                         SEQUENCE LISTING

<110>  Emory University
       CHILDREN'S HEALTHCARE OF ATLANTA, INC.
       Doering, Christopher
       Spencer, H Trent
       Brown, Harrison C
 
<120>  RECOMBINANT PROMOTERS AND VECTORS FOR PROTEIN EXPRESSION IN LIVER
        AND USE THEREOF

<130>  6975-96747-04

<150>  US 62/202,133
<151>  2015-08-06

<150>  US 62/212,634
<151>  2015-09-01

<150>  US 62/148,696
<151>  2015-04-16

<160>  131   

<170>  PatentIn version 3.5

<210>  1
<211>  2351
<212>  PRT
<213>  homo sapiens

<400>  1

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              


Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  


Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  


Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      


Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         


His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             


Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 


Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 


Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     


Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         


Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             


Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 


Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 


Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     


Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         


Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             


Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 


Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 


Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     


Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         


Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             


Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         


Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         


Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         


Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro 
        755                 760                 765             


Ser Thr Arg Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp 
    770                 775                 780                 


Ile Glu Lys Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys 
785                 790                 795                 800 


Ile Gln Asn Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser 
                805                 810                 815     


Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr 
            820                 825                 830         


Glu Thr Phe Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn 
        835                 840                 845             


Ser Leu Ser Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly 
    850                 855                 860                 


Asp Met Val Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu 
865                 870                 875                 880 


Lys Leu Gly Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys 
                885                 890                 895     


Val Ser Ser Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn 
            900                 905                 910         


Leu Ala Ala Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met 
        915                 920                 925             


Pro Val His Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys 
    930                 935                 940                 


Ser Ser Pro Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu 
945                 950                 955                 960 


Asn Asn Asp Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu 
                965                 970                 975     


Ser Ser Trp Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe 
            980                 985                 990         


Lys Gly Lys Arg Ala His Gly Pro  Ala Leu Leu Thr Lys  Asp Asn Ala 
        995                 1000                 1005             


Leu Phe  Lys Val Ser Ile Ser  Leu Leu Lys Thr Asn  Lys Thr Ser 
    1010                 1015                 1020             


Asn Asn  Ser Ala Thr Asn Arg  Lys Thr His Ile Asp  Gly Pro Ser 
    1025                 1030                 1035             


Leu Leu  Ile Glu Asn Ser Pro  Ser Val Trp Gln Asn  Ile Leu Glu 
    1040                 1045                 1050             


Ser Asp  Thr Glu Phe Lys Lys  Val Thr Pro Leu Ile  His Asp Arg 
    1055                 1060                 1065             


Met Leu  Met Asp Lys Asn Ala  Thr Ala Leu Arg Leu  Asn His Met 
    1070                 1075                 1080             


Ser Asn  Lys Thr Thr Ser Ser  Lys Asn Met Glu Met  Val Gln Gln 
    1085                 1090                 1095             


Lys Lys  Glu Gly Pro Ile Pro  Pro Asp Ala Gln Asn  Pro Asp Met 
    1100                 1105                 1110             


Ser Phe  Phe Lys Met Leu Phe  Leu Pro Glu Ser Ala  Arg Trp Ile 
    1115                 1120                 1125             


Gln Arg  Thr His Gly Lys Asn  Ser Leu Asn Ser Gly  Gln Gly Pro 
    1130                 1135                 1140             


Ser Pro  Lys Gln Leu Val Ser  Leu Gly Pro Glu Lys  Ser Val Glu 
    1145                 1150                 1155             


Gly Gln  Asn Phe Leu Ser Glu  Lys Asn Lys Val Val  Val Gly Lys 
    1160                 1165                 1170             


Gly Glu  Phe Thr Lys Asp Val  Gly Leu Lys Glu Met  Val Phe Pro 
    1175                 1180                 1185             


Ser Ser  Arg Asn Leu Phe Leu  Thr Asn Leu Asp Asn  Leu His Glu 
    1190                 1195                 1200             


Asn Asn  Thr His Asn Gln Glu  Lys Lys Ile Gln Glu  Glu Ile Glu 
    1205                 1210                 1215             


Lys Lys  Glu Thr Leu Ile Gln  Glu Asn Val Val Leu  Pro Gln Ile 
    1220                 1225                 1230             


His Thr  Val Thr Gly Thr Lys  Asn Phe Met Lys Asn  Leu Phe Leu 
    1235                 1240                 1245             


Leu Ser  Thr Arg Gln Asn Val  Glu Gly Ser Tyr Asp  Gly Ala Tyr 
    1250                 1255                 1260             


Ala Pro  Val Leu Gln Asp Phe  Arg Ser Leu Asn Asp  Ser Thr Asn 
    1265                 1270                 1275             


Arg Thr  Lys Lys His Thr Ala  His Phe Ser Lys Lys  Gly Glu Glu 
    1280                 1285                 1290             


Glu Asn  Leu Glu Gly Leu Gly  Asn Gln Thr Lys Gln  Ile Val Glu 
    1295                 1300                 1305             


Lys Tyr  Ala Cys Thr Thr Arg  Ile Ser Pro Asn Thr  Ser Gln Gln 
    1310                 1315                 1320             


Asn Phe  Val Thr Gln Arg Ser  Lys Arg Ala Leu Lys  Gln Phe Arg 
    1325                 1330                 1335             


Leu Pro  Leu Glu Glu Thr Glu  Leu Glu Lys Arg Ile  Ile Val Asp 
    1340                 1345                 1350             


Asp Thr  Ser Thr Gln Trp Ser  Lys Asn Met Lys His  Leu Thr Pro 
    1355                 1360                 1365             


Ser Thr  Leu Thr Gln Ile Asp  Tyr Asn Glu Lys Glu  Lys Gly Ala 
    1370                 1375                 1380             


Ile Thr  Gln Ser Pro Leu Ser  Asp Cys Leu Thr Arg  Ser His Ser 
    1385                 1390                 1395             


Ile Pro  Gln Ala Asn Arg Ser  Pro Leu Pro Ile Ala  Lys Val Ser 
    1400                 1405                 1410             


Ser Phe  Pro Ser Ile Arg Pro  Ile Tyr Leu Thr Arg  Val Leu Phe 
    1415                 1420                 1425             


Gln Asp  Asn Ser Ser His Leu  Pro Ala Ala Ser Tyr  Arg Lys Lys 
    1430                 1435                 1440             


Asp Ser  Gly Val Gln Glu Ser  Ser His Phe Leu Gln  Gly Ala Lys 
    1445                 1450                 1455             


Lys Asn  Asn Leu Ser Leu Ala  Ile Leu Thr Leu Glu  Met Thr Gly 
    1460                 1465                 1470             


Asp Gln  Arg Glu Val Gly Ser  Leu Gly Thr Ser Ala  Thr Asn Ser 
    1475                 1480                 1485             


Val Thr  Tyr Lys Lys Val Glu  Asn Thr Val Leu Pro  Lys Pro Asp 
    1490                 1495                 1500             


Leu Pro  Lys Thr Ser Gly Lys  Val Glu Leu Leu Pro  Lys Val His 
    1505                 1510                 1515             


Ile Tyr  Gln Lys Asp Leu Phe  Pro Thr Glu Thr Ser  Asn Gly Ser 
    1520                 1525                 1530             


Pro Gly  His Leu Asp Leu Val  Glu Gly Ser Leu Leu  Gln Gly Thr 
    1535                 1540                 1545             


Glu Gly  Ala Ile Lys Trp Asn  Glu Ala Asn Arg Pro  Gly Lys Val 
    1550                 1555                 1560             


Pro Phe  Leu Arg Val Ala Thr  Glu Ser Ser Ala Lys  Thr Pro Ser 
    1565                 1570                 1575             


Lys Leu  Leu Asp Pro Leu Ala  Trp Asp Asn His Tyr  Gly Thr Gln 
    1580                 1585                 1590             


Ile Pro  Lys Glu Glu Trp Lys  Ser Gln Glu Lys Ser  Pro Glu Lys 
    1595                 1600                 1605             


Thr Ala  Phe Lys Lys Lys Asp  Thr Ile Leu Ser Leu  Asn Ala Cys 
    1610                 1615                 1620             


Glu Ser  Asn His Ala Ile Ala  Ala Ile Asn Glu Gly  Gln Asn Lys 
    1625                 1630                 1635             


Pro Glu  Ile Glu Val Thr Trp  Ala Lys Gln Gly Arg  Thr Glu Arg 
    1640                 1645                 1650             


Leu Cys  Ser Gln Asn Pro Pro  Val Leu Lys Arg His  Gln Arg Glu 
    1655                 1660                 1665             


Ile Thr  Arg Thr Thr Leu Gln  Ser Asp Gln Glu Glu  Ile Asp Tyr 
    1670                 1675                 1680             


Asp Asp  Thr Ile Ser Val Glu  Met Lys Lys Glu Asp  Phe Asp Ile 
    1685                 1690                 1695             


Tyr Asp  Glu Asp Glu Asn Gln  Ser Pro Arg Ser Phe  Gln Lys Lys 
    1700                 1705                 1710             


Thr Arg  His Tyr Phe Ile Ala  Ala Val Glu Arg Leu  Trp Asp Tyr 
    1715                 1720                 1725             


Gly Met  Ser Ser Ser Pro His  Val Leu Arg Asn Arg  Ala Gln Ser 
    1730                 1735                 1740             


Gly Ser  Val Pro Gln Phe Lys  Lys Val Val Phe Gln  Glu Phe Thr 
    1745                 1750                 1755             


Asp Gly  Ser Phe Thr Gln Pro  Leu Tyr Arg Gly Glu  Leu Asn Glu 
    1760                 1765                 1770             


His Leu  Gly Leu Leu Gly Pro  Tyr Ile Arg Ala Glu  Val Glu Asp 
    1775                 1780                 1785             


Asn Ile  Met Val Thr Phe Arg  Asn Gln Ala Ser Arg  Pro Tyr Ser 
    1790                 1795                 1800             


Phe Tyr  Ser Ser Leu Ile Ser  Tyr Glu Glu Asp Gln  Arg Gln Gly 
    1805                 1810                 1815             


Ala Glu  Pro Arg Lys Asn Phe  Val Lys Pro Asn Glu  Thr Lys Thr 
    1820                 1825                 1830             


Tyr Phe  Trp Lys Val Gln His  His Met Ala Pro Thr  Lys Asp Glu 
    1835                 1840                 1845             


Phe Asp  Cys Lys Ala Trp Ala  Tyr Phe Ser Asp Val  Asp Leu Glu 
    1850                 1855                 1860             


Lys Asp  Val His Ser Gly Leu  Ile Gly Pro Leu Leu  Val Cys His 
    1865                 1870                 1875             


Thr Asn  Thr Leu Asn Pro Ala  His Gly Arg Gln Val  Thr Val Gln 
    1880                 1885                 1890             


Glu Phe  Ala Leu Phe Phe Thr  Ile Phe Asp Glu Thr  Lys Ser Trp 
    1895                 1900                 1905             


Tyr Phe  Thr Glu Asn Met Glu  Arg Asn Cys Arg Ala  Pro Cys Asn 
    1910                 1915                 1920             


Ile Gln  Met Glu Asp Pro Thr  Phe Lys Glu Asn Tyr  Arg Phe His 
    1925                 1930                 1935             


Ala Ile  Asn Gly Tyr Ile Met  Asp Thr Leu Pro Gly  Leu Val Met 
    1940                 1945                 1950             


Ala Gln  Asp Gln Arg Ile Arg  Trp Tyr Leu Leu Ser  Met Gly Ser 
    1955                 1960                 1965             


Asn Glu  Asn Ile His Ser Ile  His Phe Ser Gly His  Val Phe Thr 
    1970                 1975                 1980             


Val Arg  Lys Lys Glu Glu Tyr  Lys Met Ala Leu Tyr  Asn Leu Tyr 
    1985                 1990                 1995             


Pro Gly  Val Phe Glu Thr Val  Glu Met Leu Pro Ser  Lys Ala Gly 
    2000                 2005                 2010             


Ile Trp  Arg Val Glu Cys Leu  Ile Gly Glu His Leu  His Ala Gly 
    2015                 2020                 2025             


Met Ser  Thr Leu Phe Leu Val  Tyr Ser Asn Lys Cys  Gln Thr Pro 
    2030                 2035                 2040             


Leu Gly  Met Ala Ser Gly His  Ile Arg Asp Phe Gln  Ile Thr Ala 
    2045                 2050                 2055             


Ser Gly  Gln Tyr Gly Gln Trp  Ala Pro Lys Leu Ala  Arg Leu His 
    2060                 2065                 2070             


Tyr Ser  Gly Ser Ile Asn Ala  Trp Ser Thr Lys Glu  Pro Phe Ser 
    2075                 2080                 2085             


Trp Ile  Lys Val Asp Leu Leu  Ala Pro Met Ile Ile  His Gly Ile 
    2090                 2095                 2100             


Lys Thr  Gln Gly Ala Arg Gln  Lys Phe Ser Ser Leu  Tyr Ile Ser 
    2105                 2110                 2115             


Gln Phe  Ile Ile Met Tyr Ser  Leu Asp Gly Lys Lys  Trp Gln Thr 
    2120                 2125                 2130             


Tyr Arg  Gly Asn Ser Thr Gly  Thr Leu Met Val Phe  Phe Gly Asn 
    2135                 2140                 2145             


Val Asp  Ser Ser Gly Ile Lys  His Asn Ile Phe Asn  Pro Pro Ile 
    2150                 2155                 2160             


Ile Ala  Arg Tyr Ile Arg Leu  His Pro Thr His Tyr  Ser Ile Arg 
    2165                 2170                 2175             


Ser Thr  Leu Arg Met Glu Leu  Met Gly Cys Asp Leu  Asn Ser Cys 
    2180                 2185                 2190             


Ser Met  Pro Leu Gly Met Glu  Ser Lys Ala Ile Ser  Asp Ala Gln 
    2195                 2200                 2205             


Ile Thr  Ala Ser Ser Tyr Phe  Thr Asn Met Phe Ala  Thr Trp Ser 
    2210                 2215                 2220             


Pro Ser  Lys Ala Arg Leu His  Leu Gln Gly Arg Ser  Asn Ala Trp 
    2225                 2230                 2235             


Arg Pro  Gln Val Asn Asn Pro  Lys Glu Trp Leu Gln  Val Asp Phe 
    2240                 2245                 2250             


Gln Lys  Thr Met Lys Val Thr  Gly Val Thr Thr Gln  Gly Val Lys 
    2255                 2260                 2265             


Ser Leu  Leu Thr Ser Met Tyr  Val Lys Glu Phe Leu  Ile Ser Ser 
    2270                 2275                 2280             


Ser Gln  Asp Gly His Gln Trp  Thr Leu Phe Phe Gln  Asn Gly Lys 
    2285                 2290                 2295             


Val Lys  Val Phe Gln Gly Asn  Gln Asp Ser Phe Thr  Pro Val Val 
    2300                 2305                 2310             


Asn Ser  Leu Asp Pro Pro Leu  Leu Thr Arg Tyr Leu  Arg Ile His 
    2315                 2320                 2325             


Pro Gln  Ser Trp Val His Gln  Ile Ala Leu Arg Met  Glu Val Leu 
    2330                 2335                 2340             


Gly Cys  Glu Ala Gln Asp Leu  Tyr 
    2345                 2350     


<210>  2
<211>  4374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant fVIII

<400>  2
atgcagattg aactgtctac ctgtttcttt ctgtgcctgc tgaggttttg tttttctgct       60

accagaagat actacctggg agctgtggaa ctgagctggg attacatgca gtctgacctg      120

ggagagctgc ctgtggatgc tagattccca cctagagtcc ctaagtcctt ccccttcaac      180

acctctgtgg tctacaagaa aaccctgttt gtggagttta cagaccacct gttcaacatt      240

gctaagccta gaccaccatg gatgggactg ctgggaccaa ccatccaggc agaggtgtat      300

gacacagtgg tcatcaccct gaaaaacatg gcttctcacc ctgtgtccct gcatgctgtg      360

ggagtctcct actggaaggc ctctgaaggg gctgagtatg atgatcagac cagccagagg      420

gaaaaagagg atgataaggt gttccctgga gggtcccata cctatgtgtg gcaggtcctg      480

aaggagaatg gaccaatggc ttctgaccct ctgtgcctga cctactctta tctgtcccat      540

gtggacctgg tcaaggatct gaactctggc ctgattgggg ctctgctggt gtgtagggaa      600

gggtccctgg ccaaggagaa aacccagacc ctgcataagt tcatcctgct gtttgctgtg      660

tttgatgaag gaaaaagctg gcactctgag accaagaact ctctgatgca ggacagggat      720

gctgcttctg ccagagcttg gcccaagatg cacacagtga atggctatgt caataggagc      780

ctgcctggac tgattggctg ccacagaaag tctgtgtatt ggcatgtcat tggaatgggc      840

accacccctg aagtgcacag catcttcctg gaggggcata cctttctggt caggaaccac      900

aggcaggcta gcctggagat ctctccaatc accttcctga cagcccagac cctgctgatg      960

gacctgggac agttcctgct gttttgccac atctccagcc accagcatga tggcatggag     1020

gcttatgtga aagtggactc ctgtcctgag gaacctcagc tgaggatgaa gaacaatgag     1080

gaagctgaag actatgatga tgacctgaca gactctgaga tggatgtggt caggtttgat     1140

gatgataact ctccctcctt tatccagatc aggtctgtgg ccaagaaaca ccctaagacc     1200

tgggtccatt acattgctgc tgaggaagag gactgggatt atgctccact ggtgctggcc     1260

cctgatgata gatcctacaa aagccagtat ctgaacaatg gaccccagag gattggcaga     1320

aagtacaaga aagtgaggtt catggcttat acagatgaga cctttaagac cagagaagcc     1380

atccagcatg agtctgggat cctgggacct ctgctgtatg gggaagtggg ggacaccctg     1440

ctgatcatct tcaagaacca ggccagcagg ccttacaata tctatccaca tggcatcaca     1500

gatgtgagac ctctgtactc caggaggctg ccaaaggggg tgaaacacct gaaggacttc     1560

ccaatcctgc ctggggaaat ctttaagtat aaatggacag tcacagtgga ggatgggccc     1620

accaagtctg accctaggtg cctgaccaga tactattctt cctttgtgaa tatggagaga     1680

gacctggctt ctggactgat tggacccctg ctgatctgtt acaaagagtc tgtggatcag     1740

aggggcaacc agatcatgtc tgacaagagg aatgtgatcc tgttctctgt ctttgatgaa     1800

aacaggtctt ggtacctgac agagaacatc cagaggttcc tgcctaatcc agctggagtg     1860

cagctggaag atcctgagtt ccaggcctct aacatcatgc attccatcaa tggctatgtg     1920

tttgactccc tgcagctgtc tgtgtgcctg catgaggtgg cttactggta tatcctgagc     1980

attggagccc agacagattt cctgtctgtg ttcttttctg gctacacctt taagcataaa     2040

atggtgtatg aggacaccct gaccctgttc ccattttctg gagaaactgt gttcatgagc     2100

atggagaatc ctgggctgtg gatcctggga tgccacaact ctgatttcag gaatagaggg     2160

atgacagccc tgctgaaagt gagctcttgt gacaagaaca caggagacta ctatgaagat     2220

agctatgagg acatctctgc ttatctgctg tccaaaaaca atgccattga gcccaggagc     2280

ttctctcaga accctccagt gctgaagagg caccagaggg agatcaccag aaccaccctg     2340

cagtctgatc aggaagagat tgactatgat gataccatct ctgtggaaat gaagaaagag     2400

gactttgata tctatgatga agatgagaac cagtctccca ggtccttcca gaagaaaacc     2460

agacattact ttattgctgc tgtggagagg ctgtgggact atggcatgtc cagctctcct     2520

catgtgctga gaaatagagc tcagtctgga tctgtcccac agttcaagaa agtggtcttc     2580

caggagttta cagatggaag ctttacccag ccactgtaca ggggagaact gaatgagcac     2640

ctggggctgc tgggacccta tatcagggct gaagtggagg ataacatcat ggtcaccttc     2700

aggaatcagg ccagcagacc ctactctttt tattccagcc tgatctccta tgaagaggac     2760

cagagacagg gagctgaacc aagaaaaaac tttgtgaagc ctaatgagac caaaacctac     2820

ttttggaagg tgcagcacca tatggcccct accaaagatg agtttgattg caaggcctgg     2880

gcttattttt ctgatgtgga tctggagaag gatgtccact ctggcctgat tgggccactg     2940

ctggtgtgtc ataccaacac cctgaatcca gctcatggaa ggcaggtgac agtccaggaa     3000

tttgccctgt tctttaccat ctttgatgag accaagagct ggtacttcac agaaaacatg     3060

gagaggaatt gcagagcccc atgtaacatc cagatggaag accccacctt caaggagaac     3120

tacagatttc atgctatcaa tgggtatatc atggataccc tgccaggact ggtcatggct     3180

caggaccaga ggatcagatg gtacctgctg agcatggggt ctaatgagaa tatccactcc     3240

atccatttct ctggacatgt gtttacagta aggaagaaag aagagtacaa gatggccctg     3300

tacaacctgt atcctggggt gtttgaaaca gtggagatgc tgccttccaa ggctgggatc     3360

tggagggtgg aatgcctgat tggggagcac ctgcatgctg gaatgtctac cctgttcctg     3420

gtgtactcca ataagtgtca gacccccctg gggatggctt ctggacatat cagggacttc     3480

cagatcacag cttctggaca gtatggacag tgggctccta agctggctag actgcactat     3540

tctggctcca tcaatgcttg gtctaccaaa gagcctttct cctggatcaa ggtggacctg     3600

ctggctccaa tgatcatcca tggcatcaaa acccaggggg ccaggcagaa gttctcttcc     3660

ctgtacatca gccagtttat catcatgtat tctctggatg ggaagaaatg gcagacctac     3720

agaggcaatt ccacagggac cctgatggtg ttctttggca atgtggacag ctctgggatc     3780

aagcacaaca tcttcaatcc ccctatcatt gccaggtaca tcagactgca cccaacccat     3840

tattccatca ggagcaccct gagaatggag ctgatggggt gtgatctgaa cagctgttct     3900

atgcccctgg gaatggagtc taaggccatc tctgatgctc agatcacagc ctccagctac     3960

ttcaccaata tgtttgctac ctggtcccca agcaaggcta gactgcatct gcagggaaga     4020

agcaatgctt ggagaccaca ggtgaacaat cccaaggagt ggctgcaggt ggacttccag     4080

aaaaccatga aggtgacagg agtcaccacc cagggagtga aaagcctgct gacctctatg     4140

tatgtcaagg agttcctgat ctcttccagc caggatgggc accagtggac cctgttcttt     4200

cagaatggaa aggtgaaagt cttccagggc aatcaggatt cctttacccc tgtggtcaac     4260

agcctggacc cacccctgct gaccaggtac ctgagaatcc acccacagtc ctgggtgcat     4320

cagattgctc tgaggatgga agtcctgggc tgtgaggccc aggacctgta ttga           4374


<210>  3
<211>  1457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant fVIII

<400>  3

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              


Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  


Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Val His Leu Phe Asn Ile 
65                  70                  75                  80  


Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      


Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         


His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             


Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 


Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 


Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     


Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         


Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             


Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 


Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 


Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     


Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         


Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             


Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 


Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 


Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     


Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         


Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             


Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         


Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         


Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         


Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu 
        755                 760                 765             


Lys Arg His Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln 
    770                 775                 780                 


Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu 
785                 790                 795                 800 


Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe 
                805                 810                 815     


Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp 
            820                 825                 830         


Asp Tyr Gly Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln 
        835                 840                 845             


Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr 
    850                 855                 860                 


Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His 
865                 870                 875                 880 


Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile 
                885                 890                 895     


Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser 
            900                 905                 910         


Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg 
        915                 920                 925             


Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val 
    930                 935                 940                 


Gln His His Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp 
945                 950                 955                 960 


Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu 
                965                 970                 975     


Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His 
            980                 985                 990         


Gly Arg Gln Val Thr Val Gln Glu  Phe Ala Leu Phe Phe  Thr Ile Phe 
        995                 1000                 1005             


Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu Asn Met  Glu Arg Asn 
    1010                 1015                 1020             


Cys Arg  Ala Pro Cys Asn Ile  Gln Met Glu Asp Pro  Thr Phe Lys 
    1025                 1030                 1035             


Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly Tyr Ile  Met Asp Thr 
    1040                 1045                 1050             


Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln Arg Ile  Arg Trp Tyr 
    1055                 1060                 1065             


Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile His Ser  Ile His Phe 
    1070                 1075                 1080             


Ser Gly  His Val Phe Thr Val  Arg Lys Lys Glu Glu  Tyr Lys Met 
    1085                 1090                 1095             


Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe Glu Thr  Val Glu Met 
    1100                 1105                 1110             


Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val Glu Cys  Leu Ile Gly 
    1115                 1120                 1125             


Glu His  Leu His Ala Gly Met  Ser Thr Leu Phe Leu  Val Tyr Ser 
    1130                 1135                 1140             


Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala Ser Gly  His Ile Arg 
    1145                 1150                 1155             


Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr Gly Gln  Trp Ala Pro 
    1160                 1165                 1170             


Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser Ile Asn  Ala Trp Ser 
    1175                 1180                 1185             


Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val Asp Leu  Leu Ala Pro 
    1190                 1195                 1200             


Met Ile  Ile His Gly Ile Lys  Thr Gln Gly Ala Arg  Gln Lys Phe 
    1205                 1210                 1215             


Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile Met Tyr  Ser Leu Asp 
    1220                 1225                 1230             


Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn Ser Thr  Gly Thr Leu 
    1235                 1240                 1245             


Met Val  Phe Phe Gly Asn Val  Asp Ser Ser Gly Ile  Lys His Asn 
    1250                 1255                 1260             


Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr Ile Arg  Leu His Pro 
    1265                 1270                 1275             


Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg Met Glu  Leu Met Gly 
    1280                 1285                 1290             


Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu Gly Met  Glu Ser Lys 
    1295                 1300                 1305             


Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser Ser Tyr  Phe Thr Asn 
    1310                 1315                 1320             


Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala Arg Leu  His Leu Gln 
    1325                 1330                 1335             


Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val Asn Asn  Pro Lys Glu 
    1340                 1345                 1350             


Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met Lys Val  Thr Gly Val 
    1355                 1360                 1365             


Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr Ser Met  Tyr Val Lys 
    1370                 1375                 1380             


Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly His Gln  Trp Thr Leu 
    1385                 1390                 1395             


Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe Gln Gly  Asn Gln Asp 
    1400                 1405                 1410             


Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp Pro Pro  Leu Leu Thr 
    1415                 1420                 1425             


Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp Val His  Gln Ile Ala 
    1430                 1435                 1440             


Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala Gln Asp  Leu Tyr 
    1445                 1450                 1455         


<210>  4
<211>  146
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  4
gttaatcatt aagtcgttaa tttttgtggc ccttgcgatg tttgctctgg ttaataatct       60

caggacaaac agaggttaat aattttccag atctctctga gcaatagtat aaaaggccag      120

cagcagcctg accacatctc atcctc                                           146


<210>  5
<211>  159
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  5
gttaattttt gtggcccttg cgatgtttgc tctggttaat aatctcagga caaacataca       60

ttttcagtca tatgtttgct cactgaaggt tactagttaa caggcatccc ttaaacagga      120

tataaaaggc cagcagcagc ctgaccacat ctcatcctc                             159


<210>  6
<211>  172
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  6
gttaattttt aaaaagcagt caaaagtcca agtggccctt gcgagcattt actctctctg       60

tttgctctgg ttaataatct caggagcaca aacagaggtt aataattttc agtcatatgt      120

ttgctcactg aaggttacta gttaacaggc atcccttaaa caggatataa aa              172


<210>  7
<211>  204
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  7
gttaattttt aaaaagcagt caaaagtcca agtggccctt gcgagcattt actctctctg       60

tttgctctgg ttaataatct caggagcaca aacagaggtt aataattttc agtcatatgt      120

ttgctcactg aaggttacta gttaacaggc atcccttaaa caggatataa aaggccagca      180

gcagcctgac cacatctcat cctc                                             204


<210>  8
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant fIX

<400>  8
atgcagaggg tgaacatgat catggctgag tctcctggac tgatcaccat ctgcctgctg       60

ggctatctgc tgtctgctga gtgtacagtg ttcctggacc atgaaaatgc taataaaatc      120

ctgaacaggc caaagaggta caattctggg aaactggagg aatttgtgca gggaaacctg      180

gagagggaat gcatggagga aaagtgtagc tttgaggaag ccagggaggt gtttgaaaat      240

acagagagga ccacagagtt ctggaaacag tatgtggatg gggatcagtg tgagtccaac      300

ccctgtctga atggagggtc ttgcaaggat gatatcaact cctatgagtg ctggtgtcct      360

tttggatttg aaggcaagaa ttgtgagctg gatgtgacct gtaacatcaa aaatgggagg      420

tgtgagcagt tctgtaagaa ctctgctgat aataaagtgg tctgcagctg tacagaaggc      480

tacaggctgg ctgagaacca gaagagctgt gaaccagctg tgcccttccc ttgtgggagg      540

gtgtctgtca gccagaccag caagctgacc agagctgagg ctgtgtttcc tgatgtggat      600

tatgtcaact ctacagaggc tgaaaccatc ctggacaaca tcacccagtc tacccagtcc      660

ttcaatgact ttaccagggt ggtgggaggg gaggatgcta agccaggaca gttcccctgg      720

caggtggtcc tgaatggcaa agtggatgct ttttgtgggg gctccattgt gaatgagaag      780

tggattgtca cagctgctca ctgtgtggaa actggggtca agatcacagt ggtggctgga      840

gagcacaaca ttgaggaaac tgaacataca gagcagaaaa ggaatgtgat cagaatcatc      900

ccccaccata actacaatgc tgctatcaac aagtataatc atgacattgc cctgctggaa      960

ctggatgagc ctctggtgct gaacagctat gtcaccccaa tctgcattgc tgacaaggag     1020

tataccaata tcttcctgaa atttgggtct ggatatgtgt ctgggtgggg aagggtcttc     1080

cacaagggaa ggtctgctct ggtgctgcag tatctgaggg tgcccctggt ggacagagct     1140

acctgcctga ggagcaccaa gttcaccatc tacaacaata tgttctgtgc tggatttcat     1200

gagggaggga gggactcctg tcagggagat tctggaggcc ctcatgtgac agaggtggaa     1260

ggcaccagct tcctgactgg catcatctct tggggggagg aatgtgctat gaaggggaaa     1320

tatggaatct ataccaaggt gtccagatat gtcaactgga tcaaggagaa aaccaagctg     1380

acctga                                                                1386


<210>  9
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant fIX

<400>  9
atgcagaggg tgaacatgat catggctgag tctcctggac tgatcaccat ctgcctgctg       60

ggctatctgc tgtctgctga gtgtacagtg ttcctggacc atgaaaatgc taataaaatc      120

ctgaacaggc caaagaggta caattctggg aaactggagg aatttgtgca gggaaacctg      180

gagagggaat gcatggagga aaagtgtagc tttgaggaag ccagggaggt gtttgaaaat      240

acagagagga ccacagagtt ctggaaacag tatgtggatg gggatcagtg tgagtccaac      300

ccctgtctga atggagggtc ttgcaaggat gatatcaact cctatgagtg ctggtgtcct      360

tttggatttg aaggcaagaa ttgtgagctg gatgtgacct gtaacatcaa aaatgggagg      420

tgtgagcagt tctgtaagaa ctctgctgat aataaagtgg tctgcagctg tacagaaggc      480

tacaggctgg ctgagaacca gaagagctgt gaaccagctg tgcccttccc ttgtgggagg      540

gtgtctgtca gccagaccag caagctgacc agagctgagg ctgtgtttcc tgatgtggat      600

tatgtcaact ctacagaggc tgaaaccatc ctggacaaca tcacccagtc tacccagtcc      660

ttcaatgact ttaccagggt ggtgggaggg gaggatgcta agccaggaca gttcccctgg      720

caggtggtcc tgaatggcaa agtggatgct ttttgtgggg gctccattgt gaatgagaag      780

tggattgtca cagctgctca ctgtgtggaa actggggtca agatcacagt ggtggctgga      840

gagcacaaca ttgaggaaac tgaacataca gagcagaaaa ggaatgtgat cagaatcatc      900

ccccaccata actacaatgc tgctatcaac aagtataatc atgacattgc cctgctggaa      960

ctggatgagc ctctggtgct gaacagctat gtcaccccaa tctgcattgc tgacaaggag     1020

tataccaata tcttcctgaa atttgggtct ggatatgtgt ctgggtgggg aagggtcttc     1080

cacaagggaa ggtctgctct ggtgctgcag tatctgaggg tgcccctggt ggacagagct     1140

acctgcctgc tgagcaccaa gttcaccatc tacaacaata tgttctgtgc tggatttcat     1200

gagggaggga gggactcctg tcagggagat tctggaggcc ctcatgtgac agaggtggaa     1260

ggcaccagct tcctgactgg catcatctct tggggggagg aatgtgctat gaaggggaaa     1320

tatggaatct ataccaaggt gtccagatat gtcaactgga tcaaggagaa aaccaagctg     1380

acctga                                                                1386


<210>  10
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant fIX

<400>  10
atgcagaggg tgaacatgat catggctgag tctcctggac tgatcaccat ctgcctgctg       60

ggctatctgc tgtctgctga gtgtacagtg ttcctggacc atgaaaatgc taataaaatc      120

ctgaacaggc caaagaggta caattctggg aaactggagg aatttgtgca gggaaacctg      180

gagagggaat gcatggagga aaagtgtagc tttgaggaag ccagggaggt gtttgaaaat      240

acagagagga ccacagagtt ctggaaacag tatgtggatg gggatcagtg tgagtccaac      300

ccctgtctga atggagggtc ttgcaaggat gatatcaact cctatgagtg ctggtgtcct      360

tttggatttg aaggcaagaa ttgtgagctg gatgtgacct gtaacatcaa aaatgggagg      420

tgtgagcagt tctgtaagaa ctctgctgat aataaagtgg tctgcagctg tacagaaggc      480

tacaggctgg ctgagaacca gaagagctgt gaaccagctg tgcccttccc ttgtgggagg      540

gtgtctgtca gccagaccag caagctgacc agagctgaga cagtgtttcc tgatgtggat      600

tatgtcaact ctacagaggc tgaaaccatc ctggacaaca tcacccagtc tacccagtcc      660

ttcaatgact ttaccagggt ggtgggaggg gaggatgcta agccaggaca gttcccctgg      720

caggtggtcc tgaatggcaa agtggatgct ttttgtgggg gctccattgt gaatgagaag      780

tggattgtca cagctgctca ctgtgtggaa actggggtca agatcacagt ggtggctgga      840

gagcacaaca ttgaggaaac tgaacataca gagcagaaaa ggaatgtgat cagaatcatc      900

ccccaccata actacaatgc tgctatcaac aagtataatc atgacattgc cctgctggaa      960

ctggatgagc ctctggtgct gaacagctat gtcaccccaa tctgcattgc tgacaaggag     1020

tataccaata tcttcctgaa atttgggtct ggatatgtgt ctgggtgggg aagggtcttc     1080

cacaagggaa ggtctgctct ggtgctgcag tatctgaggg tgcccctggt ggacagagct     1140

acctgcctgc tgagcaccaa gttcaccatc tacaacaata tgttctgtgc tggatttcat     1200

gagggaggga gggactcctg tcagggagat tctggaggcc ctcatgtgac agaggtggaa     1260

ggcaccagct tcctgactgg catcatctct tggggggagg aatgtgctat gaaggggaaa     1320

tatggaatct ataccaaggt gtccagatat gtcaactgga tcaaggagaa aaccaagctg     1380

acctga                                                                1386


<210>  11
<211>  4404
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant fVIII

<400>  11
atgcagctgg aactgtctac ctgtgtgttt ctgtgtctgc tgcctctggg gttttctgct       60

atcaggagat actatctggg agctgtggag ctgtcctggg actacaggca gtctgagctg      120

ctgagagaac tgcatgtgga taccagattc ccagctacag ctccaggagc tctgcctctg      180

ggcccatctg tgctgtacaa gaaaacagtc tttgtggagt ttacagacca gctgttctct      240

gtggccaggc caagaccacc ttggatggga ctgctgggac caaccatcca ggctgaggtg      300

tatgatacag tggtggtgac cctgaaaaac atggcctccc atcctgtgag cctgcatgct      360

gtgggggtgt ccttctggaa gtcctctgag ggagctgagt atgaagacca tacctcccag      420

agggagaaag aagatgataa ggtgctgcct ggcaaaagcc agacctatgt ctggcaggtg      480

ctgaaggaga atggaccaac tgcttctgac ccaccatgcc tgacctactc ttatctgtcc      540

catgtggatc tggtgaagga cctgaattct ggactgattg gagctctgct ggtgtgtaga      600

gagggaagcc tgaccagaga aagaacccag aacctgcatg agtttgtcct gctgtttgct      660

gtgtttgatg aagggaagag ctggcactct gccaggaatg actcctggac cagagctatg      720

gatccagctc ctgctagagc tcagcctgct atgcacacag tcaatggcta tgtgaatagg      780

tctctgccag gactgattgg ctgccataag aaatctgtct attggcatgt gattggaatg      840

ggcaccagcc ctgaggtgca ttctatcttc ctggaaggcc acacctttct ggtcaggcac      900

catagacagg cctctctgga gatctcccct ctgaccttcc tgacagctca gacctttctg      960

atggacctgg ggcagttcct gctgttttgc catatctctt cccaccatca tggaggaatg     1020

gaggctcatg tcagggtgga atcctgtgct gaggaaccac agctgagaag aaaggctgat     1080

gaggaagagg actatgatga taacctgtat gactctgata tggatgtggt gaggctggat     1140

ggggatgatg tcagcccttt catccagatc aggtctgtgg ccaagaaaca tccaaagacc     1200

tgggtccact acattgctgc tgaagaggaa gattgggact atgcccccct ggtgctggct     1260

cctgatgata gatcctacaa aagccagtat ctgaacaatg ggccccagag gattggaagg     1320

aagtacaaga aagtgaggtt catggcctat acagatgaga cctttaagac cagagaggct     1380

atccagcatg aatctgggat cctgggacct ctgctgtatg gagaagtggg ggataccctg     1440

ctgatcatct tcaagaacca ggcctccagg ccatacaata tctatcccca tggcatcaca     1500

gatgtgagac cactgtacag caggagactg cccaaggggg tcaaacacct gaaggatttc     1560

cccatcctgc ctggagagat ctttaagtat aaatggacag tcacagtgga agatgggcct     1620

accaagtctg atccaaggtg cctgaccaga tactatagct cttttgtgaa catggagaga     1680

gacctggctt ctggactgat tggacccctg ctgatctgtt acaaagagtc tgtggaccag     1740

aggggcaacc agatcatgtc tgataagaga aatgtcatcc tgttctctgt gtttgatgag     1800

aacaggagct ggtacctgac agagaacatc cagaggttcc tgccaaatcc agctggagtg     1860

cagctggagg acccagaatt tcaggcttcc aacatcatgc atagcatcaa tggctatgtg     1920

tttgatagcc tgcagctgtc tgtctgcctg catgaggtgg cctactggta tatcctgtcc     1980

attggagctc agacagactt cctgtctgtg ttctttagtg ggtacacctt taagcataaa     2040

atggtgtatg aggataccct gaccctgttc cccttttctg gggagacagt gttcatgtcc     2100

atggaaaacc ctggcctgtg gatcctgggg tgccacaact ctgacttcag gaatagagga     2160

atgacagccc tgctgaaagt gtccagctgt gataagaata caggggatta ctatgaggac     2220

tcttatgaag atatctctgc ttatctgctg agcaagaaca atgccattga gcccaggtct     2280

tttgctcaga actccagacc tccatctgct tctgctccta agccacctgt gctgagaaga     2340

catcagaggg acatctccct gcctaccttc cagccagagg aagataaaat ggactatgat     2400

gatatcttca gcacagagac caagggggaa gattttgaca tctatggaga ggatgaaaac     2460

caggatccaa gatccttcca gaagagaacc agacactact ttattgctgc tgtggagcag     2520

ctgtgggact atgggatgtc tgaaagccca agggccctga ggaacagagc tcagaatgga     2580

gaggtgccca gattcaagaa agtggtgttc agagagtttg ctgatggcag ctttacccag     2640

ccatcttaca ggggggagct gaacaagcat ctggggctgc tgggacccta tatcagagct     2700

gaggtggaag ataacatcat ggtgaccttc aagaatcagg cttctaggcc ctactccttt     2760

tattcttccc tgatctccta ccctgatgat caggagcagg gagctgaacc taggcacaac     2820

tttgtgcagc caaatgagac cagaacctac ttttggaagg tgcagcatca catggctccc     2880

acagaggatg aatttgactg caaagcttgg gcctattttt ctgatgtgga cctggagaag     2940

gatgtgcatt ctggcctgat tgggcctctg ctgatctgta gggccaacac cctgaatgct     3000

gctcatggaa gacaggtcac agtgcaggag tttgctctgt tctttaccat ctttgatgaa     3060

accaagagct ggtacttcac agagaatgtg gaaaggaatt gcagagcccc ctgtcatctg     3120

cagatggagg accctaccct gaaggaaaac tacaggttcc atgccatcaa tggatatgtc     3180

atggataccc tgcctggcct ggtcatggct cagaaccaga ggatcagatg gtacctgctg     3240

tctatgggat ccaatgagaa tatccatagc atccacttct ctggccatgt cttttctgtg     3300

aggaagaaag aggaatacaa aatggctgtg tacaatctgt atcctggggt ctttgagaca     3360

gtggaaatgc tgccaagcaa agtgggaatc tggagaattg agtgcctgat tggggaacac     3420

ctgcaggctg ggatgagcac caccttcctg gtgtactcta agaaatgtca gaccccactg     3480

gggatggcct ctggacatat cagggacttc cagatcacag cttctggaca gtatggacag     3540

tgggctccaa agctggctag actgcactat tctggctcca tcaatgcctg gtctaccaaa     3600

gagccattct cctggatcaa ggtggacctg ctggccccca tgatcatcca tggaatcaaa     3660

acccagggag ctaggcagaa gttcagctct ctgtacatct cccagtttat catcatgtat     3720

agcctggatg ggaagaaatg gcagacctac agaggcaatt ccactgggac cctgatggtc     3780

ttctttggaa atgtggattc ctctggcatc aagcacaaca tcttcaatcc acccatcatt     3840

gccaggtaca tcaggctgca tcctacccac tatagcatca ggtctaccct gagaatggag     3900

ctgatgggat gtgacctgaa cagctgttct atgccactgg gcatggagtc caaggctatc     3960

tctgatgccc agatcacagc ttcttcctac ttcaccaata tgtttgctac ctggtcccca     4020

agcaaggcta gactgcacct gcagggaaga tccaatgctt ggagacccca ggtgaacaat     4080

cctaaggagt ggctgcaggt ggacttccag aaaaccatga aggtcacagg ggtgaccacc     4140

cagggagtga aatctctgct gacctccatg tatgtcaagg agttcctgat cagctcttcc     4200

caggatggcc accagtggac cctgttcttt cagaatggca aggtcaaagt gttccagggg     4260

aatcaggact cttttacccc agtggtgaac tccctggatc ctccactgct gaccaggtac     4320

ctgagaatcc atcctcagag ctgggtgcac cagattgctc tgagaatgga ggtcctggga     4380

tgtgaagctc aggacctgta ttga                                            4404


<210>  12
<211>  4404
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant fVIII

<400>  12
atgcagctgg aactgtctac ctgtgtgttt ctgtgtctgc tgcctctggg gttttctgct       60

atccgccgct actatctggg agccgtggag ctgtcctggg actacaggca gagcgagctg      120

ctgagagaac tgcacgtgga taccagattc ccagctaccg ctccaggagc tctgcctctg      180

ggcccatccg tgctgtacaa gaaaaccgtc ttcgtggagt ttaccgacca gctgttcagc      240

gtggccaggc caagaccacc ttggatggga ctgctgggac caaccatcca ggctgaggtg      300

tacgataccg tggtcgtgac cctgaaaaac atggcctccc atcccgtgag cctgcacgct      360

gtcggggtgt ccttctggaa gtccagcgag ggagccgagt acgaagacca tacctcccag      420

cgcgagaaag aagacgataa ggtgctgcct ggcaaaagcc agacctatgt ctggcaggtg      480

ctgaaggaga acggaccaac cgctagcgac ccaccatgcc tgacctactc ttatctgtcc      540

cacgtcgatc tggtgaagga cctgaattcc ggactgatcg gagctctgct ggtgtgtaga      600

gagggaagcc tgaccagaga aagaacccag aacctgcatg agttcgtcct gctgttcgcc      660

gtgtttgacg aagggaagag ctggcactct gcccgcaatg actcctggac cagagctatg      720

gatccagctc ctgctagagc tcagcctgct atgcacaccg tcaacggcta cgtgaatcgg      780

tctctgccag gactgatcgg ctgccataag aaaagcgtct attggcacgt gatcggaatg      840

ggcaccagcc ccgaggtgca ttctatcttc ctggaaggcc acacctttct ggtcaggcac      900

catagacagg cctctctgga gatctcccct ctgaccttcc tgaccgctca gacctttctg      960

atggacctgg ggcagttcct gctgttttgc catatctctt cccaccatca cggaggaatg     1020

gaggctcacg tcagggtgga atcctgtgct gaggaaccac agctgagaag aaaggctgat     1080

gaggaagagg actacgacga taacctgtat gacagcgata tggacgtcgt gcgcctggac     1140

ggcgacgatg tcagcccttt catccagatc cggtctgtgg ccaagaaaca tccaaagacc     1200

tgggtccact acatcgccgc tgaagaggaa gattgggact atgcccccct ggtgctggct     1260

cctgacgata gatcctacaa aagccagtat ctgaacaatg ggccccagcg catcggacgg     1320

aagtacaaga aagtgaggtt catggcctat accgacgaga cctttaagac cagagaggct     1380

atccagcacg aatccgggat cctgggacct ctgctgtacg gcgaagtggg ggataccctg     1440

ctgatcatct tcaagaacca ggcctccagg ccatacaata tctatcccca tggcatcacc     1500

gacgtgagac cactgtacag caggagactg cccaaggggg tcaaacacct gaaggatttc     1560

cccatcctgc ctggagagat ctttaagtat aaatggaccg tcaccgtgga agacgggcct     1620

accaagtccg atccacgctg cctgacccgg tactatagct ctttcgtgaa catggagaga     1680

gacctggcta gcggactgat cggacccctg ctgatctgtt acaaagagag cgtggaccag     1740

aggggcaacc agatcatgtc tgataagaga aatgtcatcc tgttctccgt gtttgacgag     1800

aaccgcagct ggtacctgac cgagaacatc cagcggttcc tgccaaatcc agctggagtg     1860

cagctggagg acccagaatt tcaggcttcc aacatcatgc atagcatcaa tggctacgtg     1920

ttcgatagcc tgcagctgtc tgtctgcctg cacgaggtgg cctactggta tatcctgtcc     1980

atcggcgctc agaccgactt cctgtccgtg ttctttagcg ggtacacctt taagcataaa     2040

atggtgtatg aggataccct gaccctgttc cccttttctg gcgagaccgt gttcatgtcc     2100

atggaaaacc ctggcctgtg gatcctgggg tgccacaaca gcgacttcag gaatagagga     2160

atgaccgccc tgctgaaagt gtccagctgt gataagaata ccggcgatta ctatgaggac     2220

tcttacgaag atatctccgc ttatctgctg agcaagaaca atgccatcga gcccaggtct     2280

ttcgctcaga actccagacc tccaagcgct tctgctccta agccacctgt gctgagaaga     2340

catcagaggg acatctccct gcctaccttc cagccagagg aagataaaat ggactacgac     2400

gatatcttca gcaccgagac caagggggaa gattttgaca tctatggaga ggacgaaaac     2460

caggatccaa gatccttcca gaagagaacc agacactact ttatcgccgc tgtggagcag     2520

ctgtgggact atgggatgtc cgaaagccca cgggccctga ggaacagagc tcagaatgga     2580

gaggtgcccc gcttcaagaa agtcgtgttc cgggagtttg ccgacggcag ctttacccag     2640

ccatcttaca ggggggagct gaacaagcat ctggggctgc tgggacccta tatcagagcc     2700

gaggtcgaag ataacatcat ggtgaccttc aagaatcagg cttctcgccc ctactccttt     2760

tattcttccc tgatctccta ccctgacgat caggagcagg gcgccgaacc taggcacaac     2820

ttcgtgcagc caaatgagac cagaacctac ttttggaagg tgcagcatca catggctccc     2880

accgaggatg aattcgactg caaagcttgg gcctattttt ccgatgtcga cctggagaag     2940

gacgtgcata gcggcctgat cgggcctctg ctgatctgtc gcgccaacac cctgaatgct     3000

gctcacggaa gacaggtcac cgtgcaggag ttcgctctgt tctttaccat ctttgacgaa     3060

accaagagct ggtacttcac cgagaacgtg gaaaggaatt gcagagcccc ctgtcatctg     3120

cagatggagg accctaccct gaaggaaaac tacaggttcc acgccatcaa tggatatgtc     3180

atggataccc tgcccggcct ggtcatggct cagaaccagc gcatccggtg gtacctgctg     3240

tctatgggat ccaacgagaa tatccatagc atccacttct ctggccatgt cttttccgtg     3300

aggaagaaag aggaatacaa aatggccgtg tacaatctgt atcctggggt cttcgagacc     3360

gtggaaatgc tgccaagcaa agtgggaatc tggagaatcg agtgcctgat cggcgaacac     3420

ctgcaggccg ggatgagcac caccttcctg gtgtactcta agaaatgtca gaccccactg     3480

gggatggcct ccggacatat ccgcgacttc cagatcaccg ctagcggaca gtacggacag     3540

tgggctccaa agctggctag actgcactat tctggctcca tcaacgcctg gtctaccaaa     3600

gagccattct cctggatcaa ggtggacctg ctggccccca tgatcatcca cggaatcaaa     3660

acccagggcg ctaggcagaa gttcagctct ctgtacatct cccagtttat catcatgtat     3720

agcctggacg ggaagaaatg gcagacctac agaggcaatt ccaccgggac cctgatggtc     3780

ttctttggaa acgtggattc cagcggcatc aagcacaaca tcttcaatcc acccatcatc     3840

gcccgctaca tccggctgca tcctacccac tatagcatca ggtctaccct gagaatggag     3900

ctgatgggat gcgacctgaa cagctgttct atgccactgg gcatggagtc caaggctatc     3960

agcgatgccc agatcaccgc ttcttcctac ttcaccaata tgtttgctac ctggtcccca     4020

agcaaggcta gactgcacct gcagggaaga tccaacgctt ggagacccca ggtgaacaat     4080

cctaaggagt ggctgcaggt cgacttccag aaaaccatga aggtcaccgg ggtgaccacc     4140

cagggagtga aatctctgct gacctccatg tacgtcaagg agttcctgat cagctcttcc     4200

caggacggcc accagtggac cctgttcttt cagaacggca aggtcaaagt gttccagggg     4260

aatcaggact cttttacccc cgtcgtgaac tccctggatc ctccactgct gaccaggtac     4320

ctgagaatcc atcctcagag ctgggtgcac cagatcgctc tgagaatgga ggtcctggga     4380

tgcgaagctc aggacctgta ttga                                            4404


<210>  13
<211>  391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  13

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              


Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  


Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Val His Leu Phe Asn Ile 
65                  70                  75                  80  


Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      


Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         


His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             


Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 


Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 


Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     


Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         


Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             


Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 


Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 


Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     


Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         


Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             


Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 


Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 


Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     


Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         


Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             


Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Ser Phe Ile Gln Ile Arg 
385                 390     


<210>  14
<211>  391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  14

Met Gln Leu Glu Leu Ser Thr Cys Val Phe Leu Cys Leu Leu Pro Leu 
1               5                   10                  15      


Gly Phe Ser Ala Ile Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Arg Gln Ser Glu Leu Leu Arg Glu Leu His Val Asp Thr 
        35                  40                  45              


Arg Phe Pro Ala Thr Ala Pro Gly Ala Leu Pro Leu Gly Pro Ser Val 
    50                  55                  60                  


Leu Tyr Lys Lys Thr Val Phe Val Glu Phe Thr Asp Gln Leu Phe Ser 
65                  70                  75                  80  


Val Ala Arg Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile 
                85                  90                  95      


Gln Ala Glu Val Tyr Asp Thr Val Val Val Thr Leu Lys Asn Met Ala 
            100                 105                 110         


Ser His Pro Val Ser Leu His Ala Val Gly Val Ser Phe Trp Lys Ser 
        115                 120                 125             


Ser Glu Gly Ala Glu Tyr Glu Asp His Thr Ser Gln Arg Glu Lys Glu 
    130                 135                 140                 


Asp Asp Lys Val Leu Pro Gly Lys Ser Gln Thr Tyr Val Trp Gln Val 
145                 150                 155                 160 


Leu Lys Glu Asn Gly Pro Thr Ala Ser Asp Pro Pro Cys Leu Thr Tyr 
                165                 170                 175     


Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu 
            180                 185                 190         


Ile Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Thr Arg Glu Arg 
        195                 200                 205             


Thr Gln Asn Leu His Glu Phe Val Leu Leu Phe Ala Val Phe Asp Glu 
    210                 215                 220                 


Gly Lys Ser Trp His Ser Ala Arg Asn Asp Ser Trp Thr Arg Ala Met 
225                 230                 235                 240 


Asp Pro Ala Pro Ala Arg Ala Gln Pro Ala Met His Thr Val Asn Gly 
                245                 250                 255     


Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Lys Lys Ser 
            260                 265                 270         


Val Tyr Trp His Val Ile Gly Met Gly Thr Ser Pro Glu Val His Ser 
        275                 280                 285             


Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg His His Arg Gln Ala 
    290                 295                 300                 


Ser Leu Glu Ile Ser Pro Leu Thr Phe Leu Thr Ala Gln Thr Phe Leu 
305                 310                 315                 320 


Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His His 
                325                 330                 335     


His Gly Gly Met Glu Ala His Val Arg Val Glu Ser Cys Ala Glu Glu 
            340                 345                 350         


Pro Gln Leu Arg Arg Lys Ala Asp Glu Glu Glu Asp Tyr Asp Asp Asn 
        355                 360                 365             


Leu Tyr Asp Ser Asp Met Asp Val Val Arg Leu Asp Gly Asp Asp Val 
    370                 375                 380                 


Ser Pro Phe Ile Gln Ile Arg 
385                 390     


<210>  15
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  15

Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr 
1               5                   10                  15      


Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr 
            20                  25                  30          


Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg 
        35                  40                  45              


His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser 
    50                  55                  60                  


Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro 
65                  70                  75                  80  


Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr 
                85                  90                  95      


Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly 
            100                 105                 110         


Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg 
        115                 120                 125             


Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr 
    130                 135                 140                 


Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys 
145                 150                 155                 160 


Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met Ala 
                165                 170                 175     


Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp 
            180                 185                 190         


Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro Leu Leu 
        195                 200                 205             


Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln Val Thr 
    210                 215                 220                 


Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr Lys Ser 
225                 230                 235                 240 


Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn Cys Arg Ala Pro Cys Asn 
                245                 250                 255     


Ile Gln Met Glu Asp Pro Thr Phe Lys Glu Asn Tyr Arg Phe His Ala 
            260                 265                 270         


Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro Gly Leu Val Met Ala Gln 
        275                 280                 285             


Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser Asn Glu Asn 
    290                 295                 300                 


Ile His Ser Ile His Phe Ser Gly His Val Phe Thr Val Arg Lys Lys 
305                 310                 315                 320 


Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu Tyr Pro Gly Val Phe Glu 
                325                 330                 335     


Thr Val Glu Met Leu Pro Ser Lys Ala Gly Ile Trp Arg Val Glu Cys 
            340                 345                 350         


Leu Ile Gly Glu His Leu His Ala Gly Met Ser Thr Leu Phe Leu Val 
        355                 360                 365             


Tyr Ser Asn 
    370     


<210>  16
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  16

Asp Ile Ser Leu Pro Thr Phe Gln Pro Glu Glu Asp Lys Met Asp Tyr 
1               5                   10                  15      


Asp Asp Ile Phe Ser Thr Glu Thr Lys Gly Glu Asp Phe Asp Ile Tyr 
            20                  25                  30          


Gly Glu Asp Glu Asn Gln Asp Pro Arg Ser Phe Gln Lys Arg Thr Arg 
        35                  40                  45              


His Tyr Phe Ile Ala Ala Val Glu Gln Leu Trp Asp Tyr Gly Met Ser 
    50                  55                  60                  


Glu Ser Pro Arg Ala Leu Arg Asn Arg Ala Gln Asn Gly Glu Val Pro 
65                  70                  75                  80  


Arg Phe Lys Lys Val Val Phe Arg Glu Phe Ala Asp Gly Ser Phe Thr 
                85                  90                  95      


Gln Pro Ser Tyr Arg Gly Glu Leu Asn Lys His Leu Gly Leu Leu Gly 
            100                 105                 110         


Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Lys 
        115                 120                 125             


Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr 
    130                 135                 140                 


Pro Asp Asp Gln Glu Gln Gly Ala Glu Pro Arg His Asn Phe Val Gln 
145                 150                 155                 160 


Pro Asn Glu Thr Arg Thr Tyr Phe Trp Lys Val Gln His His Met Ala 
                165                 170                 175     


Pro Thr Glu Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp 
            180                 185                 190         


Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro Leu Leu 
        195                 200                 205             


Ile Cys Arg Ala Asn Thr Leu Asn Ala Ala His Gly Arg Gln Val Thr 
    210                 215                 220                 


Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr Lys Ser 
225                 230                 235                 240 


Trp Tyr Phe Thr Glu Asn Val Glu Arg Asn Cys Arg Ala Pro Cys His 
                245                 250                 255     


Leu Gln Met Glu Asp Pro Thr Leu Lys Glu Asn Tyr Arg Phe His Ala 
            260                 265                 270         


Ile Asn Gly Tyr Val Met Asp Thr Leu Pro Gly Leu Val Met Ala Gln 
        275                 280                 285             


Asn Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser Asn Glu Asn 
    290                 295                 300                 


Ile His Ser Ile His Phe Ser Gly His Val Phe Ser Val Arg Lys Lys 
305                 310                 315                 320 


Glu Glu Tyr Lys Met Ala Val Tyr Asn Leu Tyr Pro Gly Val Phe Glu 
                325                 330                 335     


Thr Val Glu Met Leu Pro Ser Lys Val Gly Ile Trp Arg Ile Glu Cys 
            340                 345                 350         


Leu Ile Gly Glu His Leu Gln Ala Gly Met Ser Thr Thr Phe Leu Val 
        355                 360                 365             


Tyr Ser Lys 
    370     


<210>  17
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant fIX

<400>  17

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Ala Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460     


<210>  18
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant fIX

<400>  18

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Ala Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Leu 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460     


<210>  19
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant fIX

<400>  19

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Leu 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460     


<210>  20
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  20
tataaaaggc cagcagcagc ctgaccacat ctcatcctc                              39


<210>  21
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  21
gttaattttt gtggcccttg cgatgtttgc tctggtta                               38


<210>  22
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant peptide linker

<400>  22

Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln Arg 
1               5                   10                  


<210>  23
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant peptide linker

<400>  23

Ser Phe Ala Gln Asn Ser Arg Pro Pro Ser Ala Ser Ala Pro Lys Pro 
1               5                   10                  15      


Pro Val Leu Arg Arg His Gln Arg 
            20                  


<210>  24
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  24

Arg His Gln Arg 
1               


<210>  25
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  25
gttaat                                                                   6


<210>  26
<211>  5
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  26
tataa                                                                    5


<210>  27
<211>  5
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  27
gttaa                                                                    5


<210>  28
<211>  4
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  28
gtta                                                                     4


<210>  29
<211>  3
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  29
gtt                                                                      3


<210>  30
<211>  5
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  30
ttaat                                                                    5


<210>  31
<211>  4
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  31
ttaa                                                                     4


<210>  32
<211>  3
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  32
tta                                                                      3


<210>  33
<211>  3
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  33
aat                                                                      3


<210>  34
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  34
gttaattttt gtggcccttg cgatgtttgc tctggttaat aatctcagga caaaca           56


<210>  35
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  35
ttaatttttg tggcccttgc gatgtttgct ctggttaata atctcaggac aaaca            55


<210>  36
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  36
taatttttgt ggcccttgcg atgtttgctc tggttaataa tctcaggaca aaca             54


<210>  37
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  37
aatttttgtg gcccttgcga tgtttgctct ggttaataat ctcaggacaa aca              53


<210>  38
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  38
atttttgtgg cccttgcgat gtttgctctg gttaataatc tcaggacaaa ca               52


<210>  39
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  39
tttttgtggc ccttgcgatg tttgctctgg ttaataatct caggacaaac a                51


<210>  40
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  40
ttttgtggcc cttgcgatgt ttgctctggt taataatctc aggacaaaca                  50


<210>  41
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  41
tttgtggccc ttgcgatgtt tgctctggtt aataatctca ggacaaaca                   49


<210>  42
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  42
ttgtggccct tgcgatgttt gctctggtta ataatctcag gacaaaca                    48


<210>  43
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  43
ataatctcag gacaaaca                                                     18


<210>  44
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  44
tgtggccctt gcgatgtttg ctctggttaa taatctcagg acaaaca                     47


<210>  45
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  45
gtggcccttg cgatgtttgc tctggttaat aatctcagga caaaca                      46


<210>  46
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  46
tggcccttgc gatgtttgct ctggttaata atctcaggac aaaca                       45


<210>  47
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  47
gcccttgcga tgtttgctct ggttaataat ctcaggacaa aca                         43


<210>  48
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  48
cccttgcgat gtttgctctg gttaataatc tcaggacaaa ca                          42


<210>  49
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  49
ccttgcgatg tttgctctgg ttaataatct caggacaaac a                           41


<210>  50
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  50
cttgcgatgt ttgctctggt taataatctc aggacaaaca                             40


<210>  51
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  51
gttaattttt gtggcccttg cgatgtttgc tctggttaat aatctcagga caaac            55


<210>  52
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  52
gttaattttt gtggcccttg cgatgtttgc tctggttaat aatctcagga caaa             54


<210>  53
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  53
gttaattttt gtggcccttg cgatgtttgc tctggttaat aatctcagga caa              53


<210>  54
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  54
gttaattttt gtggcccttg cgatgtttgc tctggttaat aatctcagga caa              53


<210>  55
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  55
gttaattttt gtggcccttg cgatgtttgc tctggttaat aatctcagga ca               52


<210>  56
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  56
gttaattttt gtggcccttg cgatgtttgc tctggttaat aatctcagga c                51


<210>  57
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  57
gttaattttt gtggcccttg cgatgtttgc tctggttaat aatctcagga                  50


<210>  58
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  58
gttaattttt gtggcccttg cgatgtttgc tctggttaat aatctcagg                   49


<210>  59
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  59
gttaattttt gtggcccttg cgatgtttgc tctggttaat aatctcag                    48


<210>  60
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  60
gttaattttt gtggcccttg cgatgtttgc tctggttaat aatctca                     47


<210>  61
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  61
gttaattttt gtggcccttg cgatgtttgc tctggttaat aatctc                      46


<210>  62
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  62
gttaattttt gtggcccttg cgatgtttgc tctggttaat aatct                       45


<210>  63
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  63
gttaattttt gtggcccttg cgatgtttgc tctggttaat aatc                        44


<210>  64
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  64
gttaattttt gtggcccttg cgatgtttgc tctggttaat aat                         43


<210>  65
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  65
gttaattttt gtggcccttg cgatgtttgc tctggttaat aa                          42


<210>  66
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  66
gttaattttt gtggcccttg cgatgtttgc tctggttaat aatctcagga caaac            55


<210>  67
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  67
ttaatttttg tggcccttgc gatgtttgct ctggttaata atctcaggac aaa              53


<210>  68
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  68
taatttttgt ggcccttgcg atgtttgctc tggttaataa tctcaggaca a                51


<210>  69
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  69
aatttttgtg gcccttgcga tgtttgctct ggttaataat ctcaggaca                   49


<210>  70
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  70
atttttgtgg cccttgcgat gtttgctctg gttaataatc tcaggac                     47


<210>  71
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  71
tttttgtggc ccttgcgatg tttgctctgg ttaataatct cagga                       45


<210>  72
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  72
ttttgtggcc cttgcgatgt ttgctctggt taataatctc agg                         43


<210>  73
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  73
tttgtggccc ttgcgatgtt tgctctggtt aataatctca g                           41


<210>  74
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  74
ttgtggccct tgcgatgttt gctctggtta ataatctca                              39


<210>  75
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  75
tgtggccctt gcgatgtttg ctctggttaa taatctc                                37


<210>  76
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  76
gtggcccttg cgatgtttgc tctggttaat aatct                                  35


<210>  77
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  77
tggcccttgc gatgtttgct ctggttaata atc                                    33


<210>  78
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  78
gcccttgcga tgtttgctct ggttaataat                                        30


<210>  79
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  79
cccttgcgat gtttgctctg gttaataa                                          28


<210>  80
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  80
ccttgcgatg tttgctctgg ttaata                                            26


<210>  81
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  81
cttgcgatgt ttgctctggt taat                                              24


<210>  82
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  82
ttaatttttg tggcccttgc gatgtttgct ctggttaata atctcaggac aaac             54


<210>  83
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  83
taatttttgt ggcccttgcg atgtttgctc tggttaataa tctcaggaca aa               52


<210>  84
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  84
aatttttgtg gcccttgcga tgtttgctct ggttaataat ctcaggacaa                  50


<210>  85
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  85
atttttgtgg cccttgcgat gtttgctctg gttaataatc tcaggacaa                   49


<210>  86
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  86
tttttgtggc ccttgcgatg tttgctctgg ttaataatct caggaca                     47


<210>  87
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  87
ttttgtggcc cttgcgatgt ttgctctggt taataatctc aggac                       45


<210>  88
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  88
tttgtggccc ttgcgatgtt tgctctggtt aataatctca gga                         43


<210>  89
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  89
ttgtggccct tgcgatgttt gctctggtta ataatctcag g                           41


<210>  90
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  90
tgtggccctt gcgatgtttg ctctggttaa taatctcag                              39


<210>  91
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  91
tggcccttgc gatgtttgct ctggttaata atctca                                 36


<210>  92
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  92
ggcccttgcg atgtttgctc tggttaataa tctc                                   34


<210>  93
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  93
gcccttgcga tgtttgctct ggttaataat ct                                     32


<210>  94
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  94
cccttgcgat gtttgctctg gttaataatc                                        30


<210>  95
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  95
ccttgcgatg tttgctctgg ttaataat                                          28


<210>  96
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  96
cttgcgatgt ttgctctggt taataa                                            26


<210>  97
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  97
cggaggagca aacaggg                                                      17


<210>  98
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  98
cggaggagca aacaggggct aagtccac                                          28


<210>  99
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  99
ggctgctggt gaatattaac caaggtc                                           27


<210>  100
<211>  71
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  100
ggggaggctg ctggtgaata ttaaccaagg tcaccccagt tatcggagga gcaaacaggg       60

gctaagtcca c                                                            71


<210>  101
<211>  71
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  101
ggggaggctg ctggtgaata ttaaccaagg tcaccccagt tatcggagga gcaaacaggg       60

actaagtcca c                                                            71


<210>  102
<211>  220
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  102
ggggaggctg ctggtgaata ttaaccaagg tcaccccagt tatcggagga gcaaacaggg       60

gctaagtcca ctaggttaat cattaagtcg ttaatttttg tggcccttgc gatgtttgct      120

ctggttaata atctcaggac aaacagaggt taataatttt ccagatctct ctgagcaata      180

gtataaaagg ccagcagcag cctgaccaca tctcatcctc                            220


<210>  103
<211>  171
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  103
cggaggagca aacaggggct aagtcgttaa tcattaagtc gttaattttt gtggcccttg       60

cgatgtttgc tctggttaat aatctcagga caaacagagg ttaataattt tccagatctc      120

tctgagcaat agtataaaag gccagcagca gcctgaccac atctcatcct c               171


<210>  104
<211>  173
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  104
ggctgctggt gaatattaac caaggtcgtt aatcattaag tcgttaattt ttgtggccct       60

tgcgatgttt gctctggtta ataatctcag gacaaacaga ggttaataat tttccagatc      120

tctctgagca atagtataaa aggccagcag cagcctgacc acatctcatc ctc             173


<210>  105
<211>  146
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  105
ggggaggctg ctggtgaata ttaaccaagg tcaccccagt tatcggagga gcaaacaggg       60

gctaagtcca cgaggttaat aattttccag atctctctga gcaatagtat aaaaggccag      120

cagcagcctg accacatctc atcctc                                           146


<210>  106
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  106
ggctgctggt gaatattaac caaggtcatc ggaggagcaa acagggacta agtcgaggtt       60

aataattttc cagatctctc tgagcaatag tataaaaggc cagcagcagc ctgaccacat      120

ctcatcctc                                                              129


<210>  107
<211>  142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  107
ggctgctggt gaatattaac caaggtcccc ttgctggtta ataatctcag ttaatttgtt       60

tgcacaaaca cggaggagca aacaggggag gttaataatt ttctataaaa ggccagcagc      120

agcctgacca catctcatcc tc                                               142


<210>  108
<211>  146
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  108
ggggaggctg ctggtgaata ttaaccaagg tcaccccagt tatcggagga gcaaacaggg       60

actaagtcca cgaggttaat aattttccag atctctctga gcaatagtat aaaaggccag      120

cagcagcctg accacatctc atcctc                                           146


<210>  109
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  109
tcatcctc                                                                 8


<210>  110
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  110
ggccagcagc agcctgacca catc                                              24


<210>  111
<211>  71
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  111
ggggaggctg ctggtgaata ttaaccaagg tcaccccagt tatcggagga gcaaacaggg       60

gctaagtcca c                                                            71


<210>  112
<211>  255
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  112
gttaatcatt aagtcgttaa tcattaactt aggtcaaagg tcagacaatg ttgactctcg       60

ttaatgatta accggaattg ttgacttgag gttaataatt ttccagatct ctctgagcaa      120

tagtataaaa ggccagcagc agcctgacca catctcatcc tcctctaagg taaatataaa      180

atttttaagt gtataatgtg ttaaactact gattctaatt gtttgtgtat tttagattcc      240

aacctatgga actga                                                       255


<210>  113
<211>  94
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  113
gttaattttt aaaaagcagt caaaagtcca agtggccctt gcgagcattt actctctctg       60

tttgctctgg ttaataatct caggagcaca aaca                                   94


<210>  114
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  114
gaggttaata attttccaga tctctctgag caatagtata aaa                         43


<210>  115
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  115
agtcatatgt ttgctcactg aaggttacta gttaacaggc atcccttaaa cagga            55


<210>  116
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  116
gttaatcatt aacttaaaaa gcagtcaaaa gtccaaaggt caaaggtcag agcatttact       60

ctctccaatg ttgactctcg ttaatgatta aggagcaatt gttgactt                   108


<210>  117
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  117
gttaatcatt aacttaggtc aaaggtcaga caatgttgac tctcgttaat gattaaccgg       60

aattgttgac tt                                                           72


<210>  118
<211>  151
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  118
gttaatcatt aacttaaaaa gcagtcaaaa gtccaaaggt caaaggtcag agcatttact       60

ctctccaatg ttgactctcg ttaatgatta aggagcaatt gttgacttga ggttaataat      120

tttccagatc tctctgagca atagtataaa a                                     151


<210>  119
<211>  115
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  119
gttaatcatt aacttaggtc aaaggtcaga caatgttgac tctcgttaat gattaaccgg       60

aattgttgac ttgaggttaa taattttcca gatctctctg agcaatagta taaaa           115


<210>  120
<211>  152
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  120
gttaatcatt aagtcgttaa tttttaaaaa gcagtcaaaa gtccaagtgg cccttgcgag       60

catttactct ctctgtttgc tctggttaat aatctcagga gcacaaacag aggttaataa      120

ttttccagat ctctctgagc aatagtataa aa                                    152


<210>  121
<211>  150
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  121
tgggcggagt gtcgttaatt tttaaaaagc agtcaaaagt ccaagtggcc cttgcgagca       60

tttactctct ctgtttgctc tggttaataa tctcaggagc acaaacagag gttaataatt      120

ttccagatct ctctgagcaa tagtataaaa                                       150


<210>  122
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  122
cccttgctgg ttaataatct cagttaattt gtttgcacaa aca                         43


<210>  123
<211>  1467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant fVIII

<400>  123

Met Gln Leu Glu Leu Ser Thr Cys Val Phe Leu Cys Leu Leu Pro Leu 
1               5                   10                  15      


Gly Phe Ser Ala Ile Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Arg Gln Ser Glu Leu Leu Arg Glu Leu His Val Asp Thr 
        35                  40                  45              


Arg Phe Pro Ala Thr Ala Pro Gly Ala Leu Pro Leu Gly Pro Ser Val 
    50                  55                  60                  


Leu Tyr Lys Lys Thr Val Phe Val Glu Phe Thr Asp Gln Leu Phe Ser 
65                  70                  75                  80  


Val Ala Arg Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile 
                85                  90                  95      


Gln Ala Glu Val Tyr Asp Thr Val Val Val Thr Leu Lys Asn Met Ala 
            100                 105                 110         


Ser His Pro Val Ser Leu His Ala Val Gly Val Ser Phe Trp Lys Ser 
        115                 120                 125             


Ser Glu Gly Ala Glu Tyr Glu Asp His Thr Ser Gln Arg Glu Lys Glu 
    130                 135                 140                 


Asp Asp Lys Val Leu Pro Gly Lys Ser Gln Thr Tyr Val Trp Gln Val 
145                 150                 155                 160 


Leu Lys Glu Asn Gly Pro Thr Ala Ser Asp Pro Pro Cys Leu Thr Tyr 
                165                 170                 175     


Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu 
            180                 185                 190         


Ile Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Thr Arg Glu Arg 
        195                 200                 205             


Thr Gln Asn Leu His Glu Phe Val Leu Leu Phe Ala Val Phe Asp Glu 
    210                 215                 220                 


Gly Lys Ser Trp His Ser Ala Arg Asn Asp Ser Trp Thr Arg Ala Met 
225                 230                 235                 240 


Asp Pro Ala Pro Ala Arg Ala Gln Pro Ala Met His Thr Val Asn Gly 
                245                 250                 255     


Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Lys Lys Ser 
            260                 265                 270         


Val Tyr Trp His Val Ile Gly Met Gly Thr Ser Pro Glu Val His Ser 
        275                 280                 285             


Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg His His Arg Gln Ala 
    290                 295                 300                 


Ser Leu Glu Ile Ser Pro Leu Thr Phe Leu Thr Ala Gln Thr Phe Leu 
305                 310                 315                 320 


Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His His 
                325                 330                 335     


His Gly Gly Met Glu Ala His Val Arg Val Glu Ser Cys Ala Glu Glu 
            340                 345                 350         


Pro Gln Leu Arg Arg Lys Ala Asp Glu Glu Glu Asp Tyr Asp Asp Asn 
        355                 360                 365             


Leu Tyr Asp Ser Asp Met Asp Val Val Arg Leu Asp Gly Asp Asp Val 
    370                 375                 380                 


Ser Pro Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         


Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         


Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         


Asn Asn Ala Ile Glu Pro Arg Ser Phe Ala Gln Asn Ser Arg Pro Pro 
        755                 760                 765             


Ser Ala Ser Ala Pro Lys Pro Pro Val Leu Arg Arg His Gln Arg Asp 
    770                 775                 780                 


Ile Ser Leu Pro Thr Phe Gln Pro Glu Glu Asp Lys Met Asp Tyr Asp 
785                 790                 795                 800 


Asp Ile Phe Ser Thr Glu Thr Lys Gly Glu Asp Phe Asp Ile Tyr Gly 
                805                 810                 815     


Glu Asp Glu Asn Gln Asp Pro Arg Ser Phe Gln Lys Arg Thr Arg His 
            820                 825                 830         


Tyr Phe Ile Ala Ala Val Glu Gln Leu Trp Asp Tyr Gly Met Ser Glu 
        835                 840                 845             


Ser Pro Arg Ala Leu Arg Asn Arg Ala Gln Asn Gly Glu Val Pro Arg 
    850                 855                 860                 


Phe Lys Lys Val Val Phe Arg Glu Phe Ala Asp Gly Ser Phe Thr Gln 
865                 870                 875                 880 


Pro Ser Tyr Arg Gly Glu Leu Asn Lys His Leu Gly Leu Leu Gly Pro 
                885                 890                 895     


Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Lys Asn 
            900                 905                 910         


Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Pro 
        915                 920                 925             


Asp Asp Gln Glu Gln Gly Ala Glu Pro Arg His Asn Phe Val Gln Pro 
    930                 935                 940                 


Asn Glu Thr Arg Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro 
945                 950                 955                 960 


Thr Glu Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val 
                965                 970                 975     


Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro Leu Leu Ile 
            980                 985                 990         


Cys Arg Ala Asn Thr Leu Asn Ala  Ala His Gly Arg Gln  Val Thr Val 
        995                 1000                 1005             


Gln Glu  Phe Ala Leu Phe Phe  Thr Ile Phe Asp Glu  Thr Lys Ser 
    1010                 1015                 1020             


Trp Tyr  Phe Thr Glu Asn Val  Glu Arg Asn Cys Arg  Ala Pro Cys 
    1025                 1030                 1035             


His Leu  Gln Met Glu Asp Pro  Thr Leu Lys Glu Asn  Tyr Arg Phe 
    1040                 1045                 1050             


His Ala  Ile Asn Gly Tyr Val  Met Asp Thr Leu Pro  Gly Leu Val 
    1055                 1060                 1065             


Met Ala  Gln Asn Gln Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly 
    1070                 1075                 1080             


Ser Asn  Glu Asn Ile His Ser  Ile His Phe Ser Gly  His Val Phe 
    1085                 1090                 1095             


Ser Val  Arg Lys Lys Glu Glu  Tyr Lys Met Ala Val  Tyr Asn Leu 
    1100                 1105                 1110             


Tyr Pro  Gly Val Phe Glu Thr  Val Glu Met Leu Pro  Ser Lys Val 
    1115                 1120                 1125             


Gly Ile  Trp Arg Ile Glu Cys  Leu Ile Gly Glu His  Leu Gln Ala 
    1130                 1135                 1140             


Gly Met  Ser Thr Thr Phe Leu  Val Tyr Ser Lys Lys  Cys Gln Thr 
    1145                 1150                 1155             


Pro Leu  Gly Met Ala Ser Gly  His Ile Arg Asp Phe  Gln Ile Thr 
    1160                 1165                 1170             


Ala Ser  Gly Gln Tyr Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu 
    1175                 1180                 1185             


His Tyr  Ser Gly Ser Ile Asn  Ala Trp Ser Thr Lys  Glu Pro Phe 
    1190                 1195                 1200             


Ser Trp  Ile Lys Val Asp Leu  Leu Ala Pro Met Ile  Ile His Gly 
    1205                 1210                 1215             


Ile Lys  Thr Gln Gly Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile 
    1220                 1225                 1230             


Ser Gln  Phe Ile Ile Met Tyr  Ser Leu Asp Gly Lys  Lys Trp Gln 
    1235                 1240                 1245             


Thr Tyr  Arg Gly Asn Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly 
    1250                 1255                 1260             


Asn Val  Asp Ser Ser Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro 
    1265                 1270                 1275             


Ile Ile  Ala Arg Tyr Ile Arg  Leu His Pro Thr His  Tyr Ser Ile 
    1280                 1285                 1290             


Arg Ser  Thr Leu Arg Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser 
    1295                 1300                 1305             


Cys Ser  Met Pro Leu Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala 
    1310                 1315                 1320             


Gln Ile  Thr Ala Ser Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp 
    1325                 1330                 1335             


Ser Pro  Ser Lys Ala Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala 
    1340                 1345                 1350             


Trp Arg  Pro Gln Val Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp 
    1355                 1360                 1365             


Phe Gln  Lys Thr Met Lys Val  Thr Gly Val Thr Thr  Gln Gly Val 
    1370                 1375                 1380             


Lys Ser  Leu Leu Thr Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser 
    1385                 1390                 1395             


Ser Ser  Gln Asp Gly His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly 
    1400                 1405                 1410             


Lys Val  Lys Val Phe Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val 
    1415                 1420                 1425             


Val Asn  Ser Leu Asp Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile 
    1430                 1435                 1440             


His Pro  Gln Ser Trp Val His  Gln Ile Ala Leu Arg  Met Glu Val 
    1445                 1450                 1455             


Leu Gly  Cys Glu Ala Gln Asp  Leu Tyr 
    1460                 1465         


<210>  124
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  124
atgcagaggg tcaatatgat catggctgaa tctcctgggc tgatcaccat ttgcctgctg       60

ggatacctgc tgtctgctga gtgtacagtg ttcctggacc atgagaatgc caataagatc      120

ctgaacaggc ccaaaagata caattctgga aagctggagg aatttgtgca gggcaacctg      180

gagagggaat gcatggagga aaagtgtagc tttgaggaag ctagggaggt gtttgaaaac      240

acagagagga ccacagaatt ctggaagcag tatgtggatg gagatcagtg tgagtccaac      300

ccctgtctga atggagggtc ttgcaaagat gatatcaact cctatgagtg ctggtgtcct      360

tttggatttg aaggcaaaaa ttgtgagctg gatgtgacct gtaacatcaa gaatggcagg      420

tgtgagcagt tctgtaaaaa ctctgctgat aataaggtgg tctgcagctg tacagaaggc      480

tataggctgg ctgagaacca gaagagctgt gaaccagctg tgcccttccc ttgtgggagg      540

gtgtctgtca gccagacctc taagctgacc agagctgaga ctgtgttccc agatgtggat      600

tatgtcaact ccacagaggc tgaaaccatc ctggacaaca tcacccagtc tacccagtcc      660

ttcaatgact ttaccagagt ggtgggagga gaggatgcca aaccaggcca gttcccctgg      720

caggtggtcc tgaatgggaa ggtggatgct ttttgtgggg gatccattgt gaatgagaaa      780

tggattgtca cagctgctca ctgtgtggag acaggggtca agatcactgt ggtggctgga      840

gagcacaaca ttgaggaaac agaacatact gagcagaaga ggaatgtgat cagaatcatc      900

cctcaccata actacaatgc tgctatcaac aaatataatc atgacattgc cctgctggaa      960

ctggatgagc ctctggtgct gaacagctat gtcaccccaa tctgcattgc tgacaaagag     1020

tataccaata tcttcctgaa gtttggatct ggatatgtgt ctggatgggg aagggtcttc     1080

cacaagggca ggtctgccct ggtgctgcag tatctgaggg tgcctctggt ggacagagct     1140

acctgcctgc tgtctaccaa gttcaccatc tacaacaata tgttctgtgc tggatttcat     1200

gagggaggca gggactcctg tcagggggat tctggaggcc cacatgtgac agaggtggaa     1260

ggcaccagct tcctgactgg catcatctct tggggggagg aatgtgctat gaaggggaaa     1320

tatggaatct acaccaaagt gagcaggtat gtgaactgga tcaaagagaa gaccaaactg     1380

acctga                                                                1386


<210>  125
<211>  4404
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  125
atgcagctgg agctctcaac ctgtgtgttc ctctgcctgc tccccctggg attttcagct       60

atcaggagat actatctggg agcagtggaa ctgtcctggg actacaggca gtcagagctg      120

ctcagagaac tgcatgtgga tactaggttc cctgcaacag ctcctggagc actgccactg      180

ggaccttcag tgctgtacaa gaaaactgtc tttgtggagt ttacagacca gctgttcagt      240

gtggccaggc ccaggccccc ctggatgggg ctgctgggac ccaccatcca ggctgaagtg      300

tatgatactg tggtggtgac cctgaaaaac atggcctctc atccagtcag cctgcatgct      360

gtgggagtga gcttctggaa gagcagtgag ggagctgagt atgaagacca tacctcacag      420

agggagaaag aagatgataa ggtgctgcca ggaaaaagcc agacctatgt gtggcaggtg      480

ctgaaggaga atggccctac agcttcagat cctccctgcc tcacatactc ttatctgagc      540

catgtggatc tggtgaagga cctcaatagt ggcctgattg gggcactgct ggtgtgcaga      600

gaggggtccc tcacaaggga aagaactcag aacctgcatg agtttgtcct gctctttgct      660

gtgtttgatg agggaaagtc ctggcactca gcaaggaatg acagctggac cagggctatg      720

gacccagcac cagccagagc tcagccagct atgcacactg tcaatggcta tgtgaatagg      780

tccctgcctg gactcattgg ctgccataag aaatcagtct attggcatgt gattggaatg      840

ggcaccagcc cagaggtgca ttccatcttc ctggaaggcc acacatttct ggtcaggcac      900

catagacagg ccagcctgga gatcagccca ctgactttcc tcacagcaca gacatttctg      960

atggacctgg ggcagttcct gctcttttgc catatctcaa gtcaccatca tggagggatg     1020

gaggctcatg tcagggtgga aagctgtgca gaggaacctc agctgaggag gaaggcagat     1080

gaggaagagg actatgatga taacctgtat gactcagata tggatgtggt gaggctggat     1140

ggagatgatg tcagcccatt catccagatc aggtcagtgg ctaagaaaca ccctaagacc     1200

tgggtccact acattgcagc tgaagaggaa gattgggact atgcacccct ggtgctggcc     1260

ccagatgata gaagttacaa atctcagtat ctgaacaatg ggccccagag gattggaagg     1320

aagtacaaga aagtgaggtt catggcttat actgatgaga cctttaagac aagagaggca     1380

atccagcatg aaagtggcat cctgggacca ctgctctatg gagaagtggg ggataccctg     1440

ctcatcatct tcaagaacca ggcctcaagg ccttacaata tctatcccca tggcatcaca     1500

gatgtgaggc ctctctacag caggagactg cccaagggag tcaaacacct caaggatttc     1560

cccatcctgc caggggaaat cttcaagtat aaatggacag tcactgtgga agatgggcca     1620

actaagtcag atcctaggtg cctgaccagg tactattcta gctttgtgaa catggagagg     1680

gacctggctt caggactgat tggacctctg ctcatctgct acaaagaatc agtggaccag     1740

aggggcaacc agatcatgag tgataagaga aatgtcatcc tgttctcagt gtttgatgag     1800

aataggagtt ggtatctgac agaaaacatc cagaggttcc tgcctaatcc tgcaggagtg     1860

cagctggagg acccagaatt tcaggcttca aacatcatgc atagtatcaa tggctatgtg     1920

tttgatagtc tgcagctctc tgtctgcctg catgaggtgg cctactggta tatcctcagc     1980

attggagctc agactgactt cctgagtgtg ttcttttcag gctacacatt caagcataag     2040

atggtctatg aagataccct gacactcttc cccttttctg gggagactgt gtttatgagc     2100

atggaaaacc caggcctgtg gattctgggg tgccacaaca gtgacttcag gaatagaggg     2160

atgactgctc tgctcaaagt gtcctcatgt gataagaata ctggagatta ctatgaggac     2220

tcttatgaag atatcagtgc atatctgctc tccaaaaaca atgccattga gcccaggtca     2280

tttgctcaga acagtagacc accttctgca agtgcaccaa agcctccagt gctgaggaga     2340

caccagaggg acatcagcct gccaaccttc cagcctgagg aagataaaat ggactatgat     2400

gatatcttct ccactgagac caagggggaa gattttgaca tctatggaga ggatgaaaac     2460

caggacccca ggtccttcca gaagaggacc agacactact ttattgcagc tgtggagcag     2520

ctgtgggact atggcatgtc tgaatcacct agagctctga ggaacagagc acagaatggg     2580

gaggtgccca ggttcaagaa agtggtgttc agagaatttg cagatggctc ttttacccag     2640

cctagctaca ggggggagct caacaagcat ctggggctgc tgggacccta tatcagagca     2700

gaggtggaag ataacatcat ggtgacattc aagaatcagg cctcaagacc ctacagtttt     2760

tatagttctc tgatcagcta cccagatgat caggagcagg gggctgaacc aaggcacaac     2820

tttgtgcagc ctaatgagac aagaacttac ttttggaagg tccagcatca catggctccc     2880

acagaggatg agtttgactg caaggcctgg gcatattttt ctgatgtgga cctggagaag     2940

gatgtgcata gtggcctcat tgggccactg ctcatctgca gggcaaacac actgaatgct     3000

gcacatggca ggcaggtcac tgtgcaggag tttgccctgt tctttacaat ctttgatgaa     3060

actaagtcct ggtacttcac agagaatgtg gaaaggaatt gcagagcccc ctgccatctc     3120

cagatggagg acccaactct gaaggaaaac tacaggttcc atgctatcaa tggatatgtc     3180

atggatacac tgccaggcct ggtgatggca cagaaccaga ggatcaggtg gtatctgctc     3240

agcatggggt ccaatgagaa tatccattct atccacttct caggacatgt cttttcagtg     3300

aggaagaaag aggaatataa aatggctgtg tacaatctgt atccaggggt ctttgagaca     3360

gtggaaatgc tgcctagcaa agtggggatc tggagaattg agtgcctcat tggagaacac     3420

ctgcaggcag ggatgtccac cacatttctg gtgtactcaa agaaatgcca gactcccctg     3480

gggatggcaa gtggacatat cagggacttc cagatcactg catcaggaca gtatggacag     3540

tgggcaccaa agctggctag gctccactat agtggctcta tcaatgcttg gagtaccaaa     3600

gagcctttct cttggatcaa ggtggatctg ctggccccca tgatcatcca tggaatcaaa     3660

acacagggag ctagacagaa gttcagctcc ctgtacatca gtcagtttat catcatgtat     3720

tctctggatg ggaagaaatg gcagacctac aggggcaata gcactgggac actgatggtc     3780

ttctttggaa atgtggattc aagtggcatc aagcacaaca tcttcaatcc tcccatcatt     3840

gccaggtaca tcagactgca tcccacacac tattcaatca ggagtactct cagaatggag     3900

ctgatggggt gtgacctcaa cagctgctcc atgccactgg gaatggaatc caaggcaatc     3960

tcagatgccc agatcactgc ttctagctac ttcaccaata tgtttgcaac atggtcaccc     4020

agtaaagcaa ggctgcacct ccagggaagg tccaatgctt ggagacccca ggtgaacaat     4080

ccaaaggagt ggctgcaggt ggactttcag aaaaccatga aggtcacagg ggtgactacc     4140

cagggagtga aaagtctgct cacctctatg tatgtcaagg agttcctgat ctcctcaagt     4200

caggatggcc accagtggac actgttcttt cagaatggca aggtcaaagt gttccagggg     4260

aatcaggaca gctttacacc agtggtgaac agcctggacc cccctctgct cactagatat     4320

ctgagaatcc atccacagag ctgggtgcac cagattgcac tcagaatgga ggtcctgggc     4380

tgtgaagccc aggacctgta ttga                                            4404


<210>  126
<211>  4374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  126
atgcagattg agctcagcac ctgcttcttt ctgtgcctgc tcaggttctg cttttcagcc       60

acaaggagat actatctggg agctgtggaa ctgtcatggg attacatgca gagtgacctg      120

ggagagctcc ctgtggatgc taggttcccc ccaagggtcc caaagtcttt cccttttaat      180

accagtgtgg tctataagaa aacactcttt gtggaattta ctgatcacct gttcaacatt      240

gcaaagccaa ggcctccctg gatgggactg ctgggaccta ccatccaggc tgaggtgtat      300

gacactgtgg tcatcacact gaaaaacatg gcatctcacc ctgtcagcct gcatgcagtg      360

ggagtcagct actggaaggc ttcagaaggg gcagagtatg atgatcagac aagccagaga      420

gaaaaagagg atgataaggt gttcccagga gggagccata cttatgtgtg gcaggtcctg      480

aaggagaatg gcccaatggc cagtgaccca ctgtgcctca cctactcata tctgagtcat      540

gtggacctgg tcaaggatct caactcaggc ctgattgggg cactgctggt gtgcagggaa      600

ggctcactgg ccaaggagaa aacccagaca ctgcataagt tcatcctgct ctttgctgtg      660

tttgatgaag ggaaatcttg gcacagtgag accaagaaca gtctgatgca ggacagggat      720

gctgcttctg ccagagcttg gcccaagatg cacacagtga atggatatgt caataggtcc      780

ctgccaggac tcattggctg ccacagaaag tcagtgtatt ggcatgtcat tggaatgggc      840

accacaccag aagtgcacag catcttcctg gaggggcata cctttctggt caggaaccac      900

aggcaggcca gcctggagat cagcccaatc accttcctga cagcccagac tctgctcatg      960

gatctggggc agttcctgct cttttgccac atcagctccc accagcatga tggaatggag     1020

gcatatgtga aagtggactc ctgcccagag gaaccacagc tgaggatgaa gaacaatgag     1080

gaagctgaag actatgatga tgacctgaca gactcagaga tggatgtggt caggtttgat     1140

gatgataaca gcccctcctt tatccagatc agaagtgtgg ccaagaaaca cccaaagaca     1200

tgggtccatt acattgcagc tgaggaagag gactgggatt atgcacctct ggtgctggcc     1260

ccagatgata gatcctacaa atcacagtat ctgaacaatg gaccccagag gattggcaga     1320

aagtacaaga aagtgaggtt catggcctat actgatgaaa catttaagac tagagaagct     1380

atccagcatg agtcaggcat cctgggacca ctgctctatg gagaagtggg ggacaccctg     1440

ctcatcatct tcaagaacca ggcttccagg ccatacaata tctatcctca tggcatcaca     1500

gatgtgagac cactctactc aaggagactg cctaagggag tcaaacacct caaggacttc     1560

cctatcctgc caggggaaat ctttaagtat aaatggactg tgacagtgga ggatgggccc     1620

actaagagtg acccaaggtg cctgaccaga tactattcaa gttttgtgaa tatggaaagg     1680

gatctggcat caggactgat tggacctctg ctcatctgct acaaagagag tgtggatcag     1740

aggggcaacc agatcatgtc agacaagagg aatgtgatcc tgttcagtgt ctttgatgaa     1800

aacaggtctt ggtatctgac agagaacatc cagagattcc tgccaaatcc tgcaggggtg     1860

cagctggaag atccagagtt tcaggcctca aacatcatgc atagtatcaa tggatatgtg     1920

tttgacagtc tgcagctctc tgtgtgcctg catgaagtgg cctactggta tatcctgtcc     1980

attggagctc agacagattt cctgagtgtg ttcttttcag gctacacttt taagcataaa     2040

atggtctatg aggacacact gactctcttc ccttttagtg gggaaacagt gtttatgagc     2100

atggagaatc cagggctgtg gattctggga tgccacaaca gtgatttcag gaatagaggc     2160

atgactgctc tgctcaaagt gtctagctgt gacaagaaca caggggacta ctatgaagat     2220

tcttatgagg acatcagtgc ttatctgctc tccaaaaaca atgcaattga acccagatca     2280

ttcagtcaga atccacctgt gctgaagagg caccagagag agatcactag gactaccctg     2340

cagtcagatc aggaagagat tgactatgat gataccatct cagtggaaat gaagaaagag     2400

gactttgata tctatgatga agatgagaac cagagtccaa ggtctttcca gaagaaaacc     2460

agacattact ttattgctgc agtggagagg ctgtgggatt atggaatgtc ctcaagtcca     2520

catgtgctga ggaatagggc acagtctggc agtgtccctc agttcaagaa agtggtcttc     2580

caggagttta cagatggcag cttcactcag cctctgtaca ggggagaact caatgagcac     2640

ctggggctgc tgggacccta tatcagagct gaagtggagg ataacatcat ggtcaccttc     2700

aggaatcagg cttcaagacc ctacagtttt tattctagcc tgatcagcta tgaagaggac     2760

cagaggcagg gagctgaacc taggaaaaac tttgtgaagc caaatgagac caaaacatac     2820

ttttggaagg tccagcacca catggcacca accaaagatg agtttgattg caaggcatgg     2880

gcctattttt cagatgtgga tctggagaag gatgtccaca gtggcctcat tgggcctctg     2940

ctggtgtgcc atactaacac cctgaatcca gctcatggca ggcaggtgac agtccaggag     3000

tttgcactgt tctttaccat ctttgatgag acaaagtcct ggtacttcac tgaaaacatg     3060

gagaggaatt gcagagctcc ttgcaacatc cagatggaag accccacctt caaggagaac     3120

tacagatttc atgcaatcaa tgggtatatc atggatacac tgccaggact ggtgatggcc     3180

caggaccaga ggatcagatg gtatctgctc agcatggggt ccaatgagaa tatccactct     3240

atccatttca gtggacatgt gtttacagtc agaaagaaag aagagtataa aatggccctg     3300

tacaacctct atccaggagt gtttgaaaca gtggagatgc tgccaagcaa ggctgggatc     3360

tggagggtgg aatgcctcat tggggagcac ctgcatgcag gaatgtcaac cctgtttctg     3420

gtctacagta ataagtgcca gacacctctg ggaatggcaa gtggacatat cagggatttc     3480

cagatcactg ctagtggaca gtatggacag tgggcaccaa agctggctag actccactat     3540

tcaggctcaa tcaatgcttg gtccaccaaa gagccattct catggatcaa ggtggacctg     3600

ctggctccta tgatcatcca tggcatcaaa acacaggggg caaggcagaa gttctcctca     3660

ctgtacatct ctcagtttat catcatgtat agcctggatg gcaagaaatg gcagacctac     3720

aggggcaata gcacagggac tctgatggtg ttctttggca atgtggacag cagtgggatc     3780

aagcacaaca tcttcaatcc cccaatcatt gcaaggtaca tcagactgca ccccacccat     3840

tattcaatca ggagtacact caggatggaa ctgatggggt gtgatctcaa cagttgctct     3900

atgccactgg gaatggagtc caaggcaatc tcagatgccc agatcactgc tagctcctac     3960

ttcactaata tgtttgctac ctggagcccc tccaaagcaa ggctgcacct ccagggaagg     4020

agcaatgcat ggaggcctca ggtgaacaat cccaaggaat ggctgcaggt ggatttccag     4080

aaaactatga aggtgactgg agtcacaact cagggagtga aaagtctgct cacttctatg     4140

tatgtcaagg agttcctgat ctcaagttct caggatggcc accagtggac cctgttcttt     4200

cagaatggaa aggtgaaagt cttccagggc aatcaggatt cctttacacc agtggtcaac     4260

tcactggacc ctcccctgct cactagatat ctgagaatcc accctcagag ctgggtgcat     4320

cagattgctc tcagaatgga agtcctgggc tgtgaggcac aggacctgta ttga           4374


<210>  127
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  127
atgcagaggg tgaatatgat tatggctgag tcccctgggc tgattaccat ttgcctgctg       60

ggatacctgc tgtctgctga gtgtacagtg ttcctggacc atgagaatgc aaataagatc      120

ctgaacaggc ccaaaagata taatagtgga aagctggagg aatttgtgca gggcaacctg      180

gagagagaat gcatggagga aaagtgtagc tttgaggaag ccagggaggt gtttgaaaat      240

acagagagaa ccacagaatt ctggaagcag tatgtggatg gagatcagtg tgagagcaac      300

ccctgtctga atggagggag ttgcaaagat gatatcaact catatgaatg ctggtgtcct      360

tttggatttg aaggcaaaaa ttgtgagctg gatgtgacct gtaacattaa gaatgggagg      420

tgtgagcagt tttgtaaaaa ctctgctgat aataaggtgg tctgcagttg tacagaaggg      480

tatagactgg ctgagaacca gaagtcctgt gaaccagctg tgcccttccc ttgtggaagg      540

gtgtctgtct cccagacttc aaaactgacc agagctgaga ctgtgtttcc tgatgtggat      600

tatgtcaaca gcacagaggc tgaaactatc ctggacaaca ttactcagtc tacccagagt      660

ttcaatgact ttaccagagt ggtgggagga gaggatgcta aaccaggcca gttcccctgg      720

caggtggtcc tgaatgggaa ggtggatgca ttttgtgggg gatctattgt gaatgagaaa      780

tggattgtca cagctgctca ctgtgtggaa actggggtca agatcacagt ggtggctgga      840

gagcacaaca ttgaggaaac agaacatact gagcagaaga ggaatgtgat cagaatcatt      900

cctcaccata actacaatgc agccatcaac aaatataatc atgacattgc cctgctggaa      960

ctggatgagc ctctggtgct gaacagctat gtcacaccaa tctgcattgc tgacaaggag     1020

tacactaaca tcttcctgaa gtttgggtca ggatatgtgt ctggatgggg aagagtcttc     1080

cacaagggca ggtctgcact ggtgctgcag tatctgagag tgcctctggt ggatagggcc     1140

acttgtctgc tgtctaccaa gttcaccatc tacaacaata tgttctgtgc tggatttcat     1200

gagggaggga gagactcctg tcagggagat tctggaggcc cacatgtgac agaggtggaa     1260

ggcaccagct tcctgacagg catcatttcc tggggggagg aatgtgcaat gaaggggaaa     1320

tatggaatct acaccaaagt gagcaggtat gtgaactgga tcaaggaaaa gaccaaactg     1380

acatga                                                                1386


<210>  128
<211>  252
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  128
tgtttgctgc ttgcaatgtt tgcccatttt agggtggaca caggacgctg tggtttctga       60

gccagggggc gactcagatc ccagccagtg gacttagccc ctgtttgctc ctccgataac      120

tggggtgacc ttggttaata ttcaccagca gcctcccccg ttgcccctct ggatccactg      180

cttaaatacg gacgaggaca gggccctgtc tcctcagctt caggcaccac cactgacctg      240

ggacagtgaa tc                                                          252


<210>  129
<211>  4882
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant AAV sequence

<400>  129
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc taccggtgtt aatcattaag tcgttaattt ttgtggccct      180

tgcgatgttt gctctggtta ataatctcag gacaaacaga ggttaataat tttccagatc      240

tctctgagca atagtataaa aggccagcag cagcctgacc acatctcatc ctcgtcgagc      300

caccatgcag atcgaactgt ctacctgttt ctttctgtgc ctgctgcggt tttgtttttc      360

cgctaccaga agatactacc tgggagccgt cgaactgagc tgggattaca tgcagtctga      420

cctgggagag ctgcccgtgg acgctagatt cccacctaga gtccctaagt ccttcccctt      480

caacaccagc gtggtctaca agaaaaccct gttcgtggag tttaccgacc acctgttcaa      540

catcgctaag cctagaccac catggatggg actgctggga ccaaccatcc aggccgaggt      600

gtacgacacc gtggtcatca ccctgaaaaa catggcttct caccccgtgt ccctgcatgc      660

tgtgggcgtc tcctactgga aggccagcga aggggctgag tatgacgatc agaccagcca      720

gcgggaaaaa gaggacgata aggtgttccc tggcgggtcc catacctacg tgtggcaggt      780

cctgaaggag aatggaccaa tggcttccga ccctctgtgc ctgacctact cttatctgtc      840

ccacgtggac ctggtcaagg atctgaacag cggcctgatc ggggctctgc tggtgtgtcg      900

cgaagggtcc ctggccaagg agaaaaccca gaccctgcat aagttcatcc tgctgttcgc      960

cgtgtttgac gaaggaaaaa gctggcactc tgagaccaag aactctctga tgcaggacag     1020

ggatgccgct tccgccagag cttggcccaa gatgcacacc gtgaacggct acgtcaatag     1080

gagcctgcct ggactgatcg gctgccacag aaagtccgtg tattggcatg tcatcggaat     1140

gggcaccacc cctgaagtgc acagcatctt cctggagggg catacctttc tggtccgcaa     1200

ccaccggcag gctagcctgg agatctctcc aatcaccttc ctgaccgccc agaccctgct     1260

gatggacctg ggacagttcc tgctgttttg ccacatctcc agccaccagc atgatggcat     1320

ggaggcttac gtgaaagtcg actcctgtcc cgaggaacct cagctgagga tgaagaacaa     1380

tgaggaagcc gaagactatg acgatgacct gaccgacagc gagatggatg tggtccgctt     1440

cgatgacgat aactctccct cctttatcca gatccggtcc gtggccaaga aacaccctaa     1500

gacctgggtc cattacatcg ccgctgagga agaggactgg gattatgctc cactggtgct     1560

ggcccccgac gatagatcct acaaaagcca gtatctgaac aatggacccc agaggatcgg     1620

cagaaagtac aagaaagtga ggttcatggc ttataccgat gagaccttta agaccagaga     1680

agccatccag cacgagtccg ggatcctggg acctctgctg tacggcgaag tgggggacac     1740

cctgctgatc atcttcaaga accaggccag caggccttac aatatctatc cacatggcat     1800

caccgatgtg agacctctgt actcccgccg gctgccaaag ggcgtgaaac acctgaagga     1860

cttcccaatc ctgcccgggg aaatctttaa gtataaatgg accgtcaccg tcgaggatgg     1920

gcccaccaag agcgacccta ggtgcctgac cagatactat tcttccttcg tgaatatgga     1980

gagagacctg gcttccggac tgatcggacc cctgctgatc tgttacaaag agagcgtgga     2040

tcagcgcggc aaccagatca tgtctgacaa gcggaatgtg atcctgttca gcgtctttga     2100

cgaaaaccgc tcttggtacc tgaccgagaa catccagcgg ttcctgccta atccagctgg     2160

agtgcagctg gaagatcccg agttccaggc ctctaacatc atgcattcca tcaatggcta     2220

cgtgttcgac tccctgcagc tgagcgtgtg cctgcacgag gtcgcttact ggtatatcct     2280

gagcatcgga gcccagaccg atttcctgtc tgtgttcttt tccggctaca cctttaagca     2340

taaaatggtg tatgaggaca ccctgaccct gttcccattt tccggcgaaa ccgtgttcat     2400

gagcatggag aatcccgggc tgtggatcct gggatgccac aactccgatt tcaggaatag     2460

agggatgacc gccctgctga aagtgagctc ttgtgacaag aacaccggag actactatga     2520

agatagctac gaggacatct ctgcttatct gctgtccaaa aacaatgcca tcgagcccag     2580

gagcttctct cagaaccctc cagtgctgaa gcgccaccag cgggagatca ccagaaccac     2640

cctgcagagc gatcaggaag agatcgacta cgacgatacc atctccgtgg aaatgaagaa     2700

agaggacttc gatatctatg acgaagatga gaaccagtct cccaggtcct tccagaagaa     2760

aaccagacat tactttatcg ccgctgtgga gcggctgtgg gactatggca tgtccagctc     2820

tcctcacgtg ctgagaaata gagctcagtc cggaagcgtc ccacagttca agaaagtggt     2880

cttccaggag tttaccgacg gaagctttac ccagccactg taccgcggcg aactgaacga     2940

gcacctgggg ctgctgggac cctatatccg ggctgaagtg gaggataaca tcatggtcac     3000

cttcaggaat caggccagca gaccctactc tttttattcc agcctgatct cctacgaaga     3060

ggaccagaga cagggagctg aaccaagaaa aaacttcgtg aagcctaatg agaccaaaac     3120

ctacttttgg aaggtgcagc accatatggc ccctaccaaa gacgagttcg attgcaaggc     3180

ctgggcttat tttagcgacg tggatctgga gaaggacgtc cactccggcc tgatcgggcc     3240

actgctggtg tgtcatacca acaccctgaa tccagctcac ggaaggcagg tgaccgtcca     3300

ggaattcgcc ctgttcttta ccatctttga tgagaccaag agctggtact tcaccgaaaa     3360

catggagagg aattgcagag ccccatgtaa catccagatg gaagacccca ccttcaagga     3420

gaactacaga tttcatgcta tcaatgggta tatcatggat accctgccag gactggtcat     3480

ggctcaggac cagaggatca gatggtacct gctgagcatg gggtctaacg agaatatcca     3540

ctccatccat ttcagcggac acgtgtttac cgtccgcaag aaagaagagt acaagatggc     3600

cctgtacaac ctgtatcccg gcgtgttcga aaccgtcgag atgctgcctt ccaaggctgg     3660

gatctggcgg gtggaatgcc tgatcgggga gcacctgcat gccggaatgt ctaccctgtt     3720

cctggtgtac tccaataagt gtcagacccc cctggggatg gctagcggac atatccgcga     3780

cttccagatc accgcttccg gacagtacgg acagtgggct cctaagctgg ctagactgca     3840

ctattctggc tccatcaacg cttggtctac caaagagcct ttctcctgga tcaaggtgga     3900

cctgctggct ccaatgatca tccatggcat caaaacccag ggggccaggc agaagttctc     3960

ttccctgtac atcagccagt ttatcatcat gtattctctg gatgggaaga aatggcagac     4020

ctacagaggc aattccaccg ggaccctgat ggtgttcttt ggcaacgtcg acagctctgg     4080

gatcaagcac aacatcttca atccccctat catcgcccgc tacatccggc tgcacccaac     4140

ccattattcc atccgcagca ccctgcggat ggagctgatg gggtgcgatc tgaacagctg     4200

ttctatgccc ctgggaatgg agtctaaggc catctccgac gctcagatca ccgcctccag     4260

ctacttcacc aatatgtttg ctacctggtc cccaagcaag gctagactgc atctgcaggg     4320

aagaagcaac gcttggagac cacaggtgaa caatcccaag gagtggctgc aggtcgactt     4380

ccagaaaacc atgaaggtga ccggagtcac cacccagggc gtgaaaagcc tgctgacctc     4440

tatgtacgtc aaggagttcc tgatctcttc cagccaggac gggcaccagt ggaccctgtt     4500

ctttcagaac ggaaaggtga aagtcttcca gggcaatcag gattccttta cccctgtggt     4560

caacagcctg gacccacccc tgctgaccag gtacctgaga atccacccac agtcctgggt     4620

gcatcagatc gctctgagga tggaagtcct gggctgcgag gcccaggacc tgtattgagc     4680

ggccgcaata aaatatcttt attttcatta catctgtgtg ttggtttttt gtgtgcaatt     4740

gaggaacccc tagtgatgga gttggccact ccctctctgc gcgctcgctc gctcactgag     4800

gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc agtgagcgag     4860

cgagcgcgca gctgcctgca gg                                              4882


<210>  130
<211>  5018
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant AAV sequence

<400>  130
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc taccggtgtt aatcattaag tcgttaattt ttgtggccct      180

tgcgatgttt gctctggtta ataatctcag gacaaacaga ggttaataat tttccagatc      240

tctctgagca atagtataaa aggccagcag cagcctgacc acatctcatc ctcgtcgact      300

taattaaaag aggtaagggt ttaagggatg gttggttggt ggggtattaa tgtttaatta      360

cctggagcac ctgcctgaaa tcactttttt tcaggttggc tcgagccacc atgcagctgg      420

aactgtctac ctgtgtgttt ctgtgtctgc tgcctctggg gttttctgct atcaggagat      480

actatctggg agctgtggag ctgtcctggg actacaggca gtctgagctg ctgagagaac      540

tgcatgtgga taccagattc ccagctacag ctccaggagc tctgcctctg ggcccatctg      600

tgctgtacaa gaaaacagtc tttgtggagt ttacagacca gctgttctct gtggccaggc      660

caagaccacc ttggatggga ctgctgggac caaccatcca ggctgaggtg tatgatacag      720

tggtggtgac cctgaaaaac atggcctccc atcctgtgag cctgcatgct gtgggggtgt      780

ccttctggaa gtcctctgag ggagctgagt atgaagacca tacctcccag agggagaaag      840

aagatgataa ggtgctgcct ggcaaaagcc agacctatgt ctggcaggtg ctgaaggaga      900

atggaccaac tgcttctgac ccaccatgcc tgacctactc ttatctgtcc catgtggatc      960

tggtgaagga cctgaattct ggactgattg gagctctgct ggtgtgtaga gagggaagcc     1020

tgaccagaga aagaacccag aacctgcatg agtttgtcct gctgtttgct gtgtttgatg     1080

aagggaagag ctggcactct gccaggaatg actcctggac cagagctatg gatccagctc     1140

ctgctagagc tcagcctgct atgcacacag tcaatggcta tgtgaatagg tctctgccag     1200

gactgattgg ctgccataag aaatctgtct attggcatgt gattggaatg ggcaccagcc     1260

ctgaggtgca ttctatcttc ctggaaggcc acacctttct ggtcaggcac catagacagg     1320

cctctctgga gatctcccct ctgaccttcc tgacagctca gacctttctg atggacctgg     1380

ggcagttcct gctgttttgc catatctctt cccaccatca tggaggaatg gaggctcatg     1440

tcagggtgga atcctgtgct gaggaaccac agctgagaag aaaggctgat gaggaagagg     1500

actatgatga taacctgtat gactctgata tggatgtggt gaggctggat ggggatgatg     1560

tcagcccttt catccagatc aggtctgtgg ccaagaaaca tccaaagacc tgggtccact     1620

acattgctgc tgaagaggaa gattgggact atgcccccct ggtgctggct cctgatgata     1680

gatcctacaa aagccagtat ctgaacaatg ggccccagag gattggaagg aagtacaaga     1740

aagtgaggtt catggcctat acagatgaga cctttaagac cagagaggct atccagcatg     1800

aatctgggat cctgggacct ctgctgtatg gagaagtggg ggataccctg ctgatcatct     1860

tcaagaacca ggcctccagg ccatacaata tctatcccca tggcatcaca gatgtgagac     1920

cactgtacag caggagactg cccaaggggg tcaaacacct gaaggatttc cccatcctgc     1980

ctggagagat ctttaagtat aaatggacag tcacagtgga agatgggcct accaagtctg     2040

atccaaggtg cctgaccaga tactatagct cttttgtgaa catggagaga gacctggctt     2100

ctggactgat tggacccctg ctgatctgtt acaaagagtc tgtggaccag aggggcaacc     2160

agatcatgtc tgataagaga aatgtcatcc tgttctctgt gtttgatgag aacaggagct     2220

ggtacctgac agagaacatc cagaggttcc tgccaaatcc agctggagtg cagctggagg     2280

acccagaatt tcaggcttcc aacatcatgc atagcatcaa tggctatgtg tttgatagcc     2340

tgcagctgtc tgtctgcctg catgaggtgg cctactggta tatcctgtcc attggagctc     2400

agacagactt cctgtctgtg ttctttagtg ggtacacctt taagcataaa atggtgtatg     2460

aggataccct gaccctgttc cccttttctg gggagacagt gttcatgtcc atggaaaacc     2520

ctggcctgtg gatcctgggg tgccacaact ctgacttcag gaatagagga atgacagccc     2580

tgctgaaagt gtccagctgt gataagaata caggggatta ctatgaggac tcttatgaag     2640

atatctctgc ttatctgctg agcaagaaca atgccattga gcccaggtct tttgctcaga     2700

actccagacc tccatctgct tctgctccta agccacctgt gctgagaaga catcagaggg     2760

acatctccct gcctaccttc cagccagagg aagataaaat ggactatgat gatatcttca     2820

gcacagagac caagggggaa gattttgaca tctatggaga ggatgaaaac caggatccaa     2880

gatccttcca gaagagaacc agacactact ttattgctgc tgtggagcag ctgtgggact     2940

atgggatgtc tgaaagccca agggccctga ggaacagagc tcagaatgga gaggtgccca     3000

gattcaagaa agtggtgttc agagagtttg ctgatggcag ctttacccag ccatcttaca     3060

ggggggagct gaacaagcat ctggggctgc tgggacccta tatcagagct gaggtggaag     3120

ataacatcat ggtgaccttc aagaatcagg cttctaggcc ctactccttt tattcttccc     3180

tgatctccta ccctgatgat caggagcagg gagctgaacc taggcacaac tttgtgcagc     3240

caaatgagac cagaacctac ttttggaagg tgcagcatca catggctccc acagaggatg     3300

aatttgactg caaagcttgg gcctattttt ctgatgtgga cctggagaag gatgtgcatt     3360

ctggcctgat tgggcctctg ctgatctgta gggccaacac cctgaatgct gctcatggaa     3420

gacaggtcac agtgcaggag tttgctctgt tctttaccat ctttgatgaa accaagagct     3480

ggtacttcac agagaatgtg gaaaggaatt gcagagcccc ctgtcatctg cagatggagg     3540

accctaccct gaaggaaaac tacaggttcc atgccatcaa tggatatgtc atggataccc     3600

tgcctggcct ggtcatggct cagaaccaga ggatcagatg gtacctgctg tctatgggat     3660

ccaatgagaa tatccatagc atccacttct ctggccatgt cttttctgtg aggaagaaag     3720

aggaatacaa aatggctgtg tacaatctgt atcctggggt ctttgagaca gtggaaatgc     3780

tgccaagcaa agtgggaatc tggagaattg agtgcctgat tggggaacac ctgcaggctg     3840

ggatgagcac caccttcctg gtgtactcta agaaatgtca gaccccactg gggatggcct     3900

ctggacatat cagggacttc cagatcacag cttctggaca gtatggacag tgggctccaa     3960

agctggctag actgcactat tctggctcca tcaatgcctg gtctaccaaa gagccattct     4020

cctggatcaa ggtggacctg ctggccccca tgatcatcca tggaatcaaa acccagggag     4080

ctaggcagaa gttcagctct ctgtacatct cccagtttat catcatgtat agcctggatg     4140

ggaagaaatg gcagacctac agaggcaatt ccactgggac cctgatggtc ttctttggaa     4200

atgtggattc ctctggcatc aagcacaaca tcttcaatcc acccatcatt gccaggtaca     4260

tcaggctgca tcctacccac tatagcatca ggtctaccct gagaatggag ctgatgggat     4320

gtgacctgaa cagctgttct atgccactgg gcatggagtc caaggctatc tctgatgccc     4380

agatcacagc ttcttcctac ttcaccaata tgtttgctac ctggtcccca agcaaggcta     4440

gactgcacct gcagggaaga tccaatgctt ggagacccca ggtgaacaat cctaaggagt     4500

ggctgcaggt ggacttccag aaaaccatga aggtcacagg ggtgaccacc cagggagtga     4560

aatctctgct gacctccatg tatgtcaagg agttcctgat cagctcttcc caggatggcc     4620

accagtggac cctgttcttt cagaatggca aggtcaaagt gttccagggg aatcaggact     4680

cttttacccc agtggtgaac tccctggatc ctccactgct gaccaggtac ctgagaatcc     4740

atcctcagag ctgggtgcac cagattgctc tgagaatgga ggtcctggga tgtgaagctc     4800

aggacctgta ttgagcggcc gcaataaaat atctttattt tcattacatc tgtgtgttgg     4860

ttttttgtgt gcaattgagg aacccctagt gatggagttg gccactccct ctctgcgcgc     4920

tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc     4980

ggcctcagtg agcgagcgag cgcgcagctg cctgcagg                             5018


<210>  131
<211>  137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant promoter sequence

<400>  131
gttaattttt aaaaagcagt caaaagtcca agtggccctt gcgagcattt actctctctg       60

tttgctctgg ttaataatct caggagcaca aacagaggtt aataattttc cagatctctc      120

tgagcaatag tataaaa                                                     137


