                         SEQUENCE LISTING

<110>  UCL Business PLC
 
<120>  NUCLEIC ACID CONSTRUCT

<130>  P106293PCT

<150>  GB1507119.4
<151>  2015-04-27

<160>  255   

<170>  PatentIn version 3.5

<210>  1
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tyrosinase-related protein (TYRP)-1 intracellular retention 
       signal

<400>  1

Asn Gln Pro Leu Leu Thr Asp 
1               5           


<210>  2
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Adenoviral E3/19K intracellular retention signal

<400>  2

Lys Tyr Lys Ser Arg Arg Ser Phe Ile Asp Glu Lys Lys Met Pro 
1               5                   10                  15  


<210>  3
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Adenoviral E3/19K intracellular retention signal

<400>  3

Asp Glu Lys Lys Met Pro 
1               5       


<210>  4
<211>  1114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR AND NOT gate which recognizes CD19 AND NOT CD33 based on 
       PTPN6 phosphatase

<400>  4

Met Ser Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Lys Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly 
145                 150                 155                 160 


Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly 
                165                 170                 175     


Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg 
            180                 185                 190         


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr 
        195                 200                 205             


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser 
    210                 215                 220                 


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
225                 230                 235                 240 


Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
                245                 250                 255     


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Asp Pro 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Phe Trp 
305                 310                 315                 320 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
                325                 330                 335     


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Arg Val Lys Phe Ser Arg 
            340                 345                 350         


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
        355                 360                 365             


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
    370                 375                 380                 


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
385                 390                 395                 400 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
                405                 410                 415     


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
            420                 425                 430         


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
        435                 440                 445             


Ala Leu His Met Gln Ala Leu Pro Pro Arg Arg Ala Glu Gly Arg Gly 
    450                 455                 460                 


Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala 
465                 470                 475                 480 


Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr Asp Ala 
                485                 490                 495     


Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
            500                 505                 510         


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Tyr 
        515                 520                 525             


Phe Asn Leu Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
    530                 535                 540                 


Leu Ile Tyr Asp Thr Asn Arg Leu Ala Asp Gly Val Pro Ser Arg Phe 
545                 550                 555                 560 


Ser Gly Ser Gly Ser Gly Thr Gln Tyr Thr Leu Thr Ile Ser Ser Leu 
                565                 570                 575     


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr Lys Asn Tyr 
            580                 585                 590         


Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Ser Gly 
        595                 600                 605             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Arg Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
625                 630                 635                 640 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                645                 650                 655     


Thr Leu Ser Asn Tyr Gly Met His Trp Ile Arg Gln Ala Pro Gly Lys 
            660                 665                 670         


Gly Leu Glu Trp Val Ser Ser Ile Ser Leu Asn Gly Gly Ser Thr Tyr 
        675                 680                 685             


Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
    690                 695                 700                 


Lys Ser Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
705                 710                 715                 720 


Ala Val Tyr Tyr Cys Ala Ala Gln Asp Ala Tyr Thr Gly Gly Tyr Phe 
                725                 730                 735     


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Met Asp Pro 
            740                 745                 750         


Ala Thr Thr Thr Lys Pro Val Leu Arg Thr Pro Ser Pro Val His Pro 
        755                 760                 765             


Thr Gly Thr Ser Gln Pro Gln Arg Pro Glu Asp Cys Arg Pro Arg Gly 
    770                 775                 780                 


Ser Val Lys Gly Thr Gly Leu Asp Phe Ala Cys Asp Ile Tyr Trp Ala 
785                 790                 795                 800 


Pro Leu Ala Gly Ile Cys Val Ala Leu Leu Leu Ser Leu Ile Ile Thr 
                805                 810                 815     


Leu Ile Cys Tyr His Arg Ser Arg Lys Arg Val Cys Lys Ser Gly Gly 
            820                 825                 830         


Gly Ser Phe Trp Glu Glu Phe Glu Ser Leu Gln Lys Gln Glu Val Lys 
        835                 840                 845             


Asn Leu His Gln Arg Leu Glu Gly Gln Arg Pro Glu Asn Lys Gly Lys 
    850                 855                 860                 


Asn Arg Tyr Lys Asn Ile Leu Pro Phe Asp His Ser Arg Val Ile Leu 
865                 870                 875                 880 


Gln Gly Arg Asp Ser Asn Ile Pro Gly Ser Asp Tyr Ile Asn Ala Asn 
                885                 890                 895     


Tyr Ile Lys Asn Gln Leu Leu Gly Pro Asp Glu Asn Ala Lys Thr Tyr 
            900                 905                 910         


Ile Ala Ser Gln Gly Cys Leu Glu Ala Thr Val Asn Asp Phe Trp Gln 
        915                 920                 925             


Met Ala Trp Gln Glu Asn Ser Arg Val Ile Val Met Thr Thr Arg Glu 
    930                 935                 940                 


Val Glu Lys Gly Arg Asn Lys Cys Val Pro Tyr Trp Pro Glu Val Gly 
945                 950                 955                 960 


Met Gln Arg Ala Tyr Gly Pro Tyr Ser Val Thr Asn Cys Gly Glu His 
                965                 970                 975     


Asp Thr Thr Glu Tyr Lys Leu Arg Thr Leu Gln Val Ser Pro Leu Asp 
            980                 985                 990         


Asn Gly Asp Leu Ile Arg Glu Ile  Trp His Tyr Gln Tyr  Leu Ser Trp 
        995                 1000                 1005             


Pro Asp  His Gly Val Pro Ser  Glu Pro Gly Gly Val  Leu Ser Phe 
    1010                 1015                 1020             


Leu Asp  Gln Ile Asn Gln Arg  Gln Glu Ser Leu Pro  His Ala Gly 
    1025                 1030                 1035             


Pro Ile  Ile Val His Cys Ser  Ala Gly Ile Gly Arg  Thr Gly Thr 
    1040                 1045                 1050             


Ile Ile  Val Ile Asp Met Leu  Met Glu Asn Ile Ser  Thr Lys Gly 
    1055                 1060                 1065             


Leu Asp  Cys Asp Ile Asp Ile  Gln Lys Thr Ile Gln  Met Val Arg 
    1070                 1075                 1080             


Ala Gln  Arg Ser Gly Met Val  Gln Thr Glu Ala Gln  Tyr Lys Phe 
    1085                 1090                 1095             


Ile Tyr  Val Ala Ile Ala Gln  Phe Ile Glu Thr Thr  Lys Lys Lys 
    1100                 1105                 1110             


Leu 
    


<210>  5
<211>  918
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR AND NOT gate which recognizes CD19 AND NOT CD33 and is based 
       on an ITIM containing endodomain from LAIR1

<400>  5

Met Ser Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Lys Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly 
145                 150                 155                 160 


Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly 
                165                 170                 175     


Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg 
            180                 185                 190         


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr 
        195                 200                 205             


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser 
    210                 215                 220                 


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
225                 230                 235                 240 


Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
                245                 250                 255     


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Asp Pro 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Phe Trp 
305                 310                 315                 320 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
                325                 330                 335     


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Arg Val Lys Phe Ser Arg 
            340                 345                 350         


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
        355                 360                 365             


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
    370                 375                 380                 


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
385                 390                 395                 400 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
                405                 410                 415     


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
            420                 425                 430         


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
        435                 440                 445             


Ala Leu His Met Gln Ala Leu Pro Pro Arg Arg Ala Glu Gly Arg Gly 
    450                 455                 460                 


Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala 
465                 470                 475                 480 


Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr Asp Ala 
                485                 490                 495     


Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
            500                 505                 510         


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Tyr 
        515                 520                 525             


Phe Asn Leu Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
    530                 535                 540                 


Leu Ile Tyr Asp Thr Asn Arg Leu Ala Asp Gly Val Pro Ser Arg Phe 
545                 550                 555                 560 


Ser Gly Ser Gly Ser Gly Thr Gln Tyr Thr Leu Thr Ile Ser Ser Leu 
                565                 570                 575     


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr Lys Asn Tyr 
            580                 585                 590         


Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Ser Gly 
        595                 600                 605             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Arg Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
625                 630                 635                 640 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                645                 650                 655     


Thr Leu Ser Asn Tyr Gly Met His Trp Ile Arg Gln Ala Pro Gly Lys 
            660                 665                 670         


Gly Leu Glu Trp Val Ser Ser Ile Ser Leu Asn Gly Gly Ser Thr Tyr 
        675                 680                 685             


Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
    690                 695                 700                 


Lys Ser Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
705                 710                 715                 720 


Ala Val Tyr Tyr Cys Ala Ala Gln Asp Ala Tyr Thr Gly Gly Tyr Phe 
                725                 730                 735     


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Met Asp Pro 
            740                 745                 750         


Ala Thr Thr Thr Lys Pro Val Leu Arg Thr Pro Ser Pro Val His Pro 
        755                 760                 765             


Thr Gly Thr Ser Gln Pro Gln Arg Pro Glu Asp Cys Arg Pro Arg Gly 
    770                 775                 780                 


Ser Val Lys Gly Thr Gly Leu Asp Phe Ala Cys Asp Ile Leu Ile Gly 
785                 790                 795                 800 


Val Ser Val Val Phe Leu Phe Cys Leu Leu Leu Leu Val Leu Phe Cys 
                805                 810                 815     


Leu His Arg Gln Asn Gln Ile Lys Gln Gly Pro Pro Arg Ser Lys Asp 
            820                 825                 830         


Glu Glu Gln Lys Pro Gln Gln Arg Pro Asp Leu Ala Val Asp Val Leu 
        835                 840                 845             


Glu Arg Thr Ala Asp Lys Ala Thr Val Asn Gly Leu Pro Glu Lys Asp 
    850                 855                 860                 


Arg Glu Thr Asp Thr Ser Ala Leu Ala Ala Gly Ser Ser Gln Glu Val 
865                 870                 875                 880 


Thr Tyr Ala Gln Leu Asp His Trp Ala Leu Thr Gln Arg Thr Ala Arg 
                885                 890                 895     


Ala Val Ser Pro Gln Ser Thr Lys Pro Met Ala Glu Ser Ile Thr Tyr 
            900                 905                 910         


Ala Ala Val Ala Arg His 
        915             


<210>  6
<211>  1363
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR AND NOT gate which recognizes CD19 AND NOT CD33 and recruits 
       a PTPN6-CD148 fusion protein to an ITIM containing endodomain

<400>  6

Met Ser Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Lys Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly 
145                 150                 155                 160 


Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly 
                165                 170                 175     


Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg 
            180                 185                 190         


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr 
        195                 200                 205             


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser 
    210                 215                 220                 


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
225                 230                 235                 240 


Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
                245                 250                 255     


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Asp Pro 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Phe Trp 
305                 310                 315                 320 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
                325                 330                 335     


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Arg Val Lys Phe Ser Arg 
            340                 345                 350         


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
        355                 360                 365             


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
    370                 375                 380                 


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
385                 390                 395                 400 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
                405                 410                 415     


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
            420                 425                 430         


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
        435                 440                 445             


Ala Leu His Met Gln Ala Leu Pro Pro Arg Arg Ala Glu Gly Arg Gly 
    450                 455                 460                 


Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala 
465                 470                 475                 480 


Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr Asp Ala 
                485                 490                 495     


Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
            500                 505                 510         


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Tyr 
        515                 520                 525             


Phe Asn Leu Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
    530                 535                 540                 


Leu Ile Tyr Asp Thr Asn Arg Leu Ala Asp Gly Val Pro Ser Arg Phe 
545                 550                 555                 560 


Ser Gly Ser Gly Ser Gly Thr Gln Tyr Thr Leu Thr Ile Ser Ser Leu 
                565                 570                 575     


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr Lys Asn Tyr 
            580                 585                 590         


Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Ser Gly 
        595                 600                 605             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Arg Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
625                 630                 635                 640 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                645                 650                 655     


Thr Leu Ser Asn Tyr Gly Met His Trp Ile Arg Gln Ala Pro Gly Lys 
            660                 665                 670         


Gly Leu Glu Trp Val Ser Ser Ile Ser Leu Asn Gly Gly Ser Thr Tyr 
        675                 680                 685             


Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
    690                 695                 700                 


Lys Ser Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
705                 710                 715                 720 


Ala Val Tyr Tyr Cys Ala Ala Gln Asp Ala Tyr Thr Gly Gly Tyr Phe 
                725                 730                 735     


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Met Asp Pro 
            740                 745                 750         


Ala Thr Thr Thr Lys Pro Val Leu Arg Thr Pro Ser Pro Val His Pro 
        755                 760                 765             


Thr Gly Thr Ser Gln Pro Gln Arg Pro Glu Asp Cys Arg Pro Arg Gly 
    770                 775                 780                 


Ser Val Lys Gly Thr Gly Leu Asp Phe Ala Cys Asp Ile Leu Ile Gly 
785                 790                 795                 800 


Val Ser Val Val Phe Leu Phe Cys Leu Leu Leu Leu Val Leu Phe Cys 
                805                 810                 815     


Leu His Arg Gln Asn Gln Ile Lys Gln Gly Pro Pro Arg Ser Lys Asp 
            820                 825                 830         


Glu Glu Gln Lys Pro Gln Gln Arg Pro Asp Leu Ala Val Asp Val Leu 
        835                 840                 845             


Glu Arg Thr Ala Asp Lys Ala Thr Val Asn Gly Leu Pro Glu Lys Asp 
    850                 855                 860                 


Arg Glu Thr Asp Thr Ser Ala Leu Ala Ala Gly Ser Ser Gln Glu Val 
865                 870                 875                 880 


Thr Tyr Ala Gln Leu Asp His Trp Ala Leu Thr Gln Arg Thr Ala Arg 
                885                 890                 895     


Ala Val Ser Pro Gln Ser Thr Lys Pro Met Ala Glu Ser Ile Thr Tyr 
            900                 905                 910         


Ala Ala Val Ala Arg His Arg Ala Glu Gly Arg Gly Ser Leu Leu Thr 
        915                 920                 925             


Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Trp Tyr His Gly His Met 
    930                 935                 940                 


Ser Gly Gly Gln Ala Glu Thr Leu Leu Gln Ala Lys Gly Glu Pro Trp 
945                 950                 955                 960 


Thr Phe Leu Val Arg Glu Ser Leu Ser Gln Pro Gly Asp Phe Val Leu 
                965                 970                 975     


Ser Val Leu Ser Asp Gln Pro Lys Ala Gly Pro Gly Ser Pro Leu Arg 
            980                 985                 990         


Val Thr His Ile Lys Val Met Cys  Glu Gly Gly Arg Tyr  Thr Val Gly 
        995                 1000                 1005             


Gly Leu  Glu Thr Phe Asp Ser  Leu Thr Asp Leu Val  Glu His Phe 
    1010                 1015                 1020             


Lys Lys  Thr Gly Ile Glu Glu  Ala Ser Gly Ala Phe  Val Tyr Leu 
    1025                 1030                 1035             


Arg Gln  Pro Tyr Ser Gly Gly  Gly Gly Ser Phe Glu  Ala Tyr Phe 
    1040                 1045                 1050             


Lys Lys  Gln Gln Ala Asp Ser  Asn Cys Gly Phe Ala  Glu Glu Tyr 
    1055                 1060                 1065             


Glu Asp  Leu Lys Leu Val Gly  Ile Ser Gln Pro Lys  Tyr Ala Ala 
    1070                 1075                 1080             


Glu Leu  Ala Glu Asn Arg Gly  Lys Asn Arg Tyr Asn  Asn Val Leu 
    1085                 1090                 1095             


Pro Tyr  Asp Ile Ser Arg Val  Lys Leu Ser Val Gln  Thr His Ser 
    1100                 1105                 1110             


Thr Asp  Asp Tyr Ile Asn Ala  Asn Tyr Met Pro Gly  Tyr His Ser 
    1115                 1120                 1125             


Lys Lys  Asp Phe Ile Ala Thr  Gln Gly Pro Leu Pro  Asn Thr Leu 
    1130                 1135                 1140             


Lys Asp  Phe Trp Arg Met Val  Trp Glu Lys Asn Val  Tyr Ala Ile 
    1145                 1150                 1155             


Ile Met  Leu Thr Lys Cys Val  Glu Gln Gly Arg Thr  Lys Cys Glu 
    1160                 1165                 1170             


Glu Tyr  Trp Pro Ser Lys Gln  Ala Gln Asp Tyr Gly  Asp Ile Thr 
    1175                 1180                 1185             


Val Ala  Met Thr Ser Glu Ile  Val Leu Pro Glu Trp  Thr Ile Arg 
    1190                 1195                 1200             


Asp Phe  Thr Val Lys Asn Ile  Gln Thr Ser Glu Ser  His Pro Leu 
    1205                 1210                 1215             


Arg Gln  Phe His Phe Thr Ser  Trp Pro Asp His Gly  Val Pro Asp 
    1220                 1225                 1230             


Thr Thr  Asp Leu Leu Ile Asn  Phe Arg Tyr Leu Val  Arg Asp Tyr 
    1235                 1240                 1245             


Met Lys  Gln Ser Pro Pro Glu  Ser Pro Ile Leu Val  His Cys Ser 
    1250                 1255                 1260             


Ala Gly  Val Gly Arg Thr Gly  Thr Phe Ile Ala Ile  Asp Arg Leu 
    1265                 1270                 1275             


Ile Tyr  Gln Ile Glu Asn Glu  Asn Thr Val Asp Val  Tyr Gly Ile 
    1280                 1285                 1290             


Val Tyr  Asp Leu Arg Met His  Arg Pro Leu Met Val  Gln Thr Glu 
    1295                 1300                 1305             


Asp Gln  Tyr Val Phe Leu Asn  Gln Cys Val Leu Asp  Ile Val Arg 
    1310                 1315                 1320             


Ser Gln  Lys Asp Ser Lys Val  Asp Leu Ile Tyr Gln  Asn Thr Thr 
    1325                 1330                 1335             


Ala Met  Thr Ile Tyr Glu Asn  Leu Ala Pro Val Thr  Thr Phe Gly 
    1340                 1345                 1350             


Lys Thr  Asn Gly Tyr Ile Ala  Ser Gly Ser 
    1355                 1360             


<210>  7
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nucleic acid construct comprising a tyrp-1 retention protein 
       sequence

<400>  7

Arg Ala Arg Arg Ser Met Asp Glu Ala Asn Gln Pro Leu Leu Thr Asp 
1               5                   10                  15      


Gln Tyr Gln Cys Tyr Ala Glu Glu Tyr Glu Lys Leu Gln Asn Pro Asn 
            20                  25                  30          


Gln Ser Val Val 
        35      


<210>  8
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spacer sequence, hinge-CH2CH3 of human IgG1

<400>  8

Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp 
225                 230                 


<210>  9
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spacer sequence, human CD8 stalk

<400>  9

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        35                  40                  45      


<210>  10
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spacer sequence, human IgG1 hinge

<400>  10

Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Lys Asp Pro Lys 
            20  


<210>  11
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spacer sequence, CD2 ectodomain

<400>  11

Lys Glu Ile Thr Asn Ala Leu Glu Thr Trp Gly Ala Leu Gly Gln Asp 
1               5                   10                  15      


Ile Asn Leu Asp Ile Pro Ser Phe Gln Met Ser Asp Asp Ile Asp Asp 
            20                  25                  30          


Ile Lys Trp Glu Lys Thr Ser Asp Lys Lys Lys Ile Ala Gln Phe Arg 
        35                  40                  45              


Lys Glu Lys Glu Thr Phe Lys Glu Lys Asp Thr Tyr Lys Leu Phe Lys 
    50                  55                  60                  


Asn Gly Thr Leu Lys Ile Lys His Leu Lys Thr Asp Asp Gln Asp Ile 
65                  70                  75                  80  


Tyr Lys Val Ser Ile Tyr Asp Thr Lys Gly Lys Asn Val Leu Glu Lys 
                85                  90                  95      


Ile Phe Asp Leu Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser 
            100                 105                 110         


Trp Thr Cys Ile Asn Thr Thr Leu Thr Cys Glu Val Met Asn Gly Thr 
        115                 120                 125             


Asp Pro Glu Leu Asn Leu Tyr Gln Asp Gly Lys His Leu Lys Leu Ser 
    130                 135                 140                 


Gln Arg Val Ile Thr His Lys Trp Thr Thr Ser Leu Ser Ala Lys Phe 
145                 150                 155                 160 


Lys Cys Thr Ala Gly Asn Lys Val Ser Lys Glu Ser Ser Val Glu Pro 
                165                 170                 175     


Val Ser Cys Pro Glu Lys Gly Leu Asp 
            180                 185 


<210>  12
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spacer sequence, CD34 ectodomain

<400>  12

Ser Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro Thr Gln Gly 
1               5                   10                  15      


Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu Thr Thr Thr 
            20                  25                  30          


Pro Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser Gln His Gly 
        35                  40                  45              


Asn Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys Phe Thr Ser 
    50                  55                  60                  


Thr Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser Ser Val Gln 
65                  70                  75                  80  


Ser Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro Ala Asn Val 
                85                  90                  95      


Ser Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro Gly Asn Val 
            100                 105                 110         


Ser Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser Pro Thr Lys 
        115                 120                 125             


Pro Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys Ala Glu Ile 
    130                 135                 140                 


Lys Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly Ile Cys Leu 
145                 150                 155                 160 


Glu Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys Asp Arg Gly 
                165                 170                 175     


Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala Asp Ala Asp 
            180                 185                 190         


Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser Glu Val Arg 
        195                 200                 205             


Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu Ile Ser Ser 
    210                 215                 220                 


Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys Lys Leu Gly 
225                 230                 235                 240 


Ile Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln Ser Tyr Ser 
                245                 250                 255     


Gln Lys Thr 
            


<210>  13
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  comprising CD28 transmembrane domain and CD3 Z endodomain

<400>  13

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Arg Val Lys Phe 
            20                  25                  30          


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
        35                  40                  45              


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
    50                  55                  60                  


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
65                  70                  75                  80  


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
                85                  90                  95      


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
            100                 105                 110         


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
        115                 120                 125             


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    130                 135                 140 


<210>  14
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  comprising CD28 transmembrane domain and CD28 and CD3 Zeta 
       endodomains

<400>  14

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
65                  70                  75                  80  


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
                85                  90                  95      


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
            100                 105                 110         


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
        115                 120                 125             


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
    130                 135                 140                 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
145                 150                 155                 160 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
                165                 170                 175     


Leu Pro Pro Arg 
            180 


<210>  15
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  comprising CD28 transmembrane domain and CD28, OX40 and CD3 Zeta 
       endodomains

<400>  15

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro 
65                  70                  75                  80  


Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp 
                85                  90                  95      


Ala His Ser Thr Leu Ala Lys Ile Arg Val Lys Phe Ser Arg Ser Ala 
            100                 105                 110         


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
        115                 120                 125             


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
    130                 135                 140                 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
145                 150                 155                 160 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
                165                 170                 175     


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
            180                 185                 190         


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
        195                 200                 205             


His Met Gln Ala Leu Pro Pro Arg 
    210                 215     


<210>  16
<211>  595
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of PTPN6

<400>  16

Met Val Arg Trp Phe His Arg Asp Leu Ser Gly Leu Asp Ala Glu Thr 
1               5                   10                  15      


Leu Leu Lys Gly Arg Gly Val His Gly Ser Phe Leu Ala Arg Pro Ser 
            20                  25                  30          


Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Val Arg Val Gly Asp Gln 
        35                  40                  45              


Val Thr His Ile Arg Ile Gln Asn Ser Gly Asp Phe Tyr Asp Leu Tyr 
    50                  55                  60                  


Gly Gly Glu Lys Phe Ala Thr Leu Thr Glu Leu Val Glu Tyr Tyr Thr 
65                  70                  75                  80  


Gln Gln Gln Gly Val Leu Gln Asp Arg Asp Gly Thr Ile Ile His Leu 
                85                  90                  95      


Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Ser Glu Arg Trp Tyr His 
            100                 105                 110         


Gly His Met Ser Gly Gly Gln Ala Glu Thr Leu Leu Gln Ala Lys Gly 
        115                 120                 125             


Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Leu Ser Gln Pro Gly Asp 
    130                 135                 140                 


Phe Val Leu Ser Val Leu Ser Asp Gln Pro Lys Ala Gly Pro Gly Ser 
145                 150                 155                 160 


Pro Leu Arg Val Thr His Ile Lys Val Met Cys Glu Gly Gly Arg Tyr 
                165                 170                 175     


Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Leu Thr Asp Leu Val Glu 
            180                 185                 190         


His Phe Lys Lys Thr Gly Ile Glu Glu Ala Ser Gly Ala Phe Val Tyr 
        195                 200                 205             


Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val Asn Ala Ala Asp Ile Glu 
    210                 215                 220                 


Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Glu Ser Glu Asp Thr Ala 
225                 230                 235                 240 


Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Leu Gln Lys Gln Glu Val 
                245                 250                 255     


Lys Asn Leu His Gln Arg Leu Glu Gly Gln Arg Pro Glu Asn Lys Gly 
            260                 265                 270         


Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe Asp His Ser Arg Val Ile 
        275                 280                 285             


Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Ser Asp Tyr Ile Asn Ala 
    290                 295                 300                 


Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro Asp Glu Asn Ala Lys Thr 
305                 310                 315                 320 


Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Thr Val Asn Asp Phe Trp 
                325                 330                 335     


Gln Met Ala Trp Gln Glu Asn Ser Arg Val Ile Val Met Thr Thr Arg 
            340                 345                 350         


Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pro Tyr Trp Pro Glu Val 
        355                 360                 365             


Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Val Thr Asn Cys Gly Glu 
    370                 375                 380                 


His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Leu Gln Val Ser Pro Leu 
385                 390                 395                 400 


Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp His Tyr Gln Tyr Leu Ser 
                405                 410                 415     


Trp Pro Asp His Gly Val Pro Ser Glu Pro Gly Gly Val Leu Ser Phe 
            420                 425                 430         


Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Leu Pro His Ala Gly Pro 
        435                 440                 445             


Ile Ile Val His Cys Ser Ala Gly Ile Gly Arg Thr Gly Thr Ile Ile 
    450                 455                 460                 


Val Ile Asp Met Leu Met Glu Asn Ile Ser Thr Lys Gly Leu Asp Cys 
465                 470                 475                 480 


Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Val Arg Ala Gln Arg Ser 
                485                 490                 495     


Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Phe Ile Tyr Val Ala Ile 
            500                 505                 510         


Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Leu Glu Val Leu Gln Ser 
        515                 520                 525             


Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Ile Thr Tyr Pro Pro Ala 
    530                 535                 540                 


Met Lys Asn Ala His Ala Lys Ala Ser Arg Thr Ser Ser Lys His Lys 
545                 550                 555                 560 


Glu Asp Val Tyr Glu Asn Leu His Thr Lys Asn Lys Arg Glu Glu Lys 
                565                 570                 575     


Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Lys Ser Lys Gly Ser Leu 
            580                 585                 590         


Lys Arg Lys 
        595 


<210>  17
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of phosphatase domain of PTPN6

<400>  17

Phe Trp Glu Glu Phe Glu Ser Leu Gln Lys Gln Glu Val Lys Asn Leu 
1               5                   10                  15      


His Gln Arg Leu Glu Gly Gln Arg Pro Glu Asn Lys Gly Lys Asn Arg 
            20                  25                  30          


Tyr Lys Asn Ile Leu Pro Phe Asp His Ser Arg Val Ile Leu Gln Gly 
        35                  40                  45              


Arg Asp Ser Asn Ile Pro Gly Ser Asp Tyr Ile Asn Ala Asn Tyr Ile 
    50                  55                  60                  


Lys Asn Gln Leu Leu Gly Pro Asp Glu Asn Ala Lys Thr Tyr Ile Ala 
65                  70                  75                  80  


Ser Gln Gly Cys Leu Glu Ala Thr Val Asn Asp Phe Trp Gln Met Ala 
                85                  90                  95      


Trp Gln Glu Asn Ser Arg Val Ile Val Met Thr Thr Arg Glu Val Glu 
            100                 105                 110         


Lys Gly Arg Asn Lys Cys Val Pro Tyr Trp Pro Glu Val Gly Met Gln 
        115                 120                 125             


Arg Ala Tyr Gly Pro Tyr Ser Val Thr Asn Cys Gly Glu His Asp Thr 
    130                 135                 140                 


Thr Glu Tyr Lys Leu Arg Thr Leu Gln Val Ser Pro Leu Asp Asn Gly 
145                 150                 155                 160 


Asp Leu Ile Arg Glu Ile Trp His Tyr Gln Tyr Leu Ser Trp Pro Asp 
                165                 170                 175     


His Gly Val Pro Ser Glu Pro Gly Gly Val Leu Ser Phe Leu Asp Gln 
            180                 185                 190         


Ile Asn Gln Arg Gln Glu Ser Leu Pro His Ala Gly Pro Ile Ile Val 
        195                 200                 205             


His Cys Ser Ala Gly Ile Gly Arg Thr Gly Thr Ile Ile Val Ile Asp 
    210                 215                 220                 


Met Leu Met Glu Asn Ile Ser Thr Lys Gly Leu Asp Cys Asp Ile Asp 
225                 230                 235                 240 


Ile Gln Lys Thr Ile Gln Met Val Arg Ala Gln Arg Ser Gly Met Val 
                245                 250                 255     


Gln Thr Glu Ala Gln Tyr Lys Phe Ile Tyr Val Ala Ile Ala Gln Phe 
            260                 265                 270         


<210>  18
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDCD1 endodomain

<400>  18

Cys Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln 
1               5                   10                  15      


Pro Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr 
            20                  25                  30          


Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val 
        35                  40                  45              


Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser 
    50                  55                  60                  


Gly Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro 
65                  70                  75                  80  


Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro 
                85                  90                  95      


Leu 
    


<210>  19
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BTLA4 endodomain

<400>  19

Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly Leu Gln 
1               5                   10                  15      


Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys Val Arg 
            20                  25                  30          


Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr Asn Pro 
        35                  40                  45              


Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro Glu Met 
    50                  55                  60                  


Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln Arg Pro 
65                  70                  75                  80  


Pro Pro Asp Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His Lys Arg 
                85                  90                  95      


Gln Val Gly Asp Tyr Glu Asn Val Ile Pro Asp Phe Pro Glu Asp Glu 
            100                 105                 110         


Gly Ile His Tyr Ser Glu Leu Ile Gln Phe Gly Val Gly Glu Arg Pro 
        115                 120                 125             


Gln Ala Gln Glu Asn Val Asp Tyr Val Ile Leu Lys His 
    130                 135                 140     


<210>  20
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LILRB1 endodomain

<400>  20

Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln Arg Lys 
1               5                   10                  15      


Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro Thr Asp 
            20                  25                  30          


Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln Glu Glu 
        35                  40                  45              


Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly Val Glu 
    50                  55                  60                  


Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr 
65                  70                  75                  80  


Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser Pro Pro 
                85                  90                  95      


Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Ala Glu 
            100                 105                 110         


Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Pro Gln 
        115                 120                 125             


Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala 
    130                 135                 140                 


Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser 
145                 150                 155                 160 


Ile Tyr Ala Thr Leu Ala Ile His 
                165             


<210>  21
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAIR1 endodomain

<400>  21

His Arg Gln Asn Gln Ile Lys Gln Gly Pro Pro Arg Ser Lys Asp Glu 
1               5                   10                  15      


Glu Gln Lys Pro Gln Gln Arg Pro Asp Leu Ala Val Asp Val Leu Glu 
            20                  25                  30          


Arg Thr Ala Asp Lys Ala Thr Val Asn Gly Leu Pro Glu Lys Asp Arg 
        35                  40                  45              


Glu Thr Asp Thr Ser Ala Leu Ala Ala Gly Ser Ser Gln Glu Val Thr 
    50                  55                  60                  


Tyr Ala Gln Leu Asp His Trp Ala Leu Thr Gln Arg Thr Ala Arg Ala 
65                  70                  75                  80  


Val Ser Pro Gln Ser Thr Lys Pro Met Ala Glu Ser Ile Thr Tyr Ala 
                85                  90                  95      


Ala Val Ala Arg His 
            100     


<210>  22
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTLA4 endodomain

<400>  22

Phe Leu Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe Tyr 
1               5                   10                  15      


Ser Phe Leu Leu Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys Arg 
            20                  25                  30          


Ser Pro Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu Pro 
        35                  40                  45              


Glu Cys Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
    50                  55                  60          


<210>  23
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIR2DL1 endodomain

<400>  23

Gly Asn Ser Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Ile 
1               5                   10                  15      


Ile Pro Phe Ala Ile Leu Leu Phe Phe Leu Leu His Arg Trp Cys Ala 
            20                  25                  30          


Asn Lys Lys Asn Ala Val Val Met Asp Gln Glu Pro Ala Gly Asn Arg 
        35                  40                  45              


Thr Val Asn Arg Glu Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr 
    50                  55                  60                  


Tyr Thr Gln Leu Asn His Cys Val Phe Thr Gln Arg Lys Ile Thr Arg 
65                  70                  75                  80  


Pro Ser Gln Arg Pro Lys Thr Pro Pro Thr Asp Ile Ile Val Tyr Thr 
                85                  90                  95      


Glu Leu Pro Asn Ala Glu Ser Arg Ser Lys Val Val Ser Cys Pro 
            100                 105                 110     


<210>  24
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIR2DL4 endodomain

<400>  24

Gly Ile Ala Arg His Leu His Ala Val Ile Arg Tyr Ser Val Ala Ile 
1               5                   10                  15      


Ile Leu Phe Thr Ile Leu Pro Phe Phe Leu Leu His Arg Trp Cys Ser 
            20                  25                  30          


Lys Lys Lys Glu Asn Ala Ala Val Met Asn Gln Glu Pro Ala Gly His 
        35                  40                  45              


Arg Thr Val Asn Arg Glu Asp Ser Asp Glu Gln Asp Pro Gln Glu Val 
    50                  55                  60                  


Thr Tyr Ala Gln Leu Asp His Cys Ile Phe Thr Gln Arg Lys Ile Thr 
65                  70                  75                  80  


Gly Pro Ser Gln Arg Ser Lys Arg Pro Ser Thr Asp Thr Ser Val Cys 
                85                  90                  95      


Ile Glu Leu Pro Asn Ala Glu Pro Arg Ala Leu Ser Pro Ala His Glu 
            100                 105                 110         


His His Ser Gln Ala Leu Met Gly Ser Ser Arg Glu Thr Thr Ala Leu 
        115                 120                 125             


Ser Gln Thr Gln Leu Ala Ser Ser Asn Val Pro Ala Ala Gly Ile 
    130                 135                 140             


<210>  25
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIR2DL5 endodomain

<400>  25

Thr Gly Ile Arg Arg His Leu His Ile Leu Ile Gly Thr Ser Val Ala 
1               5                   10                  15      


Ile Ile Leu Phe Ile Ile Leu Phe Phe Phe Leu Leu His Cys Cys Cys 
            20                  25                  30          


Ser Asn Lys Lys Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asp 
        35                  40                  45              


Arg Thr Val Asn Arg Glu Asp Ser Asp Asp Gln Asp Pro Gln Glu Val 
    50                  55                  60                  


Thr Tyr Ala Gln Leu Asp His Cys Val Phe Thr Gln Thr Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Ser Gln Arg Pro Lys Thr Pro Pro Thr Asp Thr Thr Met Tyr 
                85                  90                  95      


Met Glu Leu Pro Asn Ala Lys Pro Arg Ser Leu Ser Pro Ala His Lys 
            100                 105                 110         


His His Ser Gln Ala Leu Arg Gly Ser Ser Arg Glu Thr Thr Ala Leu 
        115                 120                 125             


Ser Gln Asn Arg Val Ala Ser Ser His Val Pro Ala Ala Gly Ile 
    130                 135                 140             


<210>  26
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIR3DL1 endodomain

<400>  26

Lys Asp Pro Arg His Leu His Ile Leu Ile Gly Thr Ser Val Val Ile 
1               5                   10                  15      


Ile Leu Phe Ile Leu Leu Leu Phe Phe Leu Leu His Leu Trp Cys Ser 
            20                  25                  30          


Asn Lys Lys Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asn Arg 
        35                  40                  45              


Thr Ala Asn Ser Glu Asp Ser Asp Glu Gln Asp Pro Glu Glu Val Thr 
    50                  55                  60                  


Tyr Ala Gln Leu Asp His Cys Val Phe Thr Gln Arg Lys Ile Thr Arg 
65                  70                  75                  80  


Pro Ser Gln Arg Pro Lys Thr Pro Pro Thr Asp Thr Ile Leu Tyr Thr 
                85                  90                  95      


Glu Leu Pro Asn Ala Lys Pro Arg Ser Lys Val Val Ser Cys Pro 
            100                 105                 110     


<210>  27
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIR3DL3 endodomain

<400>  27

Lys Asp Pro Gly Asn Ser Arg His Leu His Val Leu Ile Gly Thr Ser 
1               5                   10                  15      


Val Val Ile Ile Pro Phe Ala Ile Leu Leu Phe Phe Leu Leu His Arg 
            20                  25                  30          


Trp Cys Ala Asn Lys Lys Asn Ala Val Val Met Asp Gln Glu Pro Ala 
        35                  40                  45              


Gly Asn Arg Thr Val Asn Arg Glu Asp Ser Asp Glu Gln Asp Pro Gln 
    50                  55                  60                  


Glu Val Thr Tyr Ala Gln Leu Asn His Cys Val Phe Thr Gln Arg Lys 
65                  70                  75                  80  


Ile Thr Arg Pro Ser Gln Arg Pro Lys Thr Pro Pro Thr Asp Thr Ser 
                85                  90                  95      


Val 
    


<210>  28
<211>  807
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PTPN6-CD45 fusion protein

<400>  28

Trp Tyr His Gly His Met Ser Gly Gly Gln Ala Glu Thr Leu Leu Gln 
1               5                   10                  15      


Ala Lys Gly Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Leu Ser Gln 
            20                  25                  30          


Pro Gly Asp Phe Val Leu Ser Val Leu Ser Asp Gln Pro Lys Ala Gly 
        35                  40                  45              


Pro Gly Ser Pro Leu Arg Val Thr His Ile Lys Val Met Cys Glu Gly 
    50                  55                  60                  


Gly Arg Tyr Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Leu Thr Asp 
65                  70                  75                  80  


Leu Val Glu His Phe Lys Lys Thr Gly Ile Glu Glu Ala Ser Gly Ala 
                85                  90                  95      


Phe Val Tyr Leu Arg Gln Pro Tyr Lys Ile Tyr Asp Leu His Lys Lys 
            100                 105                 110         


Arg Ser Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp 
        115                 120                 125             


Glu Lys Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu 
    130                 135                 140                 


Glu Thr Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala 
145                 150                 155                 160 


Glu Phe Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu 
                165                 170                 175     


Ala Arg Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu 
            180                 185                 190         


Pro Tyr Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala 
        195                 200                 205             


Gly Ser Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro 
    210                 215                 220                 


Arg Lys Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp 
225                 230                 235                 240 


Phe Trp Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val 
                245                 250                 255     


Thr Arg Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro 
            260                 265                 270         


Ser Met Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile 
        275                 280                 285             


Asn Gln His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile 
    290                 295                 300                 


Val Asn Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln 
305                 310                 315                 320 


Phe Thr Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu 
                325                 330                 335     


Leu Lys Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly 
            340                 345                 350         


Pro Ile Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr 
        355                 360                 365             


Ile Gly Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val 
    370                 375                 380                 


Asp Val Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met 
385                 390                 395                 400 


Val Gln Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu 
                405                 410                 415     


Tyr Asn Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro 
            420                 425                 430         


Tyr Leu His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro 
        435                 440                 445             


Leu Glu Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr 
    450                 455                 460                 


Gln His Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser 
465                 470                 475                 480 


Asn Val Ile Pro Tyr Asp Tyr Asn Arg Val Leu Lys His Glu Leu Glu 
                485                 490                 495     


Met Ser Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp 
            500                 505                 510         


Ser Asp Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met 
        515                 520                 525             


Ser Tyr Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys 
    530                 535                 540                 


Glu Thr Ile Gly Asp Phe Met Ile Gln Arg Lys Val Lys Val Ile Val 
545                 550                 555                 560 


Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys Ala Gln Tyr 
                565                 570                 575     


Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val Asp Leu Lys 
            580                 585                 590         


Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe Glu Leu Arg 
        595                 600                 605             


His Ser Lys Arg Lys Asp Ser Arg Thr Val Tyr Gln Tyr Gln Tyr Thr 
    610                 615                 620                 


Asn Trp Ser Val Glu Gln Leu Pro Ala Glu Pro Lys Glu Leu Ile Ser 
625                 630                 635                 640 


Met Ile Gln Val Val Lys Gln Lys Leu Pro Gln Lys Asn Ser Ser Glu 
                645                 650                 655     


Gly Asn Lys His His Lys Ser Thr Pro Leu Leu Ile His Cys Arg Asp 
            660                 665                 670         


Gly Ser Gln Gln Thr Gly Ile Phe Cys Ala Leu Leu Asn Leu Leu Glu 
        675                 680                 685             


Ser Ala Glu Thr Glu Glu Val Val Asp Ile Phe Gln Val Val Lys Ala 
    690                 695                 700                 


Leu Arg Lys Ala Arg Pro Gly Met Val Ser Thr Phe Glu Gln Tyr Gln 
705                 710                 715                 720 


Phe Leu Tyr Asp Val Ile Ala Ser Thr Tyr Pro Ala Gln Asn Gly Gln 
                725                 730                 735     


Val Lys Lys Asn Asn His Gln Glu Asp Lys Ile Glu Phe Asp Asn Glu 
            740                 745                 750         


Val Asp Lys Val Lys Gln Asp Ala Asn Cys Val Asn Pro Leu Gly Ala 
        755                 760                 765             


Pro Glu Lys Leu Pro Glu Ala Lys Glu Gln Ala Glu Gly Ser Glu Pro 
    770                 775                 780                 


Thr Ser Gly Thr Glu Gly Pro Glu His Ser Val Asn Gly Pro Ala Ser 
785                 790                 795                 800 


Pro Ala Leu Asn Gln Gly Ser 
                805         


<210>  29
<211>  434
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PTPN6-CD148 fusion protein

<400>  29

Glu Thr Leu Leu Gln Ala Lys Gly Glu Pro Trp Thr Phe Leu Val Arg 
1               5                   10                  15      


Glu Ser Leu Ser Gln Pro Gly Asp Phe Val Leu Ser Val Leu Ser Asp 
            20                  25                  30          


Gln Pro Lys Ala Gly Pro Gly Ser Pro Leu Arg Val Thr His Ile Lys 
        35                  40                  45              


Val Met Cys Glu Gly Gly Arg Tyr Thr Val Gly Gly Leu Glu Thr Phe 
    50                  55                  60                  


Asp Ser Leu Thr Asp Leu Val Glu His Phe Lys Lys Thr Gly Ile Glu 
65                  70                  75                  80  


Glu Ala Ser Gly Ala Phe Val Tyr Leu Arg Gln Pro Tyr Arg Lys Lys 
                85                  90                  95      


Arg Lys Asp Ala Lys Asn Asn Glu Val Ser Phe Ser Gln Ile Lys Pro 
            100                 105                 110         


Lys Lys Ser Lys Leu Ile Arg Val Glu Asn Phe Glu Ala Tyr Phe Lys 
        115                 120                 125             


Lys Gln Gln Ala Asp Ser Asn Cys Gly Phe Ala Glu Glu Tyr Glu Asp 
    130                 135                 140                 


Leu Lys Leu Val Gly Ile Ser Gln Pro Lys Tyr Ala Ala Glu Leu Ala 
145                 150                 155                 160 


Glu Asn Arg Gly Lys Asn Arg Tyr Asn Asn Val Leu Pro Tyr Asp Ile 
                165                 170                 175     


Ser Arg Val Lys Leu Ser Val Gln Thr His Ser Thr Asp Asp Tyr Ile 
            180                 185                 190         


Asn Ala Asn Tyr Met Pro Gly Tyr His Ser Lys Lys Asp Phe Ile Ala 
        195                 200                 205             


Thr Gln Gly Pro Leu Pro Asn Thr Leu Lys Asp Phe Trp Arg Met Val 
    210                 215                 220                 


Trp Glu Lys Asn Val Tyr Ala Ile Ile Met Leu Thr Lys Cys Val Glu 
225                 230                 235                 240 


Gln Gly Arg Thr Lys Cys Glu Glu Tyr Trp Pro Ser Lys Gln Ala Gln 
                245                 250                 255     


Asp Tyr Gly Asp Ile Thr Val Ala Met Thr Ser Glu Ile Val Leu Pro 
            260                 265                 270         


Glu Trp Thr Ile Arg Asp Phe Thr Val Lys Asn Ile Gln Thr Ser Glu 
        275                 280                 285             


Ser His Pro Leu Arg Gln Phe His Phe Thr Ser Trp Pro Asp His Gly 
    290                 295                 300                 


Val Pro Asp Thr Thr Asp Leu Leu Ile Asn Phe Arg Tyr Leu Val Arg 
305                 310                 315                 320 


Asp Tyr Met Lys Gln Ser Pro Pro Glu Ser Pro Ile Leu Val His Cys 
                325                 330                 335     


Ser Ala Gly Val Gly Arg Thr Gly Thr Phe Ile Ala Ile Asp Arg Leu 
            340                 345                 350         


Ile Tyr Gln Ile Glu Asn Glu Asn Thr Val Asp Val Tyr Gly Ile Val 
        355                 360                 365             


Tyr Asp Leu Arg Met His Arg Pro Leu Met Val Gln Thr Glu Asp Gln 
    370                 375                 380                 


Tyr Val Phe Leu Asn Gln Cys Val Leu Asp Ile Val Arg Ser Gln Lys 
385                 390                 395                 400 


Asp Ser Lys Val Asp Leu Ile Tyr Gln Asn Thr Thr Ala Met Thr Ile 
                405                 410                 415     


Tyr Glu Asn Leu Ala Pro Val Thr Thr Phe Gly Lys Thr Asn Gly Tyr 
            420                 425                 430         


Ile Ala 
        


<210>  30
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  marker/suicide polypeptide

<400>  30

Cys Pro Tyr Ser Asn Pro Ser Leu Cys Ser Gly Gly Gly Gly Ser Glu 
1               5                   10                  15      


Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Pro 
            20                  25                  30          


Ala Lys Pro Thr Thr Thr Ala Cys Pro Tyr Ser Asn Pro Ser Leu Cys 
        35                  40                  45              


Ser Gly Gly Gly Gly Ser Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
    50                  55                  60                  


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
65                  70                  75                  80  


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
                85                  90                  95      


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
            100                 105                 110         


Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val 
        115                 120                 125             


Cys Lys Cys Pro Arg Pro Val Val 
    130                 135     


<210>  31
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage sequence

<400>  31

Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
1               5                   10                  15      


Pro Gly Gly 
            


<210>  32
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A-like sequence

<400>  32

Tyr His Ala Asp Tyr Tyr Lys Gln Arg Leu Ile His Asp Val Glu Met 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  33
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A-like sequence

<400>  33

His Tyr Ala Gly Tyr Phe Ala Asp Leu Leu Ile His Asp Ile Glu Thr 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  34
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A-like sequence

<400>  34

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  35
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A-like sequence

<400>  35

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  36
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A-like sequence

<400>  36

Ala Ala Arg Gln Met Leu Leu Leu Leu Ser Gly Asp Val Glu Thr Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  37
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A-like sequence

<400>  37

Arg Ala Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  38
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A-like sequence

<400>  38

Thr Arg Ala Glu Ile Glu Asp Glu Leu Ile Arg Ala Gly Ile Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  39
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A-like sequence

<400>  39

Thr Arg Ala Glu Ile Glu Asp Glu Leu Ile Arg Ala Asp Ile Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  40
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A-like sequence

<400>  40

Ala Lys Phe Gln Ile Asp Lys Ile Leu Ile Ser Gly Asp Val Glu Leu 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  41
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A-like sequence

<400>  41

Ser Ser Ile Ile Arg Thr Lys Met Leu Val Ser Gly Asp Val Glu Glu 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  42
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A-like sequence

<400>  42

Cys Asp Ala Gln Arg Gln Lys Leu Leu Leu Ser Gly Asp Ile Glu Gln 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  43
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A-like sequence

<400>  43

Tyr Pro Ile Asp Phe Gly Gly Phe Leu Val Lys Ala Asp Ser Glu Phe 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  44
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage sequence

<400>  44

Val Thr Glu Leu Leu Tyr Arg Met Lys Arg Ala Glu Thr Tyr Cys Pro 
1               5                   10                  15      


Arg Pro Leu Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys Ile 
            20                  25                  30          


Val Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
        35                  40                  45              


Gly Asp Val Glu Ser Asn Pro Gly Pro 
    50                  55          


<210>  45
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage sequence

<400>  45

Leu Leu Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys Ile Val 
1               5                   10                  15      


Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
            20                  25                  30          


Asp Val Glu Ser Asn Pro Gly Pro 
        35                  40  


<210>  46
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage sequence

<400>  46

Glu Ala Arg His Lys Gln Lys Ile Val Ala Pro Val Lys Gln Thr Leu 
1               5                   10                  15      


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
            20                  25                  30          


Pro 
    


<210>  47
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage sequence

<400>  47

Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
1               5                   10                  15      


Asp Val Glu Ser Asn Pro Gly Pro 
            20                  


<210>  48
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  48

Ser Gly Gly Gly Ser 
1               5   


<210>  49
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  intracellular retention signal


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  49

Asn Pro Phe Xaa 
1               


<210>  50
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  intracellular retention signal

<400>  50

Lys Asp Glu Leu 
1               


<210>  51
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  intracellular retention signal


<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  51

Lys Lys Xaa Xaa 
1               


<210>  52
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  intracellular retention signal


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  52

Lys Xaa Lys Xaa Xaa 
1               5   


<210>  53
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  intracellular retention signal


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  53

Asn Pro Xaa Tyr 
1               


<210>  54
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  intracellular retention signal


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is an amino acid with a bulky hydrophobic side chain

<400>  54

Tyr Xaa Xaa Xaa 
1               


<210>  55
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  intracellular retention signal


<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  55

Asp Glu Xaa Xaa Xaa Leu Leu Ile 
1               5               


<210>  56
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  intracellular retention signal


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  56

Asp Xaa Xaa Leu Leu 
1               5   


<210>  57
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  intracellular retention signal

<400>  57

Asp Pro Phe Trp 
1               


<210>  58
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  intracellular retention signal


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  58

Phe Xaa Asp Xaa Phe 
1               5   


<210>  59
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  intracellular retention signal


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is an amino acid with a bulky hydrophobic side chain

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is an amino acid with a bulky hydrophobic side chain

<400>  59

Leu Xaa Xaa Xaa Asp Glu 
1               5       


<210>  60
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  intracellular retention signal

<400>  60

Leu Leu Asp Leu Leu 
1               5   


<210>  61
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  intracellular retention signal

<400>  61

Pro Trp Asp Leu Trp 
1               5   


<210>  62
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  62

Met Glu Thr Asp Thr Leu Ile Leu Trp Val Leu Leu Leu Leu Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  63
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide derived from Human CD8a

<400>  63

Met Ser Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  64
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv aCD19

<400>  64

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Lys Ala Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser 
    130                 135                 140                 


Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp 
145                 150                 155                 160 


Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp 
                165                 170                 175     


Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu 
            180                 185                 190         


Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe 
        195                 200                 205             


Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys 
    210                 215                 220                 


Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Ser Val Thr Val Ser 
                245             


<210>  65
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  65

Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
1               5                   10                  15      


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            20                  25                  30          


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        35                  40                  45          


<210>  66
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  66

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  67
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  67

Arg Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
1               5                   10                  15      


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            20                  25                  30          


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        35                  40                  45              


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  68
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A peptide

<400>  68

Arg Ala Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  69
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide derived from mouse Ig kappa

<400>  69

Met Ala Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala 
        


<210>  70
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv aCD33

<400>  70

Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Tyr 
            20                  25                  30          


Phe Asn Leu Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Thr Asn Arg Leu Ala Asp Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Gln Tyr Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr Lys Asn Tyr 
                85                  90                  95      


Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Arg Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    130                 135                 140                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
145                 150                 155                 160 


Thr Leu Ser Asn Tyr Gly Met His Trp Ile Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Gly Leu Glu Trp Val Ser Ser Ile Ser Leu Asn Gly Gly Ser Thr Tyr 
            180                 185                 190         


Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        195                 200                 205             


Lys Ser Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Ala Gln Asp Ala Tyr Thr Gly Gly Tyr Phe 
225                 230                 235                 240 


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Met 
                245                 250                 


<210>  71
<211>  43
<212>  PRT
<213>  Mus musculus

<400>  71

Thr Thr Thr Lys Pro Val Leu Arg Thr Pro Ser Pro Val His Pro Thr 
1               5                   10                  15      


Gly Thr Ser Gln Pro Gln Arg Pro Glu Asp Cys Arg Pro Arg Gly Ser 
            20                  25                  30          


Val Lys Gly Thr Gly Leu Asp Phe Ala Cys Asp 
        35                  40              


<210>  72
<211>  22
<212>  PRT
<213>  Mus musculus

<400>  72

Ile Tyr Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Leu Leu Leu Ser 
1               5                   10                  15      


Leu Ile Ile Thr Leu Ile 
            20          


<210>  73
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated mouse CD8a intracellular domain

<400>  73

Cys Tyr His Arg Ser Arg Lys Arg Val Cys Lys 
1               5                   10      


<210>  74
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated human SHP-1

<400>  74

Phe Trp Glu Glu Phe Glu Ser Leu Gln Lys Gln Glu Val Lys Asn Leu 
1               5                   10                  15      


His Gln Arg Leu Glu Gly Gln Arg Pro Glu Asn Lys Gly Lys Asn Arg 
            20                  25                  30          


Tyr Lys Asn Ile Leu Pro Phe Asp His Ser Arg Val Ile Leu Gln Gly 
        35                  40                  45              


Arg Asp Ser Asn Ile Pro Gly Ser Asp Tyr Ile Asn Ala Asn Tyr Ile 
    50                  55                  60                  


Lys Asn Gln Leu Leu Gly Pro Asp Glu Asn Ala Lys Thr Tyr Ile Ala 
65                  70                  75                  80  


Ser Gln Gly Cys Leu Glu Ala Thr Val Asn Asp Phe Trp Gln Met Ala 
                85                  90                  95      


Trp Gln Glu Asn Ser Arg Val Ile Val Met Thr Thr Arg Glu Val Glu 
            100                 105                 110         


Lys Gly Arg Asn Lys Cys Val Pro Tyr Trp Pro Glu Val Gly Met Gln 
        115                 120                 125             


Arg Ala Tyr Gly Pro Tyr Ser Val Thr Asn Cys Gly Glu His Asp Thr 
    130                 135                 140                 


Thr Glu Tyr Lys Leu Arg Thr Leu Gln Val Ser Pro Leu Asp Asn Gly 
145                 150                 155                 160 


Asp Leu Ile Arg Glu Ile Trp His Tyr Gln Tyr Leu Ser Trp Pro Asp 
                165                 170                 175     


His Gly Val Pro Ser Glu Pro Gly Gly Val Leu Ser Phe Leu Asp Gln 
            180                 185                 190         


Ile Asn Gln Arg Gln Glu Ser Leu Pro His Ala Gly Pro Ile Ile Val 
        195                 200                 205             


His Cys Ser Ala Gly Ile Gly Arg Thr Gly Thr Ile Ile Val Ile Asp 
    210                 215                 220                 


Met Leu Met Glu Asn Ile Ser Thr Lys Gly Leu Asp Cys Asp Ile Asp 
225                 230                 235                 240 


Ile Gln Lys Thr Ile Gln Met Val Arg Ala Gln Arg Ser Gly Met Val 
                245                 250                 255     


Gln Thr Glu Ala Gln Tyr Lys Phe Ile Tyr Val Ala Ile Ala Gln Phe 
            260                 265                 270         


Ile Glu Thr Thr Lys Lys Lys Leu 
        275                 280 


<210>  75
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  75

Ile Leu Ile Gly Val Ser Val Val Phe Leu Phe Cys Leu Leu Leu Leu 
1               5                   10                  15      


Val Leu Phe Cys Leu 
            20      


<210>  76
<211>  4
<212>  PRT
<213>  Mus musculus

<400>  76

Met Glu Thr Asp 
1               


<210>  77
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  77

Thr Leu Ile Leu Trp Val Leu Leu Leu Leu Val 
1               5                   10      


<210>  78
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  78

Pro Gly Ser Thr Gly 
1               5   


<210>  79
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu 
1               5                   10                  15      


Ala Leu Leu Pro Ala Ala Thr Gln Gly 
            20                  25  


<210>  80
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe Leu Asp 
1               5                   10                  15      


Thr Glu Val Phe Val Thr Gly 
            20              


<210>  81
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  82
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Thr Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val 
            20      


<210>  83
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn 
1               5                   10                  15      


Val Ser Ser Lys Gly Ala Val Ser 
            20                  


<210>  84
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Cys Leu Gly 
            20                  


<210>  85
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Ala Gly Pro Pro Arg Leu Leu Leu Leu Pro Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Arg Gly Leu Pro Gly Ala Leu Ala 
            20                  25  


<210>  86
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Ser Ala Pro Lys Leu Leu Ser Leu Gly Cys Ile Phe Phe Pro Leu 
1               5                   10                  15      


Leu Leu Phe Gln Gln Ala Arg Ala 
            20                  


<210>  87
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Arg Phe Phe Val Pro Leu Phe Leu Val Gly Ile Leu Phe Pro Ala 
1               5                   10                  15      


Ile Leu Ala 
            


<210>  88
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Pro Gly Phe Leu Val Arg Ile Leu Pro Leu Leu Leu Val Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Thr Arg Gly 
            20              


<210>  89
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Lys Arg Phe Leu Phe Leu Leu Leu Thr Ile Ser Leu Leu Val Met 
1               5                   10                  15      


Val Gln Ile Gln Thr Gly Leu Ser 
            20                  


<210>  90
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Gln Gly Pro Pro Leu Leu Thr Ala Ala His Leu Leu Cys Val Cys 
1               5                   10                  15      


Thr Ala Ala Leu Ala 
            20      


<210>  91
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Gly Pro Thr Ser Gly Pro Ser Leu Leu Leu Leu Leu Leu Thr His 
1               5                   10                  15      


Leu Pro Leu Ala Leu Gly 
            20          


<210>  92
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Gln Pro Ile Leu Leu Leu Leu Ala Phe Leu Leu Leu Pro Arg Ala 
1               5                   10                  15      


Asp Ala 
        


<210>  93
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Arg 
            20  


<210>  94
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly 
            20  


<210>  95
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Ala Trp Ala Pro Leu Leu Leu Thr Leu Leu Ala His Cys Thr Asp 
1               5                   10                  15      


Cys Trp Ala 
            


<210>  96
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Leu Lys Pro Ser Leu Pro Phe Thr Ser Leu Leu Phe Leu Gln Leu 
1               5                   10                  15      


Pro Leu Leu Gly Val Gly 
            20          


<210>  97
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  97

Met Ala Trp Ala Ser Arg Leu Gly Leu Leu Leu Ala Leu Leu Leu Pro 
1               5                   10                  15      


Val Val Gly Ala 
            20  


<210>  98
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Gly Val Pro Arg Pro Gln Pro Trp Ala Leu Gly Leu Leu Leu Phe 
1               5                   10                  15      


Leu Leu Pro Gly Ser Leu Gly 
            20              


<210>  99
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITAM motif


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa may be Leu or Ile

<400>  99

Tyr Xaa Xaa Xaa 
1               


<210>  100
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  basic amino acid furin target sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa may be Arg or Lys

<400>  100

Arg Xaa Xaa Arg 
1               


<210>  101
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus Tobacco Etch Virus (TEV) cleavage site

<400>  101

Glu Asn Leu Tyr Phe Gln Ser 
1               5           


<210>  102
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif involved in cleavage activity


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  102

Asp Xaa Glu Xaa Asn Pro Gly Pro 
1               5               


<210>  103
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa may be Ile, Val, Met or Ser

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa may be Thr, Met, Ser, Leu, Glu, Gln or Phe

<400>  103

Asp Xaa Glu Xaa Asn Pro Gly Pro 
1               5               


<210>  104
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal signal, motif of postassium channels


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  104

Arg Xaa Arg Arg 
1               


<210>  105
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  105

Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr 
1               5                   10          


<210>  106
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  106

Val Glu Ile Gly Asn Pro Thr Tyr Lys Met Tyr Glu 
1               5                   10          


<210>  107
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  107

Thr Asn Phe Thr Asn Pro Val Tyr Ala Thr Leu Tyr 
1               5                   10          


<210>  108
<211>  12
<212>  PRT
<213>  Drosophila sp.

<400>  108

Gly Asn Phe Ala Asn Pro Val Tyr Glu Ser Met Tyr 
1               5                   10          


<210>  109
<211>  12
<212>  PRT
<213>  Caenorhabditis elegans

<400>  109

Thr Thr Phe Thr Asn Pro Val Tyr Glu Leu Glu Asp 
1               5                   10          


<210>  110
<211>  12
<212>  PRT
<213>  Caenorhabditis elegans

<400>  110

Leu Arg Val Asp Asn Pro Leu Tyr Asp Pro Asp Ser 
1               5                   10          


<210>  111
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  111

Ile Ile Phe Glu Asn Pro Met Tyr Ser Ala Arg Asp 
1               5                   10          


<210>  112
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  112

Thr Asn Phe Glu Asn Pro Ile Tyr Ala Gln Met Glu 
1               5                   10          


<210>  113
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  113

Asp Thr Gly Glu Asn Pro Ile Tyr Lys Ser Ala Val 
1               5                   10          


<210>  114
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  114

Thr Thr Val Val Asn Pro Lys Tyr Glu Gly Lys 
1               5                   10      


<210>  115
<211>  12
<212>  PRT
<213>  Drosophila sp.

<400>  115

Trp Asp Thr Glu Asn Pro Ile Tyr Lys Gln Ala Thr 
1               5                   10          


<210>  116
<211>  11
<212>  PRT
<213>  Drosophila sp.

<400>  116

Ser Thr Phe Lys Asn Pro Met Tyr Ala Gly Lys 
1               5                   10      


<210>  117
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  117

His Gly Tyr Glu Asn Pro Thr Tyr Arg Phe Leu Glu 
1               5                   10          


<210>  118
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  118

Asn Gly Tyr Glu Asn Pro Thr Tyr Lys Phe Phe Glu 
1               5                   10          


<210>  119
<211>  12
<212>  PRT
<213>  Drosophila sp.

<400>  119

Asn Gly Tyr Glu Asn Pro Thr Tyr Lys Tyr Phe Glu 
1               5                   10          


<210>  120
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  120

Tyr Ala Ser Ser Asn Pro Glu Tyr Leu Ser Ala Ser 
1               5                   10          


<210>  121
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  121

Gly Ser Val Gln Asn Pro Val Tyr His Asn Gln Pro 
1               5                   10          


<210>  122
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  122

Thr Ala Val Gly Asn Pro Glu Tyr Leu Asn Thr Val 
1               5                   10          


<210>  123
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  123

Ile Ser Leu Asp Asn Pro Asp Tyr Gln Gln Asp Phe 
1               5                   10          


<210>  124
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  124

Arg Lys Arg Ser His Ala Gly Tyr Gln Thr Ile 
1               5                   10      


<210>  125
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  125

Lys His His His Ala Gly Tyr Glu Gln Phe 
1               5                   10  


<210>  126
<211>  11
<212>  PRT
<213>  Gallus gallus

<400>  126

Lys Lys His His Asn Thr Gly Tyr Glu Gln Phe 
1               5                   10      


<210>  127
<211>  11
<212>  PRT
<213>  Gallus gallus

<400>  127

Arg Arg Lys Ser Arg Thr Gly Tyr Gln Ser Val 
1               5                   10      


<210>  128
<211>  11
<212>  PRT
<213>  Gallus gallus

<400>  128

Arg Arg Lys Ser Tyr Ala Gly Tyr Gln Thr Leu 
1               5                   10      


<210>  129
<211>  12
<212>  PRT
<213>  Drosophila sp.

<400>  129

Arg Arg Arg Ser Thr Ser Arg Gly Tyr Met Ser Phe 
1               5                   10          


<210>  130
<211>  11
<212>  PRT
<213>  Lumbricus terrestris

<400>  130

Arg Lys Arg Ser Arg Arg Gly Tyr Glu Ser Val 
1               5                   10      


<210>  131
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  131

Lys Ser Ile Arg Ser Gly Tyr Glu Val Met 
1               5                   10  


<210>  132
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  132

His Cys Gly Gly Pro Arg Pro Gly Tyr Glu Thr Leu 
1               5                   10          


<210>  133
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  133

His Cys Arg Thr Arg Arg Ala Glu Tyr Glu Thr Leu 
1               5                   10          


<210>  134
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  134

Arg Arg Arg Pro Ser Ala Tyr Gln Ala Leu 
1               5                   10  


<210>  135
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  135

Arg Arg Arg Ser Tyr Gln Asn Ile Pro 
1               5                   


<210>  136
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  136

Lys Lys His Cys Ser Tyr Gln Asp Ile Leu 
1               5                   10  


<210>  137
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  137

Arg Arg Arg Ser Ala Tyr Gln Asp Ile Arg 
1               5                   10  


<210>  138
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  138

Arg Lys Arg Arg Arg Ser Tyr Gln Asp Ile Met 
1               5                   10      


<210>  139
<211>  13
<212>  PRT
<213>  Rattus norvegicus

<400>  139

Lys Phe Cys Lys Ser Lys Glu Arg Asn Tyr His Thr Leu 
1               5                   10              


<210>  140
<211>  14
<212>  PRT
<213>  Drosophila sp.

<400>  140

Lys Phe Tyr Lys Ala Arg Asn Glu Arg Asn Tyr His Thr Leu 
1               5                   10                  


<210>  141
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  141

Lys Ile Arg Leu Arg Cys Gln Ser Ser Gly Tyr Gln Arg Ile 
1               5                   10                  


<210>  142
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  142

Lys Ile Arg Gln Arg His Gln Ser Ser Ala Tyr Gln Arg Ile 
1               5                   10                  


<210>  143
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  143

His Phe Cys Leu Tyr Arg Lys Arg Pro Gly Tyr Asp Gln Leu Asn 
1               5                   10                  15  


<210>  144
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  144

Ser Leu Ser Arg Gly Ser Gly Tyr Lys Glu Ile 
1               5                   10      


<210>  145
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  145

Arg Arg Leu Arg Lys Gly Tyr Thr Pro Leu Met Glu Thr 
1               5                   10              


<210>  146
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  146

Arg Arg Ala Gly His Ser Ser Tyr Thr Pro Leu Pro Gly Ser 
1               5                   10                  


<210>  147
<211>  18
<212>  PRT
<213>  Dictyostelium sp.

<400>  147

Lys Lys Leu Arg Gln Gln Lys Gln Gln Gly Tyr Gln Ala Ile Ile Asn 
1               5                   10                  15      


Asn Glu 
        


<210>  148
<211>  15
<212>  PRT
<213>  Dictyostelium sp.

<400>  148

Arg Ser Lys Ser Asn Gln Asn Gln Ser Tyr Asn Leu Ile Gln Leu 
1               5                   10                  15  


<210>  149
<211>  17
<212>  PRT
<213>  Dictyostelium sp.

<400>  149

Arg Lys Thr Phe Tyr Asn Asn Asn Gln Tyr Asn Gly Tyr Asn Ile Ile 
1               5                   10                  15      


Asn 
    


<210>  150
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  150

Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala 
1               5                   10  


<210>  151
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  151

Met Thr Lys Glu Tyr Gln Asp Leu Gln His Leu 
1               5                   10      


<210>  152
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  152

Ser Tyr Lys Tyr Ser Lys Val Asn Lys Glu 
1               5                   10  


<210>  153
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  153

Pro Ala Ala Tyr Arg Gly Val Gly Asp Asp 
1               5                   10  


<210>  154
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  154

Thr Gly Val Tyr Val Lys Met Pro Pro Thr 
1               5                   10  


<210>  155
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  155

Leu Ile Ser Tyr Lys Gly Leu Pro Pro Glu 
1               5                   10  


<210>  156
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  156

Ala Ser Asp Tyr Gln Arg Leu Asn Leu Lys Leu 
1               5                   10      


<210>  157
<211>  11
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  157

Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr 
1               5                   10      


<210>  158
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  158

Arg Met Gln Ala Gln Pro Pro Gly Tyr Arg His Val Ala Asp Gly Glu 
1               5                   10                  15      


Asp His Ala 
            


<210>  159
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dileucine-based sorting signal


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa may be Asp or Glu

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa may be Leu or Ile

<400>  159

Xaa Xaa Xaa Xaa Leu Leu Xaa 
1               5           


<210>  160
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  160

Ser Asp Lys Gln Thr Leu Leu Pro Asn 
1               5                   


<210>  161
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  161

Asp Glu Arg Ala Pro Leu Ile Arg Thr 
1               5                   


<210>  162
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  162

Gln Glu Lys Asp Pro Leu Leu Lys Asn 
1               5                   


<210>  163
<211>  9
<212>  PRT
<213>  Coturnix sp.

<400>  163

Thr Glu Arg Asn Pro Leu Leu Lys Ser 
1               5                   


<210>  164
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  164

Gly Glu Asn Ser Pro Leu Leu Ser Gly 
1               5                   


<210>  165
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  165

Glu Glu Lys Gln Pro Leu Leu Met Glu 
1               5                   


<210>  166
<211>  9
<212>  PRT
<213>  Oryzias latipes

<400>  166

Gly Glu Arg Gln Pro Leu Leu Gln Ser 
1               5                   


<210>  167
<211>  9
<212>  PRT
<213>  Gallus gallus

<400>  167

Pro Glu Ile Gln Pro Leu Leu Thr Glu 
1               5                   


<210>  168
<211>  9
<212>  PRT
<213>  Carassius auratus

<400>  168

Glu Gly Arg Gln Pro Leu Leu Gly Asp 
1               5                   


<210>  169
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  169

Glu Ala Asn Gln Pro Leu Leu Thr Asp 
1               5                   


<210>  170
<211>  9
<212>  PRT
<213>  Gallus gallus

<400>  170

Glu Leu His Gln Pro Leu Leu Thr Asp 
1               5                   


<210>  171
<211>  9
<212>  PRT
<213>  Danio rerio

<400>  171

Arg Glu Phe Glu Pro Leu Leu Asn Ala 
1               5                   


<210>  172
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  172

Glu Glu Lys Met Ala Ile Leu Met Asp 
1               5                   


<210>  173
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  173

Glu Glu Lys Leu Ala Ile Leu Ser Gln 
1               5                   


<210>  174
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  174

Ser Glu Arg Asp Val Leu Leu Asp Glu 
1               5                   


<210>  175
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  175

Ser Glu Arg Arg Asn Leu Leu Glu Asp 
1               5                   


<210>  176
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  176

Asp Asp Ser Gly Asp Leu Leu Pro Gly 
1               5                   


<210>  177
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  177

Ser Gln Ile Lys Arg Leu Leu Ser Glu 
1               5                   


<210>  178
<211>  9
<212>  PRT
<213>  Felis catus

<400>  178

Ser His Ile Lys Arg Leu Leu Ser Glu 
1               5                   


<210>  179
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  179

Arg Arg Thr Pro Ser Leu Leu Glu Gln 
1               5                   


<210>  180
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  180

His Arg Thr Pro Ser Leu Leu Glu Gln 
1               5                   


<210>  181
<211>  10
<212>  PRT
<213>  Rattus norvegicus

<400>  181

Glu Pro Arg Gly Ser Arg Leu Leu Val Arg 
1               5                   10  


<210>  182
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  182

Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
1               5                   10                  15      


Leu Gly Arg 
            


<210>  183
<211>  19
<212>  PRT
<213>  Mus musculus

<400>  183

Met Asp Asp Gln Arg Asp Leu Ile Ser Asn His Glu Gln Leu Pro Ile 
1               5                   10                  15      


Leu Gly Asn 
            


<210>  184
<211>  20
<212>  PRT
<213>  Gallus gallus

<400>  184

Met Ala Glu Glu Gln Arg Asp Leu Ile Ser Ser Asp Gly Ser Ser Gly 
1               5                   10                  15      


Val Leu Pro Ile 
            20  


<210>  185
<211>  23
<212>  PRT
<213>  Danio rerio

<400>  185

Met Glu Pro Asp His Gln Asn Glu Ser Leu Ile Gln Arg Val Pro Ser 
1               5                   10                  15      


Ala Glu Thr Ile Leu Gly Arg 
            20              


<210>  186
<211>  23
<212>  PRT
<213>  Danio rerio

<400>  186

Met Ser Ser Glu Gly Asn Glu Thr Pro Leu Ile Ser Asp Gln Ser Ser 
1               5                   10                  15      


Val Asn Met Gly Pro Gln Pro 
            20              


<210>  187
<211>  24
<212>  PRT
<213>  Trypanosoma sp.

<400>  187

Arg Pro Arg Arg Arg Thr Glu Glu Asp Glu Leu Leu Pro Glu Glu Ala 
1               5                   10                  15      


Glu Gly Leu Ile Asp Pro Gln Asn 
            20                  


<210>  188
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  188

Pro Asp Lys His Ser Leu Leu Val Gly Asp Phe Arg Glu Asp Asp Asp 
1               5                   10                  15      


Thr Ala Leu 
            


<210>  189
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  189

Thr Glu Arg Glu Arg Leu Leu Asn Phe 
1               5                   


<210>  190
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  190

Val Glu Thr Asp Asp Leu Ile Leu 
1               5               


<210>  191
<211>  7
<212>  PRT
<213>  Caenorhabditis elegans

<400>  191

Phe Glu Asn Asp Ser Leu Leu 
1               5           


<210>  192
<211>  9
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  192

Asn Glu Gln Ser Pro Leu Leu His Asn 
1               5                   


<210>  193
<211>  8
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  193

Ser Glu Gln Thr Arg Leu Val Pro 
1               5               


<210>  194
<211>  8
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  194

Glu Val Asp Leu Asp Leu Leu Lys 
1               5               


<210>  195
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  195

Ser Phe His Asp Asp Ser Asp Glu Asp Leu Leu His Ile 
1               5                   10              


<210>  196
<211>  13
<212>  PRT
<213>  Bos taurus

<400>  196

Thr Phe His Asp Asp Ser Asp Glu Asp Leu Leu His Val 
1               5                   10              


<210>  197
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  197

Ser Phe His Asp Asp Ser Asp Glu Asp Leu Leu Asn Ile 
1               5                   10              


<210>  198
<211>  13
<212>  PRT
<213>  Gallus gallus

<400>  198

Ser Phe His Asp Asp Ser Asp Glu Asp Leu Leu Asn Val 
1               5                   10              


<210>  199
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  199

Glu Glu Ser Glu Glu Arg Asp Asp His Leu Leu Pro Met 
1               5                   10              


<210>  200
<211>  13
<212>  PRT
<213>  Gallus gallus

<400>  200

Asp Glu Ser Glu Glu Arg Asp Asp His Leu Leu Pro Met 
1               5                   10              


<210>  201
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  201

Gly Tyr His Asp Asp Ser Asp Glu Asp Leu Leu Glu 
1               5                   10          


<210>  202
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  202

Ile Thr Gly Phe Ser Asp Asp Val Pro Met Val Ile Ala 
1               5                   10              


<210>  203
<211>  13
<212>  PRT
<213>  Hydra sp.

<400>  203

Ile Asn Arg Phe Ser Asp Asp Glu Pro Leu Val Val Ala 
1               5                   10              


<210>  204
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  204

Met Leu Glu Ala Ser Asp Asp Glu Ala Leu Leu Val Cys 
1               5                   10              


<210>  205
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  205

Lys Asn Glu Thr Ser Asp Asp Glu Ala Leu Leu Leu Cys 
1               5                   10              


<210>  206
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  206

Trp Val Val Glu Ala Glu Asp Glu Pro Leu Leu Ala 
1               5                   10          


<210>  207
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  207

Trp Val Ala Glu Ala Glu Asp Glu Pro Leu Leu Thr 
1               5                   10          


<210>  208
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  208

His Asp Asp Phe Ala Asp Asp Ile Ser Leu Leu Lys 
1               5                   10          


<210>  209
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  209

Gly Arg Asp Ser Pro Glu Asp His Ser Leu Leu Val Asn 
1               5                   10              


<210>  210
<211>  12
<212>  PRT
<213>  Peromyscus maniculatus

<400>  210

Val Arg Cys His Pro Glu Asp Asp Arg Leu Leu Gly 
1               5                   10          


<210>  211
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  211

His Arg Val Ser Gln Asp Asp Leu Asp Leu Leu Thr Ser 
1               5                   10              


<210>  212
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  212

Ala Ser Val Ser Leu Leu Asp Asp Glu Leu Met Ser Leu 
1               5                   10              


<210>  213
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  213

Ala Ser Ser Gly Leu Asp Asp Leu Asp Leu Leu Gly Lys 
1               5                   10              


<210>  214
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  214

Val Gln Asn Pro Ser Ala Asp Arg Asn Leu Leu Asp Leu 
1               5                   10              


<210>  215
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  215

Asn Ala Leu Ser Trp Leu Asp Glu Glu Leu Leu Cys Leu 
1               5                   10              


<210>  216
<211>  13
<212>  PRT
<213>  Drosophila sp.

<400>  216

Thr Val Asp Ser Ile Asp Asp Val Pro Leu Leu Ser Asp 
1               5                   10              


<210>  217
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  217

Gln Glu Glu Cys Pro Ser Asp Ser Glu Glu Asp Glu Gly 
1               5                   10              


<210>  218
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  218

Arg Asp Arg Asp Tyr Asp Glu Asp Asp Glu Asp Asp Ile 
1               5                   10              


<210>  219
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  219

Leu Asp Glu Thr Glu Asp Asp Glu Leu Glu Tyr Asp Asp Glu Ser 
1               5                   10                  15  


<210>  220
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  220

Lys Asp Pro Asp Glu Val Glu Thr Glu Ser 
1               5                   10  


<210>  221
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  221

His Glu Phe Gln Asp Glu Thr Asp Thr Glu Glu Glu Thr 
1               5                   10              


<210>  222
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  222

Gln Glu Lys Glu Asp Asp Gly Ser Glu Ser Glu Glu Glu Tyr 
1               5                   10                  


<210>  223
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  223

Gly Glu Asp Glu Glu Ser Glu Ser Asp 
1               5                   


<210>  224
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  224

Gly Glu Asp Ser Asp Glu Glu Pro Asp His Glu Glu 
1               5                   10          


<210>  225
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  225

Leu Glu Asp Asp Ser Asp Glu Glu Glu Asp Phe 
1               5                   10      


<210>  226
<211>  9
<212>  PRT
<213>  Human cytomegalovirus

<400>  226

Lys Asp Ser Asp Glu Glu Glu Asn Val 
1               5                   


<210>  227
<211>  13
<212>  PRT
<213>  Herpesvirus 3

<400>  227

Phe Glu Asp Ser Glu Ser Thr Asp Thr Glu Glu Glu Phe 
1               5                   10              


<210>  228
<211>  9
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  228

Leu Glu Ala Gln Glu Glu Glu Glu Val 
1               5                   


<210>  229
<211>  22
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  229

Ala Asp Asp Leu Glu Ser Gly Leu Gly Ala Glu Asp Asp Leu Glu Gln 
1               5                   10                  15      


Asp Glu Gln Leu Glu Gly 
            20          


<210>  230
<211>  12
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  230

Thr Glu Ile Asp Glu Ser Phe Glu Met Thr Asp Phe 
1               5                   10          


<210>  231
<211>  18
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  231

Thr Glu Pro Glu Glu Val Glu Asp Phe Asp Phe Asp Leu Ser Asp Glu 
1               5                   10                  15      


Asp His 
        


<210>  232
<211>  15
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  232

Phe Glu Ile Glu Glu Asp Asp Val Pro Thr Leu Glu Glu Glu His 
1               5                   10                  15  


<210>  233
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITIM conserved sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa may be Ser, Ile, Val or Leu

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa may be Ile, Val or Leu

<400>  233

Xaa Xaa Tyr Xaa Xaa Xaa 
1               5       


<210>  234
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site

<400>  234

Asp Ile Glu Thr Asn Pro Gly Pro 
1               5               


<210>  235
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site

<400>  235

Asp Val Glu Thr Asn Pro Gly Pro 
1               5               


<210>  236
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site

<400>  236

Asp Val Glu Met Asn Pro Gly Pro 
1               5               


<210>  237
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site

<400>  237

Asp Val Glu Ser Asn Pro Gly Pro 
1               5               


<210>  238
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site

<400>  238

Asp Met Glu Ser Asn Pro Gly Pro 
1               5               


<210>  239
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site

<400>  239

Asp Val Glu Leu Asn Pro Gly Pro 
1               5               


<210>  240
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site

<400>  240

Asp Val Glu Glu Asn Pro Gly Pro 
1               5               


<210>  241
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site

<400>  241

Asp Ile Glu Leu Asn Pro Gly Pro 
1               5               


<210>  242
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site

<400>  242

Asp Ile Glu Gln Asn Pro Gly Pro 
1               5               


<210>  243
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site

<400>  243

Asp Ser Glu Phe Asn Pro Gly Pro 
1               5               


<210>  244
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage sequence

<400>  244

Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  245
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage sequence

<400>  245

Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Gln Ser Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  246
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage sequence

<400>  246

Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ile Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  247
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage sequence

<400>  247

Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Phe Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  248
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage sequence

<400>  248

Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser His 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  249
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage sequence

<400>  249

Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Glu 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  250
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage sequence

<400>  250

Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Gln 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  251
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ER signal peptide

<400>  251

Lys Lys Phe Phe 
1               


<210>  252
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  252

His Arg Gln Asn Gln Ile Lys Gln Gly Pro Pro Arg Ser Lys Asp Glu 
1               5                   10                  15      


Glu Gln Lys Pro Gln Gln Arg Pro Asp Leu Ala Val Asp Val Leu Glu 
            20                  25                  30          


Arg Thr Ala Asp Lys Ala Thr Val Asn Gly Leu Pro Glu Lys Asp Arg 
        35                  40                  45              


Glu Thr Asp Thr Ser Ala Leu Ala Ala Gly Ser Ser Gln Glu Val Thr 
    50                  55                  60                  


Tyr Ala Gln Leu Asp His Trp Ala Leu Thr Gln Arg Thr Ala Arg Ala 
65                  70                  75                  80  


Val Ser Pro Gln Ser Thr Lys Pro Met Ala Glu Ser Ile Thr Tyr Ala 
                85                  90                  95      


Ala Val Ala Arg His 
            100     


<210>  253
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal SH2 domain derived from SHP-1

<400>  253

Trp Tyr His Gly His Met Ser Gly Gly Gln Ala Glu Thr Leu Leu Gln 
1               5                   10                  15      


Ala Lys Gly Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Leu Ser Gln 
            20                  25                  30          


Pro Gly Asp Phe Val Leu Ser Val Leu Ser Asp Gln Pro Lys Ala Gly 
        35                  40                  45              


Pro Gly Ser Pro Leu Arg Val Thr His Ile Lys Val Met Cys Glu Gly 
    50                  55                  60                  


Gly Arg Tyr Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Leu Thr Asp 
65                  70                  75                  80  


Leu Val Glu His Phe Lys Lys Thr Gly Ile Glu Glu Ala Ser Gly Ala 
                85                  90                  95      


Phe Val Tyr Leu Arg Gln Pro Tyr 
            100                 


<210>  254
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated human CD148 intracellular domain

<400>  254

Phe Glu Ala Tyr Phe Lys Lys Gln Gln Ala Asp Ser Asn Cys Gly Phe 
1               5                   10                  15      


Ala Glu Glu Tyr Glu Asp Leu Lys Leu Val Gly Ile Ser Gln Pro Lys 
            20                  25                  30          


Tyr Ala Ala Glu Leu Ala Glu Asn Arg Gly Lys Asn Arg Tyr Asn Asn 
        35                  40                  45              


Val Leu Pro Tyr Asp Ile Ser Arg Val Lys Leu Ser Val Gln Thr His 
    50                  55                  60                  


Ser Thr Asp Asp Tyr Ile Asn Ala Asn Tyr Met Pro Gly Tyr His Ser 
65                  70                  75                  80  


Lys Lys Asp Phe Ile Ala Thr Gln Gly Pro Leu Pro Asn Thr Leu Lys 
                85                  90                  95      


Asp Phe Trp Arg Met Val Trp Glu Lys Asn Val Tyr Ala Ile Ile Met 
            100                 105                 110         


Leu Thr Lys Cys Val Glu Gln Gly Arg Thr Lys Cys Glu Glu Tyr Trp 
        115                 120                 125             


Pro Ser Lys Gln Ala Gln Asp Tyr Gly Asp Ile Thr Val Ala Met Thr 
    130                 135                 140                 


Ser Glu Ile Val Leu Pro Glu Trp Thr Ile Arg Asp Phe Thr Val Lys 
145                 150                 155                 160 


Asn Ile Gln Thr Ser Glu Ser His Pro Leu Arg Gln Phe His Phe Thr 
                165                 170                 175     


Ser Trp Pro Asp His Gly Val Pro Asp Thr Thr Asp Leu Leu Ile Asn 
            180                 185                 190         


Phe Arg Tyr Leu Val Arg Asp Tyr Met Lys Gln Ser Pro Pro Glu Ser 
        195                 200                 205             


Pro Ile Leu Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Phe 
    210                 215                 220                 


Ile Ala Ile Asp Arg Leu Ile Tyr Gln Ile Glu Asn Glu Asn Thr Val 
225                 230                 235                 240 


Asp Val Tyr Gly Ile Val Tyr Asp Leu Arg Met His Arg Pro Leu Met 
                245                 250                 255     


Val Gln Thr Glu Asp Gln Tyr Val Phe Leu Asn Gln Cys Val Leu Asp 
            260                 265                 270         


Ile Val Arg Ser Gln Lys Asp Ser Lys Val Asp Leu Ile Tyr Gln Asn 
        275                 280                 285             


Thr Thr Ala Met Thr Ile Tyr Glu Asn Leu Ala Pro Val Thr Thr Phe 
    290                 295                 300                 


Gly Lys Thr Asn Gly Tyr Ile Ala Ser Gly Ser 
305                 310                 315 


<210>  255
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  intracellular retention signal

<400>  255

His Asp Glu Leu 
1               


