

        355                 360                 365             





Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr Arg His Val Ile Tyr 

    370                 375                 380                 





Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser Phe Pro Gly Ile 

385                 390                 395                 400 





Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val Asp Pro Ser Lys Ala 

                405                 410                 415     





Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala Ala Phe Thr Val Gln 

            420                 425                 430         





Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 

        435                 440         





<210>  228

<211>  750

<212>  PRT

<213>  Homo sapiens



<400>  228



Met Trp Asn Leu Leu His Glu Thr Asp Ser Ala Val Ala Thr Ala Arg 

1               5                   10                  15      





Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Phe 

            20                  25                  30          





Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Asn Glu 

        35                  40                  45              





Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu 

    50                  55                  60                  





Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln Ile 

65                  70                  75                  80  





Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile 

                85                  90                  95      





Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala His 

            100                 105                 110         





Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile 

        115                 120                 125             





Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe 

    130                 135                 140                 





Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro 

145                 150                 155                 160 





Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr 

                165                 170                 175     





Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met 

            180                 185                 190         





Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val 

        195                 200                 205             





Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys Gly 

    210                 215                 220                 





Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys 

225                 230                 235                 240 





Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly 

                245                 250                 255     





Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr 

            260                 265                 270         





Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val Gly 

        275                 280                 285             





Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys 

    290                 295                 300                 





Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg 

305                 310                 315                 320 





Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn 

                325                 330                 335     





Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu Val 

            340                 345                 350         





Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro 

        355                 360                 365             





Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly 

    370                 375                 380                 





Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg 

385                 390                 395                 400 





Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile 

                405                 410                 415     





Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr 

            420                 425                 430         





Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala 

        435                 440                 445             





Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val 

    450                 455                 460                 





Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu 

465                 470                 475                 480 





Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser 

                485                 490                 495     





Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile 

            500                 505                 510         





Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu 

        515                 520                 525             





Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn 

    530                 535                 540                 





Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu 

545                 550                 555                 560 





Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val 

                565                 570                 575     





Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val 

            580                 585                 590         





Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala 

        595                 600                 605             





Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr 

    610                 615                 620                 





Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr 

625                 630                 635                 640 





Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser 

                645                 650                 655     





Asn Pro Ile Val Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu Glu 

            660                 665                 670         





Arg Ala Phe Ile Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr Arg 

        675                 680                 685             





His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser 

    690                 695                 700                 





Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val Asp 

705                 710                 715                 720 





Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala Ala 

                725                 730                 735     





Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 

            740                 745                 750 





<210>  229

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Amino acid sequence encoding Gag 77-85



<400>  229



Ser Leu Tyr Asn Thr Val Ala Thr Leu 

1               5                   





<210>  230

<211>  8

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Amino acid sequence encoding Pol 476-484



<400>  230



Ile Leu Glu Pro Val His Gly Val 

1               5               





<210>  231

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Amino acid sequence encoding a short peptide



<400>  231



Gly Ile Leu Gly Phe Val Phe Thr Leu 

1               5                   





<210>  232

<211>  252

<212>  PRT

<213>  Influenza virus



<400>  232



Met Ser Leu Leu Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Val Pro 

1               5                   10                  15      





Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe 

            20                  25                  30          





Ala Gly Lys Asn Thr Asp Leu Glu Ala Leu Met Glu Trp Leu Lys Thr 

        35                  40                  45              





Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe 

    50                  55                  60                  





Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val 

65                  70                  75                  80  





Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Arg Ala 

                85                  90                  95      





Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala 

            100                 105                 110         





Lys Glu Val Ala Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met 

        115                 120                 125             





Gly Leu Ile Tyr Asn Arg Met Gly Ala Val Thr Thr Glu Val Ala Phe 

    130                 135                 140                 





Ala Val Val Cys Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln His Arg 

145                 150                 155                 160 





Ser His Arg Gln Met Val Thr Thr Thr Asn Pro Leu Ile Arg His Glu 

                165                 170                 175     





Asn Arg Met Val Leu Ala Ser Thr Thr Ala Lys Ala Met Glu Gln Met 

            180                 185                 190         





Ala Gly Ser Ser Glu Gln Ala Ala Glu Ala Met Glu Val Ala Ser Gln 

        195                 200                 205             





Ala Arg Gln Met Val Gln Ala Met Arg Ala Ile Gly Thr Pro Pro Ser 

    210                 215                 220                 





Ser Ser Ala Gly Leu Lys Asp Asp Leu Leu Glu Asn Leu Gln Ala Tyr 

225                 230                 235                 240 





Gln Lys Arg Met Gly Val Gln Met Gln Arg Phe Lys 

                245                 250         





<210>  233

<211>  584

<212>  PRT

<213>  Influenza virus



<400>  233



Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 

1               5                   10                  15      





Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 

            20                  25                  30          





Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 

        35                  40                  45              





Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Gln Thr 

    50                  55                  60                  





Arg Gly Lys Leu Cys Pro Asn Cys Phe Asn Cys Thr Asp Leu Asp Val 

65                  70                  75                  80  





Ala Leu Gly Arg Pro Lys Cys Met Gly Asn Thr Pro Ser Ala Lys Val 

                85                  90                  95      





Ser Ile Leu His Glu Val Lys Pro Ala Thr Ser Gly Cys Phe Pro Ile 

            100                 105                 110         





Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 

        115                 120                 125             





Tyr Glu Asn Ile Arg Leu Ser Thr Ser Asn Val Ile Asn Thr Glu Thr 

    130                 135                 140                 





Ala Pro Gly Gly Pro Tyr Lys Val Gly Thr Ser Gly Ser Cys Pro Asn 

145                 150                 155                 160 





Val Ala Asn Gly Asn Gly Phe Phe Asn Thr Met Ala Trp Val Ile Pro 

                165                 170                 175     





Lys Asp Asn Asn Lys Thr Ala Ile Asn Pro Val Thr Val Glu Val Pro 

            180                 185                 190         





Tyr Ile Cys Ser Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His 

        195                 200                 205             





Ser Asp Asp Lys Thr Gln Met Glu Arg Leu Tyr Gly Asp Ser Asn Pro 

    210                 215                 220                 





Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser 

225                 230                 235                 240 





Gln Ile Gly Gly Phe Pro Asn Gln Thr Glu Asp Glu Gly Leu Lys Gln 

                245                 250                 255     





Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys Thr 

            260                 265                 270         





Gly Thr Ile Val Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp 

        275                 280                 285             





Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile 

    290                 295                 300                 





Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser 

305                 310                 315                 320 





Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro 

                325                 330                 335     





Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg 

            340                 345                 350         





Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala 

        355                 360                 365             





Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly 

    370                 375                 380                 





Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys 

385                 390                 395                 400 





Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Tyr Leu 

                405                 410                 415     





Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asn 

            420                 425                 430         





Glu Leu His Asp Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu 

        435                 440                 445             





Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser 

    450                 455                 460                 





Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu 

465                 470                 475                 480 





Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn 

                485                 490                 495     





Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg 

            500                 505                 510         





Ile Ala Ala Gly Thr Phe Asn Ala Gly Asp Phe Ser Leu Pro Thr Phe 

        515                 520                 525             





Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp 

    530                 535                 540                 





Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala 

545                 550                 555                 560 





Val Thr Leu Met Ile Ala Ile Phe Ile Val Tyr Met Val Ser Arg Asp 

                565                 570                 575     





Asn Val Ser Cys Ser Ile Cys Leu 

            580                 





<210>  234

<211>  566

<212>  PRT

<213>  Influenza virus



<400>  234



Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 

1               5                   10                  15      





Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 

            20                  25                  30          





His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 

        35                  40                  45              





Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 

    50                  55                  60                  





Gly Gly Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 

65                  70                  75                  80  





Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 

                85                  90                  95      





Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 

            100                 105                 110         





Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 

        115                 120                 125             





Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr 

    130                 135                 140                 





Gly Val Thr Gln Asn Gly Thr Ser Ser Ala Cys Lys Arg Arg Ser Asn 

145                 150                 155                 160 





Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Lys Phe Lys 

                165                 170                 175     





Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Lys Phe Asp Lys 

            180                 185                 190         





Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Asn Asp Gln Ile 

        195                 200                 205             





Ser Leu Tyr Ala Gln Ala Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 

    210                 215                 220                 





Ser Gln Gln Thr Val Ile Pro Ser Ile Gly Ser Arg Pro Arg Ile Arg 

225                 230                 235                 240 





Asp Val Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 

                245                 250                 255     





Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 

            260                 265                 270         





Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 

        275                 280                 285             





Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 

    290                 295                 300                 





Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 

305                 310                 315                 320 





Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 

                325                 330                 335     





Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 

            340                 345                 350         





Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 

        355                 360                 365             





Phe Arg His Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys 

    370                 375                 380                 





Ser Thr Gln Ala Ala Ile Asn Gln Ile Asn Gly Lys Leu Asn Arg Leu 

385                 390                 395                 400 





Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 

                405                 410                 415     





Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 

            420                 425                 430         





Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 

        435                 440                 445             





Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 

    450                 455                 460                 





Glu Arg Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 

465                 470                 475                 480 





Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 

                485                 490                 495     





Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 

            500                 505                 510         





Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 

        515                 520                 525             





Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 

    530                 535                 540                 





Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 

545                 550                 555                 560 





Arg Cys Asn Ile Cys Ile 

                565     





<210>  235

<211>  466

<212>  PRT

<213>  Influenza virus



<400>  235



Met Leu Pro Ser Thr Val Gln Thr Leu Thr Leu Leu Leu Thr Ser Gly 

1               5                   10                  15      





Gly Val Leu Leu Ser Leu Tyr Val Ser Ala Ser Leu Ser Tyr Leu Leu 

            20                  25                  30          





Tyr Ser Asp Val Leu Leu Lys Phe Ser Ser Thr Lys Thr Thr Ala Pro 

        35                  40                  45              





Thr Met Ser Leu Glu Cys Thr Asn Ala Ser Asn Ala Gln Thr Val Asn 

    50                  55                  60                  





His Ser Ala Thr Lys Glu Met Thr Phe Pro Pro Pro Glu Pro Glu Trp 

65                  70                  75                  80  





Thr Tyr Pro Arg Leu Ser Cys Gln Gly Ser Thr Phe Gln Lys Ala Leu 

                85                  90                  95      





Leu Ile Ser Pro His Arg Phe Gly Glu Ile Lys Gly Asn Ser Ala Pro 

            100                 105                 110         





Leu Ile Ile Arg Glu Pro Phe Val Ala Cys Gly Pro Lys Glu Cys Arg 

        115                 120                 125             





His Phe Ala Leu Thr His Tyr Ala Ala Gln Pro Gly Gly Tyr Tyr Asn 

    130                 135                 140                 





Gly Thr Arg Lys Asp Arg Asn Lys Leu Arg His Leu Val Ser Val Lys 

145                 150                 155                 160 





Leu Gly Lys Ile Pro Thr Val Glu Asn Ser Ile Phe His Met Ala Ala 

                165                 170                 175     





Trp Ser Gly Ser Ala Cys His Asp Gly Arg Glu Trp Thr Tyr Ile Gly 

            180                 185                 190         





Val Asp Gly Pro Asp Asn Asp Ala Leu Val Lys Ile Lys Tyr Gly Glu 

        195                 200                 205             





Ala Tyr Thr Asp Thr Tyr His Ser Tyr Ala His Asn Ile Leu Arg Thr 

    210                 215                 220                 





Gln Glu Ser Ala Cys Asn Cys Ile Gly Gly Asp Cys Tyr Leu Met Ile 

225                 230                 235                 240 





Thr Asp Gly Ser Ala Ser Gly Ile Ser Lys Cys Arg Phe Leu Lys Ile 

                245                 250                 255     





Arg Glu Gly Arg Ile Ile Lys Glu Ile Leu Pro Thr Gly Arg Val Glu 

            260                 265                 270         





His Thr Glu Glu Cys Thr Cys Gly Phe Ala Ser Asn Lys Thr Ile Glu 

        275                 280                 285             





Cys Ala Cys Arg Asp Asn Ser Tyr Thr Ala Lys Arg Pro Phe Val Lys 

    290                 295                 300                 





Leu Asn Val Glu Thr Asp Thr Ala Glu Ile Arg Leu Met Cys Thr Lys 

305                 310                 315                 320 





Thr Tyr Leu Asp Thr Pro Arg Pro Asp Asp Gly Ser Ile Ala Gly Pro 

                325                 330                 335     





Cys Glu Ser Asn Gly Asp Lys Trp Leu Gly Gly Ile Lys Gly Gly Phe 

            340                 345                 350         





Val His Gln Arg Met Ala Ser Lys Ile Gly Arg Trp Tyr Ser Arg Thr 

        355                 360                 365             





Met Ser Lys Thr Asn Arg Met Gly Met Glu Leu Tyr Val Lys Tyr Asp 

    370                 375                 380                 





Gly Asp Pro Trp Thr Asp Ser Asp Ala Leu Thr Leu Ser Gly Val Met 

385                 390                 395                 400 





Val Ser Ile Glu Glu Pro Gly Trp Tyr Ser Phe Gly Phe Glu Ile Lys 

                405                 410                 415     





Asp Lys Lys Cys Asp Val Pro Cys Ile Gly Ile Glu Met Val His Asp 

            420                 425                 430         





Gly Gly Lys Asp Thr Trp His Ser Ala Ala Thr Ala Ile Tyr Cys Leu 

        435                 440                 445             





Met Gly Ser Gly Gln Leu Leu Trp Asp Thr Val Thr Gly Val Asp Met 

    450                 455                 460                 





Ala Leu 

465     





<210>  236

<211>  565

<212>  PRT

<213>  Influenza virus



<400>  236



Met Ser Asp Arg Arg Gln Asn Arg Lys Thr Pro Asp Glu Gln Arg Lys 

1               5                   10                  15      





Ala Asn Ala Leu Ile Ile Asn Glu Asn Ile Glu Ala Tyr Ile Ala Ile 

            20                  25                  30          





Cys Lys Glu Val Gly Leu Asn Gly Asp Glu Met Leu Ile Leu Glu Asn 

        35                  40                  45              





Gly Ile Ala Ile Glu Lys Ala Ile Arg Ile Cys Cys Asp Gly Lys Tyr 

    50                  55                  60                  





Gln Glu Lys Arg Glu Lys Lys Ala Arg Glu Ala Gln Arg Ala Asp Ser 

65                  70                  75                  80  





Asn Phe Asn Ala Asp Ser Ile Gly Ile Arg Leu Val Lys Arg Ala Gly 

                85                  90                  95      





Ser Gly Thr Asn Ile Thr Tyr His Ala Val Val Glu Leu Thr Ser Arg 

            100                 105                 110         





Ser Arg Ile Val Gln Ile Leu Lys Ser His Trp Gly Asn Glu Leu Asn 

        115                 120                 125             





Arg Ala Lys Ile Ala Gly Lys Arg Leu Gly Phe Ser Ala Leu Phe Ala 

    130                 135                 140                 





Ser Asn Leu Glu Ala Ile Ile Tyr Gln Arg Gly Arg Asn Ala Ala Arg 

145                 150                 155                 160 





Arg Asn Gly Ser Ala Glu Leu Phe Thr Leu Thr Gln Gly Ala Gly Ile 

                165                 170                 175     





Glu Thr Arg Tyr Lys Trp Ile Met Glu Lys His Ile Gly Ile Gly Val 

            180                 185                 190         





Leu Ile Ala Asp Ala Lys Gly Leu Ile Asn Gly Lys Arg Glu Gly Lys 

        195                 200                 205             





Arg Gly Val Asp Ala Asn Val Lys Leu Arg Ala Gly Thr Thr Gly Ser 

    210                 215                 220                 





Pro Leu Glu Arg Ala Met Gln Gly Ile Glu Lys Lys Ala Phe Pro Gly 

225                 230                 235                 240 





Pro Leu Arg Ala Leu Ala Arg Arg Val Val Lys Ala Asn Tyr Asn Asp 

                245                 250                 255     





Ala Arg Glu Ala Leu Asn Val Ile Ala Glu Ala Ser Leu Leu Leu Lys 

            260                 265                 270         





Pro Gln Ile Thr Asn Lys Met Thr Met Pro Trp Cys Met Trp Leu Ala 

        275                 280                 285             





Ala Arg Leu Thr Leu Lys Asp Glu Phe Ala Asn Phe Cys Ala Tyr Ala 

    290                 295                 300                 





Gly Arg Arg Ala Phe Glu Val Phe Asn Ile Ala Met Glu Lys Ile Gly 

305                 310                 315                 320 





Ile Cys Ser Phe Gln Gly Thr Ile Met Asn Asp Asp Glu Ile Glu Ser 

                325                 330                 335     





Ile Glu Asp Lys Ala Gln Val Leu Met Met Ala Cys Phe Gly Leu Ala 

            340                 345                 350         





Tyr Glu Asp Phe Ser Leu Val Ser Ala Met Val Ser His Pro Leu Lys 

        355                 360                 365             





Leu Arg Asn Arg Met Lys Ile Gly Asn Phe Arg Val Gly Glu Lys Val 

    370                 375                 380                 





Ser Thr Val Leu Ser Pro Leu Leu Arg Phe Thr Arg Trp Ala Glu Phe 

385                 390                 395                 400 





Ala Gln Arg Phe Ala Leu Gln Ala Asn Thr Ser Arg Glu Gly Ala Gln 

                405                 410                 415     





Ile Ser Asn Ser Ala Val Phe Ala Val Glu Arg Lys Ile Thr Thr Asp 

            420                 425                 430         





Val Gln Arg Val Glu Glu Leu Leu Asn Lys Val Gln Ala His Glu Asp 

        435                 440                 445             





Glu Pro Leu Gln Thr Leu Tyr Lys Lys Val Arg Glu Gln Ile Ser Ile 

    450                 455                 460                 





Ile Gly Arg Asn Lys Ser Glu Ile Lys Glu Phe Leu Gly Ser Ser Met 

465                 470                 475                 480 





Tyr Asp Leu Asn Asp Gln Glu Lys Gln Asn Pro Ile Asn Phe Arg Ser 

                485                 490                 495     





Gly Ala His Pro Phe Phe Phe Glu Phe Asp Pro Asp Tyr Asn Pro Ile 

            500                 505                 510         





Arg Val Lys Arg Pro Lys Lys Pro Ile Ala Lys Arg Asn Ser Asn Ile 

        515                 520                 525             





Ser Arg Leu Glu Glu Glu Gly Met Asp Glu Asn Ser Glu Ile Gly Gln 

    530                 535                 540                 





Ala Lys Lys Met Lys Pro Leu Asp Gln Leu Thr Ser Thr Ser Ser Asn 

545                 550                 555                 560 





Ile Pro Gly Lys Asn 

                565 





<210>  237

<211>  498

<212>  PRT

<213>  Influenza virus



<400>  237



Met Ala Ser Gln Gly Thr Lys Arg Ser Tyr Glu Gln Met Glu Thr Asp 

1               5                   10                  15      





Gly Glu Arg Gln Asn Ala Thr Glu Ile Arg Ala Ser Val Gly Lys Met 

            20                  25                  30          





Ile Asp Gly Ile Gly Arg Phe Tyr Ile Gln Met Cys Thr Glu Leu Lys 

        35                  40                  45              





Leu Ser Asp Tyr Glu Gly Arg Leu Ile Gln Asn Ser Leu Thr Ile Glu 

    50                  55                  60                  





Arg Met Val Leu Ser Ala Phe Asp Glu Arg Arg Asn Lys Tyr Leu Glu 

65                  70                  75                  80  





Glu His Pro Ser Ala Gly Lys Asp Pro Lys Lys Thr Gly Gly Pro Ile 

                85                  90                  95      





Tyr Lys Arg Val Asp Gly Lys Trp Met Arg Glu Leu Val Leu Tyr Asp 

            100                 105                 110         





Lys Glu Glu Ile Arg Arg Ile Trp Arg Gln Ala Asn Asn Gly Asp Asp 

        115                 120                 125             





Ala Thr Ala Gly Leu Thr His Met Met Ile Trp His Ser Asn Leu Asn 

    130                 135                 140                 





Asp Thr Thr Tyr Gln Arg Thr Arg Ala Leu Val Arg Thr Gly Met Asp 

145                 150                 155                 160 





Pro Arg Met Cys Ser Leu Met Gln Gly Ser Thr Leu Pro Arg Arg Ser 

                165                 170                 175     





Gly Ala Ala Gly Ala Ala Val Lys Gly Val Gly Thr Met Val Met Glu 

            180                 185                 190         





Leu Ile Arg Met Ile Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg 

        195                 200                 205             





Gly Glu Asn Gly Arg Lys Thr Arg Ser Ala Tyr Glu Arg Met Cys Asn 

    210                 215                 220                 





Ile Leu Lys Gly Lys Phe Gln Thr Ala Ala Gln Arg Ala Met Met Asp 

225                 230                 235                 240 





Gln Val Arg Glu Ser Arg Asn Pro Gly Asn Ala Glu Ile Glu Asp Leu 

                245                 250                 255     





Ile Phe Leu Ala Arg Ser Ala Leu Ile Leu Arg Gly Ser Val Ala His 

            260                 265                 270         





Lys Ser Cys Leu Pro Ala Cys Val Tyr Gly Pro Ala Ile Ala Ser Gly 

        275                 280                 285             





Tyr Asn Phe Glu Lys Glu Gly Tyr Ser Leu Val Gly Ile Asp Pro Phe 

    290                 295                 300                 





Lys Leu Leu Gln Asn Ser Gln Val Tyr Ser Leu Ile Arg Pro Asn Glu 

305                 310                 315                 320 





Asn Pro Ala His Lys Ser Gln Leu Val Trp Met Ala Cys Asn Ser Ala 

                325                 330                 335     





Ala Phe Glu Asp Leu Arg Val Leu Ser Phe Ile Arg Gly Thr Lys Val 

            340                 345                 350         





Ser Pro Arg Gly Lys Leu Ser Thr Arg Gly Val Gln Ile Ala Ser Asn 

        355                 360                 365             





Glu Asn Met Asp Thr Met Glu Ser Ser Thr Leu Glu Leu Arg Ser Arg 

    370                 375                 380                 





Tyr Trp Ala Ile Arg Thr Arg Ser Gly Gly Asn Thr Asn Gln Gln Arg 

385                 390                 395                 400 





Ala Ser Ala Gly Gln Ile Ser Val Gln Pro Ala Phe Ser Val Gln Arg 

                405                 410                 415     





Asn Leu Pro Phe Asp Lys Pro Thr Ile Met Ala Ala Phe Thr Gly Asn 

            420                 425                 430         





Thr Glu Gly Arg Thr Ser Asp Met Arg Ala Glu Ile Ile Arg Met Met 

        435                 440                 445             





Glu Gly Ala Lys Pro Glu Glu Met Ser Phe Gln Gly Arg Gly Val Phe 

    450                 455                 460                 





Glu Leu Ser Asp Glu Lys Ala Thr Asn Pro Ile Val Pro Ser Phe Asp 

465                 470                 475                 480 





Met Ser Asn Glu Gly Ser Tyr Phe Phe Gly Asp Asn Ala Glu Glu Tyr 

                485                 490                 495     





Asp Asn 

        





<210>  238

<211>  498

<212>  PRT

<213>  Influenza virus



<400>  238



Met Ala Ser Gln Gly Thr Lys Arg Ser Tyr Glu Gln Met Glu Thr Gly 

1               5                   10                  15      





Gly Glu Arg Gln Asn Ala Thr Glu Ile Arg Ala Ser Val Gly Arg Met 

            20                  25                  30          





Val Gly Gly Ile Gly Arg Phe Tyr Val Gln Met Cys Thr Glu Leu Lys 

        35                  40                  45              





Leu Ser Asp Gln Glu Gly Arg Leu Ile Gln Asn Ser Ile Thr Ile Glu 

    50                  55                  60                  





Arg Met Val Leu Ser Ala Phe Asp Glu Arg Arg Asn Arg Tyr Leu Glu 

65                  70                  75                  80  





Glu His Pro Ser Ala Gly Lys Asp Pro Lys Lys Thr Gly Gly Pro Ile 

                85                  90                  95      





Tyr Arg Arg Arg Asp Gly Lys Trp Val Arg Glu Leu Ile Leu Tyr Asp 

            100                 105                 110         





Lys Glu Glu Ile Arg Arg Ile Trp Arg Gln Ala Asn Asn Gly Glu Asp 

        115                 120                 125             





Ala Thr Ala Gly Leu Thr His Met Met Ile Trp His Ser Asn Leu Asn 

    130                 135                 140                 





Asp Ala Thr Tyr Gln Arg Thr Arg Ala Leu Val Arg Thr Gly Met Asp 

145                 150                 155                 160 





Pro Arg Met Cys Ser Leu Met Gln Gly Ser Thr Leu Pro Arg Arg Ser 

                165                 170                 175     





Gly Ala Ala Gly Ala Ala Ile Lys Gly Val Gly Thr Met Val Met Glu 

            180                 185                 190         





Leu Ile Arg Met Ile Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg 

        195                 200                 205             





Gly Asp Asn Gly Arg Arg Thr Arg Ile Ala Tyr Glu Arg Met Cys Asn 

    210                 215                 220                 





Ile Leu Lys Gly Lys Phe Gln Thr Ala Ala Gln Arg Ala Met Met Asp 

225                 230                 235                 240 





Gln Val Arg Glu Ser Arg Asn Pro Gly Asn Ala Glu Ile Glu Asp Leu 

                245                 250                 255     





Ile Phe Leu Ala Arg Ser Ala Leu Ile Leu Arg Gly Ser Val Ala His 

            260                 265                 270         





Lys Ser Cys Leu Pro Ala Cys Val Tyr Gly Leu Ala Val Ala Ser Gly 

        275                 280                 285             





Tyr Asp Phe Glu Arg Glu Gly Tyr Ser Leu Val Gly Ile Asp Pro Phe 

    290                 295                 300                 





Arg Leu Leu Gln Asn Ser Gln Val Phe Ser Leu Ile Arg Pro Asn Glu 

305                 310                 315                 320 





Asn Pro Ala His Lys Ser Gln Leu Val Trp Met Ala Cys His Ser Ala 

                325                 330                 335     





Ala Phe Glu Asp Leu Arg Val Ser Ser Phe Ile Arg Gly Thr Arg Val 

            340                 345                 350         





Ile Pro Arg Gly Gln Leu Ser Thr Arg Gly Val Gln Ile Ala Ser Asn 

        355                 360                 365             





Glu Asn Val Glu Ala Met Asp Ser Ser Thr Leu Glu Leu Arg Ser Arg 

    370                 375                 380                 





Tyr Trp Ala Ile Arg Thr Arg Ser Gly Gly Asn Thr Asn Gln Gln Arg 

385                 390                 395                 400 





Ala Ser Ala Gly Gln Ile Ser Val Gln Pro Thr Phe Ser Val Gln Arg 

                405                 410                 415     





Asn Leu Pro Phe Glu Arg Pro Thr Ile Met Ala Ala Phe Lys Gly Asn 

            420                 425                 430         





Thr Glu Gly Arg Thr Ser Asp Met Arg Thr Glu Ile Ile Arg Met Met 

        435                 440                 445             





Glu Ser Ala Arg Pro Glu Asp Val Ser Phe Gln Gly Arg Gly Val Phe 

    450                 455                 460                 





Glu Leu Ser Asp Glu Lys Ala Thr Asn Pro Ile Val Pro Ser Phe Asp 

465                 470                 475                 480 





Met Ser Asn Glu Gly Ser Tyr Phe Phe Gly Asp Asn Ala Glu Glu Tyr 

                485                 490                 495     





Asp Asn 

        





<210>  239

<211>  560

<212>  PRT

<213>  Influenza virus



<400>  239



Met Ser Asn Met Asp Ile Asp Ser Ile Asn Thr Gly Thr Ile Asp Lys 

1               5                   10                  15      





Thr Pro Glu Glu Leu Thr Pro Gly Thr Ser Gly Ala Thr Arg Pro Ile 

            20                  25                  30          





Ile Lys Pro Ala Thr Leu Ala Pro Pro Ser Asn Lys Arg Thr Arg Asn 

        35                  40                  45              





Pro Ser Pro Glu Arg Thr Thr Thr Ser Ser Glu Thr Asp Ile Gly Arg 

    50                  55                  60                  





Lys Ile Gln Lys Lys Gln Thr Pro Thr Glu Ile Lys Lys Ser Val Tyr 

65                  70                  75                  80  





Lys Met Val Val Lys Leu Gly Glu Phe Tyr Asn Gln Met Met Val Lys 

                85                  90                  95      





Ala Gly Leu Asn Asp Asp Met Glu Arg Asn Leu Ile Gln Asn Ala Gln 

            100                 105                 110         





Ala Val Glu Arg Ile Leu Leu Ala Ala Thr Asp Asp Lys Lys Thr Glu 

        115                 120                 125             





Tyr Gln Lys Lys Arg Asn Ala Arg Asp Val Lys Glu Gly Lys Glu Glu 

    130                 135                 140                 





Ile Asp His Asn Lys Thr Gly Gly Thr Phe Tyr Lys Met Val Arg Asp 

145                 150                 155                 160 





Asp Lys Thr Ile Tyr Phe Ser Pro Ile Lys Ile Thr Phe Leu Lys Glu 

                165                 170                 175     





Glu Val Lys Thr Met Tyr Lys Thr Thr Met Gly Ser Asp Gly Phe Ser 

            180                 185                 190         





Gly Leu Asn His Ile Met Ile Gly His Ser Gln Met Asn Asp Val Cys 

        195                 200                 205             





Phe Gln Arg Ser Lys Gly Leu Lys Arg Val Gly Leu Asp Pro Ser Leu 

    210                 215                 220                 





Ile Ser Thr Phe Ala Gly Ser Thr Leu Pro Arg Arg Ser Gly Thr Thr 

225                 230                 235                 240 





Gly Val Ala Ile Lys Gly Gly Gly Thr Leu Val Asp Glu Ala Ile Arg 

                245                 250                 255     





Phe Ile Gly Arg Ala Met Ala Asp Arg Gly Leu Leu Arg Asp Ile Lys 

            260                 265                 270         





Ala Lys Thr Ala Tyr Glu Lys Ile Leu Leu Asn Leu Lys Asn Lys Cys 

        275                 280                 285             





Ser Ala Pro Gln Gln Lys Ala Leu Val Asp Gln Val Ile Gly Ser Arg 

    290                 295                 300                 





Asn Pro Gly Ile Ala Asp Ile Glu Asp Leu Thr Leu Leu Ala Arg Ser 

305                 310                 315                 320 





Met Val Val Val Arg Pro Ser Val Ala Ser Lys Val Val Leu Pro Ile 

                325                 330                 335     





Ser Ile Tyr Ala Lys Ile Pro Gln Leu Gly Phe Asn Thr Glu Glu Tyr 

            340                 345                 350         





Ser Met Val Gly Tyr Glu Ala Met Ala Leu Tyr Asn Met Ala Thr Pro 

        355                 360                 365             





Val Ser Ile Leu Arg Met Gly Asp Asp Ala Lys Asp Lys Ser Gln Leu 

    370                 375                 380                 





Phe Phe Met Ser Cys Phe Gly Ala Ala Tyr Glu Asp Leu Arg Val Leu 

385                 390                 395                 400 





Ser Ala Leu Thr Gly Thr Glu Phe Lys Pro Arg Ser Ala Leu Lys Cys 

                405                 410                 415     





Lys Gly Phe His Val Pro Ala Lys Glu Gln Val Glu Gly Met Gly Ala 

            420                 425                 430         





Ala Leu Met Ser Ile Lys Leu Gln Phe Trp Ala Pro Met Thr Arg Ser 

        435                 440                 445             





Gly Gly Asn Glu Val Ser Gly Glu Gly Gly Ser Gly Gln Ile Ser Cys 

    450                 455                 460                 





Ser Pro Val Phe Ala Val Glu Arg Pro Ile Ala Leu Ser Lys Gln Ala 

465                 470                 475                 480 





Val Arg Arg Met Leu Ser Met Asn Val Glu Gly Arg Asp Ala Asp Val 

                485                 490                 495     





Lys Gly Asn Leu Leu Lys Met Met Asn Asp Ser Met Ala Lys Lys Thr 

            500                 505                 510         





Ser Gly Asn Ala Phe Ile Gly Lys Lys Met Phe Gln Ile Ser Asp Lys 

        515                 520                 525             





Asn Lys Val Asn Pro Ile Glu Ile Pro Ile Lys Gln Thr Ile Pro Asn 

    530                 535                 540                 





Phe Phe Phe Gly Arg Asp Thr Ala Glu Asp Tyr Asp Asp Leu Asp Tyr 

545                 550                 555                 560 





<210>  240

<211>  248

<212>  PRT

<213>  Influenza virus



<400>  240



Met Ser Leu Phe Gly Asp Thr Ile Ala Tyr Leu Leu Ser Leu Ile Glu 

1               5                   10                  15      





Asp Gly Glu Gly Lys Ala Glu Leu Ala Glu Lys Leu His Cys Trp Phe 

            20                  25                  30          





Gly Gly Lys Glu Phe Asp Leu Asp Ser Ala Leu Glu Trp Ile Lys Asn 

        35                  40                  45              





Lys Arg Cys Leu Thr Asp Ile Gln Lys Ala Leu Ile Gly Ala Ser Ile 

    50                  55                  60                  





Cys Phe Leu Lys Pro Lys Asp Gln Glu Arg Lys Arg Arg Phe Ile Thr 

65                  70                  75                  80  





Glu Pro Leu Ser Gly Met Gly Thr Thr Ala Thr Lys Lys Lys Gly Leu 

                85                  90                  95      





Ile Leu Ala Glu Arg Lys Met Arg Arg Cys Val Ser Phe His Glu Ala 

            100                 105                 110         





Phe Glu Ile Ala Glu Gly His Glu Ser Ser Ala Leu Leu Tyr Cys Leu 

        115                 120                 125             





Met Val Met Tyr Leu Asn Pro Glu Asn Tyr Ser Met Gln Val Lys Leu 

    130                 135                 140                 





Gly Thr Leu Cys Ala Leu Cys Glu Lys Gln Ala Ser His Ser His Arg 

145                 150                 155                 160 





Ala His Ser Arg Ala Ala Arg Ser Ser Val Pro Gly Val Arg Arg Glu 

                165                 170                 175     





Met Gln Met Val Ser Ala Met Asn Thr Ala Lys Thr Met Asn Gly Met 

            180                 185                 190         





Gly Lys Gly Glu Asp Val Gln Lys Leu Ala Glu Glu Leu Gln Asn Asn 

        195                 200                 205             





Ile Gly Val Leu Arg Ser Leu Gly Ala Ser Gln Lys Asn Gly Glu Gly 

    210                 215                 220                 





Ile Ala Lys Asp Val Met Glu Val Leu Lys Gln Ser Ser Met Gly Asn 

225                 230                 235                 240 





Ser Ala Leu Val Arg Lys Tyr Leu 

                245             





<210>  241

<211>  97

<212>  PRT

<213>  Influenza virus



<400>  241



Met Ser Leu Leu Thr Glu Val Glu Thr Pro Ile Arg Asn Glu Trp Gly 

1               5                   10                  15      





Cys Arg Cys Asn Gly Ser Ser Asp Pro Leu Ala Ile Ala Ala Asn Ile 

            20                  25                  30          





Ile Gly Ile Leu His Leu Ile Leu Trp Ile Leu Asp Arg Leu Phe Phe 

        35                  40                  45              





Lys Cys Ile Tyr Arg Arg Phe Lys Tyr Gly Leu Lys Gly Gly Pro Ser 

    50                  55                  60                  





Thr Glu Gly Val Pro Lys Ser Met Arg Glu Glu Tyr Arg Lys Glu Gln 

65                  70                  75                  80  





Gln Ser Ala Val Asp Ala Asp Asp Gly His Phe Val Ser Ile Glu Leu 

                85                  90                  95      





Glu 

    





<210>  242

<211>  281

<212>  PRT

<213>  Influenza virus



<400>  242



Met Ala Asp Asn Met Thr Thr Thr Gln Ile Glu Val Gly Pro Gly Ala 

1               5                   10                  15      





Thr Asn Ala Thr Ile Asn Phe Glu Ala Gly Ile Leu Glu Cys Tyr Glu 

            20                  25                  30          





Arg Phe Ser Trp Gln Arg Ala Leu Asp Tyr Pro Gly Gln Asp Arg Leu 

        35                  40                  45              





His Arg Leu Lys Arg Lys Leu Glu Ser Arg Ile Lys Thr His Asn Lys 

    50                  55                  60                  





Ser Glu Pro Glu Asn Lys Arg Met Ser Leu Glu Glu Arg Lys Ala Ile 

65                  70                  75                  80  





Gly Val Lys Met Met Lys Val Leu Leu Phe Met Asp Pro Ser Ala Gly 

                85                  90                  95      





Ile Glu Gly Phe Glu Pro Tyr Cys Val Lys Asn Pro Ser Thr Ser Lys 

            100                 105                 110         





Cys Pro Asn Tyr Asp Trp Thr Asp Tyr Pro Pro Thr Pro Gly Lys Tyr 

        115                 120                 125             





Leu Asp Asp Ile Glu Glu Glu Pro Glu Asn Val Asp His Pro Ile Glu 

    130                 135                 140                 





Val Val Leu Arg Asp Met Asn Asn Lys Asp Ala Arg Gln Lys Ile Lys 

145                 150                 155                 160 





Asp Glu Val Asn Thr Gln Lys Glu Gly Lys Phe Arg Leu Thr Ile Lys 

                165                 170                 175     





Arg Asp Ile Arg Asn Val Leu Ser Leu Arg Val Leu Val Asn Gly Thr 

            180                 185                 190         





Phe Leu Lys His Pro Asn Gly Asp Lys Ser Leu Ser Thr Leu His Arg 

        195                 200                 205             





Leu Asn Ala Tyr Asp Gln Asn Gly Gly Leu Val Ala Lys Leu Val Ala 

    210                 215                 220                 





Thr Asp Asp Arg Thr Val Glu Asp Glu Lys Asp Gly His Arg Ile Leu 

225                 230                 235                 240 





Asn Ser Leu Phe Glu Arg Phe Asp Glu Gly His Ser Lys Pro Ile Arg 

                245                 250                 255     





Ala Ala Glu Thr Ala Val Gly Val Leu Ser Gln Phe Gly Gln Glu His 

            260                 265                 270         





Arg Leu Ser Pro Glu Glu Gly Asp Asn 

        275                 280     





<210>  243

<211>  122

<212>  PRT

<213>  Influenza virus



<400>  243



Met Ala Asp Asn Met Thr Thr Thr Gln Ile Glu Trp Arg Met Lys Lys 

1               5                   10                  15      





Met Ala Ile Gly Ser Ser Thr His Ser Ser Ser Val Leu Met Lys Asp 

            20                  25                  30          





Ile Gln Ser Gln Phe Glu Gln Leu Lys Leu Arg Trp Glu Ser Tyr Pro 

        35                  40                  45              





Asn Leu Val Lys Ser Thr Asp Tyr His Gln Lys Arg Glu Thr Ile Arg 

    50                  55                  60                  





Leu Ala Thr Glu Glu Leu Tyr Leu Leu Ser Lys Arg Ile Asp Asp Ser 

65                  70                  75                  80  





Ile Leu Phe His Lys Thr Val Ile Ala Asn Ser Ser Ile Ile Ala Asp 

                85                  90                  95      





Met Ile Val Ser Leu Ser Leu Leu Glu Thr Leu Tyr Glu Met Lys Asp 

            100                 105                 110         





Val Val Glu Val Tyr Ser Arg Gln Cys Leu 

        115                 120         





<210>  244

<211>  716

<212>  PRT

<213>  Influenza virus



<400>  244



Met Glu Asp Phe Val Arg Gln Cys Phe Asn Pro Met Ile Val Glu Leu 

1               5                   10                  15      





Ala Glu Lys Ala Met Lys Glu Tyr Gly Glu Asp Leu Lys Ile Glu Thr 

            20                  25                  30          





Asn Lys Phe Ala Ala Ile Cys Thr His Leu Glu Val Cys Phe Met Tyr 

        35                  40                  45              





Ser Asp Phe His Phe Ile Asn Glu Gln Gly Glu Ser Ile Ile Val Glu 

    50                  55                  60                  





Pro Glu Asp Pro Asn Ala Leu Leu Lys His Arg Phe Glu Ile Ile Glu 

65                  70                  75                  80  





Gly Arg Asp Arg Thr Met Ala Trp Thr Val Val Asn Ser Ile Cys Asn 

                85                  90                  95      





Thr Thr Gly Ala Glu Lys Pro Lys Phe Leu Pro Asp Leu Tyr Asp Tyr 

            100                 105                 110         





Lys Glu Asn Arg Phe Ile Glu Ile Gly Val Thr Arg Arg Glu Val His 

        115                 120                 125             





Ile Tyr Tyr Leu Glu Lys Ala Asn Lys Ile Lys Ser Glu Lys Thr His 

    130                 135                 140                 





Ile His Ile Phe Ser Phe Thr Gly Glu Glu Met Ala Thr Lys Ala Asp 

145                 150                 155                 160 





Tyr Thr Leu Asp Glu Glu Ser Arg Ala Arg Ile Lys Thr Arg Leu Phe 

                165                 170                 175     





Thr Ile Arg Gln Glu Met Ala Ser Arg Gly Leu Trp Asp Ser Phe Arg 

            180                 185                 190         





Gln Ser Glu Arg Gly Glu Glu Thr Ile Glu Glu Arg Phe Glu Ile Thr 

        195                 200                 205             





Gly Thr Met Arg Arg Leu Ala Asp Gln Ser Leu Pro Pro Asn Phe Ser 

    210                 215                 220                 





Cys Leu Glu Asn Phe Arg Ala Tyr Val Asp Gly Phe Glu Pro Asn Gly 

225                 230                 235                 240 





Tyr Ile Glu Gly Lys Leu Ser Gln Met Ser Lys Glu Val Asn Ala Arg 

                245                 250                 255     





Ile Glu Pro Phe Leu Arg Thr Thr Pro Arg Pro Ile Arg Leu Pro Asp 

            260                 265                 270         





Gly Pro Pro Cys Phe Gln Arg Ser Lys Phe Leu Leu Met Asp Ser Leu 

        275                 280                 285             





Lys Leu Ser Ile Glu Asp Pro Ser His Glu Gly Glu Gly Ile Pro Leu 

    290                 295                 300                 





Tyr Asp Ala Ile Lys Cys Met Arg Thr Phe Phe Gly Trp Lys Glu Pro 

305                 310                 315                 320 





Ser Val Val Lys Pro His Gly Lys Gly Ile Asn Pro Asn Tyr Leu Leu 

                325                 330                 335     





Ser Trp Lys Gln Val Leu Ala Glu Leu Gln Asp Ile Glu Ser Glu Glu 

            340                 345                 350         





Lys Ile Pro Arg Thr Lys Asn Met Lys Lys Thr Ser Gln Leu Lys Trp 

        355                 360                 365             





Ala Leu Gly Glu Asn Met Ala Pro Glu Lys Val Asp Phe Asp Asp Cys 

    370                 375                 380                 





Lys Asp Ile Ser Asp Leu Lys Gln Tyr Asp Ser Asp Glu Pro Glu Leu 

385                 390                 395                 400 





Arg Ser Leu Ser Ser Trp Ile Gln Asn Glu Phe Asn Lys Ala Cys Glu 

                405                 410                 415     





Leu Thr Asp Ser Ile Trp Ile Glu Leu Asp Glu Ile Gly Glu Asp Val 

            420                 425                 430         





Ala Pro Ile Glu His Ile Ala Ser Met Arg Arg Asn Tyr Phe Thr Ala 

        435                 440                 445             





Glu Val Ser His Cys Arg Ala Thr Glu Tyr Ile Met Lys Gly Val Tyr 

    450                 455                 460                 





Ile Asn Thr Ala Leu Leu Asn Ala Ser Cys Ala Ala Met Asp Asp Phe 

465                 470                 475                 480 





Gln Leu Ile Pro Met Ile Ser Lys Cys Arg Thr Lys Glu Gly Arg Arg 

                485                 490                 495     





Lys Thr Asn Leu Tyr Gly Phe Ile Ile Lys Gly Arg Ser His Leu Arg 

            500                 505                 510         





Asn Asp Thr Asp Val Val Asn Phe Val Ser Met Glu Phe Ser Leu Thr 

        515                 520                 525             





Asp Pro Arg Leu Glu Pro His Lys Trp Glu Lys Tyr Cys Val Leu Glu 

    530                 535                 540                 





Ile Gly Asp Met Leu Leu Arg Ser Ala Ile Gly Gln Val Ser Arg Pro 

545                 550                 555                 560 





Met Phe Leu Tyr Val Arg Thr Asn Gly Thr Ser Lys Ile Lys Met Lys 

                565                 570                 575     





Trp Gly Met Glu Met Arg Arg Cys Leu Leu Gln Ser Leu Gln Gln Ile 

            580                 585                 590         





Glu Ser Met Ile Glu Ala Glu Ser Ser Val Lys Glu Lys Asp Met Thr 

        595                 600                 605             





Lys Glu Phe Phe Glu Asn Arg Ser Glu Thr Trp Pro Ile Gly Glu Ser 

    610                 615                 620                 





Pro Lys Gly Val Glu Glu Gly Ser Ile Gly Lys Val Cys Arg Thr Leu 

625                 630                 635                 640 





Leu Ala Lys Ser Val Phe Asn Ser Leu Tyr Ala Ser Pro Gln Leu Glu 

                645                 650                 655     





Gly Phe Ser Ala Glu Ser Arg Lys Leu Leu Leu Ile Val Gln Ala Leu 

            660                 665                 670         





Arg Asp Asn Leu Glu Pro Gly Thr Phe Asp Leu Gly Gly Leu Tyr Glu 

        675                 680                 685             





Ala Ile Glu Glu Cys Leu Ile Asn Asp Pro Trp Val Leu Leu Asn Ala 

    690                 695                 700                 





Ser Trp Phe Asn Ser Phe Leu Thr His Ala Leu Arg 

705                 710                 715     





<210>  245

<211>  752

<212>  PRT

<213>  Influenza virus



<400>  245



Met Asn Ile Asn Pro Tyr Phe Leu Phe Ile Asp Val Pro Ile Gln Ala 

1               5                   10                  15      





Ala Ile Ser Thr Thr Phe Pro Tyr Thr Gly Val Pro Pro Tyr Ser His 

            20                  25                  30          





Gly Thr Gly Thr Gly Tyr Thr Ile Asp Thr Val Ile Arg Thr His Glu 

        35                  40                  45              





Tyr Ser Asn Lys Gly Lys Gln Tyr Ile Ser Asp Val Thr Gly Cys Val 

    50                  55                  60                  





Met Val Asp Pro Thr Asn Gly Pro Leu Pro Glu Asp Asn Glu Pro Ser 

65                  70                  75                  80  





Ala Tyr Ala Gln Leu Asp Cys Val Leu Glu Ala Leu Asp Arg Met Asp 

                85                  90                  95      





Glu Glu His Pro Gly Leu Phe Gln Ala Gly Ser Gln Asn Ala Met Glu 

            100                 105                 110         





Ala Leu Met Val Thr Thr Val Asp Lys Leu Thr Gln Gly Arg Gln Thr 

        115                 120                 125             





Phe Asp Trp Thr Val Cys Arg Asn Gln Pro Ala Ala Thr Ala Leu Asn 

    130                 135                 140                 





Thr Thr Ile Thr Ser Phe Arg Leu Asn Asp Leu Asn Gly Ala Asp Lys 

145                 150                 155                 160 





Gly Gly Leu Val Pro Phe Cys Gln Asp Ile Ile Asp Ser Leu Asp Lys 

                165                 170                 175     





Pro Glu Met Ile Phe Phe Thr Val Lys Asn Ile Lys Lys Lys Leu Pro 

            180                 185                 190         





Ala Lys Asn Arg Lys Gly Phe Leu Ile Lys Arg Ile Pro Met Lys Val 

        195                 200                 205             





Lys Asp Arg Ile Thr Arg Val Glu Tyr Ile Lys Arg Ala Leu Ser Leu 

    210                 215                 220                 





Asn Thr Met Thr Lys Asp Ala Glu Arg Gly Lys Leu Lys Arg Arg Ala 

225                 230                 235                 240 





Ile Ala Thr Ala Gly Ile Gln Ile Arg Gly Phe Val Leu Val Val Glu 

                245                 250                 255     





Asn Leu Ala Lys Asn Ile Cys Glu Asn Leu Glu Gln Ser Gly Leu Pro 

            260                 265                 270         





Val Gly Gly Asn Glu Lys Lys Ala Lys Leu Ser Asn Ala Val Ala Lys 

        275                 280                 285             





Met Leu Ser Asn Cys Pro Pro Gly Gly Ile Ser Met Thr Val Thr Gly 

    290                 295                 300                 





Asp Asn Thr Lys Trp Asn Glu Cys Leu Asn Pro Arg Ile Phe Leu Ala 

305                 310                 315                 320 





Met Thr Glu Arg Ile Thr Arg Asp Ser Pro Ile Trp Phe Arg Asp Phe 

                325                 330                 335     





Cys Ser Ile Ala Pro Val Leu Phe Ser Asn Lys Ile Ala Arg Leu Gly 

            340                 345                 350         





Lys Gly Phe Met Ile Thr Ser Lys Thr Lys Arg Leu Lys Ala Gln Ile 

        355                 360                 365             





Pro Cys Pro Asp Leu Phe Asn Ile Pro Leu Glu Arg Tyr Asn Glu Glu 

    370                 375                 380                 





Thr Arg Ala Lys Leu Lys Lys Leu Lys Pro Phe Phe Asn Glu Glu Gly 

385                 390                 395                 400 





Thr Ala Ser Leu Ser Pro Gly Met Met Met Gly Met Phe Asn Met Leu 

                405                 410                 415     





Ser Thr Val Leu Gly Val Ala Ala Leu Gly Ile Lys Asn Ile Gly Asn 

            420                 425                 430         





Lys Glu Tyr Leu Trp Asp Gly Leu Gln Ser Ser Asp Asp Phe Ala Leu 

        435                 440                 445             





Phe Val Asn Ala Lys Asp Glu Glu Thr Cys Met Glu Gly Ile Asn Asp 

    450                 455                 460                 





Phe Tyr Arg Thr Cys Lys Leu Leu Gly Ile Asn Met Ser Lys Lys Lys 

465                 470                 475                 480 





Ser Tyr Cys Asn Glu Thr Gly Met Phe Glu Phe Thr Ser Met Phe Tyr 

                485                 490                 495     





Arg Asp Gly Phe Val Ser Asn Phe Ala Met Glu Leu Pro Ser Phe Gly 

            500                 505                 510         





Val Ala Gly Val Asn Glu Ser Ala Asp Met Ala Ile Gly Met Thr Ile 

        515                 520                 525             





Ile Lys Asn Asn Met Ile Asn Asn Gly Met Gly Pro Ala Thr Ala Gln 

    530                 535                 540                 





Thr Ala Ile Gln Leu Phe Ile Ala Asp Tyr Arg Tyr Thr Tyr Lys Cys 

545                 550                 555                 560 





His Arg Gly Asp Ser Lys Val Glu Gly Lys Arg Met Lys Ile Ile Lys 

                565                 570                 575     





Glu Leu Trp Glu Asn Thr Lys Gly Arg Asp Gly Leu Leu Val Ala Asp 

            580                 585                 590         





Gly Gly Pro Asn Leu Tyr Asn Leu Arg Asn Leu His Ile Pro Glu Ile 

        595                 600                 605             





Ile Leu Lys Tyr Asn Ile Met Asp Pro Glu Tyr Lys Gly Arg Leu Leu 

    610                 615                 620                 





His Pro Gln Asn Pro Phe Val Gly His Leu Ser Ile Glu Gly Ile Lys 

625                 630                 635                 640 





Glu Ala Asp Ile Thr Pro Ala His Gly Pro Ile Lys Lys Met Asp Tyr 

                645                 650                 655     





Asp Ala Val Ser Gly Thr His Ser Trp Arg Thr Lys Arg Asn Arg Ser 

            660                 665                 670         





Ile Leu Asn Thr Asp Gln Arg Asn Met Ile Leu Glu Glu Gln Cys Tyr 

        675                 680                 685             





Ala Lys Cys Cys Asn Leu Phe Glu Ala Cys Phe Asn Ser Ala Ser Tyr 

    690                 695                 700                 





Arg Lys Pro Val Gly Gln His Ser Met Leu Glu Ala Met Ala His Arg 

705                 710                 715                 720 





Leu Arg Met Asp Ala Arg Leu Asp Tyr Glu Ser Gly Arg Met Ser Lys 

                725                 730                 735     





Glu Asp Phe Glu Lys Ala Met Ala His Leu Gly Glu Ile Gly Tyr Met 

            740                 745                 750         





<210>  246

<211>  759

<212>  PRT

<213>  Influenza virus



<400>  246



Met Glu Arg Ile Lys Glu Leu Arg Asn Leu Met Ser Gln Ser Arg Thr 

1               5                   10                  15      





Arg Glu Ile Leu Thr Lys Thr Thr Val Asp His Met Ala Ile Ile Lys 

            20                  25                  30          





Lys Tyr Thr Ser Gly Arg Gln Glu Lys Asn Pro Ala Leu Arg Met Lys 

        35                  40                  45              





Trp Met Met Ala Met Lys Tyr Pro Ile Thr Ala Asp Lys Arg Ile Thr 

    50                  55                  60                  





Glu Met Ile Pro Glu Arg Asn Glu Gln Gly Gln Thr Leu Trp Ser Lys 

65                  70                  75                  80  





Met Asn Asp Ala Gly Ser Asp Arg Val Met Val Ser Pro Leu Ala Val 

                85                  90                  95      





Thr Trp Trp Asn Arg Asn Gly Pro Met Thr Asn Thr Val His Tyr Pro 

            100                 105                 110         





Lys Ile Tyr Lys Thr Tyr Phe Glu Arg Val Glu Arg Leu Lys His Gly 

        115                 120                 125             





Thr Phe Gly Pro Val His Phe Arg Asn Gln Val Lys Ile Arg Arg Arg 

    130                 135                 140                 





Val Asp Ile Asn Pro Gly His Ala Asp Leu Ser Ala Lys Glu Ala Gln 

145                 150                 155                 160 





Asp Val Ile Met Glu Val Val Phe Pro Asn Glu Val Gly Ala Arg Ile 

                165                 170                 175     





Leu Thr Ser Glu Ser Gln Leu Thr Ile Thr Lys Glu Lys Lys Glu Glu 

            180                 185                 190         





Leu Gln Asp Cys Lys Ile Ser Pro Leu Met Val Ala Tyr Met Leu Glu 

        195                 200                 205             





Arg Glu Leu Val Arg Lys Thr Arg Phe Leu Pro Val Ala Gly Gly Thr 

    210                 215                 220                 





Ser Ser Val Tyr Ile Glu Val Leu His Leu Thr Gln Gly Thr Cys Trp 

225                 230                 235                 240 





Glu Gln Met Tyr Thr Pro Gly Gly Glu Val Lys Asn Asp Asp Val Asp 

                245                 250                 255     





Gln Ser Leu Ile Ile Ala Ala Arg Asn Ile Val Arg Arg Ala Ala Val 

            260                 265                 270         





Ser Ala Asp Pro Leu Ala Ser Leu Leu Glu Met Cys His Ser Thr Gln 

        275                 280                 285             





Ile Gly Gly Ile Arg Met Val Asp Ile Leu Lys Gln Asn Pro Thr Glu 

    290                 295                 300                 





Glu Gln Ala Val Gly Ile Cys Lys Ala Ala Met Gly Leu Arg Ile Ser 

305                 310                 315                 320 





Ser Ser Phe Ser Phe Gly Gly Phe Thr Phe Lys Arg Thr Ser Gly Ser 

                325                 330                 335     





Ser Val Lys Arg Glu Glu Glu Val Leu Thr Gly Asn Leu Gln Thr Leu 

            340                 345                 350         





Lys Ile Arg Val His Glu Gly Tyr Glu Glu Phe Thr Met Val Gly Arg 

        355                 360                 365             





Arg Ala Thr Ala Ile Leu Arg Lys Ala Thr Arg Arg Leu Ile Gln Leu 

    370                 375                 380                 





Ile Val Ser Gly Arg Asp Glu Gln Ser Ile Ala Glu Ala Ile Ile Val 

385                 390                 395                 400 





Ala Met Val Phe Ser Gln Glu Asp Cys Met Ile Lys Ala Val Arg Gly 

                405                 410                 415     





Asp Leu Asn Phe Val Asn Arg Ala Asn Gln Arg Leu Asn Pro Met His 

            420                 425                 430         





Gln Leu Leu Arg His Phe Gln Lys Asp Ala Lys Val Leu Phe Gln Asn 

        435                 440                 445             





Trp Gly Val Glu Pro Ile Asp Asn Val Met Gly Met Ile Gly Ile Leu 

    450                 455                 460                 





Pro Asp Met Thr Pro Ser Ile Glu Met Ser Met Arg Gly Val Arg Ile 

465                 470                 475                 480 





Ser Lys Met Gly Val Asp Glu Tyr Ser Ser Thr Glu Arg Val Val Val 

                485                 490                 495     





Ser Ile Asp Arg Phe Leu Arg Val Arg Asp Gln Arg Gly Asn Val Leu 

            500                 505                 510         





Leu Ser Pro Glu Glu Val Ser Glu Thr Gln Gly Thr Glu Lys Leu Thr 

        515                 520                 525             





Ile Thr Tyr Ser Ser Ser Met Met Trp Glu Ile Asn Gly Pro Glu Ser 

    530                 535                 540                 





Val Leu Val Asn Thr Tyr Gln Trp Ile Ile Arg Asn Trp Glu Thr Val 

545                 550                 555                 560 





Lys Ile Gln Trp Ser Gln Asn Pro Thr Met Leu Tyr Asn Lys Met Glu 

                565                 570                 575     





Phe Glu Pro Phe Gln Ser Leu Val Pro Lys Ala Ile Arg Gly Gln Tyr 

            580                 585                 590         





Ser Gly Phe Val Arg Thr Leu Phe Gln Gln Met Arg Asp Val Leu Gly 

        595                 600                 605             





Thr Phe Asp Thr Ala Gln Ile Ile Lys Leu Leu Pro Phe Ala Ala Ala 

    610                 615                 620                 





Pro Pro Lys Gln Ser Arg Met Gln Phe Ser Ser Phe Thr Val Asn Val 

625                 630                 635                 640 





Arg Gly Ser Gly Met Arg Ile Leu Val Arg Gly Asn Ser Pro Val Phe 

                645                 650                 655     





Asn Tyr Asn Lys Ala Thr Lys Arg Leu Thr Val Leu Gly Lys Asp Ala 

            660                 665                 670         





Gly Thr Leu Thr Glu Asp Pro Asp Glu Gly Thr Ala Gly Val Glu Ser 

        675                 680                 685             





Ala Val Leu Arg Gly Phe Leu Ile Leu Gly Lys Glu Asp Arg Arg Tyr 

    690                 695                 700                 





Gly Pro Ala Leu Ser Ile Asn Glu Leu Ser Asn Leu Ala Lys Gly Glu 

705                 710                 715                 720 





Lys Ala Asn Val Leu Ile Gly Gln Gly Asp Val Val Leu Val Met Lys 

                725                 730                 735     





Arg Lys Arg Asp Ser Ser Ile Leu Thr Asp Ser Gln Thr Ala Thr Lys 

            740                 745                 750         





Arg Ile Arg Met Ala Ile Asn 

        755                 





<210>  247

<211>  109

<212>  PRT

<213>  Influenza virus



<400>  247



Met Leu Glu Pro Leu Gln Ile Leu Ser Ile Cys Ser Phe Ile Leu Ser 

1               5                   10                  15      





Ala Leu His Phe Met Ala Trp Thr Ile Gly His Leu Asn Gln Ile Lys 

            20                  25                  30          





Arg Gly Val Asn Leu Lys Ile Gln Ile Arg Asn Pro Asn Lys Glu Ala 

        35                  40                  45              





Ile Asn Arg Glu Val Ser Ile Leu Arg His Asn Tyr Gln Lys Glu Ile 

    50                  55                  60                  





Gln Ala Lys Glu Thr Met Lys Lys Ile Leu Ser Asp Asn Met Glu Val 

65                  70                  75                  80  





Leu Gly Asp His Ile Val Val Glu Gly Leu Ser Thr Asp Glu Ile Ile 

                85                  90                  95      





Lys Met Gly Glu Thr Val Leu Glu Val Glu Glu Leu Gln 

            100                 105                 





<210>  248

<211>  100

<212>  PRT

<213>  Influenza virus



<400>  248



Met Asn Asn Ala Thr Phe Asn Cys Thr Asn Ile Asn Pro Ile Thr His 

1               5                   10                  15      





Ile Arg Gly Ser Ile Ile Ile Thr Ile Cys Val Ser Leu Ile Val Ile 

            20                  25                  30          





Leu Ile Val Phe Gly Cys Ile Ala Lys Ile Phe Ile Asn Lys Asn Asn 

        35                  40                  45              





Cys Thr Asn Asn Val Ile Arg Val His Lys Arg Ile Lys Cys Pro Asp 

    50                  55                  60                  





Cys Glu Pro Phe Cys Asn Lys Arg Asp Asp Ile Ser Thr Pro Arg Ala 

65                  70                  75                  80  





Gly Val Asp Ile Pro Ser Phe Ile Leu Pro Gly Leu Asn Leu Ser Glu 

                85                  90                  95      





Gly Thr Pro Asn 

            100 





<210>  249

<211>  498

<212>  PRT

<213>  Influenza virus



<400>  249



Met Ala Ser Gln Gly Thr Lys Arg Ser Tyr Glu Gln Met Glu Thr Asp 

1               5                   10                  15      





Gly Glu Arg Gln Asn Ala Thr Glu Ile Arg Ala Ser Val Gly Lys Met 

            20                  25                  30          





Ile Gly Gly Ile Gly Arg Phe Tyr Ile Gln Met Cys Thr Glu Leu Lys 

        35                  40                  45              





Leu Ser Asp Tyr Glu Gly Arg Leu Ile Gln Asn Ser Leu Thr Ile Glu 

    50                  55                  60                  





Arg Met Val Leu Ser Ala Phe Asp Glu Arg Arg Asn Lys Tyr Leu Glu 

65                  70                  75                  80  





Glu His Pro Ser Ala Gly Lys Asp Pro Lys Lys Thr Gly Gly Pro Ile 

                85                  90                  95      





Tyr Arg Arg Val Asn Gly Lys Trp Met Arg Glu Leu Ile Leu Tyr Asp 

            100                 105                 110         





Lys Glu Glu Ile Arg Arg Ile Trp Arg Gln Ala Asn Asn Gly Asp Asp 

        115                 120                 125             





Ala Thr Ala Gly Leu Thr His Met Met Ile Trp His Ser Asn Leu Asn 

    130                 135                 140                 





Asp Ala Thr Tyr Gln Arg Thr Arg Ala Leu Val Arg Thr Gly Met Asp 

145                 150                 155                 160 





Pro Arg Met Cys Ser Leu Met Gln Gly Ser Thr Leu Pro Arg Arg Ser 

                165                 170                 175     





Gly Ala Ala Gly Ala Ala Val Lys Gly Val Gly Thr Met Val Met Glu 

            180                 185                 190         





Leu Val Arg Met Ile Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg 

        195                 200                 205             





Gly Glu Asn Gly Arg Lys Thr Arg Ile Ala Tyr Glu Arg Met Cys Asn 

    210                 215                 220                 





Ile Leu Lys Gly Lys Phe Gln Thr Ala Ala Gln Lys Ala Met Met Asp 

225                 230                 235                 240 





Gln Val Arg Glu Ser Arg Asp Pro Gly Asn Ala Glu Phe Glu Asp Leu 

                245                 250                 255     





Thr Phe Leu Ala Arg Ser Ala Leu Ile Leu Arg Gly Ser Val Ala His 

            260                 265                 270         





Lys Ser Cys Leu Pro Ala Cys Val Tyr Gly Pro Ala Val Ala Ser Gly 

        275                 280                 285             





Tyr Asp Phe Glu Arg Glu Gly Tyr Ser Leu Val Gly Ile Asp Pro Phe 

    290                 295                 300                 





Arg Leu Leu Gln Asn Ser Gln Val Tyr Ser Leu Ile Arg Pro Asn Glu 

305                 310                 315                 320 





Asn Pro Ala His Lys Ser Gln Leu Val Trp Met Ala Cys His Ser Ala 

                325                 330                 335     





Ala Phe Glu Asp Leu Arg Val Leu Ser Phe Ile Lys Gly Thr Lys Val 

            340                 345                 350         





Val Pro Arg Gly Lys Leu Ser Thr Arg Gly Val Gln Ile Ala Ser Asn 

        355                 360                 365             





Glu Asn Met Glu Thr Met Glu Ser Ser Thr Leu Glu Leu Arg Ser Arg 

    370                 375                 380                 





Tyr Trp Ala Ile Arg Thr Arg Ser Gly Gly Asn Thr Asn Gln Gln Arg 

385                 390                 395                 400 





Ala Ser Ala Gly Gln Ile Ser Ile Gln Pro Thr Phe Ser Val Gln Arg 

                405                 410                 415     





Asn Leu Pro Phe Asp Arg Thr Thr Val Met Ala Ala Phe Thr Gly Asn 

            420                 425                 430         





Thr Glu Gly Arg Thr Ser Asp Met Arg Thr Glu Ile Ile Arg Met Met 

        435                 440                 445             





Glu Ser Ala Arg Pro Glu Asp Val Ser Phe Gln Gly Arg Gly Val Phe 

    450                 455                 460                 





Glu Leu Ser Asp Glu Lys Ala Ala Ser Pro Ile Val Pro Ser Phe Asp 

465                 470                 475                 480 





Met Ser Asn Glu Gly Ser Tyr Phe Phe Gly Asp Asn Ala Glu Glu Tyr 

                485                 490                 495     





Asp Asn 

        





<210>  250

<211>  551

<212>  PRT

<213>  Human herpesvirus 5



<400>  250



Met Ala Ser Val Leu Gly Pro Ile Ser Gly His Val Leu Lys Ala Val 

1               5                   10                  15      





Phe Ser Arg Gly Asp Thr Pro Val Leu Pro His Glu Thr Arg Leu Leu 

            20                  25                  30          





Gln Thr Gly Ile His Val Arg Val Ser Gln Pro Ser Leu Ile Leu Val 

        35                  40                  45              





Ser Gln Tyr Thr Pro Asp Ser Thr Pro Cys His Arg Gly Asp Asn Gln 

    50                  55                  60                  





Leu Gln Val Gln His Thr Tyr Phe Thr Gly Ser Glu Val Glu Asn Val 

65                  70                  75                  80  





Ser Val Asn Val His Asn Pro Thr Gly Arg Ser Ile Cys Pro Ser Gln 

                85                  90                  95      





Glu Pro Met Ser Ile Tyr Val Tyr Ala Leu Pro Leu Lys Met Leu Asn 

            100                 105                 110         





Ile Pro Ser Ile Asn Val His His Tyr Pro Ser Ala Ala Glu Arg Lys 

        115                 120                 125             





His Arg His Leu Pro Val Ala Asp Ala Val Ile His Ala Ser Gly Lys 

    130                 135                 140                 





Gln Met Trp Gln Ala Arg Leu Thr Val Ser Gly Leu Ala Trp Thr Arg 

145                 150                 155                 160 





Gln Gln Asn Gln Trp Lys Glu Pro Asp Val Tyr Tyr Thr Ser Ala Phe 

                165                 170                 175     





Val Phe Pro Thr Lys Asp Val Ala Leu Arg His Val Val Cys Ala His 

            180                 185                 190         





Glu Leu Val Cys Ser Met Glu Asn Thr Arg Ala Thr Lys Met Gln Val 

        195                 200                 205             





Ile Gly Asp Gln Tyr Val Lys Val Tyr Leu Glu Ser Phe Cys Glu Asp 

    210                 215                 220                 





Val Pro Ser Gly Lys Leu Phe Met His Val Thr Leu Gly Ser Asp Val 

225                 230                 235                 240 





Glu Glu Asp Leu Thr Met Thr Arg Asn Pro Gln Pro Phe Met Arg Pro 

                245                 250                 255     





His Glu Arg Asn Gly Phe Thr Val Leu Cys Pro Lys Asn Met Ile Ile 

            260                 265                 270         





Lys Pro Gly Lys Ile Ser His Ile Met Leu Asp Val Ala Phe Thr Ser 

        275                 280                 285             





His Glu His Phe Gly Leu Leu Cys Pro Lys Ser Ile Pro Gly Leu Ser 

    290                 295                 300                 





Ile Ser Gly Asn Leu Leu Met Asn Gly Gln Gln Ile Phe Leu Glu Val 

305                 310                 315                 320 





Gln Ala Ile Arg Glu Thr Val Glu Leu Arg Gln Tyr Asp Pro Val Ala 

                325                 330                 335     





Ala Leu Phe Phe Phe Asp Ile Asp Leu Leu Leu Gln Arg Gly Pro Gln 

            340                 345                 350         





Tyr Ser Glu His Pro Thr Phe Thr Ser Gln Tyr Arg Ile Gln Gly Lys 

        355                 360                 365             





Leu Glu Tyr Arg His Thr Trp Asp Arg His Asp Glu Gly Ala Ala Gln 

    370                 375                 380                 





Gly Asp Asp Asp Val Trp Thr Ser Gly Ser Asp Ser Asp Glu Glu Leu 

385                 390                 395                 400 





Val Thr Thr Glu Arg Lys Thr Pro Arg Val Thr Gly Gly Gly Ala Met 

                405                 410                 415     





Ala Gly Ala Ser Thr Ser Ala Gly Arg Lys Arg Lys Ser Ala Ser Ser 

            420                 425                 430         





Ala Thr Ala Cys Thr Ala Gly Val Met Thr Arg Gly Arg Leu Lys Ala 

        435                 440                 445             





Glu Ser Thr Val Ala Pro Glu Glu Asp Thr Asp Glu Asp Ser Asp Asn 

    450                 455                 460                 





Glu Ile His Asn Pro Ala Val Phe Thr Trp Pro Pro Trp Gln Ala Gly 

465                 470                 475                 480 





Ile Leu Ala Arg Asn Leu Val Pro Met Val Ala Thr Val Gln Gly Gln 

                485                 490                 495     





Asn Leu Lys Tyr Gln Glu Phe Phe Trp Asp Ala Asn Asp Ile Tyr Arg 

            500                 505                 510         





Ile Phe Ala Glu Leu Glu Gly Val Trp Gln Pro Ala Ala Gln Pro Lys 

        515                 520                 525             





Arg Arg Arg His Arg Gln Asp Ala Leu Pro Gly Pro Cys Ile Ala Ser 

    530                 535                 540                 





Thr Pro Lys Lys His Arg Gly 

545                 550     





<210>  251

<211>  551

<212>  PRT

<213>  Human herpesvirus 5



<400>  251



Met Ala Ser Val Leu Gly Pro Ile Ser Gly His Val Leu Lys Ala Val 

1               5                   10                  15      





Phe Ser Arg Gly Asp Thr Pro Val Leu Pro His Glu Thr Arg Leu Leu 

            20                  25                  30          





Gln Thr Gly Ile His Val Arg Val Ser Gln Pro Ser Leu Ile Leu Val 

        35                  40                  45              





Ser Gln Tyr Thr Pro Asp Ser Thr Pro Cys His Arg Gly Asp Asn Gln 

    50                  55                  60                  





Leu Gln Val Gln His Thr Tyr Phe Thr Gly Ser Glu Val Glu Asn Val 

65                  70                  75                  80  





Ser Val Asn Val His Asn Pro Thr Gly Arg Ser Ile Cys Pro Ser Gln 

                85                  90                  95      





Glu Pro Met Ser Ile Tyr Val Tyr Ala Leu Pro Leu Lys Met Leu Asn 

            100                 105                 110         





Ile Pro Ser Ile Asn Val His His Tyr Pro Ser Ala Ala Glu Arg Lys 

        115                 120                 125             





His Arg His Leu Pro Val Ala Asp Ala Val Ile His Ala Ser Gly Lys 

    130                 135                 140                 





Gln Met Trp Gln Ala Arg Leu Thr Val Ser Gly Leu Ala Trp Thr Arg 

145                 150                 155                 160 





Gln Gln Asn Gln Trp Lys Glu Pro Asp Val Tyr Tyr Thr Ser Ala Phe 

                165                 170                 175     





Val Phe Pro Thr Lys Asp Val Ala Leu Arg His Val Val Cys Ala His 

            180                 185                 190         





Glu Leu Val Cys Ser Met Glu Asn Thr Arg Ala Thr Lys Met Gln Val 

        195                 200                 205             





Ile Gly Asp Gln Tyr Val Lys Val Tyr Leu Glu Ser Phe Cys Glu Asp 

    210                 215                 220                 





Val Pro Ser Gly Lys Leu Phe Met His Val Thr Leu Gly Ser Asp Val 

225                 230                 235                 240 





Glu Glu Asp Leu Thr Met Thr Arg Asn Pro Gln Pro Phe Met Arg Pro 

                245                 250                 255     





His Glu Arg Asn Gly Phe Thr Val Leu Cys Pro Lys Asn Met Ile Ile 

            260                 265                 270         





Lys Pro Gly Lys Ile Ser His Ile Met Leu Asp Val Ala Phe Thr Ser 

        275                 280                 285             





His Glu His Phe Gly Leu Leu Cys Pro Lys Ser Ile Pro Gly Leu Ser 

    290                 295                 300                 





Ile Ser Gly Asn Leu Leu Met Asn Gly Gln Gln Ile Phe Leu Glu Val 

305                 310                 315                 320 





Gln Ala Ile Arg Glu Thr Val Glu Leu Arg Gln Tyr Asp Pro Val Ala 

                325                 330                 335     





Ala Leu Phe Phe Phe Asp Ile Asp Leu Leu Leu Gln Arg Gly Pro Gln 

            340                 345                 350         





Tyr Ser Glu His Pro Thr Phe Thr Ser Gln Tyr Arg Ile Gln Gly Lys 

        355                 360                 365             





Leu Glu Tyr Arg His Thr Trp Asp Arg His Asp Glu Gly Ala Ala Gln 

    370                 375                 380                 





Gly Asp Asp Asp Val Trp Thr Ser Gly Ser Asp Ser Asp Glu Glu Leu 

385                 390                 395                 400 





Val Thr Thr Glu Arg Lys Thr Pro Arg Val Thr Gly Gly Gly Ala Met 

                405                 410                 415     





Ala Gly Ala Ser Thr Ser Ala Gly Arg Lys Arg Lys Ser Ala Ser Ser 

            420                 425                 430         





Ala Thr Ala Cys Thr Ala Gly Val Met Thr Arg Gly Arg Leu Lys Ala 

        435                 440                 445             





Glu Ser Thr Val Ala Pro Glu Glu Asp Thr Asp Glu Asp Ser Asp Asn 

    450                 455                 460                 





Glu Ile His Asn Pro Ala Val Phe Thr Trp Pro Pro Trp Gln Ala Gly 

465                 470                 475                 480 





Ile Leu Ala Arg Asn Leu Val Pro Met Val Ala Thr Val Gln Gly Gln 

                485                 490                 495     





Asn Leu Lys Tyr Gln Glu Phe Phe Trp Asp Ala Asn Asp Ile Tyr Arg 

            500                 505                 510         





Ile Phe Ala Glu Leu Glu Gly Val Trp Gln Pro Ala Ala Gln Pro Lys 

        515                 520                 525             





Arg Arg Arg His Arg Gln Asp Ala Leu Pro Gly Pro Cys Ile Ala Ser 

    530                 535                 540                 





Thr Pro Lys Lys His Arg Gly 

545                 550     





<210>  252

<211>  9

<212>  PRT

<213>  Hepatitis B virus





<220>

<221>  MISC_FEATURE

<223>  Amino acid sequence encoding HBV pre-S protein 85-66



<400>  252



Ser Thr Asn Arg Gln Ser Gly Arg Gln 

1               5                   





<210>  253

<211>  9

<212>  PRT

<213>  Human T-cell lymphotropic virus 1





<220>

<221>  MISC_FEATURE

<223>  HTLV-1 tax 11-19



<400>  253



Leu Leu Phe Gly Tyr Pro Val Tyr Val 

1               5                   





<210>  254

<211>  10

<212>  PRT

<213>  Hepatitis B virus





<220>

<221>  MISC_FEATURE

<223>  HBV surface antigen 185-194



<400>  254



Gly Leu Ser Pro Thr Val Trp Leu Ser Val 

1               5                   10  





<210>  255

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  255



Met Asn Ile Leu Leu Gln Tyr Val Val Lys Ser Phe Asp 

1               5                   10              





<210>  256

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  256



Ile Ala Pro Val Phe Val Leu Leu Glu 

1               5                   





<210>  257

<211>  14

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  257



Leu Pro Arg Leu Ile Ala Phe Thr Ser Glu His Ser His Phe 

1               5                   10                  





<210>  258

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  258



Ile Ala Phe Thr Ser Glu His Ser His Phe Ser Leu Lys 

1               5                   10              





<210>  259

<211>  14

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  259



Thr Val Tyr Gly Ala Phe Asp Pro Leu Leu Ala Val Ala Asp 

1               5                   10                  





<210>  260

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  260



Lys Tyr Lys Ile Trp Met His Val Asp Ala Ala Trp Gly Gly Gly 

1               5                   10                  15  





<210>  261

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  261



Lys His Lys Trp Lys Leu Ser Gly Val Glu Arg Ala Asn Ser Val 

1               5                   10                  15  





<210>  262

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  262



Leu Tyr Asn Ile Ile Lys Asn Arg Glu Gly Tyr Glu Met Val Phe 

1               5                   10                  15  





<210>  263

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  263



Pro Ser Leu Arg Thr Leu Glu Asp Asn Glu Glu Arg Met Ser Arg 

1               5                   10                  15  





<210>  264

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  264



Arg Met Met Glu Tyr Gly Thr Thr Met Val Ser Tyr Gln Pro Leu 

1               5                   10                  15  





<210>  265

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  265



Ser Tyr Gln Pro Leu Gly Asp Lys Val Asn Phe Phe Arg Met Val 

1               5                   10                  15  





<210>  266

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  266



Asn Phe Phe Arg Met Val Ile Ser Asn Pro Ala Ala Thr 

1               5                   10              





<210>  267

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  267



Ala Thr His Gln Asp Ile Asp Phe Leu Ile Glu Glu Ile Glu Arg 

1               5                   10                  15  





<210>  268

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  268



Ala Thr Asp Leu Leu Pro Ala Cys Asp 

1               5                   





<210>  269

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  269



Phe Asp Arg Ser Thr Lys Val Ile Asp Phe His Tyr Pro Asn Glu 

1               5                   10                  15  





<210>  270

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  270



Glu Leu Leu Gln Glu Tyr Asn Trp Glu 

1               5                   





<210>  271

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  271



Glu Tyr Asn Trp Glu Leu Ala Asp Gln 

1               5                   





<210>  272

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  272



Asp Ile Asp Phe Leu Ile Glu Glu Ile 

1               5                   





<210>  273

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  273



Thr Gly His Pro Arg Tyr Phe Asn Gln Leu Ser Thr Gly Leu Asp 

1               5                   10                  15  





<210>  274

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  274



Thr Tyr Glu Ile Ala Pro Val Phe Val Leu Leu Glu Tyr Val Thr 

1               5                   10                  15  





<210>  275

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  275



Tyr Val Thr Leu Lys Lys Met Arg Glu 

1               5                   





<210>  276

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  276



Pro Gly Gly Ser Gly Asp Gly Ile Phe Ser Pro Gly Gly Ala Ile Ser 

1               5                   10                  15      





Asn Met Tyr Ala 

            20  





<210>  277

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  277



Asn Met Tyr Ala Met Met Ile Ala Arg Phe Lys Met Phe Pro Glu Val 

1               5                   10                  15      





Lys Glu Lys Gly 

            20  





<210>  278

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  278



Pro Glu Val Lys Glu Lys Gly Met Ala Ala Leu Pro Arg Leu Ile Ala 

1               5                   10                  15      





Phe Thr Ser Glu 

            20  





<210>  279

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  279



Asp Ser Val Ile Leu Ile Lys Cys Asp 

1               5                   





<210>  280

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  280



Gly Lys Met Ile Pro Ser Asp Leu Glu 

1               5                   





<210>  281

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  281



Glu Arg Arg Ile Leu Glu Ala Lys Gln 

1               5                   





<210>  282

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  282



Glu Arg Ala Asn Ser Val Thr Trp Asn 

1               5                   





<210>  283

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  283



Gln Cys Ser Ala Leu Leu Val Arg Glu 

1               5                   





<210>  284

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  284



Lys His Tyr Asp Leu Ser Tyr Asp Thr Gly Asp Lys Ala Leu Gln 

1               5                   10                  15  





<210>  285

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  285



Ala Lys Gly Thr Thr Gly Phe Glu Ala His Val Asp Lys Cys Leu 

1               5                   10                  15  





<210>  286

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  286



Val Asp Lys Cys Leu Glu Leu Ala Glu Tyr Leu Tyr Asn Ile Ile Lys 

1               5                   10                  15      





Asn Arg Glu Gly 

            20  





<210>  287

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  287



Ile Ile Lys Asn Arg Glu Gly Tyr Glu 

1               5                   





<210>  288

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  288



Met Val Phe Asp Gly Lys Pro Gln His Thr Asn Val Cys Phe Trp 

1               5                   10                  15  





<210>  289

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  289



Cys Phe Trp Tyr Ile Pro Pro Ser Leu Arg Thr Leu Glu Asp Asn 

1               5                   10                  15  





<210>  290

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  290



Phe Trp Tyr Ile Pro Pro Ser Leu Arg Thr Leu Glu Asp 

1               5                   10              





<210>  291

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  291



Ser Leu Arg Thr Leu Glu Asp Asn Glu 

1               5                   





<210>  292

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  292



Glu Arg Met Ser Arg Leu Ser Lys Val Ala Pro Val Ile Lys Ala 

1               5                   10                  15  





<210>  293

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  293



Ile Lys Ala Arg Met Met Glu Tyr Gly Thr Thr Met Val Ser Tyr 

1               5                   10                  15  





<210>  294

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  294



Arg Met Met Glu Tyr Gly Thr Thr Met Val Ser Tyr Gln Pro Leu 

1               5                   10                  15  





<210>  295

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  295



Val Ile Ser Asn Pro Ala Ala Thr His 

1               5                   





<210>  296

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  296



Ile Asp Phe Leu Ile Glu Glu Ile Glu 

1               5                   





<210>  297

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  297



Asn Trp Glu Leu Ala Asp Gln Pro Gln Asn Leu Glu Glu Ile Leu Met 

1               5                   10                  15      





His Cys Gln Thr 

            20  





<210>  298

<211>  12

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  298



Gly His Pro Arg Tyr Phe Asn Gln Leu Ser Thr Gly 

1               5                   10          





<210>  299

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  299



Thr Tyr Glu Ile Ala Pro Val Phe Val Leu Leu Phe Tyr Val Thr Leu 

1               5                   10                  15      





Lys Lys Met Arg 

            20  





<210>  300

<211>  17

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  300



Val Asn Phe Phe Arg Met Val Ile Ser Asn Pro Ala Ala Thr His Gln 

1               5                   10                  15      





Asp 

    





<210>  301

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  301



Asp Lys Val Asn Phe Phe Arg Met Val Ile Ser Asn Pro Ala Ala Thr 

1               5                   10                  15      





His Gln Asp Ile Asp 

            20      





<210>  302

<211>  10

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  302



Phe Phe Arg Met Val Ile Ser Asn Pro Ala 

1               5                   10  





<210>  303

<211>  14

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  303



Leu Thr Ile Gln Ile Glu Ser Ala Ala Asp Gln Asp Pro Ser 

1               5                   10                  





<210>  304

<211>  14

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  304



Arg Thr Gly Ile Ala Gln Ala Leu Ser Ser Phe Asp Leu His 

1               5                   10                  





<210>  305

<211>  14

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  305



Leu Tyr Pro Asp Tyr Gln Ile Gln Ala Gly Ile Met Ile Thr 

1               5                   10                  





<210>  306

<211>  14

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  306



Ile Leu Ser Val His Val Ala Thr Ala Ala Ser Gln Asp Ser 

1               5                   10                  





<210>  307

<211>  14

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  307



Ser Lys Arg Leu Thr Phe Gly Trp Tyr Arg Ala Glu Ile Leu 

1               5                   10                  





<210>  308

<211>  14

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  308



Ala Ile Leu Thr Asp Ala Ala His Leu Leu Ile Asp Leu Thr 

1               5                   10                  





<210>  309

<211>  14

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  309



Lys Ala Thr Gly Asn Arg Ser Ser Lys Gln Ala His Ala Lys 

1               5                   10                  





<210>  310

<211>  14

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  310



Ala Val Asp Gly Val Ile Ser Val His Ser Leu His Ile Trp 

1               5                   10                  





<210>  311

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  311



Val Ser Ser Val Ser Ser Gln Phe Ser Asp Ala Ala Gln Ala Ser Pro 

1               5                   10                  15      





Ser Ser Phe Ser Asp 

            20      





<210>  312

<211>  24

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  312



Leu Ala Lys Glu Trp Gln Ala Leu Cys Ala Tyr Gln Ala Glu Pro Asn 

1               5                   10                  15      





Thr Cys Ala Thr Ala Gln Gly Glu 

            20                  





<210>  313

<211>  24

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  313



Lys Leu Lys Val Glu Ser Ser Pro Ser Arg Ser Asp Tyr Ile Asn Ala 

1               5                   10                  15      





Ser Pro Ile Ile Glu His Asp Pro 

            20                  





<210>  314

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  314



Ile Lys Leu Lys Val Glu Ser Ser Pro Ser Arg Ser Asp Tyr Ile Asn 

1               5                   10                  15      





Ala Ser Pro Ile 

            20  





<210>  315

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  315



Met Val Trp Glu Ser Gly Cys Thr Val Ile Val Met Leu Thr Pro Leu 

1               5                   10                  15      





Val Glu Asp Gly Val 

            20      





<210>  316

<211>  18

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  316



Arg Gln His Ala Arg Gln Gln Asp Lys Glu Arg Leu Ala Ala Leu Gly 

1               5                   10                  15      





Pro Glu 

        





<210>  317

<211>  18

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  317



Gly Pro Glu Gly Ala His Gly Asp Thr Thr Phe Glu Tyr Gln Asp Leu 

1               5                   10                  15      





Cys Arg 

        





<210>  318

<211>  18

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  318



Glu Gly Pro Pro Glu Pro Ser Arg Val Ser Ser Val Ser Ser Gln Phe 

1               5                   10                  15      





Ser Asp 

        





<210>  319

<211>  18

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  319



Phe Ser Asp Ala Ala Gln Ala Ser Pro Ser Ser His Ser Ser Thr Pro 

1               5                   10                  15      





Ser Trp 

        





<210>  320

<211>  18

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  320



Ala Glu Pro Asn Thr Cys Ala Thr Ala Gln Gly Glu Gly Asn Ile Lys 

1               5                   10                  15      





Lys Asn 

        





<210>  321

<211>  18

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  321



Asn Ala Ser Pro Ile Ile Glu His Asp Pro Arg Met Pro Ala Tyr Ile 

1               5                   10                  15      





Ala Thr 

        





<210>  322

<211>  18

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  322



Asp Glu Gly Ser Ala Leu Tyr His Val Tyr Glu Val Asn Leu Val Ser 

1               5                   10                  15      





Glu His 

        





<210>  323

<211>  17

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  323



Lys Gly Val Lys Glu Ile Asp Ile Ala Ala Thr Leu Glu His Val Arg 

1               5                   10                  15      





Asp 

    





<210>  324

<211>  19

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  324



Phe Ala Leu Thr Ala Val Ala Glu Glu Val Asn Ala Ile Leu Lys Ala 

1               5                   10                  15      





Leu Pro Gln 

            





<210>  325

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  325



Lys Asn Arg Ser Leu Ala Val Leu Thr Tyr Asp His Ser Arg Ile 

1               5                   10                  15  





<210>  326

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  326



Gly Ala Asp Pro Ser Ala Asp Ala Thr Glu Ala Tyr Gln Glu Leu 

1               5                   10                  15  





<210>  327

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  327



Glu Ile Asp Ile Ala Ala Thr Leu Glu 

1               5                   





<210>  328

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  328



Asn Thr Cys Ala Thr Ala Gln Gly Glu 

1               5                   





<210>  329

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  329



Glu Pro Asn Thr Cys Ala Thr Ala Gln 

1               5                   





<210>  330

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  330



Glu Arg Leu Ala Ala Leu Gly Pro Glu 

1               5                   





<210>  331

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  331



Gln His Ala Arg Gln Gln Asp Lys Glu 

1               5                   





<210>  332

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  332



Tyr Glu Val Asn Leu Val Ser Glu His 

1               5                   





<210>  333

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  333



Gly Ala Ser Leu Tyr His Val Tyr Glu 

1               5                   





<210>  334

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  334



Phe Ala Leu Thr Ala Val Ala Glu Glu 

1               5                   





<210>  335

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  335



Gly Ala His Gly Asp Thr Thr Phe Glu 

1               5                   





<210>  336

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  336



Gly Asp Thr Thr Phe Glu Tyr Gln Asp 

1               5                   





<210>  337

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  337



Ala Ala Gln Ala Ser Pro Ser Ser His 

1               5                   





<210>  338

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  338



Ser Arg Val Ser Ser Val Ser Ser Gln 

1               5                   





<210>  339

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  339



Thr Gln Phe His Phe Leu Ser Trp Pro 

1               5                   





<210>  340

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  340



Glu Glu Pro Ala Gln Ala Asn Met Asp 

1               5                   





<210>  341

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  341



Gly His Met Ile Leu Ala Tyr Met Glu 

1               5                   





<210>  342

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  342



Met Ile Leu Ala Tyr Met Glu Asp His 

1               5                   





<210>  343

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  343



Gln Ala Leu Cys Ala Tyr Gln Ala Glu 

1               5                   





<210>  344

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  344



Glu Trp Gln Ala Leu Cys Ala Tyr Gln 

1               5                   





<210>  345

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  345



Leu Val Arg Ser Lys Asp Gln Phe Glu 

1               5                   





<210>  346

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  346



Val Glu Asp Gly Val Lys Gln Cys Asp 

1               5                   





<210>  347

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  347



Tyr Ile Leu Ile Asp Met Val Leu Asn 

1               5                   





<210>  348

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  348



Glu Ser Gly Cys Thr Val Ile Val Met 

1               5                   





<210>  349

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  349



Leu Cys Ala Tyr Gln Ala Glu Pro Asn 

1               5                   





<210>  350

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  350



Glu Thr Arg Thr Leu Thr Gln Phe His 

1               5                   





<210>  351

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  351



Val Glu Ser Ser Pro Ser Arg Ser Asp 

1               5                   





<210>  352

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  352



Gly Pro Leu Ser His Thr Ile Ala Asp 

1               5                   





<210>  353

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  353



Ser Leu Phe Asn Arg Ala Glu Gly Pro 

1               5                   





<210>  354

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  354



His Pro Asp Phe Leu Pro Tyr Asp His 

1               5                   





<210>  355

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  355



His Phe Leu Ser Trp Pro Ala Glu Gly 

1               5                   





<210>  356

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  356



Asp Phe Arg Arg Lys Val Asn Lys Cys 

1               5                   





<210>  357

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  357



His Cys Ser Asp Gly Ala Gly Arg Thr 

1               5                   





<210>  358

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  358



Leu Val Arg Ser Phe Tyr Leu Lys Asn 

1               5                   





<210>  359

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  359



Lys Asn Arg Ser Leu Ala Val Leu Thr Tyr Asp His Ser Arg Ile 

1               5                   10                  15  





<210>  360

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  360



Gly Ala Asp Pro Ser Ala Asp Ala Thr Glu Ala Tyr Gln Glu Leu 

1               5                   10                  15  





<210>  361

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  361



Ala Asn Met Asp Ile Ser Thr Gly His Met Ile Leu Ala Tyr Met Glu 

1               5                   10                  15      





<210>  362

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  362



Trp Gln Ala Leu Cys Ala Tyr Gln Ala Glu Pro Asn Thr Cys Ala Thr 

1               5                   10                  15      





<210>  363

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  363



Leu Ser His Thr Ile Ala Asp Phe Trp Gln Met Val Trp Glu Ser Gly 

1               5                   10                  15      





<210>  364

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  364



Asp Phe Trp Gln Met Val Trp Glu Ser Gly Cys Thr Val Ile Val Met 

1               5                   10                  15      





<210>  365

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  365



Trp Glu Ser Gly Cys Thr Val Ile Val Met Leu Thr Pro Leu Val Glu 

1               5                   10                  15      





<210>  366

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  366



Val Ile Val Met Leu Thr Pro Leu Val Glu Asp Gly Val Lys Gln Cys 

1               5                   10                  15      





<210>  367

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  367



Ser Glu His Ile Trp Cys Glu Asp Phe Leu Val Arg Ser Phe Tyr Leu 

1               5                   10                  15      





<210>  368

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  368



Trp Cys Glu Asp Phe Leu Val Arg Ser Phe Tyr Leu Lys Asn Val Gln 

1               5                   10                  15      





<210>  369

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  369



Glu Asp Phe Leu Val Arg Ser Phe Tyr Leu Lys Asn Val Gln Thr Gln 

1               5                   10                  15      





<210>  370

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  370



Asp Phe Arg Arg Lys Val Asn Lys Cys Tyr Arg Gly Arg Ser Cys Pro 

1               5                   10                  15      





<210>  371

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  371



Tyr Ile Leu Ile Asp Met Val Leu Asn Arg Met Ala Lys Gly Val Lys 

1               5                   10                  15      





<210>  372

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  372



Phe Glu Phe Ala Leu Thr Ala Val Ala Glu Glu Val Asn Ala Ile Leu 

1               5                   10                  15      





<210>  373

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  373



Glu Ala Leu Tyr Leu Val Cys Gly Glu 

1               5                   





<210>  374

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  374



Ser Ile Cys Ser Leu Tyr Gln Leu Glu 

1               5                   





<210>  375

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  375



Ala Leu Leu Ala Leu Trp Gly Pro Asp 

1               5                   





<210>  376

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  376



Gly Ser Leu Gln Pro Leu Ala Leu Glu 

1               5                   





<210>  377

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  377



Thr Pro Lys Thr Arg Arg Glu Ala Glu 

1               5                   





<210>  378

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  378



Pro Ala Ala Ala Phe Val Asn Gln His 

1               5                   





<210>  379

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  379



Asp Pro Ala Ala Ala Phe Val Asn Gln 

1               5                   





<210>  380

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  380



Pro Asp Pro Ala Ala Ala Phe Val Asn 

1               5                   





<210>  381

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  381



Gln Lys Arg Gly Ile Val Glu Gln Cys 

1               5                   





<210>  382

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  382



Glu Leu Gly Gly Gly Pro Gly Ala Gly 

1               5                   





<210>  383

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  383



Glu Ala Glu Asp Leu Gln Val Gly Gln 

1               5                   





<210>  384

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  384



Leu Gln Val Gly Gln Val Glu Leu Gly 

1               5                   





<210>  385

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  385



His Leu Cys Gly Ser His Leu Val Glu 

1               5                   





<210>  386

<211>  12

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  386



Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser 

1               5                   10          





<210>  387

<211>  14

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  387



Lys Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser 

1               5                   10                  





<210>  388

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  388



Leu Ala Leu Leu Ala Leu Trp Gly Pro Asp Pro Ala Ala Ala Phe Val 

1               5                   10                  15      





<210>  389

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  389



Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val 

1               5                   10                  15      





<210>  390

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  390



Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly 

1               5                   10                  15  





<210>  391

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  391



Phe Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp 

1               5                   10              





<210>  392

<211>  18

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  392



Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys 

1               5                   10                  15      





Arg Gly 

        





<210>  393

<211>  17

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  393



Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys 

1               5                   10                  15      





Ser 

    





<210>  394

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  394



Lys Phe Gly Ala Asp Ala Arg Ala Leu Met Leu Gln Gly Val Asp Leu 

1               5                   10                  15      





Leu Ala Asp Ala 

            20  





<210>  395

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  395



Asn Pro Val Glu Ile Arg Arg Gly Val Met Leu Ala Val Asp Ala Val 

1               5                   10                  15      





Ile Ala Glu Leu 

            20  





<210>  396

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  396



Gln Ser Ile Val Pro Ala Leu Glu Ile Ala Asn Ala His Arg Lys Pro 

1               5                   10                  15      





Leu Val Ile Ile Ala 

            20      





<210>  397

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  397



Leu Val Leu Asn Arg Leu Lys Val Gly Leu Gln Val Val Ala Val Lys 

1               5                   10                  15      





Ala Pro Gly Phe 

            20  





<210>  398

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  398



Ile Val Leu Gly Gly Gly Cys Ala Leu Leu Arg Cys Ile Pro Ala Leu 

1               5                   10                  15      





Asp Ser Leu Thr 

            20  





<210>  399

<211>  24

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  399



Val Leu Gly Gly Gly Cys Ala Leu Leu Arg Cys Ile Pro Ala Leu Asp 

1               5                   10                  15      





Ser Leu Thr Pro Ala Asn Glu Asp 

            20                  





<210>  400

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  400



Glu Ile Ile Lys Arg Thr Leu Lys Ile Pro Ala Met Thr Ile Ala Lys 

1               5                   10                  15      





Asn Ala Gly Val 

            20  





<210>  401

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  401



Val Asn Met Val Glu Lys Gly Ile Ile Asp Pro Thr Lys Val Val Arg 

1               5                   10                  15      





Thr Ala Leu Leu 

            20  





<210>  402

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  402



Met Ala Lys Ala Ala Ala Val Gly Ile Asp Leu Gly Thr Thr Tyr Ser 

1               5                   10                  15      





Cys Val Gly Val 

            20  





<210>  403

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  403



Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro Thr Ala Ala Ala Ile 

1               5                   10                  15      





Ala Tyr Gly Leu 

            20  





<210>  404

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  404



Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr Ala Gly Asp Thr 

1               5                   10                  15      





His Leu Gly Gly 

            20  





<210>  405

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  405



Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val Asn His Phe 

1               5                   10                  15      





Val Glu Glu Phe 

            20  





<210>  406

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  406



Lys Arg Thr Leu Ser Ser Ser Thr Gln Ala Ser Leu Glu Ile Asp Ser 

1               5                   10                  15      





Leu Phe Glu Gly 

            20  





<210>  407

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  407



Leu Leu Leu Leu Asp Val Ala Pro Leu Ser Leu Gly Leu Glu Thr Ala 

1               5                   10                  15      





Gly Gly Val Met 

            20  





<210>  408

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  408



Pro Thr Lys Gln Thr Gln Ile Phe Thr Thr Tyr Ser Asp Asn Gln Pro 

1               5                   10                  15      





Gly Val Leu Ile 

            20  





<210>  409

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  409



Lys Ala Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 

1               5                   10                  15      





Glu Glu Ile Glu 

            20  





<210>  410

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  410



Lys Glu Glu Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala 

1               5                   10                  15      





Glu Asp Glu Val 

            20  





<210>  411

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  411



Gln His Leu Gln Lys Asp Tyr Arg Ala Tyr Tyr Thr Phe 

1               5                   10              





<210>  412

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  412



Arg Val Leu Asn Ile Asp Leu Leu Trp Ser Val Pro Ile 

1               5                   10              





<210>  413

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  413



Tyr Thr Phe Leu Asn Phe Met Ser Asn Val Gly Asp Pro 

1               5                   10              





<210>  414

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  414



Asp Trp Ile His Ile Asp Thr Thr Pro Phe Ala Gly Leu 

1               5                   10              





<210>  415

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  415



Arg Ser Gln Pro Gly Leu Cys Asn Met Tyr Lys Asp Ser His His Pro 

1               5                   10                  15      





Ala Arg Thr Ala 

            20  





<210>  416

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  416



Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe Lys Leu 

1               5                   10                  15      





Gly Gly Arg Asp Ser 

            20      





<210>  417

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  417



Gly Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Val Pro Trp Leu 

1               5                   10                  15      





Lys Pro Gly Arg Ser 

            20      





<210>  418

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  418



Arg Ser Gln Pro Gly Leu Cys Asn Met Tyr Lys Asp Ser His His Pro 

1               5                   10                  15      





Ala Arg Thr Ala 

            20  





<210>  419

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  419



Ser Asp Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val Asp Ala Gln 

1               5                   10                  15      





Gly Thr Leu Ser Lys 

            20      





<210>  420

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  420



Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe Lys Leu 

1               5                   10                  15      





Gly Gly Arg Asp Ser 

            20      





<210>  421

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  421



Ser Asp Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val Asp Ala Gln 

1               5                   10                  15      





Gly Thr Leu Ser Lys 

            20      





<210>  422

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  422



Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg 

1               5                   10                  15  





<210>  423

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  423



Val Phe Ala Cys Ser Ala Val Pro Val Tyr Ile Tyr Phe Asn Thr Trp 

1               5                   10                  15      





Thr Thr Cys Gln Ser 

            20      





<210>  424

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  424



Tyr Ile Tyr Phe Asn Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro 

1               5                   10                  15      





Ser Lys Thr Ser Ala 

            20      





<210>  425

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  425



Ala His Ser Leu Glu Arg Val Cys His Cys Leu Gly Lys Trp Leu Gly 

1               5                   10                  15      





His Pro Asp Lys Phe 

            20      





<210>  426

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  426



Ala Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys 

1               5                   10                  15      





Gly Leu Ser Ala Thr 

            20      





<210>  427

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  427



Phe Met Ile Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly 

1               5                   10                  15      





Arg Gly Thr Lys Phe 

            20      





<210>  428

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  428



Ala His Ser Leu Glu Arg Val Cys His Cys Leu Gly Lys Trp Leu Gly 

1               5                   10                  15      





His Pro Asp Lys Phe 

            20      





<210>  429

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  429



Ala Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys 

1               5                   10                  15      





Gly Leu Ser Ala Thr 

            20      





<210>  430

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  430



Cys Gln Ser Ile Ala Phe Pro Ser Lys Thr Ser Ala Ser Ile Gly Ser 

1               5                   10                  15      





Leu Cys Ala Asp 

            20  





<210>  431

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  431



Ser Lys Thr Ser Ala Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met 

1               5                   10                  15      





Tyr Gly Val Leu 

            20  





<210>  432

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  432



Gly Val Leu Pro Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn 

1               5                   10                  15      





Leu Leu Ser Ile 

            20  





<210>  433

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  433



Phe Met Ile Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly 

1               5                   10                  15      





Arg Gly Thr Lys Phe 

            20      





<210>  434

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  434



Glu Leu Lys Val Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu 

1               5                   10                  15      





Val Leu Leu Ala Val 

            20      





<210>  435

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  435



Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys Ile Thr Leu 

1               5                   10                  15      





Phe Val Ile Val 

            20  





<210>  436

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  436



Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu Ile Ile Cys Tyr 

1               5                   10                  15      





Asn Trp Leu His Arg 

            20      





<210>  437

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  437



Val Ala Leu Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly 

1               5                   10                  15      





Gln Phe Leu Glu Glu 

            20      





<210>  438

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  438



Gly Phe Thr Cys Phe Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala 

1               5                   10                  15      





Met Glu Leu Lys Val 

            20      





<210>  439

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  439



Ile Thr Val Gly Leu Val Phe Leu Cys Leu Gln Tyr Arg Leu Arg Gly 

1               5                   10                  15      





Lys Leu Arg Ala Glu 

            20      





<210>  440

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  440



Val Ala Leu Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly 

1               5                   10                  15      





Gln Phe Leu Glu Glu 

            20      





<210>  441

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  441



Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn Leu 

1               5                   10                  15      





His Arg Thr Phe Asp 

            20      





<210>  442

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  442



Glu Leu Lys Val Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu 

1               5                   10                  15      





Val Leu Leu Ala Val 

            20      





<210>  443

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  443



Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn Leu 

1               5                   10                  15      





His Arg Thr Phe Asp 

            20      





<210>  444

<211>  14

<212>  PRT

<213>  Artificial sequence



<220>

<223>  BirA recognition motif



<400>  444



Leu Gly Gly Ile Phe Glu Ala Met Lys Met Glu Leu Arg Asp 

1               5                   10                  





<210>  445

<211>  25

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  445



Pro Glu Arg Tyr Gly Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu 

1               5                   10                  15      





Gly Lys Val Thr Leu Arg Ile Arg Asn 

            20                  25  





<210>  446

<211>  12

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  446



Thr Cys Phe Phe Arg Asp His Ser Tyr Gln Glu Glu 

1               5                   10          





<210>  447

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  447



Phe Val Ile Val Pro Val Leu Gly Pro 

1               5                   





<210>  448

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  448



Lys Ile Thr Leu Phe Val Ile Val Pro Val Leu Gly Pro 

1               5                   10              





<210>  449

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  449



Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys Gly Glu Pro 

1               5                   10              





<210>  450

<211>  18

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  450



Glu Pro Gly Ile Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys Gly Glu 

1               5                   10                  15      





Pro Gly 

        





<210>  451

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  451



Gly Val Val Ser His Ser Phe Pro Ala Thr Leu Glu Thr Gln Glu 

1               5                   10                  15  





<210>  452

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  452



Leu Ser Gly Leu Pro Ser Gly Gly Glu Val Leu Glu Ile Ser Val 

1               5                   10                  15  





<210>  453

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  453



Ile Ser Gly Leu Pro Ser Gly Gly Asp Asp Leu Glu Thr Ser Thr 

1               5                   10                  15  





<210>  454

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  454



Phe Phe Tyr Phe Phe Thr Gly Ser Ser Gln Leu Glu Phe Asp Pro 

1               5                   10                  15  





<210>  455

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  455



His Ala Tyr Ser Val Thr Gly Ala Glu Glu Val Glu Ser Asn Gly 

1               5                   10                  15  





<210>  456

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  456



Ser Ala Phe Trp Pro Ser Leu Pro Ser Gly Leu Asp Ala Ala Tyr 

1               5                   10                  15  





<210>  457

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  457



Cys Val Asp Thr Arg Ser Gly Asn Cys Tyr Leu Asp Ile Arg Pro 

1               5                   10                  15  





<210>  458

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  458



Val Lys Glu Gly His Ser Pro Pro Asp Asp Val Asp Ile Val Ile 

1               5                   10                  15  





<210>  459

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  459



Glu Pro Val Ser Gly Ser Phe Thr Thr Ala Leu Asp Gly Pro Ser 

1               5                   10                  15  





<210>  460

<211>  17

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  460



Arg Asp Tyr Phe Glu Glu Tyr Gly Lys Ile Asp Thr Ile Glu Ile Ile 

1               5                   10                  15      





Thr 

    





<210>  461

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  461



Leu Gly Gln Gln Gln Pro Phe Pro Pro Gln Gln Pro Tyr 

1               5                   10              





<210>  462

<211>  12

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  462



Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr 

1               5                   10          





<210>  463

<211>  14

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  463



Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro Gln Leu Pro Tyr 

1               5                   10                  





<210>  464

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  464



Pro Gly Gln Gln Gln Pro Phe Pro Pro Gln Gln Pro Tyr 

1               5                   10              





<210>  465

<211>  11

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  465



Gly Ile Ile Gln Pro Gln Gln Pro Ala Gln Leu 

1               5                   10      





<210>  466

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  466



Phe Pro Gln Gln Pro Gln Gln Pro Tyr Pro Gln Gln Pro 

1               5                   10              





<210>  467

<211>  12

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  467



Phe Ser Gln Pro Gln Gln Gln Phe Pro Gln Pro Gln 

1               5                   10          





<210>  468

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  468



Pro Gln Gln Pro Phe Pro Gln Gln Pro Gln Gln Pro Tyr 

1               5                   10              





<210>  469

<211>  26

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  469



Phe Leu Gln Pro Gln Gln Pro Phe Pro Gln Gln Pro Gln Gln Pro Tyr 

1               5                   10                  15      





Pro Gln Gln Pro Gln Gln Pro Phe Pro Gln 

            20                  25      





<210>  470

<211>  11

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  470



Ala Leu Pro Thr Ala Gln Val Pro Thr Asp Pro 

1               5                   10      





<210>  471

<211>  11

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  471



Gly Arg Leu Phe Asp Gln Arg Phe Gly Glu Gly 

1               5                   10      





<210>  472

<211>  21

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Autoantigenic peptide



<400>  472



Met Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu 

1               5                   10                  15      





Tyr Arg Asn Gly Lys 

            20      





<210>  473

<211>  11

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Amino acid sequence encoding Gliadin-61-71



<400>  473



Phe Pro Gln Pro Glu Leu Pro Tyr Pro Gln Pro 

1               5                   10      





<210>  474

<211>  22

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Amino acid sequence encoding Gliadin-3-24



<400>  474



Val Pro Val Pro Gln Leu Gln Pro Gln Asn Pro Ser Gln Gln Gln Pro 

1               5                   10                  15      





Gln Glu Gln Val Pro Leu 

            20          





