               SEQUENCE LISTING

<110> ARSANIS Biosciences GmbH

<120> ANTI-STAPHYLOCOCCUS AUREUS ANTIBODY COMBINATION PREPARATION

<130> AR015P

<160> 423

<170> BiSSAP 1.3

<210> 1
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> partial antibody sequence

<400> 1
Tyr Ser Ile Ser Ser Gly Met Gly Trp Gly 
1               5                   10  

<210> 2
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> partial antibody sequence

<400> 2
Ser Ile Asp Gln Arg Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      



<210> 3
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> partial antibody sequence

<400> 3
Ala Arg Asp Ala Gly His Gly Val Asp Met Asp Val 
1               5                   10          

<210> 4
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> partial antibody sequence

<400> 4
Tyr Pro Ile Ser Ser Gly Met Gly Trp Gly 
1               5                   10  

<210> 5
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> partial antibody sequence

<400> 5
Tyr Ser Ile Ser Ser Gly Met Gly Trp Asp 
1               5                   10  

<210> 6
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> partial antibody sequence

<400> 6
Ser Val Asp Gln Arg Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      



<210> 7
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> partial antibody sequence

<400> 7
Arg Ile Asp Gln Arg Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      



<210> 8
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> partial antibody sequence

<400> 8
Arg Val Asp Gln Arg Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      



<210> 9
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> partial antibody sequence

<400> 9
Ser Ile Asp Gln Arg Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Glu Gly 
1               5                   10                  15      



<210> 10
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> partial antibody sequence

<400> 10
Ser Ile Asp Gln Arg Gly Ser Thr Tyr Tyr Asn Pro Pro Leu Glu Ser 
1               5                   10                  15      



<210> 11
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> partial antibody sequence

<400> 11
Ala Arg Asp Ala Gly His Gly Ala Asp Met Asp Val 
1               5                   10          

<210> 12
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> partial antibody sequence

<400> 12
Ala Arg Asp Ala Gly His Ala Val Asp Met Asp Val 
1               5                   10          

<210> 13
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> partial antibody sequence

<400> 13
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly 
            20                  25      

<210> 14
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> partial antibody sequence

<400> 14
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly 
            20                  25      

<210> 15
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> partial antibody sequence

<400> 15
Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  

<210> 16
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> partial antibody sequence

<400> 16
Trp Ile Arg Gln Pro Pro Gly Lys Gly Arg Glu Trp Ile Gly 
1               5                   10                  

<210> 17
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> partial antibody sequence

<400> 17
Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      
Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
            20                  25                  30  

<210> 18
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> partial antibody sequence

<400> 18
Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      
Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
            20                  25                  30  

<210> 19
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> partial antibody sequence

<400> 19
Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      

<210> 20
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-Sequence

<400> 20
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          
Met Gly Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Ile Gly Ser Ile Asp Gln Arg Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  
Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Ala Gly His Gly Val Asp Met Asp Val Trp Gly Lys Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 

<210> 21
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-Sequence

<400> 21
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          
Met Gly Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Ile Gly Ser Val Asp Gln Arg Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  
Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Ala Gly His Gly Ala Asp Met Asp Val Trp Gly Lys Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 

<210> 22
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-Sequence

<400> 22
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Pro Ile Ser Ser Gly 
            20                  25                  30          
Met Gly Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Ile Gly Arg Ile Asp Gln Arg Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  
Lys Ser Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Ala Gly His Gly Val Asp Met Asp Val Trp Gly Lys Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 

<210> 23
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-Sequence

<400> 23
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          
Met Gly Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Ile Gly Arg Val Asp Gln Arg Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  
Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Ala Gly His Gly Val Asp Met Asp Val Trp Gly Lys Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 

<210> 24
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-Sequence

<400> 24
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          
Met Gly Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Ile Gly Ser Ile Asp Gln Arg Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  
Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Ala Gly His Ala Val Asp Met Asp Val Trp Gly Lys Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 

<210> 25
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-Sequence

<400> 25
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          
Met Gly Trp Asp Trp Ile Arg Gln Pro Pro Gly Lys Gly Arg Glu Trp 
        35                  40                  45              
Ile Gly Ser Ile Asp Gln Arg Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  
Glu Gly Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Ala Gly His Gly Val Asp Met Asp Val Trp Gly Lys Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 

<210> 26
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-Sequence

<400> 26
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          
Met Gly Trp Asp Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Ile Gly Ser Ile Asp Gln Arg Gly Ser Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  
Glu Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Ala Gly His Gly Val Asp Met Asp Val Trp Gly Lys Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 

<210> 27
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-Sequence

<400> 27
Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          
Met Gly Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Ile Gly Ser Ile Asp Gln Arg Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  
Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Ala Gly His Ala Val Asp Met Asp Val Trp Gly Lys Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 

<210> 28
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-Sequence

<400> 28
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          
Met Gly Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Ile Gly Ser Ile Asp Gln Arg Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  
Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Ala Gly His Ala Val Asp Met Asp Val Trp Gly Lys Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 

<210> 29
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-Sequence

<400> 29
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          
Met Gly Trp Asp Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Ile Gly Ser Ile Asp Gln Arg Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  
Glu Gly Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Ala Gly His Gly Val Asp Met Asp Val Trp Gly Lys Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 

<210> 30
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-Sequence

<400> 30
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          
Met Gly Trp Asp Trp Ile Arg Gln Pro Pro Gly Lys Gly Arg Glu Trp 
        35                  40                  45              
Ile Gly Ser Ile Asp Gln Arg Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  
Glu Gly Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Ala Gly His Gly Val Asp Met Asp Val Trp Gly Lys Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 

<210> 31
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-Sequence

<400> 31
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          
Met Gly Trp Asp Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Ile Gly Ser Ile Asp Gln Arg Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  
Glu Gly Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Ala Gly His Gly Val Asp Met Asp Val Trp Gly Lys Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 

<210> 32
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> partial antibody sequence

<400> 32
Arg Ala Ser Gln Gly Ile Ser Arg Trp Leu Ala 
1               5                   10      

<210> 33
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> partial antibody sequence

<400> 33
Ala Ala Ser Ser Leu Gln Ser 
1               5           

<210> 34
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> partial antibody sequence

<400> 34
Gln Gln Gly Tyr Val Phe Pro Leu Thr 
1               5                   

<210> 35
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> partial antibody sequence

<400> 35
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys 
            20              

<210> 36
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> partial antibody sequence

<400> 36
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  

<210> 37
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> partial antibody sequence

<400> 37
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          



<210> 38
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> partial antibody sequence

<400> 38
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  

<210> 39
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-Sequence

<400> 39
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Arg Trp 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Val Phe Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 40
<211> 468
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-Sequence

<400> 40
Met Glu Leu Gly Leu Cys Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      
Val Gln Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          
Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile 
        35                  40                  45              
Ser Ser Gly Met Gly Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  
Leu Glu Trp Ile Gly Ser Ile Asp Gln Arg Gly Ser Thr Tyr Tyr Asn 
65                  70                  75                  80  
Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn 
                85                  90                  95      
Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Asp Ala Gly His Gly Val Asp Met Asp Val Trp 
        115                 120                 125             
Gly Lys Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 
Ser Pro Gly Lys 
465             

<210> 41
<211> 458
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-Sequence

<400> 41
Met Glu Leu Gly Leu Cys Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      
Val Gln Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          
Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile 
        35                  40                  45              
Ser Ser Gly Met Gly Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  
Leu Glu Trp Ile Gly Ser Val Asp Gln Arg Gly Ser Thr Tyr Tyr Asn 
65                  70                  75                  80  
Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn 
                85                  90                  95      
Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Asp Ala Gly His Gly Ala Asp Met Asp Val Trp 
        115                 120                 125             
Gly Lys Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             
Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455             

<210> 42
<211> 456
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-Sequence

<400> 42
Met Glu Leu Gly Leu Cys Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      
Val Gln Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          
Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Pro Ile 
        35                  40                  45              
Ser Ser Gly Met Gly Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  
Leu Glu Trp Ile Gly Arg Ile Asp Gln Arg Gly Ser Thr Tyr Tyr Asn 
65                  70                  75                  80  
Pro Ser Leu Lys Ser Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn 
                85                  90                  95      
Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Asp Ala Gly His Gly Val Asp Met Asp Val Trp 
        115                 120                 125             
Gly Lys Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             
Met His Glu Ala Leu His Asn His 
    450                 455     

<210> 43
<211> 456
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-Sequence

<400> 43
Met Glu Leu Gly Leu Cys Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      
Val Gln Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          
Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile 
        35                  40                  45              
Ser Ser Gly Met Gly Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  
Leu Glu Trp Ile Gly Arg Val Asp Gln Arg Gly Ser Thr Tyr Tyr Asn 
65                  70                  75                  80  
Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn 
                85                  90                  95      
Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Asp Ala Gly His Gly Val Asp Met Asp Val Trp 
        115                 120                 125             
Gly Lys Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             
Met His Glu Ala Leu His Asn His 
    450                 455     

<210> 44
<211> 468
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-Sequence

<400> 44
Met Glu Leu Gly Leu Cys Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      
Val Gln Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg 
            20                  25                  30          
Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile 
        35                  40                  45              
Ser Ser Gly Met Gly Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  
Leu Glu Trp Ile Gly Ser Ile Asp Gln Arg Gly Ser Thr Tyr Tyr Asn 
65                  70                  75                  80  
Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn 
                85                  90                  95      
Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Asp Ala Gly His Ala Val Asp Met Asp Val Trp 
        115                 120                 125             
Gly Lys Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 
Ser Pro Gly Lys 
465             

<210> 45
<211> 468
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-Sequence

<400> 45
Met Glu Leu Gly Leu Cys Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      
Val Gln Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          
Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile 
        35                  40                  45              
Ser Ser Gly Met Gly Trp Asp Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  
Arg Glu Trp Ile Gly Ser Ile Asp Gln Arg Gly Ser Thr Tyr Tyr Asn 
65                  70                  75                  80  
Pro Ser Leu Glu Gly Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn 
                85                  90                  95      
Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Asp Ala Gly His Gly Val Asp Met Asp Val Trp 
        115                 120                 125             
Gly Lys Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 
Ser Pro Gly Lys 
465             

<210> 46
<211> 468
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-Sequence

<400> 46
Met Glu Leu Gly Leu Cys Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      
Val Gln Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          
Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile 
        35                  40                  45              
Ser Ser Gly Met Gly Trp Asp Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  
Leu Glu Trp Ile Gly Ser Ile Asp Gln Arg Gly Ser Thr Tyr Tyr Asn 
65                  70                  75                  80  
Pro Pro Leu Glu Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn 
                85                  90                  95      
Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Asp Ala Gly His Gly Val Asp Met Asp Val Trp 
        115                 120                 125             
Gly Lys Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 
Ser Pro Gly Lys 
465             

<210> 47
<211> 467
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-Sequence

<400> 47
Met Glu Leu Gly Leu Cys Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      
Val Gln Cys Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg 
            20                  25                  30          
Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile 
        35                  40                  45              
Ser Ser Gly Met Gly Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  
Leu Glu Trp Ile Gly Ser Ile Asp Gln Arg Gly Ser Thr Tyr Tyr Asn 
65                  70                  75                  80  
Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn 
                85                  90                  95      
Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Asp Ala Gly His Ala Val Asp Met Asp Val Trp 
        115                 120                 125             
Gly Lys Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 
Ser Pro Gly 
465         

<210> 48
<211> 468
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-Sequence

<400> 48
Met Glu Leu Gly Leu Cys Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      
Val Gln Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          
Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile 
        35                  40                  45              
Ser Ser Gly Met Gly Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  
Leu Glu Trp Ile Gly Ser Ile Asp Gln Arg Gly Ser Thr Tyr Tyr Asn 
65                  70                  75                  80  
Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn 
                85                  90                  95      
Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Asp Ala Gly His Ala Val Asp Met Asp Val Trp 
        115                 120                 125             
Gly Lys Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 
Ser Pro Gly Lys 
465             

<210> 49
<211> 468
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-Sequence

<400> 49
Met Glu Leu Gly Leu Cys Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      
Val Gln Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          
Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile 
        35                  40                  45              
Ser Ser Gly Met Gly Trp Asp Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  
Leu Glu Trp Ile Gly Ser Ile Asp Gln Arg Gly Ser Thr Tyr Tyr Asn 
65                  70                  75                  80  
Pro Ser Leu Glu Gly Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn 
                85                  90                  95      
Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Asp Ala Gly His Gly Val Asp Met Asp Val Trp 
        115                 120                 125             
Gly Lys Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 
Ser Pro Gly Lys 
465             

<210> 50
<211> 468
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-Sequence

<400> 50
Met Glu Leu Gly Leu Cys Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      
Val Gln Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          
Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile 
        35                  40                  45              
Ser Ser Gly Met Gly Trp Asp Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  
Arg Glu Trp Ile Gly Ser Ile Asp Gln Arg Gly Ser Thr Tyr Tyr Asn 
65                  70                  75                  80  
Pro Ser Leu Glu Gly Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn 
                85                  90                  95      
Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Asp Ala Gly His Gly Val Asp Met Asp Val Trp 
        115                 120                 125             
Gly Lys Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 
Ser Pro Gly Lys 
465             

<210> 51
<211> 468
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-Sequence

<400> 51
Met Glu Leu Gly Leu Cys Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      
Val Gln Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          
Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile 
        35                  40                  45              
Ser Ser Gly Met Gly Trp Asp Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  
Leu Glu Trp Ile Gly Ser Ile Asp Gln Arg Gly Ser Thr Tyr Tyr Asn 
65                  70                  75                  80  
Pro Ser Leu Glu Gly Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn 
                85                  90                  95      
Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Asp Ala Gly His Gly Val Asp Met Asp Val Trp 
        115                 120                 125             
Gly Lys Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 
Ser Pro Gly Lys 
465             

<210> 52
<211> 233
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-Sequence

<400> 52
Met Glu Leu Gly Leu Cys Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      
Val Gln Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala 
            20                  25                  30          
Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile 
        35                  40                  45              
Ser Arg Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  
Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      
Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Val 
            100                 105                 110         
Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             
Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 
Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 
Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     
Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         
Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             
Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 
Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             

<210> 53
<211> 879
<212> DNA
<213> Staphylococcus aureus

<400> 53
gccgacagcg acatcaacat caaaacgggc acgacggaca ttggctcaaa tacgacggtg      60

aaaacgggcg atctggttac ctatgacaaa gaaaacggca tgcataaaaa agtgttttat     120

agtttcatcg atgacaaaaa ccacaacaaa aaactgctgg tcattcgtac caaaggcacg     180

atcgcaggcc agtatcgcgt gtacagcgaa gaaggcgcta ataaatcagg tctggcatgg     240

ccgtcggctt ttaaagttca gctgcaactg ccggataacg aagtcgcgca aattagcgac     300

tattacccgc gtaactctat cgataccaaa gaatacatgt ctaccctgac gtacggcttc     360

aacggtaatg ttaccggcga tgacacgggt aaaattggcg gtctgatcgg cgccaacgtg     420

agcattggtc ataccctgaa atatgttcag ccggacttta aaaccatcct ggaatctccg     480

acggataaaa aagtgggctg gaaagttatc ttcaacaaca tggttaacca gaactggggt     540

ccgtatgatc gtgactcatg gaacccggtc tacggcaatc aactgtttat gaaaacccgc     600

aacggttcga tgaaagcggc cgataacttc ctggacccga ataaagcgag ctctctgctg     660

agttccggct ttagtccgga cttcgcgacc gtgattacga tggatcgcaa agcctccaaa     720

cagcaaacca atattgatgt catctatgaa cgtgtgcgcg atgactacca gctgcactgg     780

accagcacga actggaaagg taccaatacg aaagataaat ggattgaccg ctcctcggaa     840

cgctacaaaa ttgactggga aaaagaagaa atgacgaac                            879


<210> 54
<211> 293
<212> PRT
<213> Staphylococcus aureus

<400> 54
Ala Asp Ser Asp Ile Asn Ile Lys Thr Gly Thr Thr Asp Ile Gly Ser 
1               5                   10                  15      
Asn Thr Thr Val Lys Thr Gly Asp Leu Val Thr Tyr Asp Lys Glu Asn 
            20                  25                  30          
Gly Met His Lys Lys Val Phe Tyr Ser Phe Ile Asp Asp Lys Asn His 
        35                  40                  45              
Asn Lys Lys Leu Leu Val Ile Arg Thr Lys Gly Thr Ile Ala Gly Gln 
    50                  55                  60                  
Tyr Arg Val Tyr Ser Glu Glu Gly Ala Asn Lys Ser Gly Leu Ala Trp 
65                  70                  75                  80  
Pro Ser Ala Phe Lys Val Gln Leu Gln Leu Pro Asp Asn Glu Val Ala 
                85                  90                  95      
Gln Ile Ser Asp Tyr Tyr Pro Arg Asn Ser Ile Asp Thr Lys Glu Tyr 
            100                 105                 110         
Met Ser Thr Leu Thr Tyr Gly Phe Asn Gly Asn Val Thr Gly Asp Asp 
        115                 120                 125             
Thr Gly Lys Ile Gly Gly Leu Ile Gly Ala Asn Val Ser Ile Gly His 
    130                 135                 140                 
Thr Leu Lys Tyr Val Gln Pro Asp Phe Lys Thr Ile Leu Glu Ser Pro 
145                 150                 155                 160 
Thr Asp Lys Lys Val Gly Trp Lys Val Ile Phe Asn Asn Met Val Asn 
                165                 170                 175     
Gln Asn Trp Gly Pro Tyr Asp Arg Asp Ser Trp Asn Pro Val Tyr Gly 
            180                 185                 190         
Asn Gln Leu Phe Met Lys Thr Arg Asn Gly Ser Met Lys Ala Ala Asp 
        195                 200                 205             
Asn Phe Leu Asp Pro Asn Lys Ala Ser Ser Leu Leu Ser Ser Gly Phe 
    210                 215                 220                 
Ser Pro Asp Phe Ala Thr Val Ile Thr Met Asp Arg Lys Ala Ser Lys 
225                 230                 235                 240 
Gln Gln Thr Asn Ile Asp Val Ile Tyr Glu Arg Val Arg Asp Asp Tyr 
                245                 250                 255     
Gln Leu His Trp Thr Ser Thr Asn Trp Lys Gly Thr Asn Thr Lys Asp 
            260                 265                 270         
Lys Trp Ile Asp Arg Ser Ser Glu Arg Tyr Lys Ile Asp Trp Glu Lys 
        275                 280                 285             
Glu Glu Met Thr Asn 
    290             

<210> 55
<211> 852
<212> DNA
<213> Staphylococcus aureus

<400> 55
gacaacaaca ttgaaaacat tggtgatggc gcagaagtgg tgaaacgcac ggaagatacc      60

tcaagcgata aatggggtgt gacgcagaac attcagttcg atttcgtcaa agacaaaaaa     120

tacaacaaag atgcactgat tctgaaaatg caaggcttta tcaacagcaa aaccacgtac     180

tacaactaca aaaacaccga ccatatcaaa gctatgcgtt ggccgttcca gtacaatatc     240

ggtctgaaaa cgaacgatcc gaatgttgac ctgatcaact acctgccgaa aaacaaaatc     300

gattcagtga acgtttcgca aaccctgggc tacaatatcg gcggtaactt taatagtggc     360

ccgtccaccg gcggtaacgg tagcttcaac tactctaaaa cgatcagtta caaccagcaa     420

aactacatct ctgaagtcga acgtcagaac agcaaatctg tgcaatgggg cattaaagcg     480

aattccttta tcacctcact gggcaaaatg tcgggtcatg atccgaacct gtttgtgggt     540

tataaaccgt acagccagaa cccgcgcgat tatttcgttc cggacaatga actgccgccg     600

ctggtccatt ctggctttaa cccgagtttc attgcaaccg tgagccacga aaaaggctcg     660

ggtgatacca gcgaatttga aatcacgtat ggtcgcaata tggacgttac ccatgcgacg     720

cgtcgcacca cgcactatgg caactcctac ctggaaggtt cacgtattca caatgccttc     780

gttaaccgca attacacggt gaaatacgaa gtcaactgga aaacgcacga aatcaaagtg     840

aaaggtcata ac                                                         852


<210> 56
<211> 284
<212> PRT
<213> Staphylococcus aureus

<400> 56
Asp Asn Asn Ile Glu Asn Ile Gly Asp Gly Ala Glu Val Val Lys Arg 
1               5                   10                  15      
Thr Glu Asp Thr Ser Ser Asp Lys Trp Gly Val Thr Gln Asn Ile Gln 
            20                  25                  30          
Phe Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Leu 
        35                  40                  45              
Lys Met Gln Gly Phe Ile Asn Ser Lys Thr Thr Tyr Tyr Asn Tyr Lys 
    50                  55                  60                  
Asn Thr Asp His Ile Lys Ala Met Arg Trp Pro Phe Gln Tyr Asn Ile 
65                  70                  75                  80  
Gly Leu Lys Thr Asn Asp Pro Asn Val Asp Leu Ile Asn Tyr Leu Pro 
                85                  90                  95      
Lys Asn Lys Ile Asp Ser Val Asn Val Ser Gln Thr Leu Gly Tyr Asn 
            100                 105                 110         
Ile Gly Gly Asn Phe Asn Ser Gly Pro Ser Thr Gly Gly Asn Gly Ser 
        115                 120                 125             
Phe Asn Tyr Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr Ile Ser 
    130                 135                 140                 
Glu Val Glu Arg Gln Asn Ser Lys Ser Val Gln Trp Gly Ile Lys Ala 
145                 150                 155                 160 
Asn Ser Phe Ile Thr Ser Leu Gly Lys Met Ser Gly His Asp Pro Asn 
                165                 170                 175     
Leu Phe Val Gly Tyr Lys Pro Tyr Ser Gln Asn Pro Arg Asp Tyr Phe 
            180                 185                 190         
Val Pro Asp Asn Glu Leu Pro Pro Leu Val His Ser Gly Phe Asn Pro 
        195                 200                 205             
Ser Phe Ile Ala Thr Val Ser His Glu Lys Gly Ser Gly Asp Thr Ser 
    210                 215                 220                 
Glu Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His Ala Thr 
225                 230                 235                 240 
Arg Arg Thr Thr His Tyr Gly Asn Ser Tyr Leu Glu Gly Ser Arg Ile 
                245                 250                 255     
His Asn Ala Phe Val Asn Arg Asn Tyr Thr Val Lys Tyr Glu Val Asn 
            260                 265                 270         
Trp Lys Thr His Glu Ile Lys Val Lys Gly His Asn 
        275                 280                 

<210> 57
<211> 903
<212> DNA
<213> Staphylococcus aureus

<400> 57
gcgcagcaca tcacgccggt ctccgaaaaa aaagttgacg acaaaatcac cctgtataaa      60

acgacggcca cgagcgactc tgacaaactg aaaatttctc agatcctgac cttcaacttc     120

atcaaagata aaagttacga taaagacacg ctgattctga aagcggccgg taacatctat     180

tctggctaca ccaaaccgaa tccgaaagac acgatcagct ctcaattcta ctggggttcc     240

aaatacaaca tctcaatcaa cagtgattcc aacgactccg tcaatgtggt tgattatgca     300

ccgaaaaacc agaatgaaga attccaagtc cagcaaaccg tgggctatag ttacggcggt     360

gacattaaca tctcgaatgg tctgagcggc ggtggcaacg gctcaaaatc gttcagcgaa     420

acgatcaact acaaacagga atcttaccgt accagtctgg ataaacgcac gaatttcaag     480

aaaattggtt gggacgttga agcgcataaa atcatgaaca atggttgggg cccgtatggc     540

cgtgattctt atcacagtac ctacggtaac gaaatgtttc tgggctcccg ccagtcaaac     600

ctgaatgccg gtcaaaattt cctggaatac cataaaatgc cggttctgag ccgtggtaac     660

tttaatccgg aattcattgg cgtcctgtcg cgcaaacaga acgcagcgaa aaaatctaaa     720

atcaccgtga cgtatcagcg tgaaatggat cgctacacca acttttggaa tcaactgcat     780

tggatcggca acaactacaa agatgaaaac cgtgccaccc acacgagcat ctacgaagtt     840

gactgggaaa accacacggt gaaactgatt gatacccaaa gtaaagaaaa aaacccgatg     900

tcg                                                                   903


<210> 58
<211> 301
<212> PRT
<213> Staphylococcus aureus

<400> 58
Ala Gln His Ile Thr Pro Val Ser Glu Lys Lys Val Asp Asp Lys Ile 
1               5                   10                  15      
Thr Leu Tyr Lys Thr Thr Ala Thr Ser Asp Ser Asp Lys Leu Lys Ile 
            20                  25                  30          
Ser Gln Ile Leu Thr Phe Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys 
        35                  40                  45              
Asp Thr Leu Ile Leu Lys Ala Ala Gly Asn Ile Tyr Ser Gly Tyr Thr 
    50                  55                  60                  
Lys Pro Asn Pro Lys Asp Thr Ile Ser Ser Gln Phe Tyr Trp Gly Ser 
65                  70                  75                  80  
Lys Tyr Asn Ile Ser Ile Asn Ser Asp Ser Asn Asp Ser Val Asn Val 
                85                  90                  95      
Val Asp Tyr Ala Pro Lys Asn Gln Asn Glu Glu Phe Gln Val Gln Gln 
            100                 105                 110         
Thr Val Gly Tyr Ser Tyr Gly Gly Asp Ile Asn Ile Ser Asn Gly Leu 
        115                 120                 125             
Ser Gly Gly Gly Asn Gly Ser Lys Ser Phe Ser Glu Thr Ile Asn Tyr 
    130                 135                 140                 
Lys Gln Glu Ser Tyr Arg Thr Ser Leu Asp Lys Arg Thr Asn Phe Lys 
145                 150                 155                 160 
Lys Ile Gly Trp Asp Val Glu Ala His Lys Ile Met Asn Asn Gly Trp 
                165                 170                 175     
Gly Pro Tyr Gly Arg Asp Ser Tyr His Ser Thr Tyr Gly Asn Glu Met 
            180                 185                 190         
Phe Leu Gly Ser Arg Gln Ser Asn Leu Asn Ala Gly Gln Asn Phe Leu 
        195                 200                 205             
Glu Tyr His Lys Met Pro Val Leu Ser Arg Gly Asn Phe Asn Pro Glu 
    210                 215                 220                 
Phe Ile Gly Val Leu Ser Arg Lys Gln Asn Ala Ala Lys Lys Ser Lys 
225                 230                 235                 240 
Ile Thr Val Thr Tyr Gln Arg Glu Met Asp Arg Tyr Thr Asn Phe Trp 
                245                 250                 255     
Asn Gln Leu His Trp Ile Gly Asn Asn Tyr Lys Asp Glu Asn Arg Ala 
            260                 265                 270         
Thr His Thr Ser Ile Tyr Glu Val Asp Trp Glu Asn His Thr Val Lys 
        275                 280                 285             
Leu Ile Asp Thr Gln Ser Lys Glu Lys Asn Pro Met Ser 
    290                 295                 300     

<210> 59
<211> 849
<212> DNA
<213> Staphylococcus aureus

<400> 59
aatacgaata tcgaaaatat cggcgacggc gcagaagtta tcaaacgcac ggaagatgtc      60

agcagcaaaa aatggggtgt tacgcagaat gttcagttcg atttcgtcaa agacaaaaaa     120

tacaacaaag atgcactgat tgtgaaaatg caaggcttta tcaattctcg taccagtttc     180

tccgacgtta aaggcagtgg ttatgaactg acgaaacgca tgatttggcc gtttcagtac     240

aacatcggtc tgaccacgaa agatccgaac gtttccctga tcaactacct gccgaaaaac     300

aaaatcgaaa ccacggacgt cggccagacc ctgggttaca acattggcgg taattttcaa     360

agcgctccgt ctatcggcgg taacggctca ttcaattact cgaaaaccat tagctatacg     420

cagaaaagtt acgtgtccga agttgataaa caaaactcaa aatcggtcaa atggggcgtg     480

aaagcgaacg aatttgtcac cccggatggt aaaaaatctg cccatgaccg ttacctgttt     540

gtgcagtcgc cgaatggtcc gacgggtagc gcacgtgaat actttgcccc ggataatcag     600

ctgccgccgc tggtgcaatc tggctttaac ccgagtttca ttaccacgct gagccatgaa     660

aaaggcagct ctgatacctc cgaattcgaa atttcatatg gtcgtaatct ggacatcacc     720

tacgcaacgc tgtttccgcg taccggtatc tatgcagaac gcaaacacaa cgcttttgtt     780

aaccgcaatt tcgttgtccg ctacgaagtg aactggaaaa cccatgaaat caaagtgaaa     840

ggccataac                                                             849


<210> 60
<211> 283
<212> PRT
<213> Staphylococcus aureus

<400> 60
Asn Thr Asn Ile Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg 
1               5                   10                  15      
Thr Glu Asp Val Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln 
            20                  25                  30          
Phe Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val 
        35                  40                  45              
Lys Met Gln Gly Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys 
    50                  55                  60                  
Gly Ser Gly Tyr Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr 
65                  70                  75                  80  
Asn Ile Gly Leu Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr 
                85                  90                  95      
Leu Pro Lys Asn Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly 
            100                 105                 110         
Tyr Asn Ile Gly Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn 
        115                 120                 125             
Gly Ser Phe Asn Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr 
    130                 135                 140                 
Val Ser Glu Val Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val 
145                 150                 155                 160 
Lys Ala Asn Glu Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp 
                165                 170                 175     
Arg Tyr Leu Phe Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg 
            180                 185                 190         
Glu Tyr Phe Ala Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly 
        195                 200                 205             
Phe Asn Pro Ser Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser 
    210                 215                 220                 
Asp Thr Ser Glu Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr 
225                 230                 235                 240 
Tyr Ala Thr Leu Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His 
                245                 250                 255     
Asn Ala Phe Val Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp 
            260                 265                 270         
Lys Thr His Glu Ile Lys Val Lys Gly His Asn 
        275                 280             

<210> 61
<211> 903
<212> DNA
<213> Staphylococcus aureus

<400> 61
gcccaacaca ttacgccggt ctcggaaaaa aaagtggatg acaaaatcac gctgtataaa      60

acgacggcaa cctcagataa cgacaaactg aacattagtc agatcctgac cttcaacttc     120

atcaaagata aatcctacga taaagacacg ctggtgctga aagcggccgg caacattaat     180

tcaggttaca aaaaaccgaa cccgaaagac tataattact cgcagtttta ttggggcggt     240

aaatacaacg tcagcgtgag ctctgaatct aacgatgcag tcaatgtggt tgactatgct     300

ccgaaaaacc agaatgaaga atttcaagtg cagcaaaccc tgggctatag ctacggcggt     360

gatattaaca tctcaaatgg cctgtcgggc ggtctgaacg gttcgaaaag cttctctgaa     420

accatcaact acaaacagga aagctaccgt accacgattg atcgcaaaac gaaccataaa     480

tctatcggct ggggtgttga agcgcacaaa attatgaaca atggctgggg tccgtatggc     540

cgtgattcct atgacccgac ctacggtaat gaactgtttc tgggcggtcg ccagagttcc     600

tcaaacgcgg gccaaaattt cctgccgacg catcagatgc cgctgctggc acgtggtaac     660

tttaatccgg aattcatcag tgtgctgtcc cacaaacaaa acgataccaa aaaatctaaa     720

atcaaagtta cgtatcaacg tgaaatggac cgctacacca accagtggaa tcgcctgcat     780

tgggttggta acaactacaa aaaccagaac accgttacgt tcacctctac gtacgaagtc     840

gattggcaaa accatacggt caaactgatt ggcacggaca gcaaagaaac gaacccgggc     900

gtc                                                                   903


<210> 62
<211> 301
<212> PRT
<213> Staphylococcus aureus

<400> 62
Ala Gln His Ile Thr Pro Val Ser Glu Lys Lys Val Asp Asp Lys Ile 
1               5                   10                  15      
Thr Leu Tyr Lys Thr Thr Ala Thr Ser Asp Asn Asp Lys Leu Asn Ile 
            20                  25                  30          
Ser Gln Ile Leu Thr Phe Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys 
        35                  40                  45              
Asp Thr Leu Val Leu Lys Ala Ala Gly Asn Ile Asn Ser Gly Tyr Lys 
    50                  55                  60                  
Lys Pro Asn Pro Lys Asp Tyr Asn Tyr Ser Gln Phe Tyr Trp Gly Gly 
65                  70                  75                  80  
Lys Tyr Asn Val Ser Val Ser Ser Glu Ser Asn Asp Ala Val Asn Val 
                85                  90                  95      
Val Asp Tyr Ala Pro Lys Asn Gln Asn Glu Glu Phe Gln Val Gln Gln 
            100                 105                 110         
Thr Leu Gly Tyr Ser Tyr Gly Gly Asp Ile Asn Ile Ser Asn Gly Leu 
        115                 120                 125             
Ser Gly Gly Leu Asn Gly Ser Lys Ser Phe Ser Glu Thr Ile Asn Tyr 
    130                 135                 140                 
Lys Gln Glu Ser Tyr Arg Thr Thr Ile Asp Arg Lys Thr Asn His Lys 
145                 150                 155                 160 
Ser Ile Gly Trp Gly Val Glu Ala His Lys Ile Met Asn Asn Gly Trp 
                165                 170                 175     
Gly Pro Tyr Gly Arg Asp Ser Tyr Asp Pro Thr Tyr Gly Asn Glu Leu 
            180                 185                 190         
Phe Leu Gly Gly Arg Gln Ser Ser Ser Asn Ala Gly Gln Asn Phe Leu 
        195                 200                 205             
Pro Thr His Gln Met Pro Leu Leu Ala Arg Gly Asn Phe Asn Pro Glu 
    210                 215                 220                 
Phe Ile Ser Val Leu Ser His Lys Gln Asn Asp Thr Lys Lys Ser Lys 
225                 230                 235                 240 
Ile Lys Val Thr Tyr Gln Arg Glu Met Asp Arg Tyr Thr Asn Gln Trp 
                245                 250                 255     
Asn Arg Leu His Trp Val Gly Asn Asn Tyr Lys Asn Gln Asn Thr Val 
            260                 265                 270         
Thr Phe Thr Ser Thr Tyr Glu Val Asp Trp Gln Asn His Thr Val Lys 
        275                 280                 285             
Leu Ile Gly Thr Asp Ser Lys Glu Thr Asn Pro Gly Val 
    290                 295                 300     

<210> 63
<211> 840
<212> DNA
<213> Staphylococcus aureus

<400> 63
gaaaacaaaa tcgaagacat cggccaaggt gctgaaatca tcaaacgcac gcaagacatc      60

acgagtaaac gcctggcaat cacgcagaat attcagttcg atttcgtgaa agacaaaaaa     120

tacaacaaag atgcactggt ggttaaaatg caaggcttta tcagctctcg taccacgtac     180

agcgatctga aaaaatatcc gtacattaaa cgcatgatct ggccgttcca gtacaacatc     240

agtctgaaaa ccaaagattc caacgtggac ctgattaatt acctgccgaa aaacaaaatc     300

gatagtgcgg acgtttccca gaaactgggc tataacattg gcggtaattt tcaatcagcc     360

ccgtcgatcg gcggtagtgg ttccttcaat tactcaaaaa ccatctcgta caaccagaaa     420

aattacgtta cggaagtcga aagccaaaac tctaaaggcg tgaaatgggg tgttaaagcg     480

aattcatttg tcaccccgaa cggccaggtg tcggcgtatg atcagtacct gtttgcacaa     540

gacccgacgg gtccggcagc acgtgattat ttcgttccgg acaatcagct gccgccgctg     600

attcaaagcg gctttaaccc gtctttcatc accacgctgt cccatgaacg tggcaaaggt     660

gataaaagcg aatttgaaat tacctatggt cgcaacatgg atgcaaccta tgcttacgtt     720

acgcgtcatc gcctggcagt cgatcgtaaa cacgacgctt tcaaaaaccg caatgtcacc     780

gtgaaatacg aagtcaactg gaaaacgcac gaagtcaaaa tcaaatcaat caccccgaaa     840


<210> 64
<211> 280
<212> PRT
<213> Staphylococcus aureus

<400> 64
Glu Asn Lys Ile Glu Asp Ile Gly Gln Gly Ala Glu Ile Ile Lys Arg 
1               5                   10                  15      
Thr Gln Asp Ile Thr Ser Lys Arg Leu Ala Ile Thr Gln Asn Ile Gln 
            20                  25                  30          
Phe Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Val Val 
        35                  40                  45              
Lys Met Gln Gly Phe Ile Ser Ser Arg Thr Thr Tyr Ser Asp Leu Lys 
    50                  55                  60                  
Lys Tyr Pro Tyr Ile Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile 
65                  70                  75                  80  
Ser Leu Lys Thr Lys Asp Ser Asn Val Asp Leu Ile Asn Tyr Leu Pro 
                85                  90                  95      
Lys Asn Lys Ile Asp Ser Ala Asp Val Ser Gln Lys Leu Gly Tyr Asn 
            100                 105                 110         
Ile Gly Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Ser Gly Ser 
        115                 120                 125             
Phe Asn Tyr Ser Lys Thr Ile Ser Tyr Asn Gln Lys Asn Tyr Val Thr 
    130                 135                 140                 
Glu Val Glu Ser Gln Asn Ser Lys Gly Val Lys Trp Gly Val Lys Ala 
145                 150                 155                 160 
Asn Ser Phe Val Thr Pro Asn Gly Gln Val Ser Ala Tyr Asp Gln Tyr 
                165                 170                 175     
Leu Phe Ala Gln Asp Pro Thr Gly Pro Ala Ala Arg Asp Tyr Phe Val 
            180                 185                 190         
Pro Asp Asn Gln Leu Pro Pro Leu Ile Gln Ser Gly Phe Asn Pro Ser 
        195                 200                 205             
Phe Ile Thr Thr Leu Ser His Glu Arg Gly Lys Gly Asp Lys Ser Glu 
    210                 215                 220                 
Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Ala Thr Tyr Ala Tyr Val 
225                 230                 235                 240 
Thr Arg His Arg Leu Ala Val Asp Arg Lys His Asp Ala Phe Lys Asn 
                245                 250                 255     
Arg Asn Val Thr Val Lys Tyr Glu Val Asn Trp Lys Thr His Glu Val 
            260                 265                 270         
Lys Ile Lys Ser Ile Thr Pro Lys 
        275                 280 

<210> 65
<211> 858
<212> DNA
<213> Staphylococcus aureus

<400> 65
gcaaacgaca cggaagacat cggcaaaggt tcagacatcg aaatcatcaa acgcacggaa      60

gacaaaacga gcaataaatg gggtgtgacc cagaacattc aattcgattt cgtgaaagac     120

aaaaaataca ataaagatgc gctgattctg aaaatgcagg gctttatcag ctctcgtacc     180

acgtactaca actacaagaa aaccaaccat gttaaagcca tgcgctggcc gttccaatac     240

aacatcggtc tgaaaacgaa tgacaaatat gtcagtctga ttaactacct gccgaaaaat     300

aaaatcgaat cgaccaacgt gagccagacg ctgggctata acattggcgg taattttcaa     360

tccgcaccgt cactgggcgg taacggttca ttcaattact caaaatcgat cagctatacc     420

cagcaaaact acgtgtctga agttgaacag caaaattcta aaagtgtcct gtggggcgtg     480

aaagcgaata gctttgccac ggaatctggt cagaaaagtg catttgattc cgacctgttc     540

gtgggctata aaccgcattc aaaagatccg cgtgactact tcgtgccgga ttcggaactg     600

ccgccgctgg ttcagtcagg ttttaacccg tcgttcattg ctaccgttag tcacgaaaaa     660

ggcagttccg atacctccga atttgaaatt acgtatggtc gtaatatgga cgtcacccat     720

gcaatcaaac gcagcacgca ctatggcaac tcttacctgg atggtcatcg tgttcacaat     780

gcttttgtca accgcaatta tacggtgaaa tacgaagtca actggaaaac gcacgaaatc     840

aaagtcaaag gtcaaaac                                                   858


<210> 66
<211> 286
<212> PRT
<213> Staphylococcus aureus

<400> 66
Ala Asn Asp Thr Glu Asp Ile Gly Lys Gly Ser Asp Ile Glu Ile Ile 
1               5                   10                  15      
Lys Arg Thr Glu Asp Lys Thr Ser Asn Lys Trp Gly Val Thr Gln Asn 
            20                  25                  30          
Ile Gln Phe Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu 
        35                  40                  45              
Ile Leu Lys Met Gln Gly Phe Ile Ser Ser Arg Thr Thr Tyr Tyr Asn 
    50                  55                  60                  
Tyr Lys Lys Thr Asn His Val Lys Ala Met Arg Trp Pro Phe Gln Tyr 
65                  70                  75                  80  
Asn Ile Gly Leu Lys Thr Asn Asp Lys Tyr Val Ser Leu Ile Asn Tyr 
                85                  90                  95      
Leu Pro Lys Asn Lys Ile Glu Ser Thr Asn Val Ser Gln Thr Leu Gly 
            100                 105                 110         
Tyr Asn Ile Gly Gly Asn Phe Gln Ser Ala Pro Ser Leu Gly Gly Asn 
        115                 120                 125             
Gly Ser Phe Asn Tyr Ser Lys Ser Ile Ser Tyr Thr Gln Gln Asn Tyr 
    130                 135                 140                 
Val Ser Glu Val Glu Gln Gln Asn Ser Lys Ser Val Leu Trp Gly Val 
145                 150                 155                 160 
Lys Ala Asn Ser Phe Ala Thr Glu Ser Gly Gln Lys Ser Ala Phe Asp 
                165                 170                 175     
Ser Asp Leu Phe Val Gly Tyr Lys Pro His Ser Lys Asp Pro Arg Asp 
            180                 185                 190         
Tyr Phe Val Pro Asp Ser Glu Leu Pro Pro Leu Val Gln Ser Gly Phe 
        195                 200                 205             
Asn Pro Ser Phe Ile Ala Thr Val Ser His Glu Lys Gly Ser Ser Asp 
    210                 215                 220                 
Thr Ser Glu Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His 
225                 230                 235                 240 
Ala Ile Lys Arg Ser Thr His Tyr Gly Asn Ser Tyr Leu Asp Gly His 
                245                 250                 255     
Arg Val His Asn Ala Phe Val Asn Arg Asn Tyr Thr Val Lys Tyr Glu 
            260                 265                 270         
Val Asn Trp Lys Thr His Glu Ile Lys Val Lys Gly Gln Asn 
        275                 280                 285     

<210> 67
<211> 900
<212> DNA
<213> Staphylococcus aureus

<400> 67
gcggaaggca aaattacccc ggtctcggtg aaaaaagttg acgacaaagt gacgctgtat      60

aaaacgacgg ccacggctga ttcggataaa tttaaaatta gccagatcct gaccttcaac     120

ttcatcaaag ataaatctta cgataaagac accctggtgc tgaaagcaac gggcaacatc     180

aatagcggtt ttgttaaacc gaacccgaat gattacgact tctcaaaact gtattggggc     240

gcaaaataca atgtttcgat tagctctcag agtaacgatt ccgtcaatgt ggttgactat     300

gctccgaaaa accaaaatga agaatttcag gtgcaaaaca ccctgggtta cacgttcggc     360

ggtgatattt caatctcgaa tggcctgagt ggcggtctga acggtaatac cgcgttttcc     420

gaaacgatta actataaaca ggaaagctac cgtaccacgc tgtctcgcaa caccaattat     480

aaaaatgtcg gctggggtgt ggaagcccat aaaatcatga acaatggctg gggtccgtat     540

ggccgtgact cctttcaccc gacgtacggc aacgaactgt tcctggcagg tcgccagagt     600

tccgcatatg caggtcaaaa ttttattgcc cagcatcaaa tgccgctgct gagccgttct     660

aactttaatc cggaattcct gtcagtcctg tcgcaccgcc aggatggcgc gaaaaaatct     720

aaaatcaccg ttacgtacca gcgtgaaatg gacctgtacc aaatccgctg gaacggcttc     780

tattgggcag gtgctaacta caaaaacttc aaaacccgta cgttcaaatc tacctatgaa     840

atcgattggg aaaaccacaa agtcaaactg ctggacacga aagaaacgga aaataataaa     900


<210> 68
<211> 300
<212> PRT
<213> Staphylococcus aureus

<400> 68
Ala Glu Gly Lys Ile Thr Pro Val Ser Val Lys Lys Val Asp Asp Lys 
1               5                   10                  15      
Val Thr Leu Tyr Lys Thr Thr Ala Thr Ala Asp Ser Asp Lys Phe Lys 
            20                  25                  30          
Ile Ser Gln Ile Leu Thr Phe Asn Phe Ile Lys Asp Lys Ser Tyr Asp 
        35                  40                  45              
Lys Asp Thr Leu Val Leu Lys Ala Thr Gly Asn Ile Asn Ser Gly Phe 
    50                  55                  60                  
Val Lys Pro Asn Pro Asn Asp Tyr Asp Phe Ser Lys Leu Tyr Trp Gly 
65                  70                  75                  80  
Ala Lys Tyr Asn Val Ser Ile Ser Ser Gln Ser Asn Asp Ser Val Asn 
                85                  90                  95      
Val Val Asp Tyr Ala Pro Lys Asn Gln Asn Glu Glu Phe Gln Val Gln 
            100                 105                 110         
Asn Thr Leu Gly Tyr Thr Phe Gly Gly Asp Ile Ser Ile Ser Asn Gly 
        115                 120                 125             
Leu Ser Gly Gly Leu Asn Gly Asn Thr Ala Phe Ser Glu Thr Ile Asn 
    130                 135                 140                 
Tyr Lys Gln Glu Ser Tyr Arg Thr Thr Leu Ser Arg Asn Thr Asn Tyr 
145                 150                 155                 160 
Lys Asn Val Gly Trp Gly Val Glu Ala His Lys Ile Met Asn Asn Gly 
                165                 170                 175     
Trp Gly Pro Tyr Gly Arg Asp Ser Phe His Pro Thr Tyr Gly Asn Glu 
            180                 185                 190         
Leu Phe Leu Ala Gly Arg Gln Ser Ser Ala Tyr Ala Gly Gln Asn Phe 
        195                 200                 205             
Ile Ala Gln His Gln Met Pro Leu Leu Ser Arg Ser Asn Phe Asn Pro 
    210                 215                 220                 
Glu Phe Leu Ser Val Leu Ser His Arg Gln Asp Gly Ala Lys Lys Ser 
225                 230                 235                 240 
Lys Ile Thr Val Thr Tyr Gln Arg Glu Met Asp Leu Tyr Gln Ile Arg 
                245                 250                 255     
Trp Asn Gly Phe Tyr Trp Ala Gly Ala Asn Tyr Lys Asn Phe Lys Thr 
            260                 265                 270         
Arg Thr Phe Lys Ser Thr Tyr Glu Ile Asp Trp Glu Asn His Lys Val 
        275                 280                 285             
Lys Leu Leu Asp Thr Lys Glu Thr Glu Asn Asn Lys 
    290                 295                 300 

<210> 69
<211> 972
<212> DNA
<213> Staphylococcus aureus

<400> 69
aactcggctc ataaagatag tcaggatcaa aataaaaaag aacacgtgga taaatcacaa      60

cagaaagata aacgcaatgt caccaataaa gataaaaata gcaccgcacc ggatgacatt     120

ggcaaaaacg gtaaaatcac caaacgtacc gaaacggtgt atgatgaaaa aacgaatatt     180

ctgcagaacc tgcaatttga tttcatcgat gacccgacct acgacaaaaa tgtgctgctg     240

gttaaaaaac agggcagcat tcattctaac ctgaaattcg aaagtcacaa agaagagaaa     300

aactccaact ggctgaaata tccgtcagaa taccatgtcg atttccaggt gaaacgtaat     360

cgcaaaaccg aaattctgga ccaactgccg aaaaacaaaa tcagtaccgc caaagttgat     420

agtacgtttt cctatagctc tggcggtaaa ttcgactcta ccaaaggcat cggtcgtacg     480

agttccaact catactcgaa aaccatctcg tacaaccagc aaaactacga tacgatcgca     540

agcggcaaaa acaataactg gcatgttcac tggtctgtca ttgctaacga tctgaaatat     600

ggcggtgaag ttaaaaatcg caacgacgaa ctgctgtttt accgtaatac ccgcatcgcg     660

acggtcgaaa acccggaact gtcattcgcg tcgaaatatc gttacccggc cctggtgcgc     720

tccggtttta atccggaatt cctgacctac ctgagcaacg aaaaatctaa cgaaaaaacg     780

cagttcgaag tcacctatac gcgtaatcaa gatattctga aaaaccgtcc gggcattcac     840

tacgcaccgc cgatcctgga gaaaaacaaa gatggtcagc gcctgatcgt gacctatgaa     900

gttgactgga aaaacaaaac cgtgaaagtg gtggacaaat actcggacga caataaaccg     960

tacaaagaag gt                                                         972


<210> 70
<211> 324
<212> PRT
<213> Staphylococcus aureus

<400> 70
Asn Ser Ala His Lys Asp Ser Gln Asp Gln Asn Lys Lys Glu His Val 
1               5                   10                  15      
Asp Lys Ser Gln Gln Lys Asp Lys Arg Asn Val Thr Asn Lys Asp Lys 
            20                  25                  30          
Asn Ser Thr Ala Pro Asp Asp Ile Gly Lys Asn Gly Lys Ile Thr Lys 
        35                  40                  45              
Arg Thr Glu Thr Val Tyr Asp Glu Lys Thr Asn Ile Leu Gln Asn Leu 
    50                  55                  60                  
Gln Phe Asp Phe Ile Asp Asp Pro Thr Tyr Asp Lys Asn Val Leu Leu 
65                  70                  75                  80  
Val Lys Lys Gln Gly Ser Ile His Ser Asn Leu Lys Phe Glu Ser His 
                85                  90                  95      
Lys Glu Glu Lys Asn Ser Asn Trp Leu Lys Tyr Pro Ser Glu Tyr His 
            100                 105                 110         
Val Asp Phe Gln Val Lys Arg Asn Arg Lys Thr Glu Ile Leu Asp Gln 
        115                 120                 125             
Leu Pro Lys Asn Lys Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser 
    130                 135                 140                 
Tyr Ser Ser Gly Gly Lys Phe Asp Ser Thr Lys Gly Ile Gly Arg Thr 
145                 150                 155                 160 
Ser Ser Asn Ser Tyr Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr 
                165                 170                 175     
Asp Thr Ile Ala Ser Gly Lys Asn Asn Asn Trp His Val His Trp Ser 
            180                 185                 190         
Val Ile Ala Asn Asp Leu Lys Tyr Gly Gly Glu Val Lys Asn Arg Asn 
        195                 200                 205             
Asp Glu Leu Leu Phe Tyr Arg Asn Thr Arg Ile Ala Thr Val Glu Asn 
    210                 215                 220                 
Pro Glu Leu Ser Phe Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg 
225                 230                 235                 240 
Ser Gly Phe Asn Pro Glu Phe Leu Thr Tyr Leu Ser Asn Glu Lys Ser 
                245                 250                 255     
Asn Glu Lys Thr Gln Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile 
            260                 265                 270         
Leu Lys Asn Arg Pro Gly Ile His Tyr Ala Pro Pro Ile Leu Glu Lys 
        275                 280                 285             
Asn Lys Asp Gly Gln Arg Leu Ile Val Thr Tyr Glu Val Asp Trp Lys 
    290                 295                 300                 
Asn Lys Thr Val Lys Val Val Asp Lys Tyr Ser Asp Asp Asn Lys Pro 
305                 310                 315                 320 
Tyr Lys Glu Gly 
                

<210> 71
<211> 927
<212> DNA
<213> Staphylococcus aureus

<400> 71
aaaatcaaca gcgaaatcaa acaagtcagc gaaaaaaatc tggatggcga tacgaaaatg      60

tacacgcgca cggcaaccac gagcgattcg cagaaaaaca tcacccagag cctgcaattt     120

aatttcctga ccgaaccgaa ctacgataaa gaaacggtgt tcatcaaagc aaaaggcacc     180

atcggctcag gtctgcgtat tctggacccg aatggctact ggaactcgac cctgcgctgg     240

ccgggtagct attctgtgag tattcagaat gttgatgaca acaataacac caacgttacg     300

gattttgctc cgaaaaatca agatgaaagc cgtgaagtca aatataccta cggctataaa     360

acgggcggtg atttctctat caatcgcggc ggtctgaccg gtaatattac gaaagaatcg     420

aactatagcg aaaccatctc ctaccagcaa ccgtcatatc gtaccctgct ggatcagtcc     480

acgtcacata aaggcgttgg ttggaaagtc gaagcgcacc tgatcaataa catgggccat     540

gatcacaccc gtcaactgac gaatgatagc gacaaccgca cgaaatctga aatttttagt     600

ctgacccgca atggtaacct gtgggcgaaa gataacttca cgccgaaaga caaaatgccg     660

gtcaccgtgt ccgaaggctt taatccggaa ttcctggccg ttatgtctca tgataaaaaa     720

gacaaaggta aaagtcagtt cgtggttcac tacaaacgtt ccatggatga attcaaaatc     780

gactggaacc gccatggctt ctggggttac tggagcggtg aaaaccacgt cgataaaaaa     840

gaagaaaaac tgtctgcact gtatgaagtg gactggaaaa cccacaatgt caaattcgtg     900

aaagttctga atgataatga aaaaaaa                                         927


<210> 72
<211> 309
<212> PRT
<213> Staphylococcus aureus

<400> 72
Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp Gly 
1               5                   10                  15      
Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln Lys 
            20                  25                  30          
Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn Tyr 
        35                  40                  45              
Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly 
    50                  55                  60                  
Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg Trp 
65                  70                  75                  80  
Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn Asn 
                85                  90                  95      
Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg Glu 
            100                 105                 110         
Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile Asn 
        115                 120                 125             
Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser Glu 
    130                 135                 140                 
Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln Ser 
145                 150                 155                 160 
Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile Asn 
                165                 170                 175     
Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asn 
            180                 185                 190         
Arg Thr Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp 
        195                 200                 205             
Ala Lys Asp Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val Ser 
    210                 215                 220                 
Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Lys 
225                 230                 235                 240 
Asp Lys Gly Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met Asp 
                245                 250                 255     
Glu Phe Lys Ile Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp Ser 
            260                 265                 270         
Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu Tyr 
        275                 280                 285             
Glu Val Asp Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu Asn 
    290                 295                 300                 
Asp Asn Glu Lys Lys 
305                 

<210> 73
<211> 966
<212> DNA
<213> Staphylococcus aureus

<400> 73
gcaaacaagg actcccagga ccagaccaaa aaagaacacg tcgataaagc acagcagaaa      60

gaaaagcgta atgtcaacga taaagataaa aataccccgg gcccggatga cattggcaaa     120

aacggcaagg ttaccaaacg taccgtcagt gaatatgaca aagaaaccaa tattctgcag     180

aacctgcaat ttgatttcat cgatgacccg acgtacgaca aaaatgtgct gctggttaaa     240

aagcaaggta gtatccattc caacctgaag tttgaaagcc accgtaatga aaccaacgcg     300

agttggctga aatatccgtc cgaataccat gtcgatttcc aggtgcaacg caatccgaaa     360

acggaaattc tggaccagct gccgaaaaac aagatctcaa ccgcaaaagt ggattcgacg     420

tttagttatt ccctgggcgg taaattcgac agcaccaaag gcattggtcg caccagcagc     480

aacagctact cgaagagcat ctcttacaac cagcaaaact acgataccat cgcaagcggc     540

aaaaacaata accgtcatgt tcactggtct gtggttgcta atgatctgaa gtatggtaac     600

gaaatcaaaa atcgcaacga cgaatttctg ttctaccgta atacccgcct gagtacggtc     660

gaaaacccgg aactgtcatt tgcgtcgaaa tatcgttacc cggccctggt tcgctccggc     720

tttaatccgg aatttctgac ctacatcagc aacgaaaagt ctaacgaaaa gacgcgtttc     780

gaagtgacct atacgcgcaa tcaggatatc ctgaaaaaca agccgggcat tcactacggt     840

cagccgatcc tggaacaaaa caaagatggc cagcgtttta ttgtcgtgta tgaagtggac     900

tggaaaaata agaccgttaa ggttgtcgaa aaatattctg atcagaacaa gccgtacaaa     960

gaaggt                                                                966


<210> 74
<211> 322
<212> PRT
<213> Staphylococcus aureus

<400> 74
Ala Asn Lys Asp Ser Gln Asp Gln Thr Lys Lys Glu His Val Asp Lys 
1               5                   10                  15      
Ala Gln Gln Lys Glu Lys Arg Asn Val Asn Asp Lys Asp Lys Asn Thr 
            20                  25                  30          
Pro Gly Pro Asp Asp Ile Gly Lys Asn Gly Lys Val Thr Lys Arg Thr 
        35                  40                  45              
Val Ser Glu Tyr Asp Lys Glu Thr Asn Ile Leu Gln Asn Leu Gln Phe 
    50                  55                  60                  
Asp Phe Ile Asp Asp Pro Thr Tyr Asp Lys Asn Val Leu Leu Val Lys 
65                  70                  75                  80  
Lys Gln Gly Ser Ile His Ser Asn Leu Lys Phe Glu Ser His Arg Asn 
                85                  90                  95      
Glu Thr Asn Ala Ser Trp Leu Lys Tyr Pro Ser Glu Tyr His Val Asp 
            100                 105                 110         
Phe Gln Val Gln Arg Asn Pro Lys Thr Glu Ile Leu Asp Gln Leu Pro 
        115                 120                 125             
Lys Asn Lys Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser Tyr Ser 
    130                 135                 140                 
Leu Gly Gly Lys Phe Asp Ser Thr Lys Gly Ile Gly Arg Thr Ser Ser 
145                 150                 155                 160 
Asn Ser Tyr Ser Lys Ser Ile Ser Tyr Asn Gln Gln Asn Tyr Asp Thr 
                165                 170                 175     
Ile Ala Ser Gly Lys Asn Asn Asn Arg His Val His Trp Ser Val Val 
            180                 185                 190         
Ala Asn Asp Leu Lys Tyr Gly Asn Glu Ile Lys Asn Arg Asn Asp Glu 
        195                 200                 205             
Phe Leu Phe Tyr Arg Asn Thr Arg Leu Ser Thr Val Glu Asn Pro Glu 
    210                 215                 220                 
Leu Ser Phe Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg Ser Gly 
225                 230                 235                 240 
Phe Asn Pro Glu Phe Leu Thr Tyr Ile Ser Asn Glu Lys Ser Asn Glu 
                245                 250                 255     
Lys Thr Arg Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile Leu Lys 
            260                 265                 270         
Asn Lys Pro Gly Ile His Tyr Gly Gln Pro Ile Leu Glu Gln Asn Lys 
        275                 280                 285             
Asp Gly Gln Arg Phe Ile Val Val Tyr Glu Val Asp Trp Lys Asn Lys 
    290                 295                 300                 
Thr Val Lys Val Val Glu Lys Tyr Ser Asp Gln Asn Lys Pro Tyr Lys 
305                 310                 315                 320 
Glu Gly 
        

<210> 75
<211> 945
<212> DNA
<213> Staphylococcus aureus

<400> 75
gcaagctcgt atgcggaaat caaaagcaag atcaccaccg tctcagaaaa gaacctggat      60

ggcgacacca agatgtacac ccgtaccgcg accacgagcg atacggaaaa gaaaattagc     120

cagtctctgc aatttaattt cctgaccgaa ccgaactacg acaaagaaac ggtgtttatt     180

aaagccaagg gcaccatcgg cagcggtctg aaaattctga atccgaacgg ctactggaac     240

agcaccctgc gttggccggg tagttattcc gtttcaattc agaacgtcga tgacaacaat     300

aactcaacca atgtcacgga ttttgcaccg aaaaaccaag acgaatcgcg tgaagtgaaa     360

tatacctacg gctataagac gggcggtgat ttcagtatca atcgcggcgg tctgaccggt     420

aacatcacga aggaaaagaa ctactcggaa accatcagct accagcaacc gtcttatcgt     480

accctgattg atcagccgac cacgaataaa ggcgtcgcgt ggaaggtgga agcccatagc     540

atcaataaca tgggtcatga tcacacccgt caactgacga acgactctga tgaccgcgtg     600

aaatctgaaa tttttagtct gacccgcaat ggcaacctgt gggcaaaaga taatttcacg     660

ccgaaaaaca agatgccggt gaccgtttcc gaaggcttta atccggaatt tctggctgtt     720

atgtcccatg ataaaaacga caaaggtaag tcacgtttca tcgtccacta taaacgctcg     780

atggatgact ttaaactgga ttggaataag catggcttct ggggttactg gagtggtgaa     840

aaccacgttg accagaaaga agaaaagctg tccgccctgt atgaagtgga ttggaaaacg     900

cacgacgtta aactgattaa gaccatcaac gataaagaac agaag                     945


<210> 76
<211> 315
<212> PRT
<213> Staphylococcus aureus

<400> 76
Ala Ser Ser Tyr Ala Glu Ile Lys Ser Lys Ile Thr Thr Val Ser Glu 
1               5                   10                  15      
Lys Asn Leu Asp Gly Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr 
            20                  25                  30          
Ser Asp Thr Glu Lys Lys Ile Ser Gln Ser Leu Gln Phe Asn Phe Leu 
        35                  40                  45              
Thr Glu Pro Asn Tyr Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly 
    50                  55                  60                  
Thr Ile Gly Ser Gly Leu Lys Ile Leu Asn Pro Asn Gly Tyr Trp Asn 
65                  70                  75                  80  
Ser Thr Leu Arg Trp Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val 
                85                  90                  95      
Asp Asp Asn Asn Asn Ser Thr Asn Val Thr Asp Phe Ala Pro Lys Asn 
            100                 105                 110         
Gln Asp Glu Ser Arg Glu Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly 
        115                 120                 125             
Gly Asp Phe Ser Ile Asn Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys 
    130                 135                 140                 
Glu Lys Asn Tyr Ser Glu Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg 
145                 150                 155                 160 
Thr Leu Ile Asp Gln Pro Thr Thr Asn Lys Gly Val Ala Trp Lys Val 
                165                 170                 175     
Glu Ala His Ser Ile Asn Asn Met Gly His Asp His Thr Arg Gln Leu 
            180                 185                 190         
Thr Asn Asp Ser Asp Asp Arg Val Lys Ser Glu Ile Phe Ser Leu Thr 
        195                 200                 205             
Arg Asn Gly Asn Leu Trp Ala Lys Asp Asn Phe Thr Pro Lys Asn Lys 
    210                 215                 220                 
Met Pro Val Thr Val Ser Glu Gly Phe Asn Pro Glu Phe Leu Ala Val 
225                 230                 235                 240 
Met Ser His Asp Lys Asn Asp Lys Gly Lys Ser Arg Phe Ile Val His 
                245                 250                 255     
Tyr Lys Arg Ser Met Asp Asp Phe Lys Leu Asp Trp Asn Lys His Gly 
            260                 265                 270         
Phe Trp Gly Tyr Trp Ser Gly Glu Asn His Val Asp Gln Lys Glu Glu 
        275                 280                 285             
Lys Leu Ser Ala Leu Tyr Glu Val Asp Trp Lys Thr His Asp Val Lys 
    290                 295                 300                 
Leu Ile Lys Thr Ile Asn Asp Lys Glu Gln Lys 
305                 310                 315 

<210> 77
<211> 954
<212> DNA
<213> Staphylococcus aureus

<400> 77
gactcacagg accaaaacaa aaaggaacac gttgataagg cacagcagaa agacaagcaa      60

gatagcacca agaaaggcaa aaacgttgcg gccccggatg acgtcggcaa aaacggcaag     120

gtgaccaaac gtacggaaag cgaatacgat gaaaagacca acatcctgca gaacctggaa     180

tttaatttca tcgatgaccc gacctacgat aaagacgtcc tgctggtgaa aaagcaaggc     240

agtattcatt ccaacctgaa gttcgaaagt cacaaagaag aaaagaacag cacctggctg     300

aaatatccgt cagaatacca tgttgatttc caggtcaagc gtaacccgaa aaccgaaatt     360

ctggaccaac tgccgaaaaa taagatcagt acggcaaaag tggattcaac cttttcgtat     420

acgctgggcg gtaaattcga ctccattaaa ggcatcggtc gcaatagctc taacagctat     480

tctcagacca tttcgtataa tcagcaaaac tacgatacga tcgcgagcgg caaaaacaat     540

aactggcatg tgcactggtc tgttattgcc aacgatctga agtatggcgg tgaagttaaa     600

aatcgtaacg acgaatttct gttctaccgt aacacccgca cgagttccgt tgataatccg     660

gaatcatcgt ttgcagctaa atatcgttac ccggcactgg tccgcagtgg ttttaatccg     720

gaatttctga cctatctgag caacgaaaag tctaatgaaa aaacgcagtt tgaagtgacc     780

tatacgcgta accaagatat cctgaaaaat agcccgggcc tgcattacgc tccgccgatt     840

ctggaaaaga acaaggttgg tcaccgcttt atcgtcacct atgaagtgga ttggaaaaat     900

aagacggtga aggtggttga caaatactct gatgaccagc cgttccgcga aggt           954


<210> 78
<211> 318
<212> PRT
<213> Staphylococcus aureus

<400> 78
Asp Ser Gln Asp Gln Asn Lys Lys Glu His Val Asp Lys Ala Gln Gln 
1               5                   10                  15      
Lys Asp Lys Gln Asp Ser Thr Lys Lys Gly Lys Asn Val Ala Ala Pro 
            20                  25                  30          
Asp Asp Val Gly Lys Asn Gly Lys Val Thr Lys Arg Thr Glu Ser Glu 
        35                  40                  45              
Tyr Asp Glu Lys Thr Asn Ile Leu Gln Asn Leu Glu Phe Asn Phe Ile 
    50                  55                  60                  
Asp Asp Pro Thr Tyr Asp Lys Asp Val Leu Leu Val Lys Lys Gln Gly 
65                  70                  75                  80  
Ser Ile His Ser Asn Leu Lys Phe Glu Ser His Lys Glu Glu Lys Asn 
                85                  90                  95      
Ser Thr Trp Leu Lys Tyr Pro Ser Glu Tyr His Val Asp Phe Gln Val 
            100                 105                 110         
Lys Arg Asn Pro Lys Thr Glu Ile Leu Asp Gln Leu Pro Lys Asn Lys 
        115                 120                 125             
Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser Tyr Thr Leu Gly Gly 
    130                 135                 140                 
Lys Phe Asp Ser Ile Lys Gly Ile Gly Arg Asn Ser Ser Asn Ser Tyr 
145                 150                 155                 160 
Ser Gln Thr Ile Ser Tyr Asn Gln Gln Asn Tyr Asp Thr Ile Ala Ser 
                165                 170                 175     
Gly Lys Asn Asn Asn Trp His Val His Trp Ser Val Ile Ala Asn Asp 
            180                 185                 190         
Leu Lys Tyr Gly Gly Glu Val Lys Asn Arg Asn Asp Glu Phe Leu Phe 
        195                 200                 205             
Tyr Arg Asn Thr Arg Thr Ser Ser Val Asp Asn Pro Glu Ser Ser Phe 
    210                 215                 220                 
Ala Ala Lys Tyr Arg Tyr Pro Ala Leu Val Arg Ser Gly Phe Asn Pro 
225                 230                 235                 240 
Glu Phe Leu Thr Tyr Leu Ser Asn Glu Lys Ser Asn Glu Lys Thr Gln 
                245                 250                 255     
Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile Leu Lys Asn Ser Pro 
            260                 265                 270         
Gly Leu His Tyr Ala Pro Pro Ile Leu Glu Lys Asn Lys Val Gly His 
        275                 280                 285             
Arg Phe Ile Val Thr Tyr Glu Val Asp Trp Lys Asn Lys Thr Val Lys 
    290                 295                 300                 
Val Val Asp Lys Tyr Ser Asp Asp Gln Pro Phe Arg Glu Gly 
305                 310                 315             

<210> 79
<211> 927
<212> DNA
<213> Staphylococcus aureus

<400> 79
aaaatcaaat cggaaatcac gcaagttagc gaacagaata tcgacggcaa tacgaagatg      60

tttacccgca cggcaacgac ctcggatagc cagaaaaaga tcagccagtc tctgcaattt     120

aacttcctga ccgaaccgaa ctacgacaag gaaacggtgt tcatcaaggc aaagggcacc     180

atcggctctg gtctgaaaat tctggacccg aacggctact ggaatagtac cctgcgttgg     240

ccgggtagtt attccgtgtc aatccagaac gttgataaca ataccaatac gaaggttacg     300

gattttgccc cgaaaaacca agacgaaacc cgcgaagtca agtataccta cggctataaa     360

acgggcggtg atttctcgat tagcccgggc ggtattaccg gtaacatcac gaaagaacgt     420

aattattctg aaaccatcag ttaccagcaa ccgagttatc gcaccctgat tgaccagccg     480

gcgacgaata agggcgttgg ttggaaagtc gaagcccatc tgatcaacaa tatgggccat     540

gatcacaccc gtcaactgac gaacgattcc gacaatcgcg tgggctcaga aatttttacc     600

ctgacgcgta acggtaatct gtgggcgaaa gataacttca cgccgaaaaa taagatgccg     660

gtcaccgtgt ccgaaggctt taacccggaa tttctggccg ttatgtcgca tgataaaaag     720

gacaaaggca agagcaaatt tgtggttcac tataaacgta cgatggatga ctttaaaatc     780

gattggatgc gccatggctt ctggggttac tggaccggta aaaatcacgt tgaccagaag     840

gaagaaaaac tgtctgcact gtatgaagtc gattggaaaa cccacgacgt gaagttcatt     900

aaagctctgg atgacaaaga aaagaaa                                         927


<210> 80
<211> 309
<212> PRT
<213> Staphylococcus aureus

<400> 80
Lys Ile Lys Ser Glu Ile Thr Gln Val Ser Glu Gln Asn Ile Asp Gly 
1               5                   10                  15      
Asn Thr Lys Met Phe Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln Lys 
            20                  25                  30          
Lys Ile Ser Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn Tyr 
        35                  40                  45              
Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly 
    50                  55                  60                  
Leu Lys Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg Trp 
65                  70                  75                  80  
Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asn Asn Thr Asn 
                85                  90                  95      
Thr Lys Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Thr Arg Glu 
            100                 105                 110         
Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile Ser 
        115                 120                 125             
Pro Gly Gly Ile Thr Gly Asn Ile Thr Lys Glu Arg Asn Tyr Ser Glu 
    130                 135                 140                 
Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Ile Asp Gln Pro 
145                 150                 155                 160 
Ala Thr Asn Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile Asn 
                165                 170                 175     
Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asn 
            180                 185                 190         
Arg Val Gly Ser Glu Ile Phe Thr Leu Thr Arg Asn Gly Asn Leu Trp 
        195                 200                 205             
Ala Lys Asp Asn Phe Thr Pro Lys Asn Lys Met Pro Val Thr Val Ser 
    210                 215                 220                 
Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Lys 
225                 230                 235                 240 
Asp Lys Gly Lys Ser Lys Phe Val Val His Tyr Lys Arg Thr Met Asp 
                245                 250                 255     
Asp Phe Lys Ile Asp Trp Met Arg His Gly Phe Trp Gly Tyr Trp Thr 
            260                 265                 270         
Gly Lys Asn His Val Asp Gln Lys Glu Glu Lys Leu Ser Ala Leu Tyr 
        275                 280                 285             
Glu Val Asp Trp Lys Thr His Asp Val Lys Phe Ile Lys Ala Leu Asp 
    290                 295                 300                 
Asp Lys Glu Lys Lys 
305                 

<210> 81
<211> 966
<212> DNA
<213> Staphylococcus aureus

<400> 81
gccaacaagg acagccagga ccaaaccaag aaggagcacg tggacaaggc ccagcaaaag      60

gagaagcgca acgtgaacga caaggataag aacacacctg gcccggatga tatcggcaag     120

aacggtaagg tgaccaagcg cacagagacc gtttacgacg agaagaccaa catcctgcag     180

aacctgcagt tcgacttcat cgacgacccg acctacgaca agaacatcct gttagtgaaa     240

aagcagggca gcatccacag caacctgaag ttcgaaagcc acaaagagga gaacaacagc     300

agctggctga aataccctag cgagtaccac gtggatttcc aggtgaagcg caaccgtaag     360

accgagatcc tggaccagct gccgaagaac aagatcagta ccgcaaaggt ggacagcacc     420

ttcagttaca acagcggcgg caagtttgat agtgttaagg gcgttggccg cacaagtagc     480

aacagctaca gcaagacaat tagttataac cagcagaact atgacacaat cgccagcggc     540

aagaacaaca actggcacgt gcattggagc gtggtggcaa atgacctgaa atacggcggc     600

gaggtgaaaa atcgcaacga cgagttcctg ttttaccgca caacccgcct gagcaccgtg     660

gagaaccctg agctgagctt tgccagcaag tatcgctatc cggcactggt gcgtagcggc     720

ttcaacccgg agttcctgac ctacctgagt aacgagaaga gcaatgagaa aacacagttc     780

gaggtgacct acacccgcaa ccaggacatc ctgaagaaca aaccgggcat ccactatgcc     840

ccgccgatcc tggagaagaa taaggacggc cagcgcctga ttgtgaccta cgaggtggac     900

tggaagaaca aaaccgtgaa ggtgatcgac aaatacagcg acgacaacaa gccgtataaa     960

gagggg                                                                966


<210> 82
<211> 322
<212> PRT
<213> Staphylococcus aureus

<400> 82
Ala Asn Lys Asp Ser Gln Asp Gln Thr Lys Lys Glu His Val Asp Lys 
1               5                   10                  15      
Ala Gln Gln Lys Glu Lys Arg Asn Val Asn Asp Lys Asp Lys Asn Thr 
            20                  25                  30          
Pro Gly Pro Asp Asp Ile Gly Lys Asn Gly Lys Val Thr Lys Arg Thr 
        35                  40                  45              
Glu Thr Val Tyr Asp Glu Lys Thr Asn Ile Leu Gln Asn Leu Gln Phe 
    50                  55                  60                  
Asp Phe Ile Asp Asp Pro Thr Tyr Asp Lys Asn Ile Leu Leu Val Lys 
65                  70                  75                  80  
Lys Gln Gly Ser Ile His Ser Asn Leu Lys Phe Glu Ser His Lys Glu 
                85                  90                  95      
Glu Asn Asn Ser Ser Trp Leu Lys Tyr Pro Ser Glu Tyr His Val Asp 
            100                 105                 110         
Phe Gln Val Lys Arg Asn Arg Lys Thr Glu Ile Leu Asp Gln Leu Pro 
        115                 120                 125             
Lys Asn Lys Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser Tyr Asn 
    130                 135                 140                 
Ser Gly Gly Lys Phe Asp Ser Val Lys Gly Val Gly Arg Thr Ser Ser 
145                 150                 155                 160 
Asn Ser Tyr Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr Asp Thr 
                165                 170                 175     
Ile Ala Ser Gly Lys Asn Asn Asn Trp His Val His Trp Ser Val Val 
            180                 185                 190         
Ala Asn Asp Leu Lys Tyr Gly Gly Glu Val Lys Asn Arg Asn Asp Glu 
        195                 200                 205             
Phe Leu Phe Tyr Arg Thr Thr Arg Leu Ser Thr Val Glu Asn Pro Glu 
    210                 215                 220                 
Leu Ser Phe Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg Ser Gly 
225                 230                 235                 240 
Phe Asn Pro Glu Phe Leu Thr Tyr Leu Ser Asn Glu Lys Ser Asn Glu 
                245                 250                 255     
Lys Thr Gln Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile Leu Lys 
            260                 265                 270         
Asn Lys Pro Gly Ile His Tyr Ala Pro Pro Ile Leu Glu Lys Asn Lys 
        275                 280                 285             
Asp Gly Gln Arg Leu Ile Val Thr Tyr Glu Val Asp Trp Lys Asn Lys 
    290                 295                 300                 
Thr Val Lys Val Ile Asp Lys Tyr Ser Asp Asp Asn Lys Pro Tyr Lys 
305                 310                 315                 320 
Glu Gly 
        

<210> 83
<211> 921
<212> DNA
<213> Staphylococcus aureus

<400> 83
aacagcgaga tcaagcaggt gagcgagaaa aacctggacg gcgagaccaa gatgtacaca      60

cgcacagcca ccaccagcga cagccagaaa aacatcaccc agagtctgca gttcaacttc     120

ctgaccgaga agaactatga caaagaaacc gttttcatca aggccaaagg caccatcggc     180

agtggtctgc gcattctgga gccgaacggc tactggaaca gcaccttacg ttggcctggt     240

agttacagcg tgagcatcca gaatgtggac gacaacaaca acaccaacgt gaccgacttc     300

gcaccgaaga atcaggacga gagccgcgag gtgaagtaca cctacggcta caagaccggc     360

ggtgacttta gcatcaacca gggtggcctg accggcaaca tcaccaagga gagcaactac     420

agcgagacca tcagctatca gcaaccgagt taccgcacac tgattgacca gccgacaacc     480

aacaagggcg ttgcctggaa agtggaggcc cacctgatca acaacatggg ccatgaccac     540

acacgtcagc tgaccaacga tagcgatgac cgtgtgaaga gcgagatctt cagcctgacc     600

cgcaacggta atctgtgggc caaggacaac ttcaccccga aaaacaagat gccggtgacc     660

gttagcgaag gcttcaatcc ggagttcctg gccgttatga gccacgacaa gaaggacgag     720

ggcaagagta agttcgtggt gcactacaag cgcagcatgg acgagttcaa gattgactgg     780

aacaagcacg gcttctgggg ctactggagc ggcgagaacc acgtggacaa gaaagaggag     840

aagctgagcg cactgtacga agtggactgg aagacccata acgtgaagtt tattaaggtt     900

ttaaacgata aagagaaaaa a                                               921


<210> 84
<211> 307
<212> PRT
<213> Staphylococcus aureus

<400> 84
Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp Gly Glu Thr 
1               5                   10                  15      
Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln Lys Asn Ile 
            20                  25                  30          
Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Lys Asn Tyr Asp Lys 
        35                  40                  45              
Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly Leu Arg 
    50                  55                  60                  
Ile Leu Glu Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg Trp Pro Gly 
65                  70                  75                  80  
Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn Asn Thr Asn 
                85                  90                  95      
Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg Glu Val Lys 
            100                 105                 110         
Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile Asn Gln Gly 
        115                 120                 125             
Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser Glu Thr Ile 
    130                 135                 140                 
Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Ile Asp Gln Pro Thr Thr 
145                 150                 155                 160 
Asn Lys Gly Val Ala Trp Lys Val Glu Ala His Leu Ile Asn Asn Met 
                165                 170                 175     
Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asp Arg Val 
            180                 185                 190         
Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp Ala Lys 
        195                 200                 205             
Asp Asn Phe Thr Pro Lys Asn Lys Met Pro Val Thr Val Ser Glu Gly 
    210                 215                 220                 
Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Lys Asp Glu 
225                 230                 235                 240 
Gly Lys Ser Lys Phe Val Val His Tyr Lys Arg Ser Met Asp Glu Phe 
                245                 250                 255     
Lys Ile Asp Trp Asn Lys His Gly Phe Trp Gly Tyr Trp Ser Gly Glu 
            260                 265                 270         
Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu Tyr Glu Val 
        275                 280                 285             
Asp Trp Lys Thr His Asn Val Lys Phe Ile Lys Val Leu Asn Asp Lys 
    290                 295                 300                 
Glu Lys Lys 
305         

<210> 85
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 85
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
            20                  25      

<210> 86
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 86
Gly Ser Ile Val Asn Gly Met Tyr Tyr Trp Ser 
1               5                   10      

<210> 87
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 87
Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  

<210> 88
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 88
Asn Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      



<210> 89
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 89
Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      
Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
            20                  25                  30  

<210> 90
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 90
Ala Arg Asp Val Gly Arg Trp Phe Gly Asn Ile 
1               5                   10      

<210> 91
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 91
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      

<210> 92
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 92
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys 
            20              

<210> 93
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 93
Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      

<210> 94
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 94
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  

<210> 95
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 95
Asp Ala Ser Asn Arg Ala Thr 
1               5           

<210> 96
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 96
Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      
Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          



<210> 97
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 97
Gln Gln Arg Tyr Val Met Pro Pro Thr 
1               5                   

<210> 98
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 98
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  

<210> 99
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 99
Gly Ser Ile Ser Ser Gly Gly Tyr Tyr Trp Ser 
1               5                   10      

<210> 100
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 100
Asp Ser Ser Asn Arg Ala Thr 
1               5           

<210> 101
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 101
Gln Gln Arg Phe Asn Met Pro Pro Thr 
1               5                   

<210> 102
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 102
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys 
            20              

<210> 103
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 103
Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      

<210> 104
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 104
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  

<210> 105
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 105
Asp Ser Ser Asn Arg Ala Thr 
1               5           

<210> 106
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 106
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      
Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
            20                  25                  30          



<210> 107
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 107
Gln Gln Tyr Asp Tyr Leu Pro Pro Thr 
1               5                   

<210> 108
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 108
Gln Gln Val Tyr Asp Leu Pro Pro Thr 
1               5                   

<210> 109
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 109
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
            20                  25      

<210> 110
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 110
Gly Thr Phe Ser Ala Tyr Glu Ile Ser 
1               5                   

<210> 111
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 111
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  

<210> 112
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 112
Ser Ile Ile Pro Ile Phe Gly Arg Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 113
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 113
Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      
Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
            20                  25                  30  

<210> 114
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 114
Ala Arg Asp Ala Gly Cys Ser Ser Thr Ser Cys His Lys Asp Val Tyr 
1               5                   10                  15      
Phe Asp Tyr 
            

<210> 115
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 115
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      

<210> 116
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 116
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      

<210> 117
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 117
Gly Ala Ser Ser Leu Gln Ser 
1               5           

<210> 118
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 118
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          



<210> 119
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 119
Gln Gln Ala Tyr Tyr Pro Pro Trp Thr 
1               5                   

<210> 120
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 120
Gly Thr Phe Ser Ser Tyr Ser Ile Ser 
1               5                   

<210> 121
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 121
Ser Ile Ile Pro Ile Phe Gly Phe Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 122
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 122
Gly Thr Phe Ser Ser Tyr Ala Ile Ser 
1               5                   

<210> 123
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 123
Val Ile Glu Pro Ile Phe Gly Phe Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 124
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 124
Ser Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 125
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 125
Ala Ala Ser Ser Leu Gln Ser 
1               5           

<210> 126
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 126
Gln Gln Ala Tyr Thr Pro Pro Trp Thr 
1               5                   

<210> 127
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 127
Gln Gln Ala Tyr Thr Pro Pro Trp Thr 
1               5                   

<210> 128
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 128
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys 
            20              

<210> 129
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 129
Gln Gln Ser Tyr Tyr Pro Pro Trp Thr 
1               5                   

<210> 130
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 130
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            20                  25      

<210> 131
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 131
Phe Thr Phe Tyr Asp Tyr Asn Met His 
1               5                   

<210> 132
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 132
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  

<210> 133
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 133
Gly Ile Ser Trp Asn Ser Gly Ser Ile Ala Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 134
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 134
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
1               5                   10                  15      
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
            20                  25                  30  

<210> 135
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 135
Ala Lys Ala Gln Lys Gly Thr Ala Phe Asp Ile 
1               5                   10      

<210> 136
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 136
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      

<210> 137
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 137
Gln Ala Ser Gln Asp Ile Thr Asn Tyr Leu Asn 
1               5                   10      

<210> 138
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 138
Gln Gln Tyr Pro Val Tyr Pro Pro Thr 
1               5                   

<210> 139
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 139
Phe Thr Phe Ala Asp Tyr Asn Met His 
1               5                   

<210> 140
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 140
Gly Ile Ser Trp Asn Ser Gly Leu Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 141
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 141
Phe Thr Phe Gly Asp Tyr Asn Met His 
1               5                   

<210> 142
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 142
Gly Ile Ser Trp Asn Ser Gly Met Ser Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 143
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 143
Phe Thr Phe Asp Leu Phe Ala Met His 
1               5                   

<210> 144
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 144
Gly Ile Thr Trp Asn Ser Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 145
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 145
Phe Thr Phe Ala Glu Tyr Ala Met His 
1               5                   

<210> 146
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 146
Gly Ile Thr Trp Asn Ser Gly Ser Ile Ala Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 147
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 147
Phe Thr Phe Asp Ser Tyr Asn Met His 
1               5                   

<210> 148
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 148
Phe Thr Phe Asp Asp Tyr Ala Met His 
1               5                   

<210> 149
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 149
Gly Ile Ser Trp Asn Ser Gly Ala Ile Ala Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 150
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 150
Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 151
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 151
Gln Ala Ser Gln Asp Ile Ala Asn Tyr Leu Asn 
1               5                   10      

<210> 152
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 152
Gln Gln Tyr Pro Thr Tyr Pro Pro Thr 
1               5                   

<210> 153
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 153
Gln Gln Tyr Pro Ile Tyr Pro Pro Thr 
1               5                   

<210> 154
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 154
Gln Gln Leu Pro Tyr Leu Pro Phe Thr 
1               5                   

<210> 155
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 155
Gly Ser Ile Ser Ser Gly Trp Tyr Tyr Trp Ser 
1               5                   10      

<210> 156
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 156
Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      



<210> 157
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 157
Ala Arg Glu Arg Gly Met His Tyr Met Asp Val 
1               5                   10      

<210> 158
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 158
Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      

<210> 159
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 159
Arg Ala Ser Gln Ser Ile Asn Ser Tyr Leu Asn 
1               5                   10      

<210> 160
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 160
Gln Gln Gln Phe Asp Pro Pro Phe Thr 
1               5                   

<210> 161
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 161
Gly Ser Ile Ser Ser Gly His Tyr Tyr Trp Gly 
1               5                   10      

<210> 162
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 162
Asn Ile Tyr Gly Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      



<210> 163
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 163
Gly Ser Ile Glu Ser Gly Phe Tyr Tyr Trp Ser 
1               5                   10      

<210> 164
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 164
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
            20                  25      

<210> 165
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 165
Gly Ser Ile Ser Ser Ser Gly Tyr Tyr Trp Val 
1               5                   10      

<210> 166
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 166
Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  

<210> 167
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 167
Gly Ser Ile Ser Ser Gly Ser Tyr Tyr Trp Asp 
1               5                   10      

<210> 168
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 168
Asn Ile Tyr Lys Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      



<210> 169
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 169
Gly Ser Ile Ser Ser Ser Ser Tyr Tyr Trp Gly 
1               5                   10      

<210> 170
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 170
Gln Gln Gln Tyr Leu Pro Pro Phe Thr 
1               5                   

<210> 171
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 171
Gly Thr Phe Trp Ser Gly Ala Ile Ser 
1               5                   

<210> 172
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 172
Gly Ile Ile Pro Ile Glu Gly Pro Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 173
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 173
Ala Arg Gly Ile Val Ala Ala Asp His Leu Tyr Phe Asp Leu 
1               5                   10                  

<210> 174
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 174
Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      

<210> 175
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 175
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys 
            20              

<210> 176
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 176
Arg Ser Ser Gln Ser Leu Leu Tyr Ser Asn Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      



<210> 177
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 177
Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr 
1               5                   10                  15  

<210> 178
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 178
Leu Gly Ser Asn Arg Ala Ser 
1               5           

<210> 179
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 179
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      
Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          



<210> 180
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 180
Met Gln Ala Leu Gln Gly Leu Thr 
1               5               

<210> 181
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 181
Gly Thr Phe Ser Leu Tyr Ala Ile Ser 
1               5                   

<210> 182
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 182
Gly Ile Ile Pro Ile Asp Gly Pro Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 183
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 183
Gly Thr Phe Trp Glu Tyr Ala Ile Ser 
1               5                   

<210> 184
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 184
Gly Ile Ile Pro Ile Glu Gly Asp Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 185
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 185
Gly Thr Phe Ser Asn Tyr Ala Ile Ser 
1               5                   

<210> 186
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 186
Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 187
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 187
Met Gln Ala Lys Gln Gly Leu Thr 
1               5               

<210> 188
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 188
Gly Thr Phe Ser Ser Trp Ala Ile Ser 
1               5                   

<210> 189
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 189
Gly Ile Ile Pro Ile Phe Gly Glu Ala Ala Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 190
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 190
Ala Arg Ala Arg Glu Gly Asp Asp Pro Tyr Gly Met Asp Val 
1               5                   10                  

<210> 191
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 191
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      

<210> 192
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 192
Met Gln Ala Lys Arg Leu Phe Thr 
1               5               

<210> 193
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 193
Gly Ile Ile Pro Ile Phe Gly Pro Ala Ala Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 194
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 194
Gly Thr Phe Ser Asn Trp Ala Ile Ser 
1               5                   

<210> 195
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 195
Gly Ile Ile Pro Ile Phe Gly Ser Ala Ala Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 196
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 196
Gly Thr Phe Gly Ser Met Ala Ile Ser 
1               5                   

<210> 197
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 197
Gly Ile Ile Pro Ile Phe Gly Pro Ala Val Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 198
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 198
Gly Thr Ile Trp Ser Glu Ala Ile Ser 
1               5                   

<210> 199
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 199
Gly Ile Ile Pro Ile Phe Gly Asp Ala Val Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 200
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 200
Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      



<210> 201
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 201
Leu Ala Ser Asn Arg Ala Ser 
1               5           

<210> 202
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 202
Met Gln Ala Arg Arg Leu Phe Thr 
1               5               

<210> 203
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 203
Gly Thr Phe Lys Ser Trp Ala Ile Ser 
1               5                   

<210> 204
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 204
Gly Thr Phe Trp Ser Trp Ala Ile Ser 
1               5                   

<210> 205
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 205
Gly Ile Ile Pro Thr Phe Gly Glu Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 206
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 206
Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Phe 
1               5                   10                  15  

<210> 207
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 207
Met Gln Ala Arg Gln Leu Phe Thr 
1               5               

<210> 208
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 208
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly 
            20                  25      

<210> 209
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 209
Tyr Ser Ile Ser Ser Gly Tyr Tyr Trp Gly 
1               5                   10  

<210> 210
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 210
Thr Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      



<210> 211
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 211
Ala Arg Thr Trp Ser Ser Met Asp Val 
1               5                   

<210> 212
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 212
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      

<210> 213
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 213
Gln Gln Ile Tyr Leu His Pro Ile Thr 
1               5                   

<210> 214
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 214
Gln Gln Ile Tyr Ser His Pro Ile Thr 
1               5                   

<210> 215
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 215
Gln Gln Ile Phe Ser His Pro Ile Thr 
1               5                   

<210> 216
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 216
Gln Gln Val Tyr Ser His Pro Ile Thr 
1               5                   

<210> 217
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 217
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            20                  25      

<210> 218
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 218
Phe Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   

<210> 219
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 219
Gly Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 220
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 220
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
            20                  25                  30  

<210> 221
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 221
Ala Lys Ser Leu Arg Tyr Gly Tyr Ala Phe Asp Leu 
1               5                   10          

<210> 222
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 222
Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      

<210> 223
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 223
Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Val Leu Ile Tyr 
1               5                   10                  15  

<210> 224
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 224
Met Gln Ala Lys Gln Gly Ile Thr 
1               5               

<210> 225
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 225
Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr 
1               5                   10                  15  

<210> 226
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 226
Met Gln Ala Arg Gln Gly Ile Thr 
1               5               

<210> 227
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR sequence

<400> 227
Met Gln Ala Arg Gln Gly Leu Thr 
1               5               

<210> 228
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 228
Glu Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
            20                  25      

<210> 229
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 229
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
            20                  25      

<210> 230
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> Framework sequence

<400> 230
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
            20                  25      

<210> 231
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain sequence

<400> 231
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Val Asn Gly 
            20                  25                  30          
Met Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              
Trp Ile Gly Asn Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Asp Val Gly Arg Trp Phe Gly Asn Ile Trp Gly Gln Gly 
            100                 105                 110         
Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             
Lys 
    

<210> 232
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain sequence

<400> 232
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Tyr Val Met Pro Pro 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210> 233
<211> 456
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain sequence

<400> 233
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ala Tyr 
            20                  25                  30          
Glu Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ser Ile Ile Pro Ile Phe Gly Arg Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Ala Gly Cys Ser Ser Thr Ser Cys His Lys Asp Val Tyr 
            100                 105                 110         
Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             
Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     

<210> 234
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain sequence

<400> 234
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr Tyr Pro Pro Trp 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210> 235
<211> 456
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain sequence

<400> 235
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Val Ile Glu Pro Ile Phe Gly Phe Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Ala Gly Cys Ser Ser Thr Ser Cys His Lys Asp Val Tyr 
            100                 105                 110         
Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             
Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     

<210> 236
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain sequence

<400> 236
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr Tyr Pro Pro Trp 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210> 237
<211> 456
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain sequence

<400> 237
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Val Ile Glu Pro Ile Phe Gly Phe Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Ala Gly Cys Ser Ser Thr Ser Cys His Lys Asp Val Tyr 
            100                 105                 110         
Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             
Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     

<210> 238
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain sequence

<400> 238
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr Tyr Pro Pro Trp 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210> 239
<211> 448
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain sequence

<400> 239
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Tyr Asp Tyr 
            20                  25                  30          
Asn Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Ala Gln Lys Gly Thr Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         
Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             



<210> 240
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain sequence

<400> 240
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Thr Asn Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Pro Val Tyr Pro Pro 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210> 241
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain sequence

<400> 241
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          
Trp Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              
Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Glu Arg Gly Met His Tyr Met Asp Val Trp Gly Lys Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             
Lys 
    

<210> 242
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain sequence

<400> 242
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gln Phe Asp Pro Pro Phe 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210> 243
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain sequence

<400> 243
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          
Ser Tyr Tyr Trp Asp Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              
Trp Ile Gly Asn Ile Tyr Lys Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Glu Arg Gly Met His Tyr Met Asp Val Trp Gly Lys Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             
Lys 
    

<210> 244
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain sequence

<400> 244
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gln Phe Asp Pro Pro Phe 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210> 245
<211> 448
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain sequence

<400> 245
Glu Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          
Ser Tyr Tyr Trp Asp Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              
Trp Ile Gly Asn Ile Tyr Lys Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Glu Arg Gly Met His Tyr Met Asp Val Trp Gly Lys Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             



<210> 246
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain sequence

<400> 246
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gln Phe Asp Pro Pro Phe 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210> 247
<211> 451
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain sequence

<400> 247
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Trp Ser Gly 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Glu Gly Pro Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Ile Val Ala Ala Asp His Leu Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         
Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             
Pro Gly Lys 
    450     

<210> 248
<211> 218
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain sequence

<400> 248
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      
Leu Gln Gly Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             

<210> 249
<211> 451
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain sequence

<400> 249
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Trp 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Phe Gly Glu Ala Ala Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ala Arg Glu Gly Asp Asp Pro Tyr Gly Met Asp Val Trp Gly 
            100                 105                 110         
Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             
Pro Gly Lys 
    450     

<210> 250
<211> 218
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain sequence

<400> 250
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      
Lys Arg Leu Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             

<210> 251
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain sequence

<400> 251
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Trp 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Phe Gly Glu Ala Ala Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ala Arg Glu Gly Asp Asp Pro Tyr Gly Met Asp Val Trp Gly 
            100                 105                 110         
Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             
Pro Gly 
    450 

<210> 252
<211> 218
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain sequence

<400> 252
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      
Lys Arg Leu Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             

<210> 253
<211> 451
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain sequence

<400> 253
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Ile Trp Ser Glu 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Phe Gly Asp Ala Val Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ala Arg Glu Gly Asp Asp Pro Tyr Gly Met Asp Val Trp Gly 
            100                 105                 110         
Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             
Pro Gly Lys 
    450     

<210> 254
<211> 218
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain sequence

<400> 254
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Leu Ala Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      
Arg Arg Leu Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             

<210> 255
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain sequence

<400> 255
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Ile Trp Ser Glu 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Phe Gly Asp Ala Val Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ala Arg Glu Gly Asp Asp Pro Tyr Gly Met Asp Val Trp Gly 
            100                 105                 110         
Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             
Pro Gly 
    450 

<210> 256
<211> 218
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain sequence

<400> 256
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Leu Ala Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      
Arg Arg Leu Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             

<210> 257
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR1 Sequence

<400> 257
Tyr Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   

<210> 258
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR2 Sequence

<400> 258
Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 259
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR3 Sequence

<400> 259
Ala Arg Gly Thr Met Val Ser Arg Pro Ser Leu Asp Leu 
1               5                   10              

<210> 260
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR1 Sequence

<400> 260
Tyr Thr Phe Arg Arg Tyr Tyr Met His 
1               5                   

<210> 261
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR2 Sequence

<400> 261
Ile Ile Asn Pro His Val Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 262
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR3 Sequence

<400> 262
Ala Arg Gly Pro Asp Thr Ala Ile His Gln Gly Pro Ala Phe Asp Ile 
1               5                   10                  15      



<210> 263
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR1 Sequence

<400> 263
Tyr Thr Phe Thr Ser Tyr Tyr Met His 
1               5                   

<210> 264
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR2 Sequence

<400> 264
Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 265
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR3 Sequence

<400> 265
Ala Arg Gln Gly Ala Gly Gly Thr Met His Phe Asp Tyr 
1               5                   10              

<210> 266
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR1 Sequence

<400> 266
Tyr Thr Phe Gln Ala Tyr Tyr Met His 
1               5                   

<210> 267
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR2 Sequence

<400> 267
Ile Ile Asn Pro Ser Asn Gly His Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 268
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR3 Sequence

<400> 268
Ala Arg Gln Gly Ala Gly Gly Thr Met His Phe Asp Tyr 
1               5                   10              

<210> 269
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR1 Sequence

<400> 269
Tyr Thr Phe Pro Ser Tyr Tyr Met His 
1               5                   

<210> 270
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR2 Sequence

<400> 270
Ile Ile Asn Pro Ser Gly Gly Asn Thr His Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 271
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR3 Sequence

<400> 271
Ala Arg Gln Gly Ala Gly Gly Thr Met His Phe Asp Tyr 
1               5                   10              

<210> 272
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR1 Sequence

<400> 272
Tyr Thr Phe Asp Ser Leu Tyr Met His 
1               5                   

<210> 273
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR2 Sequence

<400> 273
Ile Ile Asn Pro Ser Asn Gly Arg Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 274
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR3 Sequence

<400> 274
Ala Arg Gln Gly Ala Gly Gly Thr Met His Phe Asp Tyr 
1               5                   10              

<210> 275
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR1 Sequence

<400> 275
Tyr Thr Phe Glu Glu Tyr Tyr Met His 
1               5                   

<210> 276
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR2 Sequence

<400> 276
Ile Ile Asn Pro Ser Asn Gly Arg Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 277
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR3 Sequence

<400> 277
Ala Arg Gln Gly Ala Gly Gly Thr Met His Phe Asp Tyr 
1               5                   10              

<210> 278
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR1 Sequence

<400> 278
Tyr Thr Phe Thr Arg Tyr Tyr Met His 
1               5                   

<210> 279
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR2 Sequence

<400> 279
Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 280
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR3 Sequence

<400> 280
Ala Arg Asp Pro Pro Met Gly Gln Gly Met Asp Val 
1               5                   10          

<210> 281
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR1 Sequence

<400> 281
Tyr Thr Phe Thr Arg Tyr Tyr Met His 
1               5                   

<210> 282
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR2 Sequence

<400> 282
Trp Ile Asn Pro Asn Ser Asp Gly Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 283
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR3 Sequence

<400> 283
Ala Arg Asp Pro Pro Met Gly Gln Gly Met Asp Val 
1               5                   10          

<210> 284
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR1 Sequence

<400> 284
Tyr Thr Phe Glu Ser Tyr Tyr Met His 
1               5                   

<210> 285
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR2 Sequence

<400> 285
Trp Ile Asn Pro Pro Ser Gly Arg Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 286
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR3 Sequence

<400> 286
Ala Arg Asp Pro Pro Met Gly Gln Gly Met Asp Val 
1               5                   10          

<210> 287
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR1 Sequence

<400> 287
Tyr Thr Phe Thr Arg Tyr Tyr Met His 
1               5                   

<210> 288
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR2 Sequence

<400> 288
Trp Ile Asn Pro Pro Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 289
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR3 Sequence

<400> 289
Ala Arg Asp Pro Pro Met Gly Gln Gly Met Asp Val 
1               5                   10          

<210> 290
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR1 Sequence

<400> 290
Tyr Thr Phe Thr Ser Arg Tyr Met His 
1               5                   

<210> 291
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR2 Sequence

<400> 291
Ile Ile Asn Pro Arg Leu Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 292
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR3 Sequence

<400> 292
Ala Arg Asp Gly Glu Val Gly Ala Arg Asp Leu Gly Trp Phe Asp Pro 
1               5                   10                  15      



<210> 293
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR1 Sequence

<400> 293
Tyr Thr Phe Arg Ser Arg Tyr Met His 
1               5                   

<210> 294
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR2 Sequence

<400> 294
Ile Ile Asn Pro Met Tyr Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 295
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR3 Sequence

<400> 295
Ala Arg Asp Gly Glu Val Gly Ala Arg Asp Leu Gly Trp Phe Asp Pro 
1               5                   10                  15      



<210> 296
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR1 Sequence

<400> 296
Tyr Thr Phe Gly Ser His Tyr Met His 
1               5                   

<210> 297
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR2 Sequence

<400> 297
Ile Ile Asn Pro Ser Ile Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 298
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR3 Sequence

<400> 298
Ala Arg Asp Gly Glu Val Gly Ala Arg Asp Leu Gly Trp Phe Asp Pro 
1               5                   10                  15      



<210> 299
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR1 Sequence

<400> 299
Tyr Thr Phe Ser His Tyr Tyr Met His 
1               5                   

<210> 300
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR2 Sequence

<400> 300
Ile Ile Asn Pro Arg Tyr Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 301
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR3 Sequence

<400> 301
Ala Arg Asp Gly Glu Val Gly Ala Arg Asp Leu Gly Trp Phe Asp Pro 
1               5                   10                  15      



<210> 302
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR1 Sequence

<400> 302
Tyr Thr Phe Pro Ser Arg Tyr Met His 
1               5                   

<210> 303
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR2 Sequence

<400> 303
Ile Ile Asn Pro Ser Leu Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 304
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR3 Sequence

<400> 304
Ala Arg Asp Gly Glu Val Gly Ala Arg Asp Leu Gly Trp Phe Asp Pro 
1               5                   10                  15      



<210> 305
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR1 Sequence

<400> 305
Tyr Thr Phe Ala Leu Tyr Tyr Met His 
1               5                   

<210> 306
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR2 Sequence

<400> 306
Ile Ile Asn Pro His Val Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 307
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR3 Sequence

<400> 307
Ala Arg Gly Arg Pro Leu Ser Gly Thr Gly Gly His His Tyr Phe Asp 
1               5                   10                  15      
Tyr 
    

<210> 308
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR1 Sequence

<400> 308
Tyr Thr Phe Met Arg Tyr Tyr Met His 
1               5                   

<210> 309
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR2 Sequence

<400> 309
Ile Ile Asn Pro Gly Leu Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 310
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR3 Sequence

<400> 310
Ala Arg Gly Arg Pro Leu Ser Gly Thr Gly Gly His His Tyr Phe Asp 
1               5                   10                  15      
Tyr 
    

<210> 311
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR1 Sequence

<400> 311
Tyr Thr Phe Gly Glu Tyr Tyr Met His 
1               5                   

<210> 312
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR2 Sequence

<400> 312
Ile Ile Asn Pro Arg Phe Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 313
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR3 Sequence

<400> 313
Ala Arg Gly Arg Pro Leu Ser Gly Thr Gly Gly His His Tyr Phe Asp 
1               5                   10                  15      
Tyr 
    

<210> 314
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR1 Sequence

<400> 314
Tyr Thr Phe Thr Ser Tyr Tyr Met His 
1               5                   

<210> 315
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR2 Sequence

<400> 315
Ile Ile Asn Pro Arg Val Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 316
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR3 Sequence

<400> 316
Ala Arg Gly Arg Pro Leu Ser Gly Thr Gly Gly His His Tyr Phe Asp 
1               5                   10                  15      
Tyr 
    

<210> 317
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR4 Sequence

<400> 317
Arg Ala Ser Gln Ser Val Ser Ser Ser Leu Ala 
1               5                   10      

<210> 318
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR5 Sequence

<400> 318
Gly Ala Ser Thr Arg Ala Thr 
1               5           

<210> 319
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR6 Sequence

<400> 319
Gln Gln Asp Asn Val Trp Pro Ile Thr 
1               5                   

<210> 320
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR4 Sequence

<400> 320
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      

<210> 321
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR5 Sequence

<400> 321
Ala Ala Ser Ser Leu Gln Ser 
1               5           

<210> 322
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR6 Sequence

<400> 322
Gln Gln Asp Ala Val Ile Pro Pro Phe Thr 
1               5                   10  

<210> 323
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR4 Sequence

<400> 323
Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      

<210> 324
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR5 Sequence

<400> 324
Asp Ala Ser Asn Arg Ala Thr 
1               5           

<210> 325
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR6 Sequence

<400> 325
Gln Gln Arg Ala Pro Phe Phe Thr 
1               5               

<210> 326
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR4 Sequence

<400> 326
Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      

<210> 327
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR5 Sequence

<400> 327
Asp Ala Ser Asn Arg Ala Thr 
1               5           

<210> 328
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR6 Sequence

<400> 328
Gln Gln Arg Ala Pro Phe Phe Thr 
1               5               

<210> 329
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR4 Sequence

<400> 329
Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      

<210> 330
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR5 Sequence

<400> 330
Asp Ala Ser Asn Arg Ala Thr 
1               5           

<210> 331
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR6 Sequence

<400> 331
Gln Gln Arg Ala Pro Phe Phe Thr 
1               5               

<210> 332
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR4 Sequence

<400> 332
Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      

<210> 333
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR5 Sequence

<400> 333
Asp Ala Ser Asn Arg Ala Thr 
1               5           

<210> 334
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR6 Sequence

<400> 334
Gln Gln Arg Ala Pro Phe Phe Thr 
1               5               

<210> 335
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR4 Sequence

<400> 335
Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      

<210> 336
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR5 Sequence

<400> 336
Asp Ala Ser Asn Arg Ala Thr 
1               5           

<210> 337
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR6 Sequence

<400> 337
Gln Gln Arg Ala Pro Phe Phe Thr 
1               5               

<210> 338
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR4 Sequence

<400> 338
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      

<210> 339
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR5 Sequence

<400> 339
Ala Ala Ser Ser Leu Gln Ser 
1               5           

<210> 340
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR6 Sequence

<400> 340
Gln Gln Gly Phe Ser Ser Pro Phe Thr 
1               5                   

<210> 341
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR4 Sequence

<400> 341
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      

<210> 342
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR5 Sequence

<400> 342
Ala Ala Ser Ser Leu Gln Ser 
1               5           

<210> 343
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR6 Sequence

<400> 343
Gln Gln Ser Phe Val Ala Pro Phe Thr 
1               5                   

<210> 344
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR4 Sequence

<400> 344
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      

<210> 345
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR5 Sequence

<400> 345
Ala Ala Ser Ser Leu Gln Ser 
1               5           

<210> 346
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR6 Sequence

<400> 346
Gln Gln Ser Phe Val Ala Pro Phe Thr 
1               5                   

<210> 347
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR4 Sequence

<400> 347
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      

<210> 348
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR5 Sequence

<400> 348
Ala Ala Ser Ser Leu Gln Ser 
1               5           

<210> 349
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR6 Sequence

<400> 349
Gln Gln Ser Phe Val Ala Pro Phe Thr 
1               5                   

<210> 350
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR4 Sequence

<400> 350
Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 
1               5                   10      

<210> 351
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR5 Sequence

<400> 351
Gly Ala Ser Thr Arg Ala Thr 
1               5           

<210> 352
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR6 Sequence

<400> 352
Gln Gln Tyr Thr Pro Leu Pro Trp Thr 
1               5                   

<210> 353
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR4 Sequence

<400> 353
Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 
1               5                   10      

<210> 354
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR5 Sequence

<400> 354
Gly Ala Ser Thr Arg Ala Thr 
1               5           

<210> 355
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR6 Sequence

<400> 355
Gln Gln Tyr Thr Pro Leu Pro Trp Thr 
1               5                   

<210> 356
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR4 Sequence

<400> 356
Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 
1               5                   10      

<210> 357
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR5 Sequence

<400> 357
Gly Ala Ser Thr Arg Ala Thr 
1               5           

<210> 358
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR6 Sequence

<400> 358
Gln Gln Tyr Thr Pro Leu Pro Trp Thr 
1               5                   

<210> 359
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR4 Sequence

<400> 359
Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 
1               5                   10      

<210> 360
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR5 Sequence

<400> 360
Gly Ala Ser Thr Arg Ala Thr 
1               5           

<210> 361
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR6 Sequence

<400> 361
Gln Gln Tyr Thr Pro Leu Pro Trp Thr 
1               5                   

<210> 362
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR4 Sequence

<400> 362
Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 
1               5                   10      

<210> 363
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR5 Sequence

<400> 363
Gly Ala Ser Thr Arg Ala Thr 
1               5           

<210> 364
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR6 Sequence

<400> 364
Gln Gln Tyr Thr Pro Leu Pro Trp Thr 
1               5                   

<210> 365
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR4 Sequence

<400> 365
Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      

<210> 366
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR5 Sequence

<400> 366
Asp Ala Ser Asn Leu Glu Thr 
1               5           

<210> 367
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR6 Sequence

<400> 367
Gln Gln Val Tyr Ala Leu Pro Pro Trp Thr 
1               5                   10  

<210> 368
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR4 Sequence

<400> 368
Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      

<210> 369
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR5 Sequence

<400> 369
Asp Ala Ser Asn Leu Glu Thr 
1               5           

<210> 370
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR6 Sequence

<400> 370
Gln Gln Val Tyr Ala Leu Pro Pro Trp Thr 
1               5                   10  

<210> 371
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR4 Sequence

<400> 371
Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      

<210> 372
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR5 Sequence

<400> 372
Asp Ala Ser Asn Leu Glu Thr 
1               5           

<210> 373
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR6 Sequence

<400> 373
Gln Gln Val Tyr Ala Leu Pro Pro Trp Thr 
1               5                   10  

<210> 374
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR4 Sequence

<400> 374
Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      

<210> 375
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR5 Sequence

<400> 375
Asp Ala Ser Asn Leu Glu Thr 
1               5           

<210> 376
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR6 Sequence

<400> 376
Gln Gln Val Tyr Ala Leu Pro Pro Trp Thr 
1               5                   10  

<210> 377
<211> 504
<212> PRT
<213> Staphylococcus aureus

<400> 377
Met Met Thr Leu Gln Ile His Thr Gly Gly Ile Asn Leu Lys Lys Lys 
1               5                   10                  15      
Asn Ile Tyr Ser Ile Arg Lys Leu Gly Val Gly Ile Ala Ser Val Thr 
            20                  25                  30          
Leu Gly Thr Leu Leu Ile Ser Gly Gly Val Thr Pro Ala Ala Asn Ala 
        35                  40                  45              
Ala Gln His Asp Glu Ala Gln Gln Asn Ala Phe Tyr Gln Val Leu Asn 
    50                  55                  60                  
Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser Leu 
65                  70                  75                  80  
Lys Asp Asp Pro Ser Gln Ser Ala Asn Val Leu Gly Glu Ala Gln Lys 
                85                  90                  95      
Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln Gln Asn Asn Phe 
            100                 105                 110         
Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn 
        115                 120                 125             
Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp 
    130                 135                 140                 
Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys Lys Leu Asn Glu 
145                 150                 155                 160 
Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys Glu Gln Gln Asn 
                165                 170                 175     
Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Glu Gln Arg 
            180                 185                 190         
Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn 
        195                 200                 205             
Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala 
    210                 215                 220                 
Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu 
225                 230                 235                 240 
His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser 
                245                 250                 255     
Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys 
            260                 265                 270         
Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys 
        275                 280                 285             
Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Thr 
    290                 295                 300                 
Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser 
305                 310                 315                 320 
Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln 
                325                 330                 335     
Ala Pro Lys Glu Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Asn Asn 
            340                 345                 350         
Lys Pro Gly Lys Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Asn Asn 
        355                 360                 365             
Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Asn Lys 
    370                 375                 380                 
Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Gly Asn 
385                 390                 395                 400 
Lys Pro Gly Lys Glu Asp Gly Asn Gly Val His Val Val Lys Pro Gly 
                405                 410                 415     
Asp Thr Val Asn Asp Ile Ala Lys Ala Asn Gly Thr Thr Ala Asp Lys 
            420                 425                 430         
Ile Ala Ala Asp Asn Lys Leu Ala Asp Lys Asn Met Ile Lys Pro Gly 
        435                 440                 445             
Gln Glu Leu Val Val Asp Lys Lys Gln Pro Ala Asn His Ala Asp Ala 
    450                 455                 460                 
Asn Lys Ala Gln Ala Leu Pro Glu Thr Gly Glu Glu Asn Pro Phe Ile 
465                 470                 475                 480 
Gly Thr Thr Val Phe Gly Gly Leu Ser Leu Ala Leu Gly Ala Ala Leu 
                485                 490                 495     
Leu Ala Gly Arg Arg Arg Glu Leu 
            500                 

<210> 378
<211> 492
<212> PRT
<213> Staphylococcus aureus

<400> 378
Met Lys Lys Lys Asn Ile Tyr Ser Ile Arg Lys Leu Gly Val Gly Ile 
1               5                   10                  15      
Ala Ser Val Thr Leu Gly Thr Leu Leu Ile Ser Gly Gly Val Thr Pro 
            20                  25                  30          
Ala Ala Asn Ala Ala Gln His Asp Glu Ala Gln Gln Asn Ala Phe Tyr 
        35                  40                  45              
Gln Val Leu Asn Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe 
    50                  55                  60                  
Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Val Leu Gly 
65                  70                  75                  80  
Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln 
                85                  90                  95      
Gln Asn Asn Phe Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile Leu 
            100                 105                 110         
Asn Met Pro Asn Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser 
        115                 120                 125             
Leu Lys Asp Asp Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys 
    130                 135                 140                 
Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys 
145                 150                 155                 160 
Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn 
                165                 170                 175     
Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser 
            180                 185                 190         
Gln Ser Ala Asn Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln 
        195                 200                 205             
Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe 
    210                 215                 220                 
Tyr Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly 
225                 230                 235                 240 
Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu 
                245                 250                 255     
Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn 
            260                 265                 270         
Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu His Leu 
        275                 280                 285             
Pro Asn Leu Thr Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys 
    290                 295                 300                 
Asp Asp Pro Ser Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu 
305                 310                 315                 320 
Asn Asp Ala Gln Ala Pro Lys Glu Glu Asp Asn Asn Lys Pro Gly Lys 
                325                 330                 335     
Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys 
            340                 345                 350         
Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys 
        355                 360                 365             
Glu Asp Asn Lys Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys 
    370                 375                 380                 
Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Gly Asn Gly Val His Val 
385                 390                 395                 400 
Val Lys Pro Gly Asp Thr Val Asn Asp Ile Ala Lys Ala Asn Gly Thr 
                405                 410                 415     
Thr Ala Asp Lys Ile Ala Ala Asp Asn Lys Leu Ala Asp Lys Asn Met 
            420                 425                 430         
Ile Lys Pro Gly Gln Glu Leu Val Val Asp Lys Lys Gln Pro Ala Asn 
        435                 440                 445             
His Ala Asp Ala Asn Lys Ala Gln Ala Leu Pro Glu Thr Gly Glu Glu 
    450                 455                 460                 
Asn Pro Phe Ile Gly Thr Thr Val Phe Gly Gly Leu Ser Leu Ala Leu 
465                 470                 475                 480 
Gly Ala Ala Leu Leu Ala Gly Arg Arg Arg Glu Leu 
                485                 490         

<210> 379
<211> 520
<212> PRT
<213> Staphylococcus aureus

<400> 379
Met Met Thr Leu Gln Ile His Thr Gly Gly Ile Asn Leu Lys Lys Lys 
1               5                   10                  15      
Asn Ile Tyr Ser Ile Arg Lys Leu Gly Val Gly Ile Ala Ser Val Thr 
            20                  25                  30          
Leu Gly Thr Leu Leu Ile Ser Gly Gly Val Thr Pro Ala Ala Asn Ala 
        35                  40                  45              
Ala Gln His Asp Glu Ala Gln Gln Asn Ala Phe Tyr Gln Val Leu Asn 
    50                  55                  60                  
Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser Leu 
65                  70                  75                  80  
Lys Asp Asp Pro Ser Gln Ser Ala Asn Val Leu Gly Glu Ala Gln Lys 
                85                  90                  95      
Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln Gln Asn Asn Phe 
            100                 105                 110         
Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn 
        115                 120                 125             
Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp 
    130                 135                 140                 
Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys Lys Leu Asn Glu 
145                 150                 155                 160 
Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys Glu Gln Gln Asn 
                165                 170                 175     
Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Glu Gln Arg 
            180                 185                 190         
Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn 
        195                 200                 205             
Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala 
    210                 215                 220                 
Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu 
225                 230                 235                 240 
His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser 
                245                 250                 255     
Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys 
            260                 265                 270         
Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys 
        275                 280                 285             
Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Thr 
    290                 295                 300                 
Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser 
305                 310                 315                 320 
Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln 
                325                 330                 335     
Ala Pro Lys Glu Glu Asp Asn Lys Lys Pro Gly Lys Glu Asp Gly Asn 
            340                 345                 350         
Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Asn Lys 
        355                 360                 365             
Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Asn Asn 
    370                 375                 380                 
Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Asn Asn 
385                 390                 395                 400 
Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Gly Asn 
                405                 410                 415     
Lys Pro Gly Lys Glu Asp Gly Asn Gly Val His Val Val Lys Pro Gly 
            420                 425                 430         
Asp Thr Val Asn Asp Ile Ala Lys Ala Asn Gly Thr Thr Ala Asp Lys 
        435                 440                 445             
Ile Ala Ala Asp Asn Lys Leu Ala Asp Lys Asn Met Ile Lys Pro Gly 
    450                 455                 460                 
Gln Glu Leu Val Val Asp Lys Lys Gln Pro Ala Asn His Ala Asp Ala 
465                 470                 475                 480 
Asn Lys Ala Gln Ala Leu Pro Glu Thr Gly Glu Glu Asn Pro Phe Ile 
                485                 490                 495     
Gly Thr Thr Val Phe Gly Gly Leu Ser Leu Ala Leu Gly Ala Ala Leu 
            500                 505                 510         
Leu Ala Gly Arg Arg Arg Glu Leu 
        515                 520 

<210> 380
<211> 520
<212> PRT
<213> Staphylococcus aureus

<400> 380
Met Met Thr Leu Gln Ile His Thr Gly Gly Ile Asn Leu Lys Lys Lys 
1               5                   10                  15      
Asn Ile Tyr Ser Ile Arg Lys Leu Gly Val Gly Ile Ala Ser Val Thr 
            20                  25                  30          
Leu Gly Thr Leu Leu Ile Ser Gly Gly Val Thr Pro Ala Ala Asn Ala 
        35                  40                  45              
Ala Gln His Asp Glu Ala Gln Gln Asn Ala Phe Tyr Gln Val Leu Asn 
    50                  55                  60                  
Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser Leu 
65                  70                  75                  80  
Lys Asp Asp Pro Ser Gln Ser Ala Asn Val Leu Gly Glu Ala Gln Lys 
                85                  90                  95      
Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln Gln Asn Asn Phe 
            100                 105                 110         
Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn 
        115                 120                 125             
Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp 
    130                 135                 140                 
Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys Lys Leu Asn Glu 
145                 150                 155                 160 
Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys Glu Gln Gln Asn 
                165                 170                 175     
Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Glu Gln Arg 
            180                 185                 190         
Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn 
        195                 200                 205             
Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala 
    210                 215                 220                 
Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu 
225                 230                 235                 240 
His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser 
                245                 250                 255     
Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys 
            260                 265                 270         
Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys 
        275                 280                 285             
Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Thr 
    290                 295                 300                 
Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser 
305                 310                 315                 320 
Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln 
                325                 330                 335     
Ala Pro Lys Glu Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Asn Asn 
            340                 345                 350         
Lys Pro Gly Lys Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Asn Asn 
        355                 360                 365             
Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Asn Lys 
    370                 375                 380                 
Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Asn Lys 
385                 390                 395                 400 
Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Gly Asn 
                405                 410                 415     
Lys Pro Gly Lys Glu Asp Gly Asn Gly Val His Val Val Lys Pro Gly 
            420                 425                 430         
Asp Thr Val Asn Asp Ile Ala Lys Ala Asn Gly Thr Thr Ala Asp Lys 
        435                 440                 445             
Ile Ala Ala Asp Asn Lys Leu Ala Asp Lys Asn Met Ile Lys Pro Gly 
    450                 455                 460                 
Gln Glu Leu Val Val Asp Lys Lys Gln Pro Ala Asn His Ala Asp Ala 
465                 470                 475                 480 
Asn Lys Ala Gln Ala Leu Pro Glu Thr Gly Glu Glu Asn Pro Phe Ile 
                485                 490                 495     
Gly Thr Thr Val Phe Gly Gly Leu Ser Leu Ala Leu Gly Ala Ala Leu 
            500                 505                 510         
Leu Ala Gly Arg Arg Arg Glu Leu 
        515                 520 

<210> 381
<211> 520
<212> PRT
<213> Staphylococcus aureus

<400> 381
Met Met Thr Leu Gln Ile His Thr Gly Gly Ile Asn Leu Lys Lys Lys 
1               5                   10                  15      
Asn Ile Tyr Ser Ile Arg Lys Leu Gly Val Gly Ile Ala Ser Val Thr 
            20                  25                  30          
Leu Gly Thr Leu Leu Ile Ser Gly Gly Val Thr Pro Ala Ala Asn Ala 
        35                  40                  45              
Ala Gln His Asp Glu Ala Gln Gln Asn Ala Phe Tyr Gln Val Leu Asn 
    50                  55                  60                  
Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser Leu 
65                  70                  75                  80  
Lys Asp Asp Pro Ser Gln Ser Ala Asn Val Leu Gly Glu Ala Gln Lys 
                85                  90                  95      
Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln Gln Asn Asn Phe 
            100                 105                 110         
Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn 
        115                 120                 125             
Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp 
    130                 135                 140                 
Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys Lys Leu Asn Glu 
145                 150                 155                 160 
Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys Glu Gln Gln Asn 
                165                 170                 175     
Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Glu Gln Arg 
            180                 185                 190         
Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn 
        195                 200                 205             
Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala 
    210                 215                 220                 
Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu 
225                 230                 235                 240 
His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser 
                245                 250                 255     
Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys 
            260                 265                 270         
Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys 
        275                 280                 285             
Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Thr 
    290                 295                 300                 
Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser 
305                 310                 315                 320 
Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln 
                325                 330                 335     
Ala Pro Lys Glu Glu Asp Asn Lys Lys Pro Gly Lys Glu Asp Gly Asn 
            340                 345                 350         
Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Asn Lys 
        355                 360                 365             
Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Asn Asn 
    370                 375                 380                 
Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Asn Asn 
385                 390                 395                 400 
Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Gly Asn 
                405                 410                 415     
Lys Pro Gly Lys Glu Asp Gly Asn Gly Val His Val Val Lys Pro Gly 
            420                 425                 430         
Asp Thr Val Asn Asp Ile Ala Lys Ala Asn Gly Thr Thr Ala Asp Lys 
        435                 440                 445             
Ile Ala Ala Asp Asn Lys Leu Ala Asp Lys Asn Met Ile Lys Pro Gly 
    450                 455                 460                 
Gln Glu Leu Val Val Asp Lys Lys Gln Pro Ala Asn His Ala Asp Ala 
465                 470                 475                 480 
Asn Lys Ala Gln Ala Leu Pro Glu Thr Gly Glu Glu Asn Pro Phe Ile 
                485                 490                 495     
Gly Thr Thr Val Phe Gly Gly Leu Ser Leu Ala Leu Gly Ala Ala Leu 
            500                 505                 510         
Leu Ala Gly Arg Arg Arg Glu Leu 
        515                 520 

<210> 382
<211> 492
<212> PRT
<213> Staphylococcus aureus

<400> 382
Met Lys Lys Lys Asn Ile Tyr Ser Ile Arg Lys Leu Gly Val Gly Ile 
1               5                   10                  15      
Ala Ser Val Thr Leu Gly Thr Leu Leu Ile Ser Gly Gly Val Thr Pro 
            20                  25                  30          
Ala Ala Asn Ala Ala Gln His Asp Glu Ala Gln Gln Asn Ala Phe Tyr 
        35                  40                  45              
Gln Val Leu Asn Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe 
    50                  55                  60                  
Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Val Leu Gly 
65                  70                  75                  80  
Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln 
                85                  90                  95      
Gln Asn Asn Phe Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile Leu 
            100                 105                 110         
Asn Met Pro Asn Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser 
        115                 120                 125             
Leu Lys Asp Asp Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys 
    130                 135                 140                 
Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys 
145                 150                 155                 160 
Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn 
                165                 170                 175     
Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser 
            180                 185                 190         
Gln Ser Ala Asn Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln 
        195                 200                 205             
Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe 
    210                 215                 220                 
Tyr Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly 
225                 230                 235                 240 
Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu 
                245                 250                 255     
Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn 
            260                 265                 270         
Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu His Leu 
        275                 280                 285             
Pro Asn Leu Thr Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys 
    290                 295                 300                 
Asp Asp Pro Ser Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu 
305                 310                 315                 320 
Asn Asp Ala Gln Ala Pro Lys Glu Glu Asp Asn Asn Lys Pro Gly Lys 
                325                 330                 335     
Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys 
            340                 345                 350         
Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys 
        355                 360                 365             
Glu Asp Asn Lys Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys 
    370                 375                 380                 
Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Gly Asn Gly Val His Val 
385                 390                 395                 400 
Val Lys Pro Gly Asp Thr Val Asn Asp Ile Ala Lys Ala Asn Gly Thr 
                405                 410                 415     
Thr Ala Asp Lys Ile Ala Ala Asp Asn Lys Leu Ala Asp Lys Asn Met 
            420                 425                 430         
Ile Lys Pro Gly Gln Glu Leu Val Val Asp Lys Lys Gln Pro Ala Asn 
        435                 440                 445             
His Ala Asp Ala Asn Lys Ala Gln Ala Leu Pro Glu Thr Gly Glu Glu 
    450                 455                 460                 
Asn Pro Phe Ile Gly Thr Thr Val Phe Gly Gly Leu Ser Leu Ala Leu 
465                 470                 475                 480 
Gly Ala Ala Leu Leu Ala Gly Arg Arg Arg Glu Leu 
                485                 490         

<210> 383
<211> 516
<212> PRT
<213> Staphylococcus aureus

<400> 383
Met Lys Lys Lys Asn Ile Tyr Ser Ile Arg Lys Leu Gly Val Gly Ile 
1               5                   10                  15      
Ala Ser Val Thr Leu Gly Thr Leu Leu Ile Ser Gly Gly Val Thr Pro 
            20                  25                  30          
Ala Ala Asn Ala Ala Gln His Asp Glu Ala Gln Gln Asn Ala Phe Tyr 
        35                  40                  45              
Gln Val Leu Asn Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe 
    50                  55                  60                  
Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Val Leu Gly 
65                  70                  75                  80  
Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln 
                85                  90                  95      
Gln Asn Lys Phe Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile Leu 
            100                 105                 110         
Asn Met Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser 
        115                 120                 125             
Leu Lys Asp Asp Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys 
    130                 135                 140                 
Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys 
145                 150                 155                 160 
Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn 
                165                 170                 175     
Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser 
            180                 185                 190         
Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys Lys Leu Asn Glu Ser Gln 
        195                 200                 205             
Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe 
    210                 215                 220                 
Tyr Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly 
225                 230                 235                 240 
Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu 
                245                 250                 255     
Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn 
            260                 265                 270         
Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu His Leu 
        275                 280                 285             
Pro Asn Leu Thr Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys 
    290                 295                 300                 
Asp Asp Pro Ser Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu 
305                 310                 315                 320 
Asn Asp Ala Gln Ala Pro Lys Glu Glu Asp Asn Asn Lys Pro Gly Lys 
                325                 330                 335     
Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys 
            340                 345                 350         
Glu Asp Asn Lys Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys 
        355                 360                 365             
Glu Asp Asn Lys Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys 
    370                 375                 380                 
Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys 
385                 390                 395                 400 
Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys 
                405                 410                 415     
Glu Asp Gly Asn Gly Val His Val Val Lys Pro Gly Asp Thr Val Asn 
            420                 425                 430         
Asp Ile Ala Lys Ala Asn Gly Thr Thr Ala Asp Lys Ile Ala Ala Asp 
        435                 440                 445             
Asn Lys Leu Ala Asp Lys Asn Met Ile Lys Pro Gly Gln Glu Leu Val 
    450                 455                 460                 
Val Asp Lys Lys Gln Pro Ala Asn His Ala Asp Ala Asn Lys Ala Gln 
465                 470                 475                 480 
Ala Leu Pro Glu Thr Gly Glu Glu Asn Pro Phe Ile Gly Thr Thr Val 
                485                 490                 495     
Phe Gly Gly Leu Ser Leu Ala Leu Gly Ala Ala Leu Leu Ala Gly Arg 
            500                 505                 510         
Arg Arg Glu Leu 
        515     

<210> 384
<211> 450
<212> PRT
<213> Staphylococcus aureus

<400> 384
Met Lys Lys Lys Asn Ile Tyr Ser Ile Arg Lys Leu Gly Val Gly Ile 
1               5                   10                  15      
Ala Ser Val Thr Leu Gly Thr Leu Leu Ile Ser Gly Gly Val Thr Pro 
            20                  25                  30          
Ala Ala Asn Ala Ala Gln His Asp Glu Ala Gln Gln Asn Ala Phe Tyr 
        35                  40                  45              
Gln Val Leu Asn Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe 
    50                  55                  60                  
Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Val Leu Gly 
65                  70                  75                  80  
Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln 
                85                  90                  95      
Gln Asn Asn Phe Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile Leu 
            100                 105                 110         
Asn Met Pro Asn Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser 
        115                 120                 125             
Leu Lys Asp Asp Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys 
    130                 135                 140                 
Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys 
145                 150                 155                 160 
Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn 
                165                 170                 175     
Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser 
            180                 185                 190         
Gln Ser Ala Asn Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln 
        195                 200                 205             
Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe 
    210                 215                 220                 
Tyr Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly 
225                 230                 235                 240 
Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Val Ser Lys Glu Ile Leu 
                245                 250                 255     
Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Glu Glu Asp 
            260                 265                 270         
Asn Lys Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp 
        275                 280                 285             
Gly Asn Lys Pro Gly Lys Glu Asp Asn Lys Lys Pro Gly Lys Glu Asp 
    290                 295                 300                 
Gly Asn Lys Pro Gly Lys Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp 
305                 310                 315                 320 
Gly Asn Lys Pro Gly Lys Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp 
                325                 330                 335     
Gly Asn Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp 
            340                 345                 350         
Gly Asn Gly Val His Val Val Lys Pro Gly Asp Thr Val Asn Asp Ile 
        355                 360                 365             
Ala Lys Ala Asn Gly Thr Thr Ala Asp Lys Ile Ala Ala Asp Asn Lys 
    370                 375                 380                 
Leu Ala Asp Lys Asn Met Ile Lys Pro Gly Gln Glu Leu Val Val Asp 
385                 390                 395                 400 
Lys Lys Gln Pro Ala Asn His Ala Asp Ala Asn Lys Ala Gln Ala Leu 
                405                 410                 415     
Pro Glu Thr Gly Glu Glu Asn Pro Phe Ile Gly Thr Thr Val Phe Gly 
            420                 425                 430         
Gly Leu Ser Leu Ala Leu Gly Ala Ala Leu Leu Ala Gly Arg Arg Arg 
        435                 440                 445             
Glu Leu 
    450 

<210> 385
<211> 450
<212> PRT
<213> Staphylococcus aureus

<400> 385
Met Lys Lys Lys Asn Ile Tyr Ser Ile Arg Lys Leu Gly Val Gly Ile 
1               5                   10                  15      
Ala Ser Val Thr Leu Gly Thr Leu Leu Ile Ser Gly Gly Val Thr Pro 
            20                  25                  30          
Ala Ala Asn Ala Ala Gln His Asp Glu Ala Gln Gln Asn Ala Phe Tyr 
        35                  40                  45              
Gln Val Leu Asn Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe 
    50                  55                  60                  
Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Val Leu Gly 
65                  70                  75                  80  
Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln 
                85                  90                  95      
Gln Asn Asn Phe Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile Leu 
            100                 105                 110         
Asn Met Pro Asn Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser 
        115                 120                 125             
Leu Lys Asp Asp Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys 
    130                 135                 140                 
Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys 
145                 150                 155                 160 
Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn 
                165                 170                 175     
Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser 
            180                 185                 190         
Gln Ser Ala Asn Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln 
        195                 200                 205             
Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe 
    210                 215                 220                 
Tyr Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly 
225                 230                 235                 240 
Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Val Ser Lys Glu Ile Leu 
                245                 250                 255     
Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Glu Glu Asp 
            260                 265                 270         
Asn Lys Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp 
        275                 280                 285             
Gly Asn Lys Pro Gly Lys Glu Asp Asn Lys Lys Pro Gly Lys Glu Asp 
    290                 295                 300                 
Gly Asn Lys Pro Gly Lys Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp 
305                 310                 315                 320 
Gly Asn Lys Pro Gly Lys Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp 
                325                 330                 335     
Gly Asn Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp 
            340                 345                 350         
Gly Asn Gly Val His Val Val Lys Pro Gly Asp Thr Val Asn Asp Ile 
        355                 360                 365             
Ala Lys Ala Asn Gly Thr Thr Ala Asp Lys Ile Ala Ala Asp Asn Lys 
    370                 375                 380                 
Leu Ala Asp Lys Asn Met Ile Lys Pro Gly Gln Glu Leu Val Val Asp 
385                 390                 395                 400 
Lys Lys Gln Pro Ala Asn His Ala Asp Ala Asn Lys Ala Gln Ala Leu 
                405                 410                 415     
Pro Glu Thr Gly Glu Glu Asn Pro Phe Ile Gly Thr Thr Val Phe Gly 
            420                 425                 430         
Gly Leu Ser Leu Ala Leu Gly Ala Ala Leu Leu Ala Gly Arg Arg Arg 
        435                 440                 445             
Glu Leu 
    450 

<210> 386
<211> 450
<212> PRT
<213> Staphylococcus aureus

<400> 386
Met Lys Lys Lys Asn Ile Tyr Ser Ile Arg Lys Leu Gly Val Gly Ile 
1               5                   10                  15      
Ala Ser Val Thr Leu Gly Thr Leu Leu Ile Ser Gly Gly Val Thr Pro 
            20                  25                  30          
Ala Ala Asn Ala Ala Gln His Asp Glu Ala Gln Gln Asn Ala Phe Tyr 
        35                  40                  45              
Gln Val Leu Asn Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe 
    50                  55                  60                  
Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Val Leu Gly 
65                  70                  75                  80  
Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln 
                85                  90                  95      
Gln Asn Asn Phe Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile Leu 
            100                 105                 110         
Asn Met Pro Asn Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser 
        115                 120                 125             
Leu Lys Asp Asp Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys 
    130                 135                 140                 
Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys 
145                 150                 155                 160 
Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn 
                165                 170                 175     
Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser 
            180                 185                 190         
Gln Ser Ala Asn Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln 
        195                 200                 205             
Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe 
    210                 215                 220                 
Tyr Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly 
225                 230                 235                 240 
Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Val Ser Lys Glu Ile Leu 
                245                 250                 255     
Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Glu Glu Asp 
            260                 265                 270         
Asn Lys Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp 
        275                 280                 285             
Gly Asn Lys Pro Gly Lys Glu Asp Asn Lys Lys Pro Gly Lys Glu Asp 
    290                 295                 300                 
Gly Asn Lys Pro Gly Lys Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp 
305                 310                 315                 320 
Gly Asn Lys Pro Gly Lys Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp 
                325                 330                 335     
Gly Asn Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp 
            340                 345                 350         
Gly Asn Gly Val His Val Val Lys Pro Gly Asp Thr Val Asn Asp Ile 
        355                 360                 365             
Ala Lys Ala Asn Gly Thr Thr Ala Asp Lys Ile Ala Ala Asp Asn Lys 
    370                 375                 380                 
Leu Ala Asp Lys Asn Met Ile Lys Pro Gly Gln Glu Leu Val Val Asp 
385                 390                 395                 400 
Lys Lys Gln Pro Ala Asn His Ala Asp Ala Asn Lys Ala Gln Ala Leu 
                405                 410                 415     
Pro Glu Thr Gly Glu Glu Asn Pro Phe Ile Gly Thr Thr Val Phe Gly 
            420                 425                 430         
Gly Leu Ser Leu Ala Leu Gly Ala Ala Leu Leu Ala Gly Arg Arg Arg 
        435                 440                 445             
Glu Leu 
    450 

<210> 387
<211> 516
<212> PRT
<213> Staphylococcus aureus

<400> 387
Met Lys Lys Lys Asn Ile Tyr Ser Ile Arg Lys Leu Gly Val Gly Ile 
1               5                   10                  15      
Ala Ser Val Thr Leu Gly Thr Leu Leu Ile Ser Gly Gly Val Thr Pro 
            20                  25                  30          
Ala Ala Asn Ala Ala Gln His Asp Glu Ala Gln Gln Asn Ala Phe Tyr 
        35                  40                  45              
Gln Val Leu Asn Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe 
    50                  55                  60                  
Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Val Leu Gly 
65                  70                  75                  80  
Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln 
                85                  90                  95      
Gln Asn Asn Phe Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile Leu 
            100                 105                 110         
Asn Met Pro Asn Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser 
        115                 120                 125             
Leu Lys Asp Asp Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys 
    130                 135                 140                 
Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys 
145                 150                 155                 160 
Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn 
                165                 170                 175     
Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser 
            180                 185                 190         
Gln Ser Ala Asn Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln 
        195                 200                 205             
Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe 
    210                 215                 220                 
Tyr Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly 
225                 230                 235                 240 
Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu 
                245                 250                 255     
Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn 
            260                 265                 270         
Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu His Leu 
        275                 280                 285             
Pro Asn Leu Thr Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys 
    290                 295                 300                 
Asp Asp Pro Ser Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu 
305                 310                 315                 320 
Asn Asp Ala Gln Ala Pro Lys Glu Glu Asp Asn Asn Lys Pro Gly Lys 
                325                 330                 335     
Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Asn Asn Lys Pro Gly Lys 
            340                 345                 350         
Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Asn Asn Lys Pro Gly Lys 
        355                 360                 365             
Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Asn Lys Lys Pro Gly Lys 
    370                 375                 380                 
Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Asn Lys Lys Pro Gly Lys 
385                 390                 395                 400 
Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys 
                405                 410                 415     
Glu Asp Gly Asn Gly Val His Val Val Lys Pro Gly Asp Thr Val Asn 
            420                 425                 430         
Asp Ile Ala Lys Ala Asn Gly Thr Thr Ala Asp Lys Ile Ala Ala Asp 
        435                 440                 445             
Asn Lys Leu Ala Asp Lys Asn Met Ile Lys Pro Gly Gln Glu Leu Val 
    450                 455                 460                 
Val Asp Lys Lys Gln Pro Ala Asn His Ala Asp Ala Asn Lys Ala Gln 
465                 470                 475                 480 
Ala Leu Pro Glu Thr Gly Glu Glu Asn Pro Phe Ile Gly Thr Thr Val 
                485                 490                 495     
Phe Gly Gly Leu Ser Leu Ala Leu Gly Ala Ala Leu Leu Ala Gly Arg 
            500                 505                 510         
Arg Arg Glu Leu 
        515     

<210> 388
<211> 508
<212> PRT
<213> Staphylococcus aureus

<400> 388
Met Lys Lys Lys Asn Ile Tyr Ser Ile Arg Lys Leu Gly Val Gly Ile 
1               5                   10                  15      
Ala Ser Val Thr Leu Gly Thr Leu Leu Ile Ser Gly Gly Val Thr Pro 
            20                  25                  30          
Ala Ala Asn Ala Ala Gln His Asp Glu Ala Gln Gln Asn Ala Phe Tyr 
        35                  40                  45              
Gln Val Leu Asn Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe 
    50                  55                  60                  
Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Val Leu Gly 
65                  70                  75                  80  
Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln 
                85                  90                  95      
Gln Asn Asn Phe Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile Leu 
            100                 105                 110         
Asn Met Pro Asn Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser 
        115                 120                 125             
Leu Lys Asp Asp Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys 
    130                 135                 140                 
Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys 
145                 150                 155                 160 
Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn 
                165                 170                 175     
Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser 
            180                 185                 190         
Gln Ser Ala Asn Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln 
        195                 200                 205             
Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe 
    210                 215                 220                 
Tyr Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly 
225                 230                 235                 240 
Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu 
                245                 250                 255     
Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn 
            260                 265                 270         
Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu His Leu 
        275                 280                 285             
Pro Asn Leu Thr Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys 
    290                 295                 300                 
Asp Asp Pro Ser Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu 
305                 310                 315                 320 
Asn Asp Ala Gln Ala Pro Lys Glu Glu Asp Asn Asn Lys Pro Gly Lys 
                325                 330                 335     
Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Asn Asn Lys Pro Gly Lys 
            340                 345                 350         
Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys 
        355                 360                 365             
Glu Asp Asn Lys Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys 
    370                 375                 380                 
Glu Asp Asn Lys Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys 
385                 390                 395                 400 
Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Gly Asn Gly Val His Val 
                405                 410                 415     
Val Lys Pro Gly Asp Thr Val Asn Asp Ile Ala Lys Ala Asn Gly Thr 
            420                 425                 430         
Thr Ala Asp Lys Ile Ala Ala Asp Asn Lys Leu Ala Asp Lys Asn Met 
        435                 440                 445             
Ile Lys Pro Gly Gln Glu Leu Val Val Asp Lys Lys Gln Pro Ala Asn 
    450                 455                 460                 
His Ala Asp Ala Asn Lys Ala Gln Ala Leu Pro Glu Thr Gly Glu Glu 
465                 470                 475                 480 
Asn Pro Phe Ile Gly Thr Thr Val Phe Gly Gly Leu Ser Leu Ala Leu 
                485                 490                 495     
Gly Ala Ala Leu Leu Ala Gly Arg Arg Arg Glu Leu 
            500                 505             

<210> 389
<211> 508
<212> PRT
<213> Staphylococcus aureus

<400> 389
Met Lys Lys Lys Asn Ile Tyr Ser Ile Arg Lys Leu Gly Val Gly Ile 
1               5                   10                  15      
Ala Ser Val Thr Leu Gly Thr Leu Leu Ile Ser Gly Gly Val Thr Pro 
            20                  25                  30          
Ala Ala Asn Ala Ala Gln His Asp Glu Ala Gln Gln Asn Ala Phe Tyr 
        35                  40                  45              
Gln Val Leu Asn Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe 
    50                  55                  60                  
Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Val Leu Gly 
65                  70                  75                  80  
Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln 
                85                  90                  95      
Gln Asn Asn Phe Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile Leu 
            100                 105                 110         
Asn Met Pro Asn Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser 
        115                 120                 125             
Leu Lys Asp Asp Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys 
    130                 135                 140                 
Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys 
145                 150                 155                 160 
Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn 
                165                 170                 175     
Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser 
            180                 185                 190         
Gln Ser Ala Asn Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln 
        195                 200                 205             
Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe 
    210                 215                 220                 
Tyr Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly 
225                 230                 235                 240 
Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu 
                245                 250                 255     
Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn 
            260                 265                 270         
Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu His Leu 
        275                 280                 285             
Pro Asn Leu Thr Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys 
    290                 295                 300                 
Asp Asp Pro Ser Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu 
305                 310                 315                 320 
Asn Asp Ala Gln Ala Pro Lys Glu Glu Asp Asn Asn Lys Pro Gly Lys 
                325                 330                 335     
Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Asn Asn Lys Pro Gly Lys 
            340                 345                 350         
Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys 
        355                 360                 365             
Glu Asp Asn Lys Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys 
    370                 375                 380                 
Glu Asp Asn Lys Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys 
385                 390                 395                 400 
Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Gly Asn Gly Val His Val 
                405                 410                 415     
Val Lys Pro Gly Asp Thr Val Asn Asp Ile Ala Lys Ala Asn Gly Thr 
            420                 425                 430         
Thr Ala Asp Lys Ile Ala Ala Asp Asn Lys Leu Ala Asp Lys Asn Met 
        435                 440                 445             
Ile Lys Pro Gly Gln Glu Leu Val Val Asp Lys Lys Gln Pro Ala Asn 
    450                 455                 460                 
His Ala Asp Ala Asn Lys Ala Gln Ala Leu Pro Glu Thr Gly Glu Glu 
465                 470                 475                 480 
Asn Pro Phe Ile Gly Thr Thr Val Phe Gly Gly Leu Ser Leu Ala Leu 
                485                 490                 495     
Gly Ala Ala Leu Leu Ala Gly Arg Arg Arg Glu Leu 
            500                 505             

<210> 390
<211> 436
<212> PRT
<213> Staphylococcus aureus

<400> 390
Met Lys Asn Lys Tyr Ile Ser Lys Leu Leu Val Gly Ala Ala Thr Ile 
1               5                   10                  15      
Thr Leu Ala Thr Met Ile Ser Asn Gly Glu Ala Lys Ala Ser Glu Asn 
            20                  25                  30          
Thr Gln Gln Thr Ser Thr Lys His Gln Thr Thr Gln Asn Asn Tyr Val 
        35                  40                  45              
Thr Asp Gln Gln Lys Ala Phe Tyr Gln Val Leu His Leu Lys Gly Ile 
    50                  55                  60                  
Thr Glu Glu Gln Arg Asn Gln Tyr Ile Lys Thr Leu Arg Glu His Pro 
65                  70                  75                  80  
Glu Arg Ala Gln Glu Val Phe Ser Glu Ser Leu Lys Asp Ser Lys Asn 
                85                  90                  95      
Pro Asp Arg Arg Val Ala Gln Gln Asn Ala Phe Tyr Asn Val Leu Lys 
            100                 105                 110         
Asn Asp Asn Leu Thr Glu Gln Glu Lys Asn Asn Tyr Ile Ala Gln Ile 
        115                 120                 125             
Lys Glu Asn Pro Asp Arg Ser Gln Gln Val Trp Val Glu Ser Val Gln 
    130                 135                 140                 
Ser Ser Lys Ala Lys Glu Arg Gln Asn Ile Glu Asn Ala Asp Lys Ala 
145                 150                 155                 160 
Ile Lys Asp Phe Gln Asp Asn Lys Ala Pro His Asp Lys Ser Ala Ala 
                165                 170                 175     
Tyr Glu Ala Asn Ser Lys Leu Pro Lys Asp Leu Arg Asp Lys Asn Asn 
            180                 185                 190         
Arg Phe Val Glu Lys Val Ser Ile Glu Lys Ala Ile Val Arg His Asp 
        195                 200                 205             
Glu Arg Val Lys Ser Ala Asn Asp Ala Ile Ser Lys Leu Asn Glu Lys 
    210                 215                 220                 
Asp Ser Ile Glu Asn Arg Arg Leu Ala Gln Arg Glu Val Asn Lys Ala 
225                 230                 235                 240 
Pro Met Asp Val Lys Glu His Leu Gln Lys Gln Leu Asp Ala Leu Val 
                245                 250                 255     
Ala Gln Lys Asp Ala Glu Lys Lys Val Ala Pro Lys Val Glu Ala Pro 
            260                 265                 270         
Gln Ile Gln Ser Pro Gln Ile Glu Lys Pro Lys Val Glu Ser Pro Lys 
        275                 280                 285             
Val Glu Val Pro Gln Ile Gln Ser Pro Lys Val Glu Val Pro Gln Ser 
    290                 295                 300                 
Lys Leu Leu Gly Tyr Tyr Gln Ser Leu Lys Asp Ser Phe Asn Tyr Gly 
305                 310                 315                 320 
Tyr Lys Tyr Leu Thr Asp Thr Tyr Lys Ser Tyr Lys Glu Lys Tyr Asp 
                325                 330                 335     
Thr Ala Lys Tyr Tyr Tyr Asn Thr Tyr Tyr Lys Tyr Lys Gly Ala Ile 
            340                 345                 350         
Asp Gln Thr Val Leu Thr Val Leu Gly Ser Gly Ser Lys Ser Tyr Ile 
        355                 360                 365             
Gln Pro Leu Lys Val Asp Asp Lys Asn Gly Tyr Leu Ala Lys Ser Tyr 
    370                 375                 380                 
Ala Gln Val Arg Asn Tyr Val Thr Glu Ser Ile Asn Thr Gly Lys Val 
385                 390                 395                 400 
Leu Tyr Thr Phe Tyr Gln Asn Pro Thr Leu Val Lys Thr Ala Ile Lys 
                405                 410                 415     
Ala Gln Glu Thr Ala Ser Ser Ile Lys Asn Thr Leu Ser Asn Leu Leu 
            420                 425                 430         
Ser Phe Trp Lys 
        435     

<210> 391
<211> 61
<212> PRT
<213> Staphylococcus aureus

<400> 391
Ala Asp Asn Asn Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile 
1               5                   10                  15      
Leu Asn Met Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln 
            20                  25                  30          
Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ser Glu Ala 
        35                  40                  45              
Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Gly Gly Cys 
    50                  55                  60      

<210> 392
<211> 61
<212> PRT
<213> Staphylococcus aureus

<400> 392
Ala Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile 
1               5                   10                  15      
Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln 
            20                  25                  30          
Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
        35                  40                  45              
Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Gly Gly Cys 
    50                  55                  60      

<210> 393
<211> 61
<212> PRT
<213> Staphylococcus aureus

<400> 393
Ala Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile 
1               5                   10                  15      
Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Gly Phe Ile Gln 
            20                  25                  30          
Ser Leu Lys Asp Asp Pro Ser Val Ser Lys Glu Ile Leu Ala Glu Ala 
        35                  40                  45              
Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Gly Gly Cys 
    50                  55                  60      

<210> 394
<211> 64
<212> PRT
<213> Staphylococcus aureus

<400> 394
Ala Asp Ala Gln Gln Asn Asn Phe Asn Lys Asp Gln Gln Ser Ala Phe 
1               5                   10                  15      
Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Ala Gln Arg Asn Gly 
            20                  25                  30          
Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Thr Asn Val Leu 
        35                  40                  45              
Gly Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Gly Gly Cys 
    50                  55                  60                  



<210> 395
<211> 59
<212> PRT
<213> Staphylococcus aureus

<400> 395
Ala Gln His Asp Glu Ala Gln Gln Asn Ala Phe Tyr Gln Val Leu Asn 
1               5                   10                  15      
Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser Leu 
            20                  25                  30          
Lys Asp Asp Pro Ser Gln Ser Ala Asn Val Leu Gly Glu Ala Gln Lys 
        35                  40                  45              
Leu Asn Asp Ser Gln Ala Pro Lys Gly Gly Cys 
    50                  55                  

<210> 396
<211> 70
<212> PRT
<213> Staphylococcus aureus

<400> 396
Gly Ser Glu Asn Thr Gln Gln Thr Ser Thr Lys His Gln Thr Thr Gln 
1               5                   10                  15      
Asn Asn Tyr Val Thr Asp Gln Gln Lys Ala Phe Tyr Gln Val Leu His 
            20                  25                  30          
Leu Lys Gly Ile Thr Glu Glu Gln Arg Asn Gln Tyr Ile Lys Thr Leu 
        35                  40                  45              
Arg Glu His Pro Glu Arg Ala Gln Glu Val Phe Ser Glu Ser Leu Lys 
    50                  55                  60                  
Asp Ser Lys Gly Gly Cys 
65                  70  

<210> 397
<211> 64
<212> PRT
<213> Staphylococcus aureus

<400> 397
Gly Asn Pro Asp Arg Arg Val Ala Gln Gln Asn Ala Phe Tyr Asn Val 
1               5                   10                  15      
Leu Lys Asn Asp Asn Leu Thr Glu Gln Glu Lys Asn Asn Tyr Ile Ala 
            20                  25                  30          
Gln Ile Lys Glu Asn Pro Asp Arg Ser Gln Gln Val Trp Val Glu Ser 
        35                  40                  45              
Val Gln Ser Ser Lys Ala Lys Glu Arg Gln Asn Ile Glu Gly Gly Cys 
    50                  55                  60                  



<210> 398
<211> 59
<212> PRT
<213> Staphylococcus aureus

<400> 398
Ala Gln His Asp Glu Ala Lys Lys Asn Ala Phe Tyr Gln Val Leu Asn 
1               5                   10                  15      
Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser Leu 
            20                  25                  30          
Lys Ala Ala Pro Ser Gln Ser Ala Asn Val Leu Gly Glu Ala Gln Lys 
        35                  40                  45              
Leu Asn Asp Ser Gln Ala Pro Lys Gly Gly Cys 
    50                  55                  

<210> 399
<211> 64
<212> PRT
<213> Artificial Sequence

<220> 
<223> SpA-DKKAA mutant

<400> 399
Ala Asp Ala Gln Gln Asn Asn Phe Asn Lys Asp Lys Lys Ser Ala Phe 
1               5                   10                  15      
Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Ala Gln Arg Asn Gly 
            20                  25                  30          
Phe Ile Gln Ser Leu Lys Ala Ala Pro Ser Gln Ser Thr Asn Val Leu 
        35                  40                  45              
Gly Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Gly Gly Cys 
    50                  55                  60                  



<210> 400
<211> 64
<212> PRT
<213> Artificial Sequence

<220> 
<223> SpA-DKK mutant

<400> 400
Ala Asp Ala Gln Gln Asn Asn Phe Asn Lys Asp Lys Lys Ser Ala Phe 
1               5                   10                  15      
Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Ala Gln Arg Asn Gly 
            20                  25                  30          
Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Thr Asn Val Leu 
        35                  40                  45              
Gly Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Gly Gly Cys 
    50                  55                  60                  



<210> 401
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> SpA consensus sequence

<220> 
<221> MUTAGEN
<222> 3
<223> wherein X is any of N, S or K

<220> 
<221> MUTAGEN
<222> 7
<223> wherein X is any of E, Q or N

<220> 
<221> MUTAGEN
<222> 8
<223> wherein X is any of I or V

<400> 401
Gln Gln Xaa Ala Phe Tyr Xaa Xaa Leu 
1               5                   

<210> 402
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> SpA consensus sequence

<220> 
<221> MUTAGEN
<222> 15
<223> wherein X is any of Q or V

<400> 402
Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Xaa Ser 
1               5                   10                  15      



<210> 403
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> IGBP mutant consensus sequence

<220> 
<221> MUTAGEN
<222> 3
<223> wherein X is any of N, S or K

<220> 
<221> MUTAGEN
<222> 7
<223> wherein X is any of E, Q or N

<220> 
<221> MUTAGEN
<222> 8
<223> wherein X is any of I or V

<400> 403
Lys Lys Xaa Ala Phe Tyr Xaa Xaa Leu 
1               5                   

<210> 404
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> IGBP mutant consensus sequence

<220> 
<221> MUTAGEN
<222> 15
<223> wherein X is any of Q or V

<400> 404
Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Ala Ala Pro Ser Xaa Ser 
1               5                   10                  15      



<210> 405
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR1

<400> 405
Tyr Thr Phe Thr Gly Arg Tyr Met His 
1               5                   

<210> 406
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR2

<400> 406
Ile Ile Asn Pro Arg Leu Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 407
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR3

<400> 407
Ala Arg Asp Gly Glu Val Gly Ala Arg Asp Leu Gly Trp Phe Asp Pro 
1               5                   10                  15      



<210> 408
<211> 472
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy Chain

<400> 408
Met Glu Leu Gly Leu Cys Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      
Val Gln Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              
Thr Gly Arg Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  
Glu Trp Met Gly Ile Ile Asn Pro Arg Leu Gly Ser Thr Ser Tyr Ala 
65                  70                  75                  80  
Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser 
                85                  90                  95      
Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Asp Gly Glu Val Gly Ala Arg Asp Leu Gly Trp 
        115                 120                 125             
Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 
Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         

<210> 409
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy Chain

<400> 409
Met Glu Leu Gly Leu Cys Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      
Val Gln Cys Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              
Thr Gly Arg Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  
Glu Trp Met Gly Ile Ile Asn Pro Arg Leu Gly Ser Thr Ser Tyr Ala 
65                  70                  75                  80  
Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser 
                85                  90                  95      
Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Asp Gly Glu Val Gly Ala Arg Asp Leu Gly Trp 
        115                 120                 125             
Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 
Ser Leu Ser Leu Ser Pro Gly 
465                 470     

<210> 410
<211> 472
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy Chain

<400> 410
Met Glu Leu Gly Leu Cys Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      
Val Gln Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              
Thr Ser Arg Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  
Glu Trp Met Gly Ile Ile Asn Pro Arg Leu Gly Ser Thr Ser Tyr Ala 
65                  70                  75                  80  
Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser 
                85                  90                  95      
Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Asp Gly Glu Val Gly Ala Arg Asp Leu Gly Trp 
        115                 120                 125             
Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 
Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         

<210> 411
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy Chain

<400> 411
Met Glu Leu Gly Leu Cys Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      
Val Gln Cys Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              
Thr Ser Arg Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  
Glu Trp Met Gly Ile Ile Asn Pro Arg Leu Gly Ser Thr Ser Tyr Ala 
65                  70                  75                  80  
Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser 
                85                  90                  95      
Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Asp Gly Glu Val Gly Ala Arg Asp Leu Gly Trp 
        115                 120                 125             
Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 
Ser Leu Ser Leu Ser Pro Gly 
465                 470     

<210> 412
<211> 472
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy Chain

<400> 412
Met Glu Leu Gly Leu Cys Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      
Val Gln Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              
Arg Ser Arg Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  
Glu Trp Met Gly Ile Ile Asn Pro Met Tyr Gly Ser Thr Ser Tyr Ala 
65                  70                  75                  80  
Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser 
                85                  90                  95      
Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Asp Gly Glu Val Gly Ala Arg Asp Leu Gly Trp 
        115                 120                 125             
Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 
Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         

<210> 413
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy Chain

<400> 413
Met Glu Leu Gly Leu Cys Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      
Val Gln Cys Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              
Arg Ser Arg Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  
Glu Trp Met Gly Ile Ile Asn Pro Met Tyr Gly Ser Thr Ser Tyr Ala 
65                  70                  75                  80  
Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser 
                85                  90                  95      
Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Asp Gly Glu Val Gly Ala Arg Asp Leu Gly Trp 
        115                 120                 125             
Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 
Ser Leu Ser Leu Ser Pro Gly 
465                 470     

<210> 414
<211> 468
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy Chain

<400> 414
Met Glu Leu Gly Leu Cys Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      
Val Gln Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          
Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile 
        35                  40                  45              
Ser Ser Gly Met Gly Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  
Leu Glu Trp Ile Gly Ser Ile Asp Gln Arg Gly Ser Thr Tyr Tyr Asn 
65                  70                  75                  80  
Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn 
                85                  90                  95      
Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Asp Ala Gly His Gly Val Asp Met Asp Val Trp 
        115                 120                 125             
Gly Lys Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 
Ser Pro Gly Lys 
465             

<210> 415
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy Chain

<400> 415
Met Glu Leu Gly Leu Cys Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      
Val Gln Cys Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              
Ser His Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  
Glu Trp Met Gly Ile Ile Asn Pro Arg Tyr Gly Ser Thr Ser Tyr Ala 
65                  70                  75                  80  
Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser 
                85                  90                  95      
Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Asp Gly Glu Val Gly Ala Arg Asp Leu Gly Trp 
        115                 120                 125             
Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 
Ser Leu Ser Leu Ser Pro Gly 
465                 470     

<210> 416
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy Chain

<400> 416
Met Glu Leu Gly Leu Cys Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      
Val Gln Cys Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              
Ser His Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  
Glu Trp Met Gly Ile Ile Asn Pro Arg Tyr Gly Ser Thr Ser Tyr Ala 
65                  70                  75                  80  
Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser 
                85                  90                  95      
Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Asp Gly Glu Val Gly Ala Arg Asp Leu Gly Trp 
        115                 120                 125             
Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             
Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
    290                 295                 300                 
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             
Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys 
    450                 455                 460                 
Ser Leu Ser Leu Ser Pro Gly 
465                 470     

<210> 417
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy Chain

<400> 417
Met Glu Leu Gly Leu Cys Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      
Val Gln Cys Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              
Ser His Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  
Glu Trp Met Gly Ile Ile Asn Pro Arg Tyr Gly Ser Thr Ser Tyr Ala 
65                  70                  75                  80  
Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser 
                85                  90                  95      
Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Asp Gly Glu Val Gly Ala Arg Asp Leu Gly Trp 
        115                 120                 125             
Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             
Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys 
    450                 455                 460                 
Ser Leu Ser Leu Ser Pro Gly 
465                 470     

<210> 418
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy Chain

<400> 418
Met Glu Leu Gly Leu Cys Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      
Val Gln Cys Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              
Ser His Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  
Glu Trp Met Gly Ile Ile Asn Pro Arg Tyr Gly Ser Thr Ser Tyr Ala 
65                  70                  75                  80  
Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser 
                85                  90                  95      
Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Asp Gly Glu Val Gly Ala Arg Asp Leu Gly Trp 
        115                 120                 125             
Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             
Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Tyr Thr Gln Lys 
    450                 455                 460                 
Ser Leu Ser Leu Ser Pro Gly 
465                 470     

<210> 419
<211> 233
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light Chain

<400> 419
Met Glu Leu Gly Leu Cys Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      
Val Gln Cys Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val 
            20                  25                  30          
Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 
        35                  40                  45              
Ser Ser Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  
Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg 
65                  70                  75                  80  
Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      
Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Thr Pro 
            100                 105                 110         
Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             
Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 
Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 
Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     
Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         
Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             
Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 
Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             

<210> 420
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH CDR1

<220> 
<221> MUTAGEN
<222> 4
<223> wherein X is any of T, R, Q, P, D, E, G, S, A, M

<220> 
<221> MUTAGEN
<222> 5
<223> wherein X is any of S, R, A, E, H, L, G

<220> 
<221> MUTAGEN
<222> 6
<223> wherein X is any of Y, L, R, H

<220> 
<221> MUTAGEN
<222> 8
<223> wherein X is any of I, M

<400> 420
Tyr Thr Phe Xaa Xaa Xaa Tyr Xaa His 
1               5                   

<210> 421
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<221> MUTAGEN
<222> 1
<223> wherein X is any of I, W

<220> 
<223> VH CDR2

<220> 
<221> MUTAGEN
<222> 5
<223> wherein X is any of S, H, N, P, R, M, G

<220> 
<221> MUTAGEN
<222> 6
<223> wherein X is any of G, V, N, S, L, Y, I, V, F

<220> 
<221> MUTAGEN
<222> 7
<223> wherein X is any of G, D

<220> 
<221> MUTAGEN
<222> 8
<223> wherein X is any of S, H, N, R, G

<220> 
<221> MUTAGEN
<222> 10
<223> wherein X is any of S, H, N

<400> 421
Xaa Ile Asn Pro Xaa Xaa Xaa Xaa Thr Xaa Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 422
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<221> MUTAGEN
<222> 1
<223> wherein X is any of R, Q

<220> 
<223> VL CDR1

<220> 
<221> MUTAGEN
<222> 5
<223> wherein X is any of S, D

<220> 
<221> MUTAGEN
<222> 6
<223> wherein X is any of V, I

<220> 
<221> MUTAGEN
<222> 8
<223> wherein X is any of S, N

<220> 
<221> MUTAGEN
<222> 9
<223> wherein X is any of S, Y, N

<220> 
<221> MUTAGEN
<222> 11
<223> wherein X is any of A, N

<400> 422
Xaa Ala Ser Gln Xaa Xaa Ser Xaa Xaa Leu Xaa 
1               5                   10      

<210> 423
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<221> MUTAGEN
<222> 1
<223> wherein X is any of G, A, D

<220> 
<223> VL CDR2

<220> 
<221> MUTAGEN
<222> 4
<223> wherein X is any T, S, N

<220> 
<221> MUTAGEN
<222> 5
<223> wherein X is any R, L

<220> 
<221> MUTAGEN
<222> 6
<223> wherein X is any A, Q, E

<220> 
<221> MUTAGEN
<222> 7
<223> wherein X is any T, S

<400> 423
Xaa Ala Ser Xaa Xaa Xaa Xaa 
1               5           

