                         SEQUENCE LISTING

<110>  Editas Medicine
       Jayaram, Hari
       Selleck, William  Jr.
 
<120>  Evaluation of Cas9 molecule/guide RNA molecule complexes

<130>  118945.8008.WO00 (EM050PCT)

<150>  US 62/152,473
<151>  2015-04-24

<160>  210   

<170>  PatentIn version 3.5

<210>  1
<211>  1345
<212>  PRT
<213>  Streptococcus mutans


<220>
<221>  misc_feature
<222>  (10)..(21)
<223>  N-terminal RuvC-like domain

<220>
<221>  misc_feature
<222>  (759)..(766)
<223>  RuvC-like domain

<220>
<221>  misc_feature
<222>  (837)..(863)
<223>  HNH-like domain

<220>
<221>  misc_feature
<222>  (982)..(989)
<223>  RuvC-like domain

<400>  1

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Gly Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Asn  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  2
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes


<220>
<221>  misc_feature
<222>  (10)..(21)
<223>  N-terminal RuvC-like domain

<220>
<221>  misc_feature
<222>  (759)..(766)
<223>  RuvC-like domain

<220>
<221>  misc_feature
<222>  (837)..(863)
<223>  HNH-like domain

<220>
<221>  misc_feature
<222>  (982)..(989)
<223>  RuvC-like domain

<400>  2

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  3
<211>  4107
<212>  DNA
<213>  Streptococcus pyogenes

<400>  3
atggataaaa agtacagcat cgggctggac atcggtacaa actcagtggg gtgggccgtg       60

attacggacg agtacaaggt accctccaaa aaatttaaag tgctgggtaa cacggacaga      120

cactctataa agaaaaatct tattggagcc ttgctgttcg actcaggcga gacagccgaa      180

gccacaaggt tgaagcggac cgccaggagg cggtatacca ggagaaagaa ccgcatatgc      240

tacctgcaag aaatcttcag taacgagatg gcaaaggttg acgatagctt tttccatcgc      300

ctggaagaat cctttcttgt tgaggaagac aagaagcacg aacggcaccc catctttggc      360

aatattgtcg acgaagtggc atatcacgaa aagtacccga ctatctacca cctcaggaag      420

aagctggtgg actctaccga taaggcggac ctcagactta tttatttggc actcgcccac      480

atgattaaat ttagaggaca tttcttgatc gagggcgacc tgaacccgga caacagtgac      540

gtcgataagc tgttcatcca acttgtgcag acctacaatc aactgttcga agaaaaccct      600

ataaatgctt caggagtcga cgctaaagca atcctgtccg cgcgcctctc aaaatctaga      660

agacttgaga atctgattgc tcagttgccc ggggaaaaga aaaatggatt gtttggcaac      720

ctgatcgccc tcagtctcgg actgacccca aatttcaaaa gtaacttcga cctggccgaa      780

gacgctaagc tccagctgtc caaggacaca tacgatgacg acctcgacaa tctgctggcc      840

cagattgggg atcagtacgc cgatctcttt ttggcagcaa agaacctgtc cgacgccatc      900

ctgttgagcg atatcttgag agtgaacacc gaaattacta aagcacccct tagcgcatct      960

atgatcaagc ggtacgacga gcatcatcag gatctgaccc tgctgaaggc tcttgtgagg     1020

caacagctcc ccgaaaaata caaggaaatc ttctttgacc agagcaaaaa cggctacgct     1080

ggctatatag atggtggggc cagtcaggag gaattctata aattcatcaa gcccattctc     1140

gagaaaatgg acggcacaga ggagttgctg gtcaaactta acagggagga cctgctgcgg     1200

aagcagcgga cctttgacaa cgggtctatc ccccaccaga ttcatctggg cgaactgcac     1260

gcaatcctga ggaggcagga ggatttttat ccttttctta aagataaccg cgagaaaata     1320

gaaaagattc ttacattcag gatcccgtac tacgtgggac ctctcgcccg gggcaattca     1380

cggtttgcct ggatgacaag gaagtcagag gagactatta caccttggaa cttcgaagaa     1440

gtggtggaca agggtgcatc tgcccagtct ttcatcgagc ggatgacaaa ttttgacaag     1500

aacctcccta atgagaaggt gctgcccaaa cattctctgc tctacgagta ctttaccgtc     1560

tacaatgaac tgactaaagt caagtacgtc accgagggaa tgaggaagcc ggcattcctt     1620

agtggagaac agaagaaggc gattgtagac ctgttgttca agaccaacag gaaggtgact     1680

gtgaagcaac ttaaagaaga ctactttaag aagatcgaat gttttgacag tgtggaaatt     1740

tcaggggttg aagaccgctt caatgcgtca ttggggactt accatgatct tctcaagatc     1800

ataaaggaca aagacttcct ggacaacgaa gaaaatgagg atattctcga agacatcgtc     1860

ctcaccctga ccctgttcga agacagggaa atgatagaag agcgcttgaa aacctatgcc     1920

cacctcttcg acgataaagt tatgaagcag ctgaagcgca ggagatacac aggatgggga     1980

agattgtcaa ggaagctgat caatggaatt agggataaac agagtggcaa gaccatactg     2040

gatttcctca aatctgatgg cttcgccaat aggaacttca tgcaactgat tcacgatgac     2100

tctcttacct tcaaggagga cattcaaaag gctcaggtga gcgggcaggg agactccctt     2160

catgaacaca tcgcgaattt ggcaggttcc cccgctatta aaaagggcat ccttcaaact     2220

gtcaaggtgg tggatgaatt ggtcaaggta atgggcagac ataagccaga aaatattgtg     2280

atcgagatgg cccgcgaaaa ccagaccaca cagaagggcc agaaaaatag tagagagcgg     2340

atgaagagga tcgaggaggg catcaaagag ctgggatctc agattctcaa agaacacccc     2400

gtagaaaaca cacagctgca gaacgaaaaa ttgtacttgt actatctgca gaacggcaga     2460

gacatgtacg tcgaccaaga acttgatatt aatagactgt ccgactatga cgtagaccat     2520

atcgtgcccc agtccttcct gaaggacgac tccattgata acaaagtctt gacaagaagc     2580

gacaagaaca ggggtaaaag tgataatgtg cctagcgagg aggtggtgaa aaaaatgaag     2640

aactactggc gacagctgct taatgcaaag ctcattacac aacggaagtt cgataatctg     2700

acgaaagcag agagaggtgg cttgtctgag ttggacaagg cagggtttat taagcggcag     2760

ctggtggaaa ctaggcagat cacaaagcac gtggcgcaga ttttggacag ccggatgaac     2820

acaaaatacg acgaaaatga taaactgata cgagaggtca aagttatcac gctgaaaagc     2880

aagctggtgt ccgattttcg gaaagacttc cagttctaca aagttcgcga gattaataac     2940

taccatcatg ctcacgatgc gtacctgaac gctgttgtcg ggaccgcctt gataaagaag     3000

tacccaaagc tggaatccga gttcgtatac ggggattaca aagtgtacga tgtgaggaaa     3060

atgatagcca agtccgagca ggagattgga aaggccacag ctaagtactt cttttattct     3120

aacatcatga atttttttaa gacggaaatt accctggcca acggagagat cagaaagcgg     3180

ccccttatag agacaaatgg tgaaacaggt gaaatcgtct gggataaggg cagggatttc     3240

gctactgtga ggaaggtgct gagtatgcca caggtaaata tcgtgaaaaa aaccgaagta     3300

cagaccggag gattttccaa ggaaagcatt ttgcctaaaa gaaactcaga caagctcatc     3360

gcccgcaaga aagattggga ccctaagaaa tacgggggat ttgactcacc caccgtagcc     3420

tattctgtgc tggtggtagc taaggtggaa aaaggaaagt ctaagaagct gaagtccgtg     3480

aaggaactct tgggaatcac tatcatggaa agatcatcct ttgaaaagaa ccctatcgat     3540

ttcctggagg ctaagggtta caaggaggtc aagaaagacc tcatcattaa actgccaaaa     3600

tactctctct tcgagctgga aaatggcagg aagagaatgt tggccagcgc cggagagctg     3660

caaaagggaa acgagcttgc tctgccctcc aaatatgtta attttctcta tctcgcttcc     3720

cactatgaaa agctgaaagg gtctcccgaa gataacgagc agaagcagct gttcgtcgaa     3780

cagcacaagc actatctgga tgaaataatc gaacaaataa gcgagttcag caaaagggtt     3840

atcctggcgg atgctaattt ggacaaagta ctgtctgctt ataacaagca ccgggataag     3900

cctattaggg aacaagccga gaatataatt cacctcttta cactcacgaa tctcggagcc     3960

cccgccgcct tcaaatactt tgatacgact atcgaccgga aacggtatac cagtaccaaa     4020

gaggtcctcg atgccaccct catccaccag tcaattactg gcctgtacga aacacggatc     4080

gacctctctc aactgggcgg cgactag                                         4107


<210>  4
<211>  1388
<212>  PRT
<213>  Streptococcus thermophilus


<220>
<221>  misc_feature
<222>  (10)..(21)
<223>  N-terminal RuvC-like domain

<220>
<221>  misc_feature
<222>  (760)..(767)
<223>  RuvC-like domain

<220>
<221>  misc_feature
<222>  (844)..(870)
<223>  HNH-like domain

<220>
<221>  misc_feature
<222>  (989)..(996)
<223>  RuvC-like domain

<400>  4

Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Thr Thr Asp Asn Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Ser Lys Lys Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Val Leu Leu Phe Asp Ser Gly Ile Thr Ala Glu Gly Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Thr Glu Met Ala Thr Leu Asp Asp Ala 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Pro Asp Asp Lys Arg 
            100                 105                 110         


Asp Ser Lys Tyr Pro Ile Phe Gly Asn Leu Val Glu Glu Lys Ala Tyr 
        115                 120                 125             


His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg Lys Tyr Leu Ala Asp 
    130                 135                 140                 


Ser Thr Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Phe Asn Ser 
                165                 170                 175     


Lys Asn Asn Asp Ile Gln Lys Asn Phe Gln Asp Phe Leu Asp Thr Tyr 
            180                 185                 190         


Asn Ala Ile Phe Glu Ser Asp Leu Ser Leu Glu Asn Ser Lys Gln Leu 
        195                 200                 205             


Glu Glu Ile Val Lys Asp Lys Ile Ser Lys Leu Glu Lys Lys Asp Arg 
    210                 215                 220                 


Ile Leu Lys Leu Phe Pro Gly Glu Lys Asn Ser Gly Ile Phe Ser Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Arg Lys Cys Phe 
                245                 250                 255     


Asn Leu Asp Glu Lys Ala Ser Leu His Phe Ser Lys Glu Ser Tyr Asp 
            260                 265                 270         


Glu Asp Leu Glu Thr Leu Leu Gly Tyr Ile Gly Asp Asp Tyr Ser Asp 
        275                 280                 285             


Val Phe Leu Lys Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Phe Leu Thr Val Thr Asp Asn Glu Thr Glu Ala Pro Leu Ser Ser Ala 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asn Glu His Lys Glu Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Glu Tyr Ile Arg Asn Ile Ser Leu Lys Thr Tyr Asn Glu Val Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Asp Phe Tyr Val Tyr Leu Lys Lys Leu Leu Ala Glu Phe Glu 
    370                 375                 380                 


Gly Ala Asp Tyr Phe Leu Glu Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Leu Asp Lys Gln Ala Lys Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Lys Asn Lys Glu Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala Trp 
    450                 455                 460                 


Ser Ile Arg Lys Arg Asn Glu Lys Ile Thr Pro Trp Asn Phe Glu Asp 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Ser Phe Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Asn Val Tyr Asn Glu Leu Thr Lys Val Arg 
        515                 520                 525             


Phe Ile Ala Glu Ser Met Arg Asp Tyr Gln Phe Leu Asp Ser Lys Gln 
    530                 535                 540                 


Lys Lys Asp Ile Val Arg Leu Tyr Phe Lys Asp Lys Arg Lys Val Thr 
545                 550                 555                 560 


Asp Lys Asp Ile Ile Glu Tyr Leu His Ala Ile Tyr Gly Tyr Asp Gly 
                565                 570                 575     


Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ser Ser Leu Ser Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Asn Ile Ile Asn Asp Lys Glu Phe Leu Asp Asp 
        595                 600                 605             


Ser Ser Asn Glu Ala Ile Ile Glu Glu Ile Ile His Thr Leu Thr Ile 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ser Lys Phe Glu Asn 
625                 630                 635                 640 


Ile Phe Asp Lys Ser Val Leu Lys Lys Leu Ser Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Glu 
            660                 665                 670         


Lys Ser Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ile Ser 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ala Leu Ser Phe Lys 
    690                 695                 700                 


Lys Lys Ile Gln Lys Ala Gln Ile Ile Gly Asp Glu Asp Lys Gly Asn 
705                 710                 715                 720 


Ile Lys Glu Val Val Lys Ser Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly Gly Arg Lys Pro Glu Ser Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Tyr Thr Asn Gln Gly Lys Ser Asn Ser Gln Gln Arg Leu Lys Arg 
    770                 775                 780                 


Leu Glu Lys Ser Leu Lys Glu Leu Gly Ser Lys Ile Leu Lys Glu Asn 
785                 790                 795                 800 


Ile Pro Ala Lys Leu Ser Lys Ile Asp Asn Asn Ala Leu Gln Asn Asp 
                805                 810                 815     


Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly 
            820                 825                 830         


Asp Asp Leu Asp Ile Asp Arg Leu Ser Asn Tyr Asp Ile Asp His Ile 
        835                 840                 845             


Ile Pro Gln Ala Phe Leu Lys Asp Asn Ser Ile Asp Asn Lys Val Leu 
    850                 855                 860                 


Val Ser Ser Ala Ser Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu 
865                 870                 875                 880 


Glu Val Val Lys Lys Arg Lys Thr Phe Trp Tyr Gln Leu Leu Lys Ser 
                885                 890                 895     


Lys Leu Ile Ser Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            900                 905                 910         


Gly Gly Leu Ser Pro Glu Asp Lys Ala Gly Phe Ile Gln Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Leu Leu Asp Glu 
    930                 935                 940                 


Lys Phe Asn Asn Lys Lys Asp Glu Asn Asn Arg Ala Val Arg Thr Val 
945                 950                 955                 960 


Lys Ile Ile Thr Leu Lys Ser Thr Leu Val Ser Gln Phe Arg Lys Asp 
                965                 970                 975     


Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn Asp Phe His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Val  Ala Ser Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Lys  Leu Glu Pro Glu Phe  Val Tyr Gly Asp Tyr  Pro Lys Tyr 
    1010                 1015                 1020             


Asn Ser  Phe Arg Glu Arg Lys  Ser Ala Thr Glu Lys  Val Tyr Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Ile  Phe Lys Lys Ser Ile  Ser Leu Ala 
    1040                 1045                 1050             


Asp Gly  Arg Val Ile Glu Arg  Pro Leu Ile Glu Val  Asn Glu Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ser Val Trp Asn  Lys Glu Ser Asp Leu  Ala Thr Val 
    1070                 1075                 1080             


Arg Arg  Val Leu Ser Tyr Pro  Gln Val Asn Val Val  Lys Lys Val 
    1085                 1090                 1095             


Glu Glu  Gln Asn His Gly Leu  Asp Arg Gly Lys Pro  Lys Gly Leu 
    1100                 1105                 1110             


Phe Asn  Ala Asn Leu Ser Ser  Lys Pro Lys Pro Asn  Ser Asn Glu 
    1115                 1120                 1125             


Asn Leu  Val Gly Ala Lys Glu  Tyr Leu Asp Pro Lys  Lys Tyr Gly 
    1130                 1135                 1140             


Gly Tyr  Ala Gly Ile Ser Asn  Ser Phe Thr Val Leu  Val Lys Gly 
    1145                 1150                 1155             


Thr Ile  Glu Lys Gly Ala Lys  Lys Lys Ile Thr Asn  Val Leu Glu 
    1160                 1165                 1170             


Phe Gln  Gly Ile Ser Ile Leu  Asp Arg Ile Asn Tyr  Arg Lys Asp 
    1175                 1180                 1185             


Lys Leu  Asn Phe Leu Leu Glu  Lys Gly Tyr Lys Asp  Ile Glu Leu 
    1190                 1195                 1200             


Ile Ile  Glu Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Ser Asp Gly 
    1205                 1210                 1215             


Ser Arg  Arg Met Leu Ala Ser  Ile Leu Ser Thr Asn  Asn Lys Arg 
    1220                 1225                 1230             


Gly Glu  Ile His Lys Gly Asn  Gln Ile Phe Leu Ser  Gln Lys Phe 
    1235                 1240                 1245             


Val Lys  Leu Leu Tyr His Ala  Lys Arg Ile Ser Asn  Thr Ile Asn 
    1250                 1255                 1260             


Glu Asn  His Arg Lys Tyr Val  Glu Asn His Lys Lys  Glu Phe Glu 
    1265                 1270                 1275             


Glu Leu  Phe Tyr Tyr Ile Leu  Glu Phe Asn Glu Asn  Tyr Val Gly 
    1280                 1285                 1290             


Ala Lys  Lys Asn Gly Lys Leu  Leu Asn Ser Ala Phe  Gln Ser Trp 
    1295                 1300                 1305             


Gln Asn  His Ser Ile Asp Glu  Leu Cys Ser Ser Phe  Ile Gly Pro 
    1310                 1315                 1320             


Thr Gly  Ser Glu Arg Lys Gly  Leu Phe Glu Leu Thr  Ser Arg Gly 
    1325                 1330                 1335             


Ser Ala  Ala Asp Phe Glu Phe  Leu Gly Val Lys Ile  Pro Arg Tyr 
    1340                 1345                 1350             


Arg Asp  Tyr Thr Pro Ser Ser  Leu Leu Lys Asp Ala  Thr Leu Ile 
    1355                 1360                 1365             


His Gln  Ser Val Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ala 
    1370                 1375                 1380             


Lys Leu  Gly Glu Gly 
    1385             


<210>  5
<211>  1334
<212>  PRT
<213>  Listeria innocua


<220>
<221>  misc_feature
<222>  (10)..(21)
<223>  N-terminal RuvC-like domain

<220>
<221>  misc_feature
<222>  (762)..(769)
<223>  RuvC-like domain

<220>
<221>  misc_feature
<222>  (840)..(866)
<223>  HNH-like domain

<220>
<221>  misc_feature
<222>  (985)..(992)
<223>  RuvC-like domain

<400>  5

Met Lys Lys Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asp Gln Tyr Asp Leu Val Lys Arg Lys Met 
            20                  25                  30          


Lys Ile Ala Gly Asp Ser Glu Lys Lys Gln Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Gln Thr Ala Ala Asp Arg Arg Met 
    50                  55                  60                  


Ala Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 
65                  70                  75                  80  


Tyr Leu Gln Gly Ile Phe Ala Glu Glu Met Ser Lys Thr Asp Ala Asn 
                85                  90                  95      


Phe Phe Cys Arg Leu Ser Asp Ser Phe Tyr Val Asp Asn Glu Lys Arg 
            100                 105                 110         


Asn Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu Val Glu Tyr 
        115                 120                 125             


His Lys Asn Tyr Pro Thr Ile Tyr His Leu Arg Glu Glu Leu Val Asn 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala Leu Asp Thr 
                165                 170                 175     


Gln Asn Thr Ser Val Asp Gly Ile Tyr Lys Gln Phe Ile Gln Thr Tyr 
            180                 185                 190         


Asn Gln Val Phe Ala Ser Gly Ile Glu Asp Gly Ser Leu Lys Lys Leu 
        195                 200                 205             


Glu Asp Asn Lys Asp Val Ala Lys Ile Leu Val Glu Lys Val Thr Arg 
    210                 215                 220                 


Lys Glu Lys Leu Glu Arg Ile Leu Lys Leu Tyr Pro Gly Glu Lys Ser 
225                 230                 235                 240 


Ala Gly Met Phe Ala Gln Phe Ile Ser Leu Ile Val Gly Ser Lys Gly 
                245                 250                 255     


Asn Phe Gln Lys Pro Phe Asp Leu Ile Glu Lys Ser Asp Ile Glu Cys 
            260                 265                 270         


Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Ser Leu Leu Ala Leu Ile 
        275                 280                 285             


Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn Ala Tyr Ser 
    290                 295                 300                 


Ala Val Val Leu Ser Ser Ile Ile Thr Val Ala Glu Thr Glu Thr Asn 
305                 310                 315                 320 


Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Thr His Glu Glu 
                325                 330                 335     


Asp Leu Gly Glu Leu Lys Ala Phe Ile Lys Leu His Leu Pro Lys His 
            340                 345                 350         


Tyr Glu Glu Ile Phe Ser Asn Thr Glu Lys His Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Asp Gly Lys Thr Lys Gln Ala Asp Phe Tyr Lys Tyr Met Lys Met 
    370                 375                 380                 


Thr Leu Glu Asn Ile Glu Gly Ala Asp Tyr Phe Ile Ala Lys Ile Glu 
385                 390                 395                 400 


Lys Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ala Ile 
                405                 410                 415     


Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Leu His Gln Gln 
            420                 425                 430         


Ala Lys Tyr Tyr Pro Phe Leu Lys Glu Asn Tyr Asp Lys Ile Lys Ser 
        435                 440                 445             


Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Asn Gly 
    450                 455                 460                 


Gln Ser Glu Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly Glu Ile Arg 
465                 470                 475                 480 


Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 
                485                 490                 495     


Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 
            500                 505                 510         


Val Leu Pro Lys His Ser Leu Cys Tyr Gln Lys Tyr Leu Val Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Val Arg Tyr Ile Asn Asp Gln Gly Lys Thr Ser Tyr 
    530                 535                 540                 


Phe Ser Gly Gln Glu Lys Glu Gln Ile Phe Asn Asp Leu Phe Lys Gln 
545                 550                 555                 560 


Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu Arg Asn Met 
                565                 570                 575     


Ser His Val Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 
            580                 585                 590         


Ser Ser Tyr Ser Thr Tyr His Asp Leu Leu Lys Val Gly Ile Lys Gln 
        595                 600                 605             


Glu Ile Leu Asp Asn Pro Val Asn Thr Glu Met Leu Glu Asn Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys Glu Gln Leu 
625                 630                 635                 640 


Gln Gln Phe Ser Asp Val Leu Asp Gly Val Val Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Met 
            660                 665                 670         


Gly Ile Arg Asp Lys Gln Ser His Leu Thr Ile Leu Asp Tyr Leu Met 
        675                 680                 685             


Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile Asn Asp Ser 
    690                 695                 700                 


Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val Thr Thr Ala 
705                 710                 715                 720 


Asp Lys Asp Ile Gln Ser Ile Val Ala Asp Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Ser Val Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Gly Lys Gly Lys Asn Asn Ser Arg Pro Arg Tyr 
    770                 775                 780                 


Lys Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Gln Glu Leu Arg Asn Asn Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Gln Asp Leu Asp 
            820                 825                 830         


Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val Pro Gln Ser 
        835                 840                 845             


Phe Ile Thr Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Ser Ser Ala 
    850                 855                 860                 


Gly Asn Arg Glu Lys Gly Asp Asp Val Pro Pro Leu Glu Ile Val Arg 
865                 870                 875                 880 


Lys Arg Lys Val Phe Trp Glu Lys Leu Tyr Gln Gly Asn Leu Met Ser 
                885                 890                 895     


Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 
            900                 905                 910         


Glu Ala Asp Lys Ala Arg Phe Ile His Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys Asn Val Ala Asn Ile Leu His Gln Arg Phe Asn Tyr 
    930                 935                 940                 


Glu Lys Asp Asp His Gly Asn Thr Met Lys Gln Val Arg Ile Val Thr 
945                 950                 955                 960 


Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe Gln Leu Tyr 
                965                 970                 975     


Lys Val Arg Asp Val Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Gly Val Val Ala Asn Thr Leu  Leu Lys Val Tyr Pro  Gln Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Asp  Tyr His Gln Phe Asp  Trp Phe Lys 
    1010                 1015                 1020             


Ala Asn  Lys Ala Thr Ala Lys  Lys Gln Phe Tyr Thr  Asn Ile Met 
    1025                 1030                 1035             


Leu Phe  Phe Ala Gln Lys Asp  Arg Ile Ile Asp Glu  Asn Gly Glu 
    1040                 1045                 1050             


Ile Leu  Trp Asp Lys Lys Tyr  Leu Asp Thr Val Lys  Lys Val Met 
    1055                 1060                 1065             


Ser Tyr  Arg Gln Met Asn Ile  Val Lys Lys Thr Glu  Ile Gln Lys 
    1070                 1075                 1080             


Gly Glu  Phe Ser Lys Ala Thr  Ile Lys Pro Lys Gly  Asn Ser Ser 
    1085                 1090                 1095             


Lys Leu  Ile Pro Arg Lys Thr  Asn Trp Asp Pro Met  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Leu  Asp Ser Pro Asn Met  Ala Tyr Ala Val Val  Ile Glu Tyr 
    1115                 1120                 1125             


Ala Lys  Gly Lys Asn Lys Leu  Val Phe Glu Lys Lys  Ile Ile Arg 
    1130                 1135                 1140             


Val Thr  Ile Met Glu Arg Lys  Ala Phe Glu Lys Asp  Glu Lys Ala 
    1145                 1150                 1155             


Phe Leu  Glu Glu Gln Gly Tyr  Arg Gln Pro Lys Val  Leu Ala Lys 
    1160                 1165                 1170             


Leu Pro  Lys Tyr Thr Leu Tyr  Glu Cys Glu Glu Gly  Arg Arg Arg 
    1175                 1180                 1185             


Met Leu  Ala Ser Ala Asn Glu  Ala Gln Lys Gly Asn  Gln Gln Val 
    1190                 1195                 1200             


Leu Pro  Asn His Leu Val Thr  Leu Leu His His Ala  Ala Asn Cys 
    1205                 1210                 1215             


Glu Val  Ser Asp Gly Lys Ser  Leu Asp Tyr Ile Glu  Ser Asn Arg 
    1220                 1225                 1230             


Glu Met  Phe Ala Glu Leu Leu  Ala His Val Ser Glu  Phe Ala Lys 
    1235                 1240                 1245             


Arg Tyr  Thr Leu Ala Glu Ala  Asn Leu Asn Lys Ile  Asn Gln Leu 
    1250                 1255                 1260             


Phe Glu  Gln Asn Lys Glu Gly  Asp Ile Lys Ala Ile  Ala Gln Ser 
    1265                 1270                 1275             


Phe Val  Asp Leu Met Ala Phe  Asn Ala Met Gly Ala  Pro Ala Ser 
    1280                 1285                 1290             


Phe Lys  Phe Phe Glu Thr Thr  Ile Glu Arg Lys Arg  Tyr Asn Asn 
    1295                 1300                 1305             


Leu Lys  Glu Leu Leu Asn Ser  Thr Ile Ile Tyr Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Ser Arg Lys  Arg Leu Asp Asp 
    1325                 1330                 


<210>  6
<211>  1053
<212>  PRT
<213>  Staphylococcus aureus

<400>  6

Met Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile 
            980                 985                 990         


Glu Val Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro Arg  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


<210>  7
<211>  3159
<212>  DNA
<213>  Staphylococcus aureus

<400>  7
atgaaaagga actacattct ggggctggac atcgggatta caagcgtggg gtatgggatt       60

attgactatg aaacaaggga cgtgatcgac gcaggcgtca gactgttcaa ggaggccaac      120

gtggaaaaca atgagggacg gagaagcaag aggggagcca ggcgcctgaa acgacggaga      180

aggcacagaa tccagagggt gaagaaactg ctgttcgatt acaacctgct gaccgaccat      240

tctgagctga gtggaattaa tccttatgaa gccagggtga aaggcctgag tcagaagctg      300

tcagaggaag agttttccgc agctctgctg cacctggcta agcgccgagg agtgcataac      360

gtcaatgagg tggaagagga caccggcaac gagctgtcta caaaggaaca gatctcacgc      420

aatagcaaag ctctggaaga gaagtatgtc gcagagctgc agctggaacg gctgaagaaa      480

gatggcgagg tgagagggtc aattaatagg ttcaagacaa gcgactacgt caaagaagcc      540

aagcagctgc tgaaagtgca gaaggcttac caccagctgg atcagagctt catcgatact      600

tatatcgacc tgctggagac tcggagaacc tactatgagg gaccaggaga agggagcccc      660

ttcggatgga aagacatcaa ggaatggtac gagatgctga tgggacattg cacctatttt      720

ccagaagagc tgagaagcgt caagtacgct tataacgcag atctgtacaa cgccctgaat      780

gacctgaaca acctggtcat caccagggat gaaaacgaga aactggaata ctatgagaag      840

ttccagatca tcgaaaacgt gtttaagcag aagaaaaagc ctacactgaa acagattgct      900

aaggagatcc tggtcaacga agaggacatc aagggctacc gggtgacaag cactggaaaa      960

ccagagttca ccaatctgaa agtgtatcac gatattaagg acatcacagc acggaaagaa     1020

atcattgaga acgccgaact gctggatcag attgctaaga tcctgactat ctaccagagc     1080

tccgaggaca tccaggaaga gctgactaac ctgaacagcg agctgaccca ggaagagatc     1140

gaacagatta gtaatctgaa ggggtacacc ggaacacaca acctgtccct gaaagctatc     1200

aatctgattc tggatgagct gtggcataca aacgacaatc agattgcaat ctttaaccgg     1260

ctgaagctgg tcccaaaaaa ggtggacctg agtcagcaga aagagatccc aaccacactg     1320

gtggacgatt tcattctgtc acccgtggtc aagcggagct tcatccagag catcaaagtg     1380

atcaacgcca tcatcaagaa gtacggcctg cccaatgata tcattatcga gctggctagg     1440

gagaagaaca gcaaggacgc acagaagatg atcaatgaga tgcagaaacg aaaccggcag     1500

accaatgaac gcattgaaga gattatccga actaccggga aagagaacgc aaagtacctg     1560

attgaaaaaa tcaagctgca cgatatgcag gagggaaagt gtctgtattc tctggaggcc     1620

atccccctgg aggacctgct gaacaatcca ttcaactacg aggtcgatca tattatcccc     1680

agaagcgtgt ccttcgacaa ttcctttaac aacaaggtgc tggtcaagca ggaagagaac     1740

tctaaaaagg gcaataggac tcctttccag tacctgtcta gttcagattc caagatctct     1800

tacgaaacct ttaaaaagca cattctgaat ctggccaaag gaaagggccg catcagcaag     1860

accaaaaagg agtacctgct ggaagagcgg gacatcaaca gattctccgt ccagaaggat     1920

tttattaacc ggaatctggt ggacacaaga tacgctactc gcggcctgat gaatctgctg     1980

cgatcctatt tccgggtgaa caatctggat gtgaaagtca agtccatcaa cggcgggttc     2040

acatcttttc tgaggcgcaa atggaagttt aaaaaggagc gcaacaaagg gtacaagcac     2100

catgccgaag atgctctgat tatcgcaaat gccgacttca tctttaagga gtggaaaaag     2160

ctggacaaag ccaagaaagt gatggagaac cagatgttcg aagagaagca ggccgaatct     2220

atgcccgaaa tcgagacaga acaggagtac aaggagattt tcatcactcc tcaccagatc     2280

aagcatatca aggatttcaa ggactacaag tactctcacc gggtggataa aaagcccaac     2340

agagagctga tcaatgacac cctgtatagt acaagaaaag acgataaggg gaataccctg     2400

attgtgaaca atctgaacgg actgtacgac aaagataatg acaagctgaa aaagctgatc     2460

aacaaaagtc ccgagaagct gctgatgtac caccatgatc ctcagacata tcagaaactg     2520

aagctgatta tggagcagta cggcgacgag aagaacccac tgtataagta ctatgaagag     2580

actgggaact acctgaccaa gtatagcaaa aaggataatg gccccgtgat caagaagatc     2640

aagtactatg ggaacaagct gaatgcccat ctggacatca cagacgatta ccctaacagt     2700

cgcaacaagg tggtcaagct gtcactgaag ccatacagat tcgatgtcta tctggacaac     2760

ggcgtgtata aatttgtgac tgtcaagaat ctggatgtca tcaaaaagga gaactactat     2820

gaagtgaata gcaagtgcta cgaagaggct aaaaagctga aaaagattag caaccaggca     2880

gagttcatcg cctcctttta caacaacgac ctgattaaga tcaatggcga actgtatagg     2940

gtcatcgggg tgaacaatga tctgctgaac cgcattgaag tgaatatgat tgacatcact     3000

taccgagagt atctggaaaa catgaatgat aagcgccccc ctcgaattat caaaacaatt     3060

gcctctaaga ctcagagtat caaaaagtac tcaaccgaca ttctgggaaa cctgtatgag     3120

gtgaagagca aaaagcaccc tcagattatc aaaaagggc                            3159


<210>  8
<211>  3159
<212>  DNA
<213>  Staphylococcus aureus

<400>  8
atgaagcgga actacatcct gggcctggac atcggcatca ccagcgtggg ctacggcatc       60

atcgactacg agacacggga cgtgatcgat gccggcgtgc ggctgttcaa agaggccaac      120

gtggaaaaca acgagggcag gcggagcaag agaggcgcca gaaggctgaa gcggcggagg      180

cggcatagaa tccagagagt gaagaagctg ctgttcgact acaacctgct gaccgaccac      240

agcgagctga gcggcatcaa cccctacgag gccagagtga agggcctgag ccagaagctg      300

agcgaggaag agttctctgc cgccctgctg cacctggcca agagaagagg cgtgcacaac      360

gtgaacgagg tggaagagga caccggcaac gagctgtcca ccaaagagca gatcagccgg      420

aacagcaagg ccctggaaga gaaatacgtg gccgaactgc agctggaacg gctgaagaaa      480

gacggcgaag tgcggggcag catcaacaga ttcaagacca gcgactacgt gaaagaagcc      540

aaacagctgc tgaaggtgca gaaggcctac caccagctgg accagagctt catcgacacc      600

tacatcgacc tgctggaaac ccggcggacc tactatgagg gacctggcga gggcagcccc      660

ttcggctgga aggacatcaa agaatggtac gagatgctga tgggccactg cacctacttc      720

cccgaggaac tgcggagcgt gaagtacgcc tacaacgccg acctgtacaa cgccctgaac      780

gacctgaaca atctcgtgat caccagggac gagaacgaga agctggaata ttacgagaag      840

ttccagatca tcgagaacgt gttcaagcag aagaagaagc ccaccctgaa gcagatcgcc      900

aaagaaatcc tcgtgaacga agaggatatt aagggctaca gagtgaccag caccggcaag      960

cccgagttca ccaacctgaa ggtgtaccac gacatcaagg acattaccgc ccggaaagag     1020

attattgaga acgccgagct gctggatcag attgccaaga tcctgaccat ctaccagagc     1080

agcgaggaca tccaggaaga actgaccaat ctgaactccg agctgaccca ggaagagatc     1140

gagcagatct ctaatctgaa gggctatacc ggcacccaca acctgagcct gaaggccatc     1200

aacctgatcc tggacgagct gtggcacacc aacgacaacc agatcgctat cttcaaccgg     1260

ctgaagctgg tgcccaagaa ggtggacctg tcccagcaga aagagatccc caccaccctg     1320

gtggacgact tcatcctgag ccccgtcgtg aagagaagct tcatccagag catcaaagtg     1380

atcaacgcca tcatcaagaa gtacggcctg cccaacgaca tcattatcga gctggcccgc     1440

gagaagaact ccaaggacgc ccagaaaatg atcaacgaga tgcagaagcg gaaccggcag     1500

accaacgagc ggatcgagga aatcatccgg accaccggca aagagaacgc caagtacctg     1560

atcgagaaga tcaagctgca cgacatgcag gaaggcaagt gcctgtacag cctggaagcc     1620

atccctctgg aagatctgct gaacaacccc ttcaactatg aggtggacca catcatcccc     1680

agaagcgtgt ccttcgacaa cagcttcaac aacaaggtgc tcgtgaagca ggaagaaaac     1740

agcaagaagg gcaaccggac cccattccag tacctgagca gcagcgacag caagatcagc     1800

tacgaaacct tcaagaagca catcctgaat ctggccaagg gcaagggcag aatcagcaag     1860

accaagaaag agtatctgct ggaagaacgg gacatcaaca ggttctccgt gcagaaagac     1920

ttcatcaacc ggaacctggt ggataccaga tacgccacca gaggcctgat gaacctgctg     1980

cggagctact tcagagtgaa caacctggac gtgaaagtga agtccatcaa tggcggcttc     2040

accagctttc tgcggcggaa gtggaagttt aagaaagagc ggaacaaggg gtacaagcac     2100

cacgccgagg acgccctgat cattgccaac gccgatttca tcttcaaaga gtggaagaaa     2160

ctggacaagg ccaaaaaagt gatggaaaac cagatgttcg aggaaaagca ggccgagagc     2220

atgcccgaga tcgaaaccga gcaggagtac aaagagatct tcatcacccc ccaccagatc     2280

aagcacatta aggacttcaa ggactacaag tacagccacc gggtggacaa gaagcctaat     2340

agagagctga ttaacgacac cctgtactcc acccggaagg acgacaaggg caacaccctg     2400

atcgtgaaca atctgaacgg cctgtacgac aaggacaatg acaagctgaa aaagctgatc     2460

aacaagagcc ccgaaaagct gctgatgtac caccacgacc cccagaccta ccagaaactg     2520

aagctgatta tggaacagta cggcgacgag aagaatcccc tgtacaagta ctacgaggaa     2580

accgggaact acctgaccaa gtactccaaa aaggacaacg gccccgtgat caagaagatt     2640

aagtattacg gcaacaaact gaacgcccat ctggacatca ccgacgacta ccccaacagc     2700

agaaacaagg tcgtgaagct gtccctgaag ccctacagat tcgacgtgta cctggacaat     2760

ggcgtgtaca agttcgtgac cgtgaagaat ctggatgtga tcaaaaaaga aaactactac     2820

gaagtgaata gcaagtgcta tgaggaagct aagaagctga agaagatcag caaccaggcc     2880

gagtttatcg cctccttcta caacaacgat ctgatcaaga tcaacggcga gctgtataga     2940

gtgatcggcg tgaacaacga cctgctgaac cggatcgaag tgaacatgat cgacatcacc     3000

taccgcgagt acctggaaaa catgaacgac aagaggcccc ccaggatcat taagacaatc     3060

gcctccaaga cccagagcat taagaagtac agcacagaca ttctgggcaa cctgtatgaa     3120

gtgaaatcta agaagcaccc tcagatcatc aaaaagggc                            3159


<210>  9
<211>  3159
<212>  DNA
<213>  Staphylococcus aureus

<400>  9
atgaagcgca actacatcct cggactggac atcggcatta cctccgtggg atacggcatc       60

atcgattacg aaactaggga tgtgatcgac gctggagtca ggctgttcaa agaggcgaac      120

gtggagaaca acgaggggcg gcgctcaaag aggggggccc gccggctgaa gcgccgccgc      180

agacatagaa tccagcgcgt gaagaagctg ctgttcgact acaaccttct gaccgaccac      240

tccgaacttt ccggcatcaa cccatatgag gctagagtga agggattgtc ccaaaagctg      300

tccgaggaag agttctccgc cgcgttgctc cacctcgcca agcgcagggg agtgcacaat      360

gtgaacgaag tggaagaaga taccggaaac gagctgtcca ccaaggagca gatcagccgg      420

aactccaagg ccctggaaga gaaatacgtg gcggaactgc aactggagcg gctgaagaaa      480

gacggagaag tgcgcggctc gatcaaccgc ttcaagacct cggactacgt gaaggaggcc      540

aagcagctcc tgaaagtgca aaaggcctat caccaacttg accagtcctt tatcgatacc      600

tacatcgatc tgctcgagac tcggcggact tactacgagg gtccagggga gggctcccca      660

tttggttgga aggatattaa ggagtggtac gaaatgctga tgggacactg cacatacttc      720

cctgaggagc tgcggagcgt gaaatacgca tacaacgcag acctgtacaa cgcgctgaac      780

gacctgaaca atctcgtgat cacccgggac gagaacgaaa agctcgagta ttacgaaaag      840

ttccagatta ttgagaacgt gttcaaacag aagaagaagc cgacactgaa gcagattgcc      900

aaggaaatcc tcgtgaacga agaggacatc aagggctatc gagtgacctc aacgggaaag      960

ccggagttca ccaatctgaa ggtctaccac gacatcaaag acattaccgc ccggaaggag     1020

atcattgaga acgcggagct gttggaccag attgcgaaga ttctgaccat ctaccaatcc     1080

tccgaggata ttcaggaaga actcaccaac ctcaacagcg aactgaccca ggaggagata     1140

gagcaaatct ccaacctgaa gggctacacc ggaactcata acctgagcct gaaggccatc     1200

aacttgatcc tggacgagct gtggcacacc aacgataacc agatcgctat tttcaatcgg     1260

ctgaagctgg tccccaagaa agtggacctc tcacaacaaa aggagatccc tactaccctt     1320

gtggacgatt tcattctgtc ccccgtggtc aagagaagct tcatacagtc aatcaaagtg     1380

atcaatgcca ttatcaagaa atacggtctg cccaacgaca ttatcattga gctcgcccgc     1440

gagaagaact cgaaggacgc ccagaagatg attaacgaaa tgcagaagag gaaccgacag     1500

actaacgaac ggatcgaaga aatcatccgg accaccggga aggaaaacgc gaagtacctg     1560

atcgaaaaga tcaagctcca tgacatgcag gaaggaaagt gtctgtactc gctggaggcc     1620

attccgctgg aggacttgct gaacaaccct tttaactacg aagtggatca tatcattccg     1680

aggagcgtgt cattcgacaa ttccttcaac aacaaggtcc tcgtgaagca ggaggaaaac     1740

tcgaagaagg gaaaccgcac gccgttccag tacctgagca gcagcgactc caagatttcc     1800

tacgaaacct tcaagaagca catcctcaac ctggcaaagg ggaagggtcg catctccaag     1860

accaagaagg aatatctgct ggaagaaaga gacatcaaca gattctccgt gcaaaaggac     1920

ttcatcaacc gcaacctcgt ggatactaga tacgctactc ggggtctgat gaacctcctg     1980

agaagctact ttagagtgaa caatctggac gtgaaggtca agtcgattaa cggaggtttc     2040

acctccttcc tgcggcgcaa gtggaagttc aagaaggaac ggaacaaggg ctacaagcac     2100

cacgccgagg acgccctgat cattgccaac gccgacttca tcttcaaaga atggaagaaa     2160

cttgacaagg ctaagaaggt catggaaaac cagatgttcg aagaaaagca ggccgagtct     2220

atgcctgaaa tcgagactga acaggagtac aaggaaatct ttattacgcc acaccagatc     2280

aaacacatca aggatttcaa ggattacaag tactcacatc gcgtggacaa aaagccgaac     2340

agggaactga tcaacgacac cctctactcc acccggaagg atgacaaagg gaataccctc     2400

atcgtcaaca accttaacgg cctgtacgac aaggacaacg ataagctgaa gaagctcatt     2460

aacaagtcgc ccgaaaagtt gctgatgtac caccacgacc ctcagactta ccagaagctc     2520

aagctgatca tggagcagta tggggacgag aaaaacccgt tgtacaagta ctacgaagaa     2580

actgggaatt atctgactaa gtactccaag aaagataacg gccccgtgat taagaagatt     2640

aagtactacg gcaacaagct gaacgcccat ctggacatca ccgatgacta ccctaattcc     2700

cgcaacaagg tcgtcaagct gagcctcaag ccctaccggt ttgatgtgta ccttgacaat     2760

ggagtgtaca agttcgtgac tgtgaagaac cttgacgtga tcaagaagga gaactactac     2820

gaagtcaact ccaagtgcta cgaggaagca aagaagttga agaagatctc gaaccaggcc     2880

gagttcattg cctccttcta taacaacgac ctgattaaga tcaacggcga actgtaccgc     2940

gtcattggcg tgaacaacga tctcctgaac cgcatcgaag tgaacatgat cgacatcact     3000

taccgggaat acctggagaa tatgaacgac aagcgcccgc cccggatcat taagactatc     3060

gcctcaaaga cccagtcgat caagaagtac agcaccgaca tcctgggcaa cctgtacgag     3120

gtcaaatcga agaagcaccc ccagatcatc aagaaggga                            3159


<210>  10
<211>  3159
<212>  DNA
<213>  Staphylococcus aureus

<400>  10
atgaaaagga actacattct ggggctggcc atcgggatta caagcgtggg gtatgggatt       60

attgactatg aaacaaggga cgtgatcgac gcaggcgtca gactgttcaa ggaggccaac      120

gtggaaaaca atgagggacg gagaagcaag aggggagcca ggcgcctgaa acgacggaga      180

aggcacagaa tccagagggt gaagaaactg ctgttcgatt acaacctgct gaccgaccat      240

tctgagctga gtggaattaa tccttatgaa gccagggtga aaggcctgag tcagaagctg      300

tcagaggaag agttttccgc agctctgctg cacctggcta agcgccgagg agtgcataac      360

gtcaatgagg tggaagagga caccggcaac gagctgtcta caaaggaaca gatctcacgc      420

aatagcaaag ctctggaaga gaagtatgtc gcagagctgc agctggaacg gctgaagaaa      480

gatggcgagg tgagagggtc aattaatagg ttcaagacaa gcgactacgt caaagaagcc      540

aagcagctgc tgaaagtgca gaaggcttac caccagctgg atcagagctt catcgatact      600

tatatcgacc tgctggagac tcggagaacc tactatgagg gaccaggaga agggagcccc      660

ttcggatgga aagacatcaa ggaatggtac gagatgctga tgggacattg cacctatttt      720

ccagaagagc tgagaagcgt caagtacgct tataacgcag atctgtacaa cgccctgaat      780

gacctgaaca acctggtcat caccagggat gaaaacgaga aactggaata ctatgagaag      840

ttccagatca tcgaaaacgt gtttaagcag aagaaaaagc ctacactgaa acagattgct      900

aaggagatcc tggtcaacga agaggacatc aagggctacc gggtgacaag cactggaaaa      960

ccagagttca ccaatctgaa agtgtatcac gatattaagg acatcacagc acggaaagaa     1020

atcattgaga acgccgaact gctggatcag attgctaaga tcctgactat ctaccagagc     1080

tccgaggaca tccaggaaga gctgactaac ctgaacagcg agctgaccca ggaagagatc     1140

gaacagatta gtaatctgaa ggggtacacc ggaacacaca acctgtccct gaaagctatc     1200

aatctgattc tggatgagct gtggcataca aacgacaatc agattgcaat ctttaaccgg     1260

ctgaagctgg tcccaaaaaa ggtggacctg agtcagcaga aagagatccc aaccacactg     1320

gtggacgatt tcattctgtc acccgtggtc aagcggagct tcatccagag catcaaagtg     1380

atcaacgcca tcatcaagaa gtacggcctg cccaatgata tcattatcga gctggctagg     1440

gagaagaaca gcaaggacgc acagaagatg atcaatgaga tgcagaaacg aaaccggcag     1500

accaatgaac gcattgaaga gattatccga actaccggga aagagaacgc aaagtacctg     1560

attgaaaaaa tcaagctgca cgatatgcag gagggaaagt gtctgtattc tctggaggcc     1620

atccccctgg aggacctgct gaacaatcca ttcaactacg aggtcgatca tattatcccc     1680

agaagcgtgt ccttcgacaa ttcctttaac aacaaggtgc tggtcaagca ggaagagaac     1740

tctaaaaagg gcaataggac tcctttccag tacctgtcta gttcagattc caagatctct     1800

tacgaaacct ttaaaaagca cattctgaat ctggccaaag gaaagggccg catcagcaag     1860

accaaaaagg agtacctgct ggaagagcgg gacatcaaca gattctccgt ccagaaggat     1920

tttattaacc ggaatctggt ggacacaaga tacgctactc gcggcctgat gaatctgctg     1980

cgatcctatt tccgggtgaa caatctggat gtgaaagtca agtccatcaa cggcgggttc     2040

acatcttttc tgaggcgcaa atggaagttt aaaaaggagc gcaacaaagg gtacaagcac     2100

catgccgaag atgctctgat tatcgcaaat gccgacttca tctttaagga gtggaaaaag     2160

ctggacaaag ccaagaaagt gatggagaac cagatgttcg aagagaagca ggccgaatct     2220

atgcccgaaa tcgagacaga acaggagtac aaggagattt tcatcactcc tcaccagatc     2280

aagcatatca aggatttcaa ggactacaag tactctcacc gggtggataa aaagcccaac     2340

agagagctga tcaatgacac cctgtatagt acaagaaaag acgataaggg gaataccctg     2400

attgtgaaca atctgaacgg actgtacgac aaagataatg acaagctgaa aaagctgatc     2460

aacaaaagtc ccgagaagct gctgatgtac caccatgatc ctcagacata tcagaaactg     2520

aagctgatta tggagcagta cggcgacgag aagaacccac tgtataagta ctatgaagag     2580

actgggaact acctgaccaa gtatagcaaa aaggataatg gccccgtgat caagaagatc     2640

aagtactatg ggaacaagct gaatgcccat ctggacatca cagacgatta ccctaacagt     2700

cgcaacaagg tggtcaagct gtcactgaag ccatacagat tcgatgtcta tctggacaac     2760

ggcgtgtata aatttgtgac tgtcaagaat ctggatgtca tcaaaaagga gaactactat     2820

gaagtgaata gcaagtgcta cgaagaggct aaaaagctga aaaagattag caaccaggca     2880

gagttcatcg cctcctttta caacaacgac ctgattaaga tcaatggcga actgtatagg     2940

gtcatcgggg tgaacaatga tctgctgaac cgcattgaag tgaatatgat tgacatcact     3000

taccgagagt atctggaaaa catgaatgat aagcgccccc ctcgaattat caaaacaatt     3060

gcctctaaga ctcagagtat caaaaagtac tcaaccgaca ttctgggaaa cctgtatgag     3120

gtgaagagca aaaagcaccc tcagattatc aaaaagggc                            3159


<210>  11
<211>  3159
<212>  DNA
<213>  Staphylococcus aureus

<400>  11
atgaaaagga actacattct ggggctggac atcgggatta caagcgtggg gtatgggatt       60

attgactatg aaacaaggga cgtgatcgac gcaggcgtca gactgttcaa ggaggccaac      120

gtggaaaaca atgagggacg gagaagcaag aggggagcca ggcgcctgaa acgacggaga      180

aggcacagaa tccagagggt gaagaaactg ctgttcgatt acaacctgct gaccgaccat      240

tctgagctga gtggaattaa tccttatgaa gccagggtga aaggcctgag tcagaagctg      300

tcagaggaag agttttccgc agctctgctg cacctggcta agcgccgagg agtgcataac      360

gtcaatgagg tggaagagga caccggcaac gagctgtcta caaaggaaca gatctcacgc      420

aatagcaaag ctctggaaga gaagtatgtc gcagagctgc agctggaacg gctgaagaaa      480

gatggcgagg tgagagggtc aattaatagg ttcaagacaa gcgactacgt caaagaagcc      540

aagcagctgc tgaaagtgca gaaggcttac caccagctgg atcagagctt catcgatact      600

tatatcgacc tgctggagac tcggagaacc tactatgagg gaccaggaga agggagcccc      660

ttcggatgga aagacatcaa ggaatggtac gagatgctga tgggacattg cacctatttt      720

ccagaagagc tgagaagcgt caagtacgct tataacgcag atctgtacaa cgccctgaat      780

gacctgaaca acctggtcat caccagggat gaaaacgaga aactggaata ctatgagaag      840

ttccagatca tcgaaaacgt gtttaagcag aagaaaaagc ctacactgaa acagattgct      900

aaggagatcc tggtcaacga agaggacatc aagggctacc gggtgacaag cactggaaaa      960

ccagagttca ccaatctgaa agtgtatcac gatattaagg acatcacagc acggaaagaa     1020

atcattgaga acgccgaact gctggatcag attgctaaga tcctgactat ctaccagagc     1080

tccgaggaca tccaggaaga gctgactaac ctgaacagcg agctgaccca ggaagagatc     1140

gaacagatta gtaatctgaa ggggtacacc ggaacacaca acctgtccct gaaagctatc     1200

aatctgattc tggatgagct gtggcataca aacgacaatc agattgcaat ctttaaccgg     1260

ctgaagctgg tcccaaaaaa ggtggacctg agtcagcaga aagagatccc aaccacactg     1320

gtggacgatt tcattctgtc acccgtggtc aagcggagct tcatccagag catcaaagtg     1380

atcaacgcca tcatcaagaa gtacggcctg cccaatgata tcattatcga gctggctagg     1440

gagaagaaca gcaaggacgc acagaagatg atcaatgaga tgcagaaacg aaaccggcag     1500

accaatgaac gcattgaaga gattatccga actaccggga aagagaacgc aaagtacctg     1560

attgaaaaaa tcaagctgca cgatatgcag gagggaaagt gtctgtattc tctggaggcc     1620

atccccctgg aggacctgct gaacaatcca ttcaactacg aggtcgatca tattatcccc     1680

agaagcgtgt ccttcgacaa ttcctttaac aacaaggtgc tggtcaagca ggaagaggcc     1740

tctaaaaagg gcaataggac tcctttccag tacctgtcta gttcagattc caagatctct     1800

tacgaaacct ttaaaaagca cattctgaat ctggccaaag gaaagggccg catcagcaag     1860

accaaaaagg agtacctgct ggaagagcgg gacatcaaca gattctccgt ccagaaggat     1920

tttattaacc ggaatctggt ggacacaaga tacgctactc gcggcctgat gaatctgctg     1980

cgatcctatt tccgggtgaa caatctggat gtgaaagtca agtccatcaa cggcgggttc     2040

acatcttttc tgaggcgcaa atggaagttt aaaaaggagc gcaacaaagg gtacaagcac     2100

catgccgaag atgctctgat tatcgcaaat gccgacttca tctttaagga gtggaaaaag     2160

ctggacaaag ccaagaaagt gatggagaac cagatgttcg aagagaagca ggccgaatct     2220

atgcccgaaa tcgagacaga acaggagtac aaggagattt tcatcactcc tcaccagatc     2280

aagcatatca aggatttcaa ggactacaag tactctcacc gggtggataa aaagcccaac     2340

agagagctga tcaatgacac cctgtatagt acaagaaaag acgataaggg gaataccctg     2400

attgtgaaca atctgaacgg actgtacgac aaagataatg acaagctgaa aaagctgatc     2460

aacaaaagtc ccgagaagct gctgatgtac caccatgatc ctcagacata tcagaaactg     2520

aagctgatta tggagcagta cggcgacgag aagaacccac tgtataagta ctatgaagag     2580

actgggaact acctgaccaa gtatagcaaa aaggataatg gccccgtgat caagaagatc     2640

aagtactatg ggaacaagct gaatgcccat ctggacatca cagacgatta ccctaacagt     2700

cgcaacaagg tggtcaagct gtcactgaag ccatacagat tcgatgtcta tctggacaac     2760

ggcgtgtata aatttgtgac tgtcaagaat ctggatgtca tcaaaaagga gaactactat     2820

gaagtgaata gcaagtgcta cgaagaggct aaaaagctga aaaagattag caaccaggca     2880

gagttcatcg cctcctttta caacaacgac ctgattaaga tcaatggcga actgtatagg     2940

gtcatcgggg tgaacaatga tctgctgaac cgcattgaag tgaatatgat tgacatcact     3000

taccgagagt atctggaaaa catgaatgat aagcgccccc ctcgaattat caaaacaatt     3060

gcctctaaga ctcagagtat caaaaagtac tcaaccgaca ttctgggaaa cctgtatgag     3120

gtgaagagca aaaagcaccc tcagattatc aaaaagggc                            3159


<210>  12
<211>  1082
<212>  PRT
<213>  Neisseria meningitidis

<400>  12

Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Asp 
            20                  25                  30          


Glu Asn Pro Ile Cys Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210>  13
<211>  3249
<212>  DNA
<213>  Neisseria meningitidis


<220>
<221>  misc_feature
<222>  (1)..(3249)
<223>  Exemplary codon optimized Cas9

<400>  13
atggccgcct tcaagcccaa ccccatcaac tacatcctgg gcctggacat cggcatcgcc       60

agcgtgggct gggccatggt ggagatcgac gaggacgaga accccatctg cctgatcgac      120

ctgggtgtgc gcgtgttcga gcgcgctgag gtgcccaaga ctggtgacag tctggctatg      180

gctcgccggc ttgctcgctc tgttcggcgc cttactcgcc ggcgcgctca ccgccttctg      240

cgcgctcgcc gcctgctgaa gcgcgagggt gtgctgcagg ctgccgactt cgacgagaac      300

ggcctgatca agagcctgcc caacactcct tggcagctgc gcgctgccgc tctggaccgc      360

aagctgactc ctctggagtg gagcgccgtg ctgctgcacc tgatcaagca ccgcggctac      420

ctgagccagc gcaagaacga gggcgagacc gccgacaagg agctgggtgc tctgctgaag      480

ggcgtggccg acaacgccca cgccctgcag actggtgact tccgcactcc tgctgagctg      540

gccctgaaca agttcgagaa ggagagcggc cacatccgca accagcgcgg cgactacagc      600

cacaccttca gccgcaagga cctgcaggcc gagctgatcc tgctgttcga gaagcagaag      660

gagttcggca acccccacgt gagcggcggc ctgaaggagg gcatcgagac cctgctgatg      720

acccagcgcc ccgccctgag cggcgacgcc gtgcagaaga tgctgggcca ctgcaccttc      780

gagccagccg agcccaaggc cgccaagaac acctacaccg ccgagcgctt catctggctg      840

accaagctga acaacctgcg catcctggag cagggcagcg agcgccccct gaccgacacc      900

gagcgcgcca ccctgatgga cgagccctac cgcaagagca agctgaccta cgcccaggcc      960

cgcaagctgc tgggtctgga ggacaccgcc ttcttcaagg gcctgcgcta cggcaaggac     1020

aacgccgagg ccagcaccct gatggagatg aaggcctacc acgccatcag ccgcgccctg     1080

gagaaggagg gcctgaagga caagaagagt cctctgaacc tgagccccga gctgcaggac     1140

gagatcggca ccgccttcag cctgttcaag accgacgagg acatcaccgg ccgcctgaag     1200

gaccgcatcc agcccgagat cctggaggcc ctgctgaagc acatcagctt cgacaagttc     1260

gtgcagatca gcctgaaggc cctgcgccgc atcgtgcccc tgatggagca gggcaagcgc     1320

tacgacgagg cctgcgccga gatctacggc gaccactacg gcaagaagaa caccgaggag     1380

aagatctacc tgcctcctat ccccgccgac gagatccgca accccgtggt gctgcgcgcc     1440

ctgagccagg cccgcaaggt gatcaacggc gtggtgcgcc gctacggcag ccccgcccgc     1500

atccacatcg agaccgcccg cgaggtgggc aagagcttca aggaccgcaa ggagatcgag     1560

aagcgccagg aggagaaccg caaggaccgc gagaaggccg ccgccaagtt ccgcgagtac     1620

ttccccaact tcgtgggcga gcccaagagc aaggacatcc tgaagctgcg cctgtacgag     1680

cagcagcacg gcaagtgcct gtacagcggc aaggagatca acctgggccg cctgaacgag     1740

aagggctacg tggagatcga ccacgccctg cccttcagcc gcacctggga cgacagcttc     1800

aacaacaagg tgctggtgct gggcagcgag aaccagaaca agggcaacca gaccccctac     1860

gagtacttca acggcaagga caacagccgc gagtggcagg agttcaaggc ccgcgtggag     1920

accagccgct tcccccgcag caagaagcag cgcatcctgc tgcagaagtt cgacgaggac     1980

ggcttcaagg agcgcaacct gaacgacacc cgctacgtga accgcttcct gtgccagttc     2040

gtggccgacc gcatgcgcct gaccggcaag ggcaagaagc gcgtgttcgc cagcaacggc     2100

cagatcacca acctgctgcg cggcttctgg ggcctgcgca aggtgcgcgc cgagaacgac     2160

cgccaccacg ccctggacgc cgtggtggtg gcctgcagca ccgtggccat gcagcagaag     2220

atcacccgct tcgtgcgcta caaggagatg aacgccttcg acggtaaaac catcgacaag     2280

gagaccggcg aggtgctgca ccagaagacc cacttccccc agccctggga gttcttcgcc     2340

caggaggtga tgatccgcgt gttcggcaag cccgacggca agcccgagtt cgaggaggcc     2400

gacacccccg agaagctgcg caccctgctg gccgagaagc tgagcagccg ccctgaggcc     2460

gtgcacgagt acgtgactcc tctgttcgtg agccgcgccc ccaaccgcaa gatgagcggt     2520

cagggtcaca tggagaccgt gaagagcgcc aagcgcctgg acgagggcgt gagcgtgctg     2580

cgcgtgcccc tgacccagct gaagctgaag gacctggaga agatggtgaa ccgcgagcgc     2640

gagcccaagc tgtacgaggc cctgaaggcc cgcctggagg cccacaagga cgaccccgcc     2700

aaggccttcg ccgagccctt ctacaagtac gacaaggccg gcaaccgcac ccagcaggtg     2760

aaggccgtgc gcgtggagca ggtgcagaag accggcgtgt gggtgcgcaa ccacaacggc     2820

atcgccgaca acgccaccat ggtgcgcgtg gacgtgttcg agaagggcga caagtactac     2880

ctggtgccca tctacagctg gcaggtggcc aagggcatcc tgcccgaccg cgccgtggtg     2940

cagggcaagg acgaggagga ctggcagctg atcgacgaca gcttcaactt caagttcagc     3000

ctgcacccca acgacctggt ggaggtgatc accaagaagg cccgcatgtt cggctacttc     3060

gccagctgcc accgcggcac cggcaacatc aacatccgca tccacgacct ggaccacaag     3120

atcggcaaga acggcatcct ggagggcatc ggcgtgaaga ccgccctgag cttccagaag     3180

taccagatcg acgagctggg caaggagatc cgcccctgcc gcctgaagaa gcgccctcct     3240

gtgcgctaa                                                             3249


<210>  14
<211>  859
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Cas9 consensus sequence derived from Sm, Sp, St, and Li
       Cas9 sequences


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(18)
<223>  N-terminal RuvC-like domain

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(31)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (71)..(71)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (78)..(80)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (89)..(89)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (90)..(90)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (98)..(98)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (113)..(113)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (116)..(116)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (125)..(125)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (126)..(126)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (128)..(133)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (135)..(135)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (137)..(137)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (139)..(147)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (153)..(155)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (157)..(157)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (159)..(159)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (161)..(161)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (163)..(163)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (166)..(168)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (170)..(170)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (171)..(171)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (173)..(175)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (177)..(177)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (183)..(183)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (185)..(187)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (189)..(189)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (192)..(195)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (198)..(198)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (199)..(199)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (202)..(202)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (206)..(206)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (207)..(207)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (210)..(210)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (212)..(212)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (213)..(213)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (219)..(219)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (220)..(220)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (222)..(222)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (224)..(224)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (226)..(226)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (236)..(236)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (240)..(240)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (241)..(241)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (244)..(246)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (248)..(248)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (249)..(249)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (250)..(250)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (252)..(254)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (256)..(256)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (257)..(257)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (268)..(268)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (271)..(271)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (273)..(273)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (277)..(277)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (280)..(280)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (281)..(281)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (283)..(283)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (289)..(289)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (290)..(290)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (292)..(294)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (301)..(301)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (308)..(308)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (319)..(322)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (328)..(328)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (329)..(329)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (335)..(337)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (346)..(346)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (347)..(347)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (356)..(361)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (363)..(363)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (370)..(373)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (375)..(375)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (376)..(376)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (379)..(379)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (386)..(390)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (393)..(393)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (395)..(395)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (396)..(396)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (398)..(398)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (400)..(400)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (403)..(403)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (407)..(407)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (410)..(410)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (411)..(411)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (413)..(416)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (418)..(418)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (422)..(422)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (428)..(428)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (431)..(431)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (433)..(433)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (437)..(439)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (445)..(445)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (451)..(451)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (456)..(456)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (459)..(459)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (465)..(469)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (481)..(481)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (482)..(482)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (484)..(484)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (490)..(490)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (494)..(494)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (495)..(502)
<223>  RuvC-like domain

<220>
<221>  misc_feature
<222>  (497)..(497)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (506)..(506)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (510)..(510)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (513)..(513)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (514)..(514)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (517)..(517)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (520)..(520)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (525)..(525)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (526)..(526)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (529)..(529)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (531)..(531)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (532)..(532)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (534)..(534)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (542)..(542)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (546)..(546)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (547)..(547)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (553)..(553)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (555)..(575)
<223>  HNH-like domain

<220>
<221>  misc_feature
<222>  (556)..(556)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (560)..(560)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (563)..(563)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (565)..(565)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (567)..(567)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (579)..(579)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (582)..(582)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (583)..(583)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (585)..(585)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (588)..(588)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (590)..(590)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (592)..(592)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (594)..(596)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (610)..(610)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (616)..(616)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (628)..(628)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (631)..(631)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (633)..(633)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (634)..(634)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (636)..(636)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (638)..(641)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (643)..(645)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (653)..(653)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (657)..(657)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (659)..(659)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (660)..(660)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (665)..(665)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (666)..(666)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (668)..(668)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (669)..(669)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (670)..(677)
<223>  RuvC-like domain

<220>
<221>  misc_feature
<222>  (680)..(680)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (681)..(681)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (683)..(683)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (686)..(686)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (696)..(696)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (697)..(697)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (704)..(704)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (708)..(708)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (710)..(710)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (711)..(711)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (714)..(714)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (717)..(720)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (722)..(722)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (725)..(725)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (727)..(727)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (733)..(735)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (740)..(740)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (742)..(742)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (749)..(754)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (758)..(761)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (763)..(768)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (771)..(771)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (774)..(777)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (782)..(782)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (784)..(786)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (788)..(788)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (790)..(790)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (795)..(795)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (799)..(799)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (801)..(801)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (802)..(802)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (804)..(804)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (806)..(813)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (815)..(818)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (820)..(820)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (823)..(827)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (829)..(829)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (830)..(830)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (832)..(832)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (835)..(837)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (842)..(844)
<223>  Each Xaa can independently be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (846)..(846)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (848)..(848)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (851)..(851)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (857)..(857)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (857)..(857)
<223>  Xaa can be any naturally occurring amino acid

<400>  14

Met Lys Tyr Xaa Ile Gly Leu Asp Ile Gly Thr Asn Ser Val Gly Trp 
1               5                   10                  15      


Ala Val Thr Asp Xaa Tyr Xaa Xaa Lys Xaa Lys Gly Xaa Xaa Xaa Ile 
            20                  25                  30          


Xaa Lys Asn Xaa Gly Leu Phe Asp Gly Thr Ala Arg Xaa Arg Thr Ala 
        35                  40                  45              


Arg Arg Arg Arg Arg Xaa Asn Arg Ile Tyr Leu Gln Ile Phe Xaa Glu 
    50                  55                  60                  


Met Asp Phe Phe Arg Leu Xaa Ser Phe Val Xaa Xaa Lys Xaa Xaa Xaa 
65                  70                  75                  80  


Pro Xaa Phe Xaa Xaa Glu Tyr His Xaa Xaa Pro Thr Ile Tyr His Leu 
                85                  90                  95      


Arg Xaa Leu Xaa Lys Asp Leu Arg Leu Xaa Tyr Leu Ala Leu Ala His 
            100                 105                 110         


Xaa Ile Lys Xaa Arg Gly Asn Phe Leu Ile Glu Gly Xaa Xaa Asn Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Tyr Xaa Phe Xaa Ile Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Pro Glu Lys Gly Phe Xaa Xaa Xaa Leu Xaa Gly Xaa Phe 
145                 150                 155                 160 


Xaa Phe Xaa Leu Glu Xaa Xaa Xaa Lys Xaa Xaa Tyr Xaa Xaa Xaa Leu 
                165                 170                 175     


Xaa Leu Leu Ile Gly Asp Xaa Tyr Xaa Xaa Xaa Phe Xaa Ala Lys Xaa 
            180                 185                 190         


Xaa Xaa Xaa Leu Ser Xaa Xaa Val Thr Xaa Ala Leu Ser Xaa Xaa Met 
        195                 200                 205             


Ile Xaa Arg Xaa Xaa His Asp Leu Leu Lys Xaa Xaa Tyr Xaa Glu Xaa 
    210                 215                 220                 


Phe Xaa Lys Gly Tyr Ala Gly Tyr Ile Asp Gly Xaa Gln Phe Tyr Xaa 
225                 230                 235                 240 


Xaa Lys Leu Xaa Xaa Xaa Gly Xaa Xaa Xaa Lys Xaa Xaa Xaa Glu Xaa 
                245                 250                 255     


Xaa Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Xaa Ile Pro Xaa Gln 
            260                 265                 270         


Xaa His Leu Glu Xaa Ala Ile Xaa Xaa Gln Xaa Tyr Pro Phe Leu Asn 
        275                 280                 285             


Xaa Xaa Ile Xaa Xaa Xaa Thr Phe Arg Ile Pro Tyr Xaa Val Gly Pro 
    290                 295                 300                 


Leu Ala Gly Xaa Ser Phe Ala Trp Arg Lys Ile Pro Trp Asn Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Asp Ser Ala Phe Ile Xaa Xaa Met Thr Asp Leu Pro Xaa Xaa 
                325                 330                 335     


Xaa Val Leu Pro Lys His Ser Leu Tyr Xaa Xaa Val Tyr Asn Glu Leu 
            340                 345                 350         


Thr Lys Val Xaa Xaa Xaa Xaa Xaa Xaa Lys Xaa Ile Phe Lys Arg Lys 
        355                 360                 365             


Val Xaa Xaa Xaa Xaa Gly Xaa Xaa Phe Asn Xaa Ser Thr Tyr His Asp 
    370                 375                 380                 


Leu Xaa Xaa Xaa Xaa Xaa Leu Asp Xaa Asn Xaa Xaa Glu Xaa Ile Xaa 
385                 390                 395                 400 


Leu Thr Xaa Phe Glu Asp Xaa Met Ile Xaa Xaa Leu Xaa Xaa Xaa Xaa 
                405                 410                 415     


Lys Xaa Leu Arg Arg Xaa Tyr Thr Gly Trp Gly Xaa Leu Ser Xaa Leu 
            420                 425                 430         


Xaa Gly Ile Arg Xaa Xaa Xaa Ser Thr Ile Leu Asp Xaa Leu Asp Asn 
        435                 440                 445             


Arg Asn Xaa Met Gln Leu Ile Xaa Asp Leu Xaa Phe Lys Ile Lys Gln 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Xaa Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln 
465                 470                 475                 480 


Xaa Xaa Lys Xaa Val Asp Glu Leu Val Xaa Met Gly Pro Xaa Ile Val 
                485                 490                 495     


Xaa Glu Met Ala Arg Glu Asn Gln Thr Xaa Gly Asn Ser Xaa Arg Lys 
            500                 505                 510         


Xaa Xaa Lys Glu Xaa Gly Ser Xaa Ile Leu Lys Glu Xaa Xaa Asn Leu 
        515                 520                 525             


Xaa Asn Xaa Xaa Leu Xaa Leu Tyr Tyr Leu Gln Asn Gly Xaa Asp Met 
    530                 535                 540                 


Tyr Xaa Xaa Leu Asp Ile Leu Ser Xaa Tyr Asp Xaa Asp His Ile Xaa 
545                 550                 555                 560 


Pro Gln Xaa Phe Xaa Asp Xaa Ser Ile Asp Asn Val Leu Ser Asn Arg 
                565                 570                 575     


Lys Asp Xaa Val Pro Xaa Xaa Val Xaa Lys Lys Xaa Trp Xaa Leu Xaa 
            580                 585                 590         


Leu Xaa Xaa Xaa Arg Lys Phe Asp Leu Thr Lys Ala Glu Arg Gly Gly 
        595                 600                 605             


Leu Xaa Asp Lys Ala Phe Ile Xaa Arg Gln Leu Val Glu Thr Arg Gln 
    610                 615                 620                 


Ile Thr Lys Xaa Val Ala Xaa Leu Xaa Xaa Asn Xaa Asp Xaa Xaa Xaa 
625                 630                 635                 640 


Xaa Val Xaa Xaa Xaa Thr Leu Lys Ser Leu Val Ser Xaa Phe Arg Lys 
                645                 650                 655     


Xaa Phe Xaa Xaa Leu Tyr Lys Val Xaa Xaa Asn Xaa Xaa His His Ala 
            660                 665                 670         


His Asp Ala Tyr Leu Asn Val Xaa Xaa Leu Xaa Tyr Pro Xaa Leu Glu 
        675                 680                 685             


Glu Phe Val Tyr Gly Asp Tyr Xaa Xaa Lys Ala Thr Lys Phe Tyr Xaa 
    690                 695                 700                 


Asn Ile Met Xaa Phe Xaa Xaa Gly Glu Xaa Trp Lys Xaa Xaa Xaa Xaa 
705                 710                 715                 720 


Val Xaa Met Gln Xaa Asn Xaa Val Lys Lys Glu Gln Xaa Xaa Xaa Pro 
                725                 730                 735     


Lys Asn Ser Xaa Leu Xaa Lys Asp Lys Tyr Gly Gly Xaa Xaa Xaa Xaa 
            740                 745                 750         


Xaa Xaa Lys Gly Lys Xaa Xaa Xaa Xaa Ile Xaa Xaa Xaa Xaa Xaa Xaa 
        755                 760                 765             


Phe Leu Xaa Gly Tyr Xaa Xaa Xaa Xaa Leu Pro Lys Tyr Xaa Leu Xaa 
    770                 775                 780                 


Xaa Xaa Gly Xaa Arg Xaa Leu Ala Ser Glu Xaa Lys Gly Asn Xaa Leu 
785                 790                 795                 800 


Xaa Xaa Leu Xaa Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu Xaa Xaa 
                805                 810                 815     


Xaa Xaa Phe Xaa Ala Asn Xaa Xaa Xaa Xaa Xaa Leu Xaa Xaa Gly Xaa 
            820                 825                 830         


Ala Phe Xaa Xaa Xaa Ile Arg Arg Tyr Xaa Xaa Xaa Thr Xaa Ile Xaa 
        835                 840                 845             


Gln Ser Xaa Thr Gly Leu Tyr Glu Xaa Arg Leu 
    850                 855                 


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RuvC-like domain


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is Val or His

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is Ile, Leu, or Val

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa is Met or Thr

<400>  15

Ile Xaa Xaa Glu Xaa Ala Arg Glu 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RuvC-like domain


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is Ile, Leu, or Val

<400>  16

Ile Val Xaa Glu Met Ala Arg Glu 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RuvC-like domain


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa is His or Leu

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa is Arg or Val

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa is Glu or Val

<400>  17

His His Ala Xaa Asp Ala Xaa Xaa 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RuvC-like domain

<400>  18

His His Ala His Asp Ala Tyr Leu 
1               5               


<210>  19
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal RuvC-like domain


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is Lys or Pro

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa is Val, Leu, Ile, or Phe

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa is Gly, Ala, or Ser

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa is Leu, Ile, Val, or Phe

<220>
<221>  MOD_RES
<222>  (7)..(26)
<223>  N-terminal RuvC-like domain, each Xaa can be any amino acid or 
       absent, region may encompass 5-20 residues

<220>
<221>  VARIANT
<222>  (29)..(29)
<223>  Xaa is Asp, Glu, Asn, or Gln

<400>  19

Lys Xaa Tyr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Thr Asp Xaa Tyr 
            20                  25                  30  


<210>  20
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal RuvC-like domain


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is Ile, Val, Met, Leu, or Thr

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa is Thr, Ile, Val, Ser, Asn, Tyr, Glu, or Leu

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa is Asn, Ser, Gly, Ala, Asp, Thr, Arg, Met, or Phe

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa is Ser, Tyr, Asn, or Phe

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa is Val, Ile, Leu, Cys, Thr, or Phe

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa is Trp, Phe, Val, Tyr, Ser, or Leu

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa is Ala, Ser, Cys, Val, or Gly

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Xaa is Val, Ile, Leu, Ala, Met, or His

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Any amino acid or absent

<400>  20

Asp Xaa Gly Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa 
1               5                   10          


<210>  21
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal RuvC-like domain


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is Ile, Val, Met, Leu, or Thr

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa is Thr, Ile, Val, Ser, Asn, Tyr, Glu, or Leu

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa is Asn, Ser, Gly, Ala, Asp, Thr, Arg, Met, or Phe

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa is Val, Ile, Leu, Cys, Thr, or Phe

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa is Trp, Phe, Val, Tyr, Ser, or Leu

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa is Ala, Ser, Cys, Val, or Gly

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Xaa is Val, Ile, Leu, Ala, Met, or His

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Any amino acid or absent

<400>  21

Asp Xaa Gly Xaa Xaa Ser Xaa Gly Xaa Xaa Xaa Xaa 
1               5                   10          


<210>  22
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal RuvC-like domain


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa is Thr, Ile, Val, Ser, Asn, Tyr, Glu, or Leu

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa is Asn, Ser, Gly, Ala, Asp, Thr, Arg, Met, or Phe

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Xaa is Val, Ile, Leu, Ala, Met, or His

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Any amino acid or absent

<400>  22

Asp Ile Gly Xaa Xaa Ser Val Gly Trp Ala Xaa Xaa 
1               5                   10          


<210>  23
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal RuvC-like domain


<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Any non-polar alkyl amino acid or a hydroxyl amino acid

<400>  23

Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Xaa 
1               5                   10          


<210>  24
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HNH-like domain


<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa is Lys or Arg

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Xaa is Val or Thr

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  Xaa is Gly or Asp

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  Xaa is Glu, Gln, or Asp

<220>
<221>  VARIANT
<222>  (15)..(15)
<223>  Xaa is Glu or Asp

<220>
<221>  VARIANT
<222>  (19)..(19)
<223>  Xaa is Asp, Asn, or His

<220>
<221>  VARIANT
<222>  (20)..(20)
<223>  Xaa is Tyr, Arg, or Asn

<220>
<221>  VARIANT
<222>  (23)..(23)
<223>  Xaa is Gln, Asp, or Asn

<220>
<221>  MOD_RES
<222>  (25)..(64)
<223>  HNH-like domain, each Xaa can be any amino acid or absent, region
       may encompass 15-40 residues

<220>
<221>  VARIANT
<222>  (67)..(67)
<223>  Xaa is Gly or Glu

<220>
<221>  VARIANT
<222>  (69)..(69)
<223>  Xaa is Ser or Gly

<220>
<221>  VARIANT
<222>  (71)..(71)
<223>  Xaa is Asp or Asn

<400>  24

Leu Tyr Tyr Leu Gln Asn Gly Xaa Asp Met Tyr Xaa Xaa Xaa Xaa Leu 
1               5                   10                  15      


Asp Ile Xaa Xaa Leu Ser Xaa Tyr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Asn Arg Xaa Lys Xaa Asp Xaa Val Pro 
65                  70              


<210>  25
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HNH-like domain


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Asp, Glu, Gln, or Asn

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is Leu, Ile, Arg, Gln, Val, Met, or Lys

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is Asp or Glu

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa is Ile, Val, Thr, Ala, or Leu

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa is Val, Tyr, Ile, Leu, Phe, or Trp

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa is Gln, His, Arg, Lys, Tyr, Ile, Leu, Phe, or Trp

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa is Ser, Ala, Asp, Thr, or Lys

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa is Phe, Leu, Val, Lys, Tyr, Met, Ile, Arg, Ala, Glu, Asp, or 
       Gln

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Xaa is Leu, Arg, Thr, Ile, Val, Ser, Cys, Tyr, Lys, Phe, or Gly

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Xaa is Lys, Gln, Tyr, Thr, Phe, Leu, Trp, Met, Ala, Glu, Gly, or 
       Ser

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  Xaa is Asp, Ser, Asn, Arg, Leu, or Thr

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  Xaa is Asp, Asn, or Ser

<220>
<221>  VARIANT
<222>  (15)..(15)
<223>  Xaa is Ser, Ala, Thr, Gly, or Arg

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  Xaa is Ile, Leu, Phe, Ser, Arg, Tyr, Gln, Trp, Asp, Lys, or His

<220>
<221>  VARIANT
<222>  (17)..(17)
<223>  Xaa is Asp, Ser, Ile, Asn, Glu, Ala, His, Phe, Leu, Gln, Met, 
       Gly, Tyr, or Val

<220>
<221>  VARIANT
<222>  (19)..(19)
<223>  Xaa is Lys, Leu, Arg, Met, Thr, or Phe

<220>
<221>  VARIANT
<222>  (20)..(20)
<223>  Xaa is Val, Leu, Ile, Ala, or Thr

<220>
<221>  VARIANT
<222>  (21)..(21)
<223>  Xaa is Leu, Ile, Val, or Ala

<220>
<221>  VARIANT
<222>  (22)..(22)
<223>  Xaa is Thr, Val, Cys, Glu, Ser, or Ala

<220>
<221>  VARIANT
<222>  (23)..(23)
<223>  Xaa is Arg, Phe, Thr, Trp, Glu, Leu, Asn, Cys, Lys, Val, Ser, 
       Gln, Ile, Tyr, His, or Ala

<220>
<221>  VARIANT
<222>  (24)..(24)
<223>  Xaa is Ser, Pro, Arg, Lys, Asn, Ala, His, Gln, Gly, or Leu

<220>
<221>  VARIANT
<222>  (25)..(25)
<223>  Xaa is Asp, Gly, Thr, Asn, Ser, Lys, Ala, Ile, Glu, Leu, Gln, 
       Arg, or Tyr

<220>
<221>  VARIANT
<222>  (26)..(26)
<223>  Xaa is Lys, Val, Ala, Glu, Tyr, Ile, Cys, Leu, Ser, Thr, Gly, 
       Lys, Met, Asp, or Phe

<400>  25

Xaa Xaa Xaa His Xaa Xaa Pro Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Asn Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asn 
            20                  25          


<210>  26
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HNH-like domain


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Asp or Glu

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is Leu, Ile, Arg, Gln, Val, Met, or Lys

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is Asp or Glu

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa is Ile, Val, Thr, Ala, or Leu

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa is Val, Tyr, Ile, Leu, Phe, or Trp

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa is Gln, His, Arg, Lys, Tyr, Ile, Leu, Phe, or Trp

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa is Phe, Leu, Val, Lys, Tyr, Met, Ile, Arg, Ala, Glu, Asp, or 
       Gln

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Xaa is Leu, Arg, Thr, Ile, Val, Ser, Cys, Tyr, Lys, Phe, or Gly

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Xaa is Lys, Gln, Tyr, Thr, Phe, Leu, Trp, Met, Ala, Glu, Gly, or 
       Ser

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  Xaa is Ile, Leu, Phe, Ser, Arg, Tyr, Gln, Trp, Asp, Lys, or His

<220>
<221>  VARIANT
<222>  (17)..(17)
<223>  Xaa is Asp, Ser, Ile, Asn, Glu, Ala, His, Phe, Leu, Gln, Met, 
       Gly, Tyr, or Val

<220>
<221>  VARIANT
<222>  (22)..(22)
<223>  Xaa is Thr, Val, Cys, Glu, Ser, or Ala

<220>
<221>  VARIANT
<222>  (23)..(23)
<223>  Xaa is Arg, Phe, Thr, Trp, Glu, Leu, Asn, Cys, Lys, Val, Ser, 
       Gln, Ile, Tyr, His, or Ala

<220>
<221>  VARIANT
<222>  (24)..(24)
<223>  Xaa is Ser, Pro, Arg, Lys, Asn, Ala, His, Gln, Gly, or Leu

<220>
<221>  VARIANT
<222>  (25)..(25)
<223>  Xaa is Asp, Gly, Thr, Asn, Ser, Lys, Ala, Ile, Glu, Leu, Gln, 
       Arg, or Tyr

<220>
<221>  VARIANT
<222>  (26)..(26)
<223>  Xaa is Lys, Val, Ala, Glu, Tyr, Ile, Cys, Leu, Ser, Thr, Gly, 
       Lys, Met, Asp, or Phe

<400>  26

Xaa Xaa Xaa His Xaa Xaa Pro Xaa Ser Xaa Xaa Xaa Asp Asp Ser Xaa 
1               5                   10                  15      


Xaa Asn Lys Val Leu Xaa Xaa Xaa Xaa Xaa Asn 
            20                  25          


<210>  27
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HNH-like domain


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Asp or Glu

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is Asp or Glu

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa is Gln, His, Arg, Lys, Tyr, Ile, Leu, or Trp

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa is Phe, Leu, Val, Lys, Tyr, Met, Ile, Arg, Ala, Glu, Asp, or 
       Gln

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Xaa is Leu, Arg, Thr, Ile, Val, Ser, Cys, Tyr, Lys, Phe, or Gly

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Xaa is Lys, Gln, Tyr, Thr, Phe, Leu, Trp, Met, Ala, Glu, Gly, or 
       Ser

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  Xaa is Ile, Leu, Phe, Ser, Arg, Tyr, Gln, Trp, Asp, Lys, or His

<220>
<221>  VARIANT
<222>  (17)..(17)
<223>  Xaa is Asp, Ser, Ile, Asn, Glu, Ala, His, Phe, Leu, Gln, Met, 
       Gly, Tyr, or Val

<220>
<221>  VARIANT
<222>  (23)..(23)
<223>  Xaa is Arg, Phe, Thr, Trp, Glu, Leu, Asn, Cys, Lys, Val, Ser, 
       Gln, Ile, Tyr, His, or Ala

<220>
<221>  VARIANT
<222>  (24)..(24)
<223>  Xaa is Ser, Pro, Arg, Lys, Asn, Ala, His, Gln, Gly, or Leu

<220>
<221>  VARIANT
<222>  (25)..(25)
<223>  Xaa is Asp, Gly, Thr, Asn, Ser, Lys, Ala, Ile, Glu, Leu, Gln, 
       Arg, or Tyr

<220>
<221>  VARIANT
<222>  (26)..(26)
<223>  Xaa is Lys, Val, Ala, Glu, Tyr, Ile, Cys, Leu, Ser, Thr, Gly, 
       Lys, Met, Asp, or Phe

<400>  27

Xaa Val Xaa His Ile Val Pro Xaa Ser Xaa Xaa Xaa Asp Asp Ser Xaa 
1               5                   10                  15      


Xaa Asn Lys Val Leu Thr Xaa Xaa Xaa Xaa Asn 
            20                  25          


<210>  28
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HNH-like domain


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is Ile or Val

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa is Ile or Val

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa is Ala or Ser

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Xaa is Ile or Leu

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Xaa is Lys or Thr

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  Xaa is Asp or Asn

<220>
<221>  VARIANT
<222>  (19)..(19)
<223>  Xaa is Arg, Lys, or Leu

<220>
<221>  VARIANT
<222>  (22)..(22)
<223>  Xaa is Thr or Val

<220>
<221>  VARIANT
<222>  (23)..(23)
<223>  Xaa is Ser or Arg

<220>
<221>  VARIANT
<222>  (25)..(25)
<223>  Xaa is Lys, Asp, or Ala

<220>
<221>  VARIANT
<222>  (26)..(26)
<223>  Xaa is Glu, Lys, Gly, or Asn

<400>  28

Asp Xaa Asp His Ile Xaa Pro Gln Xaa Phe Xaa Xaa Asp Xaa Ser Ile 
1               5                   10                  15      


Asp Asn Xaa Val Leu Xaa Xaa Ser Xaa Xaa Asn 
            20                  25          


<210>  29
<211>  116
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  a, c, u, g, unknown or other

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  targeting region

<220>
<221>  misc_feature
<222>  (21)..(42)
<223>  first complementarity domain

<220>
<221>  misc_feature
<222>  (43)..(46)
<223>  linking domain

<220>
<221>  misc_feature
<222>  (47)..(70)
<223>  second complementarity domain

<400>  29
nnnnnnnnnn nnnnnnnnnn guuuuagagc uaugcuguuu uggaaacaaa acagcauagc       60

aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu ggcaccgagu cggugc          116


<210>  30
<211>  116
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  a, c, u, g, unknown or other

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  targeting region

<220>
<221>  misc_feature
<222>  (21)..(42)
<223>  first complementarity domain

<220>
<221>  misc_feature
<222>  (43)..(46)
<223>  linking domain

<220>
<221>  misc_feature
<222>  (47)..(70)
<223>  second complementarity domain

<400>  30
nnnnnnnnnn nnnnnnnnnn guauuagagc uaugcuguau uggaaacaau acagcauagc       60

aaguuaauau aaggcuaguc cguuaucaac uugaaaaagu ggcaccgagu cggugc          116


<210>  31
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  a, c, u, g, unknown or other

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  targeting domain

<220>
<221>  misc_feature
<222>  (21)..(32)
<223>  first complementarity domain

<220>
<221>  misc_feature
<222>  (33)..(36)
<223>  linking domain

<220>
<221>  misc_feature
<222>  (37)..(50)
<223>  second complementarity domain

<220>
<221>  misc_feature
<222>  (51)..(62)
<223>  proximal domain

<400>  31
nnnnnnnnnn nnnnnnnnnn guuuaagagc uagaaauagc aaguuuaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugc                                 96


<210>  32
<211>  47
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA proximal and tail domains derived from S. pyogenes

<400>  32
aaggcuaguc cguuaucaac uugaaaaagu ggcaccgagu cggugcu                     47


<210>  33
<211>  49
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA proximal and tail domains

<400>  33
aaggcuaguc cguuaucaac uugaaaaagu ggcaccgagu cgguggugc                   49


<210>  34
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA proximal and tail domains

<400>  34
aaggcuaguc cguuaucaac uugaaaaagu ggcaccgagu cggugcggau c                51


<210>  35
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA proximal and tail domains

<400>  35
aaggcuaguc cguuaucaac uugaaaaagu g                                      31


<210>  36
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA proximal and tail domains

<400>  36
aaggcuaguc cguuauca                                                     18


<210>  37
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA proximal and tail domains

<400>  37
aaggcuaguc cg                                                           12


<210>  38
<211>  102
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Unimolecular gRNA derived from S. aureus


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Targeting domain

<400>  38
nnnnnnnnnn nnnnnnnnnn guuuuaguac ucuggaaaca gaaucuacua aaacaaggca       60

aaaugccgug uuuaucucgu caacuuguug gcgagauuuu uu                         102


<210>  39
<211>  42
<212>  RNA
<213>  Artificial

<220>
<223>  Modular gRNA derived from S. pyogenes


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  a, c, u, g, unknown or other

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Targeting domain

<220>
<221>  misc_feature
<222>  (21)..(42)
<223>  First complementarity domain

<400>  39
nnnnnnnnnn nnnnnnnnnn guuuuagagc uaugcuguuu ug                          42


<210>  40
<211>  85
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modular gRNA derived from S. pyogenes


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  5' extension domain

<220>
<221>  misc_feature
<222>  (10)..(33)
<223>  Second complementarity domain

<220>
<221>  misc_feature
<222>  (34)..(45)
<223>  Proximal domain

<220>
<221>  misc_feature
<222>  (46)..(85)
<223>  Tail domain

<400>  40
ggaaccauuc aaaacagcau agcaaguuaa aauaaggcua guccguuauc aacuugaaaa       60

aguggcaccg agucggugcu uuuuu                                             85


<210>  41
<211>  62
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Unimolecular gRNA derived from S. pyogenes


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  a, c, u, g, unknown or other

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Targeting domain

<220>
<221>  misc_feature
<222>  (21)..(32)
<223>  First complementarity domain

<220>
<221>  misc_feature
<222>  (33)..(36)
<223>  Linking domain

<220>
<221>  misc_feature
<222>  (37)..(50)
<223>  Second complementarity domain

<220>
<221>  misc_feature
<222>  (51)..(62)
<223>  Proximal domain

<400>  41
nnnnnnnnnn nnnnnnnnnn guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cg                                                                      62


<210>  42
<211>  102
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Unimolecular gRNA derived from S. pyogenes


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  a, c, u, g, unknown or other

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Targeting domain

<220>
<221>  misc_feature
<222>  (21)..(32)
<223>  First complementarity domain

<220>
<221>  misc_feature
<222>  (33)..(36)
<223>  Linking domain

<220>
<221>  misc_feature
<222>  (37)..(50)
<223>  Second complementarity domain

<220>
<221>  misc_feature
<222>  (51)..(62)
<223>  Proximal domain

<220>
<221>  misc_feature
<222>  (63)..(102)
<223>  Tail domain

<400>  42
nnnnnnnnnn nnnnnnnnnn guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu uu                         102


<210>  43
<211>  75
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Unimolecular gRNA derived from S. pyogenes


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Targeting domain

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  a, c, u, g, unknown or other

<220>
<221>  misc_feature
<222>  (21)..(36)
<223>  First complementarity domain

<220>
<221>  misc_feature
<222>  (37)..(40)
<223>  Linking domain

<220>
<221>  misc_feature
<222>  (41)..(58)
<223>  Second complementarity domain

<220>
<221>  misc_feature
<222>  (59)..(70)
<223>  Proximal domain

<220>
<221>  misc_feature
<222>  (71)..(75)
<223>  Tail domain

<400>  43
nnnnnnnnnn nnnnnnnnnn guuuuagagc uaugcugaaa agcauagcaa guuaaaauaa       60

ggcuaguccg uuauc                                                        75


<210>  44
<211>  87
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Unimolecular gRNA derived from S. pyogenes


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  a, c, u, g, unknown or other

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Targeting domain

<220>
<221>  misc_feature
<222>  (21)..(32)
<223>  First complementarity domain

<220>
<221>  misc_feature
<222>  (43)..(46)
<223>  Linking domain

<220>
<221>  misc_feature
<222>  (57)..(70)
<223>  Second complementarity domain

<220>
<221>  misc_feature
<222>  (71)..(82)
<223>  Proximal domain

<220>
<221>  misc_feature
<222>  (83)..(87)
<223>  Tail domain

<400>  44
nnnnnnnnnn nnnnnnnnnn guuuuagagc uaugcuguuu uggaaacaaa acagcauagc       60

aaguuaaaau aaggcuaguc cguuauc                                           87


<210>  45
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modular gRNA derived from S. thermophilus


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  a, c, u, g, unknown or other

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Targeting domain

<220>
<221>  misc_feature
<222>  (21)..(42)
<223>  First complementarity domain

<400>  45
nnnnnnnnnn nnnnnnnnnn guuuuagagc uguguuguuu cg                          42


<210>  46
<211>  78
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modular gRNA derived from S. thermophilus


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  5' extension domain

<220>
<221>  misc_feature
<222>  (4)..(27)
<223>  Second complementarity domain

<220>
<221>  misc_feature
<222>  (28)..(40)
<223>  Proximal domain

<220>
<221>  misc_feature
<222>  (41)..(78)
<223>  Tail domain

<400>  46
gggcgaaaca acacagcgag uuaaaauaag gcuuaguccg uacucaacuu gaaaaggugg       60

caccgauucg guguuuuu                                                     78


<210>  47
<211>  85
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modular gRNA derived from S. pyogenes

<400>  47
gaaccauuca aaacagcaua gcaaguuaaa auaaggcuag uccguuauca acuugaaaaa       60

guggcaccga gucggugcuu uuuuu                                             85


<210>  48
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA from S. pyogenes


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Targeting domain

<400>  48
nnnnnnnnnn nnnnnnnnnn guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugc                                 96


<210>  49
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Targeting domain

<220>
<221>  misc_feature
<222>  (21)..(32)
<223>  First complementarity domain

<220>
<221>  misc_feature
<222>  (33)..(36)
<223>  Linking domain

<220>
<221>  misc_feature
<222>  (37)..(50)
<223>  Second complementarity domain

<220>
<221>  misc_feature
<222>  (51)..(62)
<223>  Proximal domain

<400>  49
nnnnnnnnnn nnnnnnnnnn guauuagagc uagaaauagc aaguuaauau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugc                                 96


<210>  50
<211>  104
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Targeting domain

<220>
<221>  misc_feature
<222>  (21)..(36)
<223>  First complementarity domain

<220>
<221>  misc_feature
<222>  (37)..(40)
<223>  Linking domain

<220>
<221>  misc_feature
<222>  (41)..(58)
<223>  Second complementarity domain

<400>  50
nnnnnnnnnn nnnnnnnnnn guuuuagagc uaugcugaaa agcauagcaa guuaaaauaa       60

ggcuaguccg uuaucaacuu gaaaaagugg caccgagucg gugc                       104


<210>  51
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Targeting domain

<220>
<221>  misc_feature
<222>  (21)..(37)
<223>  First complementarity domain

<220>
<221>  misc_feature
<222>  (38)..(41)
<223>  Linking domain

<220>
<221>  misc_feature
<222>  (42)..(60)
<223>  Second complementarity domain

<400>  51
nnnnnnnnnn nnnnnnnnnn guuuuagagc uaugcuggaa acagcauagc aaguuaaaau       60

aaggcuaguc cguuaucaac uugaaaaagu ggcaccgagu cggugc                     106


<210>  52
<211>  12
<212>  PRT
<213>  Peptoniphilus duerdenii

<400>  52

Asp Ile Gly Thr Ala Ser Val Gly Trp Ala Val Thr 
1               5                   10          


<210>  53
<211>  12
<212>  PRT
<213>  Treponema denticola

<400>  53

Asp Val Gly Thr Gly Ser Val Gly Trp Ala Val Thr 
1               5                   10          


<210>  54
<211>  12
<212>  PRT
<213>  S. mutans

<400>  54

Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Val 
1               5                   10          


<210>  55
<211>  12
<212>  PRT
<213>  S. pyogenes

<400>  55

Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile 
1               5                   10          


<210>  56
<211>  12
<212>  PRT
<213>  L. innocua

<400>  56

Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Leu 
1               5                   10          


<210>  57
<211>  12
<212>  PRT
<213>  Flavobacterium branchiophilum FL-15

<400>  57

Asp Leu Gly Thr Asn Ser Ile Gly Trp Ala Val Val 
1               5                   10          


<210>  58
<211>  11
<212>  PRT
<213>  Pedobacter glucosidilyticus

<400>  58

Asp Leu Gly Thr Asn Ser Ile Gly Trp Ala Ile 
1               5                   10      


<210>  59
<211>  12
<212>  PRT
<213>  Bacteroides fragilis, NCTC 9343

<400>  59

Asp Leu Gly Thr Asn Ser Ile Gly Trp Ala Leu Val 
1               5                   10          


<210>  60
<211>  12
<212>  PRT
<213>  Fusobacterium nucleatum

<400>  60

Asp Ile Gly Thr Asn Ser Val Gly Trp Cys Val Thr 
1               5                   10          


<210>  61
<211>  12
<212>  PRT
<213>  Acidaminococcus sp. D21

<400>  61

Asp Ile Gly Thr Asn Ser Val Gly Tyr Ala Val Thr 
1               5                   10          


<210>  62
<211>  12
<212>  PRT
<213>  Coprococcus catus GD-7

<400>  62

Asp Met Gly Thr Gly Ser Leu Gly Trp Ala Val Thr 
1               5                   10          


<210>  63
<211>  12
<212>  PRT
<213>  Oenococcus kitaharae DSM 17330

<400>  63

Asp Ile Gly Thr Ser Ser Val Gly Trp Ala Ala Ile 
1               5                   10          


<210>  64
<211>  12
<212>  PRT
<213>  Catenibacterium mitsuokai DSM 15897

<400>  64

Asp Leu Gly Thr Gly Ser Val Gly Trp Ala Val Val 
1               5                   10          


<210>  65
<211>  12
<212>  PRT
<213>  Mycoplasma gallisepticum str. F

<400>  65

Asp Leu Gly Val Gly Ser Val Gly Trp Ala Ile Val 
1               5                   10          


<210>  66
<211>  12
<212>  PRT
<213>  Mycoplasma ovipneumoniae SC01

<400>  66

Asp Leu Gly Ile Ala Ser Ile Gly Trp Ala Ile Ile 
1               5                   10          


<210>  67
<211>  12
<212>  PRT
<213>  Mycoplasma canis PG 14

<400>  67

Asp Leu Gly Ile Ala Ser Val Gly Trp Ala Ile Val 
1               5                   10          


<210>  68
<211>  12
<212>  PRT
<213>  Mycoplasma synoviae 53

<400>  68

Asp Leu Gly Val Ala Ser Val Gly Trp Ser Ile Val 
1               5                   10          


<210>  69
<211>  12
<212>  PRT
<213>  Eubacterium rectale

<400>  69

Asp Ile Gly Ile Ala Ser Val Gly Trp Ala Ile Leu 
1               5                   10          


<210>  70
<211>  12
<212>  PRT
<213>  Enterococcus faecalis TX0012

<400>  70

Asp Leu Gly Ile Ser Ser Val Gly Trp Ser Val Ile 
1               5                   10          


<210>  71
<211>  12
<212>  PRT
<213>  Ilyobacter polytropus DSM 2926

<400>  71

Asp Ile Gly Ile Ala Ser Val Gly Trp Ser Val Ile 
1               5                   10          


<210>  72
<211>  12
<212>  PRT
<213>  Ruminococcus albus 8

<400>  72

Asp Val Gly Ile Gly Ser Ile Gly Trp Ala Val Ile 
1               5                   10          


<210>  73
<211>  12
<212>  PRT
<213>  Elusimicrobium minutum Pei191

<400>  73

Asp Leu Gly Val Gly Ser Ile Gly Phe Ala Ile Val 
1               5                   10          


<210>  74
<211>  12
<212>  PRT
<213>  Akkermansia muciniphila

<400>  74

Asp Ile Gly Tyr Ala Ser Ile Gly Trp Ala Val Ile 
1               5                   10          


<210>  75
<211>  12
<212>  PRT
<213>  Prevotella ruminicola

<400>  75

Asp Thr Gly Thr Asn Ser Leu Gly Trp Ala Ile Val 
1               5                   10          


<210>  76
<211>  12
<212>  PRT
<213>  Cand. Puniceispirillum marinum

<400>  76

Asp Leu Gly Thr Asn Ser Ile Gly Trp Cys Leu Leu 
1               5                   10          


<210>  77
<211>  12
<212>  PRT
<213>  Rhodospirillum rubrum

<400>  77

Asp Ile Gly Thr Asp Ser Leu Gly Trp Ala Val Phe 
1               5                   10          


<210>  78
<211>  12
<212>  PRT
<213>  Lactobacillus rhamnosus GG

<400>  78

Asp Ile Gly Ser Asn Ser Ile Gly Phe Ala Val Val 
1               5                   10          


<210>  79
<211>  12
<212>  PRT
<213>  Sphaerochaeta globus str. Buddy

<400>  79

Asp Leu Gly Val Gly Ser Ile Gly Val Ala Val Ala 
1               5                   10          


<210>  80
<211>  12
<212>  PRT
<213>  Rhodopseudomonas palustris

<400>  80

Asp Leu Gly Ile Ala Ser Cys Gly Trp Gly Val Val 
1               5                   10          


<210>  81
<211>  12
<212>  PRT
<213>  Mycoplasma mobile 163K

<400>  81

Asp Leu Gly Ile Ala Ser Val Gly Trp Cys Leu Thr 
1               5                   10          


<210>  82
<211>  12
<212>  PRT
<213>  Streptococcus thermophilus LMD-9

<400>  82

Asp Ile Gly Ile Gly Ser Val Gly Val Gly Ile Leu 
1               5                   10          


<210>  83
<211>  12
<212>  PRT
<213>  Staphylococcus lugdunensis M23590

<400>  83

Asp Ile Gly Ile Thr Ser Val Gly Tyr Gly Leu Ile 
1               5                   10          


<210>  84
<211>  12
<212>  PRT
<213>  Eubacterium dolichum DSM 3991

<400>  84

Asp Ile Gly Ile Thr Ser Val Gly Phe Gly Ile Ile 
1               5                   10          


<210>  85
<211>  12
<212>  PRT
<213>  Lactobacillus coryniformis KCTC 3535

<400>  85

Asp Val Gly Ile Thr Ser Thr Gly Tyr Ala Val Leu 
1               5                   10          


<210>  86
<211>  12
<212>  PRT
<213>  Nitratifractor salsuginis DSM 16511

<400>  86

Asp Leu Gly Ile Thr Ser Phe Gly Tyr Ala Ile Leu 
1               5                   10          


<210>  87
<211>  12
<212>  PRT
<213>  Bifidobacterium bifidum S17

<400>  87

Asp Ile Gly Asn Ala Ser Val Gly Trp Ser Ala Phe 
1               5                   10          


<210>  88
<211>  12
<212>  PRT
<213>  Lactobacillus gasseri

<400>  88

Asp Val Gly Thr Asn Ser Cys Gly Trp Val Ala Met 
1               5                   10          


<210>  89
<211>  12
<212>  PRT
<213>  Acidothermus cellulolyticus 11B

<400>  89

Asp Val Gly Glu Arg Ser Ile Gly Leu Ala Ala Val 
1               5                   10          


<210>  90
<211>  12
<212>  PRT
<213>  Bifidobacterium longum DJO10A

<400>  90

Asp Val Gly Leu Asn Ser Val Gly Leu Ala Ala Val 
1               5                   10          


<210>  91
<211>  12
<212>  PRT
<213>  Bifidobacterium dentium

<400>  91

Asp Val Gly Leu Met Ser Val Gly Leu Ala Ala Ile 
1               5                   10          


<210>  92
<211>  12
<212>  PRT
<213>  Corynebacterium diphtheriae

<400>  92

Asp Val Gly Thr Phe Ser Val Gly Leu Ala Ala Ile 
1               5                   10          


<210>  93
<211>  12
<212>  PRT
<213>  Staphylococcus pseudintermedius ED99

<400>  93

Asp Ile Gly Thr Gly Ser Val Gly Tyr Ala Cys Met 
1               5                   10          


<210>  94
<211>  12
<212>  PRT
<213>  Capnocytophaga ochracea

<400>  94

Asp Leu Gly Thr Thr Ser Ile Gly Phe Ala His Ile 
1               5                   10          


<210>  95
<211>  12
<212>  PRT
<213>  Prevotella denticola

<400>  95

Asp Leu Gly Thr Asn Ser Ile Gly Ser Ser Val Arg 
1               5                   10          


<210>  96
<211>  12
<212>  PRT
<213>  Ralstonia solanacearum

<400>  96

Asp Ile Gly Thr Asn Ser Ile Gly Trp Ala Val Ile 
1               5                   10          


<210>  97
<211>  12
<212>  PRT
<213>  Pasteurella multocida str. Pm70

<400>  97

Asp Leu Gly Ile Ala Ser Val Gly Trp Ala Val Val 
1               5                   10          


<210>  98
<211>  12
<212>  PRT
<213>  Comamonas granuli

<400>  98

Asp Ile Gly Ile Ala Ser Val Gly Trp Ala Val Leu 
1               5                   10          


<210>  99
<211>  12
<212>  PRT
<213>  Helicobacter mustelae 12198

<400>  99

Asp Ile Gly Ile Ala Ser Ile Gly Trp Ala Val Ile 
1               5                   10          


<210>  100
<211>  12
<212>  PRT
<213>  Agathobacter rectalis

<400>  100

Asp Ile Gly Ile Ala Ser Val Gly Trp Ala Ile Ile 
1               5                   10          


<210>  101
<211>  12
<212>  PRT
<213>  Clostridium cellulolyticum H10

<400>  101

Asp Val Gly Ile Ala Ser Val Gly Trp Ala Val Ile 
1               5                   10          


<210>  102
<211>  11
<212>  PRT
<213>  Methylophilus sp. OH31

<400>  102

Asp Ile Gly Ile Ala Ser Val Gly Trp Ala Leu 
1               5                   10      


<210>  103
<211>  12
<212>  PRT
<213>  Neisseria meningitidis

<400>  103

Asp Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val 
1               5                   10          


<210>  104
<211>  12
<212>  PRT
<213>  Clostridium perfringens

<400>  104

Asp Ile Gly Ile Thr Ser Val Gly Trp Ala Val Ile 
1               5                   10          


<210>  105
<211>  12
<212>  PRT
<213>  Wolinella succinogenes DSM 1740

<400>  105

Asp Leu Gly Ile Ser Ser Leu Gly Trp Ala Ile Val 
1               5                   10          


<210>  106
<211>  12
<212>  PRT
<213>  Azospirillum sp. B510

<400>  106

Asp Leu Gly Thr Asn Ser Ile Gly Trp Gly Leu Leu 
1               5                   10          


<210>  107
<211>  12
<212>  PRT
<213>  Verminephrobacter eiseniae

<400>  107

Asp Leu Gly Ser Thr Ser Leu Gly Trp Ala Ile Phe 
1               5                   10          


<210>  108
<211>  12
<212>  PRT
<213>  Campylobacter jejuni, NCTC 11168

<400>  108

Asp Ile Gly Ile Ser Ser Ile Gly Trp Ala Phe Ser 
1               5                   10          


<210>  109
<211>  12
<212>  PRT
<213>  Parvibaculum lavamentivorans DS-1

<400>  109

Asp Ile Gly Thr Thr Ser Ile Gly Phe Ser Val Ile 
1               5                   10          


<210>  110
<211>  12
<212>  PRT
<213>  Dinoroseobacter shibae DFL 12

<400>  110

Asp Ile Gly Thr Ser Ser Ile Gly Trp Trp Leu Tyr 
1               5                   10          


<210>  111
<211>  12
<212>  PRT
<213>  Nitrobacter hamburgensis X14

<400>  111

Asp Leu Gly Ser Asn Ser Leu Gly Trp Phe Val Thr 
1               5                   10          


<210>  112
<211>  12
<212>  PRT
<213>  Bradyrhizobium sp. BTAi1

<400>  112

Asp Leu Gly Ala Asn Ser Leu Gly Trp Phe Val Val 
1               5                   10          


<210>  113
<211>  15
<212>  PRT
<213>  Bacillus cereus

<400>  113

Asp Ile Gly Leu Arg Ile Gly Ile Thr Ser Cys Gly Trp Ser Ile 
1               5                   10                  15  


<210>  114
<211>  12
<212>  PRT
<213>  Sutterella wadsworthensis

<400>  114

Asp Met Gly Ala Lys Tyr Thr Gly Val Phe Tyr Ala 
1               5                   10          


<210>  115
<211>  12
<212>  PRT
<213>  Wolinella succinogenes DSM 1740

<400>  115

Asp Leu Gly Gly Lys Asn Thr Gly Phe Phe Ser Phe 
1               5                   10          


<210>  116
<211>  12
<212>  PRT
<213>  Francisella tularensis

<400>  116

Asp Leu Gly Val Lys Asn Thr Gly Val Phe Ser Ala 
1               5                   10          


<210>  117
<211>  12
<212>  PRT
<213>  Gamma proteobacterium HTCC5015

<400>  117

Asp Leu Gly Ala Lys Phe Thr Gly Val Ala Leu Tyr 
1               5                   10          


<210>  118
<211>  12
<212>  PRT
<213>  Legionella pneumophila str. Paris

<400>  118

Asp Leu Gly Gly Lys Phe Thr Gly Val Cys Leu Ser 
1               5                   10          


<210>  119
<211>  12
<212>  PRT
<213>  Parasutterella excrementihominis

<400>  119

Asp Leu Gly Gly Thr Tyr Thr Gly Thr Phe Ile Thr 
1               5                   10          


<210>  120
<211>  12
<212>  PRT
<213>  S. thermophilus

<400>  120

Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Thr 
1               5                   10          


<210>  121
<211>  12
<212>  PRT
<213>  Eubacterium yurii

<400>  121

Asp Val Gly Thr Asn Ser Val Gly Trp Ala Val Thr 
1               5                   10          


<210>  122
<211>  12
<212>  PRT
<213>  Butyrivibrio hungatei

<400>  122

Asp Met Gly Thr Asn Ser Val Gly Trp Ala Val Thr 
1               5                   10          


<210>  123
<211>  12
<212>  PRT
<213>  Solobacterium moorei F0204

<400>  123

Asp Val Gly Thr Ser Ser Val Gly Trp Ala Val Thr 
1               5                   10          


<210>  124
<211>  27
<212>  PRT
<213>  Treponema denticola

<400>  124

Asp Ile Asp His Ile Tyr Pro Gln Ser Lys Ile Lys Asp Asp Ser Ile 
1               5                   10                  15      


Ser Asn Arg Val Leu Val Cys Ser Ser Cys Asn 
            20                  25          


<210>  125
<211>  27
<212>  PRT
<213>  Coprococcus catus GD-7

<400>  125

Asp Ile Asp His Ile Tyr Pro Gln Ser Lys Thr Met Asp Asp Ser Leu 
1               5                   10                  15      


Asn Asn Arg Val Leu Val Lys Lys Asn Tyr Asn 
            20                  25          


<210>  126
<211>  27
<212>  PRT
<213>  Peptoniphilus duerdenii

<400>  126

Asp Gln Asp His Ile Tyr Pro Lys Ser Lys Ile Tyr Asp Asp Ser Leu 
1               5                   10                  15      


Glu Asn Arg Val Leu Val Lys Lys Asn Leu Asn 
            20                  25          


<210>  127
<211>  27
<212>  PRT
<213>  Catenibacterium mitsuokai DSM 15897

<400>  127

Gln Ile Asp His Ile Val Pro Gln Ser Leu Val Lys Asp Asp Ser Phe 
1               5                   10                  15      


Asp Asn Arg Val Leu Val Val Pro Ser Glu Asn 
            20                  25          


<210>  128
<211>  27
<212>  PRT
<213>  S. mutans

<400>  128

Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys Asp Asn Ser Ile 
1               5                   10                  15      


Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn 
            20                  25          


<210>  129
<211>  27
<212>  PRT
<213>  S. thermophilus

<400>  129

Asp Ile Asp His Ile Ile Pro Gln Ala Phe Leu Lys Asp Asn Ser Ile 
1               5                   10                  15      


Asp Asn Lys Val Leu Val Ser Ser Ala Ser Asn 
            20                  25          


<210>  130
<211>  27
<212>  PRT
<213>  Oenococcus kitaharae DSM 17330

<400>  130

Asp Ile Asp His Ile Ile Pro Gln Ala Tyr Thr Lys Asp Asn Ser Leu 
1               5                   10                  15      


Asp Asn Arg Val Leu Val Ser Asn Ile Thr Asn 
            20                  25          


<210>  131
<211>  27
<212>  PRT
<213>  L. inocua

<400>  131

Asp Ile Asp His Ile Val Pro Gln Ser Phe Ile Thr Asp Asn Ser Ile 
1               5                   10                  15      


Asp Asn Leu Val Leu Thr Ser Ser Ala Gly Asn 
            20                  25          


<210>  132
<211>  27
<212>  PRT
<213>  S. pyogenes

<400>  132

Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile 
1               5                   10                  15      


Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn 
            20                  25          


<210>  133
<211>  27
<212>  PRT
<213>  Acidaminococcus sp. D21

<400>  133

Asn Ile Asp His Ile Tyr Pro Gln Ser Met Val Lys Asp Asp Ser Leu 
1               5                   10                  15      


Asp Asn Lys Val Leu Val Gln Ser Glu Ile Asn 
            20                  25          


<210>  134
<211>  27
<212>  PRT
<213>  Lactobacillus rhamnosus GG

<400>  134

Asp Ile Asp His Ile Leu Pro Gln Ser Leu Ile Lys Asp Asp Ser Leu 
1               5                   10                  15      


Asp Asn Arg Val Leu Val Asn Ala Thr Ile Asn 
            20                  25          


<210>  135
<211>  27
<212>  PRT
<213>  Lactobacillus gasseri

<400>  135

Asp Ile Asp His Ile Leu Pro Gln Ser Phe Ile Lys Asp Asp Ser Leu 
1               5                   10                  15      


Glu Asn Arg Val Leu Val Lys Lys Ala Val Asn 
            20                  25          


<210>  136
<211>  27
<212>  PRT
<213>  Staphylococcus pseudintermedius ED99

<400>  136

Glu Val Asp His Ile Phe Pro Arg Ser Phe Ile Lys Asp Asp Ser Ile 
1               5                   10                  15      


Asp Asn Lys Val Leu Val Ile Lys Lys Met Asn 
            20                  25          


<210>  137
<211>  27
<212>  PRT
<213>  Olsenella uli

<400>  137

Glu Val Asp His Ile Ile Pro Arg Ser Tyr Ile Lys Asp Asp Ser Phe 
1               5                   10                  15      


Glu Asn Lys Val Leu Val Tyr Arg Glu Glu Asn 
            20                  25          


<210>  138
<211>  27
<212>  PRT
<213>  Bifidobacterium bifidum S17

<400>  138

Asp Ile Asp His Ile Ile Pro Gln Ala Val Thr Gln Asn Asp Ser Ile 
1               5                   10                  15      


Asp Asn Arg Val Leu Val Ala Arg Ala Glu Asn 
            20                  25          


<210>  139
<211>  27
<212>  PRT
<213>  Mycoplasma gallisepticum str. F

<400>  139

Glu Ile Asp His Ile Ile Pro Tyr Ser Ile Ser Phe Asp Asp Ser Ser 
1               5                   10                  15      


Ser Asn Lys Leu Leu Val Leu Ala Glu Ser Asn 
            20                  25          


<210>  140
<211>  27
<212>  PRT
<213>  Mycoplasma canis PG 14

<400>  140

Glu Ile Asp His Ile Ile Pro Tyr Ser Leu Cys Phe Asp Asp Ser Ser 
1               5                   10                  15      


Ala Asn Lys Val Leu Val His Lys Gln Ser Asn 
            20                  25          


<210>  141
<211>  27
<212>  PRT
<213>  Ilyobacter polytropus DSM 2926

<400>  141

Asp Ile Asp His Ile Ile Pro Tyr Ser Arg Ser Met Asp Asp Ser Tyr 
1               5                   10                  15      


Ser Asn Lys Val Leu Val Leu Ser Gly Glu Asn 
            20                  25          


<210>  142
<211>  27
<212>  PRT
<213>  Uncultured Termite group 1 bacterium

<400>  142

Asp Ile Asp His Ile Ile Pro Tyr Ser Lys Ser Met Asp Asp Ser Phe 
1               5                   10                  15      


Asn Asn Lys Val Leu Cys Leu Ala Glu Glu Asn 
            20                  25          


<210>  143
<211>  27
<212>  PRT
<213>  Campylobacter jejuni

<400>  143

Glu Ile Asp His Ile Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr 
1               5                   10                  15      


Met Asn Lys Val Leu Val Phe Thr Lys Gln Asn 
            20                  25          


<210>  144
<211>  27
<212>  PRT
<213>  Clostridium cellulolyticum H10

<400>  144

Gln Ile Asp His Ile Tyr Pro Tyr Ser Arg Ser Met Asp Asp Ser Tyr 
1               5                   10                  15      


Met Asn Lys Val Leu Val Leu Thr Asp Glu Asn 
            20                  25          


<210>  145
<211>  27
<212>  PRT
<213>  Clostridium perfringens

<400>  145

Glu Ile Asp His Ile Ile Pro Phe Ser Arg Ser Phe Asp Asp Ser Leu 
1               5                   10                  15      


Ser Asn Lys Ile Leu Val Leu Gly Ser Glu Asn 
            20                  25          


<210>  146
<211>  27
<212>  PRT
<213>  N. meningitides

<400>  146

Glu Ile Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe 
1               5                   10                  15      


Asn Asn Lys Val Leu Val Leu Gly Ser Glu Asn 
            20                  25          


<210>  147
<211>  27
<212>  PRT
<213>  Pasteurella multocida str. Pm70

<400>  147

Glu Ile Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe 
1               5                   10                  15      


Asn Asn Lys Val Leu Val Leu Ala Ser Glu Asn 
            20                  25          


<210>  148
<211>  27
<212>  PRT
<213>  Enterococcus faecalis TX0012

<400>  148

Glu Ile Asp His Ile Ile Pro Ile Ser Ile Ser Leu Asp Asp Ser Ile 
1               5                   10                  15      


Asn Asn Lys Val Leu Val Leu Ser Lys Ala Asn 
            20                  25          


<210>  149
<211>  27
<212>  PRT
<213>  Eubacterium dolichum DSM 3991

<400>  149

Glu Val Asp His Ile Ile Pro Ile Ser Ile Ser Leu Asp Asp Ser Ile 
1               5                   10                  15      


Thr Asn Lys Val Leu Val Thr His Arg Glu Asn 
            20                  25          


<210>  150
<211>  27
<212>  PRT
<213>  Acidovorax ebreus

<400>  150

Gln Val Asp His Ala Leu Pro Tyr Ser Arg Ser Tyr Asp Asp Ser Lys 
1               5                   10                  15      


Asn Asn Lys Val Leu Val Leu Thr His Glu Asn 
            20                  25          


<210>  151
<211>  27
<212>  PRT
<213>  Streptococcus thermophilus LMD-9

<400>  151

Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp Asp Ser Leu 
1               5                   10                  15      


Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn 
            20                  25          


<210>  152
<211>  27
<212>  PRT
<213>  Eubacterium rectale

<400>  152

Glu Ile Asp His Ile Ile Pro Arg Ser Ile Ser Phe Asp Asp Ala Arg 
1               5                   10                  15      


Ser Asn Lys Val Leu Val Tyr Arg Ser Glu Asn 
            20                  25          


<210>  153
<211>  27
<212>  PRT
<213>  Staphylococcus lugdunensis M23590

<400>  153

Glu Val Asp His Ile Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Tyr 
1               5                   10                  15      


His Asn Lys Val Leu Val Lys Gln Ser Glu Asn 
            20                  25          


<210>  154
<211>  27
<212>  PRT
<213>  Roseburia intestinalis

<400>  154

Asp Ile Asp His Ile Leu Pro Tyr Ser Ile Thr Phe Asp Asp Ser Phe 
1               5                   10                  15      


Arg Asn Lys Val Leu Val Thr Ser Gln Glu Asn 
            20                  25          


<210>  155
<211>  27
<212>  PRT
<213>  Wolinella succinogenes DSM 1740

<400>  155

Glu Ile Asp His Ile Leu Pro Arg Ser Arg Ser Ala Asp Asp Ser Phe 
1               5                   10                  15      


Ala Asn Lys Val Leu Cys Leu Ala Arg Ala Asn 
            20                  25          


<210>  156
<211>  27
<212>  PRT
<213>  Cand. Puniceispirillum marinum

<400>  156

Glu Ile Glu His Leu Leu Pro Phe Ser Leu Thr Leu Asp Asp Ser Met 
1               5                   10                  15      


Ala Asn Lys Thr Val Cys Phe Arg Gln Ala Asn 
            20                  25          


<210>  157
<211>  27
<212>  PRT
<213>  Azospirillum sp. B510

<400>  157

Asp Ile Asp His Ile Leu Pro Phe Ser Val Ser Leu Asp Asp Ser Ala 
1               5                   10                  15      


Ala Asn Lys Val Val Cys Leu Arg Glu Ala Asn 
            20                  25          


<210>  158
<211>  27
<212>  PRT
<213>  Bradyrhizobium sp. BTAi1

<400>  158

Asp Ile Asp His Leu Ile Pro Phe Ser Ile Ser Trp Asp Asp Ser Ala 
1               5                   10                  15      


Ala Asn Lys Val Val Cys Met Arg Tyr Ala Asn 
            20                  25          


<210>  159
<211>  27
<212>  PRT
<213>  Nitrobacter hamburgensis X14

<400>  159

Asp Ile Asp His Ile Leu Pro Val Ala Met Thr Leu Asp Asp Ser Pro 
1               5                   10                  15      


Ala Asn Lys Ile Ile Cys Met Arg Tyr Ala Asn 
            20                  25          


<210>  160
<211>  27
<212>  PRT
<213>  Dinoroseobacter shibae

<400>  160

Asp Val Asp His Ile Leu Pro Tyr Ser Arg Thr Leu Asp Asp Ser Phe 
1               5                   10                  15      


Pro Asn Arg Thr Leu Cys Leu Arg Glu Ala Asn 
            20                  25          


<210>  161
<211>  27
<212>  PRT
<213>  Verminephrobacter eiseniae

<400>  161

Glu Ile Glu His Ile Leu Pro Phe Ser Arg Thr Leu Asp Asp Ser Leu 
1               5                   10                  15      


Asn Asn Arg Thr Val Ala Met Arg Arg Ala Asn 
            20                  25          


<210>  162
<211>  27
<212>  PRT
<213>  Lactobacillus coryniformis KCTC 3535

<400>  162

Glu Val Asp His Ile Ile Pro Tyr Ser Ile Ser Trp Asp Asp Ser Tyr 
1               5                   10                  15      


Thr Asn Lys Val Leu Thr Ser Ala Lys Cys Asn 
            20                  25          


<210>  163
<211>  27
<212>  PRT
<213>  Rhodopseudomonas palustris

<400>  163

Gln Val Asp His Ile Leu Pro Trp Ser Arg Phe Gly Asp Asp Ser Tyr 
1               5                   10                  15      


Leu Asn Lys Thr Leu Cys Thr Ala Arg Ser Asn 
            20                  25          


<210>  164
<211>  27
<212>  PRT
<213>  Ralstonia syzygii R24

<400>  164

Gln Val Asp His Ile Leu Pro Phe Ser Lys Thr Leu Asp Asp Ser Phe 
1               5                   10                  15      


Ala Asn Lys Val Leu Ala Gln His Asp Ala Asn 
            20                  25          


<210>  165
<211>  27
<212>  PRT
<213>  Helicobacter mustelae 12198

<400>  165

Gln Ile Asp His Ala Phe Pro Leu Ser Arg Ser Leu Asp Asp Ser Gln 
1               5                   10                  15      


Ser Asn Lys Val Leu Cys Leu Thr Ser Ser Asn 
            20                  25          


<210>  166
<211>  27
<212>  PRT
<213>  Mycoplasma mobile 163K

<400>  166

Asp Ile Asp His Ile Val Pro Arg Ser Ile Ser Phe Asp Asp Ser Phe 
1               5                   10                  15      


Ser Asn Leu Val Ile Val Asn Lys Leu Asp Asn 
            20                  25          


<210>  167
<211>  27
<212>  PRT
<213>  Mycoplasma ovipneumoniae SC01

<400>  167

Glu Ile Glu His Ile Ile Pro Tyr Ser Met Ser Tyr Asp Asn Ser Gln 
1               5                   10                  15      


Ala Asn Lys Ile Leu Thr Glu Lys Ala Glu Asn 
            20                  25          


<210>  168
<211>  27
<212>  PRT
<213>  Mycoplasma synoviae 53

<400>  168

Glu Ile Asp His Val Ile Pro Tyr Ser Lys Ser Ala Asp Asp Ser Trp 
1               5                   10                  15      


Phe Asn Lys Leu Leu Val Lys Lys Ser Thr Asn 
            20                  25          


<210>  169
<211>  27
<212>  PRT
<213>  Aminomonas paucivorans DSM 12260

<400>  169

Glu Met Asp His Ile Leu Pro Tyr Ser Arg Ser Leu Asp Asn Gly Trp 
1               5                   10                  15      


His Asn Arg Val Leu Val His Gly Lys Asp Asn 
            20                  25          


<210>  170
<211>  27
<212>  PRT
<213>  Ruminococcus albus 8

<400>  170

Glu Val Asp His Ile Val Pro Tyr Ser Leu Ile Leu Asp Asn Thr Ile 
1               5                   10                  15      


Asn Asn Lys Ala Leu Val Tyr Ala Glu Glu Asn 
            20                  25          


<210>  171
<211>  27
<212>  PRT
<213>  Fibrobacter succinogenes

<400>  171

Glu Ile Glu His Val Ile Pro Gln Ser Leu Tyr Phe Asp Asp Ser Phe 
1               5                   10                  15      


Ser Asn Lys Val Ile Cys Glu Ala Glu Val Asn 
            20                  25          


<210>  172
<211>  27
<212>  PRT
<213>  Bacteroides fragilis, NCTC 9343

<400>  172

Asp Ile Glu His Ile Ile Pro Gln Ala Arg Leu Phe Asp Asp Ser Phe 
1               5                   10                  15      


Ser Asn Lys Thr Leu Glu Ala Arg Ser Val Asn 
            20                  25          


<210>  173
<211>  27
<212>  PRT
<213>  Capnocytophaga sputigena

<400>  173

Glu Ile Glu His Ile Val Pro Lys Ala Arg Val Phe Asp Asp Ser Phe 
1               5                   10                  15      


Ser Asn Lys Thr Leu Thr Phe His Arg Ile Asn 
            20                  25          


<210>  174
<211>  28
<212>  PRT
<213>  Finegoldia magna

<400>  174

Asp Lys Asp His Ile Ile Pro Gln Ser Met Lys Lys Asp Asp Ser Ile 
1               5                   10                  15      


Ile Asn Asn Leu Val Leu Val Asn Lys Asn Ala Asn 
            20                  25              


<210>  175
<211>  27
<212>  PRT
<213>  Parvibaculum lavamentivorans DS-1

<400>  175

Glu Val Glu His Ile Trp Pro Arg Ser Arg Ser Phe Asp Asn Ser Pro 
1               5                   10                  15      


Arg Asn Lys Thr Leu Cys Arg Lys Asp Val Asn 
            20                  25          


<210>  176
<211>  27
<212>  PRT
<213>  Bacillus cereus

<400>  176

Ile Val Asn His Ile Ile Pro Tyr Asn Arg Ser Phe Asp Asp Thr Tyr 
1               5                   10                  15      


His Asn Arg Val Leu Thr Leu Thr Glu Thr Lys 
            20                  25          


<210>  177
<211>  27
<212>  PRT
<213>  Prevotella micans

<400>  177

Asp Met Glu His Thr Ile Pro Lys Ser Ile Ser Phe Asp Asn Ser Asp 
1               5                   10                  15      


Gln Asn Leu Thr Leu Cys Glu Ser Tyr Tyr Asn 
            20                  25          


<210>  178
<211>  27
<212>  PRT
<213>  Prevotella ruminicola

<400>  178

Asp Ile Glu His Thr Ile Pro Arg Ser Ala Gly Gly Asp Ser Thr Lys 
1               5                   10                  15      


Met Asn Leu Thr Leu Cys Ser Ser Arg Phe Asn 
            20                  25          


<210>  179
<211>  27
<212>  PRT
<213>  Flavobacterium columnare

<400>  179

Asp Ile Glu His Thr Ile Pro Arg Ser Ile Ser Gln Asp Asn Ser Gln 
1               5                   10                  15      


Met Asn Lys Thr Leu Cys Ser Leu Lys Phe Asn 
            20                  25          


<210>  180
<211>  27
<212>  PRT
<213>  Rhodospirillum rubrum

<400>  180

Asp Ile Asp His Val Ile Pro Leu Ala Arg Gly Gly Arg Asp Ser Leu 
1               5                   10                  15      


Asp Asn Met Val Leu Cys Gln Ser Asp Ala Asn 
            20                  25          


<210>  181
<211>  27
<212>  PRT
<213>  Elusimicrobium minutum Pei191

<400>  181

Asp Ile Glu His Leu Phe Pro Ile Ala Glu Ser Glu Asp Asn Gly Arg 
1               5                   10                  15      


Asn Asn Leu Val Ile Ser His Ser Ala Cys Asn 
            20                  25          


<210>  182
<211>  27
<212>  PRT
<213>  Sphaerochaeta globus str. Buddy

<400>  182

Asp Val Asp His Ile Phe Pro Arg Asp Asp Thr Ala Asp Asn Ser Tyr 
1               5                   10                  15      


Gly Asn Lys Val Val Ala His Arg Gln Cys Asn 
            20                  25          


<210>  183
<211>  27
<212>  PRT
<213>  Nitratifractor salsuginis DSM 16511

<400>  183

Asp Ile Glu His Ile Val Pro Gln Ser Leu Gly Gly Leu Ser Thr Asp 
1               5                   10                  15      


Tyr Asn Thr Ile Val Thr Leu Lys Ser Val Asn 
            20                  25          


<210>  184
<211>  27
<212>  PRT
<213>  Acidothermus cellulolyticus 11B

<400>  184

Glu Leu Asp His Ile Val Pro Arg Thr Asp Gly Gly Ser Asn Arg His 
1               5                   10                  15      


Glu Asn Leu Ala Ile Thr Cys Gly Ala Cys Asn 
            20                  25          


<210>  185
<211>  28
<212>  PRT
<213>  Bifidobacterium longum DJO10A

<400>  185

Glu Met Asp His Ile Val Pro Arg Lys Gly Val Gly Ser Thr Asn Thr 
1               5                   10                  15      


Arg Thr Asn Phe Ala Ala Val Cys Ala Glu Cys Asn 
            20                  25              


<210>  186
<211>  28
<212>  PRT
<213>  Bifidobacterium dentium

<400>  186

Glu Met Asp His Ile Val Pro Arg Lys Gly Val Gly Ser Thr Asn Thr 
1               5                   10                  15      


Arg Val Asn Leu Ala Ala Ala Cys Ala Ala Cys Asn 
            20                  25              


<210>  187
<211>  28
<212>  PRT
<213>  Corynebacterium diphtheria

<400>  187

Glu Met Asp His Ile Val Pro Arg Ala Gly Gln Gly Ser Thr Asn Thr 
1               5                   10                  15      


Arg Glu Asn Leu Val Ala Val Cys His Arg Cys Asn 
            20                  25              


<210>  188
<211>  33
<212>  PRT
<213>  Sutterella wadsworthensis

<400>  188

Glu Ile Asp His Ile Leu Pro Arg Ser Leu Ile Lys Asp Ala Arg Gly 
1               5                   10                  15      


Ile Val Phe Asn Ala Glu Pro Asn Leu Ile Tyr Ala Ser Ser Arg Gly 
            20                  25                  30          


Asn 
    


<210>  189
<211>  33
<212>  PRT
<213>  Gamma proteobacterium HTCC5015

<400>  189

Glu Ile Asp His Ile Ile Pro Arg Ser Leu Thr Gly Arg Thr Lys Lys 
1               5                   10                  15      


Thr Val Phe Asn Ser Glu Ala Asn Leu Ile Tyr Cys Ser Ser Lys Gly 
            20                  25                  30          


Asn 
    


<210>  190
<211>  33
<212>  PRT
<213>  Parasutterella excrementihominis

<400>  190

Glu Ile Asp His Ile Ile Pro Arg Ser Leu Thr Leu Lys Lys Ser Glu 
1               5                   10                  15      


Ser Ile Tyr Asn Ser Glu Val Asn Leu Ile Phe Val Ser Ala Gln Gly 
            20                  25                  30          


Asn 
    


<210>  191
<211>  33
<212>  PRT
<213>  Legionella pneumophila str. Paris

<400>  191

Glu Ile Asp His Ile Tyr Pro Arg Ser Leu Ser Lys Lys His Phe Gly 
1               5                   10                  15      


Val Ile Phe Asn Ser Glu Val Asn Leu Ile Tyr Cys Ser Ser Gln Gly 
            20                  25                  30          


Asn 
    


<210>  192
<211>  33
<212>  PRT
<213>  Wolinella succinogenes DSM 1740

<400>  192

Glu Ile Asp His Ile Leu Pro Arg Ser His Thr Leu Lys Ile Tyr Gly 
1               5                   10                  15      


Thr Val Phe Asn Pro Glu Gly Asn Leu Ile Tyr Val His Gln Lys Cys 
            20                  25                  30          


Asn 
    


<210>  193
<211>  30
<212>  PRT
<213>  Francisella tularensis

<400>  193

Glu Leu Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu 
1               5                   10                  15      


Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg Gly Asp Asn 
            20                  25                  30  


<210>  194
<211>  27
<212>  PRT
<213>  Akkermansia muciniphila

<400>  194

Glu Leu Glu His Ile Val Pro His Ser Phe Arg Gln Ser Asn Ala Leu 
1               5                   10                  15      


Ser Ser Leu Val Leu Thr Trp Pro Gly Val Asn 
            20                  25          


<210>  195
<211>  27
<212>  PRT
<213>  Solobacterium moorei F0204

<400>  195

Asp Ile Asp His Ile Tyr Pro Arg Ser Lys Ile Lys Asp Asp Ser Ile 
1               5                   10                  15      


Thr Asn Arg Val Leu Val Glu Lys Asp Ile Asn 
            20                  25          


<210>  196
<211>  28
<212>  PRT
<213>  Veillonella atypica ACS-134-V-Col7a

<400>  196

Tyr Asp Ile Asp His Ile Tyr Pro Arg Ser Leu Thr Lys Asp Asp Ser 
1               5                   10                  15      


Phe Asp Asn Leu Val Leu Cys Glu Arg Thr Ala Asn 
            20                  25              


<210>  197
<211>  28
<212>  PRT
<213>  Fusobacterium nucleatum

<400>  197

Asp Ile Asp His Ile Tyr Pro Arg Ser Lys Val Ile Lys Asp Asp Ser 
1               5                   10                  15      


Phe Asp Asn Leu Val Leu Val Leu Lys Asn Glu Asn 
            20                  25              


<210>  198
<211>  27
<212>  PRT
<213>  Filifactor alocis

<400>  198

Asp Arg Asp His Ile Tyr Pro Gln Ser Lys Ile Lys Asp Asp Ser Ile 
1               5                   10                  15      


Asp Asn Leu Val Leu Val Asn Lys Thr Tyr Asn 
            20                  25          


<210>  199
<211>  5
<212>  DNA
<213>  Streptococcus thermophilus


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Any nucleotide (e.g., A, G, C, or T)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Any nucleotide (e.g., A, G, C, or T)

<400>  199
nggng                                                                    5


<210>  200
<211>  7
<212>  DNA
<213>  Streptococcus thermophilus


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Any nucleotide (e.g., A, G, C, or T)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Any nucleotide (e.g., A, G, C, or T)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  A or T

<400>  200
nnagaaw                                                                  7


<210>  201
<211>  4
<212>  DNA
<213>  Streptococcus mutans


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Any nucleotide (e.g., A, G, C, or T)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  A or G

<400>  201
naar                                                                     4


<210>  202
<211>  5
<212>  DNA
<213>  Staphylococcus aureus


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Any nucleotide (e.g., A, G, C, or T)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Any nucleotide (e.g., A, G, C, or T)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  A or G

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  A or G

<400>  202
nngrr                                                                    5


<210>  203
<211>  6
<212>  DNA
<213>  Staphylococcus aureus


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Any nucleotide (e.g., A, G, C, or T)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Any nucleotide (e.g., A, G, C, or T)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  A or G

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  A or G

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Any nucleotide (e.g., A, G, C, or T)

<400>  203
nngrrn                                                                   6


<210>  204
<211>  6
<212>  DNA
<213>  Staphylococcus aureus


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Any nucleotide (e.g., A, G, C, or T)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Any nucleotide (e.g., A, G, C, or T)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  A or G

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  A or G

<400>  204
nngrrt                                                                   6


<210>  205
<211>  6
<212>  DNA
<213>  Staphylococcus aureus


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Any nucleotide (e.g., A, G, C, or T)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Any nucleotide (e.g., A, G, C, or T)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  A or G

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  A or G

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  A, G, or C

<400>  205
nngrrv                                                                   6


<210>  206
<211>  80
<212>  DNA
<213>  Streptococcus pyogenes

<400>  206
gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt       60

ggcaccgagt cggtgctttt                                                   80


<210>  207
<211>  80
<212>  DNA
<213>  Staphylococcus aureus

<400>  207
gttttagtac tctggaaaca gaatctacta aaacaaggca aaatgccgtg tttatctcgt       60

caacttgttg gcgagatttt                                                   80


<210>  208
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA molecule

<400>  208
guaacggcag acuucuccuc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  209
<211>  101
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA molecule

<400>  209
gguaacggca gacuucuccu cguuuuagag cuagaaauag caaguuaaaa uaaggcuagu       60

ccguuaucaa cuugaaaaag uggcaccgag ucggugcuuu u                          101


<210>  210
<211>  102
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA molecule

<400>  210
ggguaacggc agacuucucc ucguuuuaga gcuagaaaua gcaaguuaaa auaaggcuag       60

uccguuauca acuugaaaaa guggcaccga gucggugcuu uu                         102


