
SEQUENCE LISTING


<110> CELLECTIS

<120> Engineering animal or plant genome using DNA-guided Argonaute 
      interference systems (DAIS) from mesophilic prokaryotes

<130> P81501592PCT00

<150> PA201570230
<151> 2015-04-17

<160> 37

<170> PatentIn version 3.5


<210>  1

<211>  685
<212>  PRT
<213>  Thermus thermophilus
<220>

<400>  1

Met Asn His Leu Gly Lys Thr Glu Val Phe Leu Asn Arg Phe Ala Leu 
1               5                   10                  15      


Arg Pro Leu Asn Pro Glu Glu Leu Arg Pro Trp Arg Leu Glu Val Val 
            20                  25                  30          


Leu Asp Pro Pro Pro Gly Arg Glu Glu Val Tyr Pro Leu Leu Ala Gln 
        35                  40                  45              


Val Ala Arg Arg Ala Gly Gly Val Thr Val Arg Met Gly Asp Gly Leu 
    50                  55                  60                  


Ala Ser Trp Ser Pro Pro Glu Val Leu Val Leu Glu Gly Thr Leu Ala 
65                  70                  75                  80  


Arg Met Gly Gln Thr Tyr Ala Tyr Arg Leu Tyr Pro Lys Gly Arg Arg 
                85                  90                  95      


Pro Leu Asp Pro Lys Asp Pro Gly Glu Arg Ser Val Leu Ser Ala Leu 
            100                 105                 110         


Ala Arg Arg Leu Leu Gln Glu Arg Leu Arg Arg Leu Glu Gly Val Trp 
        115                 120                 125             


Val Glu Gly Leu Ala Val Tyr Arg Arg Glu His Ala Arg Gly Pro Gly 
    130                 135                 140                 


Trp Arg Val Leu Gly Gly Ala Val Leu Asp Leu Trp Val Ser Asp Ser 
145                 150                 155                 160 


Gly Ala Phe Leu Leu Glu Val Asp Pro Ala Tyr Arg Ile Leu Cys Glu 
                165                 170                 175     


Met Ser Leu Glu Ala Trp Leu Ala Gln Gly His Pro Leu Pro Lys Arg 
            180                 185                 190         


Val Arg Asn Ala Tyr Asp Arg Arg Thr Trp Glu Leu Leu Arg Leu Gly 
        195                 200                 205             


Glu Glu Asp Pro Lys Glu Leu Pro Leu Pro Gly Gly Leu Ser Leu Leu 
    210                 215                 220                 


Asp Tyr His Ala Ser Lys Gly Arg Leu Gln Gly Arg Glu Gly Gly Arg 
225                 230                 235                 240 


Val Ala Trp Val Ala Asp Pro Lys Asp Pro Arg Lys Pro Ile Pro His 
                245                 250                 255     


Leu Thr Gly Leu Leu Val Pro Val Leu Thr Leu Glu Asp Leu His Glu 
            260                 265                 270         


Glu Glu Gly Ser Leu Ala Leu Ser Leu Pro Trp Glu Glu Arg Arg Arg 
        275                 280                 285             


Arg Thr Arg Glu Ile Ala Ser Trp Ile Gly Arg Arg Leu Gly Leu Gly 
    290                 295                 300                 


Thr Pro Glu Ala Val Arg Ala Gln Ala Tyr Arg Leu Ser Ile Pro Lys 
305                 310                 315                 320 


Leu Met Gly Arg Arg Ala Val Ser Lys Pro Ala Asp Ala Leu Arg Val 
                325                 330                 335     


Gly Phe Tyr Arg Ala Gln Glu Thr Ala Leu Ala Leu Leu Arg Leu Asp 
            340                 345                 350         


Gly Ala Gln Gly Trp Pro Glu Phe Leu Arg Arg Ala Leu Leu Arg Ala 
        355                 360                 365             


Phe Gly Ala Ser Gly Ala Ser Leu Arg Leu His Thr Leu His Ala His 
    370                 375                 380                 


Pro Ser Gln Gly Leu Ala Phe Arg Glu Ala Leu Arg Lys Ala Lys Glu 
385                 390                 395                 400 


Glu Gly Val Gln Ala Val Leu Val Leu Thr Pro Pro Met Ala Trp Glu 
                405                 410                 415     


Asp Arg Asn Arg Leu Lys Ala Leu Leu Leu Arg Glu Gly Leu Pro Ser 
            420                 425                 430         


Gln Ile Leu Asn Val Pro Leu Arg Glu Glu Glu Arg His Arg Trp Glu 
        435                 440                 445             


Asn Ala Leu Leu Gly Leu Leu Ala Lys Ala Gly Leu Gln Val Val Ala 
    450                 455                 460                 


Leu Ser Gly Ala Tyr Pro Ala Glu Leu Ala Val Gly Phe Asp Ala Gly 
465                 470                 475                 480 


Gly Arg Glu Ser Phe Arg Phe Gly Gly Ala Ala Cys Ala Val Gly Gly 
                485                 490                 495     


Asp Gly Gly His Leu Leu Trp Thr Leu Pro Glu Ala Gln Ala Gly Glu 
            500                 505                 510         


Arg Ile Pro Gln Glu Val Val Trp Asp Leu Leu Glu Glu Thr Leu Trp 
        515                 520                 525             


Ala Phe Arg Arg Lys Ala Gly Arg Leu Pro Ser Arg Val Leu Leu Leu 
    530                 535                 540                 


Arg Asp Gly Arg Val Pro Gln Asp Glu Phe Ala Leu Ala Leu Glu Ala 
545                 550                 555                 560 


Leu Ala Arg Glu Gly Ile Ala Tyr Asp Leu Val Ser Val Arg Lys Ser 
                565                 570                 575     


Gly Gly Gly Arg Val Tyr Pro Val Gln Gly Arg Leu Ala Asp Gly Leu 
            580                 585                 590         


Tyr Val Pro Leu Glu Asp Lys Thr Phe Leu Leu Leu Thr Val His Arg 
        595                 600                 605             


Asp Phe Arg Gly Thr Pro Arg Pro Leu Lys Leu Val His Glu Ala Gly 
    610                 615                 620                 


Asp Thr Pro Leu Glu Ala Leu Ala His Gln Ile Phe His Leu Thr Arg 
625                 630                 635                 640 


Leu Tyr Pro Ala Ser Gly Phe Ala Phe Pro Arg Leu Pro Ala Pro Leu 
                645                 650                 655     


His Leu Ala Asp Arg Leu Val Lys Glu Val Gly Arg Leu Gly Ile Arg 
            660                 665                 670         


His Leu Lys Glu Val Asp Arg Glu Lys Leu Phe Phe Val 
        675                 680                 685 



<210>  2

<211>  615
<212>  PRT
<213>  Synechococcus sp. PCC 7002

<220>
<223>  Ago protein

<400>  2
Met Ile Cys Trp Gln Lys Thr Glu Ala Asp Ile Arg Ser Asp Val Ser 
1               5                   10                  15      


Gly Trp Glu Ile Tyr Arg Gly Phe Lys Leu Asp Ile Phe Val Ser Ser 
            20                  25                  30          


Gln Gly Asn Val Phe Leu Glu Val Asp Glu His Tyr Lys Leu Phe Ser 
        35                  40                  45              


Ala Trp Thr Leu Thr Gln Trp Leu Glu Trp Tyr Pro Asp Phe Ser Ala 
    50                  55                  60                  


Lys Ile Leu Arg Asn Thr Tyr Asp Gly Arg Thr Trp Lys Leu Gln Lys 
65                  70                  75                  80  


Ile Thr Asn Glu Asp Pro Asn Asn Ile Asp Ser Gly Thr Gly Gln Thr 
                85                  90                  95      


Leu Ala Thr Tyr His Lys Asn His Gln Lys Pro Ala Thr Asp Gln Glu 
            100                 105                 110         


Ile Asn Ser Ser Lys Val Ile Tyr Val Lys Pro Tyr Asn Ser Lys Lys 
        115                 120                 125             


Glu Glu Ser Tyr Pro His Leu Ser Ser Arg Val Lys Pro Cys Leu Phe 
    130                 135                 140                 


Leu Asp Thr Leu Ser Glu Leu Ala Ser Gln Gly Asp Arg Lys Val Lys 
145                 150                 155                 160 


Glu Val Phe Asn Leu Ile Lys Pro Ser Ile Glu Asp Arg Phe Ser Arg 
                165                 170                 175     


Ala Thr Glu Ile Ala Lys Gln Leu Ala Val Glu Ile Tyr Asn Ile Asp 
            180                 185                 190         


Glu Glu Ile Ser Asp Asp Ile Lys Val Val Gln Val Gln Ala Gln Gln 
        195                 200                 205             


Ser Ser Gln Asp Lys Ser Ile Leu Leu Ala His Ser Ser Lys Arg Ile 
    210                 215                 220                 


Asp Lys Val Phe Lys Ser Leu Asp Gln Gly Cys Phe Arg Val Gly Glu 
225                 230                 235                 240 


Ile Lys Phe Gly Cys Ile Asn Leu Leu Asp Lys Asn Gln Asp Gly Trp 
                245                 250                 255     


Ser Lys Phe Ile Leu Gln Lys Leu Gln Lys Leu Ala Thr Ile His Asn 
            260                 265                 270         


Ile Asn Ile Asp Ala Asn Leu Val Lys Ala Ala Val Asp Ile Pro Glu 
        275                 280                 285             


Lys Asp Phe Glu Ile Asp Gln Phe Trp Glu Ser Trp Val Glu Gln Asp 
    290                 295                 300                 


Ile Lys Thr Ile Leu Val Ile Ser Glu Trp Leu Asp Asn Lys Tyr Lys 
305                 310                 315                 320 


Thr Lys Leu Thr Arg Asp Ala Leu Glu His Gly Ile Thr Leu Gln Phe 
                325                 330                 335     


Met Leu Pro Leu Lys Glu Asn Val Arg Arg Ile Glu Ser Asn Lys Gly 
            340                 345                 350         


Val Glu Ser Lys Ile Thr Cys Phe Thr Ser Asp Gln Tyr Arg Ala Asn 
        355                 360                 365             


Asn Ile Leu Leu Gly Leu Leu Ala Lys Ala Gly Trp Gln Ala Val Gly 
    370                 375                 380                 


Leu Pro Leu Leu Asn Asn Glu Tyr Ala Ala Asp Leu Val Ile Gly Phe 
385                 390                 395                 400 


Asp Ala Gly Arg Asn Glu Thr Leu Ser Tyr Gly Thr Ser Ser Phe Ala 
                405                 410                 415     


Val Leu Ala Asp Gly Gln Ile Leu Gly Trp Glu Leu Pro Glu Ala Gln 
            420                 425                 430         


Lys Gly Glu Ile Leu Asp Pro Asp His Val Arg Arg Thr Val Arg Arg 
        435                 440                 445             


Ile Ile Ser Gln Phe Gln Lys Met Asn Gly Lys Gln Ser Pro Lys Arg 
    450                 455                 460                 


Ile Leu Leu Met Arg Asp Gly Leu Ile Gln Gln Gln Glu Phe Ser Leu 
465                 470                 475                 480 


Ile Thr Glu Ala Leu Glu Glu Gly Glu Ile Lys Tyr Asp Leu Ile Ser 
                485                 490                 495     


Val Arg Lys Ser Gly Ala Gly Arg Ile Gly Arg Arg Asn Ser Asp Gly 
            500                 505                 510         


Thr Tyr Val Asp Ala Pro Lys Gly Thr Val Ile Phe Ser Gly Asn Asp 
        515                 520                 525             


Lys Phe Lys Ile Val Thr Ser Glu Ala Lys Ala Gly Gly Ser Ala Arg 
    530                 535                 540                 


Pro Leu Phe Val Val Arg Glu Gln Gly Asp Thr Pro Ile Glu Ile Ile 
545                 550                 555                 560 


Ala Glu Gln Phe Tyr Arg Leu Thr Gln Leu His Pro Val Ser Gly Ser 
                565                 570                 575     


Phe Thr Ser Arg Leu Pro Met Pro Leu Asn Tyr Ala Asp Lys Leu Ala 
            580                 585                 590         


Lys Lys Ile Gln Ser Leu Gly Ser Val Gly Ile Leu Gln Asn Leu Asp 
        595                 600                 605             


Arg Lys Lys Leu Phe Phe Val 
    610                 615 


<210>  3

<211>  735
<212>  PRT
<213>  Synechococcus elongatus

<220>
<223>  Ago protein

<400>  3
Met Asp Leu Leu Ser Asn Leu Arg Arg Ser Ser Ile Val Leu Asn Arg 
1               5                   10                  15      


Phe Tyr Val Lys Ser Leu Ser Gln Ser Asp Leu Thr Ala Tyr Glu Tyr 
            20                  25                  30          


Arg Cys Ile Phe Lys Lys Thr Pro Glu Leu Gly Asp Glu Lys Arg Leu 
        35                  40                  45              


Leu Ala Ser Ile Cys Tyr Lys Leu Gly Ala Ile Ala Val Arg Ile Gly 
    50                  55                  60                  


Ser Asn Ile Ile Thr Lys Glu Ala Val Arg Pro Glu Lys Leu Gln Gly 
65                  70                  75                  80  


His Asp Trp Gln Leu Val Gln Met Gly Thr Lys Gln Leu Asp Cys Arg 
                85                  90                  95      


Asn Asp Ala His Arg Cys Ala Leu Glu Thr Phe Glu Arg Lys Phe Leu 
            100                 105                 110         


Glu Arg Asp Leu Ser Ala Ser Ser Gln Thr Glu Val Arg Lys Ala Ala 
        115                 120                 125             


Glu Gly Gly Leu Ile Trp Trp Val Val Gly Ala Lys Gly Ile Glu Lys 
    130                 135                 140                 


Ser Gly Asn Gly Trp Glu Val His Arg Gly Arg Arg Ile Asp Val Ser 
145                 150                 155                 160 


Leu Asp Ala Glu Gly Asn Leu Tyr Leu Glu Ile Asp Ile His His Arg 
                165                 170                 175     


Phe Tyr Thr Pro Trp Thr Val His Gln Trp Leu Glu Gln Tyr Pro Glu 
            180                 185                 190         


Ile Pro Leu Ser Tyr Val Arg Asn Asn Tyr Leu Asp Glu Arg His Gly 
        195                 200                 205             


Phe Ile Asn Trp Gln Tyr Gly Arg Phe Thr Gln Glu Arg Pro Gln Asp 
    210                 215                 220                 


Ile Leu Leu Asp Cys Leu Gly Met Ser Leu Ala Glu Tyr His Leu Asn 
225                 230                 235                 240 


Lys Gly Ala Thr Glu Glu Glu Val Gln Gln Ser Tyr Val Val Tyr Val 
                245                 250                 255     


Lys Pro Ile Ser Trp Arg Lys Gly Lys Leu Thr Ala His Leu Ser Arg 
            260                 265                 270         


Arg Leu Ser Pro Ser Leu Thr Met Glu Met Leu Ala Lys Val Ala Glu 
        275                 280                 285             


Asp Ser Thr Val Cys Asp Arg Glu Lys Arg Glu Ile Arg Ala Val Phe 
    290                 295                 300                 


Lys Ser Ile Lys Gln Ser Ile Asn Gln Arg Leu Gln Glu Ala Gln Lys 
305                 310                 315                 320 


Thr Ala Ser Trp Ile Leu Thr Lys Thr Tyr Gly Ile Ser Ser Pro Ala 
                325                 330                 335     


Ile Ala Leu Ser Cys Asp Gly Tyr Leu Leu Pro Ala Ala Lys Leu Leu 
            340                 345                 350         


Ala Ala Asn Lys Gln Pro Val Ser Lys Thr Ala Asp Ile Arg Asn Lys 
        355                 360                 365             


Gly Cys Ala Lys Ile Gly Glu Thr Ser Phe Gly Tyr Leu Asn Leu Tyr 
    370                 375                 380                 


Asn Asn Gln Leu Gln Tyr Pro Leu Glu Val His Lys Cys Leu Leu Glu 
385                 390                 395                 400 


Ile Ala Asn Lys Asn Asn Leu Gln Leu Ser Leu Asp Gln Arg Arg Val 
                405                 410                 415     


Leu Ser Asp Tyr Pro Gln Asp Asp Leu Asp Gln Gln Met Phe Trp Gln 
            420                 425                 430         


Thr Trp Ser Ser Gln Gly Ile Lys Thr Val Leu Val Val Met Pro Trp 
        435                 440                 445             


Asp Ser His His Asp Lys Gln Lys Ile Arg Ile Gln Ala Ile Gln Ala 
    450                 455                 460                 


Gly Ile Ala Thr Gln Phe Met Val Pro Leu Pro Lys Ala Asp Lys Tyr 
465                 470                 475                 480 


Lys Ala Leu Asn Val Thr Leu Gly Leu Leu Cys Lys Ala Gly Trp Gln 
                485                 490                 495     


Pro Ile Gln Leu Glu Ser Val Asp His Pro Glu Val Ala Asp Leu Ile 
            500                 505                 510         


Ile Gly Phe Asp Thr Gly Thr Asn Arg Glu Leu Tyr Tyr Gly Thr Ser 
        515                 520                 525             


Ala Phe Ala Val Leu Ala Asp Gly Gln Ser Leu Gly Trp Glu Leu Pro 
    530                 535                 540                 


Ala Val Gln Gly Gly Glu Thr Phe Ser Gly Gln Ala Ile Trp Gln Thr 
545                 550                 555                 560 


Val Ser Lys Leu Ile Ile Lys Phe Tyr Gln Ile Cys Gln Arg Tyr Pro 
                565                 570                 575     


Gln Lys Leu Leu Leu Met Arg Asp Gly Leu Val Gln Glu Gly Glu Phe 
            580                 585                 590         


Gln Gln Thr Ile Glu Leu Leu Lys Glu Arg Lys Ile Ala Val Asp Val 
        595                 600                 605             


Ile Ser Val Arg Lys Ser Gly Ala Gly Arg Met Gly Gln Glu Ile Tyr 
    610                 615                 620                 


Glu Asn Gly Gln Leu Val Tyr Arg Asp Ala Ala Ile Gly Ser Val Ile 
625                 630                 635                 640 


Leu Gln Pro Ala Glu Arg Ser Phe Ile Met Val Thr Ser Gln Pro Val 
                645                 650                 655     


Ser Lys Thr Ile Gly Ser Ile Arg Pro Leu Arg Ile Val His Glu Tyr 
            660                 665                 670         


Gly Ser Thr Asp Leu Glu Leu Leu Ala Leu Gln Thr Tyr His Leu Thr 
        675                 680                 685             


Gln Leu His Pro Ala Ser Gly Phe Arg Ser Cys Arg Leu Pro Trp Val 
    690                 695                 700                 


Leu His Leu Ala Asp Arg Ser Ser Lys Glu Phe Gln Arg Ile Gly Gln 
705                 710                 715                 720 


Ile Ser Val Leu Gln Asn Ile Ser Arg Asp Lys Leu Ile Ala Val 
                725                 730                 735 


<210>  4

<211>  731
<212>  PRT
<213>  Synechocystis sp

<220>
<223>  Ago protein

<400>  4
Met Asn Leu Leu Ala Arg Ile Glu Lys Thr Ser Val Val Leu Asn His 
1               5                   10                  15      


Phe Phe Val Lys Asn Leu Asp Lys Glu Asp Leu Cys Phe His Glu Tyr 
            20                  25                  30          


Gln Cys Lys Phe Ser Gln Pro Pro Gln Gln Gly Asp Glu Gln Arg Ala 
        35                  40                  45              


Ile Ser Ser Ile Cys Tyr Lys Val Gly Val Thr Ala Val Arg Leu Gly 
    50                  55                  60                  


Ser Arg Ile Ile Thr Lys Glu Glu Val Ser Cys Glu Lys Met Lys Gly 
65                  70                  75                  80  


Ser Ser Trp Lys Leu Val Lys Met Ser Asp Arg Glu Leu Ser Cys Glu 
                85                  90                  95      


Asp Asn Leu Gln Arg Lys Ala Ile Glu Ile Phe Glu Arg Lys Ile Leu 
            100                 105                 110         


Glu Lys Gln Leu Lys Tyr Phe Asn Lys Thr Ala Ile Glu Lys Ala Thr 
        115                 120                 125             


Glu Gly Gly Leu Ile Trp Trp Ile Arg Asp Gln His Gly Val Glu Lys 
    130                 135                 140                 


Phe Gly Asn Gly Trp Glu Val His Arg Gly Arg Lys Ile Asp Val Val 
145                 150                 155                 160 


Ile Asp Ser Asp Lys Asn Leu Tyr Leu Glu Ile Asp Ile His His Arg 
                165                 170                 175     


Phe Tyr Thr Pro Trp Thr Leu His Gln Trp Leu Glu Asn Tyr Pro Asp 
            180                 185                 190         


Ile Pro Ile Asn Tyr Val Arg Asn Thr Tyr Lys Asp Gln Asn Asn Asn 
        195                 200                 205             


Tyr Ile Ser Trp Gln Tyr Glu Glu Val Ser Glu Gln Ser Pro Gln Glu 
    210                 215                 220                 


Thr Ile Val Glu Gly Leu Gly Ile Ser Leu Ala Asp Tyr His Arg Asn 
225                 230                 235                 240 


Asn Gly Ala Ser Glu Glu Glu Ile Ser Ser Ile Val Val Tyr Val Arg 
                245                 250                 255     


Arg Ala Asp Arg Trp Asn Ser Lys Ser Val Ala His Leu Ser Lys Arg 
            260                 265                 270         


Leu Ser Pro Ser Leu Thr Met Glu Met Leu Ala Asn Ile Ser Glu Gln 
        275                 280                 285             


Gly Lys Asp Ser Lys Glu Ile Lys Asp Val Phe Gly Leu Ile Arg Lys 
    290                 295                 300                 


Lys Leu Asp Asp Arg Leu Lys Glu Ser Lys Ala Thr Ala Lys Tyr Ile 
305                 310                 315                 320 


Ile Ser Gln Val Tyr Gly Ile Pro Arg Glu Thr Glu Pro Leu Arg Val 
                325                 330                 335     


Asp Gly Tyr Val Met Pro Lys Ala Lys Leu Leu Ala Leu Asn Gly Gln 
            340                 345                 350         


Glu Val Asp Ile Val Ala Lys Val Arg Tyr Lys Gly Cys Ala Lys Ile 
        355                 360                 365             


Gly Glu Thr Lys Phe Gly Cys Leu Asn Leu Phe Asn Glu Lys His Gln 
    370                 375                 380                 


Tyr Pro Glu Glu Val Ser Lys Cys Leu Leu Asp Ile Glu Lys Asn Ser 
385                 390                 395                 400 


His Thr Lys Ile Lys Ile Asn Ser Tyr Arg Ala Gln Gln Asp Phe Pro 
                405                 410                 415     


Asp Ser Glu Leu Glu Gln Gln Met Phe Trp Gln Lys Trp Ser Asp Glu 
            420                 425                 430         


Gly Ile Lys Thr Val Leu Val Val Met Asp Trp Ser Pro Asn Glu Arg 
        435                 440                 445             


Lys Gln Lys Ile Arg Val Gln Ala Leu Gln Ala Gly Ile Ala Thr Gln 
    450                 455                 460                 


Phe Ile Val Pro Lys Pro Lys Ala Asp Pro Tyr Lys Ala Leu Asn Val 
465                 470                 475                 480 


Val Leu Gly Leu Leu Cys Lys Ala Gly Trp Gln Pro Val Arg Leu Ala 
                485                 490                 495     


Pro Leu Gln Tyr Asp Glu Thr Ala Asp Leu Ile Ile Gly Phe Asp Thr 
            500                 505                 510         


Gly Thr Asn Arg Glu Leu Tyr Tyr Gly Thr Ser Ala Phe Ala Val Leu 
        515                 520                 525             


Ala Asp Gly Gln Ser Leu Gly Trp Glu Leu Pro Asp Ile Gln Arg Gly 
    530                 535                 540                 


Glu Ser Phe Ser Gly Lys Ala Ile Trp Gln Thr Val Ser Lys Leu Val 
545                 550                 555                 560 


Leu Lys Phe His Gln Ser Cys Lys Arg Tyr Pro Lys Lys Leu Leu Leu 
                565                 570                 575     


Met Arg Asp Gly Leu Val Gln Glu Gly Glu Phe Gln Gln Thr Ile Glu 
            580                 585                 590         


Glu Leu Val Lys Ser Asn Ile Ala Val Asp Val Val Gly Val Arg Lys 
        595                 600                 605             


Ser Gly Thr Ala Arg Met Gly Gln Glu Ile Ile Gln Asp Asn Gly Glu 
    610                 615                 620                 


Val Ala Tyr Arg Asp Ala Arg Val Gly Thr Val Ile Phe Ala Arg Lys 
625                 630                 635                 640 


Glu Arg Ser Phe Thr Ile Val Thr Ser Gln Pro Val Thr Ala Gln Ile 
                645                 650                 655     


Gly Ser Ala Lys Pro Leu Arg Val Val His Glu Tyr Gly Asn Thr Ser 
            660                 665                 670         


Leu Asp Leu Leu Ala Leu Gln Thr Tyr Gln Leu Thr Gln Leu His Pro 
        675                 680                 685             


Ala Ser Gly Phe Arg Ser Cys Arg Leu Pro Trp Val Leu His Leu Ala 
    690                 695                 700                 


Asp Arg Ser Ser Lys Glu Phe Gln Arg Leu Gly Gln Ile Ser Ile Leu 
705                 710                 715                 720 


Gln Asn Ile Ser Arg Glu Lys Leu Ile Ala Val 
                725                 730     


<210>  5

<211>  727
<212>  PRT
<213>  Aromatoleum aromaticum EbN1

<220>
<223>  Ago protein

<400>  5
Met Pro Val Tyr Tyr Tyr Arg Leu Thr Phe Asp Asp Asp His Glu Asp 
1               5                   10                  15      


Ile Asn Pro Thr Gln Leu Thr Arg Arg Gly Ala Arg Met Leu Ser Gly 
            20                  25                  30          


Ala Asn Gly Trp Cys Ala Val Thr Asp Gly Glu Pro Leu Arg Val Leu 
        35                  40                  45              


Ser Leu Arg Pro Leu Lys Val Leu Arg His Glu Trp Asn Gly Met Cys 
    50                  55                  60                  


Cys Thr Ala Ser Asp Glu Thr Ala Gly Thr Leu Lys Ser Ala Asn Pro 
65                  70                  75                  80  


Ser Glu Arg Glu Ala Ile Gln Arg Leu Leu Asn Gln Cys Leu Met Gln 
                85                  90                  95      


Gly Ala Arg Lys Leu Ala Tyr Ser Ser Asp Gly Gly Leu Glu Ala Glu 
            100                 105                 110         


Gln Gly Ala Gly Asn Leu Val Arg Leu Thr Ala Cys Gln Pro Ser Glu 
        115                 120                 125             


Arg Val Ser Ala Gly Gly Asp Tyr Leu Asp Ala Phe Gln Ser Val Thr 
    130                 135                 140                 


Leu Ile Pro Asp Val Leu Pro Asp Gly Thr Ala Leu Val Gly Phe Asp 
145                 150                 155                 160 


Val Arg His Arg Leu Leu Pro Arg Pro His Leu Thr Leu Asp Trp Val 
                165                 170                 175     


Ile Arg Lys Arg Pro Glu Trp Met Glu Gly Ile Arg Arg Val Arg His 
            180                 185                 190         


Arg Tyr Val Ser Asn Gly Gln Tyr Gly Thr Ala Glu Leu Ile Gly Ile 
        195                 200                 205             


Ala Thr Gly Arg Thr Ala Leu Ser Thr Phe Pro Thr Pro Lys Gly Glu 
    210                 215                 220                 


Val Ser Leu Leu Gly Tyr His Glu Ser Lys Gly Asn Leu Pro Glu Gly 
225                 230                 235                 240 


Glu Arg Glu Ala Val Ala Ala Ser His Val Val Gln Val Arg Tyr Gly 
                245                 250                 255     


Arg Asp Thr Arg Ala Lys Pro Met Glu His Leu Ala Ala Leu Leu Gln 
            260                 265                 270         


Pro Met Phe Gly Phe Asp Thr Leu Ser Gln Ile Asp Ser Arg Leu Leu 
        275                 280                 285             


Glu Arg Ile Ala Arg Ser Leu Lys Trp Pro Val Gly Glu Arg Leu Lys 
    290                 295                 300                 


Ala Ala Ile Arg Leu Val Lys Gly Leu Lys Val Ser Glu Leu Asp Ala 
305                 310                 315                 320 


Cys Leu Gln Ala Val Glu Asp Thr Gln Arg Phe Ala Arg Asp Leu Lys 
                325                 330                 335     


Pro Glu Phe Arg Leu Leu Phe Arg Gly Ala Ala Val Ala Asp Ser Glu 
            340                 345                 350         


Arg Ala Val Leu Arg His Gly Ala Tyr Gln Gly Met Thr Arg Lys Leu 
        355                 360                 365             


Val Val Pro Leu Val Val Gly Gly Thr Ala Leu Glu Gln Ala Val Ala 
    370                 375                 380                 


Val Arg His Phe Glu Ala Val Glu Arg Val Cys Arg Gln Trp His Ser 
385                 390                 395                 400 


Asp Leu Pro Ser Trp Lys Thr Ala Pro Pro Ala Gly Asp Ala Glu Ala 
                405                 410                 415     


Leu Asn Gln Arg Leu Ala Gln Arg Lys Pro Glu Asn Ala Leu Leu Leu 
            420                 425                 430         


Ile Gly Leu Gly Arg Gly Ala Asp Lys Arg Lys Ile Arg Asn Val Ala 
        435                 440                 445             


Tyr Arg Tyr Gly Leu Ala Thr Gln Phe Met Arg Leu Asp His Pro Pro 
    450                 455                 460                 


Arg Thr Tyr Gln Ser Thr Tyr Tyr Asn Asn Leu Ala Ala Gly Val Phe 
465                 470                 475                 480 


Ser Lys Gly Gly Gly Val Leu Cys Ala Ile Asp Asp Met Pro Gly Glu 
                485                 490                 495     


Thr Asp Leu Phe Ile Gly Leu Asp Leu Gly Gly Val Ser Gln Arg Ala 
            500                 505                 510         


Pro Gly Leu Ala Phe Leu Phe Thr Arg Glu Gly Ala Gln Leu Gly Trp 
        515                 520                 525             


Gln Leu Ala Glu Ala Gln Arg Gly Glu Arg Val Glu Asp Ala Val Leu 
    530                 535                 540                 


Gly Asp Leu Leu Glu Arg Ser Leu Gln Ala Tyr Arg Gln Val His Leu 
545                 550                 555                 560 


Gly Ala Leu Pro Arg Arg Ile Ala Leu His Arg Asp Gly Arg Leu Phe 
                565                 570                 575     


Glu Ser Leu Asp Val Ile Arg Asn Phe Glu Arg Asp Tyr Ser Val Arg 
            580                 585                 590         


Val Asp Val Leu Glu Val Val Lys Ser Gly Cys Pro Pro Leu Tyr Arg 
        595                 600                 605             


Arg Gly Val Val Ala Glu Asn Lys Lys Ala Phe Arg Asn Pro Glu Val 
    610                 615                 620                 


Gly Asp Ala Phe Glu Leu Pro Gly Leu Asp Glu Leu Ile Ile Ala Thr 
625                 630                 635                 640 


Tyr Ser Gly Glu Glu Leu Gly Ser Ser Trp Gly Asp Lys Val Thr Val 
                645                 650                 655     


Arg Pro Leu Arg Leu Arg Lys Arg Tyr Gly Glu Thr Asp Leu His Thr 
            660                 665                 670         


Leu Ala Arg Gln Val Val Leu Leu Ser Arg Ile His Gly Ala Ser Leu 
        675                 680                 685             


Tyr Arg His Pro Arg Leu Pro Val Thr Thr His His Ala Asp Arg Phe 
    690                 695                 700                 


Ala Thr Leu Arg Gln Glu Cys Asn Leu Asp Asp Leu Ser Lys Met Asp 
705                 710                 715                 720 


Arg Leu Cys Pro Val Tyr Leu 
                725         


<210>  6

<211>  743
<212>  PRT
<213>  Pseudomonas luteola

<220>
<223>  Ago protein

<400>  6
Met Ser Lys Val Gly Ile Ala Ala Leu Gln Leu Glu Arg Asn Leu Gly 
1               5                   10                  15      


Ser Leu Pro Val Tyr Val Tyr Asp Leu Thr Phe Val Ser Ser Pro Ser 
            20                  25                  30          


Asp Gln Glu Pro Ile Gln Leu Thr Arg Arg Gly Ala Ser Gln Leu Ser 
        35                  40                  45              


Trp Val Asn Arg Gln Thr Ala Ile Thr Asp Phe Gly His Phe Lys Leu 
    50                  55                  60                  


Val Thr Leu Arg Pro Leu Ser Ala Tyr Glu Ala Asn Trp Gln Gly Val 
65                  70                  75                  80  


His Cys Val Val Gln Gly Glu Arg Glu Leu Thr Leu Ser Ala Glu Asn 
                85                  90                  95      


Glu Leu His Arg Glu Thr Ile Lys Arg Leu Val Asn Gln Cys Leu Met 
            100                 105                 110         


Gln Gly Thr Arg Gln Leu Ala Asn Val Ser Asn Gly Ala Met Gln Ala 
        115                 120                 125             


Glu Tyr Gly Gln Gly Tyr Gln Val Glu Leu Ile Asp Cys Leu Ala Ser 
    130                 135                 140                 


Ser Arg Val Ala Val Arg Asn Glu Phe Leu Asp Val Phe Gln Cys Leu 
145                 150                 155                 160 


Arg Leu Val Pro Glu Val Leu Pro Asp Gly Ser Thr Leu Val Ser Phe 
                165                 170                 175     


Met Val Arg His Arg Leu Leu Pro Arg Glu His Ile Thr Leu Asp Trp 
            180                 185                 190         


Val Ile Lys Thr Arg Pro Glu Trp Leu Glu Ser Ile Lys Arg Val Arg 
        195                 200                 205             


His Arg Tyr Ser Ser Gln Gly Lys Ala Pro Gly Ser Ala Asn Phe Ile 
    210                 215                 220                 


Ala Val Glu Lys Ser Arg Ser Ala Gln Ser Gln Ile Ser Thr Ala Gln 
225                 230                 235                 240 


Gly Lys Ile Ser Leu Phe Asp Tyr His Asp Gln Arg Gly Asn Ile Leu 
                245                 250                 255     


Pro Gly Glu Lys Ser Leu Ala Tyr Asp Ser Ser Val Val Lys Val Ser 
            260                 265                 270         


Tyr Gly Arg Ser Lys Glu Ser Phe Glu His Leu Ala Thr Leu Leu Gln 
        275                 280                 285             


Pro Met Phe Asp Phe Glu Ala Leu Gln Gly Ile Asp Ser Lys Leu Leu 
    290                 295                 300                 


Glu Arg Ile Ala Lys Gly Leu Lys Trp Pro Ile Ala Asp Arg Leu Glu 
305                 310                 315                 320 


Ala Ala Ala Gln Arg Ile Lys Asn Leu Lys Val Gly Glu Leu Ala Cys 
                325                 330                 335     


Gly Leu Thr Thr Val Arg Asn Leu Asp Glu Arg Val Gln Tyr Leu Arg 
            340                 345                 350         


Pro Pro Ile Arg Leu Arg Phe Ala Asn Asp Lys Ile Gly Asp His Glu 
        355                 360                 365             


Lys Leu Val Thr Lys His Gly Ala Phe Arg Gly Met Gln Arg Glu Leu 
    370                 375                 380                 


Val Val Pro Ile Val Ile Gly Gly Thr Asn Glu Glu Gln Gln Ala Ala 
385                 390                 395                 400 


Lys Gln His Phe Tyr Asn Val Glu Lys Ile Cys Gln Leu Trp Ser Asn 
                405                 410                 415     


Glu Ser Pro Arg Trp Lys Gln Val Pro Ser Ala Asn Asp Glu Leu Glu 
            420                 425                 430         


Leu Asp Ala Arg Leu Ser Ser Lys Thr Leu Pro Glu Ala Leu Leu Phe 
        435                 440                 445             


Ile Ala Leu Gly Arg Asn Ala Asn Lys Gln Ala Ile Arg Asn Val Ala 
    450                 455                 460                 


Tyr Arg Tyr Gly Leu Ala Thr Gln Phe Met Arg Leu Asp His Pro Ala 
465                 470                 475                 480 


Arg Ile Tyr Gln Gln Thr Tyr Tyr Asn Asn Leu Ala Ala Gly Leu Phe 
                485                 490                 495     


Ser Lys Ala Gly Gly Leu Ile Cys Gly Leu Asp Gln Met Pro Gly Asp 
            500                 505                 510         


Thr Asp Leu Phe Ile Gly Leu Asp Leu Gly Gly Val Gly Gln Arg Leu 
        515                 520                 525             


Pro Gly Thr Ala Phe Leu Phe Thr Arg Ser Gly Ala Gln Leu Gly Trp 
    530                 535                 540                 


Gln Leu Ala Glu Ala Gln Lys Gly Glu Arg Val Glu Asn Glu Val Leu 
545                 550                 555                 560 


His Asp Leu Leu Glu Arg Ser Leu Gln Ala Phe Val Arg Ala Asn Asp 
                565                 570                 575     


Gly Leu Leu Pro Gln Arg Ile Thr Leu His Arg Asp Gly His Leu Tyr 
            580                 585                 590         


Glu Ser Leu Asp Val Ile Lys Arg Phe Glu Gln Lys His Asn Val Gly 
        595                 600                 605             


Ile Asp Val Leu Glu Val Ile Lys Ser Gly Cys Pro Pro Leu Phe Arg 
    610                 615                 620                 


Arg Ser Gln Gly Pro Glu Gly Lys Ala Ile Tyr Ser Asn Pro Glu Val 
625                 630                 635                 640 


Gly Asp Ala Phe Glu Leu Ser Gly Leu Asp Glu Leu Ile Val Ala Thr 
                645                 650                 655     


Tyr Ser Ser Gln Asp Leu Gly Gln Ala Trp Gly Asp Lys Val Thr Val 
            660                 665                 670         


Arg Pro Leu Arg Leu Arg Lys Arg Tyr Gly Leu Thr Asp Leu His Thr 
        675                 680                 685             


Leu Ala Lys Gln Val Ile Leu Leu Ser Arg Ile His Gly Ala Ser Leu 
    690                 695                 700                 


Tyr Arg His Pro Arg Leu Pro Val Thr Thr His His Ala Asp Arg Phe 
705                 710                 715                 720 


Ala Ser Leu Arg Gln Glu Cys His Leu Asp Asp Leu Ser Arg Met Asp 
                725                 730                 735     


Arg Leu Cys Pro Val Tyr Leu 
            740             


<210>  7

<211>  738
<212>  PRT
<213>  Marinospirillum minutulum

<220>
<223>  Ago protein

<400>  7
Met Gly Leu Asn Lys Asn Leu Asn Gln Val Thr Val Tyr Arg Tyr Gln 
1               5                   10                  15      


Val Val Ile Glu Ser Ala Val Asp Glu Lys Asp Ser Ser Val Gln Leu 
            20                  25                  30          


Thr Arg Lys Val Ala Arg Leu Thr Ala Ser Lys Asn Gly Trp Gln Pro 
        35                  40                  45              


Val Thr Asp Ile Ser Ser Phe Ser Ile Ile Ser Leu Gln Pro Leu Lys 
    50                  55                  60                  


Leu Leu Thr Ile Gln Ala Phe Gly Leu Asn Phe Thr Leu Lys Gln Asp 
65                  70                  75                  80  


Gly Gln Leu Ala Leu Asn Ala Glu Lys Glu Asn Glu Arg Ala Ala Ile 
                85                  90                  95      


Glu Arg Leu Leu Asn Gln Asp Leu Tyr Ser Ala Val Tyr Arg Leu Ser 
            100                 105                 110         


Val Asp Arg Gly Arg Gln Gly Gly Lys Pro Phe Lys Ala Ile Arg His 
        115                 120                 125             


Arg Ala Gly Trp Ala Glu Ile Glu Glu Thr Gln Pro Ser Glu Arg Ile 
    130                 135                 140                 


Arg Val Asn Ser Asp Tyr Leu Asp Leu Phe Lys Thr Leu Arg Leu Ile 
145                 150                 155                 160 


Pro Glu Leu Leu Pro Asn Gly Gln Val Ile Leu Gly Leu Ser Leu Gly 
                165                 170                 175     


His Lys Ile Cys Ala Arg Asn Gly Ile Thr Leu Asp Trp Val Ile Lys 
            180                 185                 190         


Asn Arg Lys Gly Trp Leu Pro Asn Ile Lys Arg Val Arg His Arg Tyr 
        195                 200                 205             


Ser Asn Gln Gly Gln Ala Pro Ala Val Ala Asp Phe Tyr Gly Leu Val 
    210                 215                 220                 


Ala Asp Lys Thr Ala Glu Ser Leu Val Pro Gly Thr Glu Leu Ser Leu 
225                 230                 235                 240 


Tyr Lys Tyr His Ala Ser Lys Asn Asn Phe Ser Pro Glu Gln Gln Val 
                245                 250                 255     


Ser Val Ser Ala Ser Gln Val Val Ser Val Gly Tyr Gly Pro Lys His 
            260                 265                 270         


Lys Tyr Glu His Leu Ala Ala Leu Leu Glu Pro Met Phe Asp Phe Glu 
        275                 280                 285             


Thr Leu Gln Lys Ile Asp Ser Pro Leu Leu Asn Arg Ile Ala Gln Gly 
    290                 295                 300                 


Leu Lys Trp Pro Val Met Glu Arg Leu Arg Thr Ser Gly Glu Met Val 
305                 310                 315                 320 


Lys Gly Leu Met Leu Pro Ser Phe Ala Ala Gln Val Ile Gln Ala Lys 
                325                 330                 335     


Pro Leu Glu Gln Ala Val Glu Asn Ile Cys Pro Asn Phe Lys Leu Ser 
            340                 345                 350         


Phe Tyr Gln Gly Arg Pro Gly Ser Ser Glu Lys Asp Val Leu Arg Leu 
        355                 360                 365             


Lys Ala Phe Gln Gly Met Thr Leu Ser Gln Val Val Cys Leu Ala Val 
    370                 375                 380                 


Gly Thr Gln Ala Ser Pro Ala Asn Leu Ser Asn His Phe Ile Lys Leu 
385                 390                 395                 400 


Gln Ala Ala Cys Gln Arg Leu Ser Gly Glu Pro Leu Pro Glu Trp Arg 
                405                 410                 415     


Gly Val Thr Ser Val Gln Pro Leu Lys Asp Ala Met Glu Leu Asp Ala 
            420                 425                 430         


Arg Leu Ser Lys Lys Pro Gln Lys Asn Thr Leu Leu Val Ile Ala Ile 
        435                 440                 445             


Asp Lys Thr Val Asn Lys Ala Glu Val Arg Asp Val Ala Phe Arg His 
    450                 455                 460                 


Lys Leu Ala Cys Gln Phe Met Leu Thr Asp His Gln Pro Lys Thr Tyr 
465                 470                 475                 480 


Gln Pro Ser Tyr Tyr Asn Asn Leu Ala Ala Gly Val Phe Ser Lys Gly 
                485                 490                 495     


Gly Gly Leu Ile Cys Gly Leu Glu Glu Met Pro Gly Asp Val Asp Leu 
            500                 505                 510         


Phe Ile Gly Leu Asp Met Gly Gly Val Thr Gln Lys Ala Pro Gly Ser 
        515                 520                 525             


Ala Phe Leu Phe Thr Arg Asn Gly Ala Gln Leu Gly Trp Gln Leu Ala 
    530                 535                 540                 


Asp Leu Gln Lys Gly Glu Arg Leu Glu Asp Glu Ala Leu Lys Asn Leu 
545                 550                 555                 560 


Leu Ser Lys Ser Ile Gln Glu Tyr Ala Arg Asn His Glu Gly Ala Leu 
                565                 570                 575     


Pro Arg Lys Leu Val Val His Arg Asp Gly Arg Phe Phe Glu Ser Leu 
            580                 585                 590         


Asp Ile Val Gln Ala Ile Glu Arg Gln Tyr Gly Ile Asn Ile Ser Val 
        595                 600                 605             


Leu Glu Val Ile Lys Ser Gly Ala Pro Ile Leu Phe Arg Lys Tyr Gln 
    610                 615                 620                 


Gln Ala Gly Lys Met Gln Tyr Arg Asn Pro Glu Val Gly Asp Val Tyr 
625                 630                 635                 640 


Arg Tyr Leu Gly Leu Asp Glu Leu Ile Ile Ala Thr Tyr Ser Gly Gln 
                645                 650                 655     


Glu Leu Gly Ala Trp Gly Glu Lys Val Ser Val Arg Pro Leu Arg Leu 
            660                 665                 670         


Arg Lys Arg Tyr Gly Asp Glu Thr Leu Asp Asn Leu Ala Lys Gln Val 
        675                 680                 685             


Leu Leu Leu Thr Arg Ile His Gly Ala Ser Leu Tyr Arg His Pro Arg 
    690                 695                 700                 


Leu Pro Val Thr Thr His His Ala Asp Arg Phe Ala Thr Leu Arg Gln 
705                 710                 715                 720 


Ser Cys Ser Leu Glu Ala Leu Ser His Met Asp Arg Thr Cys Pro Val 
                725                 730                 735     


Tyr Leu 
        


<210>  8

<211>  749
<212>  PRT
<213>  Haloferax denitricans

<220>
<223>  Ago protein

<400>  8
Met Thr Asn Arg Ser Pro Gln Thr Asn Ser Arg Thr Pro Glu Arg Gln 
1               5                   10                  15      


Ala Asp Ile Asn Pro Gly Thr Tyr Val Leu His Gly Arg Gly Asn Arg 
            20                  25                  30          


Arg Leu Thr Asp Val Lys Val Asn Arg Tyr Glu Leu Arg Val Asp Gly 
        35                  40                  45              


Gly Val Glu Asn His Trp Asp Ser Gln Ser Phe Thr Ser Ser Ala Ala 
    50                  55                  60                  


Tyr Tyr Leu Asp Arg Thr His Gly Thr Pro Val Ala Ser Ala Gly Pro 
65                  70                  75                  80  


Leu Ser Val Ile Ser Val Thr Gly Leu Ser Lys Pro Val Asn Val Trp 
                85                  90                  95      


Gly Lys Arg Val Thr Pro Val Lys Thr Glu Thr Val Gln Leu Asp Pro 
            100                 105                 110         


Lys Lys Lys Arg Asp Arg Glu His Leu Arg Ala Phe Val Gln Ser Cys 
        115                 120                 125             


Leu Arg Arg Ala Val Pro Asp Asp Thr Tyr Ala Tyr Lys Phe Ile Asn 
    130                 135                 140                 


Asp Ile Val Arg Asn Asp Pro Ala Phe Ser Thr Gly Thr Asp Gly Phe 
145                 150                 155                 160 


Ala Ala His Pro Lys His Glu Val Lys Val Gln Ile Ala Ser Asp Gly 
                165                 170                 175     


Thr Val Leu Ala His Val Glu Ser Gly Tyr Ser Ile Lys Ser Lys Ser 
            180                 185                 190         


Thr Leu Asp Asn Leu Tyr Ser Pro Gly Ser Gln Leu Pro Asn Met Lys 
        195                 200                 205             


Val Ala His Asp Thr Asp Arg Tyr Ala Lys Glu Gly Gln Gly Trp Leu 
    210                 215                 220                 


Lys Gly Trp Ser Glu Phe Asn Tyr Thr Asp Tyr Ile Arg Asp Val Gly 
225                 230                 235                 240 


Ser Ser Ile Ala Glu Leu His Glu Gly Thr Ala Asp Glu Asp Trp Arg 
                245                 250                 255     


Gln Arg Leu Ile Glu Glu Asn Pro Arg Leu Val Lys Val Lys Tyr Gly 
            260                 265                 270         


Asn Met Val Gly Asn Gln Leu Pro His Phe Leu Arg Leu Ser Pro Arg 
        275                 280                 285             


Pro Glu Gln Val Gln Arg Gln Asp Tyr Asp Phe Phe Ser Gln Phe Ile 
    290                 295                 300                 


Ser Arg Arg Ala Met Met Pro Asp Glu Lys Tyr Asp Tyr Ser Lys Ser 
305                 310                 315                 320 


Phe Phe Glu Ser Leu Ser Arg Leu Pro Val Ile Asp Leu Glu Phe Glu 
                325                 330                 335     


Pro Gly Pro Thr Asn His Pro Tyr Lys Arg Ile Asn Val Arg Glu Gln 
            340                 345                 350         


Asn Thr Arg Leu Val Phe Ser Asp Asp Gln Gln Ser Asn Thr Pro Ser 
        355                 360                 365             


Gly Gly Leu Arg Glu Tyr Gly Val Tyr Ala Ser Pro Gly Arg Tyr Arg 
    370                 375                 380                 


Val Gly Leu Leu Met Pro Ser Gln Trp Glu Glu Thr Leu Gln Lys Leu 
385                 390                 395                 400 


Thr Pro Leu Leu Val Lys Gly Leu Asn Asn Ile Gly Ala Pro Ala Gly 
                405                 410                 415     


Val Thr Gly Tyr His Tyr Gly Leu Gly Asp Ile Ser Asn Tyr Thr Pro 
            420                 425                 430         


Val Ala His Glu Ile Arg Ser Glu Thr Asp Ala Val Val Ala Val Val 
        435                 440                 445             


Pro Asn Lys Gly Ala Ala Asp Asp Phe Gly Ile Asp Asp Pro His His 
    450                 455                 460                 


Glu Leu Lys Arg Thr Leu Met Arg Lys Gly Ile Pro Thr Gln Met Leu 
465                 470                 475                 480 


Gln Lys Ser Ser Ala Gln Glu Leu Ile Lys Gln Arg Ala Thr Pro Asn 
                485                 490                 495     


Asn Asp Lys Phe Leu Asn Ile Leu Ser Ala Ile Val Ala Lys Ala Gly 
            500                 505                 510         


Gly Thr Pro Trp Gln Val Asp Ser Leu Pro Gly Glu Thr Asp Ala Phe 
        515                 520                 525             


Met Gly Leu Asp Val Thr Arg Asp Ser Glu Ser Gly Gln His Ser Gly 
    530                 535                 540                 


Ala Ser Ala Ser Val Val Leu Ala Asp Gly Thr Thr Phe Ala Ala Glu 
545                 550                 555                 560 


Ser Thr Thr Gln Gln Gly Gly Glu Lys Phe Ala Ala Arg His Val Glu 
                565                 570                 575     


Gln Phe Val Arg Asp Leu Val Val Asp Phe Ala Glu Gly Gln Glu Arg 
            580                 585                 590         


Glu Ile Asn Arg Val Cys Ile Met Arg Asp Gly Lys Val His Glu Asp 
        595                 600                 605             


Ile Asp Ala Val Arg Glu Gly Leu Ser Glu Leu Asp Ala Glu Ile Asp 
    610                 615                 620                 


Ile Val Gly Val Arg Lys Arg Gly Gln Pro Arg Ile Ala Asp Tyr Asn 
625                 630                 635                 640 


Gly Thr Arg Phe Lys Ile Ala Tyr Lys Gly Met Ala Phe Val Asp Ala 
                645                 650                 655     


Asp Arg Asp Glu Ala Val Ile His Gly Phe Gly Lys Pro Glu Ile Arg 
            660                 665                 670         


Asp Asp Asn Pro Val Gly Thr Pro Gln Thr Phe Lys Leu Val Arg His 
        675                 680                 685             


Ser Gly Pro Thr Asp Ile Glu Thr Leu Ala Arg Gln Ala Tyr Trp Leu 
    690                 695                 700                 


Ser Glu Val His Val Gly Ser Pro Ala Lys Ser Pro Arg Leu Pro Ile 
705                 710                 715                 720 


Pro Ile Glu Tyr Ala Asp Lys Ala Ala Glu Tyr Val Arg Lys Glu Tyr 
                725                 730                 735     


Val Ser Pro Gly Lys Val Ile Lys Gly Pro Ala Tyr Ile 
            740                 745                 


<210>  9

<211>  306
<212>  PRT
<213>  Halorubrum kocurii

<220>
<223>  Ago protein

<400>  9
Met Leu Ala Val Val Pro Asn Lys Gly Val Ala Glu Asp Phe Gly Ile 
1               5                   10                  15      


Asp Asp Pro Tyr Lys Glu Leu Lys Arg Thr Leu Leu Arg Lys Gly Ile 
            20                  25                  30          


Pro Thr Gln Met Met Gln Lys Ser Thr Val Asp Glu Ile Val Gly Gln 
        35                  40                  45              


Lys Ala Gly Ile Gly Asn Asp Lys Phe Leu Asn Ala Leu Ser Ala Val 
    50                  55                  60                  


Val Ala Lys Val Gly Gly Thr Pro Trp Gln Ile Asp Ser Leu Pro Gly 
65                  70                  75                  80  


Lys Thr Asp Ala Phe Met Gly Leu Asp Val Thr Tyr Asp Glu Ser Ser 
                85                  90                  95      


Glu Gln His Ala Gly Ala Ser Ala Ser Val Val Leu Ala Asp Gly Thr 
            100                 105                 110         


Thr Phe Ala Ala Glu Ser Thr Thr Gln Gln Gly Gly Glu Lys Phe Ser 
        115                 120                 125             


Ala Arg His Val Glu Gln Phe Val Arg Asp Leu Val Phe Asp Phe Ala 
    130                 135                 140                 


Gly Glu Gln Gly Arg Asp Ile Asp Arg Leu Cys Ile Met Arg Asp Gly 
145                 150                 155                 160 


Lys Ile Ser Glu Asp Ile Asp Ala Val Arg Glu Gly Leu Ser Gly Ile 
                165                 170                 175     


Glu Ala Glu Ile Asp Ile Val Gly Ile Arg Lys Ser Gly Gln Pro Arg 
            180                 185                 190         


Ile Ala Glu Phe Asp Gly Thr Arg Phe Arg Ile Ala Glu Lys Gly Val 
        195                 200                 205             


Gly Phe Val Asp Ala Asp Arg Ser Gln Ser Ile Ile His Ala Phe Gly 
    210                 215                 220                 


Lys Pro Glu Ile His Asp Asp Asn Pro Val Gly Thr Pro Arg Thr Phe 
225                 230                 235                 240 


Arg Leu Thr Lys Asp Ser Gly Pro Thr Asp Val Glu Thr Leu Thr Arg 
                245                 250                 255     


Gln Ala Tyr Trp Leu Ser Glu Ile His Phe Gly Ser Pro Val Arg Ser 
            260                 265                 270         


Pro Arg Leu Pro Val Pro Ile Glu Tyr Ala Asp Met Ala Ala Glu Tyr 
        275                 280                 285             


Val Arg Glu Glu Tyr Val Ser Pro Gly Thr Val Ile Glu Gly Pro Ala 
    290                 295                 300                 


Tyr Ile 
305     


<210>  10

<211>  759
<212>  PRT
<213>  Halobacterium satilanarum

<220>
<223>  Ago protein

<400>  10
Met Gln Ala Glu Ile Asp Asp Ala Phe Ala Asp Val Pro Glu Ser Ala 
1               5                   10                  15      


Thr Glu Gln Thr Gly His Ala Leu Thr Thr Phe Arg Ser Glu Lys Ser 
            20                  25                  30          


Leu Ser Glu Phe Ala Val His Glu Tyr Thr Leu Lys Ala Lys Asp Gly 
        35                  40                  45              


Tyr Arg Pro Asp Asp His Gln Ala Ala Leu Arg Asp Thr Tyr Lys Ala 
    50                  55                  60                  


Arg Arg Asp Ile Leu Gly Glu Phe Glu Ser Ser Ser Pro Pro Val Ile 
65                  70                  75                  80  


Ala Val Arg Asp Ala Leu Ala Leu Ala Thr Pro Ser Pro Leu Pro Val 
                85                  90                  95      


Glu Asp Leu Glu Leu Lys Asn Phe Glu Met Val Asn Asp Gly Pro His 
            100                 105                 110         


Thr Leu Asp Tyr Thr Asp Tyr Ser Asp Lys Ala Val Thr Lys Gly Leu 
        115                 120                 125             


Ile Asp Ala Ser Leu Arg Arg Ile Leu Asp Gly Asp Tyr Glu Val Arg 
    130                 135                 140                 


Gly Ile Asp Thr Val Leu Ser Lys Arg Pro Val Ile Gln Lys Gln Asp 
145                 150                 155                 160 


Phe Arg Leu His Glu Arg Trp Asn Leu Ser Leu Ser Val Thr Asn Ala 
                165                 170                 175     


Gly Val Val Tyr Leu Ser Val Asp Phe Arg His Lys Thr Ile Ser Glu 
            180                 185                 190         


Tyr Thr Leu Asp Lys Phe Asp Leu Asp Lys Leu Tyr Arg Gly Leu Arg 
        195                 200                 205             


Val Asn Val Thr Tyr Lys Gln Ser Gly Lys Gly Ala Phe Val Asp Glu 
    210                 215                 220                 


Leu Met Asp Lys Thr Val Asn Glu Ser Ile Asp Asp Met Gly Asn Gln 
225                 230                 235                 240 


Ser Val Val Glu Tyr His Glu Gly Ala Glu Arg Ile Pro Asp Arg Val 
                245                 250                 255     


Leu Lys Glu Ile Ala Arg Ala Asp Arg Arg Val Val Lys Val Thr Lys 
            260                 265                 270         


Gln Gly Ser His Asn Thr Glu Tyr Tyr Pro Gln Arg Leu Leu Ala Leu 
        275                 280                 285             


Gln Gly His Pro Gln Asn Val Lys Ala Phe Ala Pro Arg Phe Asn Glu 
    290                 295                 300                 


Ala Thr Arg Gly Lys Thr Arg Leu Ser Ala Gln Arg Cys Leu Asn Arg 
305                 310                 315                 320 


Ala Thr Thr Phe Val Glu Asn Leu Pro Pro Val Ile Pro Leu Gly Gly 
                325                 330                 335     


Ala Thr Leu Ser Phe Asp Ala Thr Pro Val Asn Gly Asp Asp Thr Trp 
            340                 345                 350         


Glu Met Ser Arg Leu Phe Glu Thr Asp Ala His Ile Leu Gln Phe Ala 
        355                 360                 365             


Glu Glu Gln Thr Gly Asp His Pro Arg Arg Val Lys His Asn Glu Val 
    370                 375                 380                 


Tyr Glu Ala Pro Glu Glu Phe Ser Val Cys Leu Val His Pro Ser Ala 
385                 390                 395                 400 


Gly Pro His Ala Glu Arg Trp Glu Asn Leu Asp Gln Gln Leu Lys Asp 
                405                 410                 415     


Ile Gly Ala Gly Pro Glu Ala Val Asn Arg Val Gln Tyr Asp Pro Phe 
            420                 425                 430         


Lys Thr Ala Asp Glu Ile Tyr Thr Asp Leu Leu Val Asp Val Pro Asp 
        435                 440                 445             


Asp His Glu Tyr Ser Ala Ala Cys Val Ile Leu Pro Lys Ala Asp Phe 
    450                 455                 460                 


Ser Met Gly Glu Ser Ser Ala Ser Asp Ile Tyr His Glu Met Lys Lys 
465                 470                 475                 480 


Ala Leu Arg Gln Arg Arg Val Asp Ser Gln Met Ala His Ile Asp Thr 
                485                 490                 495     


Leu Ala Thr Ser Tyr Ala Leu Pro Asn Val Ala Leu Gly Leu Val Ala 
            500                 505                 510         


Ala Ala Gly Gly Ile Pro Phe Thr Thr Glu Asp Ala Met Pro Gly Glu 
        515                 520                 525             


Thr Asp Leu Phe Ile Gly Ile Asp Val Ser His Arg Tyr Pro Arg Asp 
    530                 535                 540                 


Thr Asp Glu Arg Val His Ile Ala Ala Ser Thr Thr Ser Ile Tyr Gly 
545                 550                 555                 560 


Asp Gly Thr Ile Leu Gly Tyr Thr Ser Ala Lys Pro Gln Thr Gly Glu 
                565                 570                 575     


Lys Val Pro Pro Lys Glu Leu Lys Asn Leu Thr Arg Gln Ser Ile Ala 
            580                 585                 590         


Gly Tyr Lys Gln Glu His Gly Glu Tyr Pro Asp Arg Ile Val Ile His 
        595                 600                 605             


Arg Asp Gly Phe Met Arg Glu Asp Leu Asp Gln Val Glu Glu Met Leu 
    610                 615                 620                 


Glu Ser Met Asp Ile Asn Tyr Asp Val Val Glu Ile Arg Lys Gln Ser 
625                 630                 635                 640 


Pro Ala Arg Val Leu Asn Leu Ala Asp Gly Val Ala Lys Ile Pro Asp 
                645                 650                 655     


Lys Gly Ile Ala Ala Leu Asn Arg Glu Glu Asn Arg Ala Ile Leu Ala 
            660                 665                 670         


Thr Phe Gly Asp Pro Glu Ser Gln Ala Thr Ser Ser Asn Thr Gly Leu 
        675                 680                 685             


Pro Gln Pro Ile Gln Val Glu Arg Lys Ala Gly Asp Thr Asp Ile Lys 
    690                 695                 700                 


Thr Leu Thr Ala Gln Val Tyr Leu Leu Ser Gln Ser His Val Gly Ala 
705                 710                 715                 720 


Met Asn Ser Thr Ala Arg Leu Pro Ile Thr Thr Tyr Tyr Ala Asp Arg 
                725                 730                 735     


Ala Ser Glu Ala Ala Ala Glu Gly Tyr Leu Pro Glu Thr Ser Lys Leu 
            740                 745                 750         


Arg Gln Asn Ile Gly Phe Ile 
        755                 


<210>  11

<211>  887
<212>  PRT
<213>  Natronobacterium gregoryi

<220>
<223>  Ago protein

<400>  11
Met Thr Val Ile Asp Leu Asp Ser Thr Thr Thr Ala Asp Glu Leu Thr 
1               5                   10                  15      


Ser Gly His Thr Tyr Asp Ile Ser Val Thr Leu Thr Gly Val Tyr Asp 
            20                  25                  30          


Asn Thr Asp Glu Gln His Pro Arg Met Ser Leu Ala Phe Glu Gln Asp 
        35                  40                  45              


Asn Gly Glu Arg Arg Tyr Ile Thr Leu Trp Lys Asn Thr Thr Pro Lys 
    50                  55                  60                  


Asp Val Phe Thr Tyr Asp Tyr Ala Thr Gly Ser Thr Tyr Ile Phe Thr 
65                  70                  75                  80  


Asn Ile Asp Tyr Glu Val Lys Asp Gly Tyr Glu Asn Leu Thr Ala Thr 
                85                  90                  95      


Tyr Gln Thr Thr Val Glu Asn Ala Thr Ala Gln Glu Val Gly Thr Thr 
            100                 105                 110         


Asp Glu Asp Glu Thr Phe Ala Gly Gly Glu Pro Leu Asp His His Leu 
        115                 120                 125             


Asp Asp Ala Leu Asn Glu Thr Pro Asp Asp Ala Glu Thr Glu Ser Asp 
    130                 135                 140                 


Ser Gly His Val Met Thr Ser Phe Ala Ser Arg Asp Gln Leu Pro Glu 
145                 150                 155                 160 


Trp Thr Leu His Thr Tyr Thr Leu Thr Ala Thr Asp Gly Ala Lys Thr 
                165                 170                 175     


Asp Thr Glu Tyr Ala Arg Arg Thr Leu Ala Tyr Thr Val Arg Gln Glu 
            180                 185                 190         


Leu Tyr Thr Asp His Asp Ala Ala Pro Val Ala Thr Asp Gly Leu Met 
        195                 200                 205             


Leu Leu Thr Pro Glu Pro Leu Gly Glu Thr Pro Leu Asp Leu Asp Cys 
    210                 215                 220                 


Gly Val Arg Val Glu Ala Asp Glu Thr Arg Thr Leu Asp Tyr Thr Thr 
225                 230                 235                 240 


Ala Lys Asp Arg Leu Leu Ala Arg Glu Leu Val Glu Glu Gly Leu Lys 
                245                 250                 255     


Arg Ser Leu Trp Asp Asp Tyr Leu Val Arg Gly Ile Asp Glu Val Leu 
            260                 265                 270         


Ser Lys Glu Pro Val Leu Thr Cys Asp Glu Phe Asp Leu His Glu Arg 
        275                 280                 285             


Tyr Asp Leu Ser Val Glu Val Gly His Ser Gly Arg Ala Tyr Leu His 
    290                 295                 300                 


Ile Asn Phe Arg His Arg Phe Val Pro Lys Leu Thr Leu Ala Asp Ile 
305                 310                 315                 320 


Asp Asp Asp Asn Ile Tyr Pro Gly Leu Arg Val Lys Thr Thr Tyr Arg 
                325                 330                 335     


Pro Arg Arg Gly His Ile Val Trp Gly Leu Arg Asp Glu Cys Ala Thr 
            340                 345                 350         


Asp Ser Leu Asn Thr Leu Gly Asn Gln Ser Val Val Ala Tyr His Arg 
        355                 360                 365             


Asn Asn Gln Thr Pro Ile Asn Thr Asp Leu Leu Asp Ala Ile Glu Ala 
    370                 375                 380                 


Ala Asp Arg Arg Val Val Glu Thr Arg Arg Gln Gly His Gly Asp Asp 
385                 390                 395                 400 


Ala Val Ser Phe Pro Gln Glu Leu Leu Ala Val Glu Pro Asn Thr His 
                405                 410                 415     


Gln Ile Lys Gln Phe Ala Ser Asp Gly Phe His Gln Gln Ala Arg Ser 
            420                 425                 430         


Lys Thr Arg Leu Ser Ala Ser Arg Cys Ser Glu Lys Ala Gln Ala Phe 
        435                 440                 445             


Ala Glu Arg Leu Asp Pro Val Arg Leu Asn Gly Ser Thr Val Glu Phe 
    450                 455                 460                 


Ser Ser Glu Phe Phe Thr Gly Asn Asn Glu Gln Gln Leu Arg Leu Leu 
465                 470                 475                 480 


Tyr Glu Asn Gly Glu Ser Val Leu Thr Phe Arg Asp Gly Ala Arg Gly 
                485                 490                 495     


Ala His Pro Asp Glu Thr Phe Ser Lys Gly Ile Val Asn Pro Pro Glu 
            500                 505                 510         


Ser Phe Glu Val Ala Val Val Leu Pro Glu Gln Gln Ala Asp Thr Cys 
        515                 520                 525             


Lys Ala Gln Trp Asp Thr Met Ala Asp Leu Leu Asn Gln Ala Gly Ala 
    530                 535                 540                 


Pro Pro Thr Arg Ser Glu Thr Val Gln Tyr Asp Ala Phe Ser Ser Pro 
545                 550                 555                 560 


Glu Ser Ile Ser Leu Asn Val Ala Gly Ala Ile Asp Pro Ser Glu Val 
                565                 570                 575     


Asp Ala Ala Phe Val Val Leu Pro Pro Asp Gln Glu Gly Phe Ala Asp 
            580                 585                 590         


Leu Ala Ser Pro Thr Glu Thr Tyr Asp Glu Leu Lys Lys Ala Leu Ala 
        595                 600                 605             


Asn Met Gly Ile Tyr Ser Gln Met Ala Tyr Phe Asp Arg Phe Arg Asp 
    610                 615                 620                 


Ala Lys Ile Phe Tyr Thr Arg Asn Val Ala Leu Gly Leu Leu Ala Ala 
625                 630                 635                 640 


Ala Gly Gly Val Ala Phe Thr Thr Glu His Ala Met Pro Gly Asp Ala 
                645                 650                 655     


Asp Met Phe Ile Gly Ile Asp Val Ser Arg Ser Tyr Pro Glu Asp Gly 
            660                 665                 670         


Ala Ser Gly Gln Ile Asn Ile Ala Ala Thr Ala Thr Ala Val Tyr Lys 
        675                 680                 685             


Asp Gly Thr Ile Leu Gly His Ser Ser Thr Arg Pro Gln Leu Gly Glu 
    690                 695                 700                 


Lys Leu Gln Ser Thr Asp Val Arg Asp Ile Met Lys Asn Ala Ile Leu 
705                 710                 715                 720 


Gly Tyr Gln Gln Val Thr Gly Glu Ser Pro Thr His Ile Val Ile His 
                725                 730                 735     


Arg Asp Gly Phe Met Asn Glu Asp Leu Asp Pro Ala Thr Glu Phe Leu 
            740                 745                 750         


Asn Glu Gln Gly Val Glu Tyr Asp Ile Val Glu Ile Arg Lys Gln Pro 
        755                 760                 765             


Gln Thr Arg Leu Leu Ala Val Ser Asp Val Gln Tyr Asp Thr Pro Val 
    770                 775                 780                 


Lys Ser Ile Ala Ala Ile Asn Gln Asn Glu Pro Arg Ala Thr Val Ala 
785                 790                 795                 800 


Thr Phe Gly Ala Pro Glu Tyr Leu Ala Thr Arg Asp Gly Gly Gly Leu 
                805                 810                 815     


Pro Arg Pro Ile Gln Ile Glu Arg Val Ala Gly Glu Thr Asp Ile Glu 
            820                 825                 830         


Thr Leu Thr Arg Gln Val Tyr Leu Leu Ser Gln Ser His Ile Gln Val 
        835                 840                 845             


His Asn Ser Thr Ala Arg Leu Pro Ile Thr Thr Ala Tyr Ala Asp Gln 
    850                 855                 860                 


Ala Ser Thr His Ala Thr Lys Gly Tyr Leu Val Gln Thr Gly Ala Phe 
865                 870                 875                 880 


Glu Ser Asn Val Gly Phe Leu 
                885         


<210>  12

<211>  748
<212>  PRT
<213>  Clostridium butyricum

<220>
<223>  Ago protein

<400>  12
Met Asn Asn Leu Thr Phe Glu Ala Phe Glu Gly Ile Gly Gln Leu Asn 
1               5                   10                  15      


Glu Leu Asn Phe Tyr Lys Tyr Arg Leu Ile Gly Lys Gly Gln Ile Asp 
            20                  25                  30          


Asn Val His Gln Ala Ile Trp Ser Val Lys Tyr Lys Leu Gln Ala Asn 
        35                  40                  45              


Asn Phe Phe Lys Pro Val Phe Val Lys Gly Glu Ile Leu Tyr Ser Leu 
    50                  55                  60                  


Asp Glu Leu Lys Val Ile Pro Glu Phe Glu Asn Val Glu Val Ile Leu 
65                  70                  75                  80  


Asp Gly Asn Ile Ile Leu Ser Ile Ser Glu Asn Thr Asp Ile Tyr Lys 
                85                  90                  95      


Asp Val Ile Val Phe Tyr Ile Asn Asn Ala Leu Lys Asn Ile Lys Asp 
            100                 105                 110         


Ile Thr Asn Tyr Arg Lys Tyr Ile Thr Lys Asn Thr Asp Glu Ile Ile 
        115                 120                 125             


Cys Lys Ser Ile Leu Thr Thr Asn Leu Lys Tyr Gln Tyr Met Lys Ser 
    130                 135                 140                 


Glu Lys Gly Phe Lys Leu Gln Arg Lys Phe Lys Ile Ser Pro Val Val 
145                 150                 155                 160 


Phe Arg Asn Gly Lys Val Ile Leu Tyr Leu Asn Cys Ser Ser Asp Phe 
                165                 170                 175     


Ser Thr Asp Lys Ser Ile Tyr Glu Met Leu Asn Asp Gly Leu Gly Val 
            180                 185                 190         


Val Gly Leu Gln Val Lys Asn Lys Trp Thr Asn Ala Asn Gly Asn Ile 
        195                 200                 205             


Phe Ile Glu Lys Val Leu Asp Asn Thr Ile Ser Asp Pro Gly Thr Ser 
    210                 215                 220                 


Gly Lys Leu Gly Gln Ser Leu Ile Asp Tyr Tyr Ile Asn Gly Asn Gln 
225                 230                 235                 240 


Lys Tyr Arg Val Glu Lys Phe Thr Asp Glu Asp Lys Asn Ala Lys Val 
                245                 250                 255     


Ile Gln Ala Lys Ile Lys Asn Lys Thr Tyr Asn Tyr Ile Pro Gln Ala 
            260                 265                 270         


Leu Thr Pro Val Ile Thr Arg Glu Tyr Leu Ser His Thr Asp Lys Lys 
        275                 280                 285             


Phe Ser Lys Gln Ile Glu Asn Val Ile Lys Met Asp Met Asn Tyr Arg 
    290                 295                 300                 


Tyr Gln Thr Leu Lys Ser Phe Val Glu Asp Ile Gly Val Ile Lys Glu 
305                 310                 315                 320 


Leu Asn Asn Leu His Phe Lys Asn Gln Tyr Tyr Thr Asn Phe Asp Phe 
                325                 330                 335     


Met Gly Phe Glu Ser Gly Val Leu Glu Glu Pro Val Leu Met Gly Ala 
            340                 345                 350         


Asn Gly Lys Ile Lys Asp Lys Lys Gln Ile Phe Ile Asn Gly Phe Phe 
        355                 360                 365             


Lys Asn Pro Lys Glu Asn Val Lys Phe Gly Val Leu Tyr Pro Glu Gly 
    370                 375                 380                 


Cys Met Glu Asn Ala Gln Ser Ile Ala Arg Ser Ile Leu Asp Phe Ala 
385                 390                 395                 400 


Thr Ala Gly Lys Tyr Asn Lys Gln Glu Asn Lys Tyr Ile Ser Lys Asn 
                405                 410                 415     


Leu Met Asn Ile Gly Phe Lys Pro Ser Glu Cys Ile Phe Glu Ser Tyr 
            420                 425                 430         


Lys Leu Gly Asp Ile Thr Glu Tyr Lys Ala Thr Ala Arg Lys Leu Lys 
        435                 440                 445             


Glu His Glu Lys Val Gly Phe Val Ile Ala Val Ile Pro Asp Met Asn 
    450                 455                 460                 


Glu Leu Glu Val Glu Asn Pro Tyr Asn Pro Phe Lys Lys Val Trp Ala 
465                 470                 475                 480 


Lys Leu Asn Ile Pro Ser Gln Met Ile Thr Leu Lys Thr Thr Glu Lys 
                485                 490                 495     


Phe Lys Asn Ile Val Asp Lys Ser Gly Leu Tyr Tyr Leu His Asn Ile 
            500                 505                 510         


Ala Leu Asn Ile Leu Gly Lys Ile Gly Gly Ile Pro Trp Ile Ile Lys 
        515                 520                 525             


Asp Met Pro Gly Asn Ile Asp Cys Phe Ile Gly Leu Asp Val Gly Thr 
    530                 535                 540                 


Arg Glu Lys Gly Ile His Phe Pro Ala Cys Ser Val Leu Phe Asp Lys 
545                 550                 555                 560 


Tyr Gly Lys Leu Ile Asn Tyr Tyr Lys Pro Thr Ile Pro Gln Ser Gly 
                565                 570                 575     


Glu Lys Ile Ala Glu Thr Ile Leu Gln Glu Ile Phe Asp Asn Val Leu 
            580                 585                 590         


Ile Ser Tyr Lys Glu Glu Asn Gly Glu Tyr Pro Lys Asn Ile Val Ile 
        595                 600                 605             


His Arg Asp Gly Phe Ser Arg Glu Asn Ile Asp Trp Tyr Lys Glu Tyr 
    610                 615                 620                 


Phe Asp Lys Lys Gly Ile Lys Phe Asn Ile Ile Glu Val Lys Lys Asn 
625                 630                 635                 640 


Ile Pro Val Lys Ile Ala Lys Val Val Gly Ser Asn Ile Cys Asn Pro 
                645                 650                 655     


Ile Lys Gly Ser Tyr Val Leu Lys Asn Asp Lys Ala Phe Ile Val Thr 
            660                 665                 670         


Thr Asp Ile Lys Asp Gly Val Ala Ser Pro Asn Pro Leu Lys Ile Glu 
        675                 680                 685             


Lys Thr Tyr Gly Asp Val Glu Met Lys Ser Ile Leu Glu Gln Ile Tyr 
    690                 695                 700                 


Ser Leu Ser Gln Ile His Val Gly Ser Thr Lys Ser Leu Arg Leu Pro 
705                 710                 715                 720 


Ile Thr Thr Gly Tyr Ala Asp Lys Ile Cys Lys Ala Ile Glu Tyr Ile 
                725                 730                 735     


Pro Gln Gly Val Val Asp Asn Arg Leu Phe Phe Leu 
            740                 745             


<210>  13

<211>  705
<212>  PRT
<213>  Clostridium sartagoforme

<220>
<223>  Ago protein

<400>  13
Met Lys Glu Phe Asn Val Ile Thr Glu Phe Lys Asn Gly Ile Asn Ser 
1               5                   10                  15      


Lys Ser Ile Glu Ile Tyr Ile Tyr Lys Met Met Val Arg Asp Phe Glu 
            20                  25                  30          


Lys Arg His Asn Glu Asn Tyr Asp Val Val Lys Glu Leu Ile Asn Leu 
        35                  40                  45              


Asn Asn Asn Ser Thr Ile Val Phe Tyr Glu Gln Tyr Ile Ala Ser Phe 
    50                  55                  60                  


Lys Glu Ile Glu Lys Trp Gly Asn Glu Gln Tyr Ile Asn Val Glu Lys 
65                  70                  75                  80  


Arg Ala Ile Asn Leu Glu Ser Asn Glu Lys Lys Ile Leu Glu Arg Leu 
                85                  90                  95      


Leu Leu Lys Glu Ile Lys Asn Asn Ile Asp Asn Asn Lys Tyr Lys Val 
            100                 105                 110         


Val Lys Asp Ser Ile Tyr Ile Asn Lys Pro Val Tyr Asn Glu Lys Gly 
        115                 120                 125             


Ile Lys Ile Asp Arg Tyr Phe Asn Leu Asp Ile Asn Val Glu Ser Asn 
    130                 135                 140                 


Gly Asp Ile Ile Ile Gly Phe Asp Ile Ser His Asn Phe Glu Tyr Ile 
145                 150                 155                 160 


Asn Thr Leu Glu Tyr Glu Ile Lys Asn Asn Asn Ile Lys Ile Gly Asp 
                165                 170                 175     


Arg Val Lys Asp Tyr Phe Tyr Asn Leu Thr Tyr Glu Tyr Val Gly Ile 
            180                 185                 190         


Ala Pro Phe Thr Ile Ser Glu Glu Asn Glu Tyr Met Gly Cys Ser Ile 
        195                 200                 205             


Val Asp Tyr Tyr Glu Asn Lys Asn Gln Ser Tyr Ile Val Asn Lys Leu 
    210                 215                 220                 


Pro Lys Asp Met Lys Ala Ile Leu Val Lys Asn Asn Lys Asn Ser Ile 
225                 230                 235                 240 


Phe Pro Tyr Ile Pro Ser Arg Leu Lys Lys Val Cys Arg Phe Glu Asn 
                245                 250                 255     


Leu Pro Gln Asn Val Leu Arg Asp Phe Asn Thr Arg Val Lys Gln Lys 
            260                 265                 270         


Thr Asn Glu Lys Met Gln Phe Met Val Asp Glu Val Ile Asn Ile Val 
        275                 280                 285             


Lys Asn Ser Glu His Ile Asp Val Lys Lys Lys Asn Met Met Cys Asp 
    290                 295                 300                 


Asn Ile Gly Tyr Lys Ile Glu Asp Leu Gln Gln Pro Asp Leu Leu Phe 
305                 310                 315                 320 


Gly Asn Ala Arg Ala Gln Arg Tyr Pro Leu Tyr Gly Leu Lys Asn Phe 
                325                 330                 335     


Gly Val Tyr Glu Asn Lys Arg Ile Glu Ile Lys Tyr Phe Ile Asp Pro 
            340                 345                 350         


Ile Leu Ala Lys Ser Lys Met Asn Leu Glu Lys Ile Ser Lys Phe Cys 
        355                 360                 365             


Asp Glu Leu Glu Gln Phe Ser Ser Lys Leu Gly Val Gly Leu Asn Arg 
    370                 375                 380                 


Val Lys Leu Asn Asn Ile Val Asn Phe Lys Glu Ile Arg Met Asp Asn 
385                 390                 395                 400 


Glu Asp Ile Phe Ser Tyr Glu Ile Arg Lys Ile Val Ser Asn Tyr Asn 
                405                 410                 415     


Glu Thr Thr Ile Val Ile Leu Ser Glu Glu Asn Leu Asn Lys Tyr Tyr 
            420                 425                 430         


Asn Ile Ile Lys Lys Thr Phe Ser Gly Gly Asn Glu Val Pro Thr Gln 
        435                 440                 445             


Cys Ile Gly Phe Asn Thr Leu Ser Tyr Thr Glu Lys Asn Lys Asp Ser 
    450                 455                 460                 


Ile Phe Leu Asn Ile Leu Leu Gly Val Tyr Ala Lys Ser Gly Ile Gln 
465                 470                 475                 480 


Pro Trp Ile Leu Asn Glu Lys Leu Asn Ser Asp Cys Phe Ile Gly Leu 
                485                 490                 495     


Asp Val Ser Arg Glu Asn Lys Val Asn Lys Ala Gly Val Ile Gln Val 
            500                 505                 510         


Val Gly Lys Asp Gly Arg Val Leu Lys Thr Lys Val Ile Ser Ser Ser 
        515                 520                 525             


Gln Ser Gly Glu Lys Ile Lys Leu Glu Thr Leu Arg Glu Ile Val Phe 
    530                 535                 540                 


Glu Ala Ile Asn Ser Tyr Glu Asn Thr Tyr Arg Cys Lys Pro Lys His 
545                 550                 555                 560 


Ile Thr Phe His Arg Asp Gly Ile Asn Arg Glu Glu Leu Glu Asn Leu 
                565                 570                 575     


Lys Asn Thr Met Thr Asn Leu Gly Val Glu Phe Asp Tyr Ile Glu Ile 
            580                 585                 590         


Thr Lys Gly Ile Asn Arg Arg Ile Ala Thr Ile Ser Glu Gly Glu Glu 
        595                 600                 605             


Trp Lys Thr Ile Met Gly Arg Cys Tyr Tyr Lys Asp Asn Ser Ala Tyr 
    610                 615                 620                 


Val Cys Thr Thr Lys Pro Tyr Glu Gly Ile Gly Met Ala Lys Pro Ile 
625                 630                 635                 640 


Arg Ile Arg Arg Val Phe Gly Thr Leu Asp Ile Glu Lys Ile Val Glu 
                645                 650                 655     


Asp Ala Tyr Lys Leu Thr Phe Met His Val Gly Ala Ile Asn Lys Ile 
            660                 665                 670         


Arg Leu Pro Ile Thr Thr Tyr Tyr Ala Asp Leu Ser Ser Thr Tyr Gly 
        675                 680                 685             


Asn Arg Asp Leu Ile Pro Thr Asn Ile Asp Thr Asn Cys Leu Tyr Phe 
    690                 695                 700                 


Ile 
705 


<210>  14

<211>  759
<212>  PRT
<213>  Halobacterium sp. DL1

<220>
<223>  Ago protein

<400>  14
Met Gln Ala Glu Ile Asp Asp Ala Phe Ala Asp Val Pro Glu Ser Ala 
1               5                   10                  15      


Thr Glu Gln Thr Gly His Ala Leu Thr Thr Phe Arg Ser Glu Lys Ser 
            20                  25                  30          


Leu Ser Glu Phe Ala Val His Glu Tyr Thr Leu Lys Ala Lys Asp Gly 
        35                  40                  45              


Tyr Arg Pro Asp Asp His Gln Ala Ala Leu Arg Asp Thr Tyr Lys Ala 
    50                  55                  60                  


Arg Arg Asp Ile Leu Gly Glu Phe Glu Ser Ser Ser Pro Pro Val Ile 
65                  70                  75                  80  


Ala Val Arg Asp Ala Leu Ala Leu Ala Thr Pro Ser Pro Leu Pro Val 
                85                  90                  95      


Glu Asp Leu Glu Leu Lys Asn Phe Glu Met Val Asn Asp Gly Pro His 
            100                 105                 110         


Thr Leu Asp Tyr Thr Asp Tyr Ser Asp Lys Ala Val Thr Lys Gly Leu 
        115                 120                 125             


Ile Asp Ala Ser Leu Arg Arg Ile Leu Asp Gly Asp Tyr Glu Val Arg 
    130                 135                 140                 


Gly Ile Asp Thr Val Leu Ser Lys Arg Pro Val Ile Gln Lys Gln Asp 
145                 150                 155                 160 


Phe Arg Leu His Glu Arg Trp Asn Leu Ser Leu Ser Val Thr Asn Ala 
                165                 170                 175     


Gly Val Val Tyr Leu Ser Val Asp Phe Arg His Lys Thr Ile Ser Glu 
            180                 185                 190         


Tyr Thr Leu Asp Lys Phe Asp Leu Asp Lys Leu Tyr Arg Gly Leu Arg 
        195                 200                 205             


Val Asn Val Thr Tyr Lys Gln Ser Gly Lys Gly Ala Phe Val Asp Glu 
    210                 215                 220                 


Leu Met Asp Lys Thr Val Asn Glu Ser Ile Asp Asp Met Gly Asn Gln 
225                 230                 235                 240 


Ser Val Val Glu Tyr His Glu Gly Ala Glu Arg Ile Pro Asp Arg Val 
                245                 250                 255     


Leu Lys Glu Ile Ala Arg Ala Asp Arg Arg Val Val Lys Val Thr Lys 
            260                 265                 270         


Gln Gly Ser His Asn Thr Glu Tyr Tyr Pro Gln Arg Leu Leu Ala Leu 
        275                 280                 285             


Gln Gly His Pro Gln Asn Val Lys Ala Phe Ala Pro Arg Phe Asn Glu 
    290                 295                 300                 


Ala Thr Arg Gly Lys Thr Arg Leu Ser Ala Gln Arg Cys Leu Asn Arg 
305                 310                 315                 320 


Ala Thr Thr Phe Val Glu Asn Leu Pro Pro Val Ile Pro Leu Gly Gly 
                325                 330                 335     


Ala Thr Leu Ser Phe Asp Ala Thr Pro Val Asn Gly Asp Asp Thr Trp 
            340                 345                 350         


Glu Met Ser Arg Leu Phe Glu Thr Asp Ala His Ile Leu Gln Phe Ala 
        355                 360                 365             


Glu Glu Gln Thr Gly Asp His Pro Arg Arg Val Lys His Asn Glu Val 
    370                 375                 380                 


Tyr Glu Ala Pro Glu Glu Phe Ser Val Cys Leu Val His Pro Ser Ala 
385                 390                 395                 400 


Gly Pro His Ala Glu Arg Trp Glu Asn Leu Asp Gln Gln Leu Lys Asp 
                405                 410                 415     


Ile Gly Ala Gly Pro Glu Ala Val Asn Arg Val Gln Tyr Asp Pro Phe 
            420                 425                 430         


Lys Thr Ala Asp Glu Ile Tyr Thr Asp Leu Leu Val Asp Val Pro Asp 
        435                 440                 445             


Asp His Glu Tyr Ser Ala Ala Cys Val Ile Leu Pro Lys Ala Asp Phe 
    450                 455                 460                 


Ser Met Gly Glu Ser Ser Ala Ser Asp Ile Tyr His Glu Met Lys Lys 
465                 470                 475                 480 


Ala Leu Arg Gln Arg Arg Val Asp Ser Gln Met Ala His Ile Asp Thr 
                485                 490                 495     


Leu Ala Thr Ser Tyr Ala Leu Pro Asn Val Ala Leu Gly Leu Val Ala 
            500                 505                 510         


Ala Ala Gly Gly Ile Pro Phe Thr Thr Glu Asp Ala Met Pro Gly Glu 
        515                 520                 525             


Thr Asp Leu Phe Ile Gly Ile Asp Val Ser His Arg Tyr Pro Arg Asp 
    530                 535                 540                 


Thr Asp Glu Arg Val His Ile Ala Ala Ser Thr Thr Ser Ile Tyr Gly 
545                 550                 555                 560 


Asp Gly Thr Ile Leu Gly Tyr Thr Ser Ala Lys Pro Gln Thr Gly Glu 
                565                 570                 575     


Lys Val Pro Pro Lys Glu Leu Lys Asn Leu Thr Arg Gln Ser Ile Ala 
            580                 585                 590         


Gly Tyr Lys Gln Glu His Gly Glu Tyr Pro Asp Arg Ile Val Ile His 
        595                 600                 605             


Arg Asp Gly Phe Met Arg Glu Asp Leu Asp Gln Val Glu Glu Met Leu 
    610                 615                 620                 


Glu Ser Met Asp Ile Asn Tyr Asp Val Val Glu Ile Arg Lys Gln Ser 
625                 630                 635                 640 


Pro Ala Arg Val Leu Asn Leu Ala Asp Gly Val Ala Lys Ile Pro Asp 
                645                 650                 655     


Lys Gly Ile Ala Ala Leu Asn Arg Glu Glu Asn Arg Ala Ile Leu Ala 
            660                 665                 670         


Thr Phe Gly Asp Pro Glu Ser Gln Ala Thr Ser Ser Asn Thr Gly Leu 
        675                 680                 685             


Pro Gln Pro Ile Gln Val Glu Arg Lys Ala Gly Asp Thr Asp Ile Lys 
    690                 695                 700                 


Thr Leu Thr Ala Gln Val Tyr Leu Leu Ser Gln Ser His Val Gly Ala 
705                 710                 715                 720 


Met Asn Ser Thr Ala Arg Leu Pro Ile Thr Thr Tyr Tyr Ala Asp Arg 
                725                 730                 735     


Ala Ser Glu Ala Ala Ala Glu Gly Tyr Leu Pro Glu Thr Ser Lys Leu 
            740                 745                 750         


Arg Gln Asn Ile Gly Phe Ile 
        755                 


<210>  15

<211>  718
<212>  PRT
<213>  Halorubrum lacusprofundi

<220>
<223>  Ago protein

<400>  15
Met Gln Ala Glu Ile Asp Asp Ala Phe Ala Asp Val Pro Glu Ser Ala 
1               5                   10                  15      


Thr Glu Gln Thr Gly His Ala Leu Thr Thr Phe Arg Ser Glu Lys Ser 
            20                  25                  30          


Leu Ser Glu Phe Ala Val His Glu Tyr Thr Leu Lys Ala Lys Asp Gly 
        35                  40                  45              


Tyr Arg Pro Asp Asp His Gln Ala Ala Leu Arg Asp Thr Tyr Lys Ala 
    50                  55                  60                  


Arg Arg Asp Ile Leu Gly Glu Phe Glu Ser Ser Ser Pro Pro Val Ile 
65                  70                  75                  80  


Ala Val Arg Asp Ala Leu Ala Leu Ala Thr Pro Ser Pro Leu Pro Val 
                85                  90                  95      


Glu Asp Leu Glu Leu Lys Asn Phe Glu Met Val Asn Asp Gly Pro His 
            100                 105                 110         


Thr Leu Asp Tyr Thr Asp Tyr Ser Asp Lys Ala Val Thr Lys Gly Leu 
        115                 120                 125             


Ile Asp Ala Ser Leu Arg Arg Ile Leu Asp Gly Asp Tyr Glu Val Arg 
    130                 135                 140                 


Gly Ile Asp Thr Val Leu Ser Lys Arg Pro Val Ile Gln Lys Gln Asp 
145                 150                 155                 160 


Phe Arg Leu His Glu Arg Trp Asn Leu Ser Leu Ser Val Thr Asn Ala 
                165                 170                 175     


Gly Val Val Tyr Leu Ser Val Asp Phe Arg His Lys Thr Ile Ser Glu 
            180                 185                 190         


Tyr Thr Leu Asp Lys Phe Asp Leu Asp Lys Leu Tyr Arg Gly Leu Arg 
        195                 200                 205             


Val Asn Val Thr Tyr Lys Gln Ser Gly Lys Gly Ala Phe Val Asp Glu 
    210                 215                 220                 


Leu Met Asp Lys Thr Val Asn Glu Ser Ile Asp Asp Met Gly Asn Gln 
225                 230                 235                 240 


Ser Val Val Glu Tyr His Glu Gly Ala Glu Arg Ile Pro Asp Arg Val 
                245                 250                 255     


Leu Lys Glu Ile Ala Arg Ala Asp Arg Arg Val Val Lys Val Thr Lys 
            260                 265                 270         


Gln Gly Ser His Asn Thr Glu Tyr Tyr Pro Gln Arg Leu Leu Ala Leu 
        275                 280                 285             


Gln Gly His Pro Gln Asn Val Lys Ala Phe Ala Pro Arg Phe Asn Glu 
    290                 295                 300                 


Ala Thr Arg Gly Lys Thr Arg Leu Ser Ala Gln Arg Cys Leu Asn Arg 
305                 310                 315                 320 


Ala Thr Thr Phe Val Glu Asn Leu Pro Pro Val Ile Pro Leu Gly Gly 
                325                 330                 335     


Ala Thr Leu Ser Phe Asp Ala Thr Pro Val Asn Gly Asp Asp Thr Trp 
            340                 345                 350         


Glu Met Ser Arg Leu Phe Glu Thr Asp Ala His Ile Leu Gln Phe Ala 
        355                 360                 365             


Glu Glu Gln Thr Gly Asp His Pro Arg Arg Val Lys His Asn Glu Val 
    370                 375                 380                 


Tyr Glu Ala Pro Glu Glu Phe Ser Val Cys Leu Val His Pro Ser Ala 
385                 390                 395                 400 


Gly Pro His Ala Glu Arg Trp Glu Asn Leu Asp Gln Gln Leu Lys Asp 
                405                 410                 415     


Ile Gly Ala Gly Pro Glu Ala Val Asn Arg Val Gln Tyr Asp Pro Phe 
            420                 425                 430         


Lys Thr Ala Asp Glu Ile Tyr Thr Asp Leu Leu Val Asp Val Pro Asp 
        435                 440                 445             


Asp His Glu Tyr Ser Ala Ala Cys Val Ile Leu Pro Lys Ala Asp Phe 
    450                 455                 460                 


Ser Met Gly Glu Ser Ser Ala Ser Asp Ile Tyr His Glu Met Lys Lys 
465                 470                 475                 480 


Ala Leu Arg Gln Arg Arg Val Asp Ser Gln Met Ala His Ile Asp Thr 
                485                 490                 495     


Leu Ala Thr Ser Tyr Ala Leu Pro Asn Val Ala Leu Gly Leu Val Ala 
            500                 505                 510         


Ala Ala Gly Gly Ile Pro Phe Thr Thr Glu Asp Ala Met Pro Gly Glu 
        515                 520                 525             


Thr Asp Leu Phe Ile Gly Ile Asp Val Ser His Arg Tyr Pro Arg Asp 
    530                 535                 540                 


Thr Asp Glu Arg Val His Ile Ala Ala Ser Thr Thr Ser Ile Tyr Gly 
545                 550                 555                 560 


Asp Gly Thr Ile Leu Gly Tyr Thr Ser Ala Lys Pro Gln Thr Gly Glu 
                565                 570                 575     


Lys Val Pro Pro Lys Glu Leu Lys Asn Leu Thr Arg Gln Ser Ile Ala 
            580                 585                 590         


Gly Tyr Lys Gln Glu His Gly Glu Tyr Pro Asp Arg Ile Val Ile His 
        595                 600                 605             


Arg Asp Gly Phe Met Arg Glu Asp Leu Asp Gln Val Glu Glu Met Leu 
    610                 615                 620                 


Glu Ser Met Asp Ile Asn Tyr Asp Val Val Glu Ile Arg Lys Gln Ser 
625                 630                 635                 640 


Pro Ala Arg Val Leu Asn Leu Ala Asp Gly Val Ala Lys Ile Pro Asp 
                645                 650                 655     


Lys Gly Ile Ala Ala Leu Asn Arg Glu Glu Asn Arg Ala Ile Leu Ala 
            660                 665                 670         


Thr Phe Gly Asp Pro Glu Ser Gln Ala Thr Ser Ser Asn Thr Gly Leu 
        675                 680                 685             


Pro Gln Pro Ile Gln Val Glu Arg Lys Ala Gly Asp Thr Asp Ile Lys 
    690                 695                 700                 


Thr Leu Val Val Ser Gln Ser Pro Leu Glu Phe Ser Ser Asn 
705                 710                 715             


<210>  16

<211>  839
<212>  PRT
<213>  Natrialba asiatica

<220>
<223>  Ago protein

<400>  16
Met Lys Thr Gln Asp Asp Ile Ala His Lys Gln Pro Ile Thr Ile Glu 
1               5                   10                  15      


Val Gln Ile Leu Lys Glu Leu Asp Lys Pro Ser Pro Lys Met Ala Thr 
            20                  25                  30          


Arg Phe Leu Val Ala Asp Arg Asp Gly Asn Arg Phe Ser Leu Ala Ile 
        35                  40                  45              


Trp Lys Asn Asn Ala Leu Ser Asp Tyr Asp Trp Thr Ile Gly Gln Trp 
    50                  55                  60                  


Tyr Arg Leu Glu Asn Ala Arg Gly Asn Val Phe Asn Gly Lys Gln Ser 
65                  70                  75                  80  


Leu Asn Gly Ser Ser Lys Met Arg Ala Thr Pro Leu Glu Ala Ser Glu 
                85                  90                  95      


Glu Asp Glu Thr Ser Thr Asp Asp Val Gly Arg Val Asp Thr Ile Leu 
            100                 105                 110         


Gly Asn Met Ser Pro Asp Gln Ala Tyr Leu Ser Leu Phe Pro Ile Ser 
        115                 120                 125             


Arg Ser Phe Asp Thr Leu Ser Val Tyr Glu Tyr Ser Ile Glu Ala Ala 
    130                 135                 140                 


Glu Ala Phe Glu Asp Ala Pro Asp Thr Val Thr Tyr Arg Cys Ala Gly 
145                 150                 155                 160 


Arg Leu Arg Arg Ile Thr Gly Ala Gly Val Ala Tyr Ala Gly Ser Met 
                165                 170                 175     


Arg Ile Val Ser Thr Arg Lys Leu Pro Asp Lys Leu Ala Asp Pro Phe 
            180                 185                 190         


Ser Leu Ser Glu Pro Thr Glu Arg Glu Leu Asn Ala Thr Asp Ala Arg 
        195                 200                 205             


Asp Arg His Arg Ile Glu Arg Leu Leu Lys Ser Leu Val Lys Ala Ala 
    210                 215                 220                 


Ile Asp Asp Ser Thr Tyr Asp Pro Tyr Gln Ile Asn Arg Ile Arg Ala 
225                 230                 235                 240 


Arg Thr Pro Ser Ile Thr Ala Gly Asp Gly Leu Phe Glu Ala Cys Tyr 
                245                 250                 255     


Glu Phe Ala Ala Arg Val Asp Val Met Pro Ser Gly Asp Ala Phe Val 
            260                 265                 270         


Gly Ile Glu Val Arg Tyr His Thr Arg Ser Gln Val Thr Ala Asp Val 
        275                 280                 285             


Tyr Glu Asp Lys Thr Ala Glu Leu Val Gly Thr Ile Val Glu His Asp 
    290                 295                 300                 


Pro Glu Arg Tyr Asn Ile Ser Gly Thr Gly Arg Val Val Gly Phe Thr 
305                 310                 315                 320 


Asp His His Phe Thr Asp Ala Leu Asp Glu Leu Gly Gly Leu Ser Leu 
                325                 330                 335     


Ala Asp Trp Tyr Ala Gln Lys Asp Arg Val Pro Glu Gly Val Leu Glu 
            340                 345                 350         


Ala Leu Arg Glu Lys Asn Pro Arg Leu Val Asp Ile Gln Tyr Gln Glu 
        355                 360                 365             


Asp Glu Pro Ala Arg Ile His Val Pro Asp Leu Leu Arg Val Ala Pro 
    370                 375                 380                 


Arg Lys Glu Val Val Lys Glu Leu Asp Pro Ala Phe His Arg Arg Trp 
385                 390                 395                 400 


Asp Arg Glu Ala Lys Met Leu Pro Asp Lys Arg Phe Arg His Ala Ile 
                405                 410                 415     


Glu Phe Val Asp His Leu Gly Ser Leu Pro Asp Ile Asp Ala Thr Val 
            420                 425                 430         


Ala Pro Glu Pro Leu Gly Pro Ser Leu Ser Tyr Met Ser Thr Ala Val 
        435                 440                 445             


Asp Arg Glu Lys Asn Leu Arg Phe Lys Asp Gly Arg Thr Ala Thr Thr 
    450                 455                 460                 


Pro Ser Ser Gly Ile Arg Ser Gly Val Tyr Gln Gln Pro Thr Ser Phe 
465                 470                 475                 480 


Asp Ile Ala Tyr Val Tyr Pro Thr Glu Ser Glu Gln Glu Ser Lys Gln 
                485                 490                 495     


Phe Ile Ser Asn Phe Glu Asn Lys Leu Ser Gln Cys Gln Cys Glu Pro 
            500                 505                 510         


Thr Ala Ala Arg His Val Pro Tyr Glu Leu Gly Gly Glu Leu Ser Tyr 
        515                 520                 525             


Leu Ala Val Ile Asn Glu Leu Glu Ser Val Asp Ala Val Leu Ala Val 
    530                 535                 540                 


Val Pro Pro Arg Asp Asp Asp Arg Ile Thr Ala Gly Asp Ile Thr Asp 
545                 550                 555                 560 


Pro Tyr Pro Glu Phe Lys Lys Gly Leu Gly Lys Gln Lys Ile Pro Ser 
                565                 570                 575     


Gln Met Ile Val Thr Glu Asn Leu Gly Thr Arg Trp Val Met Asn Asn 
            580                 585                 590         


Thr Ala Met Gly Leu Ile Ala Gly Ala Gly Gly Val Pro Trp Arg Val 
        595                 600                 605             


Asp Glu Met Pro Gly Glu Ala Asp Cys Phe Ile Gly Leu Asp Val Thr 
    610                 615                 620                 


Arg Asp Pro Glu Thr Gly Gln His Leu Gly Ala Ser Ala Asn Val Val 
625                 630                 635                 640 


Tyr Ala Asp Gly Thr Val Phe Ala Ser Lys Thr Gln Thr Leu Gln Ser 
                645                 650                 655     


Gly Glu Thr Phe Asp Glu Gln Ser Ile Ile Asp Val Ile Lys Asp Val 
            660                 665                 670         


Phe Gln Glu Phe Val Arg Arg Glu Gly Arg Ser Pro Glu His Ile Val 
        675                 680                 685             


Ile His Arg Asp Gly Arg Leu Phe Glu Asp Ala Asp Glu Ile Gln Ala 
    690                 695                 700                 


Pro Phe Ala Asp Ser Gly Val Ser Ile Asp Ile Leu Asp Ile Arg Lys 
705                 710                 715                 720 


Ser Gly Ala Pro Arg Ile Ala Gln Tyr Glu Asp Asn Ser Phe Lys Ile 
                725                 730                 735     


Asp Glu Lys Gly Arg Leu Phe Ile Ser Gln Asp Asp Thr His Gly Phe 
            740                 745                 750         


Ile Ala Thr Thr Gly Lys Pro Glu Phe Asp Asp Ser Asp Asn Leu Gly 
        755                 760                 765             


Thr Pro Lys Thr Leu Arg Val Val Arg Arg Ala Gly Asp Thr Pro Met 
    770                 775                 780                 


Leu Thr Leu Leu Lys Gln Val Tyr Trp Leu Ser Glu Ala His Val Gly 
785                 790                 795                 800 


Ser Val Ser Arg Ser Val Arg Leu Pro Ile Thr Thr Tyr Tyr Ala Asp 
                805                 810                 815     


Arg Cys Ala Glu His Ala Arg Glu Gly Tyr Leu Leu His Gly Glu Leu 
            820                 825                 830         


Ile Glu Gly Val Pro Tyr Leu 
        835                 


<210>  17

<211>  870
<212>  PRT
<213>  Artificial

<220>
<223>  Plasmid JVGE_Synechococcus_sp_2A_BFP

<400>  17
Met Gly Ile Cys Trp Gln Lys Thr Glu Ala Asp Ile Arg Ser Asp Val 
1               5                   10                  15      


Ser Gly Trp Glu Ile Tyr Arg Gly Phe Lys Leu Asp Ile Phe Val Ser 
            20                  25                  30          


Ser Gln Gly Asn Val Phe Leu Glu Val Asp Glu His Tyr Lys Leu Phe 
        35                  40                  45              


Ser Ala Trp Thr Leu Thr Gln Trp Leu Glu Trp Tyr Pro Asp Phe Ser 
    50                  55                  60                  


Ala Lys Ile Leu Arg Asn Thr Tyr Asp Gly Arg Thr Trp Lys Leu Gln 
65                  70                  75                  80  


Lys Ile Thr Asn Glu Asp Pro Asn Asn Ile Asp Ser Gly Thr Gly Gln 
                85                  90                  95      


Thr Leu Ala Thr Tyr His Lys Asn His Gln Lys Pro Ala Thr Asp Gln 
            100                 105                 110         


Glu Ile Asn Ser Ser Lys Val Ile Tyr Val Lys Pro Tyr Asn Ser Lys 
        115                 120                 125             


Lys Glu Glu Ser Tyr Pro His Leu Ser Ser Arg Val Lys Pro Cys Leu 
    130                 135                 140                 


Phe Leu Asp Thr Leu Ser Glu Leu Ala Ser Gln Gly Asp Arg Lys Val 
145                 150                 155                 160 


Lys Glu Val Phe Asn Leu Ile Lys Pro Ser Ile Glu Asp Arg Phe Ser 
                165                 170                 175     


Arg Ala Thr Glu Ile Ala Lys Gln Leu Ala Val Glu Ile Tyr Asn Ile 
            180                 185                 190         


Asp Glu Glu Ile Ser Asp Asp Ile Lys Val Val Gln Val Gln Ala Gln 
        195                 200                 205             


Gln Ser Ser Gln Asp Lys Ser Ile Leu Leu Ala His Ser Ser Lys Arg 
    210                 215                 220                 


Ile Asp Lys Val Phe Lys Ser Leu Asp Gln Gly Cys Phe Arg Val Gly 
225                 230                 235                 240 


Glu Ile Lys Phe Gly Cys Ile Asn Leu Leu Asp Lys Asn Gln Asp Gly 
                245                 250                 255     


Trp Ser Lys Phe Ile Leu Gln Lys Leu Gln Lys Leu Ala Thr Ile His 
            260                 265                 270         


Asn Ile Asn Ile Asp Ala Asn Leu Val Lys Ala Ala Val Asp Ile Pro 
        275                 280                 285             


Glu Lys Asp Phe Glu Ile Asp Gln Phe Trp Glu Ser Trp Val Glu Gln 
    290                 295                 300                 


Asp Ile Lys Thr Ile Leu Val Ile Ser Glu Trp Leu Asp Asn Lys Tyr 
305                 310                 315                 320 


Lys Thr Lys Leu Thr Arg Asp Ala Leu Glu His Gly Ile Thr Leu Gln 
                325                 330                 335     


Phe Met Leu Pro Leu Lys Glu Asn Val Arg Arg Ile Glu Ser Asn Lys 
            340                 345                 350         


Gly Val Glu Ser Lys Ile Thr Cys Phe Thr Ser Asp Gln Tyr Arg Ala 
        355                 360                 365             


Asn Asn Ile Leu Leu Gly Leu Leu Ala Lys Ala Gly Trp Gln Ala Val 
    370                 375                 380                 


Gly Leu Pro Leu Leu Asn Asn Glu Tyr Ala Ala Asp Leu Val Ile Gly 
385                 390                 395                 400 


Phe Asp Ala Gly Arg Asn Glu Thr Leu Ser Tyr Gly Thr Ser Ser Phe 
                405                 410                 415     


Ala Val Leu Ala Asp Gly Gln Ile Leu Gly Trp Glu Leu Pro Glu Ala 
            420                 425                 430         


Gln Lys Gly Glu Ile Leu Asp Pro Asp His Val Arg Arg Thr Val Arg 
        435                 440                 445             


Arg Ile Ile Ser Gln Phe Gln Lys Met Asn Gly Lys Gln Ser Pro Lys 
    450                 455                 460                 


Arg Ile Leu Leu Met Arg Asp Gly Leu Ile Gln Gln Gln Glu Phe Ser 
465                 470                 475                 480 


Leu Ile Thr Glu Ala Leu Glu Glu Gly Glu Ile Lys Tyr Asp Leu Ile 
                485                 490                 495     


Ser Val Arg Lys Ser Gly Ala Gly Arg Ile Gly Arg Arg Asn Ser Asp 
            500                 505                 510         


Gly Thr Tyr Val Asp Ala Pro Lys Gly Thr Val Ile Phe Ser Gly Asn 
        515                 520                 525             


Asp Lys Phe Lys Ile Val Thr Ser Glu Ala Lys Ala Gly Gly Ser Ala 
    530                 535                 540                 


Arg Pro Leu Phe Val Val Arg Glu Gln Gly Asp Thr Pro Ile Glu Ile 
545                 550                 555                 560 


Ile Ala Glu Gln Phe Tyr Arg Leu Thr Gln Leu His Pro Val Ser Gly 
                565                 570                 575     


Ser Phe Thr Ser Arg Leu Pro Met Pro Leu Asn Tyr Ala Asp Lys Leu 
            580                 585                 590         


Ala Lys Lys Ile Gln Ser Leu Gly Ser Val Gly Ile Leu Gln Asn Leu 
        595                 600                 605             


Asp Arg Lys Lys Leu Phe Phe Val Gly Ser Glu Gly Arg Gly Ser Leu 
    610                 615                 620                 


Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Ser Gly Ser Glu 
625                 630                 635                 640 


Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met Glu Gly Thr Val 
                645                 650                 655     


Asp Asn His His Phe Lys Cys Thr Ser Glu Gly Glu Gly Lys Pro Tyr 
            660                 665                 670         


Glu Gly Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly Gly Pro Leu 
        675                 680                 685             


Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr Gly Ser Lys 
    690                 695                 700                 


Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe Lys Gln Ser 
705                 710                 715                 720 


Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr Glu Asp Gly 
                725                 730                 735     


Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp Gly Cys Leu 
            740                 745                 750         


Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser Asn Gly Pro 
        755                 760                 765             


Val Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr Glu Thr Leu 
    770                 775                 780                 


Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met Ala Leu Lys 
785                 790                 795                 800 


Leu Val Gly Gly Ser His Leu Ile Ala Asn Ile Lys Thr Thr Tyr Arg 
                805                 810                 815     


Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val Tyr Tyr Val 
            820                 825                 830         


Asp Tyr Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu Thr Tyr Val 
        835                 840                 845             


Glu Gln His Glu Val Ala Val Ala Arg Tyr Cys Asp Leu Pro Ser Lys 
    850                 855                 860                 


Leu Gly His Lys Leu Asn 
865                 870 


<210>  18

<211>  1142
<212>  PRT
<213>  Artificial

<220>
<223>  Plasmid JVGE_Natronobacterium_gre_2A_BFP

<400>  18
Met Gly Thr Val Ile Asp Leu Asp Ser Thr Thr Thr Ala Asp Glu Leu 
1               5                   10                  15      


Thr Ser Gly His Thr Tyr Asp Ile Ser Val Thr Leu Thr Gly Val Tyr 
            20                  25                  30          


Asp Asn Thr Asp Glu Gln His Pro Arg Met Ser Leu Ala Phe Glu Gln 
        35                  40                  45              


Asp Asn Gly Glu Arg Arg Tyr Ile Thr Leu Trp Lys Asn Thr Thr Pro 
    50                  55                  60                  


Lys Asp Val Phe Thr Tyr Asp Tyr Ala Thr Gly Ser Thr Tyr Ile Phe 
65                  70                  75                  80  


Thr Asn Ile Asp Tyr Glu Val Lys Asp Gly Tyr Glu Asn Leu Thr Ala 
                85                  90                  95      


Thr Tyr Gln Thr Thr Val Glu Asn Ala Thr Ala Gln Glu Val Gly Thr 
            100                 105                 110         


Thr Asp Glu Asp Glu Thr Phe Ala Gly Gly Glu Pro Leu Asp His His 
        115                 120                 125             


Leu Asp Asp Ala Leu Asn Glu Thr Pro Asp Asp Ala Glu Thr Glu Ser 
    130                 135                 140                 


Asp Ser Gly His Val Met Thr Ser Phe Ala Ser Arg Asp Gln Leu Pro 
145                 150                 155                 160 


Glu Trp Thr Leu His Thr Tyr Thr Leu Thr Ala Thr Asp Gly Ala Lys 
                165                 170                 175     


Thr Asp Thr Glu Tyr Ala Arg Arg Thr Leu Ala Tyr Thr Val Arg Gln 
            180                 185                 190         


Glu Leu Tyr Thr Asp His Asp Ala Ala Pro Val Ala Thr Asp Gly Leu 
        195                 200                 205             


Met Leu Leu Thr Pro Glu Pro Leu Gly Glu Thr Pro Leu Asp Leu Asp 
    210                 215                 220                 


Cys Gly Val Arg Val Glu Ala Asp Glu Thr Arg Thr Leu Asp Tyr Thr 
225                 230                 235                 240 


Thr Ala Lys Asp Arg Leu Leu Ala Arg Glu Leu Val Glu Glu Gly Leu 
                245                 250                 255     


Lys Arg Ser Leu Trp Asp Asp Tyr Leu Val Arg Gly Ile Asp Glu Val 
            260                 265                 270         


Leu Ser Lys Glu Pro Val Leu Thr Cys Asp Glu Phe Asp Leu His Glu 
        275                 280                 285             


Arg Tyr Asp Leu Ser Val Glu Val Gly His Ser Gly Arg Ala Tyr Leu 
    290                 295                 300                 


His Ile Asn Phe Arg His Arg Phe Val Pro Lys Leu Thr Leu Ala Asp 
305                 310                 315                 320 


Ile Asp Asp Asp Asn Ile Tyr Pro Gly Leu Arg Val Lys Thr Thr Tyr 
                325                 330                 335     


Arg Pro Arg Arg Gly His Ile Val Trp Gly Leu Arg Asp Glu Cys Ala 
            340                 345                 350         


Thr Asp Ser Leu Asn Thr Leu Gly Asn Gln Ser Val Val Ala Tyr His 
        355                 360                 365             


Arg Asn Asn Gln Thr Pro Ile Asn Thr Asp Leu Leu Asp Ala Ile Glu 
    370                 375                 380                 


Ala Ala Asp Arg Arg Val Val Glu Thr Arg Arg Gln Gly His Gly Asp 
385                 390                 395                 400 


Asp Ala Val Ser Phe Pro Gln Glu Leu Leu Ala Val Glu Pro Asn Thr 
                405                 410                 415     


His Gln Ile Lys Gln Phe Ala Ser Asp Gly Phe His Gln Gln Ala Arg 
            420                 425                 430         


Ser Lys Thr Arg Leu Ser Ala Ser Arg Cys Ser Glu Lys Ala Gln Ala 
        435                 440                 445             


Phe Ala Glu Arg Leu Asp Pro Val Arg Leu Asn Gly Ser Thr Val Glu 
    450                 455                 460                 


Phe Ser Ser Glu Phe Phe Thr Gly Asn Asn Glu Gln Gln Leu Arg Leu 
465                 470                 475                 480 


Leu Tyr Glu Asn Gly Glu Ser Val Leu Thr Phe Arg Asp Gly Ala Arg 
                485                 490                 495     


Gly Ala His Pro Asp Glu Thr Phe Ser Lys Gly Ile Val Asn Pro Pro 
            500                 505                 510         


Glu Ser Phe Glu Val Ala Val Val Leu Pro Glu Gln Gln Ala Asp Thr 
        515                 520                 525             


Cys Lys Ala Gln Trp Asp Thr Met Ala Asp Leu Leu Asn Gln Ala Gly 
    530                 535                 540                 


Ala Pro Pro Thr Arg Ser Glu Thr Val Gln Tyr Asp Ala Phe Ser Ser 
545                 550                 555                 560 


Pro Glu Ser Ile Ser Leu Asn Val Ala Gly Ala Ile Asp Pro Ser Glu 
                565                 570                 575     


Val Asp Ala Ala Phe Val Val Leu Pro Pro Asp Gln Glu Gly Phe Ala 
            580                 585                 590         


Asp Leu Ala Ser Pro Thr Glu Thr Tyr Asp Glu Leu Lys Lys Ala Leu 
        595                 600                 605             


Ala Asn Met Gly Ile Tyr Ser Gln Met Ala Tyr Phe Asp Arg Phe Arg 
    610                 615                 620                 


Asp Ala Lys Ile Phe Tyr Thr Arg Asn Val Ala Leu Gly Leu Leu Ala 
625                 630                 635                 640 


Ala Ala Gly Gly Val Ala Phe Thr Thr Glu His Ala Met Pro Gly Asp 
                645                 650                 655     


Ala Asp Met Phe Ile Gly Ile Asp Val Ser Arg Ser Tyr Pro Glu Asp 
            660                 665                 670         


Gly Ala Ser Gly Gln Ile Asn Ile Ala Ala Thr Ala Thr Ala Val Tyr 
        675                 680                 685             


Lys Asp Gly Thr Ile Leu Gly His Ser Ser Thr Arg Pro Gln Leu Gly 
    690                 695                 700                 


Glu Lys Leu Gln Ser Thr Asp Val Arg Asp Ile Met Lys Asn Ala Ile 
705                 710                 715                 720 


Leu Gly Tyr Gln Gln Val Thr Gly Glu Ser Pro Thr His Ile Val Ile 
                725                 730                 735     


His Arg Asp Gly Phe Met Asn Glu Asp Leu Asp Pro Ala Thr Glu Phe 
            740                 745                 750         


Leu Asn Glu Gln Gly Val Glu Tyr Asp Ile Val Glu Ile Arg Lys Gln 
        755                 760                 765             


Pro Gln Thr Arg Leu Leu Ala Val Ser Asp Val Gln Tyr Asp Thr Pro 
    770                 775                 780                 


Val Lys Ser Ile Ala Ala Ile Asn Gln Asn Glu Pro Arg Ala Thr Val 
785                 790                 795                 800 


Ala Thr Phe Gly Ala Pro Glu Tyr Leu Ala Thr Arg Asp Gly Gly Gly 
                805                 810                 815     


Leu Pro Arg Pro Ile Gln Ile Glu Arg Val Ala Gly Glu Thr Asp Ile 
            820                 825                 830         


Glu Thr Leu Thr Arg Gln Val Tyr Leu Leu Ser Gln Ser His Ile Gln 
        835                 840                 845             


Val His Asn Ser Thr Ala Arg Leu Pro Ile Thr Thr Ala Tyr Ala Asp 
    850                 855                 860                 


Gln Ala Ser Thr His Ala Thr Lys Gly Tyr Leu Val Gln Thr Gly Ala 
865                 870                 875                 880 


Phe Glu Ser Asn Val Gly Phe Leu Gly Ser Glu Gly Arg Gly Ser Leu 
                885                 890                 895     


Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Ser Gly Ser Glu 
            900                 905                 910         


Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met Glu Gly Thr Val 
        915                 920                 925             


Asp Asn His His Phe Lys Cys Thr Ser Glu Gly Glu Gly Lys Pro Tyr 
    930                 935                 940                 


Glu Gly Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly Gly Pro Leu 
945                 950                 955                 960 


Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr Gly Ser Lys 
                965                 970                 975     


Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe Lys Gln Ser 
            980                 985                 990         


Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr Glu Asp Gly 
        995                 1000                1005            


Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp Gly Cys Leu 
    1010                1015                1020                


Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser Asn Gly Pro 
1025                1030                1035                1040


Val Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr Glu Thr Leu 
                1045                1050                1055    


Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met Ala Leu Lys 
            1060                1065                1070        


Leu Val Gly Gly Ser His Leu Ile Ala Asn Ile Lys Thr Thr Tyr Arg 
        1075                1080                1085            


Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val Tyr Tyr Val 
    1090                1095                1100                


Asp Tyr Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu Thr Tyr Val 
1105                1110                1115                1120


Glu Gln His Glu Val Ala Val Ala Arg Tyr Cys Asp Leu Pro Ser Lys 
                1125                1130                1135    


Leu Gly His Lys Leu Asn 
            1140        


<210>  19

<211>  1014
<212>  PRT
<213>  Artificial

<220>
<223>  Plasmid JVGE_Halobacterium_2A_BFP

<400>  19
Met Gly Gln Ala Glu Ile Asp Asp Ala Phe Ala Asp Val Pro Glu Ser 
1               5                   10                  15      


Ala Thr Glu Gln Thr Gly His Ala Leu Thr Thr Phe Arg Ser Glu Lys 
            20                  25                  30          


Ser Leu Ser Glu Phe Ala Val His Glu Tyr Thr Leu Lys Ala Lys Asp 
        35                  40                  45              


Gly Tyr Arg Pro Asp Asp His Gln Ala Ala Leu Arg Asp Thr Tyr Lys 
    50                  55                  60                  


Ala Arg Arg Asp Ile Leu Gly Glu Phe Glu Ser Ser Ser Pro Pro Val 
65                  70                  75                  80  


Ile Ala Val Arg Asp Ala Leu Ala Leu Ala Thr Pro Ser Pro Leu Pro 
                85                  90                  95      


Val Glu Asp Leu Glu Leu Lys Asn Phe Glu Met Val Asn Asp Gly Pro 
            100                 105                 110         


His Thr Leu Asp Tyr Thr Asp Tyr Ser Asp Lys Ala Val Thr Lys Gly 
        115                 120                 125             


Leu Ile Asp Ala Ser Leu Arg Arg Ile Leu Asp Gly Asp Tyr Glu Val 
    130                 135                 140                 


Arg Gly Ile Asp Thr Val Leu Ser Lys Arg Pro Val Ile Gln Lys Gln 
145                 150                 155                 160 


Asp Phe Arg Leu His Glu Arg Trp Asn Leu Ser Leu Ser Val Thr Asn 
                165                 170                 175     


Ala Gly Val Val Tyr Leu Ser Val Asp Phe Arg His Lys Thr Ile Ser 
            180                 185                 190         


Glu Tyr Thr Leu Asp Lys Phe Asp Leu Asp Lys Leu Tyr Arg Gly Leu 
        195                 200                 205             


Arg Val Asn Val Thr Tyr Lys Gln Ser Gly Lys Gly Ala Phe Val Asp 
    210                 215                 220                 


Glu Leu Met Asp Lys Thr Val Asn Glu Ser Ile Asp Asp Met Gly Asn 
225                 230                 235                 240 


Gln Ser Val Val Glu Tyr His Glu Gly Ala Glu Arg Ile Pro Asp Arg 
                245                 250                 255     


Val Leu Lys Glu Ile Ala Arg Ala Asp Arg Arg Val Val Lys Val Thr 
            260                 265                 270         


Lys Gln Gly Ser His Asn Thr Glu Tyr Tyr Pro Gln Arg Leu Leu Ala 
        275                 280                 285             


Leu Gln Gly His Pro Gln Asn Val Lys Ala Phe Ala Pro Arg Phe Asn 
    290                 295                 300                 


Glu Ala Thr Arg Gly Lys Thr Arg Leu Ser Ala Gln Arg Cys Leu Asn 
305                 310                 315                 320 


Arg Ala Thr Thr Phe Val Glu Asn Leu Pro Pro Val Ile Pro Leu Gly 
                325                 330                 335     


Gly Ala Thr Leu Ser Phe Asp Ala Thr Pro Val Asn Gly Asp Asp Thr 
            340                 345                 350         


Trp Glu Met Ser Arg Leu Phe Glu Thr Asp Ala His Ile Leu Gln Phe 
        355                 360                 365             


Ala Glu Glu Gln Thr Gly Asp His Pro Arg Arg Val Lys His Asn Glu 
    370                 375                 380                 


Val Tyr Glu Ala Pro Glu Glu Phe Ser Val Cys Leu Val His Pro Ser 
385                 390                 395                 400 


Ala Gly Pro His Ala Glu Arg Trp Glu Asn Leu Asp Gln Gln Leu Lys 
                405                 410                 415     


Asp Ile Gly Ala Gly Pro Glu Ala Val Asn Arg Val Gln Tyr Asp Pro 
            420                 425                 430         


Phe Lys Thr Ala Asp Glu Ile Tyr Thr Asp Leu Leu Val Asp Val Pro 
        435                 440                 445             


Asp Asp His Glu Tyr Ser Ala Ala Cys Val Ile Leu Pro Lys Ala Asp 
    450                 455                 460                 


Phe Ser Met Gly Glu Ser Ser Ala Ser Asp Ile Tyr His Glu Met Lys 
465                 470                 475                 480 


Lys Ala Leu Arg Gln Arg Arg Val Asp Ser Gln Met Ala His Ile Asp 
                485                 490                 495     


Thr Leu Ala Thr Ser Tyr Ala Leu Pro Asn Val Ala Leu Gly Leu Val 
            500                 505                 510         


Ala Ala Ala Gly Gly Ile Pro Phe Thr Thr Glu Asp Ala Met Pro Gly 
        515                 520                 525             


Glu Thr Asp Leu Phe Ile Gly Ile Asp Val Ser His Arg Tyr Pro Arg 
    530                 535                 540                 


Asp Thr Asp Glu Arg Val His Ile Ala Ala Ser Thr Thr Ser Ile Tyr 
545                 550                 555                 560 


Gly Asp Gly Thr Ile Leu Gly Tyr Thr Ser Ala Lys Pro Gln Thr Gly 
                565                 570                 575     


Glu Lys Val Pro Pro Lys Glu Leu Lys Asn Leu Thr Arg Gln Ser Ile 
            580                 585                 590         


Ala Gly Tyr Lys Gln Glu His Gly Glu Tyr Pro Asp Arg Ile Val Ile 
        595                 600                 605             


His Arg Asp Gly Phe Met Arg Glu Asp Leu Asp Gln Val Glu Glu Met 
    610                 615                 620                 


Leu Glu Ser Met Asp Ile Asn Tyr Asp Val Val Glu Ile Arg Lys Gln 
625                 630                 635                 640 


Ser Pro Ala Arg Val Leu Asn Leu Ala Asp Gly Val Ala Lys Ile Pro 
                645                 650                 655     


Asp Lys Gly Ile Ala Ala Leu Asn Arg Glu Glu Asn Arg Ala Ile Leu 
            660                 665                 670         


Ala Thr Phe Gly Asp Pro Glu Ser Gln Ala Thr Ser Ser Asn Thr Gly 
        675                 680                 685             


Leu Pro Gln Pro Ile Gln Val Glu Arg Lys Ala Gly Asp Thr Asp Ile 
    690                 695                 700                 


Lys Thr Leu Thr Ala Gln Val Tyr Leu Leu Ser Gln Ser His Val Gly 
705                 710                 715                 720 


Ala Met Asn Ser Thr Ala Arg Leu Pro Ile Thr Thr Tyr Tyr Ala Asp 
                725                 730                 735     


Arg Ala Ser Glu Ala Ala Ala Glu Gly Tyr Leu Pro Glu Thr Ser Lys 
            740                 745                 750         


Leu Arg Gln Asn Ile Gly Phe Ile Gly Ser Glu Gly Arg Gly Ser Leu 
        755                 760                 765             


Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Ser Gly Ser Glu 
    770                 775                 780                 


Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met Glu Gly Thr Val 
785                 790                 795                 800 


Asp Asn His His Phe Lys Cys Thr Ser Glu Gly Glu Gly Lys Pro Tyr 
                805                 810                 815     


Glu Gly Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly Gly Pro Leu 
            820                 825                 830         


Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr Gly Ser Lys 
        835                 840                 845             


Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe Lys Gln Ser 
    850                 855                 860                 


Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr Glu Asp Gly 
865                 870                 875                 880 


Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp Gly Cys Leu 
                885                 890                 895     


Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser Asn Gly Pro 
            900                 905                 910         


Val Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr Glu Thr Leu 
        915                 920                 925             


Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met Ala Leu Lys 
    930                 935                 940                 


Leu Val Gly Gly Ser His Leu Ile Ala Asn Ile Lys Thr Thr Tyr Arg 
945                 950                 955                 960 


Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val Tyr Tyr Val 
                965                 970                 975     


Asp Tyr Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu Thr Tyr Val 
            980                 985                 990         


Glu Gln His Glu Val Ala Val Ala Arg Tyr Cys Asp Leu Pro Ser Lys 
        995                 1000                1005            


Leu Gly His Lys Leu Asn 
    1010                


<210>  20

<211>  1094
<212>  PRT
<213>  Artificial

<220>
<223>  Plasmid JVGE_Natrialba asiatica_2A_BFP

<400>  20
Met Gly Lys Thr Gln Asp Asp Ile Ala His Lys Gln Pro Ile Thr Ile 
1               5                   10                  15      


Glu Val Gln Ile Leu Lys Glu Leu Asp Lys Pro Ser Pro Lys Met Ala 
            20                  25                  30          


Thr Arg Phe Leu Val Ala Asp Arg Asp Gly Asn Arg Phe Ser Leu Ala 
        35                  40                  45              


Ile Trp Lys Asn Asn Ala Leu Ser Asp Tyr Asp Trp Thr Ile Gly Gln 
    50                  55                  60                  


Trp Tyr Arg Leu Glu Asn Ala Arg Gly Asn Val Phe Asn Gly Lys Gln 
65                  70                  75                  80  


Ser Leu Asn Gly Ser Ser Lys Met Arg Ala Thr Pro Leu Glu Ala Ser 
                85                  90                  95      


Glu Glu Asp Glu Thr Ser Thr Asp Asp Val Gly Arg Val Asp Thr Ile 
            100                 105                 110         


Leu Gly Asn Met Ser Pro Asp Gln Ala Tyr Leu Ser Leu Phe Pro Ile 
        115                 120                 125             


Ser Arg Ser Phe Asp Thr Leu Ser Val Tyr Glu Tyr Ser Ile Glu Ala 
    130                 135                 140                 


Ala Glu Ala Phe Glu Asp Ala Pro Asp Thr Val Thr Tyr Arg Cys Ala 
145                 150                 155                 160 


Gly Arg Leu Arg Arg Ile Thr Gly Ala Gly Val Ala Tyr Ala Gly Ser 
                165                 170                 175     


Met Arg Ile Val Ser Thr Arg Lys Leu Pro Asp Lys Leu Ala Asp Pro 
            180                 185                 190         


Phe Ser Leu Ser Glu Pro Thr Glu Arg Glu Leu Asn Ala Thr Asp Ala 
        195                 200                 205             


Arg Asp Arg His Arg Ile Glu Arg Leu Leu Lys Ser Leu Val Lys Ala 
    210                 215                 220                 


Ala Ile Asp Asp Ser Thr Tyr Asp Pro Tyr Gln Ile Asn Arg Ile Arg 
225                 230                 235                 240 


Ala Arg Thr Pro Ser Ile Thr Ala Gly Asp Gly Leu Phe Glu Ala Cys 
                245                 250                 255     


Tyr Glu Phe Ala Ala Arg Val Asp Val Met Pro Ser Gly Asp Ala Phe 
            260                 265                 270         


Val Gly Ile Glu Val Arg Tyr His Thr Arg Ser Gln Val Thr Ala Asp 
        275                 280                 285             


Val Tyr Glu Asp Lys Thr Ala Glu Leu Val Gly Thr Ile Val Glu His 
    290                 295                 300                 


Asp Pro Glu Arg Tyr Asn Ile Ser Gly Thr Gly Arg Val Val Gly Phe 
305                 310                 315                 320 


Thr Asp His His Phe Thr Asp Ala Leu Asp Glu Leu Gly Gly Leu Ser 
                325                 330                 335     


Leu Ala Asp Trp Tyr Ala Gln Lys Asp Arg Val Pro Glu Gly Val Leu 
            340                 345                 350         


Glu Ala Leu Arg Glu Lys Asn Pro Arg Leu Val Asp Ile Gln Tyr Gln 
        355                 360                 365             


Glu Asp Glu Pro Ala Arg Ile His Val Pro Asp Leu Leu Arg Val Ala 
    370                 375                 380                 


Pro Arg Lys Glu Val Val Lys Glu Leu Asp Pro Ala Phe His Arg Arg 
385                 390                 395                 400 


Trp Asp Arg Glu Ala Lys Met Leu Pro Asp Lys Arg Phe Arg His Ala 
                405                 410                 415     


Ile Glu Phe Val Asp His Leu Gly Ser Leu Pro Asp Ile Asp Ala Thr 
            420                 425                 430         


Val Ala Pro Glu Pro Leu Gly Pro Ser Leu Ser Tyr Met Ser Thr Ala 
        435                 440                 445             


Val Asp Arg Glu Lys Asn Leu Arg Phe Lys Asp Gly Arg Thr Ala Thr 
    450                 455                 460                 


Thr Pro Ser Ser Gly Ile Arg Ser Gly Val Tyr Gln Gln Pro Thr Ser 
465                 470                 475                 480 


Phe Asp Ile Ala Tyr Val Tyr Pro Thr Glu Ser Glu Gln Glu Ser Lys 
                485                 490                 495     


Gln Phe Ile Ser Asn Phe Glu Asn Lys Leu Ser Gln Cys Gln Cys Glu 
            500                 505                 510         


Pro Thr Ala Ala Arg His Val Pro Tyr Glu Leu Gly Gly Glu Leu Ser 
        515                 520                 525             


Tyr Leu Ala Val Ile Asn Glu Leu Glu Ser Val Asp Ala Val Leu Ala 
    530                 535                 540                 


Val Val Pro Pro Arg Asp Asp Asp Arg Ile Thr Ala Gly Asp Ile Thr 
545                 550                 555                 560 


Asp Pro Tyr Pro Glu Phe Lys Lys Gly Leu Gly Lys Gln Lys Ile Pro 
                565                 570                 575     


Ser Gln Met Ile Val Thr Glu Asn Leu Gly Thr Arg Trp Val Met Asn 
            580                 585                 590         


Asn Thr Ala Met Gly Leu Ile Ala Gly Ala Gly Gly Val Pro Trp Arg 
        595                 600                 605             


Val Asp Glu Met Pro Gly Glu Ala Asp Cys Phe Ile Gly Leu Asp Val 
    610                 615                 620                 


Thr Arg Asp Pro Glu Thr Gly Gln His Leu Gly Ala Ser Ala Asn Val 
625                 630                 635                 640 


Val Tyr Ala Asp Gly Thr Val Phe Ala Ser Lys Thr Gln Thr Leu Gln 
                645                 650                 655     


Ser Gly Glu Thr Phe Asp Glu Gln Ser Ile Ile Asp Val Ile Lys Asp 
            660                 665                 670         


Val Phe Gln Glu Phe Val Arg Arg Glu Gly Arg Ser Pro Glu His Ile 
        675                 680                 685             


Val Ile His Arg Asp Gly Arg Leu Phe Glu Asp Ala Asp Glu Ile Gln 
    690                 695                 700                 


Ala Pro Phe Ala Asp Ser Gly Val Ser Ile Asp Ile Leu Asp Ile Arg 
705                 710                 715                 720 


Lys Ser Gly Ala Pro Arg Ile Ala Gln Tyr Glu Asp Asn Ser Phe Lys 
                725                 730                 735     


Ile Asp Glu Lys Gly Arg Leu Phe Ile Ser Gln Asp Asp Thr His Gly 
            740                 745                 750         


Phe Ile Ala Thr Thr Gly Lys Pro Glu Phe Asp Asp Ser Asp Asn Leu 
        755                 760                 765             


Gly Thr Pro Lys Thr Leu Arg Val Val Arg Arg Ala Gly Asp Thr Pro 
    770                 775                 780                 


Met Leu Thr Leu Leu Lys Gln Val Tyr Trp Leu Ser Glu Ala His Val 
785                 790                 795                 800 


Gly Ser Val Ser Arg Ser Val Arg Leu Pro Ile Thr Thr Tyr Tyr Ala 
                805                 810                 815     


Asp Arg Cys Ala Glu His Ala Arg Glu Gly Tyr Leu Leu His Gly Glu 
            820                 825                 830         


Leu Ile Glu Gly Val Pro Tyr Leu Gly Ser Glu Gly Arg Gly Ser Leu 
        835                 840                 845             


Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Ser Gly Ser Glu 
    850                 855                 860                 


Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met Glu Gly Thr Val 
865                 870                 875                 880 


Asp Asn His His Phe Lys Cys Thr Ser Glu Gly Glu Gly Lys Pro Tyr 
                885                 890                 895     


Glu Gly Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly Gly Pro Leu 
            900                 905                 910         


Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr Gly Ser Lys 
        915                 920                 925             


Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe Lys Gln Ser 
    930                 935                 940                 


Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr Glu Asp Gly 
945                 950                 955                 960 


Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp Gly Cys Leu 
                965                 970                 975     


Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser Asn Gly Pro 
            980                 985                 990         


Val Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr Glu Thr Leu 
        995                 1000                1005            


Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met Ala Leu Lys 
    1010                1015                1020                


Leu Val Gly Gly Ser His Leu Ile Ala Asn Ile Lys Thr Thr Tyr Arg 
1025                1030                1035                1040


Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val Tyr Tyr Val 
                1045                1050                1055    


Asp Tyr Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu Thr Tyr Val 
            1060                1065                1070        


Glu Gln His Glu Val Ala Val Ala Arg Tyr Cys Asp Leu Pro Ser Lys 
        1075                1080                1085            


Leu Gly His Lys Leu Asn 
    1090                


<210>  21

<211>  898
<212>  PRT
<213>  Artificial

<220>
<223>  Plasmid JVGE_TtAGOm_FOKI

<400>  21
Met Gly Asn His Leu Gly Lys Thr Glu Val Phe Leu Asn Arg Phe Ala 
1               5                   10                  15      


Leu Arg Pro Leu Asn Pro Glu Glu Leu Arg Pro Trp Arg Leu Glu Val 
            20                  25                  30          


Val Leu Asp Pro Pro Pro Gly Arg Glu Glu Val Tyr Pro Leu Leu Ala 
        35                  40                  45              


Gln Val Ala Arg Arg Ala Gly Gly Val Thr Val Arg Met Gly Asp Gly 
    50                  55                  60                  


Leu Ala Ser Trp Ser Pro Pro Glu Val Leu Val Leu Glu Gly Thr Leu 
65                  70                  75                  80  


Ala Arg Met Gly Gln Thr Tyr Ala Tyr Arg Leu Tyr Pro Lys Gly Arg 
                85                  90                  95      


Arg Pro Leu Asp Pro Lys Asp Pro Gly Glu Arg Ser Val Leu Ser Ala 
            100                 105                 110         


Leu Ala Arg Arg Leu Leu Gln Glu Arg Leu Arg Arg Leu Glu Gly Val 
        115                 120                 125             


Trp Val Glu Gly Leu Ala Val Tyr Arg Arg Glu His Ala Arg Gly Pro 
    130                 135                 140                 


Gly Trp Arg Val Leu Gly Gly Ala Val Leu Asp Leu Trp Val Ser Asp 
145                 150                 155                 160 


Ser Gly Ala Phe Leu Leu Glu Val Asp Pro Ala Tyr Arg Ile Leu Cys 
                165                 170                 175     


Glu Met Ser Leu Glu Ala Trp Leu Ala Gln Gly His Pro Leu Pro Lys 
            180                 185                 190         


Arg Val Arg Asn Ala Tyr Asp Arg Arg Thr Trp Glu Leu Leu Arg Leu 
        195                 200                 205             


Gly Glu Glu Asp Pro Lys Glu Leu Pro Leu Pro Gly Gly Leu Ser Leu 
    210                 215                 220                 


Leu Asp Tyr His Ala Ser Lys Gly Arg Leu Gln Gly Arg Glu Gly Gly 
225                 230                 235                 240 


Arg Val Ala Trp Val Ala Asp Pro Lys Asp Pro Arg Lys Pro Ile Pro 
                245                 250                 255     


His Leu Thr Gly Leu Leu Val Pro Val Leu Thr Leu Glu Asp Leu His 
            260                 265                 270         


Glu Glu Glu Gly Ser Leu Ala Leu Ser Leu Pro Trp Glu Glu Arg Arg 
        275                 280                 285             


Arg Arg Thr Arg Glu Ile Ala Ser Trp Ile Gly Arg Arg Leu Gly Leu 
    290                 295                 300                 


Gly Thr Pro Glu Ala Val Arg Ala Gln Ala Tyr Arg Leu Ser Ile Pro 
305                 310                 315                 320 


Lys Leu Met Gly Arg Arg Ala Val Ser Lys Pro Ala Asp Ala Leu Arg 
                325                 330                 335     


Val Gly Phe Tyr Arg Ala Gln Glu Thr Ala Leu Ala Leu Leu Arg Leu 
            340                 345                 350         


Asp Gly Ala Gln Gly Trp Pro Glu Phe Leu Arg Arg Ala Leu Leu Arg 
        355                 360                 365             


Ala Phe Gly Ala Ser Gly Ala Ser Leu Arg Leu His Thr Leu His Ala 
    370                 375                 380                 


His Pro Ser Gln Gly Leu Ala Phe Arg Glu Ala Leu Arg Lys Ala Lys 
385                 390                 395                 400 


Glu Glu Gly Val Gln Ala Val Leu Val Leu Thr Pro Pro Met Ala Trp 
                405                 410                 415     


Glu Asp Arg Asn Arg Leu Lys Ala Leu Leu Leu Arg Glu Gly Leu Pro 
            420                 425                 430         


Ser Gln Ile Leu Asn Val Pro Leu Arg Glu Glu Glu Arg His Arg Trp 
        435                 440                 445             


Glu Asn Ala Leu Leu Gly Leu Leu Ala Lys Ala Gly Leu Gln Val Val 
    450                 455                 460                 


Ala Leu Ser Gly Ala Tyr Pro Ala Glu Leu Ala Val Gly Phe Ala Ala 
465                 470                 475                 480 


Gly Gly Arg Glu Ser Phe Arg Phe Gly Gly Ala Ala Cys Ala Val Gly 
                485                 490                 495     


Gly Asp Gly Gly His Leu Leu Trp Thr Leu Pro Glu Ala Gln Ala Gly 
            500                 505                 510         


Ala Arg Ile Pro Gln Glu Val Val Trp Asp Leu Leu Glu Glu Thr Leu 
        515                 520                 525             


Trp Ala Phe Arg Arg Lys Ala Gly Arg Leu Pro Ser Arg Val Leu Leu 
    530                 535                 540                 


Leu Arg Ala Gly Arg Val Pro Gln Asp Glu Phe Ala Leu Ala Leu Glu 
545                 550                 555                 560 


Ala Leu Ala Arg Glu Gly Ile Ala Tyr Asp Leu Val Ser Val Arg Lys 
                565                 570                 575     


Ser Gly Gly Gly Arg Val Tyr Pro Val Gln Gly Arg Leu Ala Asp Gly 
            580                 585                 590         


Leu Tyr Val Pro Leu Glu Asp Lys Thr Phe Leu Leu Leu Thr Val His 
        595                 600                 605             


Arg Asp Phe Arg Gly Thr Pro Arg Pro Leu Lys Leu Val His Glu Ala 
    610                 615                 620                 


Gly Asp Thr Pro Leu Glu Ala Leu Ala His Gln Ile Phe His Leu Thr 
625                 630                 635                 640 


Arg Leu Tyr Pro Ala Ser Gly Phe Ala Phe Pro Arg Leu Pro Ala Pro 
                645                 650                 655     


Leu His Leu Ala Asp Arg Leu Val Lys Glu Val Gly Arg Leu Gly Ile 
            660                 665                 670         


Arg His Leu Lys Glu Val Asp Arg Glu Lys Leu Phe Phe Val Gly Ser 
        675                 680                 685             


Gly Gly Asp Pro Gly Ser Gly Ile Ser Arg Ser Gln Leu Val Lys Ser 
    690                 695                 700                 


Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val 
705                 710                 715                 720 


Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln 
                725                 730                 735     


Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr 
            740                 745                 750         


Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala 
        755                 760                 765             


Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr 
    770                 775                 780                 


Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu 
785                 790                 795                 800 


Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn 
                805                 810                 815     


Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys 
            820                 825                 830         


Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu 
        835                 840                 845             


Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val 
    850                 855                 860                 


Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr 
865                 870                 875                 880 


Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ala 
                885                 890                 895     


Ala Asp 
        



<210>  22

<211>  42
<212>  DNA
<213>  artificial sequence

<220>
<223>  description of artificial sequence: synthetic polynucleotide

<220>
<223>  TRAC target 1

<400>  22
cacaaagtaa ggattctgat gtgtatatca cagacaaaac tg                        42


<210>  23

<211>  42
<212>  DNA
<213>  artificial sequence

<220>
<223>  description of artificial sequence: synthetic polynucleotide

<220>
<223>  TRAC target 2

<400>  23
catgaggtct atggacttca agagcaacag tgctgtggcc tg                        42


<210>  24

<211>  42
<212>  DNA
<213>  artificial sequence

<220>
<223>  description of artificial sequence: synthetic polynucleotide

<220>
<223>  TRAC target 3

<400>  24
caaagtaagg attctgatgt gtatatcaca gacaaaactg tg                        42


<210>  25

<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  description of artificial sequence: synthetic polynucleotide

<220>
<223>  TRAC target 7

<400>  25
ccacagatat ccagaaccct ga                                              22


<210>  26

<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  description of artificial sequence: synthetic polynucleotide

<220>
<223>  TRAC Oligo a target 1

<400>  26
cacaaagtaa ggattctgat g                                               21


<210>  27

<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  description of artificial sequence: synthetic polynucleotide

<220>
<223>  TRAC Oligo b target 1

<400>  27
cagttttgtc tgtgatatac a                                               21


<210>  28

<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  description of artificial sequence: synthetic polynucleotide

<220>
<223>  TRAC Oligo a target 2

<400>  28
catgaggtct atggacttca a                                               21


<210>  29

<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  description of artificial sequence: synthetic polynucleotide

<220>
<223>  TRAC Oligo b target 2

<400>  29
caggccacag cactgttgct c                                               21


<210>  30

<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  description of artificial sequence: synthetic polynucleotide

<220>
<223>  TRAC Oligo a target 3

<400>  30
caaagtaagg attctgatgt g                                               21


<210>  31

<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  description of artificial sequence: synthetic polynucleotide

<220>
<223>  TRAC Oligo b target 3

<400>  31
cacagttttg tctgtgatat a                                               21


<210>  32

<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  description of artificial sequence: synthetic polynucleotide

<220>
<223>  TRAC Oligo a target 7

<400>  32
cacagatatc cagaaccctg a                                               21


<210>  33

<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  description of artificial sequence: synthetic polynucleotide

<220>
<223>  TRAC Oligo b target 7a

<400>  33
cagggttctg gatatctgtg g                                               21


<210>  34

<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  description of artificial sequence: synthetic polynucleotide

<220>
<223>  TRAC Oligo b target 7b


<400>    
cagctggtac acggcagggt c                                            21


<210>  35

<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  description of artificial sequence: synthetic polynucleotide

<220>
<223>  TRAC Oligo b target 7c


<400>    
cactggattt agagtctctc a                                           21


<210>  36

<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  description of artificial sequence: synthetic polynucleotide

<220>
<223>  TRAC Oligo b target 7d


<400>    
cacggcaggg tcagggttct g                                          21


<210>  37

<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  description of artificial sequence: synthetic polynucleotide

<220>
<223>  TRAC Oligo b target 7e


<400>    
cagggtcagg gttctggata t                                         21






