
                                SEQUENCE LISTING

<110> Aduro Biotech, Inc.

<120> EPIDERMAL GROWTH FACTOR RECEPTOR VARIANT
  III-MESOTHELIN FUSIONS AND METHODS OF USING THE SAME
  

<130> 5316.1000-003

<150> 62/146,559          
<151> 2015-04-13  

<150> 62/243,397          
<151> 2015-10-19  

<160> 32

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 2744
<212> DNA
<213> Artificial Sequence

<220> 
<223> fusion

<400> 1
gggaagcagt tggggttaac tgattaacaa atgttagaga aaaattaatt ctccaagtga 60
tattcttaaa ataattcatg aatatttttt cttatattag ctaattaaga agataattaa 120
ctgctaatcc aatttttaac ggaataaatt agtgaaaatg aaggccgaat tttccttgtt 180
ctaaaaaggt tgtattagcg tatcacgagg agggagtata agtgggatta aatagattta 240
tgcgtgcgat gatggtagtt ttcattactg ccaactgcat tacgattaac cccgacataa 300
tatttgcagc gacagatagc gaagattcca gtctaaacac agatgaatgg gaagaagaat 360
acgaaactgc acgtgaagta agttcacgtg atattgagga actagaaaaa tcgaataaag 420
tgaaaaatac gaacaaagca gaccaagata ataaacgtaa agcaaaagca gagaaaggtg 480
gatccgcaag caaagtattg ccagctagtc gtgcattaga ggagaaaaag gggaattacg 540
tggtgacgga tcatggatcg tgtgccgatg gctcagtaaa gactagtgcg agcaaagtgg 600
cccctgcatc acgagcactt gaagagaaaa aaggaaacta tgttgtgacc gatcatggta 660
gctgcggaga tggttcaatt aaattatcaa aagtcttacc agcatctaga gctttagagg 720
aaaagaaggg taactatgtc gtaacagatc atggaagttg tgctgacgga agtgttaaag 780
cgtcgaaagt agctccagct tctcgcgcat tagaagaaaa gaaaggcaat tatgttgtaa 840
cagaccatgg tagttgtggt gatggctcga tcaaattgtc aaaagttcta ccggcttctc 900
gtgcgctaga agagaagaaa ggaaattacg tagttacaga ccacggctct tgcgcggatg 960
gttccgttaa acaattgcgt acattagcag gtgaaacagg tcaagaagca gcaccacttg 1020
acggtgtatt aacgaatcca ccaaatatat caagtttaag tccacgtcaa ttattaggtt 1080
ttccatgtgc agaagtttca ggtttaagta cagaacgtgt ccgtgagtta gcagttgcat 1140
tagcacaaaa aaacgttaaa ttatctacag aacagttacg ttgtttagcc catagattaa 1200
gcgaaccacc agaagactta gatgcacttc ctttagacct tcttttattc ttaaatccag 1260
atgcattttc aggaccacaa gcatgtacac gtttttttag tcgaattaca aaagccaatg 1320
ttgatttatt acctcgtggg gctcctgaaa gacaacgttt attacctgct gcattagcat 1380
gctggggtgt tcgcggtagc ttattaagtg aagccgatgt tcgtgcttta gggggtttag 1440
catgtgattt acctggtcgt ttcgttgcag aatcagcaga agtgttatta ccgagattag 1500
tttcatgccc aggaccttta gatcaagatc aacaagaggc agctagagca gctcttcaag 1560
gaggaggccc accatatggc ccaccaagta catggagtgt ttctacaatg gatgcgttaa 1620
gaggtttatt accggtttta ggacaaccaa ttattcgtag tattccacaa ggcattgtag 1680
cagcatggcg tcaacgtagt tctcgtgatc cgtcttggcg acaaccagaa cgtacaattc 1740
tacgtccaag atttcgtaga gaagtagaaa aaacggcgtg tcctagtggc aaaaaagcac 1800
gtgaaattga tgaaagttta attttttata aaaaatggga attagaagca tgtgtcgatg 1860
cagcattact agctacacaa atggatcgtg ttaatgctat tccattcaca tatgaacaat 1920
tagatgtttt aaagcataaa ttagacgaat tatatccaca aggttatcca gaatcagtta 1980
ttcaacattt aggttactta tttttaaaaa tgagtccaga agacatacgc aaatggaatg 2040
ttacaagttt agaaacatta aaagcgcttt tagaagttaa caaaggtcat gaaatgagtc 2100
cacaagttgc tacgttaatt gatagattcg ttaaaggccg tggtcaatta gataaagata 2160
ctttagatac attaacagca ttttatcctg gctacttatg cagtttatca ccagaagaat 2220
taagttccgt tccaccgagt agtatctggg cagttcgtcc gcaagattta gatacatgcg 2280
acccacgtca attagatgtt ttatatccaa aagcaagatt agctttccaa aatatgaacg 2340
gtagtgaata tttcgtaaaa attcaatcct ttttaggtgg tgcaccaact gaagatctaa 2400
aagcattaag ccaacaaaat gtaagtatgg atttagctac gtttatgaaa ttacgtacag 2460
atgcagttct accattaaca gttgcagaag ttcaaaaatt attaggtcca cacgtagaag 2520
gattaaaagc agaagaacgt caccgtccag ttcgcgattg gattttacgt caacgtcaag 2580
atgatttaga tacattaggt ttaggtttac aaggcggtat tccgaatgga tatttagtgt 2640
tagatttatc ggttcaagaa gcattaagtg gtacaccgtg tttattaggt ccaggtccag 2700
ttttaacagt gttagcatta ttattagcca gtacattagc ttaa                  2744

<210> 2
<211> 221
<212> DNA
<213> Artificial Sequence

<220> 
<223> promoter

<400> 2
gggaagcagt tggggttaac tgattaacaa atgttagaga aaaattaatt ctccaagtga 60
tattcttaaa ataattcatg aatatttttt cttatattag ctaattaaga agataattaa 120
ctgctaatcc aatttttaac ggaataaatt agtgaaaatg aaggccgaat tttccttgtt 180
ctaaaaaggt tgtattagcg tatcacgagg agggagtata a                     221

<210> 3
<211> 258
<212> DNA
<213> Artificial Sequence

<220> 
<223> promoter

<400> 3
gtgggattaa atagatttat gcgtgcgatg atggtagttt tcattactgc caactgcatt 60
acgattaacc ccgacataat atttgcagcg acagatagcg aagattccag tctaaacaca 120
gatgaatggg aagaagaata cgaaactgca cgtgaagtaa gttcacgtga tattgaggaa 180
ctagaaaaat cgaataaagt gaaaaatacg aacaaagcag accaagataa taaacgtaaa 240
gcaaaagcag agaaaggt                                               258

<210> 4
<211> 63
<212> DNA
<213> Artificial Sequence

<220> 
<221> misc_feature   
<222> 33, 42
<223> n = A,T,C or G

<220> 
<223> EGFRvIII Consensus Sequence

<400> 4
ccdgcwwswm ghgcdytwga rgaraaraar ggnaaytayg tngtdacvga ycaygghwsb 60
tgy                                                               63

<210> 5
<211> 486
<212> DNA
<213> Artificial Sequence

<220> 
<223> fusion

<400> 5
gcaagcaaag tattgccagc tagtcgtgca ttagaggaga aaaaggggaa ttacgtggtg 60
acggatcatg gatcgtgtgc cgatggctca gtaaagacta gtgcgagcaa agtggcccct 120
gcatcacgag cacttgaaga gaaaaaagga aactatgttg tgaccgatca tggtagctgc 180
ggagatggtt caattaaatt atcaaaagtc ttaccagcat ctagagcttt agaggaaaag 240
aagggtaact atgtcgtaac agatcatgga agttgtgctg acggaagtgt taaagcgtcg 300
aaagtagctc cagcttctcg cgcattagaa gaaaagaaag gcaattatgt tgtaacagac 360
catggtagtt gtggtgatgg ctcgatcaaa ttgtcaaaag ttctaccggc ttctcgtgcg 420
ctagaagaga agaaaggaaa ttacgtagtt acagaccacg gctcttgcgc ggatggttcc 480
gttaaa                                                            486

<210> 6
<211> 1764
<212> DNA
<213> Artificial Sequence

<220> 
<223> fragment

<400> 6
cgtacattag caggtgaaac aggtcaagaa gcagcaccac ttgacggtgt attaacgaat 60
ccaccaaata tatcaagttt aagtccacgt caattattag gttttccatg tgcagaagtt 120
tcaggtttaa gtacagaacg tgtccgtgag ttagcagttg cattagcaca aaaaaacgtt 180
aaattatcta cagaacagtt acgttgttta gcccatagat taagcgaacc accagaagac 240
ttagatgcac ttcctttaga ccttctttta ttcttaaatc cagatgcatt ttcaggacca 300
caagcatgta cacgtttttt tagtcgaatt acaaaagcca atgttgattt attacctcgt 360
ggggctcctg aaagacaacg tttattacct gctgcattag catgctgggg tgttcgcggt 420
agcttattaa gtgaagccga tgttcgtgct ttagggggtt tagcatgtga tttacctggt 480
cgtttcgttg cagaatcagc agaagtgtta ttaccgagat tagtttcatg cccaggacct 540
ttagatcaag atcaacaaga ggcagctaga gcagctcttc aaggaggagg cccaccatat 600
ggcccaccaa gtacatggag tgtttctaca atggatgcgt taagaggttt attaccggtt 660
ttaggacaac caattattcg tagtattcca caaggcattg tagcagcatg gcgtcaacgt 720
agttctcgtg atccgtcttg gcgacaacca gaacgtacaa ttctacgtcc aagatttcgt 780
agagaagtag aaaaaacggc gtgtcctagt ggcaaaaaag cacgtgaaat tgatgaaagt 840
ttaatttttt ataaaaaatg ggaattagaa gcatgtgtcg atgcagcatt actagctaca 900
caaatggatc gtgttaatgc tattccattc acatatgaac aattagatgt tttaaagcat 960
aaattagacg aattatatcc acaaggttat ccagaatcag ttattcaaca tttaggttac 1020
ttatttttaa aaatgagtcc agaagacata cgcaaatgga atgttacaag tttagaaaca 1080
ttaaaagcgc ttttagaagt taacaaaggt catgaaatga gtccacaagt tgctacgtta 1140
attgatagat tcgttaaagg ccgtggtcaa ttagataaag atactttaga tacattaaca 1200
gcattttatc ctggctactt atgcagttta tcaccagaag aattaagttc cgttccaccg 1260
agtagtatct gggcagttcg tccgcaagat ttagatacat gcgacccacg tcaattagat 1320
gttttatatc caaaagcaag attagctttc caaaatatga acggtagtga atatttcgta 1380
aaaattcaat cctttttagg tggtgcacca actgaagatc taaaagcatt aagccaacaa 1440
aatgtaagta tggatttagc tacgtttatg aaattacgta cagatgcagt tctaccatta 1500
acagttgcag aagttcaaaa attattaggt ccacacgtag aaggattaaa agcagaagaa 1560
cgtcaccgtc cagttcgcga ttggatttta cgtcaacgtc aagatgattt agatacatta 1620
ggtttaggtt tacaaggcgg tattccgaat ggatatttag tgttagattt atcggttcaa 1680
gaagcattaa gtggtacacc gtgtttatta ggtccaggtc cagttttaac agtgttagca 1740
ttattattag ccagtacatt agct                                        1764

<210> 7
<211> 2256
<212> DNA
<213> Artificial Sequence

<220> 
<223> fragment

<400> 7
gcaagcaaag tattgccagc tagtcgtgca ttagaggaga aaaaggggaa ttacgtggtg 60
acggatcatg gatcgtgtgc cgatggctca gtaaagacta gtgcgagcaa agtggcccct 120
gcatcacgag cacttgaaga gaaaaaagga aactatgttg tgaccgatca tggtagctgc 180
ggagatggtt caattaaatt atcaaaagtc ttaccagcat ctagagcttt agaggaaaag 240
aagggtaact atgtcgtaac agatcatgga agttgtgctg acggaagtgt taaagcgtcg 300
aaagtagctc cagcttctcg cgcattagaa gaaaagaaag gcaattatgt tgtaacagac 360
catggtagtt gtggtgatgg ctcgatcaaa ttgtcaaaag ttctaccggc ttctcgtgcg 420
ctagaagaga agaaaggaaa ttacgtagtt acagaccacg gctcttgcgc ggatggttcc 480
gttaaacaat tgcgtacatt agcaggtgaa acaggtcaag aagcagcacc acttgacggt 540
gtattaacga atccaccaaa tatatcaagt ttaagtccac gtcaattatt aggttttcca 600
tgtgcagaag tttcaggttt aagtacagaa cgtgtccgtg agttagcagt tgcattagca 660
caaaaaaacg ttaaattatc tacagaacag ttacgttgtt tagcccatag attaagcgaa 720
ccaccagaag acttagatgc acttccttta gaccttcttt tattcttaaa tccagatgca 780
ttttcaggac cacaagcatg tacacgtttt tttagtcgaa ttacaaaagc caatgttgat 840
ttattacctc gtggggctcc tgaaagacaa cgtttattac ctgctgcatt agcatgctgg 900
ggtgttcgcg gtagcttatt aagtgaagcc gatgttcgtg ctttaggggg tttagcatgt 960
gatttacctg gtcgtttcgt tgcagaatca gcagaagtgt tattaccgag attagtttca 1020
tgcccaggac ctttagatca agatcaacaa gaggcagcta gagcagctct tcaaggagga 1080
ggcccaccat atggcccacc aagtacatgg agtgtttcta caatggatgc gttaagaggt 1140
ttattaccgg ttttaggaca accaattatt cgtagtattc cacaaggcat tgtagcagca 1200
tggcgtcaac gtagttctcg tgatccgtct tggcgacaac cagaacgtac aattctacgt 1260
ccaagatttc gtagagaagt agaaaaaacg gcgtgtccta gtggcaaaaa agcacgtgaa 1320
attgatgaaa gtttaatttt ttataaaaaa tgggaattag aagcatgtgt cgatgcagca 1380
ttactagcta cacaaatgga tcgtgttaat gctattccat tcacatatga acaattagat 1440
gttttaaagc ataaattaga cgaattatat ccacaaggtt atccagaatc agttattcaa 1500
catttaggtt acttattttt aaaaatgagt ccagaagaca tacgcaaatg gaatgttaca 1560
agtttagaaa cattaaaagc gcttttagaa gttaacaaag gtcatgaaat gagtccacaa 1620
gttgctacgt taattgatag attcgttaaa ggccgtggtc aattagataa agatacttta 1680
gatacattaa cagcatttta tcctggctac ttatgcagtt tatcaccaga agaattaagt 1740
tccgttccac cgagtagtat ctgggcagtt cgtccgcaag atttagatac atgcgaccca 1800
cgtcaattag atgttttata tccaaaagca agattagctt tccaaaatat gaacggtagt 1860
gaatatttcg taaaaattca atccttttta ggtggtgcac caactgaaga tctaaaagca 1920
ttaagccaac aaaatgtaag tatggattta gctacgttta tgaaattacg tacagatgca 1980
gttctaccat taacagttgc agaagttcaa aaattattag gtccacacgt agaaggatta 2040
aaagcagaag aacgtcaccg tccagttcgc gattggattt tacgtcaacg tcaagatgat 2100
ttagatacat taggtttagg tttacaaggc ggtattccga atggatattt agtgttagat 2160
ttatcggttc aagaagcatt aagtggtaca ccgtgtttat taggtccagg tccagtttta 2220
acagtgttag cattattatt agccagtaca ttagct                           2256

<210> 8
<211> 840
<212> PRT
<213> Artificial Sequence

<220> 
<223> fusion

<400> 8
Met Gly Leu Asn Arg Phe Met Arg Ala Met Met Val Val Phe Ile Thr
 1               5                  10                  15      
Ala Asn Cys Ile Thr Ile Asn Pro Asp Ile Ile Phe Ala Ala Thr Asp
            20                  25                  30          
Ser Glu Asp Ser Ser Leu Asn Thr Asp Glu Trp Glu Glu Glu Tyr Glu
        35                  40                  45              
Thr Ala Arg Glu Val Ser Ser Arg Asp Ile Glu Glu Leu Glu Lys Ser
    50                  55                  60                  
Asn Lys Val Lys Asn Thr Asn Lys Ala Asp Gln Asp Asn Lys Arg Lys
65                  70                  75                  80  
Ala Lys Ala Glu Lys Gly Gly Ser Ala Ser Lys Val Leu Pro Ala Ser
                85                  90                  95      
Arg Ala Leu Glu Glu Lys Lys Gly Asn Tyr Val Val Thr Asp His Gly
            100                 105                 110         
Ser Cys Ala Asp Gly Ser Val Lys Thr Ser Ala Ser Lys Val Ala Pro
        115                 120                 125             
Ala Ser Arg Ala Leu Glu Glu Lys Lys Gly Asn Tyr Val Val Thr Asp
    130                 135                 140                 
His Gly Ser Cys Gly Asp Gly Ser Ile Lys Leu Ser Lys Val Leu Pro
145                 150                 155                 160 
Ala Ser Arg Ala Leu Glu Glu Lys Lys Gly Asn Tyr Val Val Thr Asp
                165                 170                 175     
His Gly Ser Cys Ala Asp Gly Ser Val Lys Ala Ser Lys Val Ala Pro
            180                 185                 190         
Ala Ser Arg Ala Leu Glu Glu Lys Lys Gly Asn Tyr Val Val Thr Asp
        195                 200                 205             
His Gly Ser Cys Gly Asp Gly Ser Ile Lys Leu Ser Lys Val Leu Pro
    210                 215                 220                 
Ala Ser Arg Ala Leu Glu Glu Lys Lys Gly Asn Tyr Val Val Thr Asp
225                 230                 235                 240 
His Gly Ser Cys Ala Asp Gly Ser Val Lys Gln Leu Arg Thr Leu Ala
                245                 250                 255     
Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu Asp Gly Val Leu Thr Asn
            260                 265                 270         
Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg Gln Leu Leu Gly Phe Pro
        275                 280                 285             
Cys Ala Glu Val Ser Gly Leu Ser Thr Glu Arg Val Arg Glu Leu Ala
    290                 295                 300                 
Val Ala Leu Ala Gln Lys Asn Val Lys Leu Ser Thr Glu Gln Leu Arg
305                 310                 315                 320 
Cys Leu Ala His Arg Leu Ser Glu Pro Pro Glu Asp Leu Asp Ala Leu
                325                 330                 335     
Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro Asp Ala Phe Ser Gly Pro
            340                 345                 350         
Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile Thr Lys Ala Asn Val Asp
        355                 360                 365             
Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln Arg Leu Leu Pro Ala Ala
    370                 375                 380                 
Leu Ala Cys Trp Gly Val Arg Gly Ser Leu Leu Ser Glu Ala Asp Val
385                 390                 395                 400 
Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu Pro Gly Arg Phe Val Ala
                405                 410                 415     
Glu Ser Ala Glu Val Leu Leu Pro Arg Leu Val Ser Cys Pro Gly Pro
            420                 425                 430         
Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg Ala Ala Leu Gln Gly Gly
        435                 440                 445             
Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp Ser Val Ser Thr Met Asp
    450                 455                 460                 
Ala Leu Arg Gly Leu Leu Pro Val Leu Gly Gln Pro Ile Ile Arg Ser
465                 470                 475                 480 
Ile Pro Gln Gly Ile Val Ala Ala Trp Arg Gln Arg Ser Ser Arg Asp
                485                 490                 495     
Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile Leu Arg Pro Arg Phe Arg
            500                 505                 510         
Arg Glu Val Glu Lys Thr Ala Cys Pro Ser Gly Lys Lys Ala Arg Glu
        515                 520                 525             
Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys Trp Glu Leu Glu Ala Cys
    530                 535                 540                 
Val Asp Ala Ala Leu Leu Ala Thr Gln Met Asp Arg Val Asn Ala Ile
545                 550                 555                 560 
Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu Lys His Lys Leu Asp Glu
                565                 570                 575     
Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val Ile Gln His Leu Gly Tyr
            580                 585                 590         
Leu Phe Leu Lys Met Ser Pro Glu Asp Ile Arg Lys Trp Asn Val Thr
        595                 600                 605             
Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu Val Asn Lys Gly His Glu
    610                 615                 620                 
Met Ser Pro Gln Val Ala Thr Leu Ile Asp Arg Phe Val Lys Gly Arg
625                 630                 635                 640 
Gly Gln Leu Asp Lys Asp Thr Leu Asp Thr Leu Thr Ala Phe Tyr Pro
                645                 650                 655     
Gly Tyr Leu Cys Ser Leu Ser Pro Glu Glu Leu Ser Ser Val Pro Pro
            660                 665                 670         
Ser Ser Ile Trp Ala Val Arg Pro Gln Asp Leu Asp Thr Cys Asp Pro
        675                 680                 685             
Arg Gln Leu Asp Val Leu Tyr Pro Lys Ala Arg Leu Ala Phe Gln Asn
    690                 695                 700                 
Met Asn Gly Ser Glu Tyr Phe Val Lys Ile Gln Ser Phe Leu Gly Gly
705                 710                 715                 720 
Ala Pro Thr Glu Asp Leu Lys Ala Leu Ser Gln Gln Asn Val Ser Met
                725                 730                 735     
Asp Leu Ala Thr Phe Met Lys Leu Arg Thr Asp Ala Val Leu Pro Leu
            740                 745                 750         
Thr Val Ala Glu Val Gln Lys Leu Leu Gly Pro His Val Glu Gly Leu
        755                 760                 765             
Lys Ala Glu Glu Arg His Arg Pro Val Arg Asp Trp Ile Leu Arg Gln
    770                 775                 780                 
Arg Gln Asp Asp Leu Asp Thr Leu Gly Leu Gly Leu Gln Gly Gly Ile
785                 790                 795                 800 
Pro Asn Gly Tyr Leu Val Leu Asp Leu Ser Val Gln Glu Ala Leu Ser
                805                 810                 815     
Gly Thr Pro Cys Leu Leu Gly Pro Gly Pro Val Leu Thr Val Leu Ala
            820                 825                 830         
Leu Leu Leu Ala Ser Thr Leu Ala
        835                 840 


<210> 9
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> fragment

<400> 9
Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Gly Asn Tyr Val Val Thr
 1               5                  10                  15      
Asp His Gly Ser Cys
            20      


<210> 10
<211> 162
<212> PRT
<213> Artificial Sequence

<220> 
<223> fragment

<400> 10
Ala Ser Lys Val Leu Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Gly
 1               5                  10                  15      
Asn Tyr Val Val Thr Asp His Gly Ser Cys Ala Asp Gly Ser Val Lys
            20                  25                  30          
Thr Ser Ala Ser Lys Val Ala Pro Ala Ser Arg Ala Leu Glu Glu Lys
        35                  40                  45              
Lys Gly Asn Tyr Val Val Thr Asp His Gly Ser Cys Gly Asp Gly Ser
    50                  55                  60                  
Ile Lys Leu Ser Lys Val Leu Pro Ala Ser Arg Ala Leu Glu Glu Lys
65                  70                  75                  80  
Lys Gly Asn Tyr Val Val Thr Asp His Gly Ser Cys Ala Asp Gly Ser
                85                  90                  95      
Val Lys Ala Ser Lys Val Ala Pro Ala Ser Arg Ala Leu Glu Glu Lys
            100                 105                 110         
Lys Gly Asn Tyr Val Val Thr Asp His Gly Ser Cys Gly Asp Gly Ser
        115                 120                 125             
Ile Lys Leu Ser Lys Val Leu Pro Ala Ser Arg Ala Leu Glu Glu Lys
    130                 135                 140                 
Lys Gly Asn Tyr Val Val Thr Asp His Gly Ser Cys Ala Asp Gly Ser
145                 150                 155                 160 
Val Lys
        


<210> 11
<211> 588
<212> PRT
<213> Artificial Sequence

<220> 
<223> fragment

<400> 11
Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu Asp Gly
 1               5                  10                  15      
Val Leu Thr Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg Gln Leu
            20                  25                  30          
Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu Arg Val
        35                  40                  45              
Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu Ser Thr
    50                  55                  60                  
Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro Glu Asp
65                  70                  75                  80  
Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro Asp Ala
                85                  90                  95      
Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile Thr Lys
            100                 105                 110         
Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln Arg Leu
        115                 120                 125             
Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu Leu Ser
    130                 135                 140                 
Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu Pro Gly
145                 150                 155                 160 
Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu Val Ser
                165                 170                 175     
Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg Ala Ala
            180                 185                 190         
Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp Ser Val
        195                 200                 205             
Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly Gln Pro
    210                 215                 220                 
Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg Gln Arg
225                 230                 235                 240 
Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile Leu Arg
                245                 250                 255     
Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser Gly Lys
            260                 265                 270         
Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys Trp Glu
        275                 280                 285             
Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met Asp Arg
    290                 295                 300                 
Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu Lys His
305                 310                 315                 320 
Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val Ile Gln
                325                 330                 335     
His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile Arg Lys
            340                 345                 350         
Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu Val Asn
        355                 360                 365             
Lys Gly His Glu Met Ser Pro Gln Val Ala Thr Leu Ile Asp Arg Phe
    370                 375                 380                 
Val Lys Gly Arg Gly Gln Leu Asp Lys Asp Thr Leu Asp Thr Leu Thr
385                 390                 395                 400 
Ala Phe Tyr Pro Gly Tyr Leu Cys Ser Leu Ser Pro Glu Glu Leu Ser
                405                 410                 415     
Ser Val Pro Pro Ser Ser Ile Trp Ala Val Arg Pro Gln Asp Leu Asp
            420                 425                 430         
Thr Cys Asp Pro Arg Gln Leu Asp Val Leu Tyr Pro Lys Ala Arg Leu
        435                 440                 445             
Ala Phe Gln Asn Met Asn Gly Ser Glu Tyr Phe Val Lys Ile Gln Ser
    450                 455                 460                 
Phe Leu Gly Gly Ala Pro Thr Glu Asp Leu Lys Ala Leu Ser Gln Gln
465                 470                 475                 480 
Asn Val Ser Met Asp Leu Ala Thr Phe Met Lys Leu Arg Thr Asp Ala
                485                 490                 495     
Val Leu Pro Leu Thr Val Ala Glu Val Gln Lys Leu Leu Gly Pro His
            500                 505                 510         
Val Glu Gly Leu Lys Ala Glu Glu Arg His Arg Pro Val Arg Asp Trp
        515                 520                 525             
Ile Leu Arg Gln Arg Gln Asp Asp Leu Asp Thr Leu Gly Leu Gly Leu
    530                 535                 540                 
Gln Gly Gly Ile Pro Asn Gly Tyr Leu Val Leu Asp Leu Ser Val Gln
545                 550                 555                 560 
Glu Ala Leu Ser Gly Thr Pro Cys Leu Leu Gly Pro Gly Pro Val Leu
                565                 570                 575     
Thr Val Leu Ala Leu Leu Leu Ala Ser Thr Leu Ala
            580                 585             


<210> 12
<211> 88
<212> PRT
<213> Artificial Sequence

<220> 
<223> fusion

<400> 12
Met Gly Leu Asn Arg Phe Met Arg Ala Met Met Val Val Phe Ile Thr
 1               5                  10                  15      
Ala Asn Cys Ile Thr Ile Asn Pro Asp Ile Ile Phe Ala Ala Thr Asp
            20                  25                  30          
Ser Glu Asp Ser Ser Leu Asn Thr Asp Glu Trp Glu Glu Glu Tyr Glu
        35                  40                  45              
Thr Ala Arg Glu Val Ser Ser Arg Asp Ile Glu Glu Leu Glu Lys Ser
    50                  55                  60                  
Asn Lys Val Lys Asn Thr Asn Lys Ala Asp Gln Asp Asn Lys Arg Lys
65                  70                  75                  80  
Ala Lys Ala Glu Lys Gly Gly Ser
                85              


<210> 13
<211> 63
<212> DNA
<213> Artificial Sequence

<220> 
<223> fragment

<400> 13
ccagctagtc gtgcattaga ggagaaaaag gggaattacg tggtgacgga tcatggatcg 60
tgt                                                               63

<210> 14
<211> 63
<212> DNA
<213> Artificial Sequence

<220> 
<223> fragment

<400> 14
cctgcatcac gagcacttga agagaaaaaa ggaaactatg ttgtgaccga tcatggtagc 60
tgc                                                               63

<210> 15
<211> 63
<212> DNA
<213> Artificial Sequence

<220> 
<223> fragment

<400> 15
ccagcatcta gagctttaga ggaaaagaag ggtaactatg tcgtaacaga tcatggaagt 60
tgt                                                               63

<210> 16
<211> 63
<212> DNA
<213> Artificial Sequence

<220> 
<223> fragment

<400> 16
ccagcttctc gcgcattaga agaaaagaaa ggcaattatg ttgtaacaga ccatggtagt 60
tgt                                                               63

<210> 17
<211> 63
<212> DNA
<213> Artificial Sequence

<220> 
<223> fragment

<400> 17
ccggcttctc gtgcgctaga agagaagaaa ggaaattacg tagttacaga ccacggctct 60
tgc                                                               63

<210> 18
<211> 231
<212> DNA
<213> Artificial Sequence

<220> 
<223> promoter

<400> 18
tcctttgatt agtatattcc tatcttaaag ttacttttat gtggaggcat taacatttgt 60
taatgacgtc aaaaggatag caagactaga ataaagctat aaagcaagca tataatattg 120
cgtttcatct ttagaagcga atttcgccaa tattataatt atcaaaagag aggggtggca 180
aacggtattt ggcattatta ggttaaaaaa tgtagaagga gagtgaaacc c          231

<210> 19
<211> 1323
<212> DNA
<213> Artificial Sequence

<220> 
<223> LLO441 sequence

<400> 19
atgaaaaaaa taatgctagt ttttattaca cttatattag ttagtctacc aattgcgcaa 60
caaactgaag caaaggatgc atctgcattc aataaagaaa attcaatttc atccatggca 120
ccaccagcat ctccgcctgc aagtcctaag acgccaatcg aaaagaaaca cgcggatgaa 180
atcgataagt atatacaagg attggattac aataaaaaca atgtattagt ataccacgga 240
gatgcagtga caaatgtgcc gccaagaaaa ggttacaaag atggaaatga atatattgtt 300
gtggagaaaa agaagaaatc catcaatcaa aataatgcag acattcaagt tgtgaatgca 360
atttcgagcc taacctatcc aggtgctctc gtaaaagcga attcggaatt agtagaaaat 420
caaccagatg ttctccctgt aaaacgtgat tcattaacac tcagcattga tttgccaggt 480
atgactaatc aagacaataa aatagttgta aaaaatgcca ctaaatcaaa cgttaacaac 540
gcagtaaata cattagtgga aagatggaat gaaaaatatg ctcaagctta tccaaatgta 600
agtgcaaaaa ttgattatga tgacgaaatg gcttacagtg aatcacaatt aattgcgaaa 660
tttggtacag catttaaagc tgtaaataat agcttgaatg taaacttcgg cgcaatcagt 720
gaagggaaaa tgcaagaaga agtcattagt tttaaacaaa tttactataa cgtgaatgtt 780
aatgaaccta caagaccttc cagatttttc ggcaaagctg ttactaaaga gcagttgcaa 840
gcgcttggag tgaatgcaga aaatcctcct gcatatatct caagtgtggc gtatggccgt 900
caagtttatt tgaaattatc aactaattcc catagtacta aagtaaaagc tgcttttgat 960
gctgccgtaa gcggaaaatc tgtctcaggt gatgtagaac taacaaatat catcaaaaat 1020
tcttccttca aagccgtaat ttacggaggt tccgcaaaag atgaagttca aatcatcgac 1080
ggcaacctcg gagacttacg cgatattttg aaaaaaggcg ctacttttaa tcgagaaaca 1140
ccaggagttc ccattgctta tacaacaaac ttcctaaaag acaatgaatt agctgttatt 1200
aaaaacaact cagaatatat tgaaacaact tcaaaagctt atacagatgg aaaaattaac 1260
atcgatcact ctggaggata cgttgctcaa ttcaacattt cttgggatga agtaaattat 1320
gat                                                               1323

<210> 20
<211> 441
<212> PRT
<213> Artificial Sequence

<220> 
<223> LLO441 sequence

<400> 20
Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu
 1               5                  10                  15      
Pro Ile Ala Gln Gln Thr Glu Ala Lys Asp Ala Ser Ala Phe Asn Lys
            20                  25                  30          
Glu Asn Ser Ile Ser Ser Met Ala Pro Pro Ala Ser Pro Pro Ala Ser
        35                  40                  45              
Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys Tyr
    50                  55                  60                  
Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn Val Leu Val Tyr His Gly
65                  70                  75                  80  
Asp Ala Val Thr Asn Val Pro Pro Arg Lys Gly Tyr Lys Asp Gly Asn
                85                  90                  95      
Glu Tyr Ile Val Val Glu Lys Lys Lys Lys Ser Ile Asn Gln Asn Asn
            100                 105                 110         
Ala Asp Ile Gln Val Val Asn Ala Ile Ser Ser Leu Thr Tyr Pro Gly
        115                 120                 125             
Ala Leu Val Lys Ala Asn Ser Glu Leu Val Glu Asn Gln Pro Asp Val
    130                 135                 140                 
Leu Pro Val Lys Arg Asp Ser Leu Thr Leu Ser Ile Asp Leu Pro Gly
145                 150                 155                 160 
Met Thr Asn Gln Asp Asn Lys Ile Val Val Lys Asn Ala Thr Lys Ser
                165                 170                 175     
Asn Val Asn Asn Ala Val Asn Thr Leu Val Glu Arg Trp Asn Glu Lys
            180                 185                 190         
Tyr Ala Gln Ala Tyr Pro Asn Val Ser Ala Lys Ile Asp Tyr Asp Asp
        195                 200                 205             
Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile Ala Lys Phe Gly Thr Ala
    210                 215                 220                 
Phe Lys Ala Val Asn Asn Ser Leu Asn Val Asn Phe Gly Ala Ile Ser
225                 230                 235                 240 
Glu Gly Lys Met Gln Glu Glu Val Ile Ser Phe Lys Gln Ile Tyr Tyr
                245                 250                 255     
Asn Val Asn Val Asn Glu Pro Thr Arg Pro Ser Arg Phe Phe Gly Lys
            260                 265                 270         
Ala Val Thr Lys Glu Gln Leu Gln Ala Leu Gly Val Asn Ala Glu Asn
        275                 280                 285             
Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu
    290                 295                 300                 
Lys Leu Ser Thr Asn Ser His Ser Thr Lys Val Lys Ala Ala Phe Asp
305                 310                 315                 320 
Ala Ala Val Ser Gly Lys Ser Val Ser Gly Asp Val Glu Leu Thr Asn
                325                 330                 335     
Ile Ile Lys Asn Ser Ser Phe Lys Ala Val Ile Tyr Gly Gly Ser Ala
            340                 345                 350         
Lys Asp Glu Val Gln Ile Ile Asp Gly Asn Leu Gly Asp Leu Arg Asp
        355                 360                 365             
Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg Glu Thr Pro Gly Val Pro
    370                 375                 380                 
Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp Asn Glu Leu Ala Val Ile
385                 390                 395                 400 
Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr Ser Lys Ala Tyr Thr Asp
                405                 410                 415     
Gly Lys Ile Asn Ile Asp His Ser Gly Gly Tyr Val Ala Gln Phe Asn
            420                 425                 430         
Ile Ser Trp Asp Glu Val Asn Tyr Asp
        435                 440     


<210> 21
<211> 1266
<212> DNA
<213> Artificial Sequence

<220> 
<223> fragment

<400> 21
atgaaaaaaa taatgctagt ttttattaca cttatattag ttagtctacc aattgcgcaa 60
caaactgaag caaaggatgc atctgcattc aatacgccaa tcgaaaagaa acacgcggat 120
gaaatcgata agtatataca aggattggat tacaataaaa acaatgtatt agtataccac 180
ggagatgcag tgacaaatgt gccgccaaga aaaggttaca aagatggaaa tgaatatatt 240
gttgtggaga aaaagaagaa atccatcaat caaaataatg cagacattca agttgtgaat 300
gcaatttcga gcctaaccta tccaggtgct ctcgtaaaag cgaattcgga attagtagaa 360
aatcaaccag atgttctccc tgtaaaacgt gattcattaa cactcagcat tgatttgcca 420
ggtatgacta atcaagacaa taaaatagtt gtaaaaaatg ccactaaatc aaacgttaac 480
aacgcagtaa atacattagt ggaaagatgg aatgaaaaat atgctcaagc ttatccaaat 540
gtaagtgcaa aaattgatta tgatgacgaa atggcttaca gtgaatcaca attaattgcg 600
aaatttggta cagcatttaa agctgtaaat aatagcttga atgtaaactt cggcgcaatc 660
agtgaaggga aaatgcaaga agaagtcatt agttttaaac aaatttacta taacgtgaat 720
gttaatgaac ctacaagacc ttccagattt ttcggcaaag ctgttactaa agagcagttg 780
caagcgcttg gagtgaatgc agaaaatcct cctgcatata tctcaagtgt ggcgtatggc 840
cgtcaagttt atttgaaatt atcaactaat tcccatagta ctaaagtaaa agctgctttt 900
gatgctgccg taagcggaaa atctgtctca ggtgatgtag aactaacaaa tatcatcaaa 960
aattcttcct tcaaagccgt aatttacgga ggttccgcaa aagatgaagt tcaaatcatc 1020
gacggcaacc tcggagactt acgcgatatt ttgaaaaaag gcgctacttt taatcgagaa 1080
acaccaggag ttcccattgc ttatacaaca aacttcctaa aagacaatga attagctgtt 1140
attaaaaaca actcagaata tattgaaaca acttcaaaag cttatacaga tggaaaaatt 1200
aacatcgatc actctggagg atacgttgct caattcaaca tttcttggga tgaagtaaat 1260
tatgat                                                            1266

<210> 22
<211> 422
<212> PRT
<213> Artificial Sequence

<220> 
<223> fragment

<400> 22
Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu
 1               5                  10                  15      
Pro Ile Ala Gln Gln Thr Glu Ala Lys Asp Ala Ser Ala Phe Asn Thr
            20                  25                  30          
Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys Tyr Ile Gln Gly
        35                  40                  45              
Leu Asp Tyr Asn Lys Asn Asn Val Leu Val Tyr His Gly Asp Ala Val
    50                  55                  60                  
Thr Asn Val Pro Pro Arg Lys Gly Tyr Lys Asp Gly Asn Glu Tyr Ile
65                  70                  75                  80  
Val Val Glu Lys Lys Lys Lys Ser Ile Asn Gln Asn Asn Ala Asp Ile
                85                  90                  95      
Gln Val Val Asn Ala Ile Ser Ser Leu Thr Tyr Pro Gly Ala Leu Val
            100                 105                 110         
Lys Ala Asn Ser Glu Leu Val Glu Asn Gln Pro Asp Val Leu Pro Val
        115                 120                 125             
Lys Arg Asp Ser Leu Thr Leu Ser Ile Asp Leu Pro Gly Met Thr Asn
    130                 135                 140                 
Gln Asp Asn Lys Ile Val Val Lys Asn Ala Thr Lys Ser Asn Val Asn
145                 150                 155                 160 
Asn Ala Val Asn Thr Leu Val Glu Arg Trp Asn Glu Lys Tyr Ala Gln
                165                 170                 175     
Ala Tyr Pro Asn Val Ser Ala Lys Ile Asp Tyr Asp Asp Glu Met Ala
            180                 185                 190         
Tyr Ser Glu Ser Gln Leu Ile Ala Lys Phe Gly Thr Ala Phe Lys Ala
        195                 200                 205             
Val Asn Asn Ser Leu Asn Val Asn Phe Gly Ala Ile Ser Glu Gly Lys
    210                 215                 220                 
Met Gln Glu Glu Val Ile Ser Phe Lys Gln Ile Tyr Tyr Asn Val Asn
225                 230                 235                 240 
Val Asn Glu Pro Thr Arg Pro Ser Arg Phe Phe Gly Lys Ala Val Thr
                245                 250                 255     
Lys Glu Gln Leu Gln Ala Leu Gly Val Asn Ala Glu Asn Pro Pro Ala
            260                 265                 270         
Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Ser
        275                 280                 285             
Thr Asn Ser His Ser Thr Lys Val Lys Ala Ala Phe Asp Ala Ala Val
    290                 295                 300                 
Ser Gly Lys Ser Val Ser Gly Asp Val Glu Leu Thr Asn Ile Ile Lys
305                 310                 315                 320 
Asn Ser Ser Phe Lys Ala Val Ile Tyr Gly Gly Ser Ala Lys Asp Glu
                325                 330                 335     
Val Gln Ile Ile Asp Gly Asn Leu Gly Asp Leu Arg Asp Ile Leu Lys
            340                 345                 350         
Lys Gly Ala Thr Phe Asn Arg Glu Thr Pro Gly Val Pro Ile Ala Tyr
        355                 360                 365             
Thr Thr Asn Phe Leu Lys Asp Asn Glu Leu Ala Val Ile Lys Asn Asn
    370                 375                 380                 
Ser Glu Tyr Ile Glu Thr Thr Ser Lys Ala Tyr Thr Asp Gly Lys Ile
385                 390                 395                 400 
Asn Ile Asp His Ser Gly Gly Tyr Val Ala Gln Phe Asn Ile Ser Trp
                405                 410                 415     
Asp Glu Val Asn Tyr Asp
            420         


<210> 23
<211> 1245
<212> DNA
<213> Artificial Sequence

<220> 
<223> fragment

<400> 23
atgaaaaaaa taatgctagt ttttattaca cttatattag ttagtctacc aattgcgcaa 60
caaactgaag caaaggatgc atctgcattc aataaagaag aaatcgataa gtatatacaa 120
ggattggatt acaataaaaa caatgtatta gtataccacg gagatgcagt gacaaatgtg 180
ccgccaagaa aaggttacaa agatggaaat gaatatattg ttgtggagaa aaagaagaaa 240
tccatcaatc aaaataatgc agacattcaa gttgtgaatg caatttcgag cctaacctat 300
ccaggtgctc tcgtaaaagc gaattcggaa ttagtagaaa atcaaccaga tgttctccct 360
gtaaaacgtg attcattaac actcagcatt gatttgccag gtatgactaa tcaagacaat 420
aaaatagttg taaaaaatgc cactaaatca aacgttaaca acgcagtaaa tacattagtg 480
gaaagatgga atgaaaaata tgctcaagct tatccaaatg taagtgcaaa aattgattat 540
gatgacgaaa tggcttacag tgaatcacaa ttaattgcga aatttggtac agcatttaaa 600
gctgtaaata atagcttgaa tgtaaacttc ggcgcaatca gtgaagggaa aatgcaagaa 660
gaagtcatta gttttaaaca aatttactat aacgtgaatg ttaatgaacc tacaagacct 720
tccagatttt tcggcaaagc tgttactaaa gagcagttgc aagcgcttgg agtgaatgca 780
gaaaatcctc ctgcatatat ctcaagtgtg gcgtatggcc gtcaagttta tttgaaatta 840
tcaactaatt cccatagtac taaagtaaaa gctgcttttg atgctgccgt aagcggaaaa 900
tctgtctcag gtgatgtaga actaacaaat atcatcaaaa attcttcctt caaagccgta 960
atttacggag gttccgcaaa agatgaagtt caaatcatcg acggcaacct cggagactta 1020
cgcgatattt tgaaaaaagg cgctactttt aatcgagaaa caccaggagt tcccattgct 1080
tatacaacaa acttcctaaa agacaatgaa ttagctgtta ttaaaaacaa ctcagaatat 1140
attgaaacaa cttcaaaagc ttatacagat ggaaaaatta acatcgatca ctctggagga 1200
tacgttgctc aattcaacat ttcttgggat gaagtaaatt atgat                 1245

<210> 24
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> fragment

<400> 24
Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu
 1               5                  10                  15      
Pro Ile Ala Gln Gln Thr Glu Ala Lys Asp Ala Ser Ala Phe Asn Lys
            20                  25                  30          
Glu Glu Ile Asp Lys Tyr Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn
        35                  40                  45              
Val Leu Val Tyr His Gly Asp Ala Val Thr Asn Val Pro Pro Arg Lys
    50                  55                  60                  
Gly Tyr Lys Asp Gly Asn Glu Tyr Ile Val Val Glu Lys Lys Lys Lys
65                  70                  75                  80  
Ser Ile Asn Gln Asn Asn Ala Asp Ile Gln Val Val Asn Ala Ile Ser
                85                  90                  95      
Ser Leu Thr Tyr Pro Gly Ala Leu Val Lys Ala Asn Ser Glu Leu Val
            100                 105                 110         
Glu Asn Gln Pro Asp Val Leu Pro Val Lys Arg Asp Ser Leu Thr Leu
        115                 120                 125             
Ser Ile Asp Leu Pro Gly Met Thr Asn Gln Asp Asn Lys Ile Val Val
    130                 135                 140                 
Lys Asn Ala Thr Lys Ser Asn Val Asn Asn Ala Val Asn Thr Leu Val
145                 150                 155                 160 
Glu Arg Trp Asn Glu Lys Tyr Ala Gln Ala Tyr Pro Asn Val Ser Ala
                165                 170                 175     
Lys Ile Asp Tyr Asp Asp Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile
            180                 185                 190         
Ala Lys Phe Gly Thr Ala Phe Lys Ala Val Asn Asn Ser Leu Asn Val
        195                 200                 205             
Asn Phe Gly Ala Ile Ser Glu Gly Lys Met Gln Glu Glu Val Ile Ser
    210                 215                 220                 
Phe Lys Gln Ile Tyr Tyr Asn Val Asn Val Asn Glu Pro Thr Arg Pro
225                 230                 235                 240 
Ser Arg Phe Phe Gly Lys Ala Val Thr Lys Glu Gln Leu Gln Ala Leu
                245                 250                 255     
Gly Val Asn Ala Glu Asn Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr
            260                 265                 270         
Gly Arg Gln Val Tyr Leu Lys Leu Ser Thr Asn Ser His Ser Thr Lys
        275                 280                 285             
Val Lys Ala Ala Phe Asp Ala Ala Val Ser Gly Lys Ser Val Ser Gly
    290                 295                 300                 
Asp Val Glu Leu Thr Asn Ile Ile Lys Asn Ser Ser Phe Lys Ala Val
305                 310                 315                 320 
Ile Tyr Gly Gly Ser Ala Lys Asp Glu Val Gln Ile Ile Asp Gly Asn
                325                 330                 335     
Leu Gly Asp Leu Arg Asp Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg
            340                 345                 350         
Glu Thr Pro Gly Val Pro Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp
        355                 360                 365             
Asn Glu Leu Ala Val Ile Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr
    370                 375                 380                 
Ser Lys Ala Tyr Thr Asp Gly Lys Ile Asn Ile Asp His Ser Gly Gly
385                 390                 395                 400 
Tyr Val Ala Gln Phe Asn Ile Ser Trp Asp Glu Val Asn Tyr Asp
                405                 410                 415 


<210> 25
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> fragment

<400> 25
Pro Ala Ser Arg Leu Glu Glu Lys Lys Gly Asn Tyr Val Val Thr Asp
 1               5                  10                  15      
His Gly Ser Cys
            20  


<210> 26
<211> 34
<212> PRT
<213> Artificial Sequence

<220> 
<223> fragment

<400> 26
Ala Ser Lys Val Leu Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Gly
 1               5                  10                  15      
Asn Tyr Val Val Thr Asp His Gly Ser Cys Ala Asp Gly Ser Val Lys
            20                  25                  30          
Thr Ser
        


<210> 27
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> fragment

<400> 27
Ala Ser Lys Val Ala Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Gly
 1               5                  10                  15      
Asn Tyr Val Val Thr Asp His Gly Ser Cys Gly Asp Gly Ser Ile Lys
            20                  25                  30          


<210> 28
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> fragment

<400> 28
Leu Ser Lys Val Leu Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Gly
 1               5                  10                  15      
Asn Tyr Val Val Thr Asp His Gly Ser Cys Ala Asp Gly Ser Val Lys
            20                  25                  30          


<210> 29
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> fragment

<400> 29
Ala Ser Lys Val Ala Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Gly
 1               5                  10                  15      
Asn Tyr Val Val Thr Asp His Gly Ser Cys Gly Asp Gly Ser Ile Lys
            20                  25                  30          


<210> 30
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> fragment

<400> 30
Leu Ser Lys Val Leu Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Gly
 1               5                  10                  15      
Asn Tyr Val Val Thr Asp His Gly Ser Cys Ala Asp Gly Ser Val Lys
            20                  25                  30          


<210> 31
<211> 300
<212> DNA
<213> Artificial Sequence

<220> 
<223> ActAN100

<400> 31
gtgggattaa atagatttat gcgtgcgatg atggtagttt tcattactgc caactgcatt 60
acgattaacc ccgacataat atttgcagcg acagatagcg aagattccag tctaaacaca 120
gatgaatggg aagaagaaaa aacagaagag cagccaagcg aggtaaatac gggaccaaga 180
tacgaaactg cacgtgaagt aagttcacgt gatattgagg aactagaaaa atcgaataaa 240
gtgaaaaata cgaacaaagc agacctaata gcaatgttga aagcaaaagc agagaaaggt 300


<210> 32
<211> 100
<212> PRT
<213> Artificial Sequence

<220> 
<223> ActAN100

<400> 32
Met Gly Leu Asn Arg Phe Met Arg Ala Met Met Val Val Phe Ile Thr
 1               5                  10                  15      
Ala Asn Cys Ile Thr Ile Asn Pro Asp Ile Ile Phe Ala Ala Thr Asp
            20                  25                  30          
Ser Glu Asp Ser Ser Leu Asn Thr Asp Glu Trp Glu Glu Glu Lys Thr
        35                  40                  45              
Glu Glu Gln Pro Ser Glu Val Asn Thr Gly Pro Arg Tyr Glu Thr Ala
    50                  55                  60                  
Arg Glu Val Ser Ser Arg Asp Ile Glu Glu Leu Glu Lys Ser Asn Lys
65                  70                  75                  80  
Val Lys Asn Thr Asn Lys Ala Asp Leu Ile Ala Met Leu Lys Ala Lys
                85                  90                  95      
Ala Glu Lys Gly
            100 

