                         SEQUENCE LISTING

<110>  The California Institute for Biomedical Research
       Kim, Chanhyuk
       Young, Travis
       Ma, Jennifer
       Kim, Ji Young
       Wang, Xinxin
       Laborda, Eduardo
       Peter, Schultz G.
 
<120>  OPTIMIZED CHIMERIC RECEPTOR T CELL SWITCHES AND USES THEREOF

<130>  CIBR-009/02WO  323414-2036

<150>  US 62/148,070
<151>  2015-04-15

<150>  US 62/253,465
<151>  2015-11-10

<160>  53    

<170>  PatentIn version 3.5

<210>  1
<211>  8892
<212>  DNA
<213>  Artificial Sequene

<220>
<223>  Made in lab - LV-EF1a-4-4-20-BBZ chimerica antigen receptor 
       polynucleotide

<400>  1
caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac       60

attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa      120

aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat      180

tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc      240

agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga      300

gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg      360

cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc      420

agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag      480

taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc      540

tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg      600

taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg      660

acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac      720

ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac      780

cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg      840

agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg      900

tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg      960

agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac     1020

tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg     1080

ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg     1140

tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc     1200

aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc     1260

tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtc cttctagtgt     1320

agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc     1380

taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact     1440

caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac     1500

agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag     1560

aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg     1620

gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg     1680

tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga     1740

gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt     1800

ttgctcacat gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct     1860

ttgagtgagc tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg     1920

aggaagcgga agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt     1980

aatgcagctg gcacgacagg tttcccgact ggaaagcggg cagtgagcgc aacgcaatta     2040

atgtgagtta gctcactcat taggcacccc aggctttaca ctttatgctt ccggctcgta     2100

tgttgtgtgg aattgtgagc ggataacaat ttcacacagg aaacagctat gaccatgatt     2160

acgccaagcg cgcaattaac cctcactaaa gggaacaaaa gctggagctg caagcttaat     2220

gtagtcttat gcaatactct tgtagtcttg caacatggta acgatgagtt agcaacatgc     2280

cttacaagga gagaaaaagc accgtgcatg ccgattggtg gaagtaaggt ggtacgatcg     2340

tgccttatta ggaaggcaac agacgggtct gacatggatt ggacgaacca ctgaattgcc     2400

gcattgcaga gatattgtat ttaagtgcct agctcgatac aataaacggg tctctctggt     2460

tagaccagat ctgagcctgg gagctctctg gctaactagg gaacccactg cttaagcctc     2520

aataaagctt gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt gactctggta     2580

actagagatc cctcagaccc ttttagtcag tgtggaaaat ctctagcagt ggcgcccgaa     2640

cagggacctg aaagcgaaag ggaaaccaga gctctctcga cgcaggactc ggcttgctga     2700

agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa ttttgactag     2760

cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg ggagaattag     2820

atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata aattaaaaca     2880

tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc tgttagaaac     2940

atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga caggatcaga     3000

agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc aaaggataga     3060

gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca aaagtaagac     3120

caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg agggacaatt     3180

ggagaagtga attatataaa tataaagtag taaaaattga accattagga gtagcaccca     3240

ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata ggagctttgt     3300

tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcctcaatg acgctgacgg     3360

tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg ctgagggcta     3420

ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag ctccaggcaa     3480

gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt tggggttgct     3540

ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt aataaatctc     3600

tggaacagat tggaatcaca cgacctggat ggagtgggac agagaaatta acaattacac     3660

aagcttaata cactccttaa ttgaagaatc gcaaaaccag caagaaaaga atgaacaaga     3720

attattggaa ttagataaat gggcaagttt gtggaattgg tttaacataa caaattggct     3780

gtggtatata aaattattca taatgatagt aggaggcttg gtaggtttaa gaatagtttt     3840

tgctgtactt tctatagtga atagagttag gcagggatat tcaccattat cgtttcagac     3900

ccacctccca accccgaggg gacccgacag gcccgaagga atagaagaag aaggtggaga     3960

gagagacaga gacagatcca ttcgattagt gaacggatct cgacggttaa cttttaaaag     4020

aaaagggggg attggggggt acagtgcagg ggaaagaata gtagacataa tagcaacaga     4080

catacaaact aaagaattac aaaaacaaat tacaaaaatt caaaatttta tcgagctttg     4140

caaagatgga taaagtttta aacagagagg aatctttgca gctaatggac cttctaggtc     4200

ttgaaaggag tgcctcgtga ggctccggtg cccgtcagtg ggcagagcgc acatcgccca     4260

cagtccccga gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc     4320

gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg     4380

gagaaccgta tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg     4440

ccagaacaca ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg     4500

gcccttgcgt gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc     4560

ttcgggttgg aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc     4620

gtgcttgagt tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc     4680

ttcgcgcctg tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg     4740

ctgcgacgct ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg     4800

gtatttcggt ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt     4860

cggcgaggcg gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg     4920

gccggcctgc tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa     4980

ggctggcccg gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg     5040

cagggagctc aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac     5100

aaaggaaaag ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg     5160

cgccgtccag gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg     5220

gggaggggtt ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc     5280

cagcttggca cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt     5340

tcattctcaa gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag     5400

gaattcggta ccgcggccgc ccggggatcc atggccttac cagtgaccgc cttgctcctg     5460

ccgctggcct tgctgctcca cgccgccagg ccggatgttg ttatgaccca gaccccgctg     5520

tccctgcccg tttccctggg tgaccaggcg agtatctctt gccgttcctc tcagtccctg     5580

gttcacagtc agggtaacac ctatctgcgc tggtatctgc aaaaaccagg ccagagccct     5640

aaagtgctga tttataaggt ttcaaatcgg tttagcggcg tcccggatcg cttctctggg     5700

agtggatcag ggaccgactt tacactgaaa attagccgcg tggaagcaga ggatctgggc     5760

gtgtactttt gcagccagtc cactcatgtg ccgtggacct tcggcggtgg gacaaaactg     5820

gaaattaagc gtgcaggagg cggtgggagc ggaggcggtg ggtccggagg cggtgggtct     5880

ggaggcggtg ggagtggagg cggtgggtca ggcggtggtg ggagcgaagt gaaactggat     5940

gagacaggag gaggtctggt tcagccaggt cggcccatga agctgtcctg tgtggcctct     6000

ggctttacct tctccgacta ttggatgaac tgggtccgtc agtctccgga aaaaggtctg     6060

gagtgggtgg cgcagattcg gaacaagccc tacaactacg aaacttacta ctctgatagt     6120

gttaaaggcc gcttcaccat cagtcgtgat gactcaaaaa gcagcgttta cctgcaaatg     6180

aacaatctgc gtgtcgagga catgggcatc tattactgca caggctccta ctatgggatg     6240

gattattggg ggcaggggac ttcagttaca gtttcctcaa ccacgacgcc agcgccgcga     6300

ccaccaacac cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc     6360

cggccagcgg cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatatctac     6420

atctgggcgc ccttggccgg gacttgtggg gtccttctcc tgtcactggt tatcaccctt     6480

tactgcaaac ggggcagaaa gaaactcctg tatatattca aacaaccatt tatgagacca     6540

gtacaaacta ctcaagagga agatggctgt agctgccgat ttccagaaga agaagaagga     6600

ggatgtgaac tgagagtgaa gttcagcagg agcgcagacg cccccgcgta caagcagggc     6660

cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga tgttttggac     6720

aagagacgtg gccgggaccc tgagatgggg ggaaagccga gaaggaagaa ccctcaggaa     6780

ggcctgtaca atgaactgca gaaagataag atggcggagg cctacagtga gattgggatg     6840

aaaggcgagc gccggagggg caaggggcac gatggccttt accagggtct cagtacagcc     6900

accaaggaca cctacgacgc ccttcacatg caggccctgc cccctcgcta agtcgacaat     6960

caacctctgg attacaaaat ttgtgaaaga ttgactggta ttcttaacta tgttgctcct     7020

tttacgctat gtggatacgc tgctttaatg cctttgtatc atgctattgc ttcccgtatg     7080

gctttcattt tctcctcctt gtataaatcc tggttgctgt ctctttatga ggagttgtgg     7140

cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg ctgacgcaac ccccactggt     7200

tggggcattg ccaccacctg tcagctcctt tccgggactt tcgctttccc cctccctatt     7260

gccacggcgg aactcatcgc cgcctgcctt gcccgctgct ggacaggggc tcggctgttg     7320

ggcactgaca attccgtggt gttgtcgggg aagctgacgt cctttccatg gctgctcgcc     7380

tgtgttgcca cctggattct gcgcgggacg tccttctgct acgtcccttc ggccctcaat     7440

ccagcggacc ttccttcccg cggcctgctg ccggctctgc ggcctcttcc gcgtcttcgc     7500

cttcgccctc agacgagtcg gatctccctt tgggccgcct ccccgcctgg aattcgagct     7560

cggtaccttt aagaccaatg acttacaagg cagctgtaga tcttagccac tttttaaaag     7620

aaaagggggg actggaaggg ctaattcact cccaacgaag acaagatctg ctttttgctt     7680

gtactgggtc tctctggtta gaccagatct gagcctggga gctctctggc taactaggga     7740

acccactgct taagcctcaa taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc     7800

tgttgtgtga ctctggtaac tagagatccc tcagaccctt ttagtcagtg tggaaaatct     7860

ctagcagtag tagttcatgt catcttatta ttcagtattt ataacttgca aagaaatgaa     7920

tatcagagag tgagaggaac ttgtttattg cagcttataa tggttacaaa taaagcaata     7980

gcatcacaaa tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca     8040

aactcatcaa tgtatcttat catgtctggc tctagctatc ccgcccctaa ctccgcccag     8100

ttccgcccat tctccgcccc atggctgact aatttttttt atttatgcag aggccgaggc     8160

cgcctcggcc tctgagctat tccagaagta gtgaggaggc ttttttggag gcctaggctt     8220

ttgcgtcgag acgtacccaa ttcgccctat agtgagtcgt attacgcgcg ctcactggcc     8280

gtcgttttac aacgtcgtga ctgggaaaac cctggcgtta cccaacttaa tcgccttgca     8340

gcacatcccc ctttcgccag ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc     8400

caacagttgc gcagcctgaa tggcgaatgg cgcgacgcgc cctgtagcgg cgcattaagc     8460

gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc     8520

gctcctttcg ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct     8580

ctaaatcggg ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa     8640

aaacttgatt agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc     8700

cctttgacgt tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca     8760

ctcaacccta tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat     8820

tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg     8880

tttacaattt cc                                                         8892


<210>  2
<211>  8892
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in lab - LV-EF1a-4D5Flu-BBZ chimeric antigen receptor 
       polynucleotide

<400>  2
caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac       60

attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa      120

aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat      180

tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc      240

agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga      300

gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg      360

cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc      420

agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag      480

taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc      540

tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg      600

taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg      660

acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac      720

ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac      780

cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg      840

agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg      900

tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg      960

agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac     1020

tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg     1080

ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg     1140

tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc     1200

aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc     1260

tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtc cttctagtgt     1320

agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc     1380

taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact     1440

caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac     1500

agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag     1560

aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg     1620

gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg     1680

tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga     1740

gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt     1800

ttgctcacat gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct     1860

ttgagtgagc tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg     1920

aggaagcgga agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt     1980

aatgcagctg gcacgacagg tttcccgact ggaaagcggg cagtgagcgc aacgcaatta     2040

atgtgagtta gctcactcat taggcacccc aggctttaca ctttatgctt ccggctcgta     2100

tgttgtgtgg aattgtgagc ggataacaat ttcacacagg aaacagctat gaccatgatt     2160

acgccaagcg cgcaattaac cctcactaaa gggaacaaaa gctggagctg caagcttaat     2220

gtagtcttat gcaatactct tgtagtcttg caacatggta acgatgagtt agcaacatgc     2280

cttacaagga gagaaaaagc accgtgcatg ccgattggtg gaagtaaggt ggtacgatcg     2340

tgccttatta ggaaggcaac agacgggtct gacatggatt ggacgaacca ctgaattgcc     2400

gcattgcaga gatattgtat ttaagtgcct agctcgatac aataaacggg tctctctggt     2460

tagaccagat ctgagcctgg gagctctctg gctaactagg gaacccactg cttaagcctc     2520

aataaagctt gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt gactctggta     2580

actagagatc cctcagaccc ttttagtcag tgtggaaaat ctctagcagt ggcgcccgaa     2640

cagggacctg aaagcgaaag ggaaaccaga gctctctcga cgcaggactc ggcttgctga     2700

agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa ttttgactag     2760

cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg ggagaattag     2820

atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata aattaaaaca     2880

tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc tgttagaaac     2940

atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga caggatcaga     3000

agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc aaaggataga     3060

gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca aaagtaagac     3120

caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg agggacaatt     3180

ggagaagtga attatataaa tataaagtag taaaaattga accattagga gtagcaccca     3240

ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata ggagctttgt     3300

tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcctcaatg acgctgacgg     3360

tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg ctgagggcta     3420

ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag ctccaggcaa     3480

gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt tggggttgct     3540

ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt aataaatctc     3600

tggaacagat tggaatcaca cgacctggat ggagtgggac agagaaatta acaattacac     3660

aagcttaata cactccttaa ttgaagaatc gcaaaaccag caagaaaaga atgaacaaga     3720

attattggaa ttagataaat gggcaagttt gtggaattgg tttaacataa caaattggct     3780

gtggtatata aaattattca taatgatagt aggaggcttg gtaggtttaa gaatagtttt     3840

tgctgtactt tctatagtga atagagttag gcagggatat tcaccattat cgtttcagac     3900

ccacctccca accccgaggg gacccgacag gcccgaagga atagaagaag aaggtggaga     3960

gagagacaga gacagatcca ttcgattagt gaacggatct cgacggttaa cttttaaaag     4020

aaaagggggg attggggggt acagtgcagg ggaaagaata gtagacataa tagcaacaga     4080

catacaaact aaagaattac aaaaacaaat tacaaaaatt caaaatttta tcgagctttg     4140

caaagatgga taaagtttta aacagagagg aatctttgca gctaatggac cttctaggtc     4200

ttgaaaggag tgcctcgtga ggctccggtg cccgtcagtg ggcagagcgc acatcgccca     4260

cagtccccga gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc     4320

gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg     4380

gagaaccgta tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg     4440

ccagaacaca ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg     4500

gcccttgcgt gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc     4560

ttcgggttgg aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc     4620

gtgcttgagt tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc     4680

ttcgcgcctg tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg     4740

ctgcgacgct ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg     4800

gtatttcggt ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt     4860

cggcgaggcg gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg     4920

gccggcctgc tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa     4980

ggctggcccg gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg     5040

cagggagctc aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac     5100

aaaggaaaag ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg     5160

cgccgtccag gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg     5220

gggaggggtt ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc     5280

cagcttggca cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt     5340

tcattctcaa gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag     5400

gaattcggta ccgcggccgc ccggggatcc atggccttac cagtgaccgc cttgctcctg     5460

ccgctggcct tgctgctcca cgccgccagg ccggacattc agatgactca gagcccgtct     5520

tccctgtccg cttcagtggg tgaccgtgtt accattacct gccgtgcttc tcagagcctg     5580

gtgcactccc agggtaacac ctatctgcgg tggtatcagc agaaaccggg caaggccccc     5640

aaagttctga tttataaggt ctctaatcgg tttagtggcg ttccgtcacg cttctcaggt     5700

agcgggtccg gaacagattt taccctgaca attagcagcc tgcaaccgga agacttcgca     5760

acctattact gccagcagtc tacccatgtg ccctggacat ttggccaggg tactaaggtt     5820

gagctgaaac gtgctggagg tggaggaagc ggaggtggag gcagcggcgg tgggggatct     5880

ggcggtgggg gaagtggcgg tgggggatca ggcggtgggg gaagcgaagt ccagctggtg     5940

gagagtggag gtggactggt gcagccagga ggcagcctgc gtctgtcctg tgccgcgtct     6000

ggctttacct tcagcgatta ctggatgaac tgggtccgtc aggcaccagg aaagggcctg     6060

gaatgggtgg cgcagattcg gaacaagcct tacaactacg agacttacta cgcggatagc     6120

gtgaagggtc gcttcaccat cagtcgtgac acatcaaaga acactgttta cctgcaaatg     6180

aacagcctgc gtgcagaaga taccgctgtc tattactgca caggctctta ttacggcatg     6240

gactactggg gccagggtac tctggtgacc gtttctagta ccacgacgcc agcgccgcga     6300

ccaccaacac cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc     6360

cggccagcgg cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatatctac     6420

atctgggcgc ccttggccgg gacttgtggg gtccttctcc tgtcactggt tatcaccctt     6480

tactgcaaac ggggcagaaa gaaactcctg tatatattca aacaaccatt tatgagacca     6540

gtacaaacta ctcaagagga agatggctgt agctgccgat ttccagaaga agaagaagga     6600

ggatgtgaac tgagagtgaa gttcagcagg agcgcagacg cccccgcgta caagcagggc     6660

cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga tgttttggac     6720

aagagacgtg gccgggaccc tgagatgggg ggaaagccga gaaggaagaa ccctcaggaa     6780

ggcctgtaca atgaactgca gaaagataag atggcggagg cctacagtga gattgggatg     6840

aaaggcgagc gccggagggg caaggggcac gatggccttt accagggtct cagtacagcc     6900

accaaggaca cctacgacgc ccttcacatg caggccctgc cccctcgcta agtcgacaat     6960

caacctctgg attacaaaat ttgtgaaaga ttgactggta ttcttaacta tgttgctcct     7020

tttacgctat gtggatacgc tgctttaatg cctttgtatc atgctattgc ttcccgtatg     7080

gctttcattt tctcctcctt gtataaatcc tggttgctgt ctctttatga ggagttgtgg     7140

cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg ctgacgcaac ccccactggt     7200

tggggcattg ccaccacctg tcagctcctt tccgggactt tcgctttccc cctccctatt     7260

gccacggcgg aactcatcgc cgcctgcctt gcccgctgct ggacaggggc tcggctgttg     7320

ggcactgaca attccgtggt gttgtcgggg aagctgacgt cctttccatg gctgctcgcc     7380

tgtgttgcca cctggattct gcgcgggacg tccttctgct acgtcccttc ggccctcaat     7440

ccagcggacc ttccttcccg cggcctgctg ccggctctgc ggcctcttcc gcgtcttcgc     7500

cttcgccctc agacgagtcg gatctccctt tgggccgcct ccccgcctgg aattcgagct     7560

cggtaccttt aagaccaatg acttacaagg cagctgtaga tcttagccac tttttaaaag     7620

aaaagggggg actggaaggg ctaattcact cccaacgaag acaagatctg ctttttgctt     7680

gtactgggtc tctctggtta gaccagatct gagcctggga gctctctggc taactaggga     7740

acccactgct taagcctcaa taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc     7800

tgttgtgtga ctctggtaac tagagatccc tcagaccctt ttagtcagtg tggaaaatct     7860

ctagcagtag tagttcatgt catcttatta ttcagtattt ataacttgca aagaaatgaa     7920

tatcagagag tgagaggaac ttgtttattg cagcttataa tggttacaaa taaagcaata     7980

gcatcacaaa tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca     8040

aactcatcaa tgtatcttat catgtctggc tctagctatc ccgcccctaa ctccgcccag     8100

ttccgcccat tctccgcccc atggctgact aatttttttt atttatgcag aggccgaggc     8160

cgcctcggcc tctgagctat tccagaagta gtgaggaggc ttttttggag gcctaggctt     8220

ttgcgtcgag acgtacccaa ttcgccctat agtgagtcgt attacgcgcg ctcactggcc     8280

gtcgttttac aacgtcgtga ctgggaaaac cctggcgtta cccaacttaa tcgccttgca     8340

gcacatcccc ctttcgccag ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc     8400

caacagttgc gcagcctgaa tggcgaatgg cgcgacgcgc cctgtagcgg cgcattaagc     8460

gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc     8520

gctcctttcg ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct     8580

ctaaatcggg ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa     8640

aaacttgatt agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc     8700

cctttgacgt tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca     8760

ctcaacccta tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat     8820

tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg     8880

tttacaattt cc                                                         8892


<210>  3
<211>  8868
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in lab - LV-EF1a-4M5.3-BBZ chimeric antigen receptor 
       polynucleotide

<400>  3
caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac       60

attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa      120

aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat      180

tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc      240

agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga      300

gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg      360

cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc      420

agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag      480

taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc      540

tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg      600

taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg      660

acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac      720

ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac      780

cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg      840

agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg      900

tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg      960

agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac     1020

tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg     1080

ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg     1140

tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc     1200

aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc     1260

tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtc cttctagtgt     1320

agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc     1380

taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact     1440

caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac     1500

agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag     1560

aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg     1620

gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg     1680

tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga     1740

gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt     1800

ttgctcacat gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct     1860

ttgagtgagc tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg     1920

aggaagcgga agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt     1980

aatgcagctg gcacgacagg tttcccgact ggaaagcggg cagtgagcgc aacgcaatta     2040

atgtgagtta gctcactcat taggcacccc aggctttaca ctttatgctt ccggctcgta     2100

tgttgtgtgg aattgtgagc ggataacaat ttcacacagg aaacagctat gaccatgatt     2160

acgccaagcg cgcaattaac cctcactaaa gggaacaaaa gctggagctg caagcttaat     2220

gtagtcttat gcaatactct tgtagtcttg caacatggta acgatgagtt agcaacatgc     2280

cttacaagga gagaaaaagc accgtgcatg ccgattggtg gaagtaaggt ggtacgatcg     2340

tgccttatta ggaaggcaac agacgggtct gacatggatt ggacgaacca ctgaattgcc     2400

gcattgcaga gatattgtat ttaagtgcct agctcgatac aataaacggg tctctctggt     2460

tagaccagat ctgagcctgg gagctctctg gctaactagg gaacccactg cttaagcctc     2520

aataaagctt gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt gactctggta     2580

actagagatc cctcagaccc ttttagtcag tgtggaaaat ctctagcagt ggcgcccgaa     2640

cagggacctg aaagcgaaag ggaaaccaga gctctctcga cgcaggactc ggcttgctga     2700

agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa ttttgactag     2760

cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg ggagaattag     2820

atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata aattaaaaca     2880

tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc tgttagaaac     2940

atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga caggatcaga     3000

agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc aaaggataga     3060

gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca aaagtaagac     3120

caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg agggacaatt     3180

ggagaagtga attatataaa tataaagtag taaaaattga accattagga gtagcaccca     3240

ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata ggagctttgt     3300

tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcctcaatg acgctgacgg     3360

tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg ctgagggcta     3420

ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag ctccaggcaa     3480

gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt tggggttgct     3540

ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt aataaatctc     3600

tggaacagat tggaatcaca cgacctggat ggagtgggac agagaaatta acaattacac     3660

aagcttaata cactccttaa ttgaagaatc gcaaaaccag caagaaaaga atgaacaaga     3720

attattggaa ttagataaat gggcaagttt gtggaattgg tttaacataa caaattggct     3780

gtggtatata aaattattca taatgatagt aggaggcttg gtaggtttaa gaatagtttt     3840

tgctgtactt tctatagtga atagagttag gcagggatat tcaccattat cgtttcagac     3900

ccacctccca accccgaggg gacccgacag gcccgaagga atagaagaag aaggtggaga     3960

gagagacaga gacagatcca ttcgattagt gaacggatct cgacggttaa cttttaaaag     4020

aaaagggggg attggggggt acagtgcagg ggaaagaata gtagacataa tagcaacaga     4080

catacaaact aaagaattac aaaaacaaat tacaaaaatt caaaatttta tcgagctttg     4140

caaagatgga taaagtttta aacagagagg aatctttgca gctaatggac cttctaggtc     4200

ttgaaaggag tgcctcgtga ggctccggtg cccgtcagtg ggcagagcgc acatcgccca     4260

cagtccccga gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc     4320

gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg     4380

gagaaccgta tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg     4440

ccagaacaca ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg     4500

gcccttgcgt gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc     4560

ttcgggttgg aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc     4620

gtgcttgagt tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc     4680

ttcgcgcctg tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg     4740

ctgcgacgct ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg     4800

gtatttcggt ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt     4860

cggcgaggcg gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg     4920

gccggcctgc tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa     4980

ggctggcccg gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg     5040

cagggagctc aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac     5100

aaaggaaaag ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg     5160

cgccgtccag gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg     5220

gggaggggtt ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc     5280

cagcttggca cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt     5340

tcattctcaa gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag     5400

gaattcggta ccgcggccgc ccggggatcc atggccttac cagtgaccgc cttgctcctg     5460

ccgctggcct tgctgctcca cgccgccagg ccggatgttg ttatgacaca gaccccgctg     5520

agtctgcccg tctccctggg cgaccaggcc tccatttctt gccgtagttc acagtccctg     5580

gtgcactcta acggaaatac ctatctgcgc tggtacctgc agaaaccggg ccagagcccc     5640

aaagtcctga tctataaggt gtccaaccgg gtgtctggtg ttccggatcg cttttcaggg     5700

agcggcagcg gcaccgactt cacactgaag atcaatcgtg ttgaagcaga ggatctgggc     5760

gtctactttt gctctcagag tacacatgtg ccatggactt tcggcggtgg gaccaaactg     5820

gaaattaaga gctccgcaga tgacgctaaa aaggacgccg cgaaaaagga tgacgccaaa     5880

aaggatgacg cgaaaaagga tggaggcgtc aaactggacg agaccggtgg gggactggtg     5940

cagccgggcg gtgcaatgaa gctgagttgt gtgacttcag gttttacctt cgggcactat     6000

tggatgaact gggttcgtca gagtccagaa aaaggtctgg agtgggtcgc tcagtttcgg     6060

aacaagcctt acaactacga aacatactac tcagatagcg ttaaagggcg cttcactatt     6120

agccgtgatg actccaagtc tagtgtgtac ctgcagatga acaatctgcg ggttgaggac     6180

acaggcatct attactgcac aggggcgtcc tatggtatgg agtatctggg gcagggaaca     6240

agcgtcaccg tctcaaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc     6300

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg     6360

cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact     6420

tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa     6480

ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat     6540

ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc     6600

agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc     6660

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     6720

atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     6780

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     6840

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     6900

cacatgcagg ccctgccccc tcgctaagtc gacaatcaac ctctggatta caaaatttgt     6960

gaaagattga ctggtattct taactatgtt gctcctttta cgctatgtgg atacgctgct     7020

ttaatgcctt tgtatcatgc tattgcttcc cgtatggctt tcattttctc ctccttgtat     7080

aaatcctggt tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca acgtggcgtg     7140

gtgtgcactg tgtttgctga cgcaaccccc actggttggg gcattgccac cacctgtcag     7200

ctcctttccg ggactttcgc tttccccctc cctattgcca cggcggaact catcgccgcc     7260

tgccttgccc gctgctggac aggggctcgg ctgttgggca ctgacaattc cgtggtgttg     7320

tcggggaagc tgacgtcctt tccatggctg ctcgcctgtg ttgccacctg gattctgcgc     7380

gggacgtcct tctgctacgt cccttcggcc ctcaatccag cggaccttcc ttcccgcggc     7440

ctgctgccgg ctctgcggcc tcttccgcgt cttcgccttc gccctcagac gagtcggatc     7500

tccctttggg ccgcctcccc gcctggaatt cgagctcggt acctttaaga ccaatgactt     7560

acaaggcagc tgtagatctt agccactttt taaaagaaaa ggggggactg gaagggctaa     7620

ttcactccca acgaagacaa gatctgcttt ttgcttgtac tgggtctctc tggttagacc     7680

agatctgagc ctgggagctc tctggctaac tagggaaccc actgcttaag cctcaataaa     7740

gcttgccttg agtgcttcaa gtagtgtgtg cccgtctgtt gtgtgactct ggtaactaga     7800

gatccctcag acccttttag tcagtgtgga aaatctctag cagtagtagt tcatgtcatc     7860

ttattattca gtatttataa cttgcaaaga aatgaatatc agagagtgag aggaacttgt     7920

ttattgcagc ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag     7980

catttttttc actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg     8040

tctggctcta gctatcccgc ccctaactcc gcccagttcc gcccattctc cgccccatgg     8100

ctgactaatt ttttttattt atgcagaggc cgaggccgcc tcggcctctg agctattcca     8160

gaagtagtga ggaggctttt ttggaggcct aggcttttgc gtcgagacgt acccaattcg     8220

ccctatagtg agtcgtatta cgcgcgctca ctggccgtcg ttttacaacg tcgtgactgg     8280

gaaaaccctg gcgttaccca acttaatcgc cttgcagcac atcccccttt cgccagctgg     8340

cgtaatagcg aagaggcccg caccgatcgc ccttcccaac agttgcgcag cctgaatggc     8400

gaatggcgcg acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt ggttacgcgc     8460

agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt cttcccttcc     8520

tttctcgcca cgttcgccgg ctttccccgt caagctctaa atcgggggct ccctttaggg     8580

ttccgattta gtgctttacg gcacctcgac cccaaaaaac ttgattaggg tgatggttca     8640

cgtagtgggc catcgccctg atagacggtt tttcgccctt tgacgttgga gtccacgttc     8700

tttaatagtg gactcttgtt ccaaactgga acaacactca accctatctc ggtctattct     8760

tttgatttat aagggatttt gccgatttcg gcctattggt taaaaaatga gctgatttaa     8820

caaaaattta acgcgaattt taacaaaata ttaacgttta caatttcc                  8868


<210>  4
<211>  8859
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in lab - LV-EF1a-FITC(E2)-BBZ chimeric antigen receptor 
       polynucleotide

<400>  4
caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac       60

attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa      120

aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat      180

tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc      240

agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga      300

gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg      360

cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc      420

agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag      480

taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc      540

tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg      600

taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg      660

acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac      720

ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac      780

cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg      840

agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg      900

tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg      960

agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac     1020

tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg     1080

ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg     1140

tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc     1200

aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc     1260

tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtc cttctagtgt     1320

agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc     1380

taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact     1440

caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac     1500

agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag     1560

aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg     1620

gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg     1680

tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga     1740

gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt     1800

ttgctcacat gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct     1860

ttgagtgagc tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg     1920

aggaagcgga agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt     1980

aatgcagctg gcacgacagg tttcccgact ggaaagcggg cagtgagcgc aacgcaatta     2040

atgtgagtta gctcactcat taggcacccc aggctttaca ctttatgctt ccggctcgta     2100

tgttgtgtgg aattgtgagc ggataacaat ttcacacagg aaacagctat gaccatgatt     2160

acgccaagcg cgcaattaac cctcactaaa gggaacaaaa gctggagctg caagcttaat     2220

gtagtcttat gcaatactct tgtagtcttg caacatggta acgatgagtt agcaacatgc     2280

cttacaagga gagaaaaagc accgtgcatg ccgattggtg gaagtaaggt ggtacgatcg     2340

tgccttatta ggaaggcaac agacgggtct gacatggatt ggacgaacca ctgaattgcc     2400

gcattgcaga gatattgtat ttaagtgcct agctcgatac aataaacggg tctctctggt     2460

tagaccagat ctgagcctgg gagctctctg gctaactagg gaacccactg cttaagcctc     2520

aataaagctt gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt gactctggta     2580

actagagatc cctcagaccc ttttagtcag tgtggaaaat ctctagcagt ggcgcccgaa     2640

cagggacctg aaagcgaaag ggaaaccaga gctctctcga cgcaggactc ggcttgctga     2700

agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa ttttgactag     2760

cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg ggagaattag     2820

atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata aattaaaaca     2880

tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc tgttagaaac     2940

atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga caggatcaga     3000

agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc aaaggataga     3060

gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca aaagtaagac     3120

caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg agggacaatt     3180

ggagaagtga attatataaa tataaagtag taaaaattga accattagga gtagcaccca     3240

ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata ggagctttgt     3300

tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcctcaatg acgctgacgg     3360

tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg ctgagggcta     3420

ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag ctccaggcaa     3480

gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt tggggttgct     3540

ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt aataaatctc     3600

tggaacagat tggaatcaca cgacctggat ggagtgggac agagaaatta acaattacac     3660

aagcttaata cactccttaa ttgaagaatc gcaaaaccag caagaaaaga atgaacaaga     3720

attattggaa ttagataaat gggcaagttt gtggaattgg tttaacataa caaattggct     3780

gtggtatata aaattattca taatgatagt aggaggcttg gtaggtttaa gaatagtttt     3840

tgctgtactt tctatagtga atagagttag gcagggatat tcaccattat cgtttcagac     3900

ccacctccca accccgaggg gacccgacag gcccgaagga atagaagaag aaggtggaga     3960

gagagacaga gacagatcca ttcgattagt gaacggatct cgacggttaa cttttaaaag     4020

aaaagggggg attggggggt acagtgcagg ggaaagaata gtagacataa tagcaacaga     4080

catacaaact aaagaattac aaaaacaaat tacaaaaatt caaaatttta tcgagctttg     4140

caaagatgga taaagtttta aacagagagg aatctttgca gctaatggac cttctaggtc     4200

ttgaaaggag tgcctcgtga ggctccggtg cccgtcagtg ggcagagcgc acatcgccca     4260

cagtccccga gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc     4320

gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg     4380

gagaaccgta tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg     4440

ccagaacaca ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg     4500

gcccttgcgt gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc     4560

ttcgggttgg aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc     4620

gtgcttgagt tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc     4680

ttcgcgcctg tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg     4740

ctgcgacgct ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg     4800

gtatttcggt ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt     4860

cggcgaggcg gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg     4920

gccggcctgc tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa     4980

ggctggcccg gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg     5040

cagggagctc aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac     5100

aaaggaaaag ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg     5160

cgccgtccag gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg     5220

gggaggggtt ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc     5280

cagcttggca cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt     5340

tcattctcaa gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag     5400

gaattcggta ccgcggccgc ccggggatcc atggccttac cagtgaccgc cttgctcctg     5460

ccgctggcct tgctgctcca cgccgccagg ccgcaggttc agctggttga gagcggaggc     5520

aatctggttc agcccggtgg tagtctgcgt ctgtcttgtg cggcgtcagg gttcactttc     5580

ggtagttttt caatgagctg ggtccgtcag gcaccaggcg gtgggctgga atgggtggca     5640

ggtctgtctg cacgtagctc cctgacccac tatgcagata gtgttaaagg gcggttcaca     5700

atttcacgcg acaacgctaa gaatagcgtc tacctgcaaa tgaactccct gcgggtcgag     5760

gataccgcag tgtattactg cgctcgccgt tcttatgact ctagtggata ctggggccat     5820

ttttatagct acatggatgt gtggggacag ggcactctgg tgaccgtttc cggaggcggt     5880

gggtctggag gcggtgggag tggaggcggt gggtcaagcg ttctgaccca gccgtcctct     5940

gtcagcgccg cgccaggcca gaaagtgaca atttcctgtt ctggaagtac ttcaaacatc     6000

ggcaacaatt atgtttcctg gtatcagcag cacccgggca aagcgcccaa gctgatgatt     6060

tatgatgtgt ctaaacgtcc aagtggtgtt cctgaccggt tcagcggttc caagtctggg     6120

aatagtgcct cactggacat ctcaggcctg caaagcgaag atgaggcgga ctattactgc     6180

gcagcttggg atgacagcct gtccgaattt ctgttcggca ccgggacaaa gctgaccgtg     6240

ctgggcacca cgacgccagc gccgcgacca ccaacaccgg cgcccaccat cgcgtcgcag     6300

cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg ggggcgcagt gcacacgagg     6360

gggctggact tcgcctgtga tatctacatc tgggcgccct tggccgggac ttgtggggtc     6420

cttctcctgt cactggttat caccctttac tgcaaacggg gcagaaagaa actcctgtat     6480

atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc     6540

tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc     6600

gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga     6660

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga     6720

aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg     6780

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     6840

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag     6900

gccctgcccc ctcgctaagt cgacaatcaa cctctggatt acaaaatttg tgaaagattg     6960

actggtattc ttaactatgt tgctcctttt acgctatgtg gatacgctgc tttaatgcct     7020

ttgtatcatg ctattgcttc ccgtatggct ttcattttct cctccttgta taaatcctgg     7080

ttgctgtctc tttatgagga gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact     7140

gtgtttgctg acgcaacccc cactggttgg ggcattgcca ccacctgtca gctcctttcc     7200

gggactttcg ctttccccct ccctattgcc acggcggaac tcatcgccgc ctgccttgcc     7260

cgctgctgga caggggctcg gctgttgggc actgacaatt ccgtggtgtt gtcggggaag     7320

ctgacgtcct ttccatggct gctcgcctgt gttgccacct ggattctgcg cgggacgtcc     7380

ttctgctacg tcccttcggc cctcaatcca gcggaccttc cttcccgcgg cctgctgccg     7440

gctctgcggc ctcttccgcg tcttcgcctt cgccctcaga cgagtcggat ctccctttgg     7500

gccgcctccc cgcctggaat tcgagctcgg tacctttaag accaatgact tacaaggcag     7560

ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta attcactccc     7620

aacgaagaca agatctgctt tttgcttgta ctgggtctct ctggttagac cagatctgag     7680

cctgggagct ctctggctaa ctagggaacc cactgcttaa gcctcaataa agcttgcctt     7740

gagtgcttca agtagtgtgt gcccgtctgt tgtgtgactc tggtaactag agatccctca     7800

gaccctttta gtcagtgtgg aaaatctcta gcagtagtag ttcatgtcat cttattattc     7860

agtatttata acttgcaaag aaatgaatat cagagagtga gaggaacttg tttattgcag     7920

cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt     7980

cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctggctct     8040

agctatcccg cccctaactc cgcccagttc cgcccattct ccgccccatg gctgactaat     8100

tttttttatt tatgcagagg ccgaggccgc ctcggcctct gagctattcc agaagtagtg     8160

aggaggcttt tttggaggcc taggcttttg cgtcgagacg tacccaattc gccctatagt     8220

gagtcgtatt acgcgcgctc actggccgtc gttttacaac gtcgtgactg ggaaaaccct     8280

ggcgttaccc aacttaatcg ccttgcagca catccccctt tcgccagctg gcgtaatagc     8340

gaagaggccc gcaccgatcg cccttcccaa cagttgcgca gcctgaatgg cgaatggcgc     8400

gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc     8460

gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc     8520

acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt     8580

agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg     8640

ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt     8700

ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta     8760

taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt     8820

aacgcgaatt ttaacaaaat attaacgttt acaatttcc                            8859


<210>  5
<211>  5574
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - pBAD-CD19wt CAR-EC switch target interacting domain
       polynucleotide

<400>  5
aagaaaccaa ttgtccatat tgcatcagac attgccgtca ctgcgtcttt tactggctct       60

tctcgctaac caaaccggta accctgatta tttgcacgga gtcacacttt gctatgccat      120

agcattttta tccataagat tagcggatcc tacctgacgc tttttatcgc aactctctac      180

tgtttctcca tacccgtttt tttgggctag aaataatttt gtttaacttt aagaaggaga      240

atacatcaac tagtacgcaa gttcacgtaa aaagggtatc tagaggttga ggtgatttta      300

tgaaaaagaa tatcgcattt cttcttgcta gcatgttcgt tttttctatt gctacaaacg      360

catacgctga catccagatg acacagacta catcctccct gtctgcctct ctgggagaca      420

gagtcaccat cagttgcagg gcaagtcagg acattagtaa atatttaaat tggtatcagc      480

agaaaccaga tggaactgtt aaactcctga tctaccatac atcaagatta cactcaggag      540

tcccatcaag gttcagtggc agtgggtctg gaacagatta ttctctcacc attagcaacc      600

tggagcaaga agatattgcc acttactttt gccaacaggg taatacgctt ccgtacacgt      660

tcggaggggg gaccaagctt gagatcaaac gaactgtggc tgcaccatct gtcttcatct      720

tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgtcgtgtgc ctgctgaata      780

acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc caatcgggta      840

actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc ctcagcagca      900

ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc gaagtcaccc      960

atcagggcct gtcctcgccc gtcacaaaga gcttcaacag gggagagtgt taagctgggg     1020

atcctctaga ggttgaggtg attttatgaa aaagaatatc gcatttcttc ttgcatctat     1080

gttcgttttt tctattgcta caaacgcgta cgctgaggtg aaactgcagg agtcaggacc     1140

tggcctggtg gcgccctcac agagcctgtc cgtcacatgc actgtctcag gggtctcatt     1200

acccgactat ggtgtaagct ggattcgcca gcctccacga aagggtctgg agtggctggg     1260

agtaatatgg ggtagtgaaa ccacatacta taattcagct ctcaaatcca gactgaccat     1320

catcaaggac aactccaaga gccaagtttt cttaaaaatg aacagtctgc aaactgatga     1380

cacagccatt tactactgtg ccaaacatta ttactacggt ggtagctatg ctatggacta     1440

ctggggccaa ggaacctcag tcaccgtctc ctcagcctcc accaagggcc catcggtctt     1500

ccccctggca ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt     1560

caaggactac ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg     1620

cgtgcacacc ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt     1680

gactgtgccc tctagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc     1740

cagcaacacc aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacata     1800

ataagtcgac cgatgccctt gagagccttc aacccagtca gctccttccg gtgggcgcgg     1860

ggcatgacta tcgtcgccgc acttatgact gtcttcttta tcatgcaact cgtaggacag     1920

gtgccaaacg gtctccagct tggctgtttt ggcggatgag agaagatttt cagcctgata     1980

cagattaaat cagaacgcag aagcggtctg ataaaacaga atttgcctgg cggcagtagc     2040

gcggtggtcc cacctgaccc catgccgaac tcagaagtga aacgccgtag cgccgatggt     2100

agtgtggggt ctccccatgc gagagtaggg aactgccagg catcaaataa aacgaaaggc     2160

tcagtcgaaa gactgggcct ttcgttttat ctgttgtttg tcggtgaacg ctctcctgag     2220

taggacaaat ccgccgggag cggatttgaa cgttgcgaag caacggcccg gagggtggcg     2280

ggcaggacgc ccgccataaa ctgccaggca tcaaattaag cagaaggcca tcctgacgga     2340

tggccttttt gcgtttctac aaactctttt tgtttatttt tctaaataca ttcaaatatg     2400

tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa aaggaagagt     2460

atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt ttgccttcct     2520

gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca     2580

cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag ttttcgcccc     2640

gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc ggtattatcc     2700

cgtgttgacg ccgggcaaga gcaactcggt cgccgcatac actattctca gaatgacttg     2760

gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt aagagaatta     2820

tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct gacaacgatc     2880

ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt aactcgcctt     2940

gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga caccacgatg     3000

cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact tactctagct     3060

tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc acttctgcgc     3120

tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga gcgtgggtct     3180

cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt agttatctac     3240

acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga gataggtgcc     3300

tcactgatta agcattggta actgtcagac caagtttact catatatact ttagattgat     3360

ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga taatctcatg     3420

accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt agaaaagatc     3480

aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa     3540

ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag     3600

gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta gccgtagtta     3660

ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta     3720

ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag     3780

ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg     3840

gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga aagcgccacg     3900

cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag     3960

cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc     4020

cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa     4080

aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg     4140

ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt tgagtgagct     4200

gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga ggaagcggaa     4260

gagcgcctga tgcggtattt tctccttacg catctgtgcg gtatttcaca ccgcatatgg     4320

tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagtatac actccgctat     4380

cgctacgtga ctgggtcatg gctgcgcccc gacacccgcc aacacccgct gacgcgccct     4440

gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct     4500

gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gaggcagcag atcaattcgc     4560

gcgcgaaggc gaagcggcat gcataatgtg cctgtcaaat ggacgaagca gggattctgc     4620

aaaccctatg ctactccgtc aagccgtcaa ttgtctgatt cgttaccaat tatgacaact     4680

tgacggctac atcattcact ttttcttcac aaccggcacg gaactcgctc gggctggccc     4740

cggtgcattt tttaaatacc cgcgagaaat agagttgatc gtcaaaacca acattgcgac     4800

cgacggtggc gataggcatc cgggtggtgc tcaaaagcag cttcgcctgg ctgatacgtt     4860

ggtcctcgcg ccagcttaag acgctaatcc ctaactgctg gcggaaaaga tgtgacagac     4920

gcgacggcga caagcaaaca tgctgtgcga cgctggcgat atcaaaattg ctgtctgcca     4980

ggtgatcgct gatgtactga caagcctcgc gtacccgatt atccatcggt ggatggagcg     5040

actcgttaat cgcttccatg cgccgcagta acaattgctc aagcagattt atcgccagca     5100

gctccgaata gcgcccttcc ccttgcccgg cgttaatgat ttgcccaaac aggtcgctga     5160

aatgcggctg gtgcgcttca tccgggcgaa agaaccccgt attggcaaat attgacggcc     5220

agttaagcca ttcatgccag taggcgcgcg gacgaaagta aacccactgg tgataccatt     5280

cgcgagcctc cggatgacga ccgtagtgat gaatctctcc tggcgggaac agcaaaatat     5340

cacccggtcg gcaaacaaat tctcgtccct gatttttcac caccccctga ccgcgaatgg     5400

tgagattgag aatataacct ttcattccca gcggtcggtc gataaaaaaa tcgagataac     5460

cgttggcctc aatcggcgtt aaacccgcca ccagatgggc attaaacgag tatcccggca     5520

gcaggggatc attttgcgct tcagccatac ttttcatact cccgccattc agag           5574


<210>  6
<211>  5574
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - pBAD-CD19 LS202X mt CAR-EC switch target 
       interacting domain polynucleotide

<400>  6
aagaaaccaa ttgtccatat tgcatcagac attgccgtca ctgcgtcttt tactggctct       60

tctcgctaac caaaccggta accctgatta tttgcacgga gtcacacttt gctatgccat      120

agcattttta tccataagat tagcggatcc tacctgacgc tttttatcgc aactctctac      180

tgtttctcca tacccgtttt tttgggctag aaataatttt gtttaacttt aagaaggaga      240

atacatcaac tagtacgcaa gttcacgtaa aaagggtatc tagaggttga ggtgatttta      300

tgaaaaagaa tatcgcattt cttcttgcta gcatgttcgt tttttctatt gctacaaacg      360

catacgctga catccagatg acacagacta catcctccct gtctgcctct ctgggagaca      420

gagtcaccat cagttgcagg gcaagtcagg acattagtaa atatttaaat tggtatcagc      480

agaaaccaga tggaactgtt aaactcctga tctaccatac atcaagatta cactcaggag      540

tcccatcaag gttcagtggc agtgggtctg gaacagatta ttctctcacc attagcaacc      600

tggagcaaga agatattgcc acttactttt gccaacaggg taatacgctt ccgtacacgt      660

tcggaggggg gaccaagctt gagatcaaac gaactgtggc tgcaccatct gtcttcatct      720

tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgtcgtgtgc ctgctgaata      780

acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc caatcgggta      840

actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc ctcagcagca      900

ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc gaagtcaccc      960

atcagggcct gtagtcgccc gtcacaaaga gcttcaacag gggagagtgt taagctgggg     1020

atcctctaga ggttgaggtg attttatgaa aaagaatatc gcatttcttc ttgcatctat     1080

gttcgttttt tctattgcta caaacgcgta cgctgaggtg aaactgcagg agtcaggacc     1140

tggcctggtg gcgccctcac agagcctgtc cgtcacatgc actgtctcag gggtctcatt     1200

acccgactat ggtgtaagct ggattcgcca gcctccacga aagggtctgg agtggctggg     1260

agtaatatgg ggtagtgaaa ccacatacta taattcagct ctcaaatcca gactgaccat     1320

catcaaggac aactccaaga gccaagtttt cttaaaaatg aacagtctgc aaactgatga     1380

cacagccatt tactactgtg ccaaacatta ttactacggt ggtagctatg ctatggacta     1440

ctggggccaa ggaacctcag tcaccgtctc ctcagcctcc accaagggcc catcggtctt     1500

ccccctggca ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt     1560

caaggactac ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg     1620

cgtgcacacc ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt     1680

gactgtgccc tctagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc     1740

cagcaacacc aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacata     1800

ataagtcgac cgatgccctt gagagccttc aacccagtca gctccttccg gtgggcgcgg     1860

ggcatgacta tcgtcgccgc acttatgact gtcttcttta tcatgcaact cgtaggacag     1920

gtgccaaacg gtctccagct tggctgtttt ggcggatgag agaagatttt cagcctgata     1980

cagattaaat cagaacgcag aagcggtctg ataaaacaga atttgcctgg cggcagtagc     2040

gcggtggtcc cacctgaccc catgccgaac tcagaagtga aacgccgtag cgccgatggt     2100

agtgtggggt ctccccatgc gagagtaggg aactgccagg catcaaataa aacgaaaggc     2160

tcagtcgaaa gactgggcct ttcgttttat ctgttgtttg tcggtgaacg ctctcctgag     2220

taggacaaat ccgccgggag cggatttgaa cgttgcgaag caacggcccg gagggtggcg     2280

ggcaggacgc ccgccataaa ctgccaggca tcaaattaag cagaaggcca tcctgacgga     2340

tggccttttt gcgtttctac aaactctttt tgtttatttt tctaaataca ttcaaatatg     2400

tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa aaggaagagt     2460

atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt ttgccttcct     2520

gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca     2580

cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag ttttcgcccc     2640

gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc ggtattatcc     2700

cgtgttgacg ccgggcaaga gcaactcggt cgccgcatac actattctca gaatgacttg     2760

gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt aagagaatta     2820

tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct gacaacgatc     2880

ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt aactcgcctt     2940

gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga caccacgatg     3000

cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact tactctagct     3060

tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc acttctgcgc     3120

tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga gcgtgggtct     3180

cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt agttatctac     3240

acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga gataggtgcc     3300

tcactgatta agcattggta actgtcagac caagtttact catatatact ttagattgat     3360

ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga taatctcatg     3420

accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt agaaaagatc     3480

aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa     3540

ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag     3600

gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta gccgtagtta     3660

ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta     3720

ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag     3780

ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg     3840

gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga aagcgccacg     3900

cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag     3960

cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc     4020

cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa     4080

aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg     4140

ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt tgagtgagct     4200

gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga ggaagcggaa     4260

gagcgcctga tgcggtattt tctccttacg catctgtgcg gtatttcaca ccgcatatgg     4320

tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagtatac actccgctat     4380

cgctacgtga ctgggtcatg gctgcgcccc gacacccgcc aacacccgct gacgcgccct     4440

gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct     4500

gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gaggcagcag atcaattcgc     4560

gcgcgaaggc gaagcggcat gcataatgtg cctgtcaaat ggacgaagca gggattctgc     4620

aaaccctatg ctactccgtc aagccgtcaa ttgtctgatt cgttaccaat tatgacaact     4680

tgacggctac atcattcact ttttcttcac aaccggcacg gaactcgctc gggctggccc     4740

cggtgcattt tttaaatacc cgcgagaaat agagttgatc gtcaaaacca acattgcgac     4800

cgacggtggc gataggcatc cgggtggtgc tcaaaagcag cttcgcctgg ctgatacgtt     4860

ggtcctcgcg ccagcttaag acgctaatcc ctaactgctg gcggaaaaga tgtgacagac     4920

gcgacggcga caagcaaaca tgctgtgcga cgctggcgat atcaaaattg ctgtctgcca     4980

ggtgatcgct gatgtactga caagcctcgc gtacccgatt atccatcggt ggatggagcg     5040

actcgttaat cgcttccatg cgccgcagta acaattgctc aagcagattt atcgccagca     5100

gctccgaata gcgcccttcc ccttgcccgg cgttaatgat ttgcccaaac aggtcgctga     5160

aatgcggctg gtgcgcttca tccgggcgaa agaaccccgt attggcaaat attgacggcc     5220

agttaagcca ttcatgccag taggcgcgcg gacgaaagta aacccactgg tgataccatt     5280

cgcgagcctc cggatgacga ccgtagtgat gaatctctcc tggcgggaac agcaaaatat     5340

cacccggtcg gcaaacaaat tctcgtccct gatttttcac caccccctga ccgcgaatgg     5400

tgagattgag aatataacct ttcattccca gcggtcggtc gataaaaaaa tcgagataac     5460

cgttggcctc aatcggcgtt aaacccgcca ccagatgggc attaaacgag tatcccggca     5520

gcaggggatc attttgcgct tcagccatac ttttcatact cccgccattc agag           5574


<210>  7
<211>  5574
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - pBAD-CD19 HK136X mt CAR-EC switch target 
       interacting domain polynucleotide

<400>  7
aagaaaccaa ttgtccatat tgcatcagac attgccgtca ctgcgtcttt tactggctct       60

tctcgctaac caaaccggta accctgatta tttgcacgga gtcacacttt gctatgccat      120

agcattttta tccataagat tagcggatcc tacctgacgc tttttatcgc aactctctac      180

tgtttctcca tacccgtttt tttgggctag aaataatttt gtttaacttt aagaaggaga      240

atacatcaac tagtacgcaa gttcacgtaa aaagggtatc tagaggttga ggtgatttta      300

tgaaaaagaa tatcgcattt cttcttgcta gcatgttcgt tttttctatt gctacaaacg      360

catacgctga catccagatg acacagacta catcctccct gtctgcctct ctgggagaca      420

gagtcaccat cagttgcagg gcaagtcagg acattagtaa atatttaaat tggtatcagc      480

agaaaccaga tggaactgtt aaactcctga tctaccatac atcaagatta cactcaggag      540

tcccatcaag gttcagtggc agtgggtctg gaacagatta ttctctcacc attagcaacc      600

tggagcaaga agatattgcc acttactttt gccaacaggg taatacgctt ccgtacacgt      660

tcggaggggg gaccaagctt gagatcaaac gaactgtggc tgcaccatct gtcttcatct      720

tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgtcgtgtgc ctgctgaata      780

acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc caatcgggta      840

actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc ctcagcagca      900

ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc gaagtcaccc      960

atcagggcct gtcctcgccc gtcacaaaga gcttcaacag gggagagtgt taagctgggg     1020

atcctctaga ggttgaggtg attttatgaa aaagaatatc gcatttcttc ttgcatctat     1080

gttcgttttt tctattgcta caaacgcgta cgctgaggtg aaactgcagg agtcaggacc     1140

tggcctggtg gcgccctcac agagcctgtc cgtcacatgc actgtctcag gggtctcatt     1200

acccgactat ggtgtaagct ggattcgcca gcctccacga aagggtctgg agtggctggg     1260

agtaatatgg ggtagtgaaa ccacatacta taattcagct ctcaaatcca gactgaccat     1320

catcaaggac aactccaaga gccaagtttt cttaaaaatg aacagtctgc aaactgatga     1380

cacagccatt tactactgtg ccaaacatta ttactacggt ggtagctatg ctatggacta     1440

ctggggccaa ggaacctcag tcaccgtctc ctcagcctcc accaagggcc catcggtctt     1500

ccccctggca ccctcctcct agagcacctc tgggggcaca gcggccctgg gctgcctggt     1560

caaggactac ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg     1620

cgtgcacacc ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt     1680

gactgtgccc tctagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc     1740

cagcaacacc aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacata     1800

ataagtcgac cgatgccctt gagagccttc aacccagtca gctccttccg gtgggcgcgg     1860

ggcatgacta tcgtcgccgc acttatgact gtcttcttta tcatgcaact cgtaggacag     1920

gtgccaaacg gtctccagct tggctgtttt ggcggatgag agaagatttt cagcctgata     1980

cagattaaat cagaacgcag aagcggtctg ataaaacaga atttgcctgg cggcagtagc     2040

gcggtggtcc cacctgaccc catgccgaac tcagaagtga aacgccgtag cgccgatggt     2100

agtgtggggt ctccccatgc gagagtaggg aactgccagg catcaaataa aacgaaaggc     2160

tcagtcgaaa gactgggcct ttcgttttat ctgttgtttg tcggtgaacg ctctcctgag     2220

taggacaaat ccgccgggag cggatttgaa cgttgcgaag caacggcccg gagggtggcg     2280

ggcaggacgc ccgccataaa ctgccaggca tcaaattaag cagaaggcca tcctgacgga     2340

tggccttttt gcgtttctac aaactctttt tgtttatttt tctaaataca ttcaaatatg     2400

tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa aaggaagagt     2460

atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt ttgccttcct     2520

gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca     2580

cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag ttttcgcccc     2640

gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc ggtattatcc     2700

cgtgttgacg ccgggcaaga gcaactcggt cgccgcatac actattctca gaatgacttg     2760

gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt aagagaatta     2820

tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct gacaacgatc     2880

ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt aactcgcctt     2940

gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga caccacgatg     3000

cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact tactctagct     3060

tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc acttctgcgc     3120

tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga gcgtgggtct     3180

cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt agttatctac     3240

acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga gataggtgcc     3300

tcactgatta agcattggta actgtcagac caagtttact catatatact ttagattgat     3360

ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga taatctcatg     3420

accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt agaaaagatc     3480

aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa     3540

ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag     3600

gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta gccgtagtta     3660

ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta     3720

ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag     3780

ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg     3840

gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga aagcgccacg     3900

cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag     3960

cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc     4020

cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa     4080

aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg     4140

ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt tgagtgagct     4200

gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga ggaagcggaa     4260

gagcgcctga tgcggtattt tctccttacg catctgtgcg gtatttcaca ccgcatatgg     4320

tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagtatac actccgctat     4380

cgctacgtga ctgggtcatg gctgcgcccc gacacccgcc aacacccgct gacgcgccct     4440

gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct     4500

gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gaggcagcag atcaattcgc     4560

gcgcgaaggc gaagcggcat gcataatgtg cctgtcaaat ggacgaagca gggattctgc     4620

aaaccctatg ctactccgtc aagccgtcaa ttgtctgatt cgttaccaat tatgacaact     4680

tgacggctac atcattcact ttttcttcac aaccggcacg gaactcgctc gggctggccc     4740

cggtgcattt tttaaatacc cgcgagaaat agagttgatc gtcaaaacca acattgcgac     4800

cgacggtggc gataggcatc cgggtggtgc tcaaaagcag cttcgcctgg ctgatacgtt     4860

ggtcctcgcg ccagcttaag acgctaatcc ctaactgctg gcggaaaaga tgtgacagac     4920

gcgacggcga caagcaaaca tgctgtgcga cgctggcgat atcaaaattg ctgtctgcca     4980

ggtgatcgct gatgtactga caagcctcgc gtacccgatt atccatcggt ggatggagcg     5040

actcgttaat cgcttccatg cgccgcagta acaattgctc aagcagattt atcgccagca     5100

gctccgaata gcgcccttcc ccttgcccgg cgttaatgat ttgcccaaac aggtcgctga     5160

aatgcggctg gtgcgcttca tccgggcgaa agaaccccgt attggcaaat attgacggcc     5220

agttaagcca ttcatgccag taggcgcgcg gacgaaagta aacccactgg tgataccatt     5280

cgcgagcctc cggatgacga ccgtagtgat gaatctctcc tggcgggaac agcaaaatat     5340

cacccggtcg gcaaacaaat tctcgtccct gatttttcac caccccctga ccgcgaatgg     5400

tgagattgag aatataacct ttcattccca gcggtcggtc gataaaaaaa tcgagataac     5460

cgttggcctc aatcggcgtt aaacccgcca ccagatgggc attaaacgag tatcccggca     5520

gcaggggatc attttgcgct tcagccatac ttttcatact cccgccattc agag           5574


<210>  8
<211>  5574
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - pBAD-CD19 LS202/HK136X mt CAR-EC switch target 
       interacting domain polynucleotide

<400>  8
aagaaaccaa ttgtccatat tgcatcagac attgccgtca ctgcgtcttt tactggctct       60

tctcgctaac caaaccggta accctgatta tttgcacgga gtcacacttt gctatgccat      120

agcattttta tccataagat tagcggatcc tacctgacgc tttttatcgc aactctctac      180

tgtttctcca tacccgtttt tttgggctag aaataatttt gtttaacttt aagaaggaga      240

atacatcaac tagtacgcaa gttcacgtaa aaagggtatc tagaggttga ggtgatttta      300

tgaaaaagaa tatcgcattt cttcttgcta gcatgttcgt tttttctatt gctacaaacg      360

catacgctga catccagatg acacagacta catcctccct gtctgcctct ctgggagaca      420

gagtcaccat cagttgcagg gcaagtcagg acattagtaa atatttaaat tggtatcagc      480

agaaaccaga tggaactgtt aaactcctga tctaccatac atcaagatta cactcaggag      540

tcccatcaag gttcagtggc agtgggtctg gaacagatta ttctctcacc attagcaacc      600

tggagcaaga agatattgcc acttactttt gccaacaggg taatacgctt ccgtacacgt      660

tcggaggggg gaccaagctt gagatcaaac gaactgtggc tgcaccatct gtcttcatct      720

tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgtcgtgtgc ctgctgaata      780

acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc caatcgggta      840

actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc ctcagcagca      900

ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc gaagtcaccc      960

atcagggcct gtagtcgccc gtcacaaaga gcttcaacag gggagagtgt taagctgggg     1020

atcctctaga ggttgaggtg attttatgaa aaagaatatc gcatttcttc ttgcatctat     1080

gttcgttttt tctattgcta caaacgcgta cgctgaggtg aaactgcagg agtcaggacc     1140

tggcctggtg gcgccctcac agagcctgtc cgtcacatgc actgtctcag gggtctcatt     1200

acccgactat ggtgtaagct ggattcgcca gcctccacga aagggtctgg agtggctggg     1260

agtaatatgg ggtagtgaaa ccacatacta taattcagct ctcaaatcca gactgaccat     1320

catcaaggac aactccaaga gccaagtttt cttaaaaatg aacagtctgc aaactgatga     1380

cacagccatt tactactgtg ccaaacatta ttactacggt ggtagctatg ctatggacta     1440

ctggggccaa ggaacctcag tcaccgtctc ctcagcctcc accaagggcc catcggtctt     1500

ccccctggca ccctcctcct agagcacctc tgggggcaca gcggccctgg gctgcctggt     1560

caaggactac ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg     1620

cgtgcacacc ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt     1680

gactgtgccc tctagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc     1740

cagcaacacc aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacata     1800

ataagtcgac cgatgccctt gagagccttc aacccagtca gctccttccg gtgggcgcgg     1860

ggcatgacta tcgtcgccgc acttatgact gtcttcttta tcatgcaact cgtaggacag     1920

gtgccaaacg gtctccagct tggctgtttt ggcggatgag agaagatttt cagcctgata     1980

cagattaaat cagaacgcag aagcggtctg ataaaacaga atttgcctgg cggcagtagc     2040

gcggtggtcc cacctgaccc catgccgaac tcagaagtga aacgccgtag cgccgatggt     2100

agtgtggggt ctccccatgc gagagtaggg aactgccagg catcaaataa aacgaaaggc     2160

tcagtcgaaa gactgggcct ttcgttttat ctgttgtttg tcggtgaacg ctctcctgag     2220

taggacaaat ccgccgggag cggatttgaa cgttgcgaag caacggcccg gagggtggcg     2280

ggcaggacgc ccgccataaa ctgccaggca tcaaattaag cagaaggcca tcctgacgga     2340

tggccttttt gcgtttctac aaactctttt tgtttatttt tctaaataca ttcaaatatg     2400

tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa aaggaagagt     2460

atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt ttgccttcct     2520

gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca     2580

cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag ttttcgcccc     2640

gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc ggtattatcc     2700

cgtgttgacg ccgggcaaga gcaactcggt cgccgcatac actattctca gaatgacttg     2760

gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt aagagaatta     2820

tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct gacaacgatc     2880

ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt aactcgcctt     2940

gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga caccacgatg     3000

cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact tactctagct     3060

tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc acttctgcgc     3120

tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga gcgtgggtct     3180

cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt agttatctac     3240

acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga gataggtgcc     3300

tcactgatta agcattggta actgtcagac caagtttact catatatact ttagattgat     3360

ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga taatctcatg     3420

accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt agaaaagatc     3480

aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa     3540

ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag     3600

gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta gccgtagtta     3660

ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta     3720

ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag     3780

ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg     3840

gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga aagcgccacg     3900

cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag     3960

cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc     4020

cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa     4080

aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg     4140

ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt tgagtgagct     4200

gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga ggaagcggaa     4260

gagcgcctga tgcggtattt tctccttacg catctgtgcg gtatttcaca ccgcatatgg     4320

tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagtatac actccgctat     4380

cgctacgtga ctgggtcatg gctgcgcccc gacacccgcc aacacccgct gacgcgccct     4440

gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct     4500

gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gaggcagcag atcaattcgc     4560

gcgcgaaggc gaagcggcat gcataatgtg cctgtcaaat ggacgaagca gggattctgc     4620

aaaccctatg ctactccgtc aagccgtcaa ttgtctgatt cgttaccaat tatgacaact     4680

tgacggctac atcattcact ttttcttcac aaccggcacg gaactcgctc gggctggccc     4740

cggtgcattt tttaaatacc cgcgagaaat agagttgatc gtcaaaacca acattgcgac     4800

cgacggtggc gataggcatc cgggtggtgc tcaaaagcag cttcgcctgg ctgatacgtt     4860

ggtcctcgcg ccagcttaag acgctaatcc ctaactgctg gcggaaaaga tgtgacagac     4920

gcgacggcga caagcaaaca tgctgtgcga cgctggcgat atcaaaattg ctgtctgcca     4980

ggtgatcgct gatgtactga caagcctcgc gtacccgatt atccatcggt ggatggagcg     5040

actcgttaat cgcttccatg cgccgcagta acaattgctc aagcagattt atcgccagca     5100

gctccgaata gcgcccttcc ccttgcccgg cgttaatgat ttgcccaaac aggtcgctga     5160

aatgcggctg gtgcgcttca tccgggcgaa agaaccccgt attggcaaat attgacggcc     5220

agttaagcca ttcatgccag taggcgcgcg gacgaaagta aacccactgg tgataccatt     5280

cgcgagcctc cggatgacga ccgtagtgat gaatctctcc tggcgggaac agcaaaatat     5340

cacccggtcg gcaaacaaat tctcgtccct gatttttcac caccccctga ccgcgaatgg     5400

tgagattgag aatataacct ttcattccca gcggtcggtc gataaaaaaa tcgagataac     5460

cgttggcctc aatcggcgtt aaacccgcca ccagatgggc attaaacgag tatcccggca     5520

gcaggggatc attttgcgct tcagccatac ttttcatact cccgccattc agag           5574


<210>  9
<211>  8832
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - LV-EF1a-CD19(FMC63)-BBZ CAR-EC switch target 
       interacting domain polynucleotide

<400>  9
caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac       60

attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa      120

aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat      180

tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc      240

agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga      300

gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg      360

cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc      420

agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag      480

taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc      540

tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg      600

taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg      660

acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac      720

ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac      780

cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg      840

agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg      900

tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg      960

agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac     1020

tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg     1080

ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg     1140

tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc     1200

aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc     1260

tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtc cttctagtgt     1320

agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc     1380

taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact     1440

caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac     1500

agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag     1560

aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg     1620

gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg     1680

tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga     1740

gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt     1800

ttgctcacat gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct     1860

ttgagtgagc tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg     1920

aggaagcgga agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt     1980

aatgcagctg gcacgacagg tttcccgact ggaaagcggg cagtgagcgc aacgcaatta     2040

atgtgagtta gctcactcat taggcacccc aggctttaca ctttatgctt ccggctcgta     2100

tgttgtgtgg aattgtgagc ggataacaat ttcacacagg aaacagctat gaccatgatt     2160

acgccaagcg cgcaattaac cctcactaaa gggaacaaaa gctggagctg caagcttaat     2220

gtagtcttat gcaatactct tgtagtcttg caacatggta acgatgagtt agcaacatgc     2280

cttacaagga gagaaaaagc accgtgcatg ccgattggtg gaagtaaggt ggtacgatcg     2340

tgccttatta ggaaggcaac agacgggtct gacatggatt ggacgaacca ctgaattgcc     2400

gcattgcaga gatattgtat ttaagtgcct agctcgatac aataaacggg tctctctggt     2460

tagaccagat ctgagcctgg gagctctctg gctaactagg gaacccactg cttaagcctc     2520

aataaagctt gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt gactctggta     2580

actagagatc cctcagaccc ttttagtcag tgtggaaaat ctctagcagt ggcgcccgaa     2640

cagggacctg aaagcgaaag ggaaaccaga gctctctcga cgcaggactc ggcttgctga     2700

agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa ttttgactag     2760

cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg ggagaattag     2820

atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata aattaaaaca     2880

tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc tgttagaaac     2940

atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga caggatcaga     3000

agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc aaaggataga     3060

gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca aaagtaagac     3120

caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg agggacaatt     3180

ggagaagtga attatataaa tataaagtag taaaaattga accattagga gtagcaccca     3240

ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata ggagctttgt     3300

tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcctcaatg acgctgacgg     3360

tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg ctgagggcta     3420

ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag ctccaggcaa     3480

gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt tggggttgct     3540

ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt aataaatctc     3600

tggaacagat tggaatcaca cgacctggat ggagtgggac agagaaatta acaattacac     3660

aagcttaata cactccttaa ttgaagaatc gcaaaaccag caagaaaaga atgaacaaga     3720

attattggaa ttagataaat gggcaagttt gtggaattgg tttaacataa caaattggct     3780

gtggtatata aaattattca taatgatagt aggaggcttg gtaggtttaa gaatagtttt     3840

tgctgtactt tctatagtga atagagttag gcagggatat tcaccattat cgtttcagac     3900

ccacctccca accccgaggg gacccgacag gcccgaagga atagaagaag aaggtggaga     3960

gagagacaga gacagatcca ttcgattagt gaacggatct cgacggttaa cttttaaaag     4020

aaaagggggg attggggggt acagtgcagg ggaaagaata gtagacataa tagcaacaga     4080

catacaaact aaagaattac aaaaacaaat tacaaaaatt caaaatttta tcgagctttg     4140

caaagatgga taaagtttta aacagagagg aatctttgca gctaatggac cttctaggtc     4200

ttgaaaggag tgcctcgtga ggctccggtg cccgtcagtg ggcagagcgc acatcgccca     4260

cagtccccga gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc     4320

gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg     4380

gagaaccgta tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg     4440

ccagaacaca ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg     4500

gcccttgcgt gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc     4560

ttcgggttgg aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc     4620

gtgcttgagt tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc     4680

ttcgcgcctg tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg     4740

ctgcgacgct ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg     4800

gtatttcggt ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt     4860

cggcgaggcg gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg     4920

gccggcctgc tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa     4980

ggctggcccg gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg     5040

cagggagctc aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac     5100

aaaggaaaag ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg     5160

cgccgtccag gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg     5220

gggaggggtt ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc     5280

cagcttggca cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt     5340

tcattctcaa gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag     5400

gaattcggta ccgcggccgc ccggggatcc atggccttac cagtgaccgc cttgctcctg     5460

ccgctggcct tgctgctcca cgccgccagg ccggacatcc agatgacaca gactacatcc     5520

tccctgtctg cctctctggg agacagagtc accatcagtt gcagggcaag tcaggacatt     5580

agtaaatatt taaattggta tcagcagaaa ccagatggaa ctgttaaact cctgatctac     5640

catacatcaa gattacactc aggagtccca tcaaggttca gtggcagtgg gtctggaaca     5700

gattattctc tcaccattag caacctggag caagaagata ttgccactta cttttgccaa     5760

cagggtaata cgcttccgta cacgttcgga ggggggacca agctggagat cacaggtggc     5820

ggtggctcgg gcggtggtgg gtcgggtggc ggcggatctg aggtgaaact gcaggagtca     5880

ggacctggcc tggtggcgcc ctcacagagc ctgtccgtca catgcactgt ctcaggggtc     5940

tcattacccg actatggtgt aagctggatt cgccagcctc cacgaaaggg tctggagtgg     6000

ctgggagtaa tatggggtag tgaaaccaca tactataatt cagctctcaa atccagactg     6060

accatcatca aggacaactc caagagccaa gttttcttaa aaatgaacag tctgcaaact     6120

gatgacacag ccatttacta ctgtgccaaa cattattact acggtggtag ctatgctatg     6180

gactactggg gccaaggaac ctcagtcacc gtctcctcaa ccacgacgcc agcgccgcga     6240

ccaccaacac cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc     6300

cggccagcgg cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatatctac     6360

atctgggcgc ccttggccgg gacttgtggg gtccttctcc tgtcactggt tatcaccctt     6420

tactgcaaac ggggcagaaa gaaactcctg tatatattca aacaaccatt tatgagacca     6480

gtacaaacta ctcaagagga agatggctgt agctgccgat ttccagaaga agaagaagga     6540

ggatgtgaac tgagagtgaa gttcagcagg agcgcagacg cccccgcgta caagcagggc     6600

cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga tgttttggac     6660

aagagacgtg gccgggaccc tgagatgggg ggaaagccga gaaggaagaa ccctcaggaa     6720

ggcctgtaca atgaactgca gaaagataag atggcggagg cctacagtga gattgggatg     6780

aaaggcgagc gccggagggg caaggggcac gatggccttt accagggtct cagtacagcc     6840

accaaggaca cctacgacgc ccttcacatg caggccctgc cccctcgcta agtcgacaat     6900

caacctctgg attacaaaat ttgtgaaaga ttgactggta ttcttaacta tgttgctcct     6960

tttacgctat gtggatacgc tgctttaatg cctttgtatc atgctattgc ttcccgtatg     7020

gctttcattt tctcctcctt gtataaatcc tggttgctgt ctctttatga ggagttgtgg     7080

cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg ctgacgcaac ccccactggt     7140

tggggcattg ccaccacctg tcagctcctt tccgggactt tcgctttccc cctccctatt     7200

gccacggcgg aactcatcgc cgcctgcctt gcccgctgct ggacaggggc tcggctgttg     7260

ggcactgaca attccgtggt gttgtcgggg aagctgacgt cctttccatg gctgctcgcc     7320

tgtgttgcca cctggattct gcgcgggacg tccttctgct acgtcccttc ggccctcaat     7380

ccagcggacc ttccttcccg cggcctgctg ccggctctgc ggcctcttcc gcgtcttcgc     7440

cttcgccctc agacgagtcg gatctccctt tgggccgcct ccccgcctgg aattcgagct     7500

cggtaccttt aagaccaatg acttacaagg cagctgtaga tcttagccac tttttaaaag     7560

aaaagggggg actggaaggg ctaattcact cccaacgaag acaagatctg ctttttgctt     7620

gtactgggtc tctctggtta gaccagatct gagcctggga gctctctggc taactaggga     7680

acccactgct taagcctcaa taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc     7740

tgttgtgtga ctctggtaac tagagatccc tcagaccctt ttagtcagtg tggaaaatct     7800

ctagcagtag tagttcatgt catcttatta ttcagtattt ataacttgca aagaaatgaa     7860

tatcagagag tgagaggaac ttgtttattg cagcttataa tggttacaaa taaagcaata     7920

gcatcacaaa tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca     7980

aactcatcaa tgtatcttat catgtctggc tctagctatc ccgcccctaa ctccgcccag     8040

ttccgcccat tctccgcccc atggctgact aatttttttt atttatgcag aggccgaggc     8100

cgcctcggcc tctgagctat tccagaagta gtgaggaggc ttttttggag gcctaggctt     8160

ttgcgtcgag acgtacccaa ttcgccctat agtgagtcgt attacgcgcg ctcactggcc     8220

gtcgttttac aacgtcgtga ctgggaaaac cctggcgtta cccaacttaa tcgccttgca     8280

gcacatcccc ctttcgccag ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc     8340

caacagttgc gcagcctgaa tggcgaatgg cgcgacgcgc cctgtagcgg cgcattaagc     8400

gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc     8460

gctcctttcg ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct     8520

ctaaatcggg ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa     8580

aaacttgatt agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc     8640

cctttgacgt tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca     8700

ctcaacccta tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat     8760

tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg     8820

tttacaattt cc                                                         8832


<210>  10
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Light chain of wildtype anti-CS1 antibody

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Ile Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  11
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Heavy chain of wildtype anti-CS1 antibody

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  


Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Asp Gly Asn Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  12
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-Her2-Fab Variable light chain

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  13
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Anti-Her2-Fab Variable heavy chain

<400>  13

Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu 
1               5                   10                  15      


Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Ser Ser Asp Phe Ala 
            20                  25                  30          


Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Tyr Ile Ser Tyr Ser Gly Asn Thr Arg Tyr Gln Pro Ser Leu Lys Ser 
    50                  55                  60                  


Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu Lys 
65                  70                  75                  80  


Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys Val Thr 
                85                  90                  95      


Ala Gly Arg Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  14
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Light chain of anti-BCMA antibody (BCMA98)

<400>  14

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Asn Gln Gly Ile Ser Asn Asn 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Thr Ser Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  15
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Heavy chain of anti-BCMA antibody (BCMA98)

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  16
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD19-Fab Light Chain

<400>  16

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  17
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD19-Fab Heavy Chain

<400>  17

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr 
225             


<210>  18
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CLL1-Fab Variable Light Chain (clone 1075.7)

<400>  18

Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Asn Val Ile Ser Ser 
            20                  25                  30          


Tyr Val His Trp Tyr Gln Gln Arg Ser Gly Ala Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Gly Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105             


<210>  19
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CLL1-Fab Variable Heavy Chain (clone 1075.7)

<400>  19

Asp Ile Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Ala 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Asp Gly Arg Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Gly Asp Tyr Asp Val Gly Asn Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  20
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD33-Fab Variable Light Chain (clone HP67.6)

<400>  20

Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Leu Asp Asn Tyr 
            20                  25                  30          


Gly Ile Arg Phe Leu Thr Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Met Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Lys 
                85                  90                  95      


Glu Val Pro Trp Ser Phe Gly Gln Gly Thr Lys Val Glu Val Lys 
            100                 105                 110     


<210>  21
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - anti- CD33-Fab Variable Heavy Chain (clone HP67.6)

<400>  21

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile Thr Asp Ser 
            20                  25                  30          


Asn Ile His Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asn Arg Ala Thr Leu Thr Val Asp Asn Pro Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Val Asn Gly Asn Pro Trp Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  22
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD33-Fab Variable Light Chain (clone hM195)

<400>  22

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  23
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti- CD33-Fab Variable Heavy Chain (clone hM195)

<400>  23

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Pro Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  24
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD123-Fab Variable Light Chain (clone 32716)

<400>  24

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Asn Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210>  25
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti- CD123-Fab Variable Heavy Chain (clone 32716)

<400>  25

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Ser Phe Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ser Ala Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu His Ile Asn Asp Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  26
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti- CD123-Fab Variable Light Chain (clone 26292)

<400>  26

Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys Asp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn Lys Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  27
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti- CD123-Fab Variable Heavy Chain (clone 26292)

<400>  27

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Asp Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Trp Asp Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  28
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Anti- CD22- Fab Variable Heavy Chain (clone M971)

<400>  28

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Trp Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Gln 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105     


<210>  29
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - Anti- CD22- Fab Variable Light Chain (clone M971)

<400>  29

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Glu Val Thr Gly Asp Leu Glu Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala 
        115                 120                 125 


<210>  30
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Anti- CD22- Fab Variable Heavy Chain (clone hLL2)

<400>  30

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ala Asn His Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Leu Ser Ser Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  31
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Anti- CD22- Fab Variable Light Chain (clone hLL2)

<400>  31

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Arg Asn Asp Tyr Thr Glu Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Phe Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Asp Ile Thr Thr Phe Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  32
<211>  6102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in lab - NYESO1(1G4-113)-TCRb-WT

<400>  32
atccggatat agttcctcct ttcagcaaaa aacccctcaa gacccgttta gaggccccaa       60

ggggttatgc tagttattgc tcagcggtgg cagcagccaa ctcagcttcc tttcgggctt      120

tgttagcagc cggatctcag tggtggtggt ggtggtgctc gagttagtca gcacgacccc      180

acgcttctgc actgacaatt tgcgtaaccg gttttgcacg gtcctgggtc cattcatcat      240

tttcgctcag gccgtagaat tgaacctgac agcgaaaatg gttacgcggg tcctgccaga      300

aggtggcaga cacgcgcaga cgggaactca gggcataacg gctgtcattc agcgccggtt      360

gttctttcag cggctgcgga tcggtacaca cacccgagtg gacttctttg ccgttcaccc      420

accatgacag ttcgacatgg tccggataaa agccggtggc caggcacacc agcgtcgctt      480

tctgggtatg ggagatttca gcttcactcg gttcgaaaac tgccacttcc ggcggaaaga      540

catttttcag atcttccaga accgtcagac gagaaccttc gccgaaaaac agttcaccgg      600

tgttgcccag gtaagagctt gcgcagaaat aaacagacgt ttggctcggt gctgcgctca      660

gcagacgcag cggaaagtct tcaatggtcg aacgtgaaac attgtaaccg ttcggcactt      720

cgccttgatc cgtggtctgg atggcgaccg aatagtgaat cagacgcaga cccatacccg      780

ggtcctgacg gtaccatgac atatattcat ggttcatatc ttgggcacat tgcagcgtca      840

tggattggcc cgttttcagg acttggaatt tcggcgtttg ggtcacacca gcgttcatat      900

gtatatctcc ttcttaaagt taaacaaaat tatttctaga ggggaattgt tatccgctca      960

caattcccct atagtgagtc gtattaattt cgcgggatcg agatctcgat cctctacgcc     1020

ggacgcatcg tggccggcat caccggcgcc acaggtgcgg ttgctggcgc ctatatcgcc     1080

gacatcaccg atggggaaga tcgggctcgc cacttcgggc tcatgagcgc ttgtttcggc     1140

gtgggtatgg tggcaggccc cgtggccggg ggactgttgg gcgccatctc cttgcatgca     1200

ccattccttg cggcggcggt gctcaacggc ctcaacctac tactgggctg cttcctaatg     1260

caggagtcgc ataagggaga gcgtcgagat cccggacacc atcgaatggc gcaaaacctt     1320

tcgcggtatg gcatgatagc gcccggaaga gagtcaattc agggtggtga atgtgaaacc     1380

agtaacgtta tacgatgtcg cagagtatgc cggtgtctct tatcagaccg tttcccgcgt     1440

ggtgaaccag gccagccacg tttctgcgaa aacgcgggaa aaagtggaag cggcgatggc     1500

ggagctgaat tacattccca accgcgtggc acaacaactg gcgggcaaac agtcgttgct     1560

gattggcgtt gccacctcca gtctggccct gcacgcgccg tcgcaaattg tcgcggcgat     1620

taaatctcgc gccgatcaac tgggtgccag cgtggtggtg tcgatggtag aacgaagcgg     1680

cgtcgaagcc tgtaaagcgg cggtgcacaa tcttctcgcg caacgcgtca gtgggctgat     1740

cattaactat ccgctggatg accaggatgc cattgctgtg gaagctgcct gcactaatgt     1800

tccggcgtta tttcttgatg tctctgacca gacacccatc aacagtatta ttttctccca     1860

tgaagacggt acgcgactgg gcgtggagca tctggtcgca ttgggtcacc agcaaatcgc     1920

gctgttagcg ggcccattaa gttctgtctc ggcgcgtctg cgtctggctg gctggcataa     1980

atatctcact cgcaatcaaa ttcagccgat agcggaacgg gaaggcgact ggagtgccat     2040

gtccggtttt caacaaacca tgcaaatgct gaatgagggc atcgttccca ctgcgatgct     2100

ggttgccaac gatcagatgg cgctgggcgc aatgcgcgcc attaccgagt ccgggctgcg     2160

cgttggtgcg gatatctcgg tagtgggata cgacgatacc gaagacagct catgttatat     2220

cccgccgtta accaccatca aacaggattt tcgcctgctg gggcaaacca gcgtggaccg     2280

cttgctgcaa ctctctcagg gccaggcggt gaagggcaat cagctgttgc ccgtctcact     2340

ggtgaaaaga aaaaccaccc tggcgcccaa tacgcaaacc gcctctcccc gcgcgttggc     2400

cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca     2460

acgcaattaa tgtaagttag ctcactcatt aggcaccggg atctcgaccg atgcccttga     2520

gagccttcaa cccagtcagc tccttccggt gggcgcgggg catgactatc gtcgccgcac     2580

ttatgactgt cttctttatc atgcaactcg taggacaggt gccggcagcg ctctgggtca     2640

ttttcggcga ggaccgcttt cgctggagcg cgacgatgat cggcctgtcg cttgcggtat     2700

tcggaatctt gcacgccctc gctcaagcct tcgtcactgg tcccgccacc aaacgtttcg     2760

gcgagaagca ggccattatc gccggcatgg cggccccacg ggtgcgcatg atcgtgctcc     2820

tgtcgttgag gacccggcta ggctggcggg gttgccttac tggttagcag aatgaatcac     2880

cgatacgcga gcgaacgtga agcgactgct gctgcaaaac gtctgcgacc tgagcaacaa     2940

catgaatggt cttcggtttc cgtgtttcgt aaagtctgga aacgcggaag tcagcgccct     3000

gcaccattat gttccggatc tgcatcgcag gatgctgctg gctaccctgt ggaacaccta     3060

catctgtatt aacgaagcgc tggcattgac cctgagtgat ttttctctgg tcccgccgca     3120

tccataccgc cagttgttta ccctcacaac gttccagtaa ccgggcatgt tcatcatcag     3180

taacccgtat cgtgagcatc ctctctcgtt tcatcggtat cattaccccc atgaacagaa     3240

atccccctta cacggaggca tcagtgacca aacaggaaaa aaccgccctt aacatggccc     3300

gctttatcag aagccagaca ttaacgcttc tggagaaact caacgagctg gacgcggatg     3360

aacaggcaga catctgtgaa tcgcttcacg accacgctga tgagctttac cgcagctgcc     3420

tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca     3480

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg     3540

ttggcgggtg tcggggcgca gccatgaccc agtcacgtag cgatagcgga gtgtatactg     3600

gcttaactat gcggcatcag agcagattgt actgagagtg caccatatat gcggtgtgaa     3660

ataccgcaca gatgcgtaag gagaaaatac cgcatcaggc gctcttccgc ttcctcgctc     3720

actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg     3780

gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc     3840

cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc     3900

ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga     3960

ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc     4020

ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat     4080

agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg     4140

cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc     4200

aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga     4260

gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact     4320

agaaggacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt     4380

ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag     4440

cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg     4500

tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa     4560

aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata     4620

tatgagtaaa cttggtctga cagttaccaa tgcttaatca gtgaggcacc tatctcagcg     4680

atctgtctat ttcgttcatc catagttgcc tgactccccg tcgtgtagat aactacgata     4740

cgggagggct taccatctgg ccccagtgct gcaatgatac cgcgagaccc acgctcaccg     4800

gctccagatt tatcagcaat aaaccagcca gccggaaggg ccgagcgcag aagtggtcct     4860

gcaactttat ccgcctccat ccagtctatt aattgttgcc gggaagctag agtaagtagt     4920

tcgccagtta atagtttgcg caacgttgtt gccattgctg caggcatcgt ggtgtcacgc     4980

tcgtcgtttg gtatggcttc attcagctcc ggttcccaac gatcaaggcg agttacatga     5040

tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt tgtcagaagt     5100

aagttggccg cagtgttatc actcatggtt atggcagcac tgcataattc tcttactgtc     5160

atgccatccg taagatgctt ttctgtgact ggtgagtact caaccaagtc attctgagaa     5220

tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca     5280

catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg aaaactctca     5340

aggatcttac cgctgttgag atccagttcg atgtaaccca ctcgtgcacc caactgatct     5400

tcagcatctt ttactttcac cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc     5460

gcaaaaaagg gaataagggc gacacggaaa tgttgaatac tcatactctt cctttttcaa     5520

tattattgaa gcatttatca gggttattgt ctcatgagcg gatacatatt tgaatgtatt     5580

tagaaaaata aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc acctgaaatt     5640

gtaaacgtta atattttgtt aaaattcgcg ttaaattttt gttaaatcag ctcatttttt     5700

aaccaatagg ccgaaatcgg caaaatccct tataaatcaa aagaatagac cgagataggg     5760

ttgagtgttg ttccagtttg gaacaagagt ccactattaa agaacgtgga ctccaacgtc     5820

aaagggcgaa aaaccgtcta tcagggcgat ggcccactac gtgaaccatc accctaatca     5880

agttttttgg ggtcgaggtg ccgtaaagca ctaaatcgga accctaaagg gagcccccga     5940

tttagagctt gacggggaaa gccggcgaac gtggcgagaa aggaagggaa gaaagcgaaa     6000

ggagcgggcg ctagggcgct ggcaagtgta gcggtcacgc tgcgcgtaac caccacaccc     6060

gccgcgctta atgcgccgct acagggcgcg tcccattcgc ca                        6102


<210>  33
<211>  5997
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - NYESO1(1G4-113)-TCRa-WT

<400>  33
atccggatat agttcctcct ttcagcaaaa aacccctcaa gacccgttta gaggccccaa       60

ggggttatgc tagttattgc tcagcggtgg cagcagccaa ctcagcttcc tttcgggctt      120

tgttagcagc cggatctcag tggtggtggt ggtggtgctc gagttaagag ctttccgggc      180

tcgggaaaaa cgtatcttcc gggataatac tattgttgaa tgcgttggcg cacgcaaagt      240

cagatttatt gctccaagca actgccgagt ttgatttgaa atccatagag cgcatgtcca      300

gaacacattt atcggtaata tacacgtcgg aatctttgga ttgactgaca ttcgtctgac      360

tgtcgaaatc ggtaaacagg cacacgcttt tgtccgatga tttgctatca cgcagttggt      420

acaccgccgg gtccgggttc tggatatacg gatggacaat caggctggta ccgcggccaa      480

acgtcgggat ataggtacca tccagcagcg gacgcaccgc acacaggtac gtagcggagt      540

cacccggctg acttgctgca atatacaggg tggaactacc agagctttta tccagcgatg      600

cattcaggcg gcctgaggtt tgttcacgct gccacggcgt gatcagcagc aggctggtca      660

gacctttgcc cggatcttga cgaaaccact gcaggttgta aatggcgcta tccgtaaagg      720

agcaattcag caccagattt tcaccttccg ggaccgacag agcagccggg atttgggtaa      780

cttcttgttt catatgtata tctccttctt aaagttaaac aaaattattt ctagagggga      840

attgttatcc gctcacaatt cccctatagt gagtcgtatt aatttcgcgg gatcgagatc      900

tcgatcctct acgccggacg catcgtggcc ggcatcaccg gcgccacagg tgcggttgct      960

ggcgcctata tcgccgacat caccgatggg gaagatcggg ctcgccactt cgggctcatg     1020

agcgcttgtt tcggcgtggg tatggtggca ggccccgtgg ccgggggact gttgggcgcc     1080

atctccttgc atgcaccatt ccttgcggcg gcggtgctca acggcctcaa cctactactg     1140

ggctgcttcc taatgcagga gtcgcataag ggagagcgtc gagatcccgg acaccatcga     1200

atggcgcaaa acctttcgcg gtatggcatg atagcgcccg gaagagagtc aattcagggt     1260

ggtgaatgtg aaaccagtaa cgttatacga tgtcgcagag tatgccggtg tctcttatca     1320

gaccgtttcc cgcgtggtga accaggccag ccacgtttct gcgaaaacgc gggaaaaagt     1380

ggaagcggcg atggcggagc tgaattacat tcccaaccgc gtggcacaac aactggcggg     1440

caaacagtcg ttgctgattg gcgttgccac ctccagtctg gccctgcacg cgccgtcgca     1500

aattgtcgcg gcgattaaat ctcgcgccga tcaactgggt gccagcgtgg tggtgtcgat     1560

ggtagaacga agcggcgtcg aagcctgtaa agcggcggtg cacaatcttc tcgcgcaacg     1620

cgtcagtggg ctgatcatta actatccgct ggatgaccag gatgccattg ctgtggaagc     1680

tgcctgcact aatgttccgg cgttatttct tgatgtctct gaccagacac ccatcaacag     1740

tattattttc tcccatgaag acggtacgcg actgggcgtg gagcatctgg tcgcattggg     1800

tcaccagcaa atcgcgctgt tagcgggccc attaagttct gtctcggcgc gtctgcgtct     1860

ggctggctgg cataaatatc tcactcgcaa tcaaattcag ccgatagcgg aacgggaagg     1920

cgactggagt gccatgtccg gttttcaaca aaccatgcaa atgctgaatg agggcatcgt     1980

tcccactgcg atgctggttg ccaacgatca gatggcgctg ggcgcaatgc gcgccattac     2040

cgagtccggg ctgcgcgttg gtgcggatat ctcggtagtg ggatacgacg ataccgaaga     2100

cagctcatgt tatatcccgc cgttaaccac catcaaacag gattttcgcc tgctggggca     2160

aaccagcgtg gaccgcttgc tgcaactctc tcagggccag gcggtgaagg gcaatcagct     2220

gttgcccgtc tcactggtga aaagaaaaac caccctggcg cccaatacgc aaaccgcctc     2280

tccccgcgcg ttggccgatt cattaatgca gctggcacga caggtttccc gactggaaag     2340

cgggcagtga gcgcaacgca attaatgtaa gttagctcac tcattaggca ccgggatctc     2400

gaccgatgcc cttgagagcc ttcaacccag tcagctcctt ccggtgggcg cggggcatga     2460

ctatcgtcgc cgcacttatg actgtcttct ttatcatgca actcgtagga caggtgccgg     2520

cagcgctctg ggtcattttc ggcgaggacc gctttcgctg gagcgcgacg atgatcggcc     2580

tgtcgcttgc ggtattcgga atcttgcacg ccctcgctca agccttcgtc actggtcccg     2640

ccaccaaacg tttcggcgag aagcaggcca ttatcgccgg catggcggcc ccacgggtgc     2700

gcatgatcgt gctcctgtcg ttgaggaccc ggctaggctg gcggggttgc cttactggtt     2760

agcagaatga atcaccgata cgcgagcgaa cgtgaagcga ctgctgctgc aaaacgtctg     2820

cgacctgagc aacaacatga atggtcttcg gtttccgtgt ttcgtaaagt ctggaaacgc     2880

ggaagtcagc gccctgcacc attatgttcc ggatctgcat cgcaggatgc tgctggctac     2940

cctgtggaac acctacatct gtattaacga agcgctggca ttgaccctga gtgatttttc     3000

tctggtcccg ccgcatccat accgccagtt gtttaccctc acaacgttcc agtaaccggg     3060

catgttcatc atcagtaacc cgtatcgtga gcatcctctc tcgtttcatc ggtatcatta     3120

cccccatgaa cagaaatccc ccttacacgg aggcatcagt gaccaaacag gaaaaaaccg     3180

cccttaacat ggcccgcttt atcagaagcc agacattaac gcttctggag aaactcaacg     3240

agctggacgc ggatgaacag gcagacatct gtgaatcgct tcacgaccac gctgatgagc     3300

tttaccgcag ctgcctcgcg cgtttcggtg atgacggtga aaacctctga cacatgcagc     3360

tcccggagac ggtcacagct tgtctgtaag cggatgccgg gagcagacaa gcccgtcagg     3420

gcgcgtcagc gggtgttggc gggtgtcggg gcgcagccat gacccagtca cgtagcgata     3480

gcggagtgta tactggctta actatgcggc atcagagcag attgtactga gagtgcacca     3540

tatatgcggt gtgaaatacc gcacagatgc gtaaggagaa aataccgcat caggcgctct     3600

tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca     3660

gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac     3720

atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt     3780

ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg     3840

cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc     3900

tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc     3960

gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc     4020

aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac     4080

tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt     4140

aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct     4200

aactacggct acactagaag gacagtattt ggtatctgcg ctctgctgaa gccagttacc     4260

ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt     4320

ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg     4380

atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc     4440

atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa     4500

tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag     4560

gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg     4620

tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga     4680

gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag     4740

cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa     4800

gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctgcaggc     4860

atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca     4920

aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg     4980

atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat     5040

aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc     5100

aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg     5160

gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg     5220

gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt     5280

gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca     5340

ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata     5400

ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac     5460

atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa     5520

gtgccacctg aaattgtaaa cgttaatatt ttgttaaaat tcgcgttaaa tttttgttaa     5580

atcagctcat tttttaacca ataggccgaa atcggcaaaa tcccttataa atcaaaagaa     5640

tagaccgaga tagggttgag tgttgttcca gtttggaaca agagtccact attaaagaac     5700

gtggactcca acgtcaaagg gcgaaaaacc gtctatcagg gcgatggccc actacgtgaa     5760

ccatcaccct aatcaagttt tttggggtcg aggtgccgta aagcactaaa tcggaaccct     5820

aaagggagcc cccgatttag agcttgacgg ggaaagccgg cgaacgtggc gagaaaggaa     5880

gggaagaaag cgaaaggagc gggcgctagg gcgctggcaa gtgtagcggt cacgctgcgc     5940

gtaaccacca cacccgccgc gcttaatgcg ccgctacagg gcgcgtccca ttcgcca        5997


<210>  34
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence - CD8 hinge peptide

<400>  34

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  35

<400>  35
000

<210>  36
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence - IgG4 hinge peptide

<400>  36

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
1               5                   10          


<210>  37
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence - IgG4 m hinge peptide

<400>  37

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10          


<210>  38
<211>  4206
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - mCD19(1D3)-LC-WT (wild type light chain sequence)

<400>  38
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa cgggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacctgaga tcaccggcga aggagggcca ccatgtacag gatgcaactc ctgtcttgca      600

ttgcactaag tcttgcactt gtcacgaatt cggacattca gctgacccag tctccagctt      660

ccctgtctac atctctggga gaaactgtca ccatccaatg tcaagcaagt gaggacattt      720

acagtggttt agcgtggtat cagcagaagc cagggaaatc tcctcagctc ctgatctatg      780

gtgcaagtga cttacaagac ggcgtcccat cacgattcag tggcagtgga tctggcacac      840

agtattctct caagatcacc agcatgcaaa ctgaagatga aggggtttat ttctgtcaac      900

agggtttaac gtatcctcgg acgttcggtg gcggcaccaa gctggaaatc aaacgaactg      960

tggctgcacc atctgtcttc atcttcccgc catctgatga gcagttgaaa tctggaactg     1020

cctctgtcgt gtgcctgctg aataacttct atcccagaga ggccaaagta cagtggaagg     1080

tggataacgc cctccaatcg ggtaactccc aggagagtgt cacagagcag gacagcggcg     1140

gaggcgggag caattatcat cttgaaaatg aggtcgctcg tctcaagaaa ctcggtggcg     1200

gaggcagcga cagcacctac agcctcagca gcaccctgac gcttagcaaa gcagactacg     1260

agaaacacaa agtctacgcc tgcgaagtca cccatcaggg cctgtcctcg cccgtcacaa     1320

agagcttcaa caggggagag tgttgataag tgctagctgg ccagacatga taagatacat     1380

tgatgagttt ggacaaacca caactagaat gcagtgaaaa aaatgcttta tttgtgaaat     1440

ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag ttaacaacaa     1500

caattgcatt cattttatgt ttcaggttca gggggaggtg tgggaggttt tttaaagcaa     1560

gtaaaacctc tacaaatgtg gtatggaatt aattctaaaa tacagcatag caaaacttta     1620

acctccaaat caagcctcta cttgaatcct tttctgaggg atgaataagg cataggcatc     1680

aggggctgtt gccaatgtgc attagctgtt tgcagcctca ccttctttca tggagtttaa     1740

gatatagtgt attttcccaa ggtttgaact agctcttcat ttctttatgt tttaaatgca     1800

ctgacctccc acattccctt tttagtaaaa tattcagaaa taatttaaat acatcattgc     1860

aatgaaaata aatgtttttt attaggcaga atccagatgc tcaaggccct tcataatatc     1920

ccccagttta gtagttggac ttagggaaca aaggaacctt taatagaaat tggacagcaa     1980

gaaagcgagc ttctagctta tcctcagtcc tgctcctctg ccacaaagtg cacgcagttg     2040

ccggccgggt cgcgcagggc gaactcccgc ccccacggct gctcgccgat ctcggtcatg     2100

gccggcccgg aggcgtcccg gaagttcgtg gacacgacct ccgaccactc ggcgtacagc     2160

tcgtccaggc cgcgcaccca cacccaggcc agggtgttgt ccggcaccac ctggtcctgg     2220

accgcgctga tgaacagggt cacgtcgtcc cggaccacac cggcgaagtc gtcctccacg     2280

aagtcccggg agaacccgag ccggtcggtc cagaactcga ccgctccggc gacgtcgcgc     2340

gcggtgagca ccggaacggc actggtcaac ttggccatga tggctcctcc tgtcaggaga     2400

ggaaagagaa gaaggttagt acaattgcta tagtgagttg tattatacta tgcagatata     2460

ctatgccaat gattaattgt caaactaggg ctgcagggtt catagtgcca cttttcctgc     2520

actgccccat ctcctgccca ccctttccca ggcatagaca gtcagtgact taccaaactc     2580

acaggaggga gaaggcagaa gcttgagaca gacccgcggg accgccgaac tgcgagggga     2640

cgtggctagg gcggcttctt ttatggtgcg ccggccctcg gaggcagggc gctcggggag     2700

gcctagcggc caatctgcgg tggcaggagg cggggccgaa ggccgtgcct gaccaatccg     2760

gagcacatag gagtctcagc cccccgcccc aaagcaaggg gaagtcacgc gcctgtagcg     2820

ccagcgtgtt gtgaaatggg ggcttggggg ggttggggcc ctgactagtc aaaacaaact     2880

cccattgacg tcaatggggt ggagacttgg aaatccccgt gagtcaaacc gctatccacg     2940

cccattgatg tactgccaaa accgcatcat catggtaata gcgatgacta atacgtagat     3000

gtactgccaa gtaggaaagt cccataaggt catgtactgg gcataatgcc aggcgggcca     3060

tttaccgtca ttgacgtcaa tagggggcgt acttggcata tgatacactt gatgtactgc     3120

caagtgggca gtttaccgta aatactccac ccattgacgt caatggaaag tccctattgg     3180

cgttactatg ggaacatacg tcattattga cgtcaatggg cgggggtcgt tgggcggtca     3240

gccaggcggg ccatttaccg taagttatgt aacgcctgca ggttaattaa gaacatgtga     3300

gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc gtttttccat     3360

aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac     3420

ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt gcgctctcct     3480

gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg aagcgtggcg     3540

ctttctcata gctcacgctg taggtatctc agttcggtgt aggtcgttcg ctccaagctg     3600

ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg ccttatccgg taactatcgt     3660

cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg     3720

attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac     3780

ggctacacta gaagaacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga     3840

aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg tggttttttt     3900

gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt     3960

tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatggct     4020

agttaattaa catttaaatc agcggccgca ataaaatatc tttattttca ttacatctgt     4080

gtgttggttt tttgtgtgaa tcgtaactaa catacgctct ccatcaaaac aaaacgaaac     4140

aaaacaaact agcaaaatag gctgtcccca gtgcaagtgc aggtgccaga acatttctct     4200

atcgaa                                                                4206


<210>  39
<211>  4137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - mCD19(1D3)-HC-WT Fab (wild type heavy chain 
       sequence)

<400>  39
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa cgggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacctgaga tcaccggcga aggagggcca ccatgtacag gatgcaactc ctgtcttgca      600

ttgcactaag tcttgcactt gtcacgaatt cggacattca gctgacccag tctccagctt      660

ccctgtctac atctctggga gaaactgtca ccatccaatg tcaagcaagt gaggacattt      720

acagtggttt agcgtggtat cagcagaagc cagggaaatc tcctcagctc ctgatctatg      780

gtgcaagtga cttacaagac ggcgtcccat cacgattcag tggcagtgga tctggcacac      840

agtattctct caagatcacc agcatgcaaa ctgaagatga aggggtttat ttctgtcaac      900

agggtttaac gtatcctcgg acgttcggtg gcggcaccaa gctggaaatc aaacgaactg      960

tggctgcacc atctgtcttc atcttcccgc catctgatga gcagttgaaa tctggaactg     1020

cctctgtcgt gtgcctgctg aataacttct atcccagaga ggccaaagta cagtggaagg     1080

tggataacgc cctccaatcg ggtaactccc aggagagtgt cacagagcag gacagcaagg     1140

acagcaccta cagcctcagc agcaccctga cgctgagcaa agcagactac gagaaacaca     1200

aagtctacgc ctgcgaagtc acccatcagg gcctgtcctc gcccgtcaca aagagcttca     1260

acaggggaga gtgttgataa gtgctagctg gccagacatg ataagataca ttgatgagtt     1320

tggacaaacc acaactagaa tgcagtgaaa aaaatgcttt atttgtgaaa tttgtgatgc     1380

tattgcttta tttgtaacca ttataagctg caataaacaa gttaacaaca acaattgcat     1440

tcattttatg tttcaggttc agggggaggt gtgggaggtt ttttaaagca agtaaaacct     1500

ctacaaatgt ggtatggaat taattctaaa atacagcata gcaaaacttt aacctccaaa     1560

tcaagcctct acttgaatcc ttttctgagg gatgaataag gcataggcat caggggctgt     1620

tgccaatgtg cattagctgt ttgcagcctc accttctttc atggagttta agatatagtg     1680

tattttccca aggtttgaac tagctcttca tttctttatg ttttaaatgc actgacctcc     1740

cacattccct ttttagtaaa atattcagaa ataatttaaa tacatcattg caatgaaaat     1800

aaatgttttt tattaggcag aatccagatg ctcaaggccc ttcataatat cccccagttt     1860

agtagttgga cttagggaac aaaggaacct ttaatagaaa ttggacagca agaaagcgag     1920

cttctagctt atcctcagtc ctgctcctct gccacaaagt gcacgcagtt gccggccggg     1980

tcgcgcaggg cgaactcccg cccccacggc tgctcgccga tctcggtcat ggccggcccg     2040

gaggcgtccc ggaagttcgt ggacacgacc tccgaccact cggcgtacag ctcgtccagg     2100

ccgcgcaccc acacccaggc cagggtgttg tccggcacca cctggtcctg gaccgcgctg     2160

atgaacaggg tcacgtcgtc ccggaccaca ccggcgaagt cgtcctccac gaagtcccgg     2220

gagaacccga gccggtcggt ccagaactcg accgctccgg cgacgtcgcg cgcggtgagc     2280

accggaacgg cactggtcaa cttggccatg atggctcctc ctgtcaggag aggaaagaga     2340

agaaggttag tacaattgct atagtgagtt gtattatact atgcagatat actatgccaa     2400

tgattaattg tcaaactagg gctgcagggt tcatagtgcc acttttcctg cactgcccca     2460

tctcctgccc accctttccc aggcatagac agtcagtgac ttaccaaact cacaggaggg     2520

agaaggcaga agcttgagac agacccgcgg gaccgccgaa ctgcgagggg acgtggctag     2580

ggcggcttct tttatggtgc gccggccctc ggaggcaggg cgctcgggga ggcctagcgg     2640

ccaatctgcg gtggcaggag gcggggccga aggccgtgcc tgaccaatcc ggagcacata     2700

ggagtctcag ccccccgccc caaagcaagg ggaagtcacg cgcctgtagc gccagcgtgt     2760

tgtgaaatgg gggcttgggg gggttggggc cctgactagt caaaacaaac tcccattgac     2820

gtcaatgggg tggagacttg gaaatccccg tgagtcaaac cgctatccac gcccattgat     2880

gtactgccaa aaccgcatca tcatggtaat agcgatgact aatacgtaga tgtactgcca     2940

agtaggaaag tcccataagg tcatgtactg ggcataatgc caggcgggcc atttaccgtc     3000

attgacgtca atagggggcg tacttggcat atgatacact tgatgtactg ccaagtgggc     3060

agtttaccgt aaatactcca cccattgacg tcaatggaaa gtccctattg gcgttactat     3120

gggaacatac gtcattattg acgtcaatgg gcgggggtcg ttgggcggtc agccaggcgg     3180

gccatttacc gtaagttatg taacgcctgc aggttaatta agaacatgtg agcaaaaggc     3240

cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc     3300

ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga     3360

ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc     3420

ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat     3480

agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg     3540

cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc     3600

aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga     3660

gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact     3720

agaagaacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt     3780

ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag     3840

cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg     3900

tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatggc tagttaatta     3960

acatttaaat cagcggccgc aataaaatat ctttattttc attacatctg tgtgttggtt     4020

ttttgtgtga atcgtaacta acatacgctc tccatcaaaa caaaacgaaa caaaacaaac     4080

tagcaaaata ggctgtcccc agtgcaagtg caggtgccag aacatttctc tatcgaa        4137


<210>  40
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-Her2 Fab wild type light chain

<400>  40

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  41
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - anti-Her2 Fab wild type heavy chain

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr 
225             


<210>  42
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-Her2 Fab (G68X) Light chain


<220>
<221>  MOD_RES
<222>  (68)..(68)
<223>  Xaa = p-acetylphenylalanine (pAcF)

<400>  42

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Xaa Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  43
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-Her2 Fab (S202X) light chain


<220>
<221>  MOD_RES
<222>  (202)..(202)
<223>  Xaa = p-acetylphenylalanine (pAcF)

<400>  43

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Xaa Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  44
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-Her2 Fab (S75X) heavy chain


<220>
<221>  MOD_RES
<222>  (75)..(75)
<223>  Xaa = p-acetylphenylalanine (pAcF)

<400>  44

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Xaa Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr 
225             


<210>  45
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-Her2 Fab (K136X) heavy chain


<220>
<221>  MOD_RES
<222>  (136)..(136)
<223>  Xaa = p-acetylphenylalanine (pAcF)

<400>  45

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Xaa Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr 
225             


<210>  46

<400>  46
000

<210>  47

<400>  47
000

<210>  48
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR-Her2 (CD8 hinge)

<400>  48

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr 
                165                 170                 175     


Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly 
    210                 215                 220                 


Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser Ala Ala Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro 
                245                 250                 255     


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
            260                 265                 270         


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
        275                 280                 285             


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
    290                 295                 300                 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
305                 310                 315                 320 


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
                325                 330                 335     


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
            340                 345                 350         


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
        355                 360                 365             


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
    370                 375                 380                 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
385                 390                 395                 400 


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
                405                 410                 415     


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
            420                 425                 430         


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
        435                 440                 445             


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
    450                 455                 460                 


Gln Ala Leu Pro Pro Arg 
465                 470 


<210>  49
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR-Her2 (IgG4m hinge)

<400>  49

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr 
                165                 170                 175     


Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly 
    210                 215                 220                 


Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser Ala Ala Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
                245                 250                 255     


Pro Cys Pro Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
            260                 265                 270         


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
        275                 280                 285             


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
    290                 295                 300                 


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
305                 310                 315                 320 


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
                325                 330                 335     


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
            340                 345                 350         


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
        355                 360                 365             


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
    370                 375                 380                 


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
385                 390                 395                 400 


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
                405                 410                 415     


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
            420                 425                 430         


Gln Ala Leu Pro Pro Arg 
        435             


<210>  50
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR-FITC (CD8 hinge)

<400>  50

Gln Val Gln Leu Val Glu Ser Gly Gly Asn Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Phe 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Gly Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Leu Ser Ala Arg Ser Ser Leu Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Tyr Asp Ser Ser Gly Tyr Trp Gly His Phe Tyr Ser 
            100                 105                 110         


Tyr Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Val Leu 
    130                 135                 140                 


Thr Gln Pro Ser Ser Val Ser Ala Ala Pro Gly Gln Lys Val Thr Ile 
145                 150                 155                 160 


Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Asn Asn Tyr Val Ser Trp 
                165                 170                 175     


Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp Val 
            180                 185                 190         


Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser 
        195                 200                 205             


Gly Asn Ser Ala Ser Leu Asp Ile Ser Gly Leu Gln Ser Glu Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Glu Phe Leu 
225                 230                 235                 240 


Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Thr Thr Thr Pro Ala 
                245                 250                 255     


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
            260                 265                 270         


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
        275                 280                 285             


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
    290                 295                 300                 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
305                 310                 315                 320 


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
                325                 330                 335     


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            340                 345                 350         


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
        355                 360                 365             


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
385                 390                 395                 400 


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
                405                 410                 415     


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
            420                 425                 430         


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
        435                 440                 445             


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
    450                 455                 460                 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 


<210>  51
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR-FITC (IgG4m hinge)

<400>  51

Gln Val Gln Leu Val Glu Ser Gly Gly Asn Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Phe 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Gly Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Leu Ser Ala Arg Ser Ser Leu Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Tyr Asp Ser Ser Gly Tyr Trp Gly His Phe Tyr Ser 
            100                 105                 110         


Tyr Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Val Leu 
    130                 135                 140                 


Thr Gln Pro Ser Ser Val Ser Ala Ala Pro Gly Gln Lys Val Thr Ile 
145                 150                 155                 160 


Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Asn Asn Tyr Val Ser Trp 
                165                 170                 175     


Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp Val 
            180                 185                 190         


Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser 
        195                 200                 205             


Gly Asn Ser Ala Ser Leu Asp Ile Ser Gly Leu Gln Ser Glu Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Glu Phe Leu 
225                 230                 235                 240 


Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Glu Ser Lys Tyr Gly 
                245                 250                 255     


Pro Pro Cys Pro Pro Cys Pro Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
            260                 265                 270         


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
        275                 280                 285             


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
    290                 295                 300                 


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
305                 310                 315                 320 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
                325                 330                 335     


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
            340                 345                 350         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
        355                 360                 365             


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
    370                 375                 380                 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
385                 390                 395                 400 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                405                 410                 415     


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
            420                 425                 430         


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440         


<210>  52
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab Heavy Chain

<400>  52

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
            100                 105             


<210>  53
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab Light Chain

<400>  53

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


