                         SEQUENCE LISTING

<110>  Alder Biopharmaceuticals, Inc.
       University of Iowa Research Foundation
 
<120>  USE OF ANTI-PACAP ANTIBODIES AND ANTIGEN BINDING
        FRAGMENTS THEREOF FOR TREATMENT, PREVENTION, OR INHIBITION OF 
       PHOTOPHOBIA 

<130>  43257.6513

<140>  PCT/US2016/027981
<141>  2016-04-15

<150>  62/148550
<151>  2015-04-16

<150>  62/148557
<151>  2015-04-16

<150>  62/148562
<151>  2015-04-16

<150>  62/148583
<151>  2015-04-16

<150>  62/148596
<151>  2015-04-16

<150>  62/148640
<151>  2015-04-16

<150>  62/148643
<151>  2015-04-16

<160>  1246   

<170>  PatentIn version 3.5


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<210>  401
<211>  439
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  401

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Asn Ser Tyr Tyr 
            20                  25                  30          


Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Phe Ile Asp Ala Gly Gly Asp Ala Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Leu 
                85                  90                  95      


Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
            100                 105                 110         


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
        115                 120                 125             


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
    130                 135                 140                 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
145                 150                 155                 160 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
                165                 170                 175     


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
            180                 185                 190         


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala Arg Val Glu 
        195                 200                 205             


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    210                 215                 220                 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
225                 230                 235                 240 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                245                 250                 255     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            260                 265                 270         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        275                 280                 285             


Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    290                 295                 300                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
305                 310                 315                 320 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                325                 330                 335     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            340                 345                 350         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        355                 360                 365             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    370                 375                 380                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
385                 390                 395                 400 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                405                 410                 415     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            420                 425                 430         


Leu Ser Leu Ser Pro Gly Lys 
        435                 


<210>  402
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  402

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Asn Ser Tyr Tyr 
            20                  25                  30          


Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Phe Ile Asp Ala Gly Gly Asp Ala Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Leu 
                85                  90                  95      


Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 


<210>  403
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  403

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Asn 
            20                  25                  


<210>  404
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  404

Ser Tyr Tyr Met Thr 
1               5   


<210>  405
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  405

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  406
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  406

Phe Ile Asp Ala Gly Gly Asp Ala Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  407
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  407

Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
1               5                   10                  15      


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  408
<211>  4
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  408

Asp Leu Asp Leu 
1               


<210>  409
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  409

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  410
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  410

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  411
<211>  1317
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  411
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggaatcga cctcaatagc tactacatga cctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggattcatt gatgctggtg gtgacgcata ctacgcgagc      180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatcacc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gagatcttga cttgtggggc      300

cagggcaccc tggtcaccgt ctcgagcgcc tccaccaagg gcccatcggt cttccccctg      360

gcaccctcct ccaagagcac ctctgggggc acagcggccc tgggctgcct ggtcaaggac      420

tacttccccg aaccggtgac ggtgtcgtgg aactcaggcg ccctgaccag cggcgtgcac      480

accttcccgg ctgtcctaca gtcctcagga ctctactccc tcagcagcgt ggtgaccgtg      540

ccctccagca gcttgggcac ccagacctac atctgcaacg tgaatcacaa gcccagcaac      600

accaaggtgg acgcgagagt tgagcccaaa tcttgtgaca aaactcacac atgcccaccg      660

tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag      720

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      780

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag      840

acaaagccgc gggaggagca gtacgccagc acgtaccgtg tggtcagcgt cctcaccgtc      900

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc      960

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1020

tacaccctgc ccccatcccg ggaggagatg accaagaacc aggtcagcct gacctgcctg     1080

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1140

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1200

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1260

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaa        1317


<210>  412
<211>  327
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  412
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggaatcga cctcaatagc tactacatga cctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggattcatt gatgctggtg gtgacgcata ctacgcgagc      180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatcacc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gagatcttga cttgtggggc      300

cagggcaccc tggtcaccgt ctcgagc                                          327


<210>  413
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  413
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggaatcga cctcaat                                           87


<210>  414
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  414
agctactaca tgacc                                                        15


<210>  415
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  415
tgggtccgcc aggctccagg gaaggggctg gaatggatcg ga                          42


<210>  416
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  416
ttcattgatg ctggtggtga cgcatactac gcgagctggg cgaaaggc                    48


<210>  417
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  417
cgattcacca tctccaaaac ctcgaccacg gtggatctga aaatcaccag tccgacaacc       60

gaggacacgg ccacctattt ctgtgccaga                                        90


<210>  418
<211>  12
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  418
gatcttgact tg                                                           12


<210>  419
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  419
tggggccagg gcaccctggt caccgtctcg agc                                    33


<210>  420
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  420
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  421
<211>  216
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  421

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Glu Ser Val Tyr Gly Asn 
            20                  25                  30          


Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Ala Ser Lys Leu Glu Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Gln 
65                  70                  75                  80  


Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Asp Ile Ser Glu 
                85                  90                  95      


Gly Val Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  422
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  422

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Glu Ser Val Tyr Gly Asn 
            20                  25                  30          


Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Ala Ser Lys Leu Glu Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Gln 
65                  70                  75                  80  


Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Asp Ile Ser Glu 
                85                  90                  95      


Gly Val Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110 


<210>  423
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  423

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys 
            20              


<210>  424
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  424

Gln Ser Ser Glu Ser Val Tyr Gly Asn Tyr Leu Ala 
1               5                   10          


<210>  425
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  425

Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  426
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  426

Glu Ala Ser Lys Leu Glu Ser 
1               5           


<210>  427
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  427

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  428
<211>  10
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  428

Ala Gly Gly Asp Ile Ser Glu Gly Val Ala 
1               5                   10  


<210>  429
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  429

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  430
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  430

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  431
<211>  648
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  431
gccgccgtgc tgacccagac tccatctccc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc agtccagtga gagtgtttac ggtaactact tagcctggtt tcagcagaaa      120

ccagggcagc ctcccaagct cctgatctac gaagcatcca aactggaatc tggggtccca      180

tcgcggttca gcggcagtgg atctgggaca cagttcactc tcaccatcag cgacttgcag      240

tgtgacgatg ctgccactta ctactgtgca ggcggtgata ttagtgaagg tgttgctttc      300

ggcggaggga ccgaggtggt ggtcaaacgt acggtagcgg ccccatctgt cttcatcttc      360

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      420

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      480

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      540

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      600

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                   648


<210>  432
<211>  330
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  432
gccgccgtgc tgacccagac tccatctccc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc agtccagtga gagtgtttac ggtaactact tagcctggtt tcagcagaaa      120

ccagggcagc ctcccaagct cctgatctac gaagcatcca aactggaatc tggggtccca      180

tcgcggttca gcggcagtgg atctgggaca cagttcactc tcaccatcag cgacttgcag      240

tgtgacgatg ctgccactta ctactgtgca ggcggtgata ttagtgaagg tgttgctttc      300

ggcggaggga ccgaggtggt ggtcaaacgt                                       330


<210>  433
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  433
gccgccgtgc tgacccagac tccatctccc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgc                                                               69


<210>  434
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  434
cagtccagtg agagtgttta cggtaactac ttagcc                                 36


<210>  435
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  435
tggtttcagc agaaaccagg gcagcctccc aagctcctga tctac                       45


<210>  436
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  436
gaagcatcca aactggaatc t                                                 21


<210>  437
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  437
ggggtcccat cgcggttcag cggcagtgga tctgggacac agttcactct caccatcagc       60

gacttgcagt gtgacgatgc tgccacttac tactgt                                 96


<210>  438
<211>  30
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  438
gcaggcggtg atattagtga aggtgttgct                                        30


<210>  439
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  439
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  440
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  440
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  441
<211>  439
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  441

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Tyr Tyr 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Phe Ile Asp Thr Asp Gly Ser Ala Tyr Tyr Ala Thr Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Leu 
                85                  90                  95      


Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
            100                 105                 110         


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
        115                 120                 125             


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
    130                 135                 140                 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
145                 150                 155                 160 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
                165                 170                 175     


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
            180                 185                 190         


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
        195                 200                 205             


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    210                 215                 220                 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
225                 230                 235                 240 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                245                 250                 255     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            260                 265                 270         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        275                 280                 285             


Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    290                 295                 300                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
305                 310                 315                 320 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                325                 330                 335     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            340                 345                 350         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        355                 360                 365             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    370                 375                 380                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
385                 390                 395                 400 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                405                 410                 415     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            420                 425                 430         


Leu Ser Leu Ser Pro Gly Lys 
        435                 


<210>  442
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  442

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Tyr Tyr 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Phe Ile Asp Thr Asp Gly Ser Ala Tyr Tyr Ala Thr Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Leu 
                85                  90                  95      


Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 


<210>  443
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  443

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser 
            20                  25                  


<210>  444
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  444

Ser Tyr Tyr Met Ser 
1               5   


<210>  445
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  445

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  446
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  446

Phe Ile Asp Thr Asp Gly Ser Ala Tyr Tyr Ala Thr Trp Ala Lys Gly 
1               5                   10                  15      


<210>  447
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  447

Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
1               5                   10                  15      


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  448
<211>  4
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  448

Asp Leu Asp Leu 
1               


<210>  449
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  449

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  450
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  450

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  451
<211>  1317
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  451
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggaatcga cctcagtagc tactacatga gctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggattcatt gatactgatg gtagcgcata ctacgcgacc      180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatcacc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gagatcttga cttgtggggc      300

ccgggcaccc tcgtcaccgt ctcgagcgcc tccaccaagg gcccatcggt cttccccctg      360

gcaccctcct ccaagagcac ctctgggggc acagcggccc tgggctgcct ggtcaaggac      420

tacttccccg aaccggtgac ggtgtcgtgg aactcaggcg ccctgaccag cggcgtgcac      480

accttcccgg ctgtcctaca gtcctcagga ctctactccc tcagcagcgt ggtgaccgtg      540

ccctccagca gcttgggcac ccagacctac atctgcaacg tgaatcacaa gcccagcaac      600

accaaggtgg acaagaaagt tgagcccaaa tcttgtgaca aaactcacac atgcccaccg      660

tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag      720

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      780

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag      840

acaaagccgc gggaggagca gtacgccagc acgtaccgtg tggtcagcgt cctcaccgtc      900

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc      960

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1020

tacaccctgc ccccatcccg ggaggagatg accaagaacc aggtcagcct gacctgcctg     1080

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1140

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1200

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1260

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaa        1317


<210>  452
<211>  327
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  452
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggaatcga cctcagtagc tactacatga gctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggattcatt gatactgatg gtagcgcata ctacgcgacc      180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatcacc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gagatcttga cttgtggggc      300

ccgggcaccc tcgtcaccgt ctcgagc                                          327


<210>  453
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  453
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggaatcga cctcagt                                           87


<210>  454
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  454
agctactaca tgagc                                                        15


<210>  455
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  455
tgggtccgcc aggctccagg gaaggggctg gaatggatcg ga                          42


<210>  456
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  456
ttcattgata ctgatggtag cgcatactac gcgacctggg cgaaaggc                    48


<210>  457
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  457
cgattcacca tctccaaaac ctcgaccacg gtggatctga aaatcaccag tccgacaacc       60

gaggacacgg ccacctattt ctgtgccaga                                        90


<210>  458
<211>  12
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  458
gatcttgact tg                                                           12


<210>  459
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  459
tggggcccgg gcaccctcgt caccgtctcg agc                                    33


<210>  460
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  460
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  461
<211>  216
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  461

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Ser Ile Ser Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn 
            20                  25                  30          


Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Phe Leu 
        35                  40                  45              


Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val Gln 
65                  70                  75                  80  


Cys Asp Asp Ala Gly Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Ser Glu 
                85                  90                  95      


Gly Val Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  462
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  462

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Ser Ile Ser Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn 
            20                  25                  30          


Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Phe Leu 
        35                  40                  45              


Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val Gln 
65                  70                  75                  80  


Cys Asp Asp Ala Gly Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Ser Glu 
                85                  90                  95      


Gly Val Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110 


<210>  463
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  463

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Ser Ile Ser Cys 
            20              


<210>  464
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  464

Gln Ser Ser Glu Ser Val Tyr Ser Asn Tyr Leu Ala 
1               5                   10          


<210>  465
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  465

Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Phe Leu Ile Tyr 
1               5                   10                  15  


<210>  466
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  466

Glu Ala Ser Lys Leu Ala Ser 
1               5           


<210>  467
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  467

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Val Gln Cys Asp Asp Ala Gly Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  468
<211>  10
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  468

Ala Gly Gly Tyr Ser Ser Glu Gly Val Ala 
1               5                   10  


<210>  469
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  469

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  470
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  470

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  471
<211>  648
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  471
gccgccgtgc tgacccagac tccatctccc gtgtctgcag ctgtgggagg cacagtcagc       60

atcagttgcc agtccagtga gagtgtttat agtaactact tagcctggtt tcagcagaaa      120

ccagggcagc ctcctaagtt cttgatctac gaagcatcca aactggcatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca cagttcactc tcaccatcag cgacgtgcag      240

tgtgacgatg ctggcactta ctactgtgca ggcggctata gtagtgaagg tgttgctttc      300

ggcggaggga ccgaggtggt ggtcaaacgt acggtagcgg ccccatctgt cttcatcttc      360

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      420

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      480

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      540

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      600

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                   648


<210>  472
<211>  330
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  472
gccgccgtgc tgacccagac tccatctccc gtgtctgcag ctgtgggagg cacagtcagc       60

atcagttgcc agtccagtga gagtgtttat agtaactact tagcctggtt tcagcagaaa      120

ccagggcagc ctcctaagtt cttgatctac gaagcatcca aactggcatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca cagttcactc tcaccatcag cgacgtgcag      240

tgtgacgatg ctggcactta ctactgtgca ggcggctata gtagtgaagg tgttgctttc      300

ggcggaggga ccgaggtggt ggtcaaacgt                                       330


<210>  473
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  473
gccgccgtgc tgacccagac tccatctccc gtgtctgcag ctgtgggagg cacagtcagc       60

atcagttgc                                                               69


<210>  474
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  474
cagtccagtg agagtgttta tagtaactac ttagcc                                 36


<210>  475
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  475
tggtttcagc agaaaccagg gcagcctcct aagttcttga tctac                       45


<210>  476
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  476
gaagcatcca aactggcatc t                                                 21


<210>  477
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  477
ggggtcccat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcagc       60

gacgtgcagt gtgacgatgc tggcacttac tactgt                                 96


<210>  478
<211>  30
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  478
gcaggcggct atagtagtga aggtgttgct                                        30


<210>  479
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  479
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  480
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  480
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318

<210>  481

<400>  481
000

<210>  482

<400>  482
000

<210>  483

<400>  483
000

<210>  484

<400>  484
000

<210>  485

<400>  485
000

<210>  486

<400>  486
000

<210>  487

<400>  487
000

<210>  488

<400>  488
000

<210>  489

<400>  489
000

<210>  490

<400>  490
000

<210>  491

<400>  491
000

<210>  492

<400>  492
000

<210>  493

<400>  493
000

<210>  494

<400>  494
000

<210>  495

<400>  495
000

<210>  496

<400>  496
000

<210>  497

<400>  497
000

<210>  498

<400>  498
000

<210>  499

<400>  499
000

<210>  500

<400>  500
000

<210>  501

<400>  501
000

<210>  502

<400>  502
000

<210>  503

<400>  503
000

<210>  504

<400>  504
000

<210>  505

<400>  505
000

<210>  506

<400>  506
000

<210>  507

<400>  507
000

<210>  508

<400>  508
000

<210>  509

<400>  509
000

<210>  510

<400>  510
000

<210>  511

<400>  511
000

<210>  512

<400>  512
000

<210>  513

<400>  513
000

<210>  514

<400>  514
000

<210>  515

<400>  515
000

<210>  516

<400>  516
000

<210>  517

<400>  517
000

<210>  518

<400>  518
000

<210>  519

<400>  519
000

<210>  520

<400>  520
000

<210>  521

<400>  521
000

<210>  522

<400>  522
000

<210>  523

<400>  523
000

<210>  524

<400>  524
000

<210>  525

<400>  525
000

<210>  526

<400>  526
000

<210>  527

<400>  527
000

<210>  528

<400>  528
000

<210>  529

<400>  529
000

<210>  530

<400>  530
000

<210>  531

<400>  531
000

<210>  532

<400>  532
000

<210>  533

<400>  533
000

<210>  534

<400>  534
000

<210>  535

<400>  535
000

<210>  536

<400>  536
000

<210>  537

<400>  537
000

<210>  538

<400>  538
000

<210>  539

<400>  539
000

<210>  540

<400>  540
000

<210>  541

<400>  541
000

<210>  542

<400>  542
000

<210>  543

<400>  543
000

<210>  544

<400>  544
000

<210>  545

<400>  545
000

<210>  546

<400>  546
000

<210>  547

<400>  547
000

<210>  548

<400>  548
000

<210>  549

<400>  549
000

<210>  550

<400>  550
000

<210>  551

<400>  551
000

<210>  552

<400>  552
000

<210>  553

<400>  553
000

<210>  554

<400>  554
000

<210>  555

<400>  555
000

<210>  556

<400>  556
000

<210>  557

<400>  557
000

<210>  558

<400>  558
000

<210>  559

<400>  559
000

<210>  560

<400>  560
000

<210>  561

<400>  561
000

<210>  562

<400>  562
000

<210>  563

<400>  563
000

<210>  564

<400>  564
000

<210>  565

<400>  565
000

<210>  566

<400>  566
000

<210>  567

<400>  567
000

<210>  568

<400>  568
000

<210>  569

<400>  569
000

<210>  570

<400>  570
000

<210>  571

<400>  571
000

<210>  572

<400>  572
000

<210>  573

<400>  573
000

<210>  574

<400>  574
000

<210>  575

<400>  575
000

<210>  576

<400>  576
000

<210>  577

<400>  577
000

<210>  578

<400>  578
000

<210>  579

<400>  579
000

<210>  580

<400>  580
000

<210>  581

<400>  581
000

<210>  582

<400>  582
000

<210>  583

<400>  583
000

<210>  584

<400>  584
000

<210>  585

<400>  585
000

<210>  586

<400>  586
000

<210>  587

<400>  587
000

<210>  588

<400>  588
000

<210>  589

<400>  589
000

<210>  590

<400>  590
000

<210>  591

<400>  591
000

<210>  592

<400>  592
000

<210>  593

<400>  593
000

<210>  594

<400>  594
000

<210>  595

<400>  595
000

<210>  596

<400>  596
000

<210>  597

<400>  597
000

<210>  598

<400>  598
000

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000

<210>  1061

<400>  1061
000

<210>  1062

<400>  1062
000

<210>  1063

<400>  1063
000

<210>  1064

<400>  1064
000

<210>  1065

<400>  1065
000

<210>  1066

<400>  1066
000

<210>  1067

<400>  1067
000

<210>  1068

<400>  1068
000

<210>  1069

<400>  1069
000

<210>  1070

<400>  1070
000

<210>  1071

<400>  1071
000

<210>  1072

<400>  1072
000

<210>  1073

<400>  1073
000

<210>  1074

<400>  1074
000

<210>  1075

<400>  1075
000

<210>  1076

<400>  1076
000

<210>  1077

<400>  1077
000

<210>  1078

<400>  1078
000

<210>  1079

<400>  1079
000

<210>  1080

<400>  1080
000

<210>  1081

<400>  1081
000

<210>  1082

<400>  1082
000

<210>  1083

<400>  1083
000

<210>  1084

<400>  1084
000

<210>  1085

<400>  1085
000

<210>  1086

<400>  1086
000

<210>  1087

<400>  1087
000

<210>  1088

<400>  1088
000

<210>  1089

<400>  1089
000

<210>  1090

<400>  1090
000

<210>  1091

<400>  1091
000

<210>  1092

<400>  1092
000

<210>  1093

<400>  1093
000

<210>  1094

<400>  1094
000

<210>  1095

<400>  1095
000

<210>  1096

<400>  1096
000

<210>  1097

<400>  1097
000

<210>  1098

<400>  1098
000

<210>  1099

<400>  1099
000

<210>  1100

<400>  1100
000

<210>  1101

<400>  1101
000

<210>  1102

<400>  1102
000

<210>  1103

<400>  1103
000

<210>  1104

<400>  1104
000

<210>  1105

<400>  1105
000

<210>  1106

<400>  1106
000

<210>  1107

<400>  1107
000

<210>  1108

<400>  1108
000

<210>  1109

<400>  1109
000

<210>  1110

<400>  1110
000

<210>  1111

<400>  1111
000

<210>  1112

<400>  1112
000

<210>  1113

<400>  1113
000

<210>  1114

<400>  1114
000

<210>  1115

<400>  1115
000

<210>  1116

<400>  1116
000

<210>  1117

<400>  1117
000

<210>  1118

<400>  1118
000

<210>  1119

<400>  1119
000

<210>  1120

<400>  1120
000

<210>  1121

<400>  1121
000

<210>  1122

<400>  1122
000

<210>  1123

<400>  1123
000

<210>  1124

<400>  1124
000

<210>  1125

<400>  1125
000

<210>  1126

<400>  1126
000

<210>  1127

<400>  1127
000

<210>  1128

<400>  1128
000

<210>  1129

<400>  1129
000

<210>  1130

<400>  1130
000

<210>  1131

<400>  1131
000

<210>  1132

<400>  1132
000

<210>  1133

<400>  1133
000

<210>  1134

<400>  1134
000

<210>  1135

<400>  1135
000

<210>  1136

<400>  1136
000

<210>  1137

<400>  1137
000

<210>  1138

<400>  1138
000

<210>  1139

<400>  1139
000

<210>  1140

<400>  1140
000

<210>  1141

<400>  1141
000

<210>  1142

<400>  1142
000

<210>  1143

<400>  1143
000

<210>  1144

<400>  1144
000

<210>  1145

<400>  1145
000

<210>  1146

<400>  1146
000

<210>  1147

<400>  1147
000

<210>  1148

<400>  1148
000

<210>  1149

<400>  1149
000

<210>  1150

<400>  1150
000

<210>  1151

<400>  1151
000

<210>  1152

<400>  1152
000

<210>  1153

<400>  1153
000

<210>  1154

<400>  1154
000

<210>  1155

<400>  1155
000

<210>  1156

<400>  1156
000

<210>  1157

<400>  1157
000

<210>  1158

<400>  1158
000

<210>  1159

<400>  1159
000

<210>  1160

<400>  1160
000

<210>  1161

<400>  1161
000

<210>  1162

<400>  1162
000

<210>  1163

<400>  1163
000

<210>  1164

<400>  1164
000

<210>  1165

<400>  1165
000

<210>  1166

<400>  1166
000

<210>  1167

<400>  1167
000

<210>  1168

<400>  1168
000

<210>  1169

<400>  1169
000

<210>  1170

<400>  1170
000

<210>  1171

<400>  1171
000

<210>  1172

<400>  1172
000

<210>  1173

<400>  1173
000

<210>  1174

<400>  1174
000

<210>  1175

<400>  1175
000

<210>  1176

<400>  1176
000

<210>  1177

<400>  1177
000

<210>  1178

<400>  1178
000

<210>  1179

<400>  1179
000

<210>  1180

<400>  1180
000

<210>  1181

<400>  1181
000

<210>  1182

<400>  1182
000

<210>  1183

<400>  1183
000

<210>  1184

<400>  1184
000

<210>  1185

<400>  1185
000

<210>  1186

<400>  1186
000

<210>  1187

<400>  1187
000

<210>  1188

<400>  1188
000

<210>  1189

<400>  1189
000

<210>  1190

<400>  1190
000

<210>  1191

<400>  1191
000

<210>  1192

<400>  1192
000

<210>  1193

<400>  1193
000

<210>  1194

<400>  1194
000

<210>  1195

<400>  1195
000

<210>  1196

<400>  1196
000

<210>  1197

<400>  1197
000

<210>  1198

<400>  1198
000

<210>  1199

<400>  1199
000

<210>  1200

<400>  1200
000

<210>  1201

<400>  1201
000

<210>  1202

<400>  1202
000

<210>  1203

<400>  1203
000

<210>  1204

<400>  1204
000

<210>  1205

<400>  1205
000

<210>  1206

<400>  1206
000

<210>  1207

<400>  1207
000

<210>  1208

<400>  1208
000

<210>  1209

<400>  1209
000

<210>  1210

<400>  1210
000

<210>  1211

<400>  1211
000

<210>  1212

<400>  1212
000

<210>  1213

<400>  1213
000

<210>  1214

<400>  1214
000

<210>  1215

<400>  1215
000

<210>  1216

<400>  1216
000

<210>  1217

<400>  1217
000

<210>  1218

<400>  1218
000

<210>  1219

<400>  1219
000

<210>  1220

<400>  1220
000

<210>  1221

<400>  1221
000

<210>  1222

<400>  1222
000

<210>  1223

<400>  1223
000

<210>  1224

<400>  1224
000

<210>  1225

<400>  1225
000

<210>  1226

<400>  1226
000

<210>  1227

<400>  1227
000

<210>  1228

<400>  1228
000

<210>  1229

<400>  1229
000

<210>  1230

<400>  1230
000

<210>  1231

<400>  1231
000

<210>  1232

<400>  1232
000

<210>  1233

<400>  1233
000

<210>  1234

<400>  1234
000

<210>  1235

<400>  1235
000

<210>  1236

<400>  1236
000

<210>  1237

<400>  1237
000

<210>  1238

<400>  1238
000

<210>  1239

<400>  1239
000

<210>  1240

<400>  1240
000

<210>  1241
<211>  38
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  AMIDATION

<400>  1241

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  1242
<211>  27
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  AMIDATION

<400>  1242

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu 
            20                  25          


<210>  1243
<211>  28
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  AMIDATION

<400>  1243

His Ser Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn 
            20                  25              


<210>  1244
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1244

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  1245
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1245

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  1246
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1246

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

