                         SEQUENCE LISTING

<110>  van Berkel, Patricius HC
       Williams, David G
 
<120>  Humanized Anti - Axl Antibodies

<130>  RKA/7192701

<150>  GB 1506411.6
<151>  2015-04-15

<160>  10    

<170>  PatentIn version 3.3

<210>  1
<211>  146
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic heavy chain variable region 1H12VH

<400>  1

Met Gly Phe Lys Met Glu Ser Gln Phe Gln Val Phe Val Phe Val Phe 
1               5                   10                  15      


Leu Trp Leu Ser Gly Val Asp Gly Glu Val Gln Leu Val Glu Ser Gly 
            20                  25                  30          


Gly Asp Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Thr 
    50                  55                  60                  


Pro Asp Lys Arg Leu Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Ser 
65                  70                  75                  80  


Tyr Thr Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser 
            100                 105                 110         


Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg His Pro Ile Tyr Tyr Thr 
        115                 120                 125             


Tyr Asp Asp Thr Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
    130                 135                 140                 


Ser Ser 
145     


<210>  2
<211>  145
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic heavy chain variable region 1H12RHA

<400>  2

Met Gly Phe Lys Met Glu Ser Gln Phe Gln Val Phe Val Phe Val Phe 
1               5                   10                  15      


Leu Trp Leu Ser Gly Val Asp Gly Gln Val Gln Leu Val Glu Ser Gly 
            20                  25                  30          


Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met Ser Val Arg Gln Ala Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Ser Tyr 
65                  70                  75                  80  


Thr Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                85                  90                  95      


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg His Pro Ile Tyr Tyr Thr Tyr 
        115                 120                 125             


Asp Asp Thr Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
    130                 135                 140                 


Ser 
145 


<210>  3
<211>  146
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic heavy chain variable region 1H12RHB

<400>  3

Met Gly Phe Lys Met Glu Ser Gln Phe Gln Val Phe Val Phe Val Phe 
1               5                   10                  15      


Leu Trp Leu Ser Gly Val Asp Gly Glu Val Gln Leu Val Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Ser 
65                  70                  75                  80  


Tyr Thr Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg His Pro Ile Tyr Tyr Thr 
        115                 120                 125             


Tyr Asp Asp Thr Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser 
145     


<210>  4
<211>  132
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic light chain variable region 1H12VK

<400>  4

Met Gly Phe Lys Met Glu Ser Gln Phe Gln Val Phe Val Phe Val Phe 
1               5                   10                  15      


Leu Trp Leu Ser Gly Val Asp Gly Glu Asn Val Leu Thr Gln Ser Pro 
            20                  25                  30          


Ala Ile Met Ala Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser 
        35                  40                  45              


Ala Ser Ser Ser Val Ser Ser Gly Asn Phe His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Arg Thr Ser Asn Leu Ala 
65                  70                  75                  80  


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
                85                  90                  95      


Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
            100                 105                 110         


Cys Gln Gln Trp Ser Gly Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys 
    130         


<210>  5
<211>  132
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic light chain variable region 1H12RKA

<400>  5

Met Gly Phe Lys Met Glu Ser Gln Phe Gln Val Phe Val Phe Val Phe 
1               5                   10                  15      


Leu Trp Leu Ser Gly Val Asp Gly Glu Ile Val Leu Thr Gln Ser Pro 
            20                  25                  30          


Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser 
        35                  40                  45              


Ala Ser Ser Ser Val Ser Ser Gly Asn Phe His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Leu Ala Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala 
65                  70                  75                  80  


Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
            100                 105                 110         


Cys Gln Gln Trp Ser Gly Tyr Pro Trp Thr Phe Gly Pro Gly Thr Lys 
        115                 120                 125             


Val Asp Ile Lys 
    130         


<210>  6
<211>  132
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic light chain variable region 1H12RKA1

<400>  6

Met Gly Phe Lys Met Glu Ser Gln Phe Gln Val Phe Val Phe Val Phe 
1               5                   10                  15      


Leu Trp Leu Ser Gly Val Asp Gly Glu Asn Val Leu Thr Gln Ser Pro 
            20                  25                  30          


Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser 
        35                  40                  45              


Ala Ser Ser Ser Val Ser Ser Gly Asn Phe His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Leu Ala Pro Arg Leu Trp Ile Tyr Arg Thr Ser Asn Leu Ala 
65                  70                  75                  80  


Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
                85                  90                  95      


Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
            100                 105                 110         


Cys Gln Gln Trp Ser Gly Tyr Pro Trp Thr Phe Gly Pro Gly Thr Lys 
        115                 120                 125             


Val Asp Ile Lys 
    130         


<210>  7
<211>  132
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic light chain variable region 1H12RKB

<400>  7

Met Gly Phe Lys Met Glu Ser Gln Phe Gln Val Phe Val Phe Val Phe 
1               5                   10                  15      


Leu Trp Leu Ser Gly Val Asp Gly Glu Ile Val Leu Thr Gln Ser Pro 
            20                  25                  30          


Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser 
        35                  40                  45              


Ala Ser Ser Ser Val Ser Ser Gly Asn Phe His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Leu Ala Pro Arg Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala 
65                  70                  75                  80  


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
            100                 105                 110         


Cys Gln Gln Trp Ser Gly Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys 
    130         


<210>  8
<211>  132
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic light chain variable region 1H12RKB1

<400>  8

Met Gly Phe Lys Met Glu Ser Gln Phe Gln Val Phe Val Phe Val Phe 
1               5                   10                  15      


Leu Trp Leu Ser Gly Val Asp Gly Glu Asn Val Leu Thr Gln Ser Pro 
            20                  25                  30          


Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser 
        35                  40                  45              


Ala Ser Ser Ser Val Ser Ser Gly Asn Phe His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Leu Ala Pro Arg Leu Trp Ile Tyr Arg Thr Ser Asn Leu Ala 
65                  70                  75                  80  


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
            100                 105                 110         


Cys Gln Gln Trp Ser Gly Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys 
    130         


<210>  9
<211>  894
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln 
            420                 425                 430         


Pro Val His Gln Leu Val Lys Glu Pro Ser Thr Pro Ala Phe Ser Trp 
        435                 440                 445             


Pro Trp Trp Tyr Val Leu Leu Gly Ala Val Val Ala Ala Ala Cys Val 
    450                 455                 460                 


Leu Ile Leu Ala Leu Phe Leu Val His Arg Arg Lys Lys Glu Thr Arg 
465                 470                 475                 480 


Tyr Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val Val 
                485                 490                 495     


Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr 
            500                 505                 510         


Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp 
        515                 520                 525             


Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly Glu 
    530                 535                 540                 


Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp Ser 
545                 550                 555                 560 


Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr Arg 
                565                 570                 575     


Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu Phe 
            580                 585                 590         


Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly Ser 
        595                 600                 605             


Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met Lys 
    610                 615                 620                 


His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln 
625                 630                 635                 640 


Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp Ile 
                645                 650                 655     


Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg Asp 
            660                 665                 670         


Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys Val 
        675                 680                 685             


Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg 
    690                 695                 700                 


Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser 
705                 710                 715                 720 


Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe Gly 
                725                 730                 735     


Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly 
            740                 745                 750         


Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Arg Gly Asn Arg Leu 
        755                 760                 765             


Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg 
    770                 775                 780                 


Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe Thr Glu Leu Arg 
785                 790                 795                 800 


Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro 
                805                 810                 815     


Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Gly Tyr Pro Glu 
            820                 825                 830         


Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln Pro Asp Pro 
        835                 840                 845             


Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val His Pro Ala Gly 
    850                 855                 860                 


Arg Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro Ala Gln Pro Ala 
865                 870                 875                 880 


Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp Gly Ala 
                885                 890                 


<210>  10
<211>  888
<212>  PRT
<213>  Mus musculus

<400>  10

Met Gly Arg Val Pro Leu Ala Trp Trp Leu Ala Leu Cys Cys Trp Gly 
1               5                   10                  15      


Cys Ala Ala His Lys Asp Thr Gln Thr Glu Ala Gly Ser Pro Phe Val 
            20                  25                  30          


Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg Gly Leu Thr Gly Thr Leu 
        35                  40                  45              


Arg Cys Glu Leu Gln Val Gln Gly Glu Pro Pro Glu Val Val Trp Leu 
    50                  55                  60                  


Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp Asn Thr Gln Thr Gln Val 
65                  70                  75                  80  


Pro Leu Gly Glu Asp Trp Gln Asp Glu Trp Lys Val Val Ser Gln Leu 
                85                  90                  95      


Arg Ile Ser Ala Leu Gln Leu Ser Asp Ala Gly Glu Tyr Gln Cys Met 
            100                 105                 110         


Val His Leu Glu Gly Arg Thr Phe Val Ser Gln Pro Gly Phe Val Gly 
        115                 120                 125             


Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu Pro Glu Asp Lys Ala Val 
    130                 135                 140                 


Pro Ala Asn Thr Pro Phe Asn Leu Ser Cys Gln Ala Gln Gly Pro Pro 
145                 150                 155                 160 


Glu Pro Val Thr Leu Leu Trp Leu Gln Asp Ala Val Pro Leu Ala Pro 
                165                 170                 175     


Val Thr Gly His Ser Ser Gln His Ser Leu Gln Thr Pro Gly Leu Asn 
            180                 185                 190         


Lys Thr Ser Ser Phe Ser Cys Glu Ala His Asn Ala Lys Gly Val Thr 
        195                 200                 205             


Thr Ser Arg Thr Ala Thr Ile Thr Val Leu Pro Gln Arg Pro His His 
    210                 215                 220                 


Leu His Val Val Ser Arg Gln Pro Thr Glu Leu Glu Val Ala Trp Thr 
225                 230                 235                 240 


Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr His Cys Asn Leu Gln Ala 
                245                 250                 255     


Val Leu Ser Asp Asp Gly Val Gly Ile Trp Leu Gly Lys Ser Asp Pro 
            260                 265                 270         


Pro Glu Asp Pro Leu Thr Leu Gln Val Ser Val Pro Pro His Gln Leu 
        275                 280                 285             


Arg Leu Glu Lys Leu Leu Pro His Thr Pro Tyr His Ile Arg Ile Ser 
    290                 295                 300                 


Cys Ser Ser Ser Gln Gly Pro Ser Pro Trp Thr His Trp Leu Pro Val 
305                 310                 315                 320 


Glu Thr Thr Glu Gly Val Pro Leu Gly Pro Pro Glu Asn Val Ser Ala 
                325                 330                 335     


Met Arg Asn Gly Ser Gln Val Leu Val Arg Trp Gln Glu Pro Arg Val 
            340                 345                 350         


Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg Leu Ala Tyr Arg Gly Gln 
        355                 360                 365             


Asp Thr Pro Glu Val Leu Met Asp Ile Gly Leu Thr Arg Glu Val Thr 
    370                 375                 380                 


Leu Glu Leu Arg Gly Asp Arg Pro Val Ala Asn Leu Thr Val Ser Val 
385                 390                 395                 400 


Thr Ala Tyr Thr Ser Ala Gly Asp Gly Pro Trp Ser Leu Pro Val Pro 
                405                 410                 415     


Leu Glu Pro Trp Arg Pro Gly Gln Gly Gln Pro Leu His His Leu Val 
            420                 425                 430         


Ser Glu Pro Pro Pro Arg Ala Phe Ser Trp Pro Trp Trp Tyr Val Leu 
        435                 440                 445             


Leu Gly Ala Leu Val Ala Ala Ala Cys Val Leu Ile Leu Ala Leu Phe 
    450                 455                 460                 


Leu Val His Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu 
465                 470                 475                 480 


Pro Thr Val Glu Arg Gly Glu Leu Val Val Arg Tyr Arg Val Arg Lys 
                485                 490                 495     


Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile 
            500                 505                 510         


Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp Val Met Val Asp Arg His 
        515                 520                 525             


Lys Val Ala Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Ala Val 
    530                 535                 540                 


Met Glu Gly Gln Leu Asn Gln Asp Asp Ser Ile Leu Lys Val Ala Val 
545                 550                 555                 560 


Lys Thr Met Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe 
                565                 570                 575     


Leu Ser Glu Ala Val Cys Met Lys Glu Phe Asp His Pro Asn Val Met 
            580                 585                 590         


Arg Leu Ile Gly Val Cys Phe Gln Gly Ser Asp Arg Glu Gly Phe Pro 
        595                 600                 605             


Glu Pro Val Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His Ser 
    610                 615                 620                 


Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln Pro Val Phe Leu Pro Thr 
625                 630                 635                 640 


Gln Met Leu Val Lys Phe Met Ala Asp Ile Ala Ser Gly Met Glu Tyr 
                645                 650                 655     


Leu Ser Thr Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys 
            660                 665                 670         


Met Leu Asn Glu Asn Met Ser Val Cys Val Ala Asp Phe Gly Leu Ser 
        675                 680                 685             


Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys 
    690                 695                 700                 


Met Pro Val Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr 
705                 710                 715                 720 


Thr Ser Lys Ser Asp Val Trp Ser Phe Gly Val Thr Met Trp Glu Ile 
                725                 730                 735     


Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile 
            740                 745                 750         


Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu Lys Gln Pro Val Asp Cys 
        755                 760                 765             


Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu Leu Asn Pro 
    770                 775                 780                 


Arg Asp Arg Pro Ser Phe Ala Glu Leu Arg Glu Asp Leu Glu Asn Thr 
785                 790                 795                 800 


Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val 
                805                 810                 815     


Asn Met Asp Glu Gly Gly Ser His Leu Glu Pro Arg Gly Ala Ala Gly 
            820                 825                 830         


Gly Ala Asp Pro Pro Thr Gln Pro Asp Pro Lys Asp Ser Cys Ser Cys 
        835                 840                 845             


Leu Thr Ala Ala Asp Val His Ser Ala Gly Arg Tyr Val Leu Cys Pro 
    850                 855                 860                 


Ser Thr Ala Pro Gly Pro Thr Leu Ser Ala Asp Arg Gly Cys Pro Ala 
865                 870                 875                 880 


Pro Pro Gly Gln Glu Asp Gly Ala 
                885             


