                         SEQUENCE LISTING

<110>  Alder Biopharmaceuticals, Inc.
 
<120>  ANTI-PACAP ANTIBODIES AND USES THEREOF

<130>  43257.5809

<160>  1246   

<170>  PatentIn version 3.5

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<210>  401
<211>  439
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  401

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Asn Ser Tyr Tyr 
            20                  25                  30          


Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Phe Ile Asp Ala Gly Gly Asp Ala Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Leu 
                85                  90                  95      


Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
            100                 105                 110         


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
        115                 120                 125             


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
    130                 135                 140                 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
145                 150                 155                 160 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
                165                 170                 175     


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
            180                 185                 190         


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala Arg Val Glu 
        195                 200                 205             


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    210                 215                 220                 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
225                 230                 235                 240 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                245                 250                 255     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            260                 265                 270         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        275                 280                 285             


Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    290                 295                 300                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
305                 310                 315                 320 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                325                 330                 335     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            340                 345                 350         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        355                 360                 365             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    370                 375                 380                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
385                 390                 395                 400 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                405                 410                 415     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            420                 425                 430         


Leu Ser Leu Ser Pro Gly Lys 
        435                 


<210>  402
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  402

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Asn Ser Tyr Tyr 
            20                  25                  30          


Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Phe Ile Asp Ala Gly Gly Asp Ala Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Leu 
                85                  90                  95      


Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 


<210>  403
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  403

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Asn 
            20                  25                  


<210>  404
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  404

Ser Tyr Tyr Met Thr 
1               5   


<210>  405
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  405

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  406
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  406

Phe Ile Asp Ala Gly Gly Asp Ala Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  407
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  407

Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
1               5                   10                  15      


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  408
<211>  4
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  408

Asp Leu Asp Leu 
1               


<210>  409
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  409

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  410
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  410

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  411
<211>  1317
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  411
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggaatcga cctcaatagc tactacatga cctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggattcatt gatgctggtg gtgacgcata ctacgcgagc      180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatcacc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gagatcttga cttgtggggc      300

cagggcaccc tggtcaccgt ctcgagcgcc tccaccaagg gcccatcggt cttccccctg      360

gcaccctcct ccaagagcac ctctgggggc acagcggccc tgggctgcct ggtcaaggac      420

tacttccccg aaccggtgac ggtgtcgtgg aactcaggcg ccctgaccag cggcgtgcac      480

accttcccgg ctgtcctaca gtcctcagga ctctactccc tcagcagcgt ggtgaccgtg      540

ccctccagca gcttgggcac ccagacctac atctgcaacg tgaatcacaa gcccagcaac      600

accaaggtgg acgcgagagt tgagcccaaa tcttgtgaca aaactcacac atgcccaccg      660

tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag      720

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      780

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag      840

acaaagccgc gggaggagca gtacgccagc acgtaccgtg tggtcagcgt cctcaccgtc      900

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc      960

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1020

tacaccctgc ccccatcccg ggaggagatg accaagaacc aggtcagcct gacctgcctg     1080

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1140

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1200

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1260

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaa        1317


<210>  412
<211>  327
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  412
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggaatcga cctcaatagc tactacatga cctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggattcatt gatgctggtg gtgacgcata ctacgcgagc      180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatcacc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gagatcttga cttgtggggc      300

cagggcaccc tggtcaccgt ctcgagc                                          327


<210>  413
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  413
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggaatcga cctcaat                                           87


<210>  414
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  414
agctactaca tgacc                                                        15


<210>  415
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  415
tgggtccgcc aggctccagg gaaggggctg gaatggatcg ga                          42


<210>  416
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  416
ttcattgatg ctggtggtga cgcatactac gcgagctggg cgaaaggc                    48


<210>  417
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  417
cgattcacca tctccaaaac ctcgaccacg gtggatctga aaatcaccag tccgacaacc       60

gaggacacgg ccacctattt ctgtgccaga                                        90


<210>  418
<211>  12
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  418
gatcttgact tg                                                           12


<210>  419
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  419
tggggccagg gcaccctggt caccgtctcg agc                                    33


<210>  420
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  420
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  421
<211>  216
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  421

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Glu Ser Val Tyr Gly Asn 
            20                  25                  30          


Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Ala Ser Lys Leu Glu Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Gln 
65                  70                  75                  80  


Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Asp Ile Ser Glu 
                85                  90                  95      


Gly Val Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  422
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  422

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Glu Ser Val Tyr Gly Asn 
            20                  25                  30          


Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Ala Ser Lys Leu Glu Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Gln 
65                  70                  75                  80  


Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Asp Ile Ser Glu 
                85                  90                  95      


Gly Val Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110 


<210>  423
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  423

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys 
            20              


<210>  424
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  424

Gln Ser Ser Glu Ser Val Tyr Gly Asn Tyr Leu Ala 
1               5                   10          


<210>  425
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  425

Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  426
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  426

Glu Ala Ser Lys Leu Glu Ser 
1               5           


<210>  427
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  427

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  428
<211>  10
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  428

Ala Gly Gly Asp Ile Ser Glu Gly Val Ala 
1               5                   10  


<210>  429
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  429

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  430
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  430

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  431
<211>  648
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  431
gccgccgtgc tgacccagac tccatctccc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc agtccagtga gagtgtttac ggtaactact tagcctggtt tcagcagaaa      120

ccagggcagc ctcccaagct cctgatctac gaagcatcca aactggaatc tggggtccca      180

tcgcggttca gcggcagtgg atctgggaca cagttcactc tcaccatcag cgacttgcag      240

tgtgacgatg ctgccactta ctactgtgca ggcggtgata ttagtgaagg tgttgctttc      300

ggcggaggga ccgaggtggt ggtcaaacgt acggtagcgg ccccatctgt cttcatcttc      360

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      420

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      480

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      540

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      600

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                   648


<210>  432
<211>  330
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  432
gccgccgtgc tgacccagac tccatctccc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc agtccagtga gagtgtttac ggtaactact tagcctggtt tcagcagaaa      120

ccagggcagc ctcccaagct cctgatctac gaagcatcca aactggaatc tggggtccca      180

tcgcggttca gcggcagtgg atctgggaca cagttcactc tcaccatcag cgacttgcag      240

tgtgacgatg ctgccactta ctactgtgca ggcggtgata ttagtgaagg tgttgctttc      300

ggcggaggga ccgaggtggt ggtcaaacgt                                       330


<210>  433
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  433
gccgccgtgc tgacccagac tccatctccc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgc                                                               69


<210>  434
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  434
cagtccagtg agagtgttta cggtaactac ttagcc                                 36


<210>  435
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  435
tggtttcagc agaaaccagg gcagcctccc aagctcctga tctac                       45


<210>  436
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  436
gaagcatcca aactggaatc t                                                 21


<210>  437
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  437
ggggtcccat cgcggttcag cggcagtgga tctgggacac agttcactct caccatcagc       60

gacttgcagt gtgacgatgc tgccacttac tactgt                                 96


<210>  438
<211>  30
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  438
gcaggcggtg atattagtga aggtgttgct                                        30


<210>  439
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  439
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  440
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  440
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  441
<211>  439
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  441

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Tyr Tyr 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Phe Ile Asp Thr Asp Gly Ser Ala Tyr Tyr Ala Thr Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Leu 
                85                  90                  95      


Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
            100                 105                 110         


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
        115                 120                 125             


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
    130                 135                 140                 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
145                 150                 155                 160 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
                165                 170                 175     


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
            180                 185                 190         


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
        195                 200                 205             


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    210                 215                 220                 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
225                 230                 235                 240 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                245                 250                 255     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            260                 265                 270         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        275                 280                 285             


Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    290                 295                 300                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
305                 310                 315                 320 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                325                 330                 335     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            340                 345                 350         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        355                 360                 365             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    370                 375                 380                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
385                 390                 395                 400 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                405                 410                 415     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            420                 425                 430         


Leu Ser Leu Ser Pro Gly Lys 
        435                 


<210>  442
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  442

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Tyr Tyr 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Phe Ile Asp Thr Asp Gly Ser Ala Tyr Tyr Ala Thr Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Leu 
                85                  90                  95      


Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 


<210>  443
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  443

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser 
            20                  25                  


<210>  444
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  444

Ser Tyr Tyr Met Ser 
1               5   


<210>  445
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  445

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  446
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  446

Phe Ile Asp Thr Asp Gly Ser Ala Tyr Tyr Ala Thr Trp Ala Lys Gly 
1               5                   10                  15      


<210>  447
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  447

Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
1               5                   10                  15      


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  448
<211>  4
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  448

Asp Leu Asp Leu 
1               


<210>  449
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  449

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  450
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  450

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  451
<211>  1317
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  451
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggaatcga cctcagtagc tactacatga gctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggattcatt gatactgatg gtagcgcata ctacgcgacc      180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatcacc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gagatcttga cttgtggggc      300

ccgggcaccc tcgtcaccgt ctcgagcgcc tccaccaagg gcccatcggt cttccccctg      360

gcaccctcct ccaagagcac ctctgggggc acagcggccc tgggctgcct ggtcaaggac      420

tacttccccg aaccggtgac ggtgtcgtgg aactcaggcg ccctgaccag cggcgtgcac      480

accttcccgg ctgtcctaca gtcctcagga ctctactccc tcagcagcgt ggtgaccgtg      540

ccctccagca gcttgggcac ccagacctac atctgcaacg tgaatcacaa gcccagcaac      600

accaaggtgg acaagaaagt tgagcccaaa tcttgtgaca aaactcacac atgcccaccg      660

tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag      720

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      780

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag      840

acaaagccgc gggaggagca gtacgccagc acgtaccgtg tggtcagcgt cctcaccgtc      900

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc      960

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1020

tacaccctgc ccccatcccg ggaggagatg accaagaacc aggtcagcct gacctgcctg     1080

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1140

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1200

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1260

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaa        1317


<210>  452
<211>  327
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  452
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggaatcga cctcagtagc tactacatga gctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggattcatt gatactgatg gtagcgcata ctacgcgacc      180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatcacc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gagatcttga cttgtggggc      300

ccgggcaccc tcgtcaccgt ctcgagc                                          327


<210>  453
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  453
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggaatcga cctcagt                                           87


<210>  454
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  454
agctactaca tgagc                                                        15


<210>  455
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  455
tgggtccgcc aggctccagg gaaggggctg gaatggatcg ga                          42


<210>  456
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  456
ttcattgata ctgatggtag cgcatactac gcgacctggg cgaaaggc                    48


<210>  457
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  457
cgattcacca tctccaaaac ctcgaccacg gtggatctga aaatcaccag tccgacaacc       60

gaggacacgg ccacctattt ctgtgccaga                                        90


<210>  458
<211>  12
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  458
gatcttgact tg                                                           12


<210>  459
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  459
tggggcccgg gcaccctcgt caccgtctcg agc                                    33


<210>  460
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  460
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  461
<211>  216
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  461

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Ser Ile Ser Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn 
            20                  25                  30          


Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Phe Leu 
        35                  40                  45              


Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val Gln 
65                  70                  75                  80  


Cys Asp Asp Ala Gly Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Ser Glu 
                85                  90                  95      


Gly Val Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  462
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  462

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Ser Ile Ser Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn 
            20                  25                  30          


Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Phe Leu 
        35                  40                  45              


Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val Gln 
65                  70                  75                  80  


Cys Asp Asp Ala Gly Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Ser Glu 
                85                  90                  95      


Gly Val Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110 


<210>  463
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  463

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Ser Ile Ser Cys 
            20              


<210>  464
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  464

Gln Ser Ser Glu Ser Val Tyr Ser Asn Tyr Leu Ala 
1               5                   10          


<210>  465
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  465

Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Phe Leu Ile Tyr 
1               5                   10                  15  


<210>  466
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  466

Glu Ala Ser Lys Leu Ala Ser 
1               5           


<210>  467
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  467

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Val Gln Cys Asp Asp Ala Gly Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  468
<211>  10
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  468

Ala Gly Gly Tyr Ser Ser Glu Gly Val Ala 
1               5                   10  


<210>  469
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  469

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  470
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  470

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  471
<211>  648
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  471
gccgccgtgc tgacccagac tccatctccc gtgtctgcag ctgtgggagg cacagtcagc       60

atcagttgcc agtccagtga gagtgtttat agtaactact tagcctggtt tcagcagaaa      120

ccagggcagc ctcctaagtt cttgatctac gaagcatcca aactggcatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca cagttcactc tcaccatcag cgacgtgcag      240

tgtgacgatg ctggcactta ctactgtgca ggcggctata gtagtgaagg tgttgctttc      300

ggcggaggga ccgaggtggt ggtcaaacgt acggtagcgg ccccatctgt cttcatcttc      360

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      420

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      480

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      540

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      600

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                   648


<210>  472
<211>  330
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  472
gccgccgtgc tgacccagac tccatctccc gtgtctgcag ctgtgggagg cacagtcagc       60

atcagttgcc agtccagtga gagtgtttat agtaactact tagcctggtt tcagcagaaa      120

ccagggcagc ctcctaagtt cttgatctac gaagcatcca aactggcatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca cagttcactc tcaccatcag cgacgtgcag      240

tgtgacgatg ctggcactta ctactgtgca ggcggctata gtagtgaagg tgttgctttc      300

ggcggaggga ccgaggtggt ggtcaaacgt                                       330


<210>  473
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  473
gccgccgtgc tgacccagac tccatctccc gtgtctgcag ctgtgggagg cacagtcagc       60

atcagttgc                                                               69


<210>  474
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  474
cagtccagtg agagtgttta tagtaactac ttagcc                                 36


<210>  475
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  475
tggtttcagc agaaaccagg gcagcctcct aagttcttga tctac                       45


<210>  476
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  476
gaagcatcca aactggcatc t                                                 21


<210>  477
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  477
ggggtcccat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcagc       60

gacgtgcagt gtgacgatgc tggcacttac tactgt                                 96


<210>  478
<211>  30
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  478
gcaggcggct atagtagtga aggtgttgct                                        30


<210>  479
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  479
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  480
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  480
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318

<210>  481

<400>  481

000

<210>  482

<400>  482

000

<210>  483

<400>  483

000

<210>  484

<400>  484

000

<210>  485

<400>  485

000

<210>  486

<400>  486

000

<210>  487

<400>  487

000

<210>  488

<400>  488

000

<210>  489

<400>  489

000

<210>  490

<400>  490

000

<210>  491

<400>  491

000

<210>  492

<400>  492

000

<210>  493

<400>  493

000

<210>  494

<400>  494

000

<210>  495

<400>  495

000

<210>  496

<400>  496

000

<210>  497

<400>  497

000

<210>  498

<400>  498

000

<210>  499

<400>  499

000

<210>  500

<400>  500

000

<210>  501

<400>  501

000

<210>  502

<400>  502

000

<210>  503

<400>  503

000

<210>  504

<400>  504

000

<210>  505

<400>  505

000

<210>  506

<400>  506

000

<210>  507

<400>  507

000

<210>  508

<400>  508

000

<210>  509

<400>  509

000

<210>  510

<400>  510

000

<210>  511

<400>  511

000

<210>  512

<400>  512

000

<210>  513

<400>  513

000

<210>  514

<400>  514

000

<210>  515

<400>  515

000

<210>  516

<400>  516

000

<210>  517

<400>  517

000

<210>  518

<400>  518

000

<210>  519

<400>  519

000

<210>  520

<400>  520

000

<210>  521

<400>  521

000

<210>  522

<400>  522

000

<210>  523

<400>  523

000

<210>  524

<400>  524

000

<210>  525

<400>  525

000

<210>  526

<400>  526

000

<210>  527

<400>  527

000

<210>  528

<400>  528

000

<210>  529

<400>  529

000

<210>  530

<400>  530

000

<210>  531

<400>  531

000

<210>  532

<400>  532

000

<210>  533

<400>  533

000

<210>  534

<400>  534

000

<210>  535

<400>  535

000

<210>  536

<400>  536

000

<210>  537

<400>  537

000

<210>  538

<400>  538

000

<210>  539

<400>  539

000

<210>  540

<400>  540

000

<210>  541

<400>  541

000

<210>  542

<400>  542

000

<210>  543

<400>  543

000

<210>  544

<400>  544

000

<210>  545

<400>  545

000

<210>  546

<400>  546

000

<210>  547

<400>  547

000

<210>  548

<400>  548

000

<210>  549

<400>  549

000

<210>  550

<400>  550

000

<210>  551

<400>  551

000

<210>  552

<400>  552

000

<210>  553

<400>  553

000

<210>  554

<400>  554

000

<210>  555

<400>  555

000

<210>  556

<400>  556

000

<210>  557

<400>  557

000

<210>  558

<400>  558

000

<210>  559

<400>  559

000

<210>  560

<400>  560

000

<210>  561

<400>  561

000

<210>  562

<400>  562

000

<210>  563

<400>  563

000

<210>  564

<400>  564

000

<210>  565

<400>  565

000

<210>  566

<400>  566

000

<210>  567

<400>  567

000

<210>  568

<400>  568

000

<210>  569

<400>  569

000

<210>  570

<400>  570

000

<210>  571

<400>  571

000

<210>  572

<400>  572

000

<210>  573

<400>  573

000

<210>  574

<400>  574

000

<210>  575

<400>  575

000

<210>  576

<400>  576

000

<210>  577

<400>  577

000

<210>  578

<400>  578

000

<210>  579

<400>  579

000

<210>  580

<400>  580

000

<210>  581

<400>  581

000

<210>  582

<400>  582

000

<210>  583

<400>  583

000

<210>  584

<400>  584

000

<210>  585

<400>  585

000

<210>  586

<400>  586

000

<210>  587

<400>  587

000

<210>  588

<400>  588

000

<210>  589

<400>  589

000

<210>  590

<400>  590

000

<210>  591

<400>  591

000

<210>  592

<400>  592

000

<210>  593

<400>  593

000

<210>  594

<400>  594

000

<210>  595

<400>  595

000

<210>  596

<400>  596

000

<210>  597

<400>  597

000

<210>  598

<400>  598

000

<210>  599

<400>  599

000

<210>  600

<400>  600

000

<210>  601

<400>  601

000

<210>  602

<400>  602

000

<210>  603

<400>  603

000

<210>  604

<400>  604

000

<210>  605

<400>  605

000

<210>  606

<400>  606

000

<210>  607

<400>  607

000

<210>  608

<400>  608

000

<210>  609

<400>  609

000

<210>  610

<400>  610

000

<210>  611

<400>  611

000

<210>  612

<400>  612

000

<210>  613

<400>  613

000

<210>  614

<400>  614

000

<210>  615

<400>  615

000

<210>  616

<400>  616

000

<210>  617

<400>  617

000

<210>  618

<400>  618

000

<210>  619

<400>  619

000

<210>  620

<400>  620

000

<210>  621

<400>  621

000

<210>  622

<400>  622

000

<210>  623

<400>  623

000

<210>  624

<400>  624

000

<210>  625

<400>  625

000

<210>  626

<400>  626

000

<210>  627

<400>  627

000

<210>  628

<400>  628

000

<210>  629

<400>  629

000

<210>  630

<400>  630

000

<210>  631

<400>  631

000

<210>  632

<400>  632

000

<210>  633

<400>  633

000

<210>  634

<400>  634

000

<210>  635

<400>  635

000

<210>  636

<400>  636

000

<210>  637

<400>  637

000

<210>  638

<400>  638

000

<210>  639

<400>  639

000

<210>  640

<400>  640

000

<210>  641

<400>  641

000

<210>  642

<400>  642

000

<210>  643

<400>  643

000

<210>  644

<400>  644

000

<210>  645

<400>  645

000

<210>  646

<400>  646

000

<210>  647

<400>  647

000

<210>  648

<400>  648

000

<210>  649

<400>  649

000

<210>  650

<400>  650

000

<210>  651

<400>  651

000

<210>  652

<400>  652

000

<210>  653

<400>  653

000

<210>  654

<400>  654

000

<210>  655

<400>  655

000

<210>  656

<400>  656

000

<210>  657

<400>  657

000

<210>  658

<400>  658

000

<210>  659

<400>  659

000

<210>  660

<400>  660

000

<210>  661

<400>  661

000

<210>  662

<400>  662

000

<210>  663

<400>  663

000

<210>  664

<400>  664

000

<210>  665

<400>  665

000

<210>  666

<400>  666

000

<210>  667

<400>  667

000

<210>  668

<400>  668

000

<210>  669

<400>  669

000

<210>  670

<400>  670

000

<210>  671

<400>  671

000

<210>  672

<400>  672

000

<210>  673

<400>  673

000

<210>  674

<400>  674

000

<210>  675

<400>  675

000

<210>  676

<400>  676

000

<210>  677

<400>  677

000

<210>  678

<400>  678

000

<210>  679

<400>  679

000

<210>  680

<400>  680

000

<210>  681

<400>  681

000

<210>  682

<400>  682

000

<210>  683

<400>  683

000

<210>  684

<400>  684

000

<210>  685

<400>  685

000

<210>  686

<400>  686

000

<210>  687

<400>  687

000

<210>  688

<400>  688

000

<210>  689

<400>  689

000

<210>  690

<400>  690

000

<210>  691

<400>  691

000

<210>  692

<400>  692

000

<210>  693

<400>  693

000

<210>  694

<400>  694

000

<210>  695

<400>  695

000

<210>  696

<400>  696

000

<210>  697

<400>  697

000

<210>  698

<400>  698

000

<210>  699

<400>  699

000

<210>  700

<400>  700

000

<210>  701

<400>  701

000

<210>  702

<400>  702

000

<210>  703

<400>  703

000

<210>  704

<400>  704

000

<210>  705

<400>  705

000

<210>  706

<400>  706

000

<210>  707

<400>  707

000

<210>  708

<400>  708

000

<210>  709

<400>  709

000

<210>  710

<400>  710

000

<210>  711

<400>  711

000

<210>  712

<400>  712

000

<210>  713

<400>  713

000

<210>  714

<400>  714

000

<210>  715

<400>  715

000

<210>  716

<400>  716

000

<210>  717

<400>  717

000

<210>  718

<400>  718

000

<210>  719

<400>  719

000

<210>  720

<400>  720

000

<210>  721

<400>  721

000

<210>  722

<400>  722

000

<210>  723

<400>  723

000

<210>  724

<400>  724

000

<210>  725

<400>  725

000

<210>  726

<400>  726

000

<210>  727

<400>  727

000

<210>  728

<400>  728

000

<210>  729

<400>  729

000

<210>  730

<400>  730

000

<210>  731

<400>  731

000

<210>  732

<400>  732

000

<210>  733

<400>  733

000

<210>  734

<400>  734

000

<210>  735

<400>  735

000

<210>  736

<400>  736

000

<210>  737

<400>  737

000

<210>  738

<400>  738

000

<210>  739

<400>  739

000

<210>  740

<400>  740

000

<210>  741

<400>  741

000

<210>  742

<400>  742

000

<210>  743

<400>  743

000

<210>  744

<400>  744

000

<210>  745

<400>  745

000

<210>  746

<400>  746

000

<210>  747

<400>  747

000

<210>  748

<400>  748

000

<210>  749

<400>  749

000

<210>  750

<400>  750

000

<210>  751

<400>  751

000

<210>  752

<400>  752

000

<210>  753

<400>  753

000

<210>  754

<400>  754

000

<210>  755

<400>  755

000

<210>  756

<400>  756

000

<210>  757

<400>  757

000

<210>  758

<400>  758

000

<210>  759

<400>  759

000

<210>  760

<400>  760

000

<210>  761

<400>  761

000

<210>  762

<400>  762

000

<210>  763

<400>  763

000

<210>  764

<400>  764

000

<210>  765

<400>  765

000

<210>  766

<400>  766

000

<210>  767

<400>  767

000

<210>  768

<400>  768

000

<210>  769

<400>  769

000

<210>  770

<400>  770

000

<210>  771

<400>  771

000

<210>  772

<400>  772

000

<210>  773

<400>  773

000

<210>  774

<400>  774

000

<210>  775

<400>  775

000

<210>  776

<400>  776

000

<210>  777

<400>  777

000

<210>  778

<400>  778

000

<210>  779

<400>  779

000

<210>  780

<400>  780

000

<210>  781

<400>  781

000

<210>  782

<400>  782

000

<210>  783

<400>  783

000

<210>  784

<400>  784

000

<210>  785

<400>  785

000

<210>  786

<400>  786

000

<210>  787

<400>  787

000

<210>  788

<400>  788

000

<210>  789

<400>  789

000

<210>  790

<400>  790

000

<210>  791

<400>  791

000

<210>  792

<400>  792

000

<210>  793

<400>  793

000

<210>  794

<400>  794

000

<210>  795

<400>  795

000

<210>  796

<400>  796

000

<210>  797

<400>  797

000

<210>  798

<400>  798

000

<210>  799

<400>  799

000

<210>  800

<400>  800

000

<210>  801

<400>  801

000

<210>  802

<400>  802

000

<210>  803

<400>  803

000

<210>  804

<400>  804

000

<210>  805

<400>  805

000

<210>  806

<400>  806

000

<210>  807

<400>  807

000

<210>  808

<400>  808

000

<210>  809

<400>  809

000

<210>  810

<400>  810

000

<210>  811

<400>  811

000

<210>  812

<400>  812

000

<210>  813

<400>  813

000

<210>  814

<400>  814

000

<210>  815

<400>  815

000

<210>  816

<400>  816

000

<210>  817

<400>  817

000

<210>  818

<400>  818

000

<210>  819

<400>  819

000

<210>  820

<400>  820

000

<210>  821

<400>  821

000

<210>  822

<400>  822

000

<210>  823

<400>  823

000

<210>  824

<400>  824

000

<210>  825

<400>  825

000

<210>  826

<400>  826

000

<210>  827

<400>  827

000

<210>  828

<400>  828

000

<210>  829

<400>  829

000

<210>  830

<400>  830

000

<210>  831

<400>  831

000

<210>  832

<400>  832

000

<210>  833

<400>  833

000

<210>  834

<400>  834

000

<210>  835

<400>  835

000

<210>  836

<400>  836

000

<210>  837

<400>  837

000

<210>  838

<400>  838

000

<210>  839

<400>  839

000

<210>  840

<400>  840

000

<210>  841
<211>  439
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  841

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Tyr Tyr 
            20                  25                  30          


Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
        35                  40                  45              


Phe Ile Asp Ala Gly Gly Ser Ala Tyr Tyr Ala Thr Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Ala Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Leu 
                85                  90                  95      


Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
            100                 105                 110         


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
        115                 120                 125             


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
    130                 135                 140                 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
145                 150                 155                 160 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
                165                 170                 175     


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
            180                 185                 190         


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
        195                 200                 205             


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    210                 215                 220                 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
225                 230                 235                 240 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                245                 250                 255     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            260                 265                 270         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        275                 280                 285             


Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    290                 295                 300                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
305                 310                 315                 320 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                325                 330                 335     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            340                 345                 350         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        355                 360                 365             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    370                 375                 380                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
385                 390                 395                 400 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                405                 410                 415     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            420                 425                 430         


Leu Ser Leu Ser Pro Gly Lys 
        435                 


<210>  842
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  842

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Tyr Tyr 
            20                  25                  30          


Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
        35                  40                  45              


Phe Ile Asp Ala Gly Gly Ser Ala Tyr Tyr Ala Thr Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Ala Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Leu 
                85                  90                  95      


Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 


<210>  843
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  843

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser 
            20                  25                  


<210>  844
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  844

Ser Tyr Tyr Met Thr 
1               5   


<210>  845
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  845

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
1               5                   10                  


<210>  846
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  846

Phe Ile Asp Ala Gly Gly Ser Ala Tyr Tyr Ala Thr Trp Ala Lys Gly 
1               5                   10                  15      


<210>  847
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  847

Arg Phe Thr Ile Ser Lys Ala Ser Thr Thr Val Asp Leu Lys Ile Thr 
1               5                   10                  15      


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  848
<211>  4
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  848

Asp Leu Asp Leu 
1               


<210>  849
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  849

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  850
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  850

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  851
<211>  1317
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  851
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggaatcga cctcagtagc tactacatga cctgggtccg ccaggctcca      120

gggaaggggc tggaatgggt cggattcatt gatgctggtg gtagcgcata ctacgcgacc      180

tgggcaaaag gccgattcac catctccaaa gcctcgacca cggtggatct gaaaatcacc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gagatcttga cttgtggggc      300

ccgggcaccc tggtcaccgt ctcgagcgcc tccaccaagg gcccatcggt cttccccctg      360

gcaccctcct ccaagagcac ctctgggggc acagcggccc tgggctgcct ggtcaaggac      420

tacttccccg aaccggtgac ggtgtcgtgg aactcaggcg ccctgaccag cggcgtgcac      480

accttcccgg ctgtcctaca gtcctcagga ctctactccc tcagcagcgt ggtgaccgtg      540

ccctccagca gcttgggcac ccagacctac atctgcaacg tgaatcacaa gcccagcaac      600

accaaggtgg acaagaaagt tgagcccaaa tcttgtgaca aaactcacac atgcccaccg      660

tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag      720

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      780

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag      840

acaaagccgc gggaggagca gtacgccagc acgtaccgtg tggtcagcgt cctcaccgtc      900

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc      960

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1020

tacaccctgc ccccatcccg ggaggagatg accaagaacc aggtcagcct gacctgcctg     1080

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1140

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1200

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1260

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaa        1317


<210>  852
<211>  327
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  852
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggaatcga cctcagtagc tactacatga cctgggtccg ccaggctcca      120

gggaaggggc tggaatgggt cggattcatt gatgctggtg gtagcgcata ctacgcgacc      180

tgggcaaaag gccgattcac catctccaaa gcctcgacca cggtggatct gaaaatcacc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gagatcttga cttgtggggc      300

ccgggcaccc tggtcaccgt ctcgagc                                          327


<210>  853
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  853
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggaatcga cctcagt                                           87


<210>  854
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  854
agctactaca tgacc                                                        15


<210>  855
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  855
tgggtccgcc aggctccagg gaaggggctg gaatgggtcg ga                          42


<210>  856
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  856
ttcattgatg ctggtggtag cgcatactac gcgacctggg caaaaggc                    48


<210>  857
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  857
cgattcacca tctccaaagc ctcgaccacg gtggatctga aaatcaccag tccgacaacc       60

gaggacacgg ccacctattt ctgtgccaga                                        90


<210>  858
<211>  12
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  858
gatcttgact tg                                                           12


<210>  859
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  859
tggggcccgg gcaccctggt caccgtctcg agc                                    33


<210>  860
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  860
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  861
<211>  216
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  861

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Ser Ile Ser Cys Lys Ser Ser Glu Ser Val Tyr Gly Asp 
            20                  25                  30          


Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Gln Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Gln 
65                  70                  75                  80  


Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Val Ser Ala 
                85                  90                  95      


Gly Val Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  862
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  862

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Ser Ile Ser Cys Lys Ser Ser Glu Ser Val Tyr Gly Asp 
            20                  25                  30          


Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Gln Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Gln 
65                  70                  75                  80  


Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Val Ser Ala 
                85                  90                  95      


Gly Val Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110 


<210>  863
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  863

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Ser Ile Ser Cys 
            20              


<210>  864
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  864

Lys Ser Ser Glu Ser Val Tyr Gly Asp Tyr Leu Ala 
1               5                   10          


<210>  865
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  865

Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Gln Leu Ile Tyr 
1               5                   10                  15  


<210>  866
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  866

Asp Ala Ser Thr Leu Ala Ser 
1               5           


<210>  867
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  867

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Gly Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  868
<211>  10
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  868

Ala Gly Gly Tyr Val Ser Ala Gly Val Ala 
1               5                   10  


<210>  869
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  869

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  870
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  870

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  871
<211>  648
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  871
gccgccgtgc tgacccagac tccatctccc gtgtctgcag ctgtgggagg cacagtcagc       60

atcagttgca agtccagtga gagcgtttat ggtgactact tagcctggtt tcagcagaaa      120

ccagggcagc ctcccaagca actgatctat gatgcatcca ctctggcatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca cagttcactc tcaccatcag cggcgtgcag      240

tgtgacgatg ctgccactta ctactgtgca ggcggttatg ttagtgcagg tgttgctttc      300

ggcggaggga ccgaggtggt ggtcaaacgt acggtagcgg ccccatctgt cttcatcttc      360

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      420

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      480

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      540

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      600

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                   648


<210>  872
<211>  330
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  872
gccgccgtgc tgacccagac tccatctccc gtgtctgcag ctgtgggagg cacagtcagc       60

atcagttgca agtccagtga gagcgtttat ggtgactact tagcctggtt tcagcagaaa      120

ccagggcagc ctcccaagca actgatctat gatgcatcca ctctggcatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca cagttcactc tcaccatcag cggcgtgcag      240

tgtgacgatg ctgccactta ctactgtgca ggcggttatg ttagtgcagg tgttgctttc      300

ggcggaggga ccgaggtggt ggtcaaacgt                                       330


<210>  873
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  873
gccgccgtgc tgacccagac tccatctccc gtgtctgcag ctgtgggagg cacagtcagc       60

atcagttgc                                                               69


<210>  874
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  874
aagtccagtg agagcgttta tggtgactac ttagcc                                 36


<210>  875
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  875
tggtttcagc agaaaccagg gcagcctccc aagcaactga tctat                       45


<210>  876
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  876
gatgcatcca ctctggcatc t                                                 21


<210>  877
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  877
ggggtcccat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcagc       60

ggcgtgcagt gtgacgatgc tgccacttac tactgt                                 96


<210>  878
<211>  30
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  878
gcaggcggtt atgttagtgc aggtgttgct                                        30


<210>  879
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  879
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  880
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  880
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  881
<211>  442
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  881

Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Asp Phe Ser Ser Asn 
            20                  25                  30          


Ala Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Tyr Asn Ala Asp Gly Lys Asn Tyr Tyr Ala Ile Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Thr Ser Ser Thr Thr Val Thr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Asp Phe Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
        115                 120                 125             


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
                165                 170                 175     


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
            180                 185                 190         


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
        195                 200                 205             


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440         


<210>  882
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  882

Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Asp Phe Ser Ser Asn 
            20                  25                  30          


Ala Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Tyr Asn Ala Asp Gly Lys Asn Tyr Tyr Ala Ile Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Thr Ser Ser Thr Thr Val Thr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Asp Phe Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  883
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  883

Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Asp Phe Ser 
            20                  25                  30  


<210>  884
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  884

Ser Asn Ala Met Cys 
1               5   


<210>  885
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  885

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  886
<211>  17
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  886

Ser Ile Tyr Asn Ala Asp Gly Lys Asn Tyr Tyr Ala Ile Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  887
<211>  31
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  887

Arg Phe Thr Ile Ser Arg Thr Ser Ser Thr Thr Val Thr Leu Gln Met 
1               5                   10                  15      


Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30      


<210>  888
<211>  4
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  888

Asp Phe Asp Leu 
1               


<210>  889
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  889

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  890
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  890

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  891
<211>  1326
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  891
caggagcagc tggtggagtc cgggggaggc ctggtccagc ctgagggatc cctgacactc       60

acctgcacag cctctggatt cgacttcagt agcaatgcaa tgtgctgggt ccgccaggct      120

ccagggaagg gcctggagtg gatcggatcc atttataatg ctgatggtaa gaattattac      180

gcgatttggg cgaaaggccg attcaccatc tccagaacct cgtcgaccac ggtgactctg      240

caaatgacca gtctgacagc cgcggacacg gccacctatt tctgtgcgag agactttgac      300

ttgtggggcc agggcaccct cgtcaccgtc tcgagcgcct ccaccaaggg cccatcggtc      360

ttccccctgg caccctcctc caagagcacc tctgggggca cagcggccct gggctgcctg      420

gtcaaggact acttccccga accggtgacg gtgtcgtgga actcaggcgc cctgaccagc      480

ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac tctactccct cagcagcgtg      540

gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag      600

cccagcaaca ccaaggtgga cgcgagagtt gagcccaaat cttgtgacaa aactcacaca      660

tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca      720

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      780

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat      840

aatgccaaga caaagccgcg ggaggagcag tacgccagca cgtaccgtgt ggtcagcgtc      900

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac      960

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1020

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg     1080

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1140

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1200

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1260

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1320

ggtaaa                                                                1326


<210>  892
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  892
caggagcagc tggtggagtc cgggggaggc ctggtccagc ctgagggatc cctgacactc       60

acctgcacag cctctggatt cgacttcagt agcaatgcaa tgtgctgggt ccgccaggct      120

ccagggaagg gcctggagtg gatcggatcc atttataatg ctgatggtaa gaattattac      180

gcgatttggg cgaaaggccg attcaccatc tccagaacct cgtcgaccac ggtgactctg      240

caaatgacca gtctgacagc cgcggacacg gccacctatt tctgtgcgag agactttgac      300

ttgtggggcc agggcaccct cgtcaccgtc tcgagc                                336


<210>  893
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  893
caggagcagc tggtggagtc cgggggaggc ctggtccagc ctgagggatc cctgacactc       60

acctgcacag cctctggatt cgacttcagt                                        90


<210>  894
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  894
agcaatgcaa tgtgc                                                        15


<210>  895
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  895
tgggtccgcc aggctccagg gaagggcctg gagtggatcg ga                          42


<210>  896
<211>  51
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  896
tccatttata atgctgatgg taagaattat tacgcgattt gggcgaaagg c                51


<210>  897
<211>  93
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  897
cgattcacca tctccagaac ctcgtcgacc acggtgactc tgcaaatgac cagtctgaca       60

gccgcggaca cggccaccta tttctgtgcg aga                                    93


<210>  898
<211>  12
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  898
gactttgact tg                                                           12


<210>  899
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  899
tggggccagg gcaccctcgt caccgtctcg agc                                    33


<210>  900
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  900
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  901
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  901

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Tyr Asp Asn 
            20                  25                  30          


Asp Trp Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Leu Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp Glu 
                85                  90                  95      


Asp Gly Asp Thr His Val Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  902
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  902

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Tyr Asp Asn 
            20                  25                  30          


Asp Trp Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Leu Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp Glu 
                85                  90                  95      


Asp Gly Asp Thr His Val Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg 
    


<210>  903
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  903

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys 
            20              


<210>  904
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  904

Gln Ser Ser Gln Ser Val Tyr Asp Asn Asp Trp Leu Ala 
1               5                   10              


<210>  905
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  905

Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  906
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  906

Leu Thr Ser Thr Leu Ala Ser 
1               5           


<210>  907
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  907

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Gly Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  908
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  908

Leu Gly Gly Tyr Asp Glu Asp Gly Asp Thr His Val 
1               5                   10          


<210>  909
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  909

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  910
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  910

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  911
<211>  657
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  911
gcagccgtgc tgacccagac accatcgccc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc agtccagtca gagtgtttat gataacgact ggttagcctg gttccagcag      120

aaaccagggc agcctcccaa gctcctgatc tatctgacat ccactctggc atctggagtc      180

ccatcgcggt tcagcggcag tggatctggg acacagttca ctctcaccat cagtggtgtg      240

cagtgtgacg atgctgccac ttactactgt ctaggcggct atgatgaaga tggtgatacg      300

catgttttcg gcggagggac cgaggtggtg gtcaaacgta cggtagcggc cccatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  912
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  912
gcagccgtgc tgacccagac accatcgccc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc agtccagtca gagtgtttat gataacgact ggttagcctg gttccagcag      120

aaaccagggc agcctcccaa gctcctgatc tatctgacat ccactctggc atctggagtc      180

ccatcgcggt tcagcggcag tggatctggg acacagttca ctctcaccat cagtggtgtg      240

cagtgtgacg atgctgccac ttactactgt ctaggcggct atgatgaaga tggtgatacg      300

catgttttcg gcggagggac cgaggtggtg gtcaaacgt                             339


<210>  913
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  913
gcagccgtgc tgacccagac accatcgccc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgc                                                               69


<210>  914
<211>  39
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  914
cagtccagtc agagtgttta tgataacgac tggttagcc                              39


<210>  915
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  915
tggttccagc agaaaccagg gcagcctccc aagctcctga tctat                       45


<210>  916
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  916
ctgacatcca ctctggcatc t                                                 21


<210>  917
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  917
ggagtcccat cgcggttcag cggcagtgga tctgggacac agttcactct caccatcagt       60

ggtgtgcagt gtgacgatgc tgccacttac tactgt                                 96


<210>  918
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  918
ctaggcggct atgatgaaga tggtgatacg catgtt                                 36


<210>  919
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  919
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  920
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  920
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  921
<211>  447
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  921

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Asn Tyr Ala 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Met Gly Val Asn Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Thr Arg Glu Ile 
                85                  90                  95      


Arg Asp Asp Gly Asp Ser Ser Asp Lys Leu Trp Gly Pro Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Ala Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  922
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  922

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Asn Tyr Ala 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Met Gly Val Asn Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Thr Arg Glu Ile 
                85                  90                  95      


Arg Asp Asp Gly Asp Ser Ser Asp Lys Leu Trp Gly Pro Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  923
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  923

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn 
            20                  25                  


<210>  924
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  924

Asn Tyr Ala Met Ser 
1               5   


<210>  925
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  925

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  926
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  926

Ile Met Gly Val Asn Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  927
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  927

Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
1               5                   10                  15      


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Thr Arg 
            20                  25                  30  


<210>  928
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  928

Glu Ile Arg Asp Asp Gly Asp Ser Ser Asp Lys Leu 
1               5                   10          


<210>  929
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  929

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  930
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  930

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  931
<211>  1341
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  931
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcaataac tatgcaatga gctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggaatcatg ggtgttaatg atatcacata ctacgcgagc      180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatgacc      240

agtctgacaa ccgaggacac ggccacctat ttctgtacta gagagatccg tgatgatggt      300

gatagttctg ataagttgtg gggcccgggc accctcgtca ccgtctcgag cgcctccacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacgcga gagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacgc cagcacgtac      900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa a                                               1341


<210>  932
<211>  351
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  932
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcaataac tatgcaatga gctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggaatcatg ggtgttaatg atatcacata ctacgcgagc      180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatgacc      240

agtctgacaa ccgaggacac ggccacctat ttctgtacta gagagatccg tgatgatggt      300

gatagttctg ataagttgtg gggcccgggc accctcgtca ccgtctcgag c               351


<210>  933
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  933
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctggattctc cctcaat                                           87


<210>  934
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  934
aactatgcaa tgagc                                                        15


<210>  935
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  935
tgggtccgcc aggctccagg gaaggggctg gaatggatcg ga                          42


<210>  936
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  936
atcatgggtg ttaatgatat cacatactac gcgagctggg cgaaaggc                    48


<210>  937
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  937
cgattcacca tctccaaaac ctcgaccacg gtggatctga aaatgaccag tctgacaacc       60

gaggacacgg ccacctattt ctgtactaga                                        90


<210>  938
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  938
gagatccgtg atgatggtga tagttctgat aagttg                                 36


<210>  939
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  939
tggggcccgg gcaccctcgt caccgtctcg agc                                    33


<210>  940
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  940
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  941
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  941

Ala Ile Lys Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Asp Ile Tyr Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Asp Gly Thr Gln Phe Thr Leu Thr Ile Ser Ala Val Gln Cys 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Val Ala Trp Ser Ser Asn 
                85                  90                  95      


Thr Gly Tyr Gly Ser Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  942
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  942

Ala Ile Lys Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Asp Ile Tyr Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Asp Gly Thr Gln Phe Thr Leu Thr Ile Ser Ala Val Gln Cys 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Val Ala Trp Ser Ser Asn 
                85                  90                  95      


Thr Gly Tyr Gly Ser Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg 
    


<210>  943
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  943

Ala Ile Lys Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys 
            20              


<210>  944
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  944

Gln Ala Ser Glu Asp Ile Tyr Thr Asn Leu Ala 
1               5                   10      


<210>  945
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  945

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Asn Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  946
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  946

Asp Ala Ser Asp Leu Ala Ser 
1               5           


<210>  947
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  947

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Asp Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ala Val Gln Cys Glu Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  948
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  948

Gln Gly Val Ala Trp Ser Ser Asn Thr Gly Tyr Gly Ser Ala 
1               5                   10                  


<210>  949
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  949

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  950
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  950

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  951
<211>  657
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  951
gccatcaaaa tgacccagac tccatcctcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc aggccagtga ggacatttac accaatttag cctggtatca gcagaaacca      120

gggcagcctc ccaacctcct gatctatgat gcatccgatc tggcatctgg ggtcccgtcg      180

cggttcagcg gcagtggaga tgggacacag ttcactctca ccatcagcgc cgtgcagtgt      240

gaagatgctg ccacttacta ctgtcaaggt gttgcttgga gtagtaatac tggttatggt      300

tccgctttcg gcggagggac cgaggtggtg gtcaaacgta cggtagcggc cccatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  952
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  952
gccatcaaaa tgacccagac tccatcctcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc aggccagtga ggacatttac accaatttag cctggtatca gcagaaacca      120

gggcagcctc ccaacctcct gatctatgat gcatccgatc tggcatctgg ggtcccgtcg      180

cggttcagcg gcagtggaga tgggacacag ttcactctca ccatcagcgc cgtgcagtgt      240

gaagatgctg ccacttacta ctgtcaaggt gttgcttgga gtagtaatac tggttatggt      300

tccgctttcg gcggagggac cgaggtggtg gtcaaacgt                             339


<210>  953
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  953
gccatcaaaa tgacccagac tccatcctcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgc                                                               69


<210>  954
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  954
caggccagtg aggacattta caccaattta gcc                                    33


<210>  955
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  955
tggtatcagc agaaaccagg gcagcctccc aacctcctga tctat                       45


<210>  956
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  956
gatgcatccg atctggcatc t                                                 21


<210>  957
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  957
ggggtcccgt cgcggttcag cggcagtgga gatgggacac agttcactct caccatcagc       60

gccgtgcagt gtgaagatgc tgccacttac tactgt                                 96


<210>  958
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  958
caaggtgttg cttggagtag taatactggt tatggttccg ct                          42


<210>  959
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  959
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  960
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  960
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318

<210>  961

<400>  961

000

<210>  962

<400>  962

000

<210>  963

<400>  963

000

<210>  964

<400>  964

000

<210>  965

<400>  965

000

<210>  966

<400>  966

000

<210>  967

<400>  967

000

<210>  968

<400>  968

000

<210>  969

<400>  969

000

<210>  970

<400>  970

000

<210>  971

<400>  971

000

<210>  972

<400>  972

000

<210>  973

<400>  973

000

<210>  974

<400>  974

000

<210>  975

<400>  975

000

<210>  976

<400>  976

000

<210>  977

<400>  977

000

<210>  978

<400>  978

000

<210>  979

<400>  979

000

<210>  980

<400>  980

000

<210>  981

<400>  981

000

<210>  982

<400>  982

000

<210>  983

<400>  983

000

<210>  984

<400>  984

000

<210>  985

<400>  985

000

<210>  986

<400>  986

000

<210>  987

<400>  987

000

<210>  988

<400>  988

000

<210>  989

<400>  989

000

<210>  990

<400>  990

000

<210>  991

<400>  991

000

<210>  992

<400>  992

000

<210>  993

<400>  993

000

<210>  994

<400>  994

000

<210>  995

<400>  995

000

<210>  996

<400>  996

000

<210>  997

<400>  997

000

<210>  998

<400>  998

000

<210>  999

<400>  999

000

<210>  1000

<400>  1000

000

<210>  1001

<400>  1001

000

<210>  1002

<400>  1002

000

<210>  1003

<400>  1003

000

<210>  1004

<400>  1004

000

<210>  1005

<400>  1005

000

<210>  1006

<400>  1006

000

<210>  1007

<400>  1007

000

<210>  1008

<400>  1008

000

<210>  1009

<400>  1009

000

<210>  1010

<400>  1010

000

<210>  1011

<400>  1011

000

<210>  1012

<400>  1012

000

<210>  1013

<400>  1013

000

<210>  1014

<400>  1014

000

<210>  1015

<400>  1015

000

<210>  1016

<400>  1016

000

<210>  1017

<400>  1017

000

<210>  1018

<400>  1018

000

<210>  1019

<400>  1019

000

<210>  1020

<400>  1020

000

<210>  1021

<400>  1021

000

<210>  1022

<400>  1022

000

<210>  1023

<400>  1023

000

<210>  1024

<400>  1024

000

<210>  1025

<400>  1025

000

<210>  1026

<400>  1026

000

<210>  1027

<400>  1027

000

<210>  1028

<400>  1028

000

<210>  1029

<400>  1029

000

<210>  1030

<400>  1030

000

<210>  1031

<400>  1031

000

<210>  1032

<400>  1032

000

<210>  1033

<400>  1033

000

<210>  1034

<400>  1034

000

<210>  1035

<400>  1035

000

<210>  1036

<400>  1036

000

<210>  1037

<400>  1037

000

<210>  1038

<400>  1038

000

<210>  1039

<400>  1039

000

<210>  1040

<400>  1040

000

<210>  1041

<400>  1041

000

<210>  1042

<400>  1042

000

<210>  1043

<400>  1043

000

<210>  1044

<400>  1044

000

<210>  1045

<400>  1045

000

<210>  1046

<400>  1046

000

<210>  1047

<400>  1047

000

<210>  1048

<400>  1048

000

<210>  1049

<400>  1049

000

<210>  1050

<400>  1050

000

<210>  1051

<400>  1051

000

<210>  1052

<400>  1052

000

<210>  1053

<400>  1053

000

<210>  1054

<400>  1054

000

<210>  1055

<400>  1055

000

<210>  1056

<400>  1056

000

<210>  1057

<400>  1057

000

<210>  1058

<400>  1058

000

<210>  1059

<400>  1059

000

<210>  1060

<400>  1060

000

<210>  1061

<400>  1061

000

<210>  1062

<400>  1062

000

<210>  1063

<400>  1063

000

<210>  1064

<400>  1064

000

<210>  1065

<400>  1065

000

<210>  1066

<400>  1066

000

<210>  1067

<400>  1067

000

<210>  1068

<400>  1068

000

<210>  1069

<400>  1069

000

<210>  1070

<400>  1070

000

<210>  1071

<400>  1071

000

<210>  1072

<400>  1072

000

<210>  1073

<400>  1073

000

<210>  1074

<400>  1074

000

<210>  1075

<400>  1075

000

<210>  1076

<400>  1076

000

<210>  1077

<400>  1077

000

<210>  1078

<400>  1078

000

<210>  1079

<400>  1079

000

<210>  1080

<400>  1080

000

<210>  1081

<400>  1081

000

<210>  1082

<400>  1082

000

<210>  1083

<400>  1083

000

<210>  1084

<400>  1084

000

<210>  1085

<400>  1085

000

<210>  1086

<400>  1086

000

<210>  1087

<400>  1087

000

<210>  1088

<400>  1088

000

<210>  1089

<400>  1089

000

<210>  1090

<400>  1090

000

<210>  1091

<400>  1091

000

<210>  1092

<400>  1092

000

<210>  1093

<400>  1093

000

<210>  1094

<400>  1094

000

<210>  1095

<400>  1095

000

<210>  1096

<400>  1096

000

<210>  1097

<400>  1097

000

<210>  1098

<400>  1098

000

<210>  1099

<400>  1099

000

<210>  1100

<400>  1100

000

<210>  1101

<400>  1101

000

<210>  1102

<400>  1102

000

<210>  1103

<400>  1103

000

<210>  1104

<400>  1104

000

<210>  1105

<400>  1105

000

<210>  1106

<400>  1106

000

<210>  1107

<400>  1107

000

<210>  1108

<400>  1108

000

<210>  1109

<400>  1109

000

<210>  1110

<400>  1110

000

<210>  1111

<400>  1111

000

<210>  1112

<400>  1112

000

<210>  1113

<400>  1113

000

<210>  1114

<400>  1114

000

<210>  1115

<400>  1115

000

<210>  1116

<400>  1116

000

<210>  1117

<400>  1117

000

<210>  1118

<400>  1118

000

<210>  1119

<400>  1119

000

<210>  1120

<400>  1120

000

<210>  1121

<400>  1121

000

<210>  1122

<400>  1122

000

<210>  1123

<400>  1123

000

<210>  1124

<400>  1124

000

<210>  1125

<400>  1125

000

<210>  1126

<400>  1126

000

<210>  1127

<400>  1127

000

<210>  1128

<400>  1128

000

<210>  1129

<400>  1129

000

<210>  1130

<400>  1130

000

<210>  1131

<400>  1131

000

<210>  1132

<400>  1132

000

<210>  1133

<400>  1133

000

<210>  1134

<400>  1134

000

<210>  1135

<400>  1135

000

<210>  1136

<400>  1136

000

<210>  1137

<400>  1137

000

<210>  1138

<400>  1138

000

<210>  1139

<400>  1139

000

<210>  1140

<400>  1140

000

<210>  1141

<400>  1141

000

<210>  1142

<400>  1142

000

<210>  1143

<400>  1143

000

<210>  1144

<400>  1144

000

<210>  1145

<400>  1145

000

<210>  1146

<400>  1146

000

<210>  1147

<400>  1147

000

<210>  1148

<400>  1148

000

<210>  1149

<400>  1149

000

<210>  1150

<400>  1150

000

<210>  1151

<400>  1151

000

<210>  1152

<400>  1152

000

<210>  1153

<400>  1153

000

<210>  1154

<400>  1154

000

<210>  1155

<400>  1155

000

<210>  1156

<400>  1156

000

<210>  1157

<400>  1157

000

<210>  1158

<400>  1158

000

<210>  1159

<400>  1159

000

<210>  1160

<400>  1160

000

<210>  1161

<400>  1161

000

<210>  1162

<400>  1162

000

<210>  1163

<400>  1163

000

<210>  1164

<400>  1164

000

<210>  1165

<400>  1165

000

<210>  1166

<400>  1166

000

<210>  1167

<400>  1167

000

<210>  1168

<400>  1168

000

<210>  1169

<400>  1169

000

<210>  1170

<400>  1170

000

<210>  1171

<400>  1171

000

<210>  1172

<400>  1172

000

<210>  1173

<400>  1173

000

<210>  1174

<400>  1174

000

<210>  1175

<400>  1175

000

<210>  1176

<400>  1176

000

<210>  1177

<400>  1177

000

<210>  1178

<400>  1178

000

<210>  1179

<400>  1179

000

<210>  1180

<400>  1180

000

<210>  1181

<400>  1181

000

<210>  1182

<400>  1182

000

<210>  1183

<400>  1183

000

<210>  1184

<400>  1184

000

<210>  1185

<400>  1185

000

<210>  1186

<400>  1186

000

<210>  1187

<400>  1187

000

<210>  1188

<400>  1188

000

<210>  1189

<400>  1189

000

<210>  1190

<400>  1190

000

<210>  1191

<400>  1191

000

<210>  1192

<400>  1192

000

<210>  1193

<400>  1193

000

<210>  1194

<400>  1194

000

<210>  1195

<400>  1195

000

<210>  1196

<400>  1196

000

<210>  1197

<400>  1197

000

<210>  1198

<400>  1198

000

<210>  1199

<400>  1199

000

<210>  1200

<400>  1200

000

<210>  1201

<400>  1201

000

<210>  1202

<400>  1202

000

<210>  1203

<400>  1203

000

<210>  1204

<400>  1204

000

<210>  1205

<400>  1205

000

<210>  1206

<400>  1206

000

<210>  1207

<400>  1207

000

<210>  1208

<400>  1208

000

<210>  1209

<400>  1209

000

<210>  1210

<400>  1210

000

<210>  1211

<400>  1211

000

<210>  1212

<400>  1212

000

<210>  1213

<400>  1213

000

<210>  1214

<400>  1214

000

<210>  1215

<400>  1215

000

<210>  1216

<400>  1216

000

<210>  1217

<400>  1217

000

<210>  1218

<400>  1218

000

<210>  1219

<400>  1219

000

<210>  1220

<400>  1220

000

<210>  1221

<400>  1221

000

<210>  1222

<400>  1222

000

<210>  1223

<400>  1223

000

<210>  1224

<400>  1224

000

<210>  1225

<400>  1225

000

<210>  1226

<400>  1226

000

<210>  1227

<400>  1227

000

<210>  1228

<400>  1228

000

<210>  1229

<400>  1229

000

<210>  1230

<400>  1230

000

<210>  1231

<400>  1231

000

<210>  1232

<400>  1232

000

<210>  1233

<400>  1233

000

<210>  1234

<400>  1234

000

<210>  1235

<400>  1235

000

<210>  1236

<400>  1236

000

<210>  1237

<400>  1237

000

<210>  1238

<400>  1238

000

<210>  1239

<400>  1239

000

<210>  1240

<400>  1240

000

<210>  1241
<211>  38
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  AMIDATION

<400>  1241

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  1242
<211>  27
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  AMIDATION

<400>  1242

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu 
            20                  25          


<210>  1243
<211>  28
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  AMIDATION

<400>  1243

His Ser Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn 
            20                  25              


<210>  1244
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1244

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  1245
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1245

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  1246
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1246

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 



