                         SEQUENCE LISTING

<110>  ELSALYS
       CNRS
       INSTITUT CURIE
 
<120>  Anti-Tyro3 antibodies and uses thereof

<130>  B2010PC

<160>  194   

<170>  PatentIn version 3.5

<210>  1
<211>  890
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(40)

<220>
<221>  MISC_FEATURE
<222>  (41)..(128)
<223>  immunoglobulin-like domain Ig-1

<220>
<221>  MISC_FEATURE
<222>  (139)..(220)
<223>  immunoglobulin-like domain Ig-2

<220>
<221>  MISC_FEATURE
<222>  (227)..(320)
<223>  Fibronectin type III-like domain FNIII-1

<220>
<221>  MISC_FEATURE
<222>  (325)..(416)
<223>  Fibronectin type III-like domain FNIII-2

<220>
<221>  MISC_FEATURE
<222>  (518)..(790)
<223>  Tyrosine kinase domain

<400>  1

Met Ala Leu Arg Arg Ser Met Gly Arg Pro Gly Leu Pro Pro Leu Pro 
1               5                   10                  15      


Leu Pro Pro Pro Pro Arg Leu Gly Leu Leu Leu Ala Ala Leu Ala Ser 
            20                  25                  30          


Leu Leu Leu Pro Glu Ser Ala Ala Ala Gly Leu Lys Leu Met Gly Ala 
        35                  40                  45              


Pro Val Lys Leu Thr Val Ser Gln Gly Gln Pro Val Lys Leu Asn Cys 
    50                  55                  60                  


Ser Val Glu Gly Met Glu Glu Pro Asp Ile Gln Trp Val Lys Asp Gly 
65                  70                  75                  80  


Ala Val Val Gln Asn Leu Asp Gln Leu Tyr Ile Pro Val Ser Glu Gln 
                85                  90                  95      


His Trp Ile Gly Phe Leu Ser Leu Lys Ser Val Glu Arg Ser Asp Ala 
            100                 105                 110         


Gly Arg Tyr Trp Cys Gln Val Glu Asp Gly Gly Glu Thr Glu Ile Ser 
        115                 120                 125             


Gln Pro Val Trp Leu Thr Val Glu Gly Val Pro Phe Phe Thr Val Glu 
    130                 135                 140                 


Pro Lys Asp Leu Ala Val Pro Pro Asn Ala Pro Phe Gln Leu Ser Cys 
145                 150                 155                 160 


Glu Ala Val Gly Pro Pro Glu Pro Val Thr Ile Val Trp Trp Arg Gly 
                165                 170                 175     


Thr Thr Lys Ile Gly Gly Pro Ala Pro Ser Pro Ser Val Leu Asn Val 
            180                 185                 190         


Thr Gly Val Thr Gln Ser Thr Met Phe Ser Cys Glu Ala His Asn Leu 
        195                 200                 205             


Lys Gly Leu Ala Ser Ser Arg Thr Ala Thr Val His Leu Gln Ala Leu 
    210                 215                 220                 


Pro Ala Ala Pro Phe Asn Ile Thr Val Thr Lys Leu Ser Ser Ser Asn 
225                 230                 235                 240 


Ala Ser Val Ala Trp Met Pro Gly Ala Asp Gly Arg Ala Leu Leu Gln 
                245                 250                 255     


Ser Cys Thr Val Gln Val Thr Gln Ala Pro Gly Gly Trp Glu Val Leu 
            260                 265                 270         


Ala Val Val Val Pro Val Pro Pro Phe Thr Cys Leu Leu Arg Asp Leu 
        275                 280                 285             


Val Pro Ala Thr Asn Tyr Ser Leu Arg Val Arg Cys Ala Asn Ala Leu 
    290                 295                 300                 


Gly Pro Ser Pro Tyr Ala Asp Trp Val Pro Phe Gln Thr Lys Gly Leu 
305                 310                 315                 320 


Ala Pro Ala Ser Ala Pro Gln Asn Leu His Ala Ile Arg Thr Asp Ser 
                325                 330                 335     


Gly Leu Ile Leu Glu Trp Glu Glu Val Ile Pro Glu Ala Pro Leu Glu 
            340                 345                 350         


Gly Pro Leu Gly Pro Tyr Lys Leu Ser Trp Val Gln Asp Asn Gly Thr 
        355                 360                 365             


Gln Asp Glu Leu Thr Val Glu Gly Thr Arg Ala Asn Leu Thr Gly Trp 
    370                 375                 380                 


Asp Pro Gln Lys Asp Leu Ile Val Arg Val Cys Val Ser Asn Ala Val 
385                 390                 395                 400 


Gly Cys Gly Pro Trp Ser Gln Pro Leu Val Val Ser Ser His Asp Arg 
                405                 410                 415     


Ala Gly Gln Gln Gly Pro Pro His Ser Arg Thr Ser Trp Val Pro Val 
            420                 425                 430         


Val Leu Gly Val Leu Thr Ala Leu Val Thr Ala Ala Ala Leu Ala Leu 
        435                 440                 445             


Ile Leu Leu Arg Lys Arg Arg Lys Glu Thr Arg Phe Gly Gln Ala Phe 
    450                 455                 460                 


Asp Ser Val Met Ala Arg Gly Glu Pro Ala Val His Phe Arg Ala Ala 
465                 470                 475                 480 


Arg Ser Phe Asn Arg Glu Arg Pro Glu Arg Ile Glu Ala Thr Leu Asp 
                485                 490                 495     


Ser Leu Gly Ile Ser Asp Glu Leu Lys Glu Lys Leu Glu Asp Val Leu 
            500                 505                 510         


Ile Pro Glu Gln Gln Phe Thr Leu Gly Arg Met Leu Gly Lys Gly Glu 
        515                 520                 525             


Phe Gly Ser Val Arg Glu Ala Gln Leu Lys Gln Glu Asp Gly Ser Phe 
    530                 535                 540                 


Val Lys Val Ala Val Lys Met Leu Lys Ala Asp Ile Ile Ala Ser Ser 
545                 550                 555                 560 


Asp Ile Glu Glu Phe Leu Arg Glu Ala Ala Cys Met Lys Glu Phe Asp 
                565                 570                 575     


His Pro His Val Ala Lys Leu Val Gly Val Ser Leu Arg Ser Arg Ala 
            580                 585                 590         


Lys Gly Arg Leu Pro Ile Pro Met Val Ile Leu Pro Phe Met Lys His 
        595                 600                 605             


Gly Asp Leu His Ala Phe Leu Leu Ala Ser Arg Ile Gly Glu Asn Pro 
    610                 615                 620                 


Phe Asn Leu Pro Leu Gln Thr Leu Ile Arg Phe Met Val Asp Ile Ala 
625                 630                 635                 640 


Cys Gly Met Glu Tyr Leu Ser Ser Arg Asn Phe Ile His Arg Asp Leu 
                645                 650                 655     


Ala Ala Arg Asn Cys Met Leu Ala Glu Asp Met Thr Val Cys Val Ala 
            660                 665                 670         


Asp Phe Gly Leu Ser Arg Lys Ile Tyr Ser Gly Asp Tyr Tyr Arg Gln 
        675                 680                 685             


Gly Cys Ala Ser Lys Leu Pro Val Lys Trp Leu Ala Leu Glu Ser Leu 
    690                 695                 700                 


Ala Asp Asn Leu Tyr Thr Val Gln Ser Asp Val Trp Ala Phe Gly Val 
705                 710                 715                 720 


Thr Met Trp Glu Ile Met Thr Arg Gly Gln Thr Pro Tyr Ala Gly Ile 
                725                 730                 735     


Glu Asn Ala Glu Ile Tyr Asn Tyr Leu Ile Gly Gly Asn Arg Leu Lys 
            740                 745                 750         


Gln Pro Pro Glu Cys Met Glu Asp Val Tyr Asp Leu Met Tyr Gln Cys 
        755                 760                 765             


Trp Ser Ala Asp Pro Lys Gln Arg Pro Ser Phe Thr Cys Leu Arg Met 
    770                 775                 780                 


Glu Leu Glu Asn Ile Leu Gly Gln Leu Ser Val Leu Ser Ala Ser Gln 
785                 790                 795                 800 


Asp Pro Leu Tyr Ile Asn Ile Glu Arg Ala Glu Glu Pro Thr Ala Gly 
                805                 810                 815     


Gly Ser Leu Glu Leu Pro Gly Arg Asp Gln Pro Tyr Ser Gly Ala Gly 
            820                 825                 830         


Asp Gly Ser Gly Met Gly Ala Val Gly Gly Thr Pro Ser Asp Cys Arg 
        835                 840                 845             


Tyr Ile Leu Thr Pro Gly Gly Leu Ala Glu Gln Pro Gly Gln Ala Glu 
    850                 855                 860                 


His Gln Pro Glu Ser Pro Leu Asn Glu Thr Gln Arg Leu Leu Leu Leu 
865                 870                 875                 880 


Gln Gln Gly Leu Leu Pro His Ser Ser Cys 
                885                 890 


<210>  2
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Gly Leu Lys Leu Met Gly Ala Pro Val Lys Leu Thr Val Ser Gln 
1               5                   10                  15      


Gly Gln Pro Val Lys Leu Asn Cys Ser Val Glu Gly Met Glu Glu Pro 
            20                  25                  30          


Asp Ile Gln Trp Val Lys Asp Gly Ala Val Val Gln Asn Leu Asp Gln 
        35                  40                  45              


Leu Tyr Ile Pro Val Ser Glu Gln His Trp Ile Gly Phe Leu Ser Leu 
    50                  55                  60                  


Lys Ser Val Glu Arg Ser Asp Ala Gly Arg Tyr Trp Cys Gln Val Glu 
65                  70                  75                  80  


Asp Gly Gly Glu Thr Glu Ile Ser Gln Pro Val Trp Leu Thr 
                85                  90                  


<210>  3
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Gly Leu Lys Leu Met Gly Ala Pro Val Lys Leu Thr Val Ser Gln 
1               5                   10                  15      


Gly Gln Pro Val Lys Leu Asn Cys Ser Val Glu Gly Met Glu Glu Pro 
            20                  25                  30          


Asp Ile Gln Trp Val Lys Asp Gly Ala Val Val Gln Asn Leu Asp Gln 
        35                  40                  45              


Leu Tyr Ile Pro Val Ser Glu Gln His Trp Ile Gly Phe Leu Ser Leu 
    50                  55                  60                  


Lys Ser Val Glu Arg Ser Asp Ala Gly Arg Tyr Trp Cys Gln Val Glu 
65                  70                  75                  80  


Asp Gly Gly Glu Thr Glu Ile Ser Gln Pro Val Trp Leu Thr Val Glu 
                85                  90                  95      


Gly Val Pro Phe Phe Thr Val Glu Pro Lys Asp Leu Ala Val Pro Pro 
            100                 105                 110         


Asn Ala Pro Phe Gln Leu Ser Cys Glu Ala Val Gly Pro Pro Glu Pro 
        115                 120                 125             


Val Thr Ile Val Trp Trp Arg Gly Thr Thr Lys Ile Gly Gly Pro Ala 
    130                 135                 140                 


Pro Ser Pro Ser Val Leu Asn Val Thr Gly Val Thr Gln Ser Thr Met 
145                 150                 155                 160 


Phe Ser Cys Glu Ala His Asn Leu Lys Gly Leu Ala Ser Ser Arg Thr 
                165                 170                 175     


Ala Thr Val His Leu Gln 
            180         


<210>  4
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  4

Val Pro Phe Phe Thr Val Glu Pro Lys Asp Leu Ala Val Pro Pro Asn 
1               5                   10                  15      


Ala Pro Phe Gln Leu Ser Cys Glu Ala Val Gly Pro Pro Glu Pro Val 
            20                  25                  30          


Thr Ile Val Trp Trp Arg Gly Thr Thr Lys Ile Gly Gly Pro Ala Pro 
        35                  40                  45              


Ser Pro Ser Val Leu Asn Val Thr Gly Val Thr Gln Ser Thr Met Phe 
    50                  55                  60                  


Ser Cys Glu Ala His Asn Leu Lys Gly Leu Ala Ser Ser Arg Thr Ala 
65                  70                  75                  80  


Thr Val His Leu Gln Ala Leu Pro Ala Ala Pro Phe Asn Ile Thr Val 
                85                  90                  95      


Thr Lys Leu Ser Ser Ser Asn Ala Ser Val Ala Trp Met Pro Gly Ala 
            100                 105                 110         


Asp Gly Arg Ala Leu Leu Gln Ser Cys Thr Val Gln Val Thr Gln Ala 
        115                 120                 125             


Pro Gly Gly Trp Glu Val Leu Ala Val Val Val Pro Val Pro Pro Phe 
    130                 135                 140                 


Thr Cys Leu Leu Arg Asp Leu Val Pro Ala Thr Asn Tyr Ser Leu Arg 
145                 150                 155                 160 


Val Arg Cys Ala Asn Ala Leu Gly Pro Ser Pro Tyr Ala Asp Trp Val 
                165                 170                 175     


Pro Phe Gln Thr Lys Gly Leu Ala 
            180                 


<210>  5
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  5

Ala Ala Pro Phe Asn Ile Thr Val Thr Lys Leu Ser Ser Ser Asn Ala 
1               5                   10                  15      


Ser Val Ala Trp Met Pro Gly Ala Asp Gly Arg Ala Leu Leu Gln Ser 
            20                  25                  30          


Cys Thr Val Gln Val Thr Gln Ala Pro Gly Gly Trp Glu Val Leu Ala 
        35                  40                  45              


Val Val Val Pro Val Pro Pro Phe Thr Cys Leu Leu Arg Asp Leu Val 
    50                  55                  60                  


Pro Ala Thr Asn Tyr Ser Leu Arg Val Arg Cys Ala Asn Ala Leu Gly 
65                  70                  75                  80  


Pro Ser Pro Tyr Ala Asp Trp Val Pro Phe Gln Thr Lys Gly Leu Ala 
                85                  90                  95      


Pro Ala Ser Ala Pro Gln Asn Leu His Ala Ile Arg Thr Asp Ser Gly 
            100                 105                 110         


Leu Ile Leu Glu Trp Glu Glu Val Ile Pro Glu Ala Pro Leu Glu Gly 
        115                 120                 125             


Pro Leu Gly Pro Tyr Lys Leu Ser Trp Val Gln Asp Asn Gly Thr Gln 
    130                 135                 140                 


Asp Glu Leu Thr Val Glu Gly Thr Arg Ala Asn Leu Thr Gly Trp Asp 
145                 150                 155                 160 


Pro Gln Lys Asp Leu Ile Val Arg Val Cys Val Ser Asn Ala Val Gly 
                165                 170                 175     


Cys Gly Pro Trp Ser Gln Pro Leu Val Val Ser Ser His Asp Arg 
            180                 185                 190     


<210>  6
<211>  894
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(25)

<220>
<221>  DOMAIN
<222>  (26)..(451)
<223>  Extracellular domain

<400>  6

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln 
            420                 425                 430         


Pro Val His Gln Leu Val Lys Glu Pro Ser Thr Pro Ala Phe Ser Trp 
        435                 440                 445             


Pro Trp Trp Tyr Val Leu Leu Gly Ala Val Val Ala Ala Ala Cys Val 
    450                 455                 460                 


Leu Ile Leu Ala Leu Phe Leu Val His Arg Arg Lys Lys Glu Thr Arg 
465                 470                 475                 480 


Tyr Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val Val 
                485                 490                 495     


Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr 
            500                 505                 510         


Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp 
        515                 520                 525             


Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly Glu 
    530                 535                 540                 


Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp Ser 
545                 550                 555                 560 


Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr Arg 
                565                 570                 575     


Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu Phe 
            580                 585                 590         


Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly Ser 
        595                 600                 605             


Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met Lys 
    610                 615                 620                 


His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln 
625                 630                 635                 640 


Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp Ile 
                645                 650                 655     


Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg Asp 
            660                 665                 670         


Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys Val 
        675                 680                 685             


Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg 
    690                 695                 700                 


Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser 
705                 710                 715                 720 


Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe Gly 
                725                 730                 735     


Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly 
            740                 745                 750         


Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu 
        755                 760                 765             


Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg 
    770                 775                 780                 


Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe Thr Glu Leu Arg 
785                 790                 795                 800 


Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro 
                805                 810                 815     


Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Gly Tyr Pro Glu 
            820                 825                 830         


Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln Pro Asp Pro 
        835                 840                 845             


Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val His Pro Ala Gly 
    850                 855                 860                 


Arg Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro Ala Gln Pro Ala 
865                 870                 875                 880 


Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp Gly Ala 
                885                 890                 


<210>  7
<211>  999
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  DOMAIN
<222>  (21)..(505)
<223>  Extracellular domain

<400>  7

Met Gly Pro Ala Pro Leu Pro Leu Leu Leu Gly Leu Phe Leu Pro Ala 
1               5                   10                  15      


Leu Trp Arg Arg Ala Ile Thr Glu Ala Arg Glu Glu Ala Lys Pro Tyr 
            20                  25                  30          


Pro Leu Phe Pro Gly Pro Phe Pro Gly Ser Leu Gln Thr Asp His Thr 
        35                  40                  45              


Pro Leu Leu Ser Leu Pro His Ala Ser Gly Tyr Gln Pro Ala Leu Met 
    50                  55                  60                  


Phe Ser Pro Thr Gln Pro Gly Arg Pro His Thr Gly Asn Val Ala Ile 
65                  70                  75                  80  


Pro Gln Val Thr Ser Val Glu Ser Lys Pro Leu Pro Pro Leu Ala Phe 
                85                  90                  95      


Lys His Thr Val Gly His Ile Ile Leu Ser Glu His Lys Gly Val Lys 
            100                 105                 110         


Phe Asn Cys Ser Ile Ser Val Pro Asn Ile Tyr Gln Asp Thr Thr Ile 
        115                 120                 125             


Ser Trp Trp Lys Asp Gly Lys Glu Leu Leu Gly Ala His His Ala Ile 
    130                 135                 140                 


Thr Gln Phe Tyr Pro Asp Asp Glu Val Thr Ala Ile Ile Ala Ser Phe 
145                 150                 155                 160 


Ser Ile Thr Ser Val Gln Arg Ser Asp Asn Gly Ser Tyr Ile Cys Lys 
                165                 170                 175     


Met Lys Ile Asn Asn Glu Glu Ile Val Ser Asp Pro Ile Tyr Ile Glu 
            180                 185                 190         


Val Gln Gly Leu Pro His Phe Thr Lys Gln Pro Glu Ser Met Asn Val 
        195                 200                 205             


Thr Arg Asn Thr Ala Phe Asn Leu Thr Cys Gln Ala Val Gly Pro Pro 
    210                 215                 220                 


Glu Pro Val Asn Ile Phe Trp Val Gln Asn Ser Ser Arg Val Asn Glu 
225                 230                 235                 240 


Gln Pro Glu Lys Ser Pro Ser Val Leu Thr Val Pro Gly Leu Thr Glu 
                245                 250                 255     


Met Ala Val Phe Ser Cys Glu Ala His Asn Asp Lys Gly Leu Thr Val 
            260                 265                 270         


Ser Lys Gly Val Gln Ile Asn Ile Lys Ala Ile Pro Ser Pro Pro Thr 
        275                 280                 285             


Glu Val Ser Ile Arg Asn Ser Thr Ala His Ser Ile Leu Ile Ser Trp 
    290                 295                 300                 


Val Pro Gly Phe Asp Gly Tyr Ser Pro Phe Arg Asn Cys Ser Ile Gln 
305                 310                 315                 320 


Val Lys Glu Ala Asp Pro Leu Ser Asn Gly Ser Val Met Ile Phe Asn 
                325                 330                 335     


Thr Ser Ala Leu Pro His Leu Tyr Gln Ile Lys Gln Leu Gln Ala Leu 
            340                 345                 350         


Ala Asn Tyr Ser Ile Gly Val Ser Cys Met Asn Glu Ile Gly Trp Ser 
        355                 360                 365             


Ala Val Ser Pro Trp Ile Leu Ala Ser Thr Thr Glu Gly Ala Pro Ser 
    370                 375                 380                 


Val Ala Pro Leu Asn Val Thr Val Phe Leu Asn Glu Ser Ser Asp Asn 
385                 390                 395                 400 


Val Asp Ile Arg Trp Met Lys Pro Pro Thr Lys Gln Gln Asp Gly Glu 
                405                 410                 415     


Leu Val Gly Tyr Arg Ile Ser His Val Trp Gln Ser Ala Gly Ile Ser 
            420                 425                 430         


Lys Glu Leu Leu Glu Glu Val Gly Gln Asn Gly Ser Arg Ala Arg Ile 
        435                 440                 445             


Ser Val Gln Val His Asn Ala Thr Cys Thr Val Arg Ile Ala Ala Val 
    450                 455                 460                 


Thr Arg Gly Gly Val Gly Pro Phe Ser Asp Pro Val Lys Ile Phe Ile 
465                 470                 475                 480 


Pro Ala His Gly Trp Val Asp Tyr Ala Pro Ser Ser Thr Pro Ala Pro 
                485                 490                 495     


Gly Asn Ala Asp Pro Val Leu Ile Ile Phe Gly Cys Phe Cys Gly Phe 
            500                 505                 510         


Ile Leu Ile Gly Leu Ile Leu Tyr Ile Ser Leu Ala Ile Arg Lys Arg 
        515                 520                 525             


Val Gln Glu Thr Lys Phe Gly Asn Ala Phe Thr Glu Glu Asp Ser Glu 
    530                 535                 540                 


Leu Val Val Asn Tyr Ile Ala Lys Lys Ser Phe Cys Arg Arg Ala Ile 
545                 550                 555                 560 


Glu Leu Thr Leu His Ser Leu Gly Val Ser Glu Glu Leu Gln Asn Lys 
                565                 570                 575     


Leu Glu Asp Val Val Ile Asp Arg Asn Leu Leu Ile Leu Gly Lys Ile 
            580                 585                 590         


Leu Gly Glu Gly Glu Phe Gly Ser Val Met Glu Gly Asn Leu Lys Gln 
        595                 600                 605             


Glu Asp Gly Thr Ser Leu Lys Val Ala Val Lys Thr Met Lys Leu Asp 
    610                 615                 620                 


Asn Ser Ser Gln Arg Glu Ile Glu Glu Phe Leu Ser Glu Ala Ala Cys 
625                 630                 635                 640 


Met Lys Asp Phe Ser His Pro Asn Val Ile Arg Leu Leu Gly Val Cys 
                645                 650                 655     


Ile Glu Met Ser Ser Gln Gly Ile Pro Lys Pro Met Val Ile Leu Pro 
            660                 665                 670         


Phe Met Lys Tyr Gly Asp Leu His Thr Tyr Leu Leu Tyr Ser Arg Leu 
        675                 680                 685             


Glu Thr Gly Pro Lys His Ile Pro Leu Gln Thr Leu Leu Lys Phe Met 
    690                 695                 700                 


Val Asp Ile Ala Leu Gly Met Glu Tyr Leu Ser Asn Arg Asn Phe Leu 
705                 710                 715                 720 


His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Arg Asp Asp Met Thr 
                725                 730                 735     


Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Ser Gly Asp 
            740                 745                 750         


Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala 
        755                 760                 765             


Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp 
    770                 775                 780                 


Ala Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg Gly Met Thr Pro 
785                 790                 795                 800 


Tyr Pro Gly Val Gln Asn His Glu Met Tyr Asp Tyr Leu Leu His Gly 
                805                 810                 815     


His Arg Leu Lys Gln Pro Glu Asp Cys Leu Asp Glu Leu Tyr Glu Ile 
            820                 825                 830         


Met Tyr Ser Cys Trp Arg Thr Asp Pro Leu Asp Arg Pro Thr Phe Ser 
        835                 840                 845             


Val Leu Arg Leu Gln Leu Glu Lys Leu Leu Glu Ser Leu Pro Asp Val 
    850                 855                 860                 


Arg Asn Gln Ala Asp Val Ile Tyr Val Asn Thr Gln Leu Leu Glu Ser 
865                 870                 875                 880 


Ser Glu Gly Leu Ala Gln Gly Ser Thr Leu Ala Pro Leu Asp Leu Asn 
                885                 890                 895     


Ile Asp Pro Asp Ser Ile Ile Ala Ser Cys Thr Pro Arg Ala Ala Ile 
            900                 905                 910         


Ser Val Val Thr Ala Glu Val His Asp Ser Lys Pro His Glu Gly Arg 
        915                 920                 925             


Tyr Ile Leu Asn Gly Gly Ser Glu Glu Trp Glu Asp Leu Thr Ser Ala 
    930                 935                 940                 


Pro Ser Ala Ala Val Thr Ala Glu Lys Asn Ser Val Leu Pro Gly Glu 
945                 950                 955                 960 


Arg Leu Val Arg Asn Gly Val Ser Trp Ser His Ser Ser Met Leu Pro 
                965                 970                 975     


Leu Gly Ser Ser Leu Pro Asp Glu Leu Leu Phe Ala Asp Asp Ser Ser 
            980                 985                 990         


Glu Gly Ser Glu Val Leu Met 
        995                 


<210>  8
<211>  880
<212>  PRT
<213>  Mus musculus


<220>
<221>  SIGNAL
<222>  (1)..(30)

<220>
<221>  DOMAIN
<222>  (31)..(419)
<223>  Extracellular domain

<400>  8

Met Ala Leu Arg Arg Ser Met Gly Trp Pro Gly Leu Arg Pro Leu Leu 
1               5                   10                  15      


Leu Ala Gly Leu Ala Ser Leu Leu Leu Pro Gly Ser Ala Ala Ala Gly 
            20                  25                  30          


Leu Lys Leu Met Gly Ala Pro Val Lys Met Thr Val Ser Gln Gly Gln 
        35                  40                  45              


Pro Val Lys Leu Asn Cys Ser Val Glu Gly Met Glu Asp Pro Asp Ile 
    50                  55                  60                  


His Trp Met Lys Asp Gly Thr Val Val Gln Asn Ala Ser Gln Val Ser 
65                  70                  75                  80  


Ile Ser Ile Ser Glu His Ser Trp Ile Gly Leu Leu Ser Leu Lys Ser 
                85                  90                  95      


Val Glu Arg Ser Asp Ala Gly Leu Tyr Trp Cys Gln Val Lys Asp Gly 
            100                 105                 110         


Glu Glu Thr Lys Ile Ser Gln Ser Val Trp Leu Thr Val Glu Gly Val 
        115                 120                 125             


Pro Phe Phe Thr Val Glu Pro Lys Asp Leu Ala Val Pro Pro Asn Ala 
    130                 135                 140                 


Pro Phe Gln Leu Ser Cys Glu Ala Val Gly Pro Pro Glu Pro Val Thr 
145                 150                 155                 160 


Ile Tyr Trp Trp Arg Gly Leu Thr Lys Val Gly Gly Pro Ala Pro Ser 
                165                 170                 175     


Pro Ser Val Leu Asn Val Thr Gly Val Thr Gln Arg Thr Glu Phe Ser 
            180                 185                 190         


Cys Glu Ala Arg Asn Ile Lys Gly Leu Ala Thr Ser Arg Pro Ala Ile 
        195                 200                 205             


Val Arg Leu Gln Ala Pro Pro Ala Ala Pro Phe Asn Thr Thr Val Thr 
    210                 215                 220                 


Thr Ile Ser Ser Tyr Asn Ala Ser Val Ala Trp Val Pro Gly Ala Asp 
225                 230                 235                 240 


Gly Leu Ala Leu Leu His Ser Cys Thr Val Gln Val Ala His Ala Pro 
                245                 250                 255     


Gly Glu Trp Glu Ala Leu Ala Val Val Val Pro Val Pro Pro Phe Thr 
            260                 265                 270         


Cys Leu Leu Arg Asn Leu Ala Pro Ala Thr Asn Tyr Ser Leu Arg Val 
        275                 280                 285             


Arg Cys Ala Asn Ala Leu Gly Pro Ser Pro Tyr Gly Asp Trp Val Pro 
    290                 295                 300                 


Phe Gln Thr Lys Gly Leu Ala Pro Ala Arg Ala Pro Gln Asn Phe His 
305                 310                 315                 320 


Ala Ile Arg Thr Asp Ser Gly Leu Ile Leu Glu Trp Glu Glu Val Ile 
                325                 330                 335     


Pro Glu Asp Pro Gly Glu Gly Pro Leu Gly Pro Tyr Lys Leu Ser Trp 
            340                 345                 350         


Val Gln Glu Asn Gly Thr Gln Asp Glu Leu Met Val Glu Gly Thr Arg 
        355                 360                 365             


Ala Asn Leu Thr Asp Trp Asp Pro Gln Lys Asp Leu Ile Leu Arg Val 
    370                 375                 380                 


Cys Ala Ser Asn Ala Ile Gly Asp Gly Pro Trp Ser Gln Pro Leu Val 
385                 390                 395                 400 


Val Ser Ser His Asp His Ala Gly Arg Gln Gly Pro Pro His Ser Arg 
                405                 410                 415     


Thr Ser Trp Val Pro Val Val Leu Gly Val Leu Thr Ala Leu Ile Thr 
            420                 425                 430         


Ala Ala Ala Leu Ala Leu Ile Leu Leu Arg Lys Arg Arg Lys Glu Thr 
        435                 440                 445             


Arg Phe Gly Gln Ala Phe Asp Ser Val Met Ala Arg Gly Glu Pro Ala 
    450                 455                 460                 


Val His Phe Arg Ala Ala Arg Ser Phe Asn Arg Glu Arg Pro Glu Arg 
465                 470                 475                 480 


Ile Glu Ala Thr Leu Asp Ser Leu Gly Ile Ser Asp Glu Leu Lys Glu 
                485                 490                 495     


Lys Leu Glu Asp Val Leu Ile Pro Glu Gln Gln Phe Thr Leu Gly Arg 
            500                 505                 510         


Met Leu Gly Lys Gly Glu Phe Gly Ser Val Arg Glu Ala Gln Leu Lys 
        515                 520                 525             


Gln Glu Asp Gly Ser Phe Val Lys Val Ala Val Lys Met Leu Lys Ala 
    530                 535                 540                 


Asp Ile Ile Ala Ser Ser Asp Ile Glu Glu Phe Leu Arg Glu Ala Ala 
545                 550                 555                 560 


Cys Met Lys Glu Phe Asp His Pro His Val Ala Lys Leu Val Gly Val 
                565                 570                 575     


Ser Leu Arg Ser Arg Ala Lys Gly Arg Leu Pro Ile Pro Met Val Ile 
            580                 585                 590         


Leu Pro Phe Met Lys His Gly Asp Leu His Ala Phe Leu Leu Ala Ser 
        595                 600                 605             


Arg Ile Gly Glu Asn Pro Phe Asn Leu Pro Leu Gln Thr Leu Val Arg 
    610                 615                 620                 


Phe Met Val Asp Ile Ala Cys Gly Met Glu Tyr Leu Ser Ser Arg Asn 
625                 630                 635                 640 


Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Ala Glu Asp 
                645                 650                 655     


Met Thr Val Cys Val Ala Asp Phe Gly Leu Ser Arg Lys Ile Tyr Ser 
            660                 665                 670         


Gly Asp Tyr Tyr Arg Gln Gly Cys Ala Ser Lys Leu Pro Val Lys Trp 
        675                 680                 685             


Leu Ala Leu Glu Ser Leu Ala Asp Asn Leu Tyr Thr Val His Ser Asp 
    690                 695                 700                 


Val Trp Ala Phe Gly Val Thr Met Trp Glu Ile Met Thr Arg Gly Gln 
705                 710                 715                 720 


Thr Pro Tyr Ala Gly Ile Glu Asn Ala Glu Ile Tyr Asn Tyr Leu Ile 
                725                 730                 735     


Gly Gly Asn Arg Leu Lys Gln Pro Pro Glu Cys Met Glu Glu Val Tyr 
            740                 745                 750         


Asp Leu Met Tyr Gln Cys Trp Ser Ala Asp Pro Lys Gln Arg Pro Ser 
        755                 760                 765             


Phe Thr Cys Leu Arg Met Glu Leu Glu Asn Ile Leu Gly His Leu Ser 
    770                 775                 780                 


Val Leu Ser Thr Ser Gln Asp Pro Leu Tyr Ile Asn Ile Glu Arg Ala 
785                 790                 795                 800 


Glu Gln Pro Thr Glu Ser Gly Ser Pro Glu Val His Cys Gly Glu Arg 
                805                 810                 815     


Ser Ser Ser Glu Ala Gly Asp Gly Ser Gly Val Gly Ala Val Gly Gly 
            820                 825                 830         


Ile Pro Ser Asp Ser Arg Tyr Ile Phe Ser Pro Gly Gly Leu Ser Glu 
        835                 840                 845             


Ser Pro Gly Gln Leu Glu Gln Gln Pro Glu Ser Pro Leu Asn Glu Asn 
    850                 855                 860                 


Gln Arg Leu Leu Leu Leu Gln Gln Gly Leu Leu Pro His Ser Ser Cys 
865                 870                 875                 880 


<210>  9
<211>  409
<212>  PRT
<213>  Macaca fascicularis


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  DOMAIN
<222>  (21)..(409)
<223>  extracellular domain

<400>  9

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ala Gly Leu Lys Leu Met Gly Ala Pro Val Lys Leu 
            20                  25                  30          


Thr Val Ser Gln Gly Gln Pro Val Lys Leu Asn Cys Ser Val Glu Gly 
        35                  40                  45              


Met Glu Glu Pro Asp Ile Gln Trp Val Lys Asp Gly Ala Val Val Gln 
    50                  55                  60                  


Asn Leu Asp Gln Leu Tyr Ile Pro Val Ser Glu Gln His Trp Ile Gly 
65                  70                  75                  80  


Phe Leu Ser Leu Lys Ser Ala Glu Arg Ser Asp Ala Gly Arg Tyr Trp 
                85                  90                  95      


Cys Gln Val Glu Asp Gly Gly Glu Thr Glu Ile Ser Gln Pro Val Trp 
            100                 105                 110         


Leu Thr Val Glu Gly Val Pro Phe Phe Thr Val Glu Pro Lys Asp Leu 
        115                 120                 125             


Ala Val Pro Pro Asn Ala Pro Phe Gln Leu Ser Cys Glu Ala Val Gly 
    130                 135                 140                 


Pro Pro Glu Pro Val Thr Ile Val Trp Trp Arg Gly Thr Thr Lys Ile 
145                 150                 155                 160 


Gly Gly Pro Ala Pro Ser Pro Ser Val Leu Asn Val Thr Gly Val Thr 
                165                 170                 175     


Gln Ser Thr Met Phe Ser Cys Glu Ala His Asn Leu Lys Gly Leu Ala 
            180                 185                 190         


Ser Ser Arg Thr Ala Thr Val His Leu Gln Ala Leu Pro Ala Ala Pro 
        195                 200                 205             


Phe Asn Val Thr Val Thr Lys Leu Ser Ser Ser Asn Ala Ser Val Ala 
    210                 215                 220                 


Trp Met Pro Gly Ala Asp Gly Arg Ala Leu Leu Gln Ser Cys Thr Val 
225                 230                 235                 240 


Gln Val Thr Gln Ala Pro Gly Gly Trp Glu Val Leu Ala Val Val Val 
                245                 250                 255     


Pro Val Pro Pro Phe Thr Cys Leu Leu Arg Asp Leu Val Pro Ala Thr 
            260                 265                 270         


Asn Tyr Ser Leu Arg Val Arg Cys Ala Asn Ala Leu Gly Pro Ser Pro 
        275                 280                 285             


Tyr Ala Asp Trp Val Pro Phe Gln Thr Lys Gly Leu Ala Pro Ala Ser 
    290                 295                 300                 


Ala Pro Gln Asn Leu His Ala Ile Arg Thr Asp Ser Gly Leu Ile Leu 
305                 310                 315                 320 


Glu Trp Glu Glu Val Ile Pro Glu Gly Pro Leu Glu Gly Pro Leu Gly 
                325                 330                 335     


Pro Tyr Lys Leu Ser Trp Val Gln Asp Asn Gly Thr Gln Asp Glu Leu 
            340                 345                 350         


Thr Val Glu Gly Thr Arg Ala Asn Leu Thr Gly Trp Asp Pro Gln Lys 
        355                 360                 365             


Asp Leu Ile Val Arg Val Cys Val Ser Asn Ala Val Gly Cys Gly Pro 
    370                 375                 380                 


Trp Ser Gln Pro Leu Val Val Ser Ser His Asp His Ala Gly Gln Gln 
385                 390                 395                 400 


Gly Pro Pro His Ser Arg Thr Ser Trp 
                405                 


<210>  10
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region of IGX2410

<400>  10

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Glu Lys Arg Ala Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Met Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Gln Glu Arg Asn Gly Asn Tyr 
                85                  90                  95      


Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  11
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region of IGX2410

<400>  11

Glu Val Gln Leu Val Gln Ser Gly Ala Asp Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Leu Thr Ile Ser Cys Gln Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Lys Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gln Ile Val Pro Arg Ala Ser Arg Thr Asn Tyr Gly Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Arg Ser Thr Ala Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Arg Ser Leu Glu Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Pro Tyr Phe Gln Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr 
            100                 105                 110         


Gln His Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L1 according to Chothia, AbM or Kabat definition

<400>  12

Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala Tyr 
1               5                   10      


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L1 according to Contact definition

<400>  13

Lys Lys Tyr Ala Tyr Trp Tyr 
1               5           


<210>  14
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L1 according to IMGT definition

<400>  14

Ala Leu Pro Lys Lys Tyr 
1               5       


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L2 of IGX2410 according to Chothia, AbM or Kabat 
       definition

<400>  15

Glu Asp Glu Lys Arg Ala Ser 
1               5           


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L2 of IGX2410 according to Contact definition

<400>  16

Leu Val Ile Tyr Glu Asp Glu Lys Arg Ala 
1               5                   10  


<210>  17
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L3 of IGX2410 according to Chothia, AbM, Kabat or
       IMGT definition

<400>  17

Tyr Ser Gln Glu Arg Asn Gly Asn Tyr Ala Val 
1               5                   10      


<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L3 of IGX2410 according to Contact definition

<400>  18

Tyr Ser Gln Glu Arg Asn Gly Asn Tyr Ala 
1               5                   10  


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H1 according to Chothia definition

<400>  19

Gly Tyr Thr Phe Thr Asp Tyr 
1               5           


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H1 according to AbM definition

<400>  20

Gly Tyr Thr Phe Thr Asp Tyr Trp Ile Ser 
1               5                   10  


<210>  21
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H1 according to Kabat definition

<400>  21

Asp Tyr Trp Ile Ser 
1               5   


<210>  22
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H1 according to Contact definition

<400>  22

Thr Asp Tyr Trp Ile Ser 
1               5       


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H1 according to IMGT definition

<400>  23

Gly Tyr Thr Phe Thr Asp Tyr Trp 
1               5               


<210>  24
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2410 according to Chothia definition

<400>  24

Val Pro Arg Ala Ser Arg 
1               5       


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2410 according to AbM definition

<400>  25

Gln Ile Val Pro Arg Ala Ser Arg Thr Asn 
1               5                   10  


<210>  26
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2410 according to Kabat definition

<400>  26

Gln Ile Val Pro Arg Ala Ser Arg Thr Asn Tyr Gly Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  27
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2410 according to Contact definition

<400>  27

Trp Met Gly Gln Ile Val Pro Arg Ala Ser Arg Thr Asn 
1               5                   10              


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2410 according to IMGT definition

<400>  28

Ile Val Pro Arg Ala Ser Arg Thr 
1               5               


<210>  29
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H3 of IGX2410 according to Chothia, AbM or Kabat 
       definition

<400>  29

Pro Tyr Phe Gln Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr Gln His 
1               5                   10                  15      


<210>  30
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H3 of IGX2410 according to Contact definition

<400>  30

Val Arg Pro Tyr Phe Gln Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr 
1               5                   10                  15      


Gln 
    


<210>  31
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H3 of IGX2410 according to IMGT definition

<400>  31

Val Arg Pro Tyr Phe Gln Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr 
1               5                   10                  15      


Gln His 
        


<210>  32
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region of IGX2414

<400>  32

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Trp Lys Arg Ala Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Met Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Gln Glu Arg Lys Gly Asn Tyr 
                85                  90                  95      


Phe Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  33
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region of IGX2414

<400>  33

Glu Val Gln Leu Val Gln Ser Gly Ala Asp Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Leu Thr Ile Ser Cys Gln Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Lys Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gln Ile Asn Arg His Ala Ser Asn Thr Met Tyr Gly Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Arg Ser Thr Ala Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Arg Ser Leu Glu Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Ser Gly Gly Ala Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr 
            100                 105                 110         


Gln His Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L2 of IGX2414 according to Chothia, AbM or Kabat 
       definition

<400>  34

Glu Asp Trp Lys Arg Ala Ser 
1               5           


<210>  35
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L2 of IGX2414 according to Contact definition

<400>  35

Leu Val Ile Tyr Glu Asp Trp Lys Arg Ala 
1               5                   10  


<210>  36
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L3 of IGX2414 according to Chothia, AbM, Kabat or
       IMGT definition

<400>  36

Tyr Ser Gln Glu Arg Lys Gly Asn Tyr Phe Val 
1               5                   10      


<210>  37
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L3 of IGX2414 according to Contact definition

<400>  37

Tyr Ser Gln Glu Arg Lys Gly Asn Tyr Phe 
1               5                   10  


<210>  38
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2414 according to Chothia definition

<400>  38

Asn Arg His Ala Ser Asn 
1               5       


<210>  39
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2414 according to AbM definition

<400>  39

Gln Ile Asn Arg His Ala Ser Asn Thr Met 
1               5                   10  


<210>  40
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2414 according to Kabat definition

<400>  40

Gln Ile Asn Arg His Ala Ser Asn Thr Met Tyr Gly Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  41
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2414 according to Contact definition

<400>  41

Trp Met Gly Gln Ile Asn Arg His Ala Ser Asn Thr Met 
1               5                   10              


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2414 according to IMGT definition

<400>  42

Ile Asn Arg His Ala Ser Asn Thr 
1               5               


<210>  43
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H3 of IGX2414 according to Chothia, AbM or Kabat 
       definition

<400>  43

Ser Gly Gly Ala Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr Gln His 
1               5                   10                  15      


<210>  44
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H3 of IGX2414 according to Contact definition

<400>  44

Val Arg Ser Gly Gly Ala Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr 
1               5                   10                  15      


Gln 
    


<210>  45
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H3 of IGX2414 according to IMGT definition

<400>  45

Val Arg Ser Gly Gly Ala Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr 
1               5                   10                  15      


Gln His 
        


<210>  46
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region of IGX2709

<400>  46

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Lys Lys Arg Val Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Met Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Leu Ala Val Asp Gly Asn Tyr 
                85                  90                  95      


Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  47
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region of IGX2709

<400>  47

Glu Val Gln Leu Val Gln Ser Gly Ala Asp Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Leu Thr Ile Ser Cys Gln Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Lys Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Ile Ser Arg Asn Gly Ser Thr Thr Tyr Tyr Gly Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Arg Ser Thr Ala Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Arg Ser Leu Glu Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Ser Gly Gly Leu Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr 
            100                 105                 110         


Gln His Trp Gly Pro Gly Thr Leu Val Pro Val Ser Ser Val Asp 
        115                 120                 125         


<210>  48
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L2 of IGX2709 according to Chothia, AbM or Kabat 
       definition

<400>  48

Glu Asp Lys Lys Arg Val Ser 
1               5           


<210>  49
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L2 of IGX2709 according to Contact definition

<400>  49

Leu Val Ile Tyr Glu Asp Lys Lys Arg Val 
1               5                   10  


<210>  50
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L3 of IGX2709 according to Chothia, AbM, Kabat or
       IMGT definition

<400>  50

Tyr Ser Leu Ala Val Asp Gly Asn Tyr Gly Val 
1               5                   10      


<210>  51
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L3 of IGX2709 according to Contact definition

<400>  51

Tyr Ser Leu Ala Val Asp Gly Asn Tyr Gly 
1               5                   10  


<210>  52
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2709 according to Chothia definition

<400>  52

Ser Arg Asn Gly Ser Thr 
1               5       


<210>  53
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2709 according to AbM definition

<400>  53

Ala Ile Ser Arg Asn Gly Ser Thr Thr Tyr 
1               5                   10  


<210>  54
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2709 according to Kabat definition

<400>  54

Ala Ile Ser Arg Asn Gly Ser Thr Thr Tyr Tyr Gly Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  55
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2709 according to Contact definition

<400>  55

Trp Met Gly Ala Ile Ser Arg Asn Gly Ser Thr Thr Tyr 
1               5                   10              


<210>  56
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2709 according to IMGT definition

<400>  56

Ile Ser Arg Asn Gly Ser Thr Thr 
1               5               


<210>  57
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H3 of IGX2709 according to Chothia, AbM or Kabat 
       definition

<400>  57

Ser Gly Gly Leu Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr Gln His 
1               5                   10                  15      


<210>  58
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H3 of IGX2709 according to Contact definition

<400>  58

Val Arg Ser Gly Gly Leu Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr 
1               5                   10                  15      


Gln 
    


<210>  59
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H3 of IGX2709 according to IMGT definition

<400>  59

Val Arg Ser Gly Gly Leu Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr 
1               5                   10                  15      


Gln His 
        


<210>  60
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region of IGX2710

<400>  60

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Met Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Gln Asn Pro Gln Gly Asn Tyr 
                85                  90                  95      


Phe Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  61
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region of IGX2710

<400>  61

Glu Val Gln Leu Val Gln Ser Gly Ala Asp Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Leu Thr Ile Ser Cys Gln Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Lys Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Lys Tyr Ala Ser Trp Thr Arg Tyr Gly Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Arg Ser Thr Ala Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Arg Ser Leu Glu Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Ser Gly Gly Leu Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr 
            100                 105                 110         


Gln His Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  62
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L2 of IGX2710 according to Chothia, AbM or Kabat 
       definition

<400>  62

Glu Asp Ser Lys Arg Pro Ser 
1               5           


<210>  63
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L2 of IGX2710 according to Contact definition

<400>  63

Leu Val Ile Tyr Glu Asp Ser Lys Arg Pro 
1               5                   10  


<210>  64
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L3 of IGX2710 according to Chothia, AbM, Kabat or
       IMGT definition

<400>  64

Tyr Ser Gln Asn Pro Gln Gly Asn Tyr Phe Val 
1               5                   10      


<210>  65
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L3 of IGX2710 according to Contact definition

<400>  65

Tyr Ser Gln Asn Pro Gln Gly Asn Tyr Phe 
1               5                   10  


<210>  66
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2710 according to Chothia definition

<400>  66

Asn Lys Tyr Ala Ser Trp 
1               5       


<210>  67
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2710 according to AbM definition

<400>  67

Val Ile Asn Lys Tyr Ala Ser Trp Thr Arg 
1               5                   10  


<210>  68
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2710 according to Kabat definition

<400>  68

Val Ile Asn Lys Tyr Ala Ser Trp Thr Arg Tyr Gly Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  69
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2710 according to Contact definition

<400>  69

Trp Met Gly Val Ile Asn Lys Tyr Ala Ser Trp Thr Arg 
1               5                   10              


<210>  70
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2710 according to IMGT definition

<400>  70

Ile Asn Lys Tyr Ala Ser Trp Thr 
1               5               


<210>  71
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H3 of IGX2710 according to Chothia, AbM or Kabat 
       definition

<400>  71

Ser Gly Gly Leu Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr Gln His 
1               5                   10                  15      


<210>  72
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H3 of IGX2710 according to Contact definition

<400>  72

Val Arg Ser Gly Gly Leu Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr 
1               5                   10                  15      


Gln 
    


<210>  73
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H3 of IGX2710 according to IMGT definition

<400>  73

Val Arg Ser Gly Gly Leu Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr 
1               5                   10                  15      


Gln His 
        


<210>  74
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region of IGX2717

<400>  74

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Asn Lys Arg Gly Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Met Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Lys Ser Pro Glu Gly Asn Tyr 
                85                  90                  95      


Met Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  75
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region of IGX2717

<400>  75

Glu Val Gln Leu Val Gln Ser Gly Ala Asp Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Leu Thr Ile Ser Cys Gln Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Lys Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Phe Leu Pro Pro Ser Thr Thr Val Tyr Gly Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Arg Ser Thr Ala Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Arg Ser Leu Glu Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gln Thr Arg Leu Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr 
            100                 105                 110         


Gln His Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  76
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L2 of IGX2717 according to Chothia, AbM or Kabat 
       definition

<400>  76

Glu Asp Asn Lys Arg Gly Ser 
1               5           


<210>  77
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L2 of IGX2717 according to Contact definition

<400>  77

Leu Val Ile Tyr Glu Asp Asn Lys Arg Gly 
1               5                   10  


<210>  78
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of CDR-L3 of IGX2717 according to Chothia, AbM, Kabat or
       IMGT definition

<400>  78

Tyr Ser Lys Ser Pro Glu Gly Asn Tyr Met Val 
1               5                   10      


<210>  79
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L3 of IGX2717 according to Contact definition

<400>  79

Tyr Ser Lys Ser Pro Glu Gly Asn Tyr Met 
1               5                   10  


<210>  80
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of CDR-H2 of IGX2717 according to Chothia definition

<400>  80

Phe Leu Pro Pro Ser Thr 
1               5       


<210>  81
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2717 according to AbM definition

<400>  81

Glu Ile Phe Leu Pro Pro Ser Thr Thr Val 
1               5                   10  


<210>  82
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2717 according to Kabat definition

<400>  82

Glu Ile Phe Leu Pro Pro Ser Thr Thr Val Tyr Gly Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  83
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2717 according to Contact definition

<400>  83

Trp Met Gly Glu Ile Phe Leu Pro Pro Ser Thr Thr Val 
1               5                   10              


<210>  84
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2717 according to IMGT definition

<400>  84

Ile Phe Leu Pro Pro Ser Thr Thr 
1               5               


<210>  85
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H3 of IGX2717 according to Chothia, AbM or Kabat 
       definition

<400>  85

Gln Thr Arg Leu Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr Gln His 
1               5                   10                  15      


<210>  86
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H3 of IGX2717 according to Contact definition

<400>  86

Val Arg Gln Thr Arg Leu Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr 
1               5                   10                  15      


Gln 
    


<210>  87
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H3 of IGX2717 according to IMGT definition

<400>  87

Val Arg Gln Thr Arg Leu Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr 
1               5                   10                  15      


Gln His 
        


<210>  88
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region of IGX2411

<400>  88

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Ser Lys Arg Ser Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Met Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Ala Asn Gln Arg Gly Asn Tyr 
                85                  90                  95      


Met Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  89
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region of IGX2411

<400>  89

Glu Val Gln Leu Val Gln Ser Gly Ala Asp Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Leu Thr Ile Ser Cys Gln Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Lys Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Thr Arg Ser Ser Ser Arg Thr His Tyr Gly Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Arg Ser Thr Ala Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Arg Ser Leu Glu Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Tyr Thr His Leu Arg Thr Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  90
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of CDR-L2 of IGX2411 according to Chothia, AbM or Kabat 
       definition

<400>  90

Glu Asp Ser Lys Arg Ser Ser 
1               5           


<210>  91
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of CDR-L2 of IGX2411 according to Contact definition

<400>  91

Leu Val Ile Tyr Glu Asp Ser Lys Arg Ser 
1               5                   10  


<210>  92
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of CDR-L3 of IGX2411 acording to Chothia, AbM, Kabat or 
       IMGT definition

<400>  92

Tyr Ser Ala Asn Gln Arg Gly Asn Tyr Met Val 
1               5                   10      


<210>  93
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L3 of IGX2411 according to Contact definition

<400>  93

Tyr Ser Ala Asn Gln Arg Gly Asn Tyr Met 
1               5                   10  


<210>  94
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of CDR-H2 of IGX2411 according to Chothia definition

<400>  94

Thr Arg Ser Ser Ser Arg 
1               5       


<210>  95
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of CDR-H2 of IGX2411 according to AbM definition

<400>  95

Ser Ile Thr Arg Ser Ser Ser Arg Thr His 
1               5                   10  


<210>  96
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2411 according to Kabat definition

<400>  96

Ser Ile Thr Arg Ser Ser Ser Arg Thr His Tyr Gly Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  97
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2411 according to Contact definition

<400>  97

Trp Met Gly Ser Ile Thr Arg Ser Ser Ser Arg Thr His 
1               5                   10              


<210>  98
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of CDR-H2 of IGX2411 according to IMGT definition

<400>  98

Ile Thr Arg Ser Ser Ser Arg Thr 
1               5               


<210>  99
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H3 of IGX2411 according to Chothia, AbM or Kabat 
       definition

<400>  99

Gly Tyr Thr His Leu Arg Thr 
1               5           


<210>  100
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of CDR-H3 of IGX2411 according to Contact definition

<400>  100

Val Arg Gly Tyr Thr His Leu Arg 
1               5               


<210>  101
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of CDR-H3 of IGX2411 according to IMGT definition

<400>  101

Val Arg Gly Tyr Thr His Leu Arg Thr 
1               5                   


<210>  102
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region of IGX2412

<400>  102

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Ala Lys Arg Val Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Met Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Ala Ser Ala Asn Gly Asn Tyr 
                85                  90                  95      


Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  103
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region of IGX2412

<400>  103

Glu Val Gln Leu Val Gln Ser Gly Ala Asp Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Leu Thr Ile Ser Cys Gln Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Lys Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Arg Pro Leu Leu Ser His Thr Met Tyr Gly Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Arg Ser Thr Ala Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Arg Ser Leu Glu Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Ser Trp Leu Ala Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr 
            100                 105                 110         


Gln His Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  104
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L2 of IGX2412 according to Chothia, AbM or Kabat 
       definition

<400>  104

Glu Asp Ala Lys Arg Val Ser 
1               5           


<210>  105
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of CDR-L2 of IGX2412 according to Contact definition

<400>  105

Leu Val Ile Tyr Glu Asp Ala Lys Arg Val 
1               5                   10  


<210>  106
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of CDR-L3 of IGX2412 according to Chothia, AbM, Kabat or
       IMGT definition

<400>  106

Tyr Ser Ala Ser Ala Asn Gly Asn Tyr Arg Val 
1               5                   10      


<210>  107
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of CDR-L3 of IGX2412 according to Contact definition

<400>  107

Tyr Ser Ala Ser Ala Asn Gly Asn Tyr Arg 
1               5                   10  


<210>  108
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2412 according to Chothia definition

<400>  108

Arg Pro Leu Leu Ser His 
1               5       


<210>  109
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of CDR-H2 of IGX2412 according to AbM definition

<400>  109

Arg Ile Arg Pro Leu Leu Ser His Thr Met 
1               5                   10  


<210>  110
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of CDR-H2 of IGX2412 according to Kabat definition

<400>  110

Arg Ile Arg Pro Leu Leu Ser His Thr Met Tyr Gly Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  111
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of CDR-H2 of IGX2412 according to Contact definition

<400>  111

Trp Met Gly Arg Ile Arg Pro Leu Leu Ser His Thr Met 
1               5                   10              


<210>  112
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of CDR-H2 of IGX2412 according to IMGT definition

<400>  112

Ile Arg Pro Leu Leu Ser His Thr 
1               5               


<210>  113
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of CDR-H3 of IGX2412 according to Chothia, AbM or Kabat 
       definition

<400>  113

Ser Trp Leu Ala Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr Gln His 
1               5                   10                  15      


<210>  114
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of CDR-H3 of IGX2412 according to Contact definition

<400>  114

Val Arg Ser Trp Leu Ala Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr 
1               5                   10                  15      


Gln 
    


<210>  115
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of CDR-H3 of IGX2412 according to IMGT definition

<400>  115

Val Arg Ser Trp Leu Ala Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr 
1               5                   10                  15      


Gln His 
        


<210>  116
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region of IGX2413

<400>  116

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Asp Lys Arg Leu Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Met Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Thr Glu Ile Asn Gly Asn Tyr 
                85                  90                  95      


Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  117
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region of IGX2413

<400>  117

Glu Val Gln Leu Val Gln Ser Gly Ala Asp Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Leu Thr Ile Ser Cys Gln Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Lys Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile His Thr Tyr Gln Ser Ser Thr Arg Tyr Gly Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Arg Ser Thr Ala Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Arg Ser Leu Glu Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg His His Ser Thr Thr Thr Ala Asn Pro Tyr Ser Ser Trp Gly 
            100                 105                 110         


Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  118
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L2 of IGX2413 according to Chothia, AbM or Kabat 
       definition

<400>  118

Glu Asp Asp Lys Arg Leu Ser 
1               5           


<210>  119
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L2 of IGX2413 according to Contact definition

<400>  119

Leu Val Ile Tyr Glu Asp Asp Lys Arg Leu 
1               5                   10  


<210>  120
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L3 of IGX2413 according to Chothia, AbM, Kabat or
       IMGT definition

<400>  120

Tyr Ser Thr Glu Ile Asn Gly Asn Tyr Ala Val 
1               5                   10      


<210>  121
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L3 of IGX2413 according to Contact definition

<400>  121

Tyr Ser Thr Glu Ile Asn Gly Asn Tyr Ala 
1               5                   10  


<210>  122
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2413 according to Chothia definition

<400>  122

His Thr Tyr Gln Ser Ser 
1               5       


<210>  123
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2413 according to AbM definition

<400>  123

Arg Ile His Thr Tyr Gln Ser Ser Thr Arg 
1               5                   10  


<210>  124
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2413 according to Kabat definition

<400>  124

Arg Ile His Thr Tyr Gln Ser Ser Thr Arg Tyr Gly Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  125
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2413 according to Contact definition

<400>  125

Trp Met Gly Arg Ile His Thr Tyr Gln Ser Ser Thr Arg 
1               5                   10              


<210>  126
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2413 according to IMGT definition

<400>  126

Ile His Thr Tyr Gln Ser Ser Thr 
1               5               


<210>  127
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H3 of IGX2413 according to Chothia, AbM or Kabat 
       definition

<400>  127

His His Ser Thr Thr Thr Ala Asn Pro Tyr Ser Ser 
1               5                   10          


<210>  128
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H3 of IGX2413 according to Contact definition

<400>  128

Val Arg His His Ser Thr Thr Thr Ala Asn Pro Tyr Ser 
1               5                   10              


<210>  129
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H3 of IGX2413 according to IMGT definition

<400>  129

Val Arg His His Ser Thr Thr Thr Ala Asn Pro Tyr Ser Ser 
1               5                   10                  


<210>  130
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region of IGX2415

<400>  130

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Lys Lys Arg Ile Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Met Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Thr Ser Thr Gly Gly Asn Tyr 
                85                  90                  95      


Met Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  131
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region of IGX2415

<400>  131

Glu Val Gln Leu Val Gln Ser Gly Ala Asp Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Leu Thr Ile Ser Cys Gln Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Lys Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gln Ile Arg Gly Pro Ala Ser Ala Thr His Tyr Gly Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Arg Ser Thr Ala Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Arg Ser Leu Glu Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg His Gln Gln Gln Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr 
            100                 105                 110         


Gln His Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  132
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L2 of IGX2415 according to Chothia, AbM or Kabat 
       definition

<400>  132

Glu Asp Lys Lys Arg Ile Ser 
1               5           


<210>  133
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L2 of IGX2415 according to Contact definition

<400>  133

Leu Val Ile Tyr Glu Asp Lys Lys Arg Ile 
1               5                   10  


<210>  134
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L3 of IGX2415 according to Chothia, AbM, Kabat or
       IMGT definition

<400>  134

Tyr Ser Thr Ser Thr Gly Gly Asn Tyr Met Val 
1               5                   10      


<210>  135
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L3 of IGX2415 according to Contact definition

<400>  135

Tyr Ser Thr Ser Thr Gly Gly Asn Tyr Met 
1               5                   10  


<210>  136
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2415 according to Chothia definition

<400>  136

Arg Gly Pro Ala Ser Ala 
1               5       


<210>  137
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2415 according to AbM definition

<400>  137

Gln Ile Arg Gly Pro Ala Ser Ala Thr His 
1               5                   10  


<210>  138
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2415 according to Kabat definition

<400>  138

Gln Ile Arg Gly Pro Ala Ser Ala Thr His Tyr Gly Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  139
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2415 according to Contact definition

<400>  139

Trp Met Gly Gln Ile Arg Gly Pro Ala Ser Ala Thr His 
1               5                   10              


<210>  140
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2415 according to IMGT definition

<400>  140

Ile Arg Gly Pro Ala Ser Ala Thr 
1               5               


<210>  141
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H3 of IGX2415 according to Chothia, AbM or Kabat 
       definition

<400>  141

His Gln Gln Gln Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr Gln His 
1               5                   10                  15      


<210>  142
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H3 of IGX2415 according to Contact definition

<400>  142

Val Arg His Gln Gln Gln Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr 
1               5                   10                  15      


Gln 
    


<210>  143
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H3 of IGX2415 according to IMGT definition

<400>  143

Val Arg His Gln Gln Gln Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr 
1               5                   10                  15      


Gln His 
        


<210>  144
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region of IGX2711

<400>  144

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Ala Lys Arg Ser Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Met Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Leu Ser Asp Ser Gly Asn Tyr 
                85                  90                  95      


Phe Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  145
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region of IGX2711

<400>  145

Glu Val Gln Leu Val Gln Ser Gly Ala Asp Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Leu Thr Ile Ser Cys Gln Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Lys Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gln Ile Arg Gly Gln His Ser Ser Thr Leu Tyr Gly Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Arg Ser Thr Ala Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Arg Ser Leu Glu Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg His Gly Ala Ser Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr 
            100                 105                 110         


Gln His Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  146
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L2 of IGX2711 according to Chothia, AbM or Kabat 
       definition

<400>  146

Glu Asp Ala Lys Arg Ser Ser 
1               5           


<210>  147
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L2 of IGX2711 according to Contact definition

<400>  147

Leu Val Ile Tyr Glu Asp Ala Lys Arg Ser 
1               5                   10  


<210>  148
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L3 of IGX2711 according to Chothia, AbM, Kabat or
       IMGT definition

<400>  148

Tyr Ser Leu Ser Asp Ser Gly Asn Tyr Phe Val 
1               5                   10      


<210>  149
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L3 of IGX2711 according to Contact definition

<400>  149

Tyr Ser Leu Ser Asp Ser Gly Asn Tyr Phe 
1               5                   10  


<210>  150
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2711 according to Chothia definition

<400>  150

Arg Gly Gln His Ser Ser 
1               5       


<210>  151
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2711 according to AbM definition

<400>  151

Gln Ile Arg Gly Gln His Ser Ser Thr Leu 
1               5                   10  


<210>  152
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2711 according to Kabat definition

<400>  152

Gln Ile Arg Gly Gln His Ser Ser Thr Leu Tyr Gly Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  153
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2711 according to Contact definition

<400>  153

Trp Met Gly Gln Ile Arg Gly Gln His Ser Ser Thr Leu 
1               5                   10              


<210>  154
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2711 according to IMGT definition

<400>  154

Ile Arg Gly Gln His Ser Ser Thr 
1               5               


<210>  155
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H3 of IGX2711 according to Chothia, AbM or Kabat 
       definition

<400>  155

His Gly Ala Ser Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr Gln His 
1               5                   10                  15      


<210>  156
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H3 of IGX2711 according to Contact definition

<400>  156

Val Arg His Gly Ala Ser Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr 
1               5                   10                  15      


Gln 
    


<210>  157
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H3 of IGX2711 according to IMGT definition

<400>  157

Val Arg His Gly Ala Ser Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr 
1               5                   10                  15      


Gln His 
        


<210>  158
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region of IGX2713

<400>  158

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp His Lys Arg Ala Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Met Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Ile Ser Pro Ala Gly Asn Tyr 
                85                  90                  95      


Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  159
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region of IGX2713

<400>  159

Glu Val Gln Leu Val Gln Ser Gly Ala Asp Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Leu Thr Ile Ser Cys Gln Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Lys Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ser Arg His Gly Ser Gln Thr Tyr Tyr Gly Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Arg Ser Thr Ala Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Arg Ser Leu Glu Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Ala Gly Gly Gln Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr 
            100                 105                 110         


Gln His Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  160
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L2 of IGX2713 according to Chothia, AbM or Kabat 
       definition

<400>  160

Glu Asp His Lys Arg Ala Ser 
1               5           


<210>  161
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L2 of IGX2713 according to Contact definition

<400>  161

Leu Val Ile Tyr Glu Asp His Lys Arg Ala 
1               5                   10  


<210>  162
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L3 of IGX2713 according to Chothia, AbM, Kabat or
       IMGT definition

<400>  162

Tyr Ser Ile Ser Pro Ala Gly Asn Tyr Gly Val 
1               5                   10      


<210>  163
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L3 of IGX2713 according to Contact definition

<400>  163

Tyr Ser Ile Ser Pro Ala Gly Asn Tyr Gly 
1               5                   10  


<210>  164
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2713 according to Chothia definition

<400>  164

Ser Arg His Gly Ser Gln 
1               5       


<210>  165
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2713 according to AbM definition

<400>  165

Arg Ile Ser Arg His Gly Ser Gln Thr Tyr 
1               5                   10  


<210>  166
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2713 according to Kabat definition

<400>  166

Arg Ile Ser Arg His Gly Ser Gln Thr Tyr Tyr Gly Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  167
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2713 according to Contact definition

<400>  167

Trp Met Gly Arg Ile Ser Arg His Gly Ser Gln Thr Tyr 
1               5                   10              


<210>  168
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2713 according to IMGT definition

<400>  168

Ile Ser Arg His Gly Ser Gln Thr 
1               5               


<210>  169
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H3 of IGX2713 according to Chothia, AbM or Kabat 
       definition

<400>  169

Ala Gly Gly Gln Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr Gln His 
1               5                   10                  15      


<210>  170
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H3 of IGX2713 according to Contact definition

<400>  170

Val Arg Ala Gly Gly Gln Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr 
1               5                   10                  15      


Gln 
    


<210>  171
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H3 of IGX2713 according to IMGT definition

<400>  171

Val Arg Ala Gly Gly Gln Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr 
1               5                   10                  15      


Gln His 
        


<210>  172
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region of IGX2718

<400>  172

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Thr Lys Arg His Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Met Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Ala Glu His Arg Gly Asn Tyr 
                85                  90                  95      


Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  173
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region of IGX2718

<400>  173

Glu Val Gln Leu Val Gln Ser Gly Ala Asp Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Leu Thr Ile Ser Cys Gln Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Lys Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly His Ile Asn Pro Met Arg Ser Thr Thr Thr Tyr Gly Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Arg Ser Thr Ala Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp His Ser Leu Glu Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asn Asp Asn His Asp Asp Tyr Thr Tyr Thr Asp Asp Trp Gly 
            100                 105                 110         


Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  174
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L2 of IGX2718 according to Chothia, AbM or Kabat 
       definition

<400>  174

Glu Asp Thr Lys Arg His Ser 
1               5           


<210>  175
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L2 of IGX2718 according to Contact definition

<400>  175

Leu Val Ile Tyr Glu Asp Thr Lys Arg His 
1               5                   10  


<210>  176
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L3 of IGX2718 according to Chothia, AbM, Kabat or
       IMGT definition

<400>  176

Tyr Ser Ala Glu His Arg Gly Asn Tyr Ala Val 
1               5                   10      


<210>  177
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-L3 of IGX2718 according to Contact definition

<400>  177

Tyr Ser Ala Glu His Arg Gly Asn Tyr Ala 
1               5                   10  


<210>  178
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2718 according to Chothia definition

<400>  178

Asn Pro Met Arg Ser Thr 
1               5       


<210>  179
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2718 according to AbM definition

<400>  179

His Ile Asn Pro Met Arg Ser Thr Thr Thr 
1               5                   10  


<210>  180
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2718 according to Kabat definition

<400>  180

His Ile Asn Pro Met Arg Ser Thr Thr Thr Tyr Gly Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  181
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2718 according to Contact definition

<400>  181

Trp Met Gly His Ile Asn Pro Met Arg Ser Thr Thr Thr 
1               5                   10              


<210>  182
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H2 of IGX2718 according to IMGT definition

<400>  182

Ile Asn Pro Met Arg Ser Thr Thr 
1               5               


<210>  183
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H3 of IGX2718 according to Chothia, AbM or Kabat 
       definition

<400>  183

Asn Asp Asn His Asp Asp Tyr Thr Tyr Thr Asp Asp 
1               5                   10          


<210>  184
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H3 of IGX2718 according to Contact definition

<400>  184

Val Arg Asn Asp Asn His Asp Asp Tyr Thr Tyr Thr Asp 
1               5                   10              


<210>  185
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of CDR-H3 of IGX2718 according to IMGT definition

<400>  185

Val Arg Asn Asp Asn His Asp Asp Tyr Thr Tyr Thr Asp Asp 
1               5                   10                  


<210>  186
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence of CDR-L2


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is E, W, K, S, N, A, D, H or T

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is A, V, P, G, S, V, L, I or H

<400>  186

Glu Asp Xaa Arg Xaa 
1               5   


<210>  187
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence of CDR-L3


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is Q, L, K, A, T, L or I

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is E, A, N or S

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is R, V, P, Q, A, I, T, D or H

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is N, K, D, Q, E, R, G, S or A

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X is A, F, G, M or R

<400>  187

Tyr Ser Xaa Xaa Xaa Xaa Gly Asn Tyr Xaa Val 
1               5                   10      


<210>  188
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence of CDR-H2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is Q, A, V, E, S, R or H

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is V, N, S, F, T, R or H

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is P, R, K, L, T or G

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is R, H, N, Y, P, S, L, Q or M

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is A, G, P, S, L, Q H or R

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is R, N, T, W, H, S, A or Q

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X is N, M, Y, R, V, H, L or T

<400>  188

Xaa Ile Xaa Xaa Xaa Xaa Ser Xaa Thr Xaa Tyr Gly Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  189
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence of CDR-H3


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is P, S, Q, H or A

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is Y, G, T, W or Q

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is F, G, R, L, Q or A

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is Q, A, L or S

<400>  189

Xaa Xaa Xaa Xaa Thr Ser Gly Gly Thr Ile Pro Glu Tyr Tyr Gln His 
1               5                   10                  15      


<210>  190
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  190

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  191
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  191

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  192
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  192

Asp Trp Val Pro Phe Gln Thr Lys Gly Leu Ala Pro Ala Ser Ala Pro 
1               5                   10                  15      


Gln Asn Leu His Ala Ile Arg Thr Asp Ser Gly Leu Ile Leu 
            20                  25                  30  


<210>  193
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  193

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  194
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal Tag comprising a thrombine cleavage site followed by 
       an octa-histidine (8xHis)-tag coupled to a streptavidin tag

<400>  194

Leu Val Pro Arg Gly Ser Ser Ala His His His His His His His His 
1               5                   10                  15      


Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
            20                  25      


