                               SEQUENCE LISTING

<110>  MINA THERAPEUTICS LIMITED
 
<120>  C/EBP ALPHA SARNA COMPOSITIONS AND METHODS OF USE

<130>  P068174WO

<150>  US 62/150,889
<151>  2015-04-22

<150>  US 62/235,778
<151>  2015-10-01

<150>  US 62/308,521
<151>  2016-03-15

<160> 129

<170> PatentIn version 3.5

<210> 1
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1
cggucauugu cacugguca                                                    19


<210> 2
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
ugaccaguga caaugaccg                                                    19


<210> 3
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
agcugaaagg auucauccu                                                    19


<210> 4
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 4
aggaugaauc cuuccagcu                                                    19


<210> 5
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
acauaguccc agugauuaa                                                    19


<210> 6
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
uuaaucacug ggacuaugu                                                    19


<210> 7
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
gaauaagacu uuguccaau                                                    19


<210> 8
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
auuggacaaa gucuuauuc                                                    19


<210> 9
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
gcgcggauuc ucuuucaaa                                                    19


<210> 10
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
uuugaaagag aauccgcgc                                                    19


<210> 11
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
ccaggaacuc gucguugaa                                                    19


<210> 12
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
uucaacgacg aguuccugg                                                    19


<210> 13
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
agaaguuggc cacuuccau                                                    19


<210> 14
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
auggagucgg ccgacuucu                                                    19


<210> 15
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
aagaggucgg agaggaagu                                                    19


<210> 16
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 16
aguuccuggc cgaccuguu                                                    19


<210> 17
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 17
uuguacucgu cgcugugcu                                                    19


<210> 18
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 18
agaacagcaa cgaguaccg                                                    19


<210> 19
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
uacucgucgc ugugcuugu                                                    19


<210> 20
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
acaagaacag caacgagua                                                    19


<210> 21
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 21
agaaguuggc cacuuccaug gggga                                             25


<210> 22
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 22
tcccccaugg agucggccga cuucuac                                           27


<210> 23
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 23
aagaggucgg agaggaaguc gucgt                                             25


<210> 24
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 24
acgacgaguu ccuggccgac cuguucc                                           27


<210> 25
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 25
uuguacucgu cgcugugcuu gucca                                             25


<210> 26
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 26
tggacaagaa cagcaacgag uaccggg                                           27


<210> 27
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 27
uacucgucgc ugugcuuguc caccg                                             25


<210> 28
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 28
cgguggacaa gaacagcaac gaguacc                                           27


<210> 29
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 29
cugaguaauc gcuuaaagau u                                                 21


<210> 30
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
ucuuuaagcg auuacucagu u                                                 21


<210> 31
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 31
gaaacuuuag cgagucagau u                                                 21


<210> 32
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 32
ucugacucgc uaaaguuucu u                                                 21


<210> 33
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 33
acuacugagu gacaguagau u                                                 21


<210> 34
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Sense strand starting at position 17 of SEQ ID NO: 67

<400> 34
gguauacauc cucagagcu                                                    19


<210> 35
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Antisense strand to SEQ ID NO: 34

<400> 35
agcucugagg auguauacc                                                    19


<210> 36
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Sense strand starting at position 46 of SEQ ID NO: 67

<400> 36
cuagcuuucu ggugugacu                                                    19


<210> 37
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Antisense strand to SEQ ID NO: 36

<400> 37
agucacacca gaaagcuag                                                    19


<210> 38
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Sense strand starting at position 305 of SEQ ID NO: 67

<400> 38
cgggcuuguc gggaucuca                                                    19


<210> 39
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Antisense strand to SEQ ID NO: 37

<400> 39
ugagaucccg acaagcccg                                                    19


<210> 40
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Sense strand starting at position 457 of SEQ ID NO: 67

<400> 40
gcauuggagc ggugaguuu                                                    19


<210> 41
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Antisense strand to SEQ ID NO: 40

<400> 41
aaacucaccg cuccaaugc                                                    19


<210> 42
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Sense strand starting at position 486 of SEQ ID NO: 67

<400> 42
ggcacaaggu uauccuaaa                                                    19


<210> 43
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Antisense strand to SEQ ID NO: 42

<400> 43
uuuaggauaa ccuugugcc                                                    19


<210> 44
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Sense strand starting at position 487 of SEQ ID NO: 67

<400> 44
gcacaagguu auccuaaau                                                    19


<210> 45
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Antisense strand to SEQ ID NO: 44

<400> 45
auuuaggaua accuugugc                                                    19


<210> 46
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Sense strand starting at position 883 of SEQ ID NO: 67

<400> 46
cggucauugu cacugguca                                                    19


<210> 47
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Antisense strand to SEQ ID NO: 46

<400> 47
ugaccaguga caaugaccg                                                    19


<210> 48
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Sense strand starting at position 1616 of SEQ ID NO: 67

<400> 48
ccaggaacuc gucguugaa                                                    19


<210> 49
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Antisense strand to SEQ ID NO: 48

<400> 49
uucaacgacg aguuccugg                                                    19


<210> 50
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 50
cggucauugu cacuggucau u                                                 21


<210> 51
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 51
ugaccaguga caaugaccgu u                                                 21


<210> 52
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(2)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'O-Me modified nucleotide

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<400> 52
cggucauugu cacuggucau u                                                 21


<210> 53
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(2)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (19)..(21)
<223> 2'O-Me modified nucleotide

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<400> 53
ugaccaguga caaugaccgu u                                                 21


<210> 54
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(2)
<223> 2'O-Me modified nucleotide

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> Inverted nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> Deoxy-nucleotide

<400> 54
cggucauugu cacuggucat                                                   20


<210> 55
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(2)
<223> 2'F modified nucleotide

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (19)..(21)
<223> 2'O-Me modified nucleotide

<220>
<221> misc_feature
<222> (19)..(21)
<223> Phosphorothioate linkage

<400> 55
ugaccaguga caaugaccgu u                                                 21


<210> 56
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted nucleotide

<220>
<221> modified_base
<222> (1)..(1)
<223> Deoxy-nucleotide

<220>
<221> modified_base
<222> (2)..(3)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> Inverted nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> Deoxy-nucleotide

<400> 56
tcggucauug ucacugguca t                                                 21


<210> 57
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted nucleotide

<220>
<221> modified_base
<222> (1)..(1)
<223> Deoxy-nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (3)..(4)
<223> Deoxy-nucleotide

<220>
<221> modified_base
<222> (5)..(6)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> Deoxy-nucleotide

<220>
<221> modified_base
<222> (8)..(9)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> Deoxy-nucleotide

<220>
<221> modified_base
<222> (11)..(12)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> Deoxy-nucleotide

<220>
<221> modified_base
<222> (14)..(15)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (16)..(17)
<223> Deoxy-nucleotide

<220>
<221> modified_base
<222> (18)..(19)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> Deoxy-nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> Inverted nucleotide

<400> 57
tcggucauug ucacugguca t                                                 21


<210> 58
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (2)..(3)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (4)..(5)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (6)..(7)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (9)..(10)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (12)..(13)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (15)..(16)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (17)..(18)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (19)..(21)
<223> 2'O-Me modified nucleotide

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<400> 58
ugaccaguga caaugaccgu u                                                 21


<210> 59
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(2)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (22)..(23)
<223> 2'O-Me modified nucleotide

<220>
<221> misc_feature
<222> (22)..(23)
<223> Phosphorothioate linkage

<400> 59
gcggucauug ucacuggucu uuu                                               23


<210> 60
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(2)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (21)..(23)
<223> 2'O-Me modified nucleotide

<220>
<221> misc_feature
<222> (22)..(23)
<223> Phosphorothioate linkage

<400> 60
aagaccagug acaaugaccg cuu                                               23


<210> 61
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(2)
<223> 2'O-Me modified nucleotide

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> Inverted nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> Deoxy-nucleotide

<400> 61
gcggucauug ucacuggucu ut                                                22


<210> 62
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(2)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'F modified nucleotide

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(23)
<223> 2'O-Me modified nucleotide

<220>
<221> misc_feature
<222> (22)..(23)
<223> Phosphorothioate linkage

<400> 62
aagaccagug acaaugaccg cuu                                               23


<210> 63
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted nucleotide

<220>
<221> modified_base
<222> (1)..(1)
<223> Deoxy-nucleotide

<220>
<221> modified_base
<222> (2)..(3)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> Inverted nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> Deoxy-nucleotide

<400> 63
tgcggucauu gucacugguc uut                                               23


<210> 64
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted nucleotide

<220>
<221> modified_base
<222> (1)..(2)
<223> Deoxy-nucleotide 

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (4)..(5)
<223> Deoxy-nucleotide

<220>
<221> modified_base
<222> (6)..(7)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> Deoxy-nucleotide

<220>
<221> modified_base
<222> (9)..(10)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> Deoxy-nucleotide

<220>
<221> modified_base
<222> (12)..(13)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> Deoxy-nucleotide

<220>
<221> modified_base
<222> (15)..(16)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (17)..(18)
<223> Deoxy-nucleotide

<220>
<221> modified_base
<222> (19)..(22)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> Inverted nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> Deoxy-nucleotide

<400> 64
tgcggucauu gucacugguc uut                                               23


<210> 65
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(2)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (3)..(4)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (5)..(6)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (8)..(9)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (11)..(12)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (14)..(15)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (16)..(17)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (19)..(21)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (22)..(23)
<223> 2'O-Me modified nucleotide

<220>
<221> misc_feature
<222> (22)..(23)
<223> Phosphorothioate linkage

<400> 65
gaccagugac aaugaccgcu uuu                                               23


<210> 66
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(2)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (22)..(23)
<223> 2'O-Me modified nucleotide

<220>
<221> misc_feature
<222> (22)..(23)
<223> Phosphorothioate linkage

<400> 66
ugaaaggauu cauccuccuu uuu                                               23


<210> 67
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(2)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (21)..(23)
<223> 2'O-Me modified nucleotide

<220>
<221> misc_feature
<222> (22)..(23)
<223> Phosphorothioate linkage

<400> 67
aaaggaggau gaauccuuuc auu                                               23


<210> 68
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(2)
<223> 2'O-Me modified nucleotide

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> Inverted nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> Deoxy-nucleotide

<400> 68
ugaaaggauu cauccuccuu ut                                                22


<210> 69
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(2)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (21)..(23)
<223> 2'O-Me modified nucleotide

<220>
<221> misc_feature
<222> (21)..(23)
<223> Phosphorothioate linkage

<400> 69
aaaggaggau gaauccuuuc auu                                               23


<210> 70
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted nucleotide

<220>
<221> modified_base
<222> (1)..(1)
<223> Deoxy-nucleotide

<220>
<221> modified_base
<222> (2)..(3)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> Inverted nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> Deoxy-nucleotide

<400> 70
tugaaaggau ucauccuccu uut                                               23


<210> 71
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted nucleotide

<220>
<221> modified_base
<222> (1)..(1)
<223> Deoxy-nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (3)..(9)
<223> Deoxy-nucleotide

<220>
<221> modified_base
<222> (10)..(12)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> Deoxy-nucleotide

<220>
<221> modified_base
<222> (14)..(22)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> Inverted nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> Deoxy-nucleotide

<400> 71
tugaaaggau ucauccuccu uut                                               23


<210> 72
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(7)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (9)..(11)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (12)..(18)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'O-Me modified nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'F modified nucleotide

<220>
<221> modified_base
<222> (22)..(23)
<223> 2'O-Me modified nucleotide

<220>
<221> misc_feature
<222> (22)..(23)
<223> Phosphorothioate linkage

<400> 72
aggaggauga auccuuucau uuu                                               23


<210> 73
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 73
gcggucauug ucacuggucu u                                                 21


<210> 74
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 74
ugaaaggauu cauccuccuu u                                                 21


<210> 75
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 75
gaccagugac aaugaccgcu u                                                 21


<210> 76
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 76
aggaggauga auccuuucau u                                                 21


<210> 77
<211> 4001
<212> DNA
<213> Homo sapiens

<400> 77
tccctctccc accaggggta tacatcctca gagctgaccc acgacctagc tttctggtgt       60

gactcggggt gggggctccc actggtcacc tggtgacccc catcgcagtg agttccgccc      120

caaggggaag cccagcctat agcaggctgg ggtggggtgt gtgcggaggg aggtgggaga      180

ggcgtggaac tagagaccct ccaccttcat gtagaactag gggaacaacc ttaggttcca      240

agccccaagt ccctatgttt ccaccccttt ctaaggacag gcgtggagga gcggctgggg      300

ctggcgggct tgtcgggatc tcagctccct gagccctcct cctgccacgg gcctgctccc      360

ctccttctct catgggggtc tgctgtagcc tcgggaagga ggcaggaaac ctccaaataa      420

aatgacaagg cacgatttgc tccccctact cagtaggcat tggagcggtg agtttgcatt      480

tccaaggcac aaggttatcc taaatactag agttgccggg ctcccagctc agccccaaga      540

attctcccct cctcgcaggg agaagccacc gcctggcccc ctcatcttag acgcaccaag      600

tccggcgcag aggaagggag gggacacgcg gagcaggcca ggctttcagg aggcaccgga      660

atctcctagt cctggctcgc acggctcggg caagcctcga gatccggcga ccccaaacca      720

ctccctgggt ccccgccgga ggctggccca gggcggtccc acagccgcgc gcctcacgcg      780

cagttgccca tggccttgac caaggagctc tctggcagct ggcggaagat gccccgcagc      840

gtgtccagtt cgcggctcag ctgttccacc cgcttgcgca ggcggtcatt gtcactggtc      900

agctccagca ccttctgctg cgtctccacg ttgcgctgct tggccttgtc gcggctcttg      960

cgcaccgcga tgttgttgcg ctcgcgccgc acccggtact cgttgctgtt cttgtccacc     1020

gacttcttgg ccttgcccgc gccgctgccg ccactcgcgc ggaggtcggg gtgcgcggcg     1080

cccagcccct tgagcgcgct gccagggccc ggcaggccgg cggcaccgag cgcgggcgcg     1140

gggtgcgggc tgggcacggg cgtgggcggc ggcgtggggt gaccgggctg caggtgcatg     1200

gtggtctggc cgcagtgcgc gatctggaac tgcaggtgcg gggcggccag gtgcgcgggc     1260

ggcgggtgcg ggtgcgggtg cgagggcggc ggcggcggcg gcggctggta agggaagagg     1320

ccggccagcg ccagctgctt ggcttcatcc tcctcgcggg gctcctgctt gatcaccagc     1380

ggccgcagcg ccggcgcccc gacgcgctcg tacaggggct ccagcctgcc gtccaggtag     1440

ccggcggccg cgcagccgta gccgggcggg ggcccgtgcg ctcccccggg catgacggcg     1500

ccgccggggc ccgcgggcgc gcccgggtag tcaaagtcgc cgccgccgcc gccgcccgtg     1560

gggcccacgg ccgccttggc cttctcctgc tgccggctgt gctggaacag gtcggccagg     1620

aactcgtcgt tgaaggcggc cgggtcgatg taggcgctga tgtcgatgga cgtctcgtgc     1680

tcgcagatgc cgcccagcgg ctccggggcg gcaggtgggg cgggaggctg cgcggggccc     1740

gcgccccggg gaaagccgaa ggcggcgctg ctgggcgcgt gcggggggct ctgcaggtgg     1800

ctgctcatcg ggggccgcgg ctccgcctcg tagaagtcgg ccgactccat gggggagtta     1860

gagttctccc ggcatggcga gcctcggcgg cctccagcct gcgcggggcg tcgccgccgc     1920

ccacccggag accctgctcg cccgcgcccg cgcacctccg ggtcgcgaat ggcccggccc     1980

gcgccggccc agcttttata cccggcaggc cgcgtcgccc cctagagtcc gaggcggcct     2040

ctgtccccgg gctgcggcgg cgcggcgcct gctgggtcct agcgcgcggc cggcatgggg     2100

cggcgaacca gcgcggcaca gcgccgcgct ccccaggcag gccgcggcgc aacgcccacc     2160

gcctccagcg cgcccagcag agccgcggcg ctcgctccaa gctccgcccc cggcccggcc     2220

gtcgcccccg cgcccacgtg gtcggtagcg ggggccccct cctcctgcct gccctaggcg     2280

cccgtatcca gccacggccg ggagcccagg agtatcccga ggctgcacgg ggtaggggtg     2340

gggggcggag ggcgagtctt ggtcttgagc tgctggggcg cggattctct ttcaaagcca     2400

gaaccaggcc tgtcccggac ccgcgtcccg gggaggctgc agcgcagagc agcggggctg     2460

gggccggtgg ggggccgttt gggacgcgcg gagaggtcct gagcgcggtg gctctgcgtc     2520

tcctagctct gatctccagg ctacccctgt gattccgcgc agaggtacct ctcggaggac     2580

gccggggtcc catgggcggc gccgcgcagg gcgctaggac cccgcgggga gcggaggcgg     2640

cctcggcccg ggagcctgga ggacctggcc ggtcgatccg cccgggctgg aaaactttct     2700

ttataattac ttctccaggt cggagcgcgc ggcttgctag gcgcgcgggg ccggcgctgt     2760

tacccggcgt ggagtcgccg attttttttc ctgcgggacc gcggggcccc ccagactagc     2820

ggagctggac gccggggcga gcacggggag gggcgcaccg agggaggaga caaacttaac     2880

tctggggccg ggattccgag gcgggggccg cagccctcga ggcccgaagc caccgcttcc     2940

tcccccgcct ccccattcag gtgggcgcca acggcgggag cgagggtgtc caggccgccg     3000

ggctgccagg tccgagcacg cacagggaga actctgccca gtggttcgcc gggcgctgta     3060

gtccccggga tcctagggac cgaggcggcc aggccctggg gccccttgag tgcggcagct     3120

aatgctctca ccgcggcggg ggaaggagct tgccaccgag acccccagcc acgtgcgtcc     3180

ctcgcattct ttaccggggc cggggtggcg gctacggacc gtcagctggg cccagatgga     3240

gtcttgggag ccctcaagtg tctcctgtcc ttgcccgcgc cgcccctcgc cactggcgct     3300

gaggcctgac gccgcctgcg tcccggctag aggcgcgctt gcctacaggt gagggaagac     3360

ccccttcacc gacagtggcc ttaggcctgg caaggcgcca cgacccgccc aggagccccg     3420

gagggggcac agctaaaaac accgctggag agccccgagc ttccacgacg atcgcagtaa     3480

agaagcagtt tcatctgggc aacgcacact gcgctttaat caagttccta ttcaacatag     3540

tcccagtgat taatagccca actgcttcgt tttcggtcca gagctcataa acaagatatt     3600

tttagcttga cgcttttgga cgggagggag taaaaaccag atacgttaaa taaatatccc     3660

gatgtgagcc ggagagctgc ttgctgagcc aaatgcagga cccattcata tagcattcac     3720

ctgtggaggg agacctggac ggaaatcaaa aagcaccaag agcgatttgc gtttttttct     3780

gcggtgctaa aactaatggc ttttcctacc taggaacaaa gaaacgccac tgtacatgca     3840

cggttcccgg cctgtggagt tgtgggagga aggcgatgtc tggccttttt tgcacagctg     3900

ctgttgcctg cccagagatc gggaactctg ccccgtagga ctggaagaaa cctcagtaat     3960

gggaataaga ctttgtccaa tagggggctg atgaatgtgt g                         4001


<210> 78
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220> 
<221> modified_base
<222> (2)..(2)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (7)..(7)
<223> 2'-OMe modified nucleotide

<220> 
<221> misc_feature
<222> (19)..(21)
<223> Phosphorothioate linkages

<220> 
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<400> 78
cuuacgcuga guacuucgau u                                                 21


<210> 79
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220> 
<221> modified_base
<222> (4)..(4)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (9)..(9)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (15)..(16)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (19)..(19)
<223> 2'-OMe modified nucleotide

<220> 
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkages

<400> 79
ggaugaagug gagauuagut t                                                 21


<210>  80
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (4)..(5)
<223>  2'F modified nucleotide

<220>
<221>  modified_base
<222>  (7)..(10)
<223>  2'F modified nucleotide

<220>
<221>  modified_base
<222>  (14)..(17)
<223>  2'F modified nucleotide

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'F modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphorothioate linkage

<400>  80
ggaucaucuc aagucuuact t                                                 21


<210> 81
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 81
ucuacuguca cucaguaguu u                                                 21


<210> 82
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220> 
<221> modified_base
<222> (2)..(2)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (7)..(7)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (9)..(9)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (14)..(14)
<223> 2'-OMe modified nucleotide

<220> 
<221> misc_feature
<222> (19)..(21)
<223> Phosphorothioate linkages

<220> 
<221> modified_base
<222> (19)..(21)
<223> 2'-OMe modified nucleotide

<400> 82
ucgaaguacu cagcguaagu u                                                 21


<210> 83
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220> 
<221> modified_base
<222> (3)..(3)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (10)..(10)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (15)..(15)
<223> 2'-OMe modified nucleotide

<220> 
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkages

<400> 83
acuaaucucc acuucaucct t                                                 21


<210>  84
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'F modified nucleotide

<220>
<221>  modified_base
<222>  (7)..(9)
<223>  2'F modified nucleotide

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'F modified nucleotide

<220>
<221>  modified_base
<222>  (17)..(19)
<223>  2'F modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphorothioate linkage

<400>  84
guaagacuug agaugaucct t                                                 21


<210> 85
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 85
gcggucauug ucacuggucu u                                                 21


<210> 86
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 86
gaccagugac aaugaccgcu u                                                 21


<210> 87
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 87
ugaaaggauu cauccuccuu u                                                 21


<210> 88
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 88
aggaggauga auccuuucau u                                                 21


<210>  89
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphorothioate linkage

<400>  89
ggaugaagug gagauuagut t                                                 21


<210>  90
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic oligonucleotide

<400>  90
acuaaucucc acuucaucct t                                                 21


<210>  91
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  modified_base
<222>  (7)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  modified_base
<222>  (14)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphorothioate linkage

<400>  91
cuuacgcuga guacuucgat t                                                 21


<210>  92
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-OMe modified nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-OMe modified nucleotide

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-OMe modified nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphorothioate linkage

<400>  92
ucgaaguacu cagcguaagt t                                                 21


<210> 93
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 93
gaccagugac aaugaccgcu u                                                 21


<210> 94
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 94
gcggucauug ucacuggucu u                                                 21


<210> 95
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 95
acuacugagu gacaguagau u                                                 21


<210> 96
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 96
ucuacuguca cucaguaguu u                                                 21


<210> 97
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 97
gcggucauug ucacuggucu u                                                 21


<210> 98
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 98
gaccagugac aaugaccgcu u                                                 21


<210> 99
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220> 
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic modification

<400> 99
gcggucauug ucacuggucu u                                                 21


<210> 100
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220> 
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic modification

<400> 100
gaccagugac aaugaccgcu u                                                 21


<210> 101
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 101
gcggucauac acacuggucu u                                                 21


<210> 102
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 102
gaccagugug uaugaccgcu u                                                 21


<210> 103
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220> 
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (5)..(5)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (7)..(8)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (12)..(12)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (14)..(17)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (20)..(21)
<223> Phosphorothioate linkage

<400> 103
cuuacgcuga guacuucgat t                                                 21


<210> 104
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220> 
<221> modified_base
<222> (7)..(7)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (11)..(11)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (16)..(16)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (20)..(21)
<223> Phosphorothioate linkage

<400> 104
ucgaaguacu cagcguaagt t                                                 21


<210> 105
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220> 
<221> modified_base
<222> (4)..(4)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (9)..(9)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (15)..(16)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (19)..(19)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (20)..(21)
<223> Phosphorothioate linkage

<400> 105
ggaugaagug gagauuagut t                                                 21


<210> 106
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220> 
<221> modified_base
<222> (3)..(3)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (10)..(10)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (15)..(15)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (20)..(21)
<223> Phosphorothioate linkage

<400> 106
acuaaucucc acuucaucct t                                                 21


<210> 107
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220> 
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic modification

<220> 
<221> modified_base
<222> (1)..(2)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (4)..(4)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (10)..(10)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (14)..(14)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<400> 107
gcggucauug ucacuggucu u                                                 21


<210> 108
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220> 
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<400> 108
gaccagugac aaugaccgcu u                                                 21


<210> 109
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220> 
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<400> 109
gaccagugac aaugaccgcu u                                                 21


<210> 110
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220> 
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic modification

<220> 
<221> modified_base
<222> (1)..(2)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (4)..(4)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (10)..(10)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (14)..(14)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<400> 110
gcggucauug ucacuggucu u                                                 21


<210>  111
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-OMe modified nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-OMe modified nucleotide

<220>
<221>  modified_base
<222>  (20)..(23)
<223>  2'-OMe modified nucleotide

<400>  111
cuuacgcuga guacuucgas usu                                               23


<210>  112
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-OMe modified nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-OMe modified nucleotide

<220>
<221>  modified_base
<222>  (15)..(16)
<223>  2'-OMe modified nucleotide

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-OMe modified nucleotide

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  Phosphorothioate linkage

<400>  112
ggaugaagug gagauuagut t                                                 21


<210>  113
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<220>
<221>  modified_base
<222>  (5)..(6)
<223>  2'F modified nucleotide

<220>
<221>  modified_base
<222>  (8)..(11)
<223>  2'F modified nucleotide

<220>
<221>  modified_base
<222>  (15)..(18)
<223>  2'F modified nucleotide

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  Phosphorothioate linkage

<400>  113
ggaucaucuc aagucuuact t                                                 21


<210>  114
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  114
ucuacuguca cucaguaguu u                                                 21


<210>  115
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-OMe modified nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-OMe modified nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-OMe modified nucleotide

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-OMe modified nucleotide

<220>
<221>  modified_base
<222>  (19)..(23)
<223>  2'-OMe modified nucleotide

<400>  115
ucgaaguacu cagcguaags usu                                               23


<210>  116
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-OMe modified nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-OMe modified nucleotide

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  Phosphorothioate linkages

<400>  116
acuaaucucc acuucaucct t                                                 21


<210>  117
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'F modified nucleotide

<220>
<221>  modified_base
<222>  (8)..(10)
<223>  2'F modified nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'F modified nucleotide

<220>
<221>  modified_base
<222>  (18)..(19)
<223>  2'F modified nucleotide

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  Phosphorothioate linkages

<400>  117
guaagacuug agaugaucct t                                                 21


<210>  118
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  118
cggucauugu cacuggucau u                                                 21


<210>  119
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  119
ugaccaguga caaugaccgu u                                                 21


<210>  120
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  120
gcggucauug ucacuggucu u                                                 21


<210>  121
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  121
gaccagugac aaugaccgcu u                                                 21


<210>  122
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  122
ugaaaggauu cauccuccuu u                                                 21


<210>  123
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  123
aggaggauga auccuuucau u                                                 21


<210>  124
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  Phosphorothioate linkages

<400>  124
ggaugaagug gagauuagut t                                                 21


<210>  125
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400>  125
acuaaucucc acuucaucct t                                                 21


<210>  126
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-OMe modified nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-OMe modified nucleotide

<220>
<221>  modified_base
<222>  (7)..(8)
<223>  2'-OMe modified nucleotide

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-OMe modified nucleotide

<220>
<221>  modified_base
<222>  (14)..(17)
<223>  2'-OMe modified nucleotide

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  Phosphorothioate linkages

<400>  126
cuuacgcuga guacuucgat t                                                 21


<210>  127
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-OMe modified nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-OMe modified nucleotide

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-OMe modified nucleotide

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  Phosphorothioate linkages

<400>  127
ucgaaguacu cagcguaagt t                                                 21


<210> 128
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220> 
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic modification

<220> 
<221> modified_base
<222> (1)..(2)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (4)..(4)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (10)..(10)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (14)..(14)
<223> 2'-OMe modified nucleotide

<220> 
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<400> 128
gcggucauug ucacuggucu u                                                 21


<210> 129
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220> 
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<400> 129
gaccagugac aaugaccgcu u                                                 21

