                         SEQUENCE LISTING

<110>  University of Florida Research Foundation Inc.
 
<120>  DIRECTED DIFFERENTIATION OF PLURIPOTENT STEM CELLS BY BACTERIAL 
       INJECTION OF TALEN PROTEINS

<130>  U1197.70051WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 62/188,339
<151>  2015-07-02

<150>  US 62/148,154
<151>  2015-04-15

<160>  70    

<170>  PatentIn version 3.5

<210>  1
<211>  453
<212>  PRT
<213>  Pseudomonas

<400>  1

Met His Ile Gln Ser Leu Gln Gln Ser Pro Ser Phe Ala Val Glu Leu 
1               5                   10                  15      


His Gln Ala Ala Ser Gly Arg Leu Gly Gln Ile Glu Ala Arg Gln Val 
            20                  25                  30          


Ala Thr Pro Ser Glu Ala Gln Gln Leu Ala Gln Arg Gln Asp Ala Pro 
        35                  40                  45              


Lys Gly Glu Gly Leu Leu Ala Arg Leu Gly Ala Ala Leu Val Arg Pro 
    50                  55                  60                  


Phe Val Ala Ile Met Asp Trp Leu Gly Lys Leu Leu Gly Ser His Ala 
65                  70                  75                  80  


Arg Thr Gly Pro Gln Pro Ser Gln Asp Ala Gln Pro Ala Val Met Ser 
                85                  90                  95      


Ser Ala Val Val Phe Lys Gln Met Val Leu Gln Gln Ala Leu Pro Met 
            100                 105                 110         


Thr Leu Lys Gly Leu Asp Lys Ala Ser Glu Leu Ala Thr Leu Thr Pro 
        115                 120                 125             


Glu Gly Leu Ala Arg Glu His Ser Arg Leu Ala Ser Gly Asp Gly Ala 
    130                 135                 140                 


Leu Arg Ser Leu Ser Thr Ala Leu Ala Gly Ile Arg Ala Gly Ser Gln 
145                 150                 155                 160 


Val Glu Glu Ser Arg Ile Gln Ala Gly Arg Leu Leu Glu Arg Ser Ile 
                165                 170                 175     


Gly Gly Ile Ala Leu Gln Gln Trp Gly Thr Thr Gly Gly Ala Ala Ser 
            180                 185                 190         


Gln Leu Val Leu Asp Ala Ser Pro Glu Leu Arg Arg Glu Ile Thr Asp 
        195                 200                 205             


Gln Leu His Gln Val Met Ser Glu Val Ala Leu Leu Arg Gln Ala Val 
    210                 215                 220                 


Glu Ser Glu Val Ser Arg Val Ser Ala Asp Lys Ala Leu Ala Asp Gly 
225                 230                 235                 240 


Leu Val Lys Arg Phe Gly Ala Asp Ala Glu Lys Tyr Leu Gly Arg Gln 
                245                 250                 255     


Pro Gly Gly Ile His Ser Asp Ala Glu Val Met Ala Leu Gly Leu Tyr 
            260                 265                 270         


Thr Gly Ile His Tyr Ala Asp Leu Asn Arg Ala Leu Arg Gln Gly Gln 
        275                 280                 285             


Glu Leu Asp Ala Gly Gln Lys Leu Ile Asp Gln Gly Met Ser Ala Ala 
    290                 295                 300                 


Phe Glu Lys Ser Gly Gln Ala Glu Gln Val Val Lys Thr Phe Arg Gly 
305                 310                 315                 320 


Thr Arg Gly Gly Asp Ala Phe Asn Ala Val Glu Glu Gly Lys Val Gly 
                325                 330                 335     


His Asp Asp Gly Tyr Leu Ser Thr Ser Leu Asn Pro Gly Val Ala Arg 
            340                 345                 350         


Ser Phe Gly Gln Gly Thr Ile Ser Thr Val Phe Gly Arg Ser Gly Ile 
        355                 360                 365             


Asp Val Ser Gly Ile Ser Asn Tyr Lys Asn Glu Lys Glu Ile Leu Tyr 
    370                 375                 380                 


Asn Lys Glu Thr Asp Met Arg Val Leu Leu Ser Ala Ser Asp Glu Gln 
385                 390                 395                 400 


Gly Val Thr Arg Arg Val Leu Glu Glu Ala Ala Leu Gly Glu Gln Ser 
                405                 410                 415     


Gly His Ser Gln Gly Leu Leu Asp Ala Leu Asp Leu Ala Ser Lys Pro 
            420                 425                 430         


Glu Arg Ser Gly Glu Val Gln Glu Gln Asp Val Arg Leu Arg Met Arg 
        435                 440                 445             


Gly Leu Asp Leu Ala 
    450             


<210>  2
<211>  457
<212>  PRT
<213>  Pseudomonas

<400>  2

Met His Ile Gln Ser Ser Gln Gln Asn Pro Ser Phe Val Ala Glu Leu 
1               5                   10                  15      


Ser Gln Ala Val Ala Gly Arg Leu Gly Gln Val Glu Ala Arg Gln Val 
            20                  25                  30          


Ala Thr Pro Arg Glu Ala Gln Gln Leu Ala Gln Arg Gln Glu Ala Pro 
        35                  40                  45              


Lys Gly Glu Gly Leu Leu Ser Arg Leu Gly Ala Ala Leu Ala Arg Pro 
    50                  55                  60                  


Phe Val Ala Ile Ile Glu Trp Leu Gly Lys Leu Leu Gly Ser Arg Ala 
65                  70                  75                  80  


His Ala Ala Thr Gln Ala Pro Leu Ser Arg Gln Asp Ala Pro Pro Ala 
                85                  90                  95      


Ala Ser Leu Ser Ala Ala Glu Ile Lys Gln Met Met Leu Gln Lys Ala 
            100                 105                 110         


Leu Pro Leu Thr Leu Gly Gly Leu Gly Lys Ala Ser Glu Leu Ala Thr 
        115                 120                 125             


Leu Thr Ala Glu Arg Leu Ala Lys Asp His Thr Arg Leu Ala Ser Gly 
    130                 135                 140                 


Asp Gly Ala Leu Arg Ser Leu Ala Thr Ala Leu Val Gly Ile Arg Asp 
145                 150                 155                 160 


Gly Ser Arg Ile Glu Ala Ser Arg Thr Gln Ala Ala Arg Leu Leu Glu 
                165                 170                 175     


Gln Ser Val Gly Gly Ile Ala Leu Gln Gln Trp Gly Thr Ala Gly Gly 
            180                 185                 190         


Ala Ala Ser Gln His Val Leu Ser Ala Ser Pro Glu Gln Leu Arg Glu 
        195                 200                 205             


Ile Ala Val Gln Leu His Ala Val Met Asp Lys Val Ala Leu Leu Arg 
    210                 215                 220                 


His Ala Val Glu Ser Glu Val Lys Gly Glu Pro Val Asp Lys Ala Leu 
225                 230                 235                 240 


Ala Asp Gly Leu Val Glu His Phe Gly Leu Glu Ala Glu Gln Tyr Leu 
                245                 250                 255     


Gly Glu His Pro Asp Gly Pro Tyr Ser Asp Ala Glu Val Met Ala Leu 
            260                 265                 270         


Gly Leu Tyr Thr Asn Gly Glu Tyr Gln His Leu Asn Arg Ser Leu Arg 
        275                 280                 285             


Gln Gly Arg Glu Leu Asp Ala Gly Gln Ala Leu Ile Asp Arg Gly Met 
    290                 295                 300                 


Ser Ala Ala Phe Glu Lys Ser Gly Pro Ala Glu Gln Val Val Lys Thr 
305                 310                 315                 320 


Phe Arg Gly Thr Gln Gly Arg Asp Ala Phe Glu Ala Val Lys Glu Gly 
                325                 330                 335     


Gln Val Gly His Asp Ala Gly Tyr Leu Ser Thr Ser Arg Asp Pro Gly 
            340                 345                 350         


Val Ala Arg Ser Phe Ala Gly Gln Gly Thr Ile Thr Thr Leu Phe Gly 
        355                 360                 365             


Arg Ser Gly Ile Asp Val Ser Glu Ile Ser Ile Glu Gly Asp Glu Gln 
    370                 375                 380                 


Glu Ile Leu Tyr Asp Lys Gly Thr Asp Met Arg Val Leu Leu Ser Ala 
385                 390                 395                 400 


Lys Asp Gly Gln Gly Val Thr Arg Arg Val Leu Glu Glu Ala Thr Leu 
                405                 410                 415     


Gly Glu Arg Ser Gly His Gly Glu Gly Leu Leu Asp Ala Leu Asp Leu 
            420                 425                 430         


Ala Thr Gly Thr Asp Arg Ser Gly Lys Pro Gln Glu Gln Asp Leu Arg 
        435                 440                 445             


Leu Arg Met Arg Gly Leu Asp Leu Ala 
    450                 455         


<210>  3
<211>  378
<212>  PRT
<213>  Pseudomonas

<400>  3

Met Arg Ile Asp Gly His Arg Gln Val Val Ser Asn Ala Thr Ala Gln 
1               5                   10                  15      


Pro Gly Pro Leu Leu Arg Pro Ala Asp Met Gln Ala Arg Ala Leu Gln 
            20                  25                  30          


Asp Leu Phe Asp Ala Gln Gly Val Gly Val Pro Val Glu His Ala Leu 
        35                  40                  45              


Arg Met Gln Ala Val Ala Arg Gln Thr Asn Thr Val Phe Gly Ile Arg 
    50                  55                  60                  


Pro Val Glu Arg Ile Val Thr Thr Leu Ile Glu Glu Gly Phe Pro Thr 
65                  70                  75                  80  


Lys Gly Phe Ser Val Lys Gly Lys Ser Ser Asn Trp Gly Pro Gln Ala 
                85                  90                  95      


Gly Phe Ile Cys Val Asp Gln His Leu Ser Lys Arg Glu Asp Arg Asp 
            100                 105                 110         


Thr Ala Glu Ile Arg Lys Leu Asn Leu Ala Val Ala Lys Gly Met Asp 
        115                 120                 125             


Gly Gly Ala Tyr Thr Gln Thr Asp Leu Arg Ile Ser Arg Gln Arg Leu 
    130                 135                 140                 


Ala Glu Leu Val Arg Asn Phe Gly Leu Val Ala Asp Gly Val Gly Pro 
145                 150                 155                 160 


Val Arg Leu Leu Thr Ala Gln Gly Pro Ser Gly Lys Arg Tyr Glu Phe 
                165                 170                 175     


Glu Ala Arg Gln Glu Pro Asp Gly Leu Tyr Arg Ile Ser Arg Leu Gly 
            180                 185                 190         


Arg Ser Glu Ala Val Gln Val Leu Ala Ser Pro Ala Cys Gly Leu Ala 
        195                 200                 205             


Met Thr Ala Asp Tyr Asp Leu Phe Leu Val Ala Pro Ser Ile Glu Ala 
    210                 215                 220                 


His Gly Ser Gly Gly Leu Asp Ala Arg Arg Asn Thr Ala Val Arg Tyr 
225                 230                 235                 240 


Thr Pro Leu Gly Ala Lys Asp Pro Leu Ser Glu Asp Gly Phe Tyr Gly 
                245                 250                 255     


Arg Glu Asp Met Ala Arg Gly Asn Ile Thr Pro Arg Thr Arg Gln Leu 
            260                 265                 270         


Val Asp Ala Leu Asn Asp Cys Leu Gly Arg Gly Glu His Arg Glu Met 
        275                 280                 285             


Phe His His Ser Asp Asp Ala Gly Asn Pro Gly Ser His Met Gly Asp 
    290                 295                 300                 


Asn Phe Pro Ala Thr Phe Tyr Leu Pro Arg Ala Met Glu His Arg Val 
305                 310                 315                 320 


Gly Glu Glu Ser Val Arg Phe Asp Glu Val Cys Val Val Ala Asp Arg 
                325                 330                 335     


Lys Ser Phe Ser Leu Leu Val Glu Cys Ile Lys Gly Asn Gly Tyr His 
            340                 345                 350         


Phe Thr Ala His Pro Asp Trp Asn Val Pro Leu Arg Pro Ser Phe Gln 
        355                 360                 365             


Glu Ala Leu Asp Phe Phe Gln Arg Lys Val 
    370                 375             


<210>  4
<211>  687
<212>  PRT
<213>  Pseudomonas

<400>  4

Met His Ile Gln Ser Leu Gly Ala Thr Ala Ser Ser Leu Asn Gln Glu 
1               5                   10                  15      


Pro Val Glu Thr Pro Ser Gln Ala Ala His Lys Ser Ala Ser Leu Arg 
            20                  25                  30          


Gln Glu Pro Ser Gly Gln Gly Leu Gly Val Ala Leu Lys Ser Thr Pro 
        35                  40                  45              


Gly Ile Leu Ser Gly Lys Leu Pro Glu Ser Val Ser Asp Val Arg Phe 
    50                  55                  60                  


Ser Ser Pro Gln Gly Gln Gly Glu Ser Arg Thr Leu Thr Asp Ser Ala 
65                  70                  75                  80  


Gly Pro Arg Gln Ile Thr Leu Arg Gln Phe Glu Asn Gly Val Thr Glu 
                85                  90                  95      


Leu Gln Leu Ser Arg Pro Pro Leu Thr Ser Leu Val Leu Ser Gly Gly 
            100                 105                 110         


Gly Ala Lys Gly Ala Ala Tyr Pro Gly Ala Met Leu Ala Leu Glu Glu 
        115                 120                 125             


Lys Gly Met Leu Asp Gly Ile Arg Ser Met Ser Gly Ser Ser Ala Gly 
    130                 135                 140                 


Gly Ile Thr Ala Ala Leu Leu Ala Ser Gly Met Ser Pro Ala Ala Phe 
145                 150                 155                 160 


Lys Thr Leu Ser Asp Lys Met Asp Leu Ile Ser Leu Leu Asp Ser Ser 
                165                 170                 175     


Asn Lys Lys Leu Lys Leu Phe Gln His Ile Ser Ser Glu Ile Gly Ala 
            180                 185                 190         


Ser Leu Lys Lys Gly Leu Gly Asn Lys Ile Gly Gly Phe Ser Glu Leu 
        195                 200                 205             


Leu Leu Asn Val Leu Pro Arg Ile Asp Ser Arg Ala Glu Pro Leu Glu 
    210                 215                 220                 


Arg Leu Leu Arg Asp Glu Thr Arg Lys Ala Val Leu Gly Gln Ile Ala 
225                 230                 235                 240 


Thr His Pro Glu Val Ala Arg Gln Pro Thr Val Ala Ala Ile Ala Ser 
                245                 250                 255     


Arg Leu Gln Ser Gly Ser Gly Val Thr Phe Gly Asp Leu Asp Arg Leu 
            260                 265                 270         


Ser Ala Tyr Ile Pro Gln Ile Lys Thr Leu Asn Ile Thr Gly Thr Ala 
        275                 280                 285             


Met Phe Glu Gly Arg Pro Gln Leu Val Val Phe Asn Ala Ser His Thr 
    290                 295                 300                 


Pro Asp Leu Glu Val Ala Gln Ala Ala His Ile Ser Gly Ser Phe Pro 
305                 310                 315                 320 


Gly Val Phe Gln Lys Val Ser Leu Ser Asp Gln Pro Tyr Gln Ala Gly 
                325                 330                 335     


Val Glu Trp Thr Glu Phe Gln Asp Gly Gly Val Met Ile Asn Val Pro 
            340                 345                 350         


Val Pro Glu Met Ile Asp Lys Asn Phe Asp Ser Gly Pro Leu Arg Arg 
        355                 360                 365             


Asn Asp Asn Leu Ile Leu Glu Phe Glu Gly Glu Ala Gly Glu Val Ala 
    370                 375                 380                 


Pro Asp Arg Gly Thr Arg Gly Gly Ala Leu Lys Gly Trp Val Val Gly 
385                 390                 395                 400 


Val Pro Ala Leu Gln Ala Arg Glu Met Leu Gln Leu Glu Gly Leu Glu 
                405                 410                 415     


Glu Leu Arg Glu Gln Thr Val Val Val Pro Leu Lys Ser Glu Arg Gly 
            420                 425                 430         


Asp Phe Ser Gly Met Leu Gly Gly Thr Leu Asn Phe Thr Met Pro Asp 
        435                 440                 445             


Glu Ile Lys Ala His Leu Gln Glu Arg Leu Gln Glu Arg Val Gly Glu 
    450                 455                 460                 


His Leu Glu Lys Arg Leu Gln Ala Ser Glu Arg His Thr Phe Ala Ser 
465                 470                 475                 480 


Leu Asp Glu Ala Leu Leu Ala Leu Asp Asp Ser Met Leu Thr Ser Val 
                485                 490                 495     


Ala Gln Gln Asn Pro Glu Ile Thr Asp Gly Ala Val Ala Phe Arg Gln 
            500                 505                 510         


Lys Ala Arg Asp Ala Phe Thr Glu Leu Thr Val Ala Ile Val Ser Ala 
        515                 520                 525             


Asn Gly Leu Ala Gly Arg Leu Lys Leu Asp Glu Ala Met Arg Ser Ala 
    530                 535                 540                 


Leu Gln Arg Leu Asp Ala Leu Ala Asp Thr Pro Glu Arg Leu Ala Trp 
545                 550                 555                 560 


Leu Ala Ala Glu Leu Asn His Ala Asp Asn Val Asp His Gln Gln Leu 
                565                 570                 575     


Leu Asp Ala Met Arg Gly Gln Thr Val Gln Ser Pro Val Leu Ala Ala 
            580                 585                 590         


Ala Leu Ala Glu Ala Gln Arg Arg Lys Val Ala Val Ile Ala Glu Asn 
        595                 600                 605             


Ile Arg Lys Glu Val Ile Phe Pro Ser Leu Tyr Arg Pro Gly Gln Pro 
    610                 615                 620                 


Asp Ser Asn Val Ala Leu Leu Arg Arg Ala Glu Glu Gln Leu Arg His 
625                 630                 635                 640 


Ala Thr Ser Pro Ala Glu Ile Asn Gln Ala Leu Asn Asp Ile Val Asp 
                645                 650                 655     


Asn Tyr Ser Ala Arg Gly Phe Leu Arg Phe Gly Lys Pro Leu Ser Ser 
            660                 665                 670         


Thr Thr Val Glu Met Ala Lys Ala Trp Arg Asn Lys Glu Phe Thr 
        675                 680                 685         


<210>  5
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Met His Ile Gln Ser Leu Gln Gln Ser Pro Ser Phe Ala Val Glu Leu 
1               5                   10                  15      


His 
    


<210>  6
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Met His Ile Gln Ser Leu Gln Gln Ser Pro Ser Phe Ala Val Glu Leu 
1               5                   10                  15      


His Gln Ala Ala Ser Gly Arg Leu Gly Gln Ile Glu Ala Arg Gln Val 
            20                  25                  30          


Ala Thr Pro Ser Glu Ala Gln Gln Leu Ala Gln Arg Gln Asp Ala Pro 
        35                  40                  45              


Lys Gly Glu Gly Leu Leu 
    50                  


<210>  7
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  7

Met His Ile Gln Ser Leu Gln Gln Ser Pro Ser Phe Ala Val Glu Leu 
1               5                   10                  15      


His Gln Ala Ala Ser Gly Arg Leu Gly Gln Ile Glu Ala Arg Gln Val 
            20                  25                  30          


Ala Thr Pro Ser Glu Ala Gln Gln Leu Ala Gln Arg Gln Asp Ala Pro 
        35                  40                  45              


Lys Gly Glu Gly Leu Leu Ala Arg Leu Gly Ala Ala Leu Val Arg Pro 
    50                  55                  60                  


Phe Val Ala Ile Met Asp Trp Leu Gly Lys Leu Leu Gly Ser His Ala 
65                  70                  75                  80  


Arg Thr Gly Pro Gln Pro Ser Gln Asp Ala Gln Pro Ala Val Met Ser 
                85                  90                  95      


<210>  8
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Met His Ile Gln Ser Leu Gln Gln Ser Pro Ser Phe Ala Val Glu Leu 
1               5                   10                  15      


His Gln Ala Ala Ser Gly Arg Leu Gly Gln Ile Glu Ala Arg Gln Val 
            20                  25                  30          


Ala Thr Pro Ser Glu Ala Gln Gln Leu Ala Gln Arg Gln Asp Ala Pro 
        35                  40                  45              


Lys Gly Glu Gly Leu Leu Ala Arg Leu Gly Ala Ala Leu Val Arg Pro 
    50                  55                  60                  


Phe Val Ala Ile Met Asp Trp Leu Gly Lys Leu Leu Gly Ser His Ala 
65                  70                  75                  80  


Arg Thr Gly Pro Gln Pro Ser Gln Asp Ala Gln Pro Ala Val Met Ser 
                85                  90                  95      


Ser Ala Val Val Phe Lys Gln Met Val Leu Gln Gln Ala Leu Pro Met 
            100                 105                 110         


Thr Leu Lys Gly Leu Asp Lys Ala Ser Glu Leu Ala Thr Leu Thr Pro 
        115                 120                 125             


Glu Gly Leu Ala Arg Glu His Ser Arg Leu Ala Ser Gly Asp Gly Ala 
    130                 135                 140                 


Leu Arg Ser Leu Ser Thr Ala Leu Ala Gly Ile Arg Ala Gly Ser Gln 
145                 150                 155                 160 


Val Glu Glu Ser Arg Ile Gln Ala Gly Arg Leu Leu Glu Arg Ser Ile 
                165                 170                 175     


Gly Gly Ile Ala Leu Gln Gln Trp Gly Thr Thr Gly Gly Ala Ala Ser 
            180                 185                 190         


Gln Leu Val Leu Asp Ala Ser Pro Glu Leu Arg Arg Glu Ile Thr Asp 
        195                 200                 205             


Gln Leu His Gln Val Met Ser Glu Val Ala Leu Leu Arg Gln Ala Val 
    210                 215                 220                 


Glu Ser Glu Val Ser Arg Val Ser Ala Asp 
225                 230                 


<210>  9
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  9
ttcaccgggg tggtgcc                                                      17


<210>  10
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  10
ctggacggcg acgtaaa                                                      17


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  11
gtaggactga acgtcttgct c                                                 21


<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  12
gatgggaggc catcacattg t                                                 21


<210>  13
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  13
cctacagctc ctgggcaacg tgctgg                                            26


<210>  14
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  14
ctggacgtag ccttcgggca tggcgg                                            26


<210>  15
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  15
ttttgagaca aggtcttgct ctattg                                            26


<210>  16
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  16
cagtattggc tttgatgtaa agtact                                            26


<210>  17
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  17
aggagctgtt caccggggtg gtgcccatcc tggtctagct ggacggcgac gtaaacggcc       60

acaagttcag cg                                                           72


<210>  18
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  18
aggagctgtt caccggggtg gtgcccatcc tggtcgagct cgacggcgac gtaaacggcc       60

acaagttcag cg                                                           72


<210>  19
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  19
cctgatttta tttctgtagg actgaacgtc ttgcttgaga tgtgatgaag gagatgggag       60

gccatcacat tg                                                           72


<210>  20
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  20

Met Tyr Gln Ser Leu Ala Met Ala Ala Asn His Gly Pro Pro Pro Gly 
1               5                   10                  15      


Ala Tyr Glu Ala Gly Gly Pro Gly Ala Phe Met His Gly Ala Gly Ala 
            20                  25                  30          


Ala Ser Ser Pro Val Tyr Val Pro Thr Pro Arg Val Pro Ser Ser Val 
        35                  40                  45              


Leu Gly Leu Ser Tyr Leu Gln Gly Gly Gly Ala Gly Ser Ala Ser Gly 
    50                  55                  60                  


Gly Ala Ser Gly Gly Ser Ser Gly Gly Ala Ala Ser Gly Ala Gly Pro 
65                  70                  75                  80  


Gly Thr Gln Gln Gly Ser Pro Gly Trp Ser Gln Ala Gly Ala Asp Gly 
                85                  90                  95      


Ala Ala Tyr Thr Pro Pro Pro Val Ser Pro Arg Phe Ser Phe Pro Gly 
            100                 105                 110         


Thr Thr Gly Ser Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Arg Glu 
        115                 120                 125             


Ala Ala Ala Tyr Ser Ser Gly Gly Gly Ala Ala Gly Ala Gly Leu Ala 
    130                 135                 140                 


Gly Arg Glu Gln Tyr Gly Arg Ala Gly Phe Ala Gly Ser Tyr Ser Ser 
145                 150                 155                 160 


Pro Tyr Pro Ala Tyr Met Ala Asp Val Gly Ala Ser Trp Ala Ala Ala 
                165                 170                 175     


Ala Ala Ala Ser Ala Gly Pro Phe Asp Ser Pro Val Leu His Ser Leu 
            180                 185                 190         


Pro Gly Arg Ala Asn Pro Ala Ala Arg His Pro Asn Leu Asp Met Phe 
        195                 200                 205             


Asp Asp Phe Ser Glu Gly Arg Glu Cys Val Asn Cys Gly Ala Met Ser 
    210                 215                 220                 


Thr Pro Leu Trp Arg Arg Asp Gly Thr Gly His Tyr Leu Cys Asn Ala 
225                 230                 235                 240 


Cys Gly Leu Tyr His Lys Met Asn Gly Ile Asn Arg Pro Leu Ile Lys 
                245                 250                 255     


Pro Gln Arg Arg Leu Ser Ala Ser Arg Arg Val Gly Leu Ser Cys Ala 
            260                 265                 270         


Asn Cys Gln Thr Thr Thr Thr Thr Leu Trp Arg Arg Asn Ala Glu Gly 
        275                 280                 285             


Glu Pro Val Cys Asn Ala Cys Gly Leu Tyr Met Lys Leu His Gly Val 
    290                 295                 300                 


Pro Arg Pro Leu Ala Met Arg Lys Glu Gly Ile Gln Thr Arg Lys Arg 
305                 310                 315                 320 


Lys Pro Lys Asn Leu Asn Lys Ser Lys Thr Pro Ala Ala Pro Ser Gly 
                325                 330                 335     


Ser Glu Ser Leu Pro Pro Ala Ser Gly Ala Ser Ser Asn Ser Ser Asn 
            340                 345                 350         


Ala Thr Thr Ser Ser Ser Glu Glu Met Arg Pro Ile Lys Thr Glu Pro 
        355                 360                 365             


Gly Leu Ser Ser His Tyr Gly His Ser Ser Ser Val Ser Gln Thr Phe 
    370                 375                 380                 


Ser Val Ser Ala Met Ser Gly His Gly Pro Ser Ile His Pro Val Leu 
385                 390                 395                 400 


Ser Ala Leu Lys Leu Ser Pro Gln Gly Tyr Ala Ser Pro Val Ser Gln 
                405                 410                 415     


Ser Pro Gln Thr Ser Ser Lys Gln Asp Ser Trp Asn Ser Leu Val Leu 
            420                 425                 430         


Ala Asp Ser His Gly Asp Ile Ile Thr Ala 
        435                 440         


<210>  21
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  21

Met Gly Arg Lys Lys Ile Gln Ile Thr Arg Ile Met Asp Glu Arg Asn 
1               5                   10                  15      


Arg Gln Val Thr Phe Thr Lys Arg Lys Phe Gly Leu Met Lys Lys Ala 
            20                  25                  30          


Tyr Glu Leu Ser Val Leu Cys Asp Cys Glu Ile Ala Leu Ile Ile Phe 
        35                  40                  45              


Asn Ser Thr Asn Lys Leu Phe Gln Tyr Ala Ser Thr Asp Met Asp Lys 
    50                  55                  60                  


Val Leu Leu Lys Tyr Thr Glu Tyr Asn Glu Pro His Glu Ser Arg Thr 
65                  70                  75                  80  


Asn Ser Asp Ile Val Glu Ala Leu Asn Lys Lys Glu Asn Lys Gly Cys 
                85                  90                  95      


Glu Ser Pro Asp Pro Asp Ser Ser Tyr Ala Leu Thr Pro Arg Thr Glu 
            100                 105                 110         


Glu Lys Tyr Lys Lys Ile Asn Glu Glu Phe Asp Asn Met Ile Lys Ser 
        115                 120                 125             


His Lys Ile Pro Ala Val Pro Pro Pro Asn Phe Glu Met Pro Val Ser 
    130                 135                 140                 


Ile Pro Val Ser Ser His Asn Ser Leu Val Tyr Ser Asn Pro Val Ser 
145                 150                 155                 160 


Ser Leu Gly Asn Pro Asn Leu Leu Pro Leu Ala His Pro Ser Leu Gln 
                165                 170                 175     


Arg Asn Ser Met Ser Pro Gly Val Thr His Arg Pro Pro Ser Ala Gly 
            180                 185                 190         


Asn Thr Gly Gly Leu Met Gly Gly Asp Leu Thr Ser Gly Ala Gly Thr 
        195                 200                 205             


Ser Ala Gly Asn Gly Tyr Gly Asn Pro Arg Asn Ser Pro Gly Leu Leu 
    210                 215                 220                 


Val Ser Pro Gly Asn Leu Asn Lys Asn Met Gln Ala Lys Ser Pro Pro 
225                 230                 235                 240 


Pro Met Asn Leu Gly Met Asn Asn Arg Lys Pro Asp Leu Arg Val Leu 
                245                 250                 255     


Ile Pro Pro Gly Ser Lys Asn Thr Met Pro Ser Val Asn Gln Arg Ile 
            260                 265                 270         


Asn Asn Ser Gln Ser Ala Gln Ser Leu Ala Thr Pro Val Val Ser Val 
        275                 280                 285             


Ala Thr Pro Thr Leu Pro Gly Gln Gly Met Gly Gly Tyr Pro Ser Ala 
    290                 295                 300                 


Ile Ser Thr Thr Tyr Gly Thr Glu Tyr Ser Leu Ser Ser Ala Asp Leu 
305                 310                 315                 320 


Ser Ser Leu Ser Gly Phe Asn Thr Ala Ser Ala Leu His Leu Gly Ser 
                325                 330                 335     


Val Thr Gly Trp Gln Gln Gln His Leu His Asn Met Pro Pro Ser Ala 
            340                 345                 350         


Leu Ser Gln Leu Gly Ala Cys Thr Ser Thr His Leu Ser Gln Ser Ser 
        355                 360                 365             


Asn Leu Ser Leu Pro Ser Thr Gln Ser Leu Asn Ile Lys Ser Glu Pro 
    370                 375                 380                 


Val Ser Pro Pro Arg Asp Arg Thr Thr Thr Pro Ser Arg Tyr Pro Gln 
385                 390                 395                 400 


His Thr Arg His Glu Ala Gly Arg Ser Pro Val Asp Ser Leu Ser Ser 
                405                 410                 415     


Cys Ser Ser Ser Tyr Asp Gly Ser Asp Arg Glu Asp His Arg Asn Glu 
            420                 425                 430         


Phe His Ser Pro Ile Gly Leu Thr Arg Pro Ser Pro Asp Glu Arg Glu 
        435                 440                 445             


Ser Pro Ser Val Lys Arg Met Arg Leu Ser Glu Gly Trp Ala Thr 
    450                 455                 460             


<210>  22
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  22

Met Ala Asp Ala Asp Glu Gly Phe Gly Leu Ala His Thr Pro Leu Glu 
1               5                   10                  15      


Pro Asp Ala Lys Asp Leu Pro Cys Asp Ser Lys Pro Glu Ser Ala Leu 
            20                  25                  30          


Gly Ala Pro Ser Lys Ser Pro Ser Ser Pro Gln Ala Ala Phe Thr Gln 
        35                  40                  45              


Gln Gly Met Glu Gly Ile Lys Val Phe Leu His Glu Arg Glu Leu Trp 
    50                  55                  60                  


Leu Lys Phe His Glu Val Gly Thr Glu Met Ile Ile Thr Lys Ala Gly 
65                  70                  75                  80  


Arg Arg Met Phe Pro Ser Tyr Lys Val Lys Val Thr Gly Leu Asn Pro 
                85                  90                  95      


Lys Thr Lys Tyr Ile Leu Leu Met Asp Ile Val Pro Ala Asp Asp His 
            100                 105                 110         


Arg Tyr Lys Phe Ala Asp Asn Lys Trp Ser Val Thr Gly Lys Ala Glu 
        115                 120                 125             


Pro Ala Met Pro Gly Arg Leu Tyr Val His Pro Asp Ser Pro Ala Thr 
    130                 135                 140                 


Gly Ala His Trp Met Arg Gln Leu Val Ser Phe Gln Lys Leu Lys Leu 
145                 150                 155                 160 


Thr Asn Asn His Leu Asp Pro Phe Gly His Ile Ile Leu Asn Ser Met 
                165                 170                 175     


His Lys Tyr Gln Pro Arg Leu His Ile Val Lys Ala Asp Glu Asn Asn 
            180                 185                 190         


Gly Phe Gly Ser Lys Asn Thr Ala Phe Cys Thr His Val Phe Pro Glu 
        195                 200                 205             


Thr Ala Phe Ile Ala Val Thr Ser Tyr Gln Asn His Lys Ile Thr Gln 
    210                 215                 220                 


Leu Lys Ile Glu Asn Asn Pro Phe Ala Lys Gly Phe Arg Gly Ser Asp 
225                 230                 235                 240 


Asp Met Glu Leu His Arg Met Ser Arg Met Gln Ser Lys Glu Tyr Pro 
                245                 250                 255     


Val Val Pro Arg Ser Thr Val Arg Gln Lys Val Ala Ser Asn His Ser 
            260                 265                 270         


Pro Phe Ser Ser Glu Ser Arg Ala Leu Ser Thr Ser Ser Asn Leu Gly 
        275                 280                 285             


Ser Gln Tyr Gln Cys Glu Asn Gly Val Ser Gly Pro Ser Gln Asp Leu 
    290                 295                 300                 


Leu Pro Pro Pro Asn Pro Tyr Pro Leu Pro Gln Glu His Ser Gln Ile 
305                 310                 315                 320 


Tyr His Cys Thr Lys Arg Lys Glu Glu Glu Cys Ser Thr Thr Asp His 
                325                 330                 335     


Pro Tyr Lys Lys Pro Tyr Met Glu Thr Ser Pro Ser Glu Glu Asp Ser 
            340                 345                 350         


Phe Tyr Arg Ser Ser Tyr Pro Gln Gln Gln Gly Leu Gly Ala Ser Tyr 
        355                 360                 365             


Arg Thr Glu Ser Ala Gln Arg Gln Ala Cys Met Tyr Ala Ser Ser Ala 
    370                 375                 380                 


Pro Pro Ser Glu Pro Val Pro Ser Leu Glu Asp Ile Ser Cys Asn Thr 
385                 390                 395                 400 


Trp Pro Ser Met Pro Ser Tyr Ser Ser Cys Thr Val Thr Thr Val Gln 
                405                 410                 415     


Pro Met Asp Arg Leu Pro Tyr Gln His Phe Ser Ala His Phe Thr Ser 
            420                 425                 430         


Gly Pro Leu Val Pro Arg Leu Ala Gly Met Ala Asn His Gly Ser Pro 
        435                 440                 445             


Gln Leu Gly Glu Gly Met Phe Gln His Gln Thr Ser Val Ala His Gln 
    450                 455                 460                 


Pro Val Val Arg Gln Cys Gly Pro Gln Thr Gly Leu Gln Ser Pro Gly 
465                 470                 475                 480 


Thr Leu Gln Pro Pro Glu Phe Leu Tyr Ser His Gly Val Pro Arg Thr 
                485                 490                 495     


Leu Ser Pro His Gln Tyr His Ser Val His Gly Val Gly Met Val Pro 
            500                 505                 510         


Glu Trp Ser Asp Asn Ser 
        515             


<210>  23
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  23

Met His Ile Gln Ser Leu Gln Gln Ser Pro Ser Phe Ala Val Glu Leu 
1               5                   10                  15      


His Gln Ala Ala Ser Gly Arg Leu Gly Gln Ile Glu Ala Arg Gln Val 
            20                  25                  30          


Ala Thr Pro Ser Glu Ala Gln Gln Leu Ala Gln Arg Gln Asp Ala Pro 
        35                  40                  45              


Lys Gly Glu Gly Leu Leu Asp Tyr Lys Asp Asp Asp Asp Lys Glu Leu 
    50                  55                  60                  


Met Tyr Gln Ser Leu Ala Met Ala Ala Asn His Gly Pro Pro Pro Gly 
65                  70                  75                  80  


Ala Tyr Glu Ala Gly Gly Pro Gly Ala Phe Met His Gly Ala Gly Ala 
                85                  90                  95      


Ala Ser Ser Pro Val Tyr Val Pro Thr Pro Arg Val Pro Ser Ser Val 
            100                 105                 110         


Leu Gly Leu Ser Tyr Leu Gln Gly Gly Gly Ala Gly Ser Ala Ser Gly 
        115                 120                 125             


Gly Ala Ser Gly Gly Ser Ser Gly Gly Ala Ala Ser Gly Ala Gly Pro 
    130                 135                 140                 


Gly Thr Gln Gln Gly Ser Pro Gly Trp Ser Gln Ala Gly Ala Asp Gly 
145                 150                 155                 160 


Ala Ala Tyr Thr Pro Pro Pro Val Ser Pro Arg Phe Ser Phe Pro Gly 
                165                 170                 175     


Thr Thr Gly Ser Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Arg Glu 
            180                 185                 190         


Ala Ala Ala Tyr Ser Ser Gly Gly Gly Ala Ala Gly Ala Gly Leu Ala 
        195                 200                 205             


Gly Arg Glu Gln Tyr Gly Arg Ala Gly Phe Ala Gly Ser Tyr Ser Ser 
    210                 215                 220                 


Pro Tyr Pro Ala Tyr Met Ala Asp Val Gly Ala Ser Trp Ala Ala Ala 
225                 230                 235                 240 


Ala Ala Ala Ser Ala Gly Pro Phe Asp Ser Pro Val Leu His Ser Leu 
                245                 250                 255     


Pro Gly Arg Ala Asn Pro Ala Ala Arg His Pro Asn Leu Asp Met Phe 
            260                 265                 270         


Asp Asp Phe Ser Glu Gly Arg Glu Cys Val Asn Cys Gly Ala Met Ser 
        275                 280                 285             


Thr Pro Leu Trp Arg Arg Asp Gly Thr Gly His Tyr Leu Cys Asn Ala 
    290                 295                 300                 


Cys Gly Leu Tyr His Lys Met Asn Gly Ile Asn Arg Pro Leu Ile Lys 
305                 310                 315                 320 


Pro Gln Arg Arg Leu Ser Ala Ser Arg Arg Val Gly Leu Ser Cys Ala 
                325                 330                 335     


Asn Cys Gln Thr Thr Thr Thr Thr Leu Trp Arg Arg Asn Ala Glu Gly 
            340                 345                 350         


Glu Pro Val Cys Asn Ala Cys Gly Leu Tyr Met Lys Leu His Gly Val 
        355                 360                 365             


Pro Arg Pro Leu Ala Met Arg Lys Glu Gly Ile Gln Thr Arg Lys Arg 
    370                 375                 380                 


Lys Pro Lys Asn Leu Asn Lys Ser Lys Thr Pro Ala Ala Pro Ser Gly 
385                 390                 395                 400 


Ser Glu Ser Leu Pro Pro Ala Ser Gly Ala Ser Ser Asn Ser Ser Asn 
                405                 410                 415     


Ala Thr Thr Ser Ser Ser Glu Glu Met Arg Pro Ile Lys Thr Glu Pro 
            420                 425                 430         


Gly Leu Ser Ser His Tyr Gly His Ser Ser Ser Val Ser Gln Thr Phe 
        435                 440                 445             


Ser Val Ser Ala Met Ser Gly His Gly Pro Ser Ile His Pro Val Leu 
    450                 455                 460                 


Ser Ala Leu Lys Leu Ser Pro Gln Gly Tyr Ala Ser Pro Val Ser Gln 
465                 470                 475                 480 


Ser Pro Gln Thr Ser Ser Lys Gln Asp Ser Trp Asn Ser Leu Val Leu 
                485                 490                 495     


Ala Asp Ser His Gly Asp Ile Ile Thr Ala 
            500                 505     


<210>  24
<211>  527
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  24

Met His Ile Gln Ser Leu Gln Gln Ser Pro Ser Phe Ala Val Glu Leu 
1               5                   10                  15      


His Gln Ala Ala Ser Gly Arg Leu Gly Gln Ile Glu Ala Arg Gln Val 
            20                  25                  30          


Ala Thr Pro Ser Glu Ala Gln Gln Leu Ala Gln Arg Gln Asp Ala Pro 
        35                  40                  45              


Lys Gly Glu Gly Leu Leu Asp Tyr Lys Asp Asp Asp Asp Lys Glu Leu 
    50                  55                  60                  


Met Gly Arg Lys Lys Ile Gln Ile Thr Arg Ile Met Asp Glu Arg Asn 
65                  70                  75                  80  


Arg Gln Val Thr Phe Thr Lys Arg Lys Phe Gly Leu Met Lys Lys Ala 
                85                  90                  95      


Tyr Glu Leu Ser Val Leu Cys Asp Cys Glu Ile Ala Leu Ile Ile Phe 
            100                 105                 110         


Asn Ser Thr Asn Lys Leu Phe Gln Tyr Ala Ser Thr Asp Met Asp Lys 
        115                 120                 125             


Val Leu Leu Lys Tyr Thr Glu Tyr Asn Glu Pro His Glu Ser Arg Thr 
    130                 135                 140                 


Asn Ser Asp Ile Val Glu Ala Leu Asn Lys Lys Glu Asn Lys Gly Cys 
145                 150                 155                 160 


Glu Ser Pro Asp Pro Asp Ser Ser Tyr Ala Leu Thr Pro Arg Thr Glu 
                165                 170                 175     


Glu Lys Tyr Lys Lys Ile Asn Glu Glu Phe Asp Asn Met Ile Lys Ser 
            180                 185                 190         


His Lys Ile Pro Ala Val Pro Pro Pro Asn Phe Glu Met Pro Val Ser 
        195                 200                 205             


Ile Pro Val Ser Ser His Asn Ser Leu Val Tyr Ser Asn Pro Val Ser 
    210                 215                 220                 


Ser Leu Gly Asn Pro Asn Leu Leu Pro Leu Ala His Pro Ser Leu Gln 
225                 230                 235                 240 


Arg Asn Ser Met Ser Pro Gly Val Thr His Arg Pro Pro Ser Ala Gly 
                245                 250                 255     


Asn Thr Gly Gly Leu Met Gly Gly Asp Leu Thr Ser Gly Ala Gly Thr 
            260                 265                 270         


Ser Ala Gly Asn Gly Tyr Gly Asn Pro Arg Asn Ser Pro Gly Leu Leu 
        275                 280                 285             


Val Ser Pro Gly Asn Leu Asn Lys Asn Met Gln Ala Lys Ser Pro Pro 
    290                 295                 300                 


Pro Met Asn Leu Gly Met Asn Asn Arg Lys Pro Asp Leu Arg Val Leu 
305                 310                 315                 320 


Ile Pro Pro Gly Ser Lys Asn Thr Met Pro Ser Val Asn Gln Arg Ile 
                325                 330                 335     


Asn Asn Ser Gln Ser Ala Gln Ser Leu Ala Thr Pro Val Val Ser Val 
            340                 345                 350         


Ala Thr Pro Thr Leu Pro Gly Gln Gly Met Gly Gly Tyr Pro Ser Ala 
        355                 360                 365             


Ile Ser Thr Thr Tyr Gly Thr Glu Tyr Ser Leu Ser Ser Ala Asp Leu 
    370                 375                 380                 


Ser Ser Leu Ser Gly Phe Asn Thr Ala Ser Ala Leu His Leu Gly Ser 
385                 390                 395                 400 


Val Thr Gly Trp Gln Gln Gln His Leu His Asn Met Pro Pro Ser Ala 
                405                 410                 415     


Leu Ser Gln Leu Gly Ala Cys Thr Ser Thr His Leu Ser Gln Ser Ser 
            420                 425                 430         


Asn Leu Ser Leu Pro Ser Thr Gln Ser Leu Asn Ile Lys Ser Glu Pro 
        435                 440                 445             


Val Ser Pro Pro Arg Asp Arg Thr Thr Thr Pro Ser Arg Tyr Pro Gln 
    450                 455                 460                 


His Thr Arg His Glu Ala Gly Arg Ser Pro Val Asp Ser Leu Ser Ser 
465                 470                 475                 480 


Cys Ser Ser Ser Tyr Asp Gly Ser Asp Arg Glu Asp His Arg Asn Glu 
                485                 490                 495     


Phe His Ser Pro Ile Gly Leu Thr Arg Pro Ser Pro Asp Glu Arg Glu 
            500                 505                 510         


Ser Pro Ser Val Lys Arg Met Arg Leu Ser Glu Gly Trp Ala Thr 
        515                 520                 525         


<210>  25
<211>  582
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  25

Met His Ile Gln Ser Leu Gln Gln Ser Pro Ser Phe Ala Val Glu Leu 
1               5                   10                  15      


His Gln Ala Ala Ser Gly Arg Leu Gly Gln Ile Glu Ala Arg Gln Val 
            20                  25                  30          


Ala Thr Pro Ser Glu Ala Gln Gln Leu Ala Gln Arg Gln Asp Ala Pro 
        35                  40                  45              


Lys Gly Glu Gly Leu Leu Asp Tyr Lys Asp Asp Asp Asp Lys Glu Leu 
    50                  55                  60                  


Met Ala Asp Ala Asp Glu Gly Phe Gly Leu Ala His Thr Pro Leu Glu 
65                  70                  75                  80  


Pro Asp Ala Lys Asp Leu Pro Cys Asp Ser Lys Pro Glu Ser Ala Leu 
                85                  90                  95      


Gly Ala Pro Ser Lys Ser Pro Ser Ser Pro Gln Ala Ala Phe Thr Gln 
            100                 105                 110         


Gln Gly Met Glu Gly Ile Lys Val Phe Leu His Glu Arg Glu Leu Trp 
        115                 120                 125             


Leu Lys Phe His Glu Val Gly Thr Glu Met Ile Ile Thr Lys Ala Gly 
    130                 135                 140                 


Arg Arg Met Phe Pro Ser Tyr Lys Val Lys Val Thr Gly Leu Asn Pro 
145                 150                 155                 160 


Lys Thr Lys Tyr Ile Leu Leu Met Asp Ile Val Pro Ala Asp Asp His 
                165                 170                 175     


Arg Tyr Lys Phe Ala Asp Asn Lys Trp Ser Val Thr Gly Lys Ala Glu 
            180                 185                 190         


Pro Ala Met Pro Gly Arg Leu Tyr Val His Pro Asp Ser Pro Ala Thr 
        195                 200                 205             


Gly Ala His Trp Met Arg Gln Leu Val Ser Phe Gln Lys Leu Lys Leu 
    210                 215                 220                 


Thr Asn Asn His Leu Asp Pro Phe Gly His Ile Ile Leu Asn Ser Met 
225                 230                 235                 240 


His Lys Tyr Gln Pro Arg Leu His Ile Val Lys Ala Asp Glu Asn Asn 
                245                 250                 255     


Gly Phe Gly Ser Lys Asn Thr Ala Phe Cys Thr His Val Phe Pro Glu 
            260                 265                 270         


Thr Ala Phe Ile Ala Val Thr Ser Tyr Gln Asn His Lys Ile Thr Gln 
        275                 280                 285             


Leu Lys Ile Glu Asn Asn Pro Phe Ala Lys Gly Phe Arg Gly Ser Asp 
    290                 295                 300                 


Asp Met Glu Leu His Arg Met Ser Arg Met Gln Ser Lys Glu Tyr Pro 
305                 310                 315                 320 


Val Val Pro Arg Ser Thr Val Arg Gln Lys Val Ala Ser Asn His Ser 
                325                 330                 335     


Pro Phe Ser Ser Glu Ser Arg Ala Leu Ser Thr Ser Ser Asn Leu Gly 
            340                 345                 350         


Ser Gln Tyr Gln Cys Glu Asn Gly Val Ser Gly Pro Ser Gln Asp Leu 
        355                 360                 365             


Leu Pro Pro Pro Asn Pro Tyr Pro Leu Pro Gln Glu His Ser Gln Ile 
    370                 375                 380                 


Tyr His Cys Thr Lys Arg Lys Glu Glu Glu Cys Ser Thr Thr Asp His 
385                 390                 395                 400 


Pro Tyr Lys Lys Pro Tyr Met Glu Thr Ser Pro Ser Glu Glu Asp Ser 
                405                 410                 415     


Phe Tyr Arg Ser Ser Tyr Pro Gln Gln Gln Gly Leu Gly Ala Ser Tyr 
            420                 425                 430         


Arg Thr Glu Ser Ala Gln Arg Gln Ala Cys Met Tyr Ala Ser Ser Ala 
        435                 440                 445             


Pro Pro Ser Glu Pro Val Pro Ser Leu Glu Asp Ile Ser Cys Asn Thr 
    450                 455                 460                 


Trp Pro Ser Met Pro Ser Tyr Ser Ser Cys Thr Val Thr Thr Val Gln 
465                 470                 475                 480 


Pro Met Asp Arg Leu Pro Tyr Gln His Phe Ser Ala His Phe Thr Ser 
                485                 490                 495     


Gly Pro Leu Val Pro Arg Leu Ala Gly Met Ala Asn His Gly Ser Pro 
            500                 505                 510         


Gln Leu Gly Glu Gly Met Phe Gln His Gln Thr Ser Val Ala His Gln 
        515                 520                 525             


Pro Val Val Arg Gln Cys Gly Pro Gln Thr Gly Leu Gln Ser Pro Gly 
    530                 535                 540                 


Thr Leu Gln Pro Pro Glu Phe Leu Tyr Ser His Gly Val Pro Arg Thr 
545                 550                 555                 560 


Leu Ser Pro His Gln Tyr His Ser Val His Gly Val Gly Met Val Pro 
                565                 570                 575     


Glu Trp Ser Asp Asn Ser 
            580         


<210>  26
<211>  1380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  26

Met Ala Ser Ser Pro Pro Lys Lys Lys Arg Lys Val Ser Trp Lys Asp 
1               5                   10                  15      


Ala Ser Gly Trp Ser Arg Met His Ala Asp Pro Ile Arg Pro Arg Arg 
            20                  25                  30          


Pro Ser Pro Ala Arg Glu Leu Leu Pro Gly Pro Gln Pro Asp Arg Val 
        35                  40                  45              


Gln Pro Thr Ala Asp Arg Gly Val Ser Ala Pro Ala Gly Ser Pro Leu 
    50                  55                  60                  


Asp Gly Leu Pro Ala Arg Arg Thr Val Ser Arg Thr Arg Leu Pro Ser 
65                  70                  75                  80  


Pro Pro Ala Pro Ser Pro Ala Phe Ser Ala Gly Ser Phe Ser Asp Leu 
                85                  90                  95      


Leu Arg Pro Phe Asp Pro Ser Leu Leu Asp Thr Ser Leu Leu Asp Ser 
            100                 105                 110         


Met Pro Ala Val Gly Thr Pro His Thr Ala Ala Ala Pro Ala Glu Trp 
        115                 120                 125             


Asp Glu Ala Gln Ser Ala Leu Arg Ala Ala Asp Asp Pro Pro Pro Thr 
    130                 135                 140                 


Val Arg Val Ala Val Thr Ala Ala Arg Pro Pro Arg Ala Lys Pro Ala 
145                 150                 155                 160 


Pro Arg Arg Arg Ala Ala Gln Pro Ser Asp Ala Ser Pro Ala Ala Gln 
                165                 170                 175     


Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile 
            180                 185                 190         


Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val 
        195                 200                 205             


Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro 
    210                 215                 220                 


Ala Ala Leu Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr Ala 
225                 230                 235                 240 


Leu Pro Glu Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp 
                245                 250                 255     


Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu Leu 
            260                 265                 270         


Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile Ala 
        275                 280                 285             


Lys Arg Gly Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg Asn 
    290                 295                 300                 


Ala Leu Thr Gly Ala Pro Leu Glu Thr Gly Ala Ala Thr Gly Arg Val 
305                 310                 315                 320 


Pro Phe Ala Ile Gln Ala Ala Gln Leu Leu Gly Arg Ala Ile Gly Ala 
                325                 330                 335     


Gly Leu Phe Ala Ile Thr Pro Ala Gly Glu Arg Gly Met Cys Cys Lys 
            340                 345                 350         


Ala Ile Lys Leu Gly Asn Ala Arg Val Phe Pro Val Thr Thr Leu Leu 
        355                 360                 365             


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
    370                 375                 380                 


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
385                 390                 395                 400 


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly 
                405                 410                 415     


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
            420                 425                 430         


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp 
        435                 440                 445             


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
    450                 455                 460                 


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
465                 470                 475                 480 


Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                485                 490                 495     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            500                 505                 510         


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        515                 520                 525             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    530                 535                 540                 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
545                 550                 555                 560 


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
                565                 570                 575     


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr 
            580                 585                 590         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
        595                 600                 605             


Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu 
    610                 615                 620                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
625                 630                 635                 640 


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
                645                 650                 655     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
            660                 665                 670         


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly 
        675                 680                 685             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    690                 695                 700                 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly 
705                 710                 715                 720 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                725                 730                 735     


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
            740                 745                 750         


Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        755                 760                 765             


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
    770                 775                 780                 


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
785                 790                 795                 800 


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
                805                 810                 815     


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            820                 825                 830         


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
        835                 840                 845             


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr 
    850                 855                 860                 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
865                 870                 875                 880 


Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu 
                885                 890                 895     


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
            900                 905                 910         


Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln 
        915                 920                 925             


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
    930                 935                 940                 


Gly Met Ser Glu Leu Thr His Ile Asn Cys Val Ala Leu Thr Ala Arg 
945                 950                 955                 960 


Phe Pro Pro Val Val Ser Asn Asp His Leu Val Ala Leu Ala Cys Leu 
                965                 970                 975     


Gly Gly Arg Pro Ala Met Asp Ala Val Lys Lys Gly Leu Pro His Ala 
            980                 985                 990         


Pro Glu Leu Ile Arg Arg Val Asn  Arg Arg Ile Gly Glu  Arg Thr Ser 
        995                 1000                 1005             


His Arg  Val Ala Asp Tyr Ala  Gln Val Val Arg Val  Leu Glu Phe 
    1010                 1015                 1020             


Phe Gln  Cys His Ser His Pro  Ala Tyr Ala Phe Asp  Glu Ala Met 
    1025                 1030                 1035             


Thr Gln  Phe Gly Met Ser Arg  Asn Gly Leu Val Gln  Leu Phe Arg 
    1040                 1045                 1050             


Arg Val  Gly Val Thr Glu Leu  Glu Ala Arg Gly Gly  Thr Leu Pro 
    1055                 1060                 1065             


Pro Ala  Ser Gln Arg Trp Asp  Arg Ile Leu Gln Ala  Ser Gly Met 
    1070                 1075                 1080             


Lys Arg  Ala Lys Pro Ser Pro  Thr Ser Ala Gln Thr  Pro Asp Gln 
    1085                 1090                 1095             


Ala Ser  Leu His Ala Phe Ala  Asp Ser Leu Glu Arg  Asp Leu Asp 
    1100                 1105                 1110             


Ala Pro  Ser Pro Met His Glu  Gly Asp Gln Thr Arg  Ala Ser Ser 
    1115                 1120                 1125             


Arg Lys  Arg Ser Arg Ser Asp  Arg Ala Val Thr Gly  Pro Ser Ala 
    1130                 1135                 1140             


Gln Gln  Ala Val Glu Val Arg  Val Pro Glu Gln Arg  Asp Ala Leu 
    1145                 1150                 1155             


His Leu  Pro Leu Ser Trp Arg  Val Lys Arg Pro Arg  Thr Arg Ile 
    1160                 1165                 1170             


Trp Gly  Gly Leu Pro Asp Pro  Ile Ser Arg Ser Gln  Leu Val Lys 
    1175                 1180                 1185             


Ser Glu  Leu Glu Glu Lys Lys  Ser Glu Leu Arg His  Lys Leu Lys 
    1190                 1195                 1200             


Tyr Val  Pro His Glu Tyr Ile  Glu Leu Ile Glu Ile  Ala Arg Asn 
    1205                 1210                 1215             


Ser Thr  Gln Asp Arg Ile Leu  Glu Met Lys Val Met  Glu Phe Phe 
    1220                 1225                 1230             


Met Lys  Val Tyr Gly Tyr Arg  Gly Lys His Leu Gly  Gly Ser Arg 
    1235                 1240                 1245             


Lys Pro  Asp Gly Ala Ile Tyr  Thr Val Gly Ser Pro  Ile Asp Tyr 
    1250                 1255                 1260             


Gly Val  Ile Val Asp Thr Lys  Ala Tyr Ser Gly Gly  Tyr Asn Leu 
    1265                 1270                 1275             


Pro Ile  Gly Gln Ala Asp Glu  Met Gln Arg Tyr Val  Glu Glu Asn 
    1280                 1285                 1290             


Gln Thr  Arg Asn Lys His Ile  Asn Pro Asn Glu Trp  Trp Lys Val 
    1295                 1300                 1305             


Tyr Pro  Ser Ser Val Thr Glu  Phe Lys Phe Leu Phe  Val Ser Gly 
    1310                 1315                 1320             


His Phe  Lys Gly Asn Tyr Lys  Ala Gln Leu Thr Arg  Leu Asn His 
    1325                 1330                 1335             


Ile Thr  Asn Cys Asn Gly Ala  Val Leu Ser Val Glu  Glu Leu Leu 
    1340                 1345                 1350             


Ile Gly  Gly Glu Met Ile Lys  Ala Gly Thr Leu Thr  Leu Glu Glu 
    1355                 1360                 1365             


Val Arg  Arg Lys Phe Asn Asn  Gly Glu Ile Asn Phe  
    1370                 1375                 1380 


<210>  27
<211>  1376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  27

Met Asn Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys His Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Leu Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Asp Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Thr Glu Glu Met Ser Lys Val Asp Ile 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Val Pro Glu Asp Lys 
            100                 105                 110         


Arg Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Glu Glu Glu Lys Glu 
        115                 120                 125             


Tyr His Lys Asn Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Ala Asp Phe Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Ile Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ser Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Ser Ile 
            180                 185                 190         


Tyr Asp Asn Thr Phe Glu Gly Ser Ser Leu Asn Gly Gln Asn Ala Gln 
        195                 200                 205             


Val Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu 
    210                 215                 220                 


Arg Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Val Gln Ile Gly Asp Asp Phe Ala 
        275                 280                 285             


Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Asp Arg Tyr Glu Asn His Gln Lys Asp Leu Ala Ala Leu 
                325                 330                 335     


Lys Gln Phe Ile Lys Thr Asn Leu Pro Glu Lys Tyr Asp Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Leu 
    370                 375                 380                 


Glu Gly Ala Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Ala Ile Ile Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Phe Leu Gln Glu Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Lys Ala Arg Ser Ala Glu Asp Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Gly 
    530                 535                 540                 


Gln Lys Gln Gln Ile Val Thr Gln Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Gln Tyr Leu His Asn Val Asp Ser Tyr Asp 
                565                 570                 575     


Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Glu Phe Met Asp 
        595                 600                 605             


Asp Ser Lys Asn Glu Ala Ile Leu Glu Asn Ile Val His Thr Leu Thr 
    610                 615                 620                 


Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala His Tyr Ala 
625                 630                 635                 640 


Ser Ile Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Tyr Asp 
            660                 665                 670         


Lys Gln Ser Lys Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Glu 
        675                 680                 685             


Ile Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe 
    690                 695                 700                 


Lys Glu Ile Ile Gln Lys Ala Gln Val Val Gly Lys Thr Asn Asp Val 
705                 710                 715                 720 


Lys Gln Val Val Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Ile Lys Leu Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Ala Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu 
    770                 775                 780                 


Asp Ala Leu Lys Asn Leu Ala His Gly Leu Asp Ser Asn Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Ile Gln Leu Gln Asn Asp Arg Leu Phe Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Lys Ser Leu Asp 
            820                 825                 830         


Ile Asn Gln Leu Ser Ser Cys Asp Ile Asp His Ile Ile Pro Gln Ala 
        835                 840                 845             


Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Ser Lys 
    850                 855                 860                 


Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Ile Val Gln 
865                 870                 875                 880 


Lys Arg Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser 
                885                 890                 895     


Glu Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Asp 
            900                 905                 910         


Glu Arg Asp Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala Arg Phe Asn Thr 
    930                 935                 940                 


Glu Val Thr Glu Lys Asp Lys Lys Asp Arg Ser Val Lys Ile Ile Thr 
945                 950                 955                 960 


Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Arg Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Pro Tyr Leu 
            980                 985                 990         


Asn Ala Val Val Ala Lys Ala Ile  Leu Lys Lys Tyr Pro  Lys Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Asp  Tyr Gln Lys Tyr Asp  Leu Lys Arg 
    1010                 1015                 1020             


Tyr Ile  Ser Arg Thr Lys Asp  Pro Lys Glu Val Glu  Lys Ala Thr 
    1025                 1030                 1035             


Glu Lys  Tyr Phe Phe Tyr Ser  Asn Leu Leu Asn Phe  Phe Lys Glu 
    1040                 1045                 1050             


Glu Val  His Tyr Ala Asp Gly  Thr Ile Val Lys Arg  Glu Asn Ile 
    1055                 1060                 1065             


Glu Tyr  Ser Lys Asp Thr Gly  Glu Ile Ala Trp Asn  Lys Glu Lys 
    1070                 1075                 1080             


Asp Phe  Ala Thr Ile Lys Lys  Val Leu Ser Leu Pro  Gln Val Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Thr Glu Glu  Gln Thr Val Gly Gln  Asn Gly Gly 
    1100                 1105                 1110             


Leu Phe  Asp Asn Asn Ile Val  Ser Lys Lys Lys Val  Val Asp Ala 
    1115                 1120                 1125             


Ser Lys  Leu Thr Pro Ile Lys  Ser Gly Leu Ser Pro  Glu Lys Tyr 
    1130                 1135                 1140             


Gly Gly  Tyr Ala Arg Pro Thr  Ile Ala Tyr Ser Val  Leu Val Ile 
    1145                 1150                 1155             


Ala Asp  Ile Glu Lys Gly Lys  Ala Lys Lys Leu Lys  Arg Ile Lys 
    1160                 1165                 1170             


Glu Met  Val Gly Ile Thr Val  Gln Asp Lys Lys Lys  Phe Glu Ala 
    1175                 1180                 1185             


Asn Pro  Ile Ala Tyr Leu Glu  Glu Cys Gly Tyr Lys  Asn Ile Asn 
    1190                 1195                 1200             


Pro Asn  Leu Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Phe 
    1205                 1210                 1215             


Asn Asn  Gly Gln Arg Arg Leu  Leu Ala Ser Ser Ile  Glu Leu Gln 
    1220                 1225                 1230             


Lys Gly  Asn Glu Leu Ile Val  Pro Tyr His Phe Thr  Ala Leu Leu 
    1235                 1240                 1245             


Tyr His  Ala Gln Arg Ile Asn  Lys Ile Ser Glu Pro  Ile His Lys 
    1250                 1255                 1260             


Gln Tyr  Val Glu Thr His Gln  Ser Glu Phe Lys Glu  Leu Leu Thr 
    1265                 1270                 1275             


Ala Ile  Ile Ser Leu Ser Lys  Lys Tyr Ile Gln Lys  Pro Asn Val 
    1280                 1285                 1290             


Glu Ser  Leu Leu Gln Gln Ala  Phe Asp Gln Ser Asp  Lys Asp Ile 
    1295                 1300                 1305             


Tyr Gln  Leu Ser Glu Ser Phe  Ile Ser Leu Leu Lys  Leu Ile Ser 
    1310                 1315                 1320             


Phe Gly  Ala Pro Gly Thr Phe  Lys Phe Leu Gly Val  Glu Ile Ser 
    1325                 1330                 1335             


Gln Ser  Asn Val Arg Tyr Gln  Ser Val Ser Ser Cys  Phe Asn Ala 
    1340                 1345                 1350             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1355                 1360                 1365             


Asp Leu  Ser Lys Leu Gly Glu  Asp 
    1370                 1375     


<210>  28
<211>  1444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  28

Met His Ile Gln Ser Leu Gln Gln Ser Pro Ser Phe Ala Val Glu Leu 
1               5                   10                  15      


His Gln Ala Ala Ser Gly Arg Leu Gly Gln Ile Glu Ala Arg Gln Val 
            20                  25                  30          


Ala Thr Pro Ser Glu Ala Gln Gln Leu Ala Gln Arg Gln Asp Ala Pro 
        35                  40                  45              


Lys Gly Glu Gly Leu Leu Asp Tyr Lys Asp Asp Asp Asp Lys Glu Leu 
    50                  55                  60                  


Met Ala Ser Ser Pro Pro Lys Lys Lys Arg Lys Val Ser Trp Lys Asp 
65                  70                  75                  80  


Ala Ser Gly Trp Ser Arg Met His Ala Asp Pro Ile Arg Pro Arg Arg 
                85                  90                  95      


Pro Ser Pro Ala Arg Glu Leu Leu Pro Gly Pro Gln Pro Asp Arg Val 
            100                 105                 110         


Gln Pro Thr Ala Asp Arg Gly Val Ser Ala Pro Ala Gly Ser Pro Leu 
        115                 120                 125             


Asp Gly Leu Pro Ala Arg Arg Thr Val Ser Arg Thr Arg Leu Pro Ser 
    130                 135                 140                 


Pro Pro Ala Pro Ser Pro Ala Phe Ser Ala Gly Ser Phe Ser Asp Leu 
145                 150                 155                 160 


Leu Arg Pro Phe Asp Pro Ser Leu Leu Asp Thr Ser Leu Leu Asp Ser 
                165                 170                 175     


Met Pro Ala Val Gly Thr Pro His Thr Ala Ala Ala Pro Ala Glu Trp 
            180                 185                 190         


Asp Glu Ala Gln Ser Ala Leu Arg Ala Ala Asp Asp Pro Pro Pro Thr 
        195                 200                 205             


Val Arg Val Ala Val Thr Ala Ala Arg Pro Pro Arg Ala Lys Pro Ala 
    210                 215                 220                 


Pro Arg Arg Arg Ala Ala Gln Pro Ser Asp Ala Ser Pro Ala Ala Gln 
225                 230                 235                 240 


Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile 
                245                 250                 255     


Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val 
            260                 265                 270         


Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro 
        275                 280                 285             


Ala Ala Leu Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr Ala 
    290                 295                 300                 


Leu Pro Glu Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp 
305                 310                 315                 320 


Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu Leu 
                325                 330                 335     


Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile Ala 
            340                 345                 350         


Lys Arg Gly Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg Asn 
        355                 360                 365             


Ala Leu Thr Gly Ala Pro Leu Glu Thr Gly Ala Ala Thr Gly Arg Val 
    370                 375                 380                 


Pro Phe Ala Ile Gln Ala Ala Gln Leu Leu Gly Arg Ala Ile Gly Ala 
385                 390                 395                 400 


Gly Leu Phe Ala Ile Thr Pro Ala Gly Glu Arg Gly Met Cys Cys Lys 
                405                 410                 415     


Ala Ile Lys Leu Gly Asn Ala Arg Val Phe Pro Val Thr Thr Leu Leu 
            420                 425                 430         


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
        435                 440                 445             


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
    450                 455                 460                 


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly 
465                 470                 475                 480 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
                485                 490                 495     


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp 
            500                 505                 510         


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
        515                 520                 525             


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
    530                 535                 540                 


Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
545                 550                 555                 560 


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
                565                 570                 575     


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
            580                 585                 590         


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
        595                 600                 605             


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
    610                 615                 620                 


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
625                 630                 635                 640 


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr 
                645                 650                 655     


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
            660                 665                 670         


Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu 
        675                 680                 685             


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
    690                 695                 700                 


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
705                 710                 715                 720 


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
                725                 730                 735     


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly 
            740                 745                 750         


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
        755                 760                 765             


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly 
    770                 775                 780                 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
785                 790                 795                 800 


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
                805                 810                 815     


Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
            820                 825                 830         


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
        835                 840                 845             


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
    850                 855                 860                 


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
865                 870                 875                 880 


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
                885                 890                 895     


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
            900                 905                 910         


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr 
        915                 920                 925             


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
    930                 935                 940                 


Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu 
945                 950                 955                 960 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
                965                 970                 975     


Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln 
            980                 985                 990         


Ala Leu Glu Thr Val Gln Arg Leu  Leu Pro Val Leu Cys  Gln Asp His 
        995                 1000                 1005             


Gly Met  Ser Glu Leu Thr His  Ile Asn Cys Val Ala  Leu Thr Ala 
    1010                 1015                 1020             


Arg Phe  Pro Pro Val Val Ser  Asn Asp His Leu Val  Ala Leu Ala 
    1025                 1030                 1035             


Cys Leu  Gly Gly Arg Pro Ala  Met Asp Ala Val Lys  Lys Gly Leu 
    1040                 1045                 1050             


Pro His  Ala Pro Glu Leu Ile  Arg Arg Val Asn Arg  Arg Ile Gly 
    1055                 1060                 1065             


Glu Arg  Thr Ser His Arg Val  Ala Asp Tyr Ala Gln  Val Val Arg 
    1070                 1075                 1080             


Val Leu  Glu Phe Phe Gln Cys  His Ser His Pro Ala  Tyr Ala Phe 
    1085                 1090                 1095             


Asp Glu  Ala Met Thr Gln Phe  Gly Met Ser Arg Asn  Gly Leu Val 
    1100                 1105                 1110             


Gln Leu  Phe Arg Arg Val Gly  Val Thr Glu Leu Glu  Ala Arg Gly 
    1115                 1120                 1125             


Gly Thr  Leu Pro Pro Ala Ser  Gln Arg Trp Asp Arg  Ile Leu Gln 
    1130                 1135                 1140             


Ala Ser  Gly Met Lys Arg Ala  Lys Pro Ser Pro Thr  Ser Ala Gln 
    1145                 1150                 1155             


Thr Pro  Asp Gln Ala Ser Leu  His Ala Phe Ala Asp  Ser Leu Glu 
    1160                 1165                 1170             


Arg Asp  Leu Asp Ala Pro Ser  Pro Met His Glu Gly  Asp Gln Thr 
    1175                 1180                 1185             


Arg Ala  Ser Ser Arg Lys Arg  Ser Arg Ser Asp Arg  Ala Val Thr 
    1190                 1195                 1200             


Gly Pro  Ser Ala Gln Gln Ala  Val Glu Val Arg Val  Pro Glu Gln 
    1205                 1210                 1215             


Arg Asp  Ala Leu His Leu Pro  Leu Ser Trp Arg Val  Lys Arg Pro 
    1220                 1225                 1230             


Arg Thr  Arg Ile Trp Gly Gly  Leu Pro Asp Pro Ile  Ser Arg Ser 
    1235                 1240                 1245             


Gln Leu  Val Lys Ser Glu Leu  Glu Glu Lys Lys Ser  Glu Leu Arg 
    1250                 1255                 1260             


His Lys  Leu Lys Tyr Val Pro  His Glu Tyr Ile Glu  Leu Ile Glu 
    1265                 1270                 1275             


Ile Ala  Arg Asn Ser Thr Gln  Asp Arg Ile Leu Glu  Met Lys Val 
    1280                 1285                 1290             


Met Glu  Phe Phe Met Lys Val  Tyr Gly Tyr Arg Gly  Lys His Leu 
    1295                 1300                 1305             


Gly Gly  Ser Arg Lys Pro Asp  Gly Ala Ile Tyr Thr  Val Gly Ser 
    1310                 1315                 1320             


Pro Ile  Asp Tyr Gly Val Ile  Val Asp Thr Lys Ala  Tyr Ser Gly 
    1325                 1330                 1335             


Gly Tyr  Asn Leu Pro Ile Gly  Gln Ala Asp Glu Met  Gln Arg Tyr 
    1340                 1345                 1350             


Val Glu  Glu Asn Gln Thr Arg  Asn Lys His Ile Asn  Pro Asn Glu 
    1355                 1360                 1365             


Trp Trp  Lys Val Tyr Pro Ser  Ser Val Thr Glu Phe  Lys Phe Leu 
    1370                 1375                 1380             


Phe Val  Ser Gly His Phe Lys  Gly Asn Tyr Lys Ala  Gln Leu Thr 
    1385                 1390                 1395             


Arg Leu  Asn His Ile Thr Asn  Cys Asn Gly Ala Val  Leu Ser Val 
    1400                 1405                 1410             


Glu Glu  Leu Leu Ile Gly Gly  Glu Met Ile Lys Ala  Gly Thr Leu 
    1415                 1420                 1425             


Thr Leu  Glu Glu Val Arg Arg  Lys Phe Asn Asn Gly  Glu Ile Asn 
    1430                 1435                 1440             


Phe 
    


<210>  29
<211>  1440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  29

Met His Ile Gln Ser Leu Gln Gln Ser Pro Ser Phe Ala Val Glu Leu 
1               5                   10                  15      


His Gln Ala Ala Ser Gly Arg Leu Gly Gln Ile Glu Ala Arg Gln Val 
            20                  25                  30          


Ala Thr Pro Ser Glu Ala Gln Gln Leu Ala Gln Arg Gln Asp Ala Pro 
        35                  40                  45              


Lys Gly Glu Gly Leu Leu Asp Tyr Lys Asp Asp Asp Asp Lys Glu Leu 
    50                  55                  60                  


Met Asn Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
65                  70                  75                  80  


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
                85                  90                  95      


Met Lys Val Leu Gly Asn Thr Asp Lys His Phe Ile Lys Lys Asn Leu 
            100                 105                 110         


Leu Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Asp Arg Arg 
        115                 120                 125             


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
    130                 135                 140                 


Arg Tyr Leu Gln Glu Ile Phe Thr Glu Glu Met Ser Lys Val Asp Ile 
145                 150                 155                 160 


Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Val Pro Glu Asp Lys 
                165                 170                 175     


Arg Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Glu Glu Glu Lys Glu 
            180                 185                 190         


Tyr His Lys Asn Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala 
        195                 200                 205             


Asp Ser Lys Glu Lys Ala Asp Phe Arg Leu Ile Tyr Leu Ala Leu Ala 
    210                 215                 220                 


His Ile Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ser Phe Asp 
225                 230                 235                 240 


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Ser Ile 
                245                 250                 255     


Tyr Asp Asn Thr Phe Glu Gly Ser Ser Leu Asn Gly Gln Asn Ala Gln 
            260                 265                 270         


Val Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu 
        275                 280                 285             


Arg Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser 
    290                 295                 300                 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
305                 310                 315                 320 


Phe Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr 
                325                 330                 335     


Asp Glu Asp Leu Glu Asn Leu Leu Val Gln Ile Gly Asp Asp Phe Ala 
            340                 345                 350         


Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
        355                 360                 365             


Gly Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala 
    370                 375                 380                 


Ser Met Ile Asp Arg Tyr Glu Asn His Gln Lys Asp Leu Ala Ala Leu 
385                 390                 395                 400 


Lys Gln Phe Ile Lys Thr Asn Leu Pro Glu Lys Tyr Asp Glu Val Phe 
                405                 410                 415     


Ser Asp Gln Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 
            420                 425                 430         


Thr Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Leu 
        435                 440                 445             


Glu Gly Ala Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
    450                 455                 460                 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
465                 470                 475                 480 


Leu Gln Glu Met Asn Ala Ile Ile Arg Arg Gln Gly Glu His Tyr Pro 
                485                 490                 495     


Phe Leu Gln Glu Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
            500                 505                 510         


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala 
        515                 520                 525             


Trp Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu 
    530                 535                 540                 


Glu Ile Val Asp Lys Ala Arg Ser Ala Glu Asp Phe Ile Asn Lys Met 
545                 550                 555                 560 


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
                565                 570                 575     


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
            580                 585                 590         


Lys Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Gly 
        595                 600                 605             


Gln Lys Gln Gln Ile Val Thr Gln Leu Phe Lys Glu Lys Arg Lys Val 
    610                 615                 620                 


Thr Glu Lys Asp Ile Ile Gln Tyr Leu His Asn Val Asp Ser Tyr Asp 
625                 630                 635                 640 


Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
                645                 650                 655     


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Glu Phe Met Asp 
            660                 665                 670         


Asp Ser Lys Asn Glu Ala Ile Leu Glu Asn Ile Val His Thr Leu Thr 
        675                 680                 685             


Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala His Tyr Ala 
    690                 695                 700                 


Ser Ile Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg His Tyr 
705                 710                 715                 720 


Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Tyr Asp 
                725                 730                 735     


Lys Gln Ser Lys Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Glu 
            740                 745                 750         


Ile Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe 
        755                 760                 765             


Lys Glu Ile Ile Gln Lys Ala Gln Val Val Gly Lys Thr Asn Asp Val 
    770                 775                 780                 


Lys Gln Val Val Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly 
785                 790                 795                 800 


Ile Leu Gln Ser Ile Lys Leu Val Asp Glu Leu Val Lys Val Met Gly 
                805                 810                 815     


His Ala Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
            820                 825                 830         


Thr Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu 
        835                 840                 845             


Asp Ala Leu Lys Asn Leu Ala His Gly Leu Asp Ser Asn Ile Leu Lys 
    850                 855                 860                 


Glu His Pro Thr Asp Asn Ile Gln Leu Gln Asn Asp Arg Leu Phe Leu 
865                 870                 875                 880 


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Lys Ser Leu Asp 
                885                 890                 895     


Ile Asn Gln Leu Ser Ser Cys Asp Ile Asp His Ile Ile Pro Gln Ala 
            900                 905                 910         


Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Ser Lys 
        915                 920                 925             


Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Ile Val Gln 
    930                 935                 940                 


Lys Arg Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser 
945                 950                 955                 960 


Glu Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Asp 
                965                 970                 975     


Glu Arg Asp Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg 
            980                 985                 990         


Gln Ile Thr Lys His Val Ala Gln  Ile Leu Asp Ala Arg  Phe Asn Thr 
        995                 1000                 1005             


Glu Val  Thr Glu Lys Asp Lys  Lys Asp Arg Ser Val  Lys Ile Ile 
    1010                 1015                 1020             


Thr Leu  Lys Ser Asn Leu Val  Ser Asn Phe Arg Lys  Glu Phe Arg 
    1025                 1030                 1035             


Leu Tyr  Lys Val Arg Glu Ile  Asn Asp Tyr His His  Ala His Asp 
    1040                 1045                 1050             


Pro Tyr  Leu Asn Ala Val Val  Ala Lys Ala Ile Leu  Lys Lys Tyr 
    1055                 1060                 1065             


Pro Lys  Leu Glu Pro Glu Phe  Val Tyr Gly Asp Tyr  Gln Lys Tyr 
    1070                 1075                 1080             


Asp Leu  Lys Arg Tyr Ile Ser  Arg Thr Lys Asp Pro  Lys Glu Val 
    1085                 1090                 1095             


Glu Lys  Ala Thr Glu Lys Tyr  Phe Phe Tyr Ser Asn  Leu Leu Asn 
    1100                 1105                 1110             


Phe Phe  Lys Glu Glu Val His  Tyr Ala Asp Gly Thr  Ile Val Lys 
    1115                 1120                 1125             


Arg Glu  Asn Ile Glu Tyr Ser  Lys Asp Thr Gly Glu  Ile Ala Trp 
    1130                 1135                 1140             


Asn Lys  Glu Lys Asp Phe Ala  Thr Ile Lys Lys Val  Leu Ser Leu 
    1145                 1150                 1155             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Glu Gln  Thr Val Gly 
    1160                 1165                 1170             


Gln Asn  Gly Gly Leu Phe Asp  Asn Asn Ile Val Ser  Lys Lys Lys 
    1175                 1180                 1185             


Val Val  Asp Ala Ser Lys Leu  Thr Pro Ile Lys Ser  Gly Leu Ser 
    1190                 1195                 1200             


Pro Glu  Lys Tyr Gly Gly Tyr  Ala Arg Pro Thr Ile  Ala Tyr Ser 
    1205                 1210                 1215             


Val Leu  Val Ile Ala Asp Ile  Glu Lys Gly Lys Ala  Lys Lys Leu 
    1220                 1225                 1230             


Lys Arg  Ile Lys Glu Met Val  Gly Ile Thr Val Gln  Asp Lys Lys 
    1235                 1240                 1245             


Lys Phe  Glu Ala Asn Pro Ile  Ala Tyr Leu Glu Glu  Cys Gly Tyr 
    1250                 1255                 1260             


Lys Asn  Ile Asn Pro Asn Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1265                 1270                 1275             


Leu Phe  Glu Phe Asn Asn Gly  Gln Arg Arg Leu Leu  Ala Ser Ser 
    1280                 1285                 1290             


Ile Glu  Leu Gln Lys Gly Asn  Glu Leu Ile Val Pro  Tyr His Phe 
    1295                 1300                 1305             


Thr Ala  Leu Leu Tyr His Ala  Gln Arg Ile Asn Lys  Ile Ser Glu 
    1310                 1315                 1320             


Pro Ile  His Lys Gln Tyr Val  Glu Thr His Gln Ser  Glu Phe Lys 
    1325                 1330                 1335             


Glu Leu  Leu Thr Ala Ile Ile  Ser Leu Ser Lys Lys  Tyr Ile Gln 
    1340                 1345                 1350             


Lys Pro  Asn Val Glu Ser Leu  Leu Gln Gln Ala Phe  Asp Gln Ser 
    1355                 1360                 1365             


Asp Lys  Asp Ile Tyr Gln Leu  Ser Glu Ser Phe Ile  Ser Leu Leu 
    1370                 1375                 1380             


Lys Leu  Ile Ser Phe Gly Ala  Pro Gly Thr Phe Lys  Phe Leu Gly 
    1385                 1390                 1395             


Val Glu  Ile Ser Gln Ser Asn  Val Arg Tyr Gln Ser  Val Ser Ser 
    1400                 1405                 1410             


Cys Phe  Asn Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1415                 1420                 1425             


Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly Glu Asp  
    1430                 1435                 1440 


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  30
tctcactatg ggcacagcag                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  31
gggacagctt cagagcagac                                                   20


<210>  32
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  32
atcccgatgc agacgattca g                                                 21


<210>  33
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  33
aacagcacac aatctttgcc t                                                 21


<210>  34
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  34
actggcctta atcccaaaac g                                                 21


<210>  35
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  35
acggaccatt tgttatcagc aa                                                22


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  36
tcccgagacc cagttcatag                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  37
ttctttggca tcaaggaagg                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  38
gagaacccct acttccacgg                                                   20


<210>  39
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  39
gacagggcca tactgtagtc g                                                 21


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  40
acattttacc cgggagccta                                                   20


<210>  41
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  41
ggctttgtcc agctccact                                                    19


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  42
ccagctaaag gctgagagga                                                   20


<210>  43
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  43
aggcgtagtc gtatgggtt                                                    19


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  44
ttgctgacag gatgcagaag                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  45
gtacttgcgc tcaggaggag                                                   20


<210>  46
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  46
ctgttcaccg gggtggtgcc catcctggtc gagctggacg gcgacgtaaa cgg              53


<210>  47
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  47
ccgtttacgt cgccgtccag ctcgaccagg atgggcacca ccccggtgaa cag              53


<210>  48
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  48
ctgttcaccg gggtggtgcc catcctggtc gagctggacg gcgacgtaaa cggccacaag       60


<210>  49
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  49
ctgttcaccg gggtggtacg gcgacgtaaa cggccacaag                             40


<210>  50
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  50
ctgttcaccg gggtggtcgg ccacaag                                           27


<210>  51
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  51
ctgttcaccg gggtggtccc ggccacaag                                         29


<210>  52
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  52
ctgttcaccg gggtggtgcc ccatcctggt cgagctggac ggcgacgtaa acggccacaa       60

g                                                                       61


<210>  53
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  53
ctgttcaccg gggtggtgcc catcctggtc gagctggacg acgacgtaaa cggccacaag       60


<210>  54
<211>  83
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  54
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gtt                                               83


<210>  55
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  55
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt ctagctggac       60

ggcgacgtaa acggccacaa gttc                                              84


<210>  56
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  56
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttc                                              84


<210>  57
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  57
ctgtaggact gaacgtcttg ctcgagatgt gatgaaggag atgggaggcc atcacattgt       60

ag                                                                      62


<210>  58
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  58
ctacaatgtg atggcctccc atctccttca tcacatctcg agcaagacgt tcagtcctac       60

ag                                                                      62


<210>  59
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  59
gattttattt ctgtaggact gaacgtcttg ctcgagatgt gatgaaggag atgggaggcc       60

atcacattgt agccctc                                                      77


<210>  60
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  60
gattttattt ctgtaggact gaacgtcttg ctcgatcaca ttgtagccct c                51


<210>  61
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  61
gattttattt cttgggaggc catcacattg tagccctc                               38


<210>  62
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  62
gattttattt ctgtaggact gaacgtcttg cgggaggcca tcacattgta gccctc           56


<210>  63
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  63
gattttattt ctctgctgga gggaggccat cacattgtag ccctc                       45


<210>  64
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  64
gattttattt ctgtaggact gaacgtcttg ctctc                                  35


<210>  65
<211>  88
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  65
attaaattcc tgattttatt tctgtaggac tgaacgtctt gctcgagatg tgatgaagga       60

gatgggaggc catcacattg tagccctc                                          88


<210>  66
<211>  88
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  66
attaaattcc tgattttatt tctgtaggac tgaacgtctt gcttgagatg tgatgaagga       60

gatgggaggc catcacattg tagccctc                                          88


<210>  67
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  67
gattttattt ctgtaggact gaacgtcttg cttgagatgt gatgaaggag atgggaggcc       60

atcacattgt agccctc                                                      77


<210>  68
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  68
gattaaattc ctgattttat ttctgtagga ctgaacgtct tgctgccctc                  50


<210>  69
<211>  79
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  69
gattaaattc ctgattttat ttctgtagga ctgaacggat gtgatgaagg agatgggagg       60

ccatcacatt gtagccctc                                                    79


<210>  70
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  70
gattttattt ctgtaggact gaacgaggag atgggaggcc atcacattgt agccctc          57


