                         SEQUENCE LISTING

<110>  UCB Biopharma SPRL
 
<120>  Method

<130>  PF0018WO

<150>  
<151>  

<160>  38   

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1

<400>  1

Asn Tyr Gly Ile His 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2

<400>  2

Ser Ile Ser Pro Ser Gly Gly Leu Thr Tyr Tyr Arg Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH3

<400>  3

Gly Gly Glu Gly Ile Phe Asp Tyr 
1               5               


<210>  4
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CDRL1

<400>  4

Arg Ala Thr Gln Ser Ile Tyr Asn Ala Leu Ala 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CDRL2

<400>  5

Asn Ala Asn Thr Leu His Thr 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  CDRL3

<400>  6

Gln Gln Tyr Tyr Asp Tyr Pro Leu Thr 
1               5                   


<210>  7
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable region of antibody A26

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Thr Gln Ser Ile Tyr Asn Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Thr Leu His Thr Gly Val Pro Ser Arg Phe Ser Ala 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Ser Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  8
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable region of antibody A26

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Ile His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Pro Ser Gly Gly Leu Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Pro Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Glu Gly Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  9
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain of anti-OX40 antibody Fab component

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Thr Gln Ser Ile Tyr Asn Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Thr Leu His Thr Gly Val Pro Ser Arg Phe Ser Ala 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Ser Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  10
<211>  220
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain of anti-OX40 antibody Fab component

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Ile His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Pro Ser Gly Gly Leu Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Pro Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Glu Gly Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220 


<210>  11
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain of anti-albumin Fv component

<400>  11

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Asn Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Trp Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Val Pro Gly Tyr Ser Thr Ala Pro Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  12
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain of anti-albumin Fv component

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Pro Ser Val Trp Ser Asn 
            20                  25                  30          


Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Ala Ser Lys Leu Thr Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gly Gly Tyr Ser Ser Ile 
                85                  90                  95      


Ser Asp Thr Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


<210>  13
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Linker 1

<400>  13

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Thr Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  14
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Linker 2

<400>  14

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  15
<211>  357
<212>  PRT
<213>  Artificial

<220>
<223>  A26 Fab Heavy-(G4S,G4T,G4S)-645dsFv(gH5)

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Ile His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Pro Ser Gly Gly Leu Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Pro Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Glu Gly Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Thr Gly Gly Gly Gly Ser Glu Val Gln Leu 
225                 230                 235                 240 


Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                245                 250                 255     


Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Asn Tyr Ala Ile Asn Trp 
            260                 265                 270         


Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly Ile Ile Trp 
        275                 280                 285             


Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp Ala Lys Gly Arg Phe Thr 
    290                 295                 300                 


Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser 
305                 310                 315                 320 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Thr Val Pro 
                325                 330                 335     


Gly Tyr Ser Thr Ala Pro Tyr Phe Asp Leu Trp Gly Gln Gly Thr Leu 
            340                 345                 350         


Val Thr Val Ser Ser 
        355         


<210>  16
<211>  341
<212>  PRT
<213>  Artificial

<220>
<223>  A26 Fab Light-(3xG4S)-645dsFv(gL4)

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Thr Gln Ser Ile Tyr Asn Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Thr Leu His Thr Gly Val Pro Ser Arg Phe Ser Ala 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Ser Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val 
225                 230                 235                 240 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Pro 
                245                 250                 255     


Ser Val Trp Ser Asn Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys 
            260                 265                 270         


Ala Pro Lys Leu Leu Ile Tyr Glu Ala Ser Lys Leu Thr Ser Gly Val 
        275                 280                 285             


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    290                 295                 300                 


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gly 
305                 310                 315                 320 


Gly Tyr Ser Ser Ile Ser Asp Thr Thr Phe Gly Cys Gly Thr Lys Val 
                325                 330                 335     


Glu Ile Lys Arg Thr 
            340     


<210>  17
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  645gH1 heavy chain variable domain

<400>  17

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Asn Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Trp Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ser Thr Thr Val Tyr Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Thr 
                85                  90                  95      


Val Pro Gly Tyr Ser Thr Ala Pro Tyr Phe Asp Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  18
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  645gL1 light chain variable domain

<400>  18

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Pro Ser Val Trp Ser Asn 
            20                  25                  30          


Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Ala Ser Lys Leu Thr Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gly Gly Tyr Ser Ser Ile 
                85                  90                  95      


Ser Asp Thr Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  19
<211>  355
<212>  PRT
<213>  Artificial

<220>
<223>  A26 Fab Heavy-( 3xG4S)-645dsFv(gH1)

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Ile His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Pro Ser Gly Gly Leu Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Pro Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Glu Gly Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
225                 230                 235                 240 


Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                245                 250                 255     


Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Asn Tyr Ala Ile Asn Trp 
            260                 265                 270         


Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly Ile Ile Trp 
        275                 280                 285             


Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp Ala Lys Gly Arg Phe Thr 
    290                 295                 300                 


Ile Ser Arg Asp Ser Thr Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
305                 310                 315                 320 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Thr Val Pro Gly Tyr 
                325                 330                 335     


Ser Thr Ala Pro Tyr Phe Asp Leu Trp Gly Gln Gly Thr Leu Val Thr 
            340                 345                 350         


Val Ser Ser 
        355 


<210>  20
<211>  340
<212>  PRT
<213>  Artificial

<220>
<223>  A26 Fab Light-(3xG4S)-645dsFv(gL1)

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Thr Gln Ser Ile Tyr Asn Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Thr Leu His Thr Gly Val Pro Ser Arg Phe Ser Ala 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Ser Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    210                 215                 220                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser 
225                 230                 235                 240 


Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser 
                245                 250                 255     


Pro Ser Val Trp Ser Asn Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly 
            260                 265                 270         


Lys Ala Pro Lys Leu Leu Ile Tyr Glu Ala Ser Lys Leu Thr Ser Gly 
        275                 280                 285             


Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    290                 295                 300                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gly 
305                 310                 315                 320 


Gly Gly Tyr Ser Ser Ile Ser Asp Thr Thr Phe Gly Cys Gly Thr Lys 
                325                 330                 335     


Val Glu Ile Lys 
            340 


<210>  21
<211>  1137
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain A26-645(gH5) including E.coli OmpA leader

<400>  21
atgaagaaga ctgctatagc gatcgcagtg gcgctagctg gtttcgccac cgtggcgcaa       60

gctgaagttc agctggtcga gtctggaggc gggcttgtcc agcctggagg gagcctgcgt      120

ctctcttgtg cagcaagcgg tttcacgttc accaactacg gtatccactg gattcgtcag      180

gcaccaggta aaggtctgga atgggtagcc tctatctctc cgtctggtgg tctgacgtac      240

taccgtgact ctgtcaaagg tcgtttcacc atctctcgtg atgacgcgaa aaactctccg      300

tacctgcaaa tgaactctct gcgtgcagaa gataccgcag tgtactactg cgctactggt      360

ggtgaaggta tcttcgacta ctggggtcag ggtaccctgg taactgtctc gagcgcttct      420

acaaagggcc caagcgtttt cccactggct ccgtcctcta aatccacctc tggtggtacg      480

gctgcactgg gttgcctggt gaaagactac ttcccagaac cagttaccgt gtcttggaac      540

tctggtgcac tgacctctgg tgttcacacc tttccagcag ttctccagtc ttctggtctg      600

tactccctgt ctagcgtggt taccgttccg tcttcttctc tgggtactca gacctacatc      660

tgcaacgtca accacaaacc gtccaacacc aaggtcgaca aaaaagtcga gccgaaatcc      720

tgtagtggag gtgggggctc aggtggaggc gggaccggtg gaggtggcag cgaggttcaa      780

ctgcttgagt ctggaggagg cctagtccag cctggaggga gcctgcgtct ctcttgtgca      840

gtaagcggca tcgacctgag caattacgcc atcaactggg tgagacaagc tccggggaag      900

tgtttagaat ggatcggtat aatatgggcc agtgggacga ccttttatgc tacatgggcg      960

aaaggaaggt ttacaattag ccgggacaat agcaaaaaca ccgtgtatct ccaaatgaac     1020

tccttgcgag cagaggacac ggcggtgtac tattgtgctc gcactgtccc aggttatagc     1080

actgcaccct acttcgatct gtggggacaa gggaccctgg tgactgtttc aagttaa        1137


<210>  22
<211>  1074
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain A26-645(gH5)

<400>  22
gaagttcagc tggtcgagtc tggaggcggg cttgtccagc ctggagggag cctgcgtctc       60

tcttgtgcag caagcggttt cacgttcacc aactacggta tccactggat tcgtcaggca      120

ccaggtaaag gtctggaatg ggtagcctct atctctccgt ctggtggtct gacgtactac      180

cgtgactctg tcaaaggtcg tttcaccatc tctcgtgatg acgcgaaaaa ctctccgtac      240

ctgcaaatga actctctgcg tgcagaagat accgcagtgt actactgcgc tactggtggt      300

gaaggtatct tcgactactg gggtcagggt accctggtaa ctgtctcgag cgcttctaca      360

aagggcccaa gcgttttccc actggctccg tcctctaaat ccacctctgg tggtacggct      420

gcactgggtt gcctggtgaa agactacttc ccagaaccag ttaccgtgtc ttggaactct      480

ggtgcactga cctctggtgt tcacaccttt ccagcagttc tccagtcttc tggtctgtac      540

tccctgtcta gcgtggttac cgttccgtct tcttctctgg gtactcagac ctacatctgc      600

aacgtcaacc acaaaccgtc caacaccaag gtcgacaaaa aagtcgagcc gaaatcctgt      660

agtggaggtg ggggctcagg tggaggcggg accggtggag gtggcagcga ggttcaactg      720

cttgagtctg gaggaggcct agtccagcct ggagggagcc tgcgtctctc ttgtgcagta      780

agcggcatcg acctgagcaa ttacgccatc aactgggtga gacaagctcc ggggaagtgt      840

ttagaatgga tcggtataat atgggccagt gggacgacct tttatgctac atgggcgaaa      900

ggaaggttta caattagccg ggacaatagc aaaaacaccg tgtatctcca aatgaactcc      960

ttgcgagcag aggacacggc ggtgtactat tgtgctcgca ctgtcccagg ttatagcact     1020

gcaccctact tcgatctgtg gggacaaggg accctggtga ctgtttcaag ttaa           1074


<210>  23
<211>  1089
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain A26-645(gL4) including E.coli OmpA leader

<400>  23
atgaaaaaga cagctatcgc aattgcagtg gcgttggctg gtttcgcgac cgttgcgcaa       60

gctgatatcc agatgaccca gagcccaagc agtctctccg ccagcgtagg cgatcgtgtg      120

actattacct gtcgtgcaac ccagagcatc tacaacgctc tggcttggta tcagcagaaa      180

ccgggtaaag cgccaaaact cctgatctac aacgcgaaca ctctgcatac tggtgttccg      240

tctcgtttct ctgcgtctgg ttctggtacg gactctactc tgaccatctc ctctctccag      300

ccggaagatt tcgcgaccta ctactgccag cagtactacg attacccact gacgtttggt      360

ggtggtacca aagttgagat caaacgtacg gttgcagctc catccgtctt catctttcca      420

ccgtctgacg aacagctcaa atctggtact gcttctgtcg tttgcctcct gaacaacttc      480

tatccgcgtg aagcgaaagt ccagtggaaa gtcgacaacg cactccagtc tggtaactct      540

caggaatctg tgaccgaaca ggactccaaa gactccacct actctctgtc tagcaccctg      600

actctgtcca aagcagacta cgagaaacac aaagtgtacg cttgcgaagt tacccatcag      660

ggtctgagct ctccggttac caaatccttt aatagagggg agtgtggtgg cggtggcagt      720

ggtggtggag gttccggagg tggcggttca gacatacaaa tgacccagag tccttcatcg      780

gtatccgcgt ccgttggcga tagggtgact attacatgtc aaagctctcc tagcgtctgg      840

agcaattttc tatcctggta tcaacagaaa ccggggaagg ctccaaaact tctgatttat      900

gaagcctcga aactcaccag tggagttccg tcaagattca gtggctctgg atcagggaca      960

gacttcacgt tgacaatcag ttcgctgcaa ccagaggact ttgcgaccta ctattgtggt     1020

ggaggttaca gtagcataag tgatacgaca tttgggtgcg gtactaaggt ggaaatcaaa     1080

cgtacctaa                                                             1089


<210>  24
<211>  1026
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain A26-645(gL4)

<400>  24
gatatccaga tgacccagag cccaagcagt ctctccgcca gcgtaggcga tcgtgtgact       60

attacctgtc gtgcaaccca gagcatctac aacgctctgg cttggtatca gcagaaaccg      120

ggtaaagcgc caaaactcct gatctacaac gcgaacactc tgcatactgg tgttccgtct      180

cgtttctctg cgtctggttc tggtacggac tctactctga ccatctcctc tctccagccg      240

gaagatttcg cgacctacta ctgccagcag tactacgatt acccactgac gtttggtggt      300

ggtaccaaag ttgagatcaa acgtacggtt gcagctccat ccgtcttcat ctttccaccg      360

tctgacgaac agctcaaatc tggtactgct tctgtcgttt gcctcctgaa caacttctat      420

ccgcgtgaag cgaaagtcca gtggaaagtc gacaacgcac tccagtctgg taactctcag      480

gaatctgtga ccgaacagga ctccaaagac tccacctact ctctgtctag caccctgact      540

ctgtccaaag cagactacga gaaacacaaa gtgtacgctt gcgaagttac ccatcagggt      600

ctgagctctc cggttaccaa atcctttaat agaggggagt gtggtggcgg tggcagtggt      660

ggtggaggtt ccggaggtgg cggttcagac atacaaatga cccagagtcc ttcatcggta      720

tccgcgtccg ttggcgatag ggtgactatt acatgtcaaa gctctcctag cgtctggagc      780

aattttctat cctggtatca acagaaaccg gggaaggctc caaaacttct gatttatgaa      840

gcctcgaaac tcaccagtgg agttccgtca agattcagtg gctctggatc agggacagac      900

ttcacgttga caatcagttc gctgcaacca gaggactttg cgacctacta ttgtggtgga      960

ggttacagta gcataagtga tacgacattt gggtgcggta ctaaggtgga aatcaaacgt     1020

acctaa                                                                1026


<210>  25
<211>  1131
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain A26-645(gH5) including B72.3 leader sequence

<400>  25
atggaatggt cctgggtctt cctgtttttc ctttctgtca caaccggggt gcacagcgag       60

gtgcagctcg tcgagtctgg aggcgggctt gtccagcctg gagggagcct gcgtctctct      120

tgtgcagcaa gcggtttcac gttcaccaac tacggtatcc actggattcg tcaggcacca      180

ggtaaaggtc tggaatgggt agcctctatc tctccgtctg gtggtctgac gtactaccgt      240

gactctgtca aaggtcgttt caccatctct cgtgatgacg cgaaaaactc tccgtacctg      300

cagatgaact ctctgcgtgc agaagatacc gcagtgtact actgcgctac tggtggtgaa      360

ggtatcttcg actactgggg tcagggtacc ctggtaactg tctcaagcgc ttctacaaag      420

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      480

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      540

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctctgg actctactcc      600

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      660

gtgaatcaca agcccagcaa caccaaggtg gacaagaaag ttgagcccaa atcttgttcc      720

ggaggtggcg gttccggagg tggcggtacc ggtggcggtg gatccgaagt ccagctgctt      780

gaatccggag gcggactcgt gcagcccgga ggcagtcttc gcttgtcctg cgctgtatct      840

ggaatcgacc tgagcaatta cgccatcaac tgggtgagac aggcacctgg gaaatgcctc      900

gaatggatcg gcattatatg ggctagtggg acgacctttt atgctacatg ggcgaagggt      960

agattcacaa tctcacggga taatagtaag aacacagtgt acctgcagat gaactccctg     1020

cgagcagagg ataccgccgt ttactattgt gctcgcactg tcccaggtta tagcactgca     1080

ccctactttg atctgtgggg gcagggcact ctggtcaccg tctcgagttg a              1131


<210>  26
<211>  1074
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain A26-645(gH5)

<400>  26
gaggtgcagc tcgtcgagtc tggaggcggg cttgtccagc ctggagggag cctgcgtctc       60

tcttgtgcag caagcggttt cacgttcacc aactacggta tccactggat tcgtcaggca      120

ccaggtaaag gtctggaatg ggtagcctct atctctccgt ctggtggtct gacgtactac      180

cgtgactctg tcaaaggtcg tttcaccatc tctcgtgatg acgcgaaaaa ctctccgtac      240

ctgcagatga actctctgcg tgcagaagat accgcagtgt actactgcgc tactggtggt      300

gaaggtatct tcgactactg gggtcagggt accctggtaa ctgtctcaag cgcttctaca      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc tggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      660

tccggaggtg gcggttccgg aggtggcggt accggtggcg gtggatccga agtccagctg      720

cttgaatccg gaggcggact cgtgcagccc ggaggcagtc ttcgcttgtc ctgcgctgta      780

tctggaatcg acctgagcaa ttacgccatc aactgggtga gacaggcacc tgggaaatgc      840

ctcgaatgga tcggcattat atgggctagt gggacgacct tttatgctac atgggcgaag      900

ggtagattca caatctcacg ggataatagt aagaacacag tgtacctgca gatgaactcc      960

ctgcgagcag aggataccgc cgtttactat tgtgctcgca ctgtcccagg ttatagcact     1020

gcaccctact ttgatctgtg ggggcagggc actctggtca ccgtctcgag ttga           1074


<210>  27
<211>  1086
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain A26-645(gL4) including B72.3 leader sequence

<400>  27
atgtcagttc ccacacaggt gctgggcctg cttctgttgt ggctcaccga tgctaggtgt       60

gatatccaga tgacccagag tccaagcagt ctctccgcca gcgtaggcga tcgtgtgact      120

attacctgtc gtgcaaccca gagcatctac aacgctctgg cttggtatca gcagaaaccg      180

ggtaaagcgc caaaactcct gatctacaac gcgaacactc tgcataccgg tgttccgtct      240

cgtttctctg cgtctggttc tggtacggac tctactctga ccatctcctc tctgcagccg      300

gaagatttcg cgacctacta ctgccagcag tactacgatt acccactgac gtttggtggt      360

ggtaccaaag ttgagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccccca      420

tctgatgagc agttgaagtc tggcactgcc tctgttgtgt gcctgctgaa taacttctac      480

cctagagagg ccaaagtcca gtggaaggtg gataacgccc ttcaatccgg aaactcccag      540

gagagtgtca ctgagcagga ctcaaaggac tccacctata gccttagcag cacactgaca      600

ctgagcaagg ctgactacga gaaacacaag gtctacgcct gcgaagtgac acatcaaggc      660

ctgagctcac ccgtgacaaa gagctttaac aggggagagt gtggtggagg tggctctggc      720

ggtggtggct ccggaggcgg aggaagcgac atccagatga cccagagccc ttcctctgta      780

agcgccagtg tcggagacag agtgactatt acctgccaaa gctccccttc agtctggtcc      840

aattttctat cctggtacca gcaaaagccc ggaaaggctc ctaaattgct gatctacgaa      900

gcaagcaaac tcaccagcgg cgtgcccagc aggttcagcg gcagtgggtc tggaactgac      960

tttaccctga caatctcctc actccagccc gaggacttcg ccacctatta ctgcggtgga     1020

ggttacagta gcataagtga tacgacattt ggatgcggca ctaaagtgga aatcaagcgt     1080

acctga                                                                1086


<210>  28
<211>  1026
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain A26-645(gL4)

<400>  28
gatatccaga tgacccagag tccaagcagt ctctccgcca gcgtaggcga tcgtgtgact       60

attacctgtc gtgcaaccca gagcatctac aacgctctgg cttggtatca gcagaaaccg      120

ggtaaagcgc caaaactcct gatctacaac gcgaacactc tgcataccgg tgttccgtct      180

cgtttctctg cgtctggttc tggtacggac tctactctga ccatctcctc tctgcagccg      240

gaagatttcg cgacctacta ctgccagcag tactacgatt acccactgac gtttggtggt      300

ggtaccaaag ttgagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccccca      360

tctgatgagc agttgaagtc tggcactgcc tctgttgtgt gcctgctgaa taacttctac      420

cctagagagg ccaaagtcca gtggaaggtg gataacgccc ttcaatccgg aaactcccag      480

gagagtgtca ctgagcagga ctcaaaggac tccacctata gccttagcag cacactgaca      540

ctgagcaagg ctgactacga gaaacacaag gtctacgcct gcgaagtgac acatcaaggc      600

ctgagctcac ccgtgacaaa gagctttaac aggggagagt gtggtggagg tggctctggc      660

ggtggtggct ccggaggcgg aggaagcgac atccagatga cccagagccc ttcctctgta      720

agcgccagtg tcggagacag agtgactatt acctgccaaa gctccccttc agtctggtcc      780

aattttctat cctggtacca gcaaaagccc ggaaaggctc ctaaattgct gatctacgaa      840

gcaagcaaac tcaccagcgg cgtgcccagc aggttcagcg gcagtgggtc tggaactgac      900

tttaccctga caatctcctc actccagccc gaggacttcg ccacctatta ctgcggtgga      960

ggttacagta gcataagtga tacgacattt ggatgcggca ctaaagtgga aatcaagcgt     1020

acctga                                                                1026


<210>  29
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of anti-albumin antibody (no ds)

<400>  1

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Asn Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Trp Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Val Pro Gly Tyr Ser Thr Ala Pro Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  30
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of anti-albumin antibody (ds)

<400>  2

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Asn Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Trp Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Val Pro Gly Tyr Ser Thr Ala Pro Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  31
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of anti-albumin antibody (no ds)

<400>  3

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Pro Ser Val Trp Ser Asn 
            20                  25                  30          


Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Ala Ser Lys Leu Thr Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gly Gly Tyr Ser Ser Ile 
                85                  90                  95      


Ser Asp Thr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


<210>  32
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of anti-albumin antibody (ds)

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Pro Ser Val Trp Ser Asn 
            20                  25                  30          


Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Ala Ser Lys Leu Thr Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gly Gly Tyr Ser Ser Ile 
                85                  90                  95      


Ser Asp Thr Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


<210>  33
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Linker 1

<400>  5

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Thr Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  34
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Linker 2

<400>  6

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  

        
<210>  35
<211>  789
<212>  DNA
<213>  Artificial

<220>
<223>  645 gH5gL4

<400>  13
gaggttcagc tgctggagtc tggaggcggg cttgtccagc ctggagggag cctgcgtctc       60

tcttgtgcag taagcggcat cgacctgtcc aactacgcga ttaactgggt acgtcaggca      120

ccgggtaaag gtctggaatg gatcggcatc atctgggcct ctggtacgac cttctacgct      180

acttgggcca aaggtcgttt caccatctcc cgtgacaact ctaaaaacac cgtgtacctg      240

cagatgaact ctctgcgtgc ggaagacact gcggtttact attgcgcgcg taccgttccg      300

ggctattcta ctgcaccgta cttcgacctg tggggtcagg gtactctggt taccgtctcg      360

agtggaggtg gcggttctgg cggtggcggt tccggtggcg gtggatcggg aggtggcggt      420

tctgatatcc agatgaccca gagtccaagc agtgtttccg ccagcgtagg cgatcgtgtg      480

actattacct gtcagtcctc tccgagcgtt tggtccaact tcctgagctg gtaccagcag      540

aaaccgggta aagccccgaa actgctgatc tacgaggcgt ctaaactgac ctctggtgta      600

ccgtcccgtt tctctggctc tggctctggt acggacttca ctctgaccat ctcctctctg      660

cagccggaag actttgcaac gtactactgc ggtggtggtt actcttccat ctctgacacc      720

acgttcggtg gaggcaccaa agttgaaatc aaacgtacgc atcaccatca ccatcaccat      780

caccatcac                                                              789


<210>  36
<211>  263
<212>  PRT
<213>  Artificial

<220>
<223>  645 gH5gL4

<400>  14

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Asn Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Trp Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Val Pro Gly Tyr Ser Thr Ala Pro Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Gln Ser Ser Pro Ser Val Trp Ser Asn Phe Leu Ser 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Glu 
            180                 185                 190         


Ala Ser Lys Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
    210                 215                 220                 


Phe Ala Thr Tyr Tyr Cys Gly Gly Gly Tyr Ser Ser Ile Ser Asp Thr 
225                 230                 235                 240 


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr His His His 
                245                 250                 255     


His His His His His His His 
            260             


<210>  37
<211>  789
<212>  DNA
<213>  Artificial

<220>
<223>  645 gH5gL4ds

<400>  15
gaggttcagc tgctggagtc tggaggcggg cttgtccagc ctggagggag cctgcgtctc       60

tcttgtgcag taagcggcat cgacctgtcc aactacgcga ttaactgggt acgtcaggca      120

ccgggtaaat gcctggaatg gatcggcatc atctgggcct ctggtacgac cttctacgct      180

acttgggcca aaggtcgttt caccatctcc cgtgacaact ctaaaaacac cgtgtacctg      240

cagatgaact ctctgcgtgc ggaagacact gcggtttact attgcgcgcg taccgttccg      300

ggctattcta ctgcaccgta cttcgacctg tggggtcagg gtactctggt taccgtctcg      360

agtggaggtg gcggttctgg cggtggcggt tccggtggcg gtggatcggg aggtggcggt      420

tctgatatcc agatgaccca gagtccaagc agtgtttccg ccagcgtagg cgatcgtgtg      480

actattacct gtcagtcctc tccgagcgtt tggtccaact tcctgagctg gtaccagcag      540

aaaccgggta aagccccgaa actgctgatc tacgaggcgt ctaaactgac ctctggtgta      600

ccgtcccgtt tctctggctc tggctctggt acggacttca ctctgaccat ctcctctctg      660

cagccggaag actttgcaac gtactactgc ggtggtggtt actcttccat ctctgacacc      720

acgttcggtt gtggcaccaa agttgaaatc aaacgtacgc atcaccatca ccatcaccat      780

caccatcac                                                              789


<210>  38
<211>  263
<212>  PRT
<213>  Artificial

<220>
<223>  645 gH5gL4ds

<400>  16

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Asn Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Trp Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Val Pro Gly Tyr Ser Thr Ala Pro Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Gln Ser Ser Pro Ser Val Trp Ser Asn Phe Leu Ser 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Glu 
            180                 185                 190         


Ala Ser Lys Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
    210                 215                 220                 


Phe Ala Thr Tyr Tyr Cys Gly Gly Gly Tyr Ser Ser Ile Ser Asp Thr 
225                 230                 235                 240 


Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Arg Thr His His His 
                245                 250                 255     


His His His His His His His 
            260             

