                               SEQUENCE LISTING

<110> PRESIDENT AND FELLOWS OF HARVARD COLLEGE
 
<120> TARGETED CYTOSOLIC DELIVERY OF ANTIGENIC COMPOUNDS

<130> 002806-081971-PCT

<140> PCT/US2016/026902
<141> 2016-04-11

<150> 62/146,652
<151> 2015-04-13

<160> 19    

<170> PatentIn version 3.5

<210> 1
<211> 809
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide 

<400> 1
Met Asn Ile Lys Lys Glu Phe Ile Lys Val Ile Ser Met Ser Cys Leu 
1               5                   10                  15      


Val Thr Ala Ile Thr Leu Ser Gly Pro Val Phe Ile Pro Leu Val Gln 
            20                  25                  30          


Gly Ala Gly Gly His Gly Asp Val Gly Met His Val Lys Glu Lys Glu 
        35                  40                  45              


Lys Asn Lys Asp Glu Asn Lys Arg Lys Asp Glu Glu Arg Asn Lys Thr 
    50                  55                  60                  


Gln Glu Glu His Leu Lys Glu Ile Met Lys His Ile Val Lys Ile Glu 
65                  70                  75                  80  


Val Lys Gly Glu Glu Ala Val Lys Lys Glu Ala Ala Glu Lys Leu Leu 
                85                  90                  95      


Glu Lys Val Pro Ser Asp Val Leu Glu Met Tyr Lys Ala Ile Gly Gly 
            100                 105                 110         


Lys Ile Tyr Ile Val Asp Gly Asp Ile Thr Lys His Ile Ser Leu Glu 
        115                 120                 125             


Ala Leu Ser Glu Asp Lys Lys Lys Ile Lys Asp Ile Tyr Gly Lys Asp 
    130                 135                 140                 


Ala Leu Leu His Glu His Tyr Val Tyr Ala Lys Glu Gly Tyr Glu Pro 
145                 150                 155                 160 


Val Leu Val Ile Gln Ser Ser Glu Asp Tyr Val Glu Asn Thr Glu Lys 
                165                 170                 175     


Ala Leu Asn Val Tyr Tyr Glu Ile Gly Lys Ile Leu Ser Arg Asp Ile 
            180                 185                 190         


Leu Ser Lys Ile Asn Gln Pro Tyr Gln Lys Phe Leu Asp Val Leu Asn 
        195                 200                 205             


Thr Ile Lys Asn Ala Ser Asp Ser Asp Gly Gln Asp Leu Leu Phe Thr 
    210                 215                 220                 


Asn Gln Leu Lys Glu His Pro Thr Asp Phe Ser Val Glu Phe Leu Glu 
225                 230                 235                 240 


Gln Asn Ser Asn Glu Val Gln Glu Val Phe Ala Lys Ala Phe Ala Tyr 
                245                 250                 255     


Tyr Ile Glu Pro Gln His Arg Asp Val Leu Gln Leu Tyr Ala Pro Glu 
            260                 265                 270         


Ala Phe Asn Tyr Met Asp Lys Phe Asn Glu Gln Glu Ile Asn Leu Ser 
        275                 280                 285             


Leu Glu Glu Leu Lys Asp Gln Arg Met Leu Ala Arg Tyr Glu Lys Trp 
    290                 295                 300                 


Glu Lys Ile Lys Gln His Tyr Gln His Trp Ser Asp Ser Leu Ser Glu 
305                 310                 315                 320 


Glu Gly Arg Gly Leu Leu Lys Lys Leu Gln Ile Pro Ile Glu Pro Lys 
                325                 330                 335     


Lys Asp Asp Ile Ile His Ser Leu Ser Gln Glu Glu Lys Glu Leu Leu 
            340                 345                 350         


Lys Arg Ile Gln Ile Asp Ser Ser Asp Phe Leu Ser Thr Glu Glu Lys 
        355                 360                 365             


Glu Phe Leu Lys Lys Leu Gln Ile Asp Ile Arg Asp Ser Leu Ser Glu 
    370                 375                 380                 


Glu Glu Lys Glu Leu Leu Asn Arg Ile Gln Val Asp Ser Ser Asn Pro 
385                 390                 395                 400 


Leu Ser Glu Lys Glu Lys Glu Phe Leu Lys Lys Leu Lys Leu Asp Ile 
                405                 410                 415     


Gln Pro Tyr Asp Ile Asn Gln Arg Leu Gln Asp Thr Gly Gly Leu Ile 
            420                 425                 430         


Asp Ser Pro Ser Ile Asn Leu Asp Val Arg Lys Gln Tyr Lys Arg Asp 
        435                 440                 445             


Ile Gln Asn Ile Asp Ala Leu Leu His Gln Ser Ile Gly Ser Thr Leu 
    450                 455                 460                 


Tyr Asn Lys Ile Tyr Leu Tyr Glu Asn Met Asn Ile Asn Asn Leu Thr 
465                 470                 475                 480 


Ala Thr Leu Gly Ala Asp Leu Val Asp Ser Thr Asp Asn Thr Lys Ile 
                485                 490                 495     


Asn Arg Gly Ile Phe Asn Glu Phe Lys Lys Asn Phe Lys Tyr Ser Ile 
            500                 505                 510         


Ser Ser Asn Tyr Met Ile Val Asp Ile Asn Glu Arg Pro Ala Leu Asp 
        515                 520                 525             


Asn Glu Arg Leu Lys Trp Arg Ile Gln Leu Ser Pro Asp Thr Arg Ala 
    530                 535                 540                 


Gly Tyr Leu Glu Asn Gly Lys Leu Ile Leu Gln Arg Asn Ile Gly Leu 
545                 550                 555                 560 


Glu Ile Lys Asp Val Gln Ile Ile Lys Gln Ser Glu Lys Glu Tyr Ile 
                565                 570                 575     


Arg Ile Asp Ala Lys Val Val Pro Lys Ser Lys Ile Asp Thr Lys Ile 
            580                 585                 590         


Gln Glu Ala Gln Leu Asn Ile Asn Gln Glu Trp Asn Lys Ala Leu Gly 
        595                 600                 605             


Leu Pro Lys Tyr Thr Lys Leu Ile Thr Phe Asn Val His Asn Arg Tyr 
    610                 615                 620                 


Ala Ser Asn Ile Val Glu Ser Ala Tyr Leu Ile Leu Asn Glu Trp Lys 
625                 630                 635                 640 


Asn Asn Ile Gln Ser Asp Leu Ile Lys Lys Val Thr Asn Tyr Leu Val 
                645                 650                 655     


Asp Gly Asn Gly Arg Phe Val Phe Thr Asp Ile Thr Leu Pro Asn Ile 
            660                 665                 670         


Ala Glu Gln Tyr Thr His Gln Asp Glu Ile Tyr Glu Gln Val His Ser 
        675                 680                 685             


Lys Gly Leu Tyr Val Pro Glu Ser Arg Ser Ile Leu Leu His Gly Pro 
    690                 695                 700                 


Ser Lys Gly Val Glu Leu Arg Asn Asp Ser Glu Gly Phe Ile His Glu 
705                 710                 715                 720 


Phe Gly His Ala Val Asp Asp Tyr Ala Gly Tyr Leu Leu Asp Lys Asn 
                725                 730                 735     


Gln Ser Asp Leu Val Thr Asn Ser Lys Lys Phe Ile Asp Ile Phe Lys 
            740                 745                 750         


Glu Glu Gly Ser Asn Leu Thr Ser Tyr Gly Arg Thr Asn Glu Ala Glu 
        755                 760                 765             


Phe Phe Ala Glu Ala Phe Arg Leu Met His Ser Thr Asp His Ala Glu 
    770                 775                 780                 


Arg Leu Lys Val Gln Lys Asn Ala Pro Lys Thr Phe Gln Phe Ile Asn 
785                 790                 795                 800 


Asp Gln Ile Lys Phe Ile Ile Asn Ser 
                805                 


<210> 2
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide 

<400> 2
Met Asn Ile Lys Lys Glu Phe Ile Lys Val Ile Ser Met Ser Cys Leu 
1               5                   10                  15      


Val Thr Ala Ile Thr Leu Ser Gly Pro Val Phe Ile Pro Leu Val Gln 
            20                  25                  30          


Gly 
    


<210> 3
<211> 776
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide 

<400> 3
Ala Gly Gly His Gly Asp Val Gly Met His Val Lys Glu Lys Glu Lys 
1               5                   10                  15      


Asn Lys Asp Glu Asn Lys Arg Lys Asp Glu Glu Arg Asn Lys Thr Gln 
            20                  25                  30          


Glu Glu His Leu Lys Glu Ile Met Lys His Ile Val Lys Ile Glu Val 
        35                  40                  45              


Lys Gly Glu Glu Ala Val Lys Lys Glu Ala Ala Glu Lys Leu Leu Glu 
    50                  55                  60                  


Lys Val Pro Ser Asp Val Leu Glu Met Tyr Lys Ala Ile Gly Gly Lys 
65                  70                  75                  80  


Ile Tyr Ile Val Asp Gly Asp Ile Thr Lys His Ile Ser Leu Glu Ala 
                85                  90                  95      


Leu Ser Glu Asp Lys Lys Lys Ile Lys Asp Ile Tyr Gly Lys Asp Ala 
            100                 105                 110         


Leu Leu His Glu His Tyr Val Tyr Ala Lys Glu Gly Tyr Glu Pro Val 
        115                 120                 125             


Leu Val Ile Gln Ser Ser Glu Asp Tyr Val Glu Asn Thr Glu Lys Ala 
    130                 135                 140                 


Leu Asn Val Tyr Tyr Glu Ile Gly Lys Ile Leu Ser Arg Asp Ile Leu 
145                 150                 155                 160 


Ser Lys Ile Asn Gln Pro Tyr Gln Lys Phe Leu Asp Val Leu Asn Thr 
                165                 170                 175     


Ile Lys Asn Ala Ser Asp Ser Asp Gly Gln Asp Leu Leu Phe Thr Asn 
            180                 185                 190         


Gln Leu Lys Glu His Pro Thr Asp Phe Ser Val Glu Phe Leu Glu Gln 
        195                 200                 205             


Asn Ser Asn Glu Val Gln Glu Val Phe Ala Lys Ala Phe Ala Tyr Tyr 
    210                 215                 220                 


Ile Glu Pro Gln His Arg Asp Val Leu Gln Leu Tyr Ala Pro Glu Ala 
225                 230                 235                 240 


Phe Asn Tyr Met Asp Lys Phe Asn Glu Gln Glu Ile Asn Leu Ser Leu 
                245                 250                 255     


Glu Glu Leu Lys Asp Gln Arg Met Leu Ala Arg Tyr Glu Lys Trp Glu 
            260                 265                 270         


Lys Ile Lys Gln His Tyr Gln His Trp Ser Asp Ser Leu Ser Glu Glu 
        275                 280                 285             


Gly Arg Gly Leu Leu Lys Lys Leu Gln Ile Pro Ile Glu Pro Lys Lys 
    290                 295                 300                 


Asp Asp Ile Ile His Ser Leu Ser Gln Glu Glu Lys Glu Leu Leu Lys 
305                 310                 315                 320 


Arg Ile Gln Ile Asp Ser Ser Asp Phe Leu Ser Thr Glu Glu Lys Glu 
                325                 330                 335     


Phe Leu Lys Lys Leu Gln Ile Asp Ile Arg Asp Ser Leu Ser Glu Glu 
            340                 345                 350         


Glu Lys Glu Leu Leu Asn Arg Ile Gln Val Asp Ser Ser Asn Pro Leu 
        355                 360                 365             


Ser Glu Lys Glu Lys Glu Phe Leu Lys Lys Leu Lys Leu Asp Ile Gln 
    370                 375                 380                 


Pro Tyr Asp Ile Asn Gln Arg Leu Gln Asp Thr Gly Gly Leu Ile Asp 
385                 390                 395                 400 


Ser Pro Ser Ile Asn Leu Asp Val Arg Lys Gln Tyr Lys Arg Asp Ile 
                405                 410                 415     


Gln Asn Ile Asp Ala Leu Leu His Gln Ser Ile Gly Ser Thr Leu Tyr 
            420                 425                 430         


Asn Lys Ile Tyr Leu Tyr Glu Asn Met Asn Ile Asn Asn Leu Thr Ala 
        435                 440                 445             


Thr Leu Gly Ala Asp Leu Val Asp Ser Thr Asp Asn Thr Lys Ile Asn 
    450                 455                 460                 


Arg Gly Ile Phe Asn Glu Phe Lys Lys Asn Phe Lys Tyr Ser Ile Ser 
465                 470                 475                 480 


Ser Asn Tyr Met Ile Val Asp Ile Asn Glu Arg Pro Ala Leu Asp Asn 
                485                 490                 495     


Glu Arg Leu Lys Trp Arg Ile Gln Leu Ser Pro Asp Thr Arg Ala Gly 
            500                 505                 510         


Tyr Leu Glu Asn Gly Lys Leu Ile Leu Gln Arg Asn Ile Gly Leu Glu 
        515                 520                 525             


Ile Lys Asp Val Gln Ile Ile Lys Gln Ser Glu Lys Glu Tyr Ile Arg 
    530                 535                 540                 


Ile Asp Ala Lys Val Val Pro Lys Ser Lys Ile Asp Thr Lys Ile Gln 
545                 550                 555                 560 


Glu Ala Gln Leu Asn Ile Asn Gln Glu Trp Asn Lys Ala Leu Gly Leu 
                565                 570                 575     


Pro Lys Tyr Thr Lys Leu Ile Thr Phe Asn Val His Asn Arg Tyr Ala 
            580                 585                 590         


Ser Asn Ile Val Glu Ser Ala Tyr Leu Ile Leu Asn Glu Trp Lys Asn 
        595                 600                 605             


Asn Ile Gln Ser Asp Leu Ile Lys Lys Val Thr Asn Tyr Leu Val Asp 
    610                 615                 620                 


Gly Asn Gly Arg Phe Val Phe Thr Asp Ile Thr Leu Pro Asn Ile Ala 
625                 630                 635                 640 


Glu Gln Tyr Thr His Gln Asp Glu Ile Tyr Glu Gln Val His Ser Lys 
                645                 650                 655     


Gly Leu Tyr Val Pro Glu Ser Arg Ser Ile Leu Leu His Gly Pro Ser 
            660                 665                 670         


Lys Gly Val Glu Leu Arg Asn Asp Ser Glu Gly Phe Ile His Glu Phe 
        675                 680                 685             


Gly His Ala Val Asp Asp Tyr Ala Gly Tyr Leu Leu Asp Lys Asn Gln 
    690                 695                 700                 


Ser Asp Leu Val Thr Asn Ser Lys Lys Phe Ile Asp Ile Phe Lys Glu 
705                 710                 715                 720 


Glu Gly Ser Asn Leu Thr Ser Tyr Gly Arg Thr Asn Glu Ala Glu Phe 
                725                 730                 735     


Phe Ala Glu Ala Phe Arg Leu Met His Ser Thr Asp His Ala Glu Arg 
            740                 745                 750         


Leu Lys Val Gln Lys Asn Ala Pro Lys Thr Phe Gln Phe Ile Asn Asp 
        755                 760                 765             


Gln Ile Lys Phe Ile Ile Asn Ser 
    770                 775     


<210> 4
<211> 9
<212> PRT
<213> Human papillomavirus

<400> 4
Arg Ala His Tyr Asn Ile Val Thr Phe 
1               5                   


<210> 5
<211> 10
<212> PRT
<213> Homo sapiens

<400> 5
Phe Tyr Gln Leu Ala Lys Thr Cys Pro Val 
1               5                   10  


<210> 6
<211> 15
<212> PRT
<213> Human immunodeficiency virus

<400> 6
Arg Ile Gln Arg Gly Pro Gly Arg Ala Phe Val Thr Ile Gly Lys 
1               5                   10                  15  


<210> 7
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MAGE-1 peptide 

<400> 7
Ser Ala Tyr Gly Glu Pro Arg Lys Leu 
1               5                   


<210> 8
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MAGE-3 peptide 

<400> 8
Phe Leu Trp Gly Pro Arg Ala Leu Val 
1               5                   


<210> 9
<211> 9
<212> PRT
<213> Homo sapiens

<400> 9
Met Leu Leu Ala Val Leu Tyr Cys Leu 
1               5                   


<210> 10
<211> 9
<212> PRT
<213> Homo sapiens

<400> 10
Tyr Met Asn Gly Thr Met Ser Gln Val 
1               5                   


<210> 11
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Listeriolysin-O peptide 

<400> 11
Gly Tyr Lys Asp Gly Asn Glu Tyr Ile 
1               5                   


<210> 12
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      P60 peptide

<400> 12
Lys Tyr Gly Val Ser Val Gln Asp Ile 
1               5                   


<210> 13
<211> 12
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MART-1 M-9 peptide

<400> 13
Ala Ala Ala Ala Ala Gly Ile Gly Ile Leu Thr Val 
1               5                   10          


<210> 14
<211> 10
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MART-1 M10-3 peptide

<400> 14
Glu Ala Ala Gly Ile Gly Ile Leu Thr Val 
1               5                   10  


<210> 15
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      BAGE-1 peptide

<400> 15
Ala Ala Arg Ala Val Phe Leu Ala Leu 
1               5                   


<210> 16
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      P1A peptide

<400> 16
Leu Pro Tyr Leu Gly Trp Leu Val Phe 
1               5                   


<210> 17
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Connexin gap junction derived Mut 1 peptide

<400> 17
Phe Glu Gln Asn Thr Ala Gln Pro 
1               5               


<210> 18
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Connexin gap junction derived Mut 2 peptide 

<400> 18
Phe Glu Gln Asn Thr Ala Gln Ala 
1               5               


<210> 19
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Ser Ile Ile Asn Phe Glu Lys Leu 
1               5               


