                         SEQUENCE LISTING

<110>  F. Hoffmann-La Roche AG
 
<120>  Mutant transaminases as well as methods and uses relating thereto

<130>  32802WO

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  457
<212>  PRT
<213>  Ruegeria sp. TM1040

<400>  1

Met Leu Lys Asn Asp Gln Leu Asp Gln Trp Asp Arg Asp Asn Phe Phe 
1               5                   10                  15      


His Pro Ser Thr His Leu Ala Gln His Ala Arg Gly Glu Ser Ala Asn 
            20                  25                  30          


Arg Val Ile Lys Thr Ala Ser Gly Val Phe Ile Glu Asp Arg Asp Gly 
        35                  40                  45              


Thr Lys Leu Leu Asp Ala Phe Ala Gly Leu Tyr Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Gln Glu Ile Ala Glu Ala Ile Ala Asp Gln Ala Arg Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Ser Tyr Val Gly His Gly Thr Glu Ala Ser Ile 
                85                  90                  95      


Thr Leu Ala Lys Met Ile Leu Asp Arg Ala Pro Lys Asn Met Ser Lys 
            100                 105                 110         


Val Tyr Phe Gly Leu Gly Gly Ser Asp Ala Asn Glu Thr Asn Val Lys 
        115                 120                 125             


Leu Ile Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Tyr His Gly Ser Gly Leu Val Thr Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Glu Leu Phe His Lys Lys Phe Asp Leu Pro Val 
                165                 170                 175     


Glu Gln Val Ile His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Glu Asp 
            180                 185                 190         


Leu Asn Gln Thr Glu Glu Gln Phe Val Ala His Cys Val Ala Glu Leu 
        195                 200                 205             


Glu Ala Leu Ile Glu Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Ile Leu Gly Thr Gly Gly Ile Val Pro Pro Pro Ala Gly 
225                 230                 235                 240 


Tyr Trp Glu Ala Ile Gln Thr Val Leu Asn Lys His Asp Ile Leu Leu 
                245                 250                 255     


Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met Phe 
            260                 265                 270         


Gly Ser Asp His Tyr Gly Leu Glu Pro Asp Ile Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Ile Val Ser Asp 
    290                 295                 300                 


Lys Val Trp Lys Val Leu Glu Gln Gly Thr Asp Glu Asn Gly Pro Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Leu Asp Glu Leu Asn Leu Val Ser Asn Ala 
            340                 345                 350         


Gly Glu Val Gly Ala Tyr Leu Asn Ala Thr Met Ala Glu Ala Leu Ser 
        355                 360                 365             


Gln His Ala Asn Val Gly Asp Val Arg Gly Glu Gly Leu Leu Cys Ala 
    370                 375                 380                 


Val Glu Phe Val Lys Asp Arg Asp Ser Arg Thr Phe Phe Asp Ala Ala 
385                 390                 395                 400 


Asp Lys Ile Gly Pro Gln Ile Ser Ala Lys Leu Leu Glu Gln Asp Lys 
                405                 410                 415     


Ile Ile Ala Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Phe Cys Leu Thr Arg Ala Glu Ala Asp Gln Val Val Glu Gly Thr 
        435                 440                 445             


Leu Arg Ala Val Lys Ala Val Leu Gly 
    450                 455         


<210>  2
<211>  1395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Transaminase plus tag

<400>  2
atgctgaaaa acgaccaact ggaccaatgg gaccgtgata acttcttcca cccgtcaacg       60

cacctggcgc aacatgcccg tggcgaatca gctaaccgtg tgatcaaaac cgcgtcgggc      120

gtttttattg aagatcgcga cggtacgaaa ctgctggatg ctttcgcggg cctgtattgc      180

gttaatgtcg gctacggtcg tcaggaaatt gccgaagcaa tcgctgatca agcgcgcgaa      240

ctggcctatt accatagcta tgtgggccac ggtaccgaag cttctatcac gctggcgaaa      300

atgattctgg atcgtgcccc gaaaaacatg agtaaagttt actttggtct gggcggttcc      360

gacgcaaacg aaaccaatgt caaactgatc tggtattaca acaatattct gggccgcccg      420

gagaaaaaga aaattatcag tcgttggcgc ggttatcatg gcagtggtct ggttaccggc      480

tccctgacgg gtctggaact gtttcataaa aaattcgatc tgccggtgga acaggttatt      540

cacaccgaag ccccgtatta ctttcgtcgc gaagacctga accagacgga agaacaattc      600

gtcgcacact gtgtggctga actggaagcg ctgatcgaac gtgaaggcgc ggataccatt      660

gcggccttca tcggcgaacc gattctgggt acgggcggta ttgtgccgcc gccggccggt      720

tattgggaag caatccagac cgtcctgaat aaacatgata ttctgctggt tgcggacgaa      780

gtggttaccg gctttggtcg cctgggcacg atgttcggtt ctgatcacta tggcctggaa      840

ccggacatta tcaccatcgc gaaaggtctg acgtcagcgt acgccccgct gagcggttct      900

attgtgtcgg ataaagtctg gaaagtgctg gaacagggca ccgacgaaaa cggtccgatc      960

ggccatggtt ggacgtatag cgcacacccg attggtgcag ctgcaggtgt tgcaaatctg     1020

aaactgctgg atgaactgaa cctggttagc aatgccggcg aagtcggtgc ctacctgaac     1080

gcaaccatgg cagaagctct gtcccaacat gctaatgttg gcgatgtccg tggcgaaggt     1140

ctgctgtgcg cggtggaatt tgttaaagat cgtgacagcc gcacgttttt cgatgccgca     1200

gacaaaatcg gtccgcagat ttctgcgaaa ctgctggaac aagataaaat tatcgcgcgt     1260

gccatgccgc agggcgacat tctgggtttt gccccgccgt tctgtctgac ccgcgcagaa     1320

gctgatcaag tcgtggaagg tacgctgcgc gctgtcaaag ccgttctggg ttcacatcac     1380

catcaccacc actaa                                                      1395


<210>  3
<211>  459
<212>  PRT
<213>  Mesorhizobium loti maff303099

<400>  3

Met Leu Asn Gln Ser Asn Glu Leu Asn Ala Trp Asp Arg Asp His Phe 
1               5                   10                  15      


Phe His Pro Ser Thr His Met Gly Thr His Ala Arg Gly Glu Ser Pro 
            20                  25                  30          


Thr Arg Ile Met Ala Gly Gly Glu Gly Val Thr Val Trp Asp Asn Asn 
        35                  40                  45              


Gly Arg Lys Ser Ile Asp Ala Phe Ala Gly Leu Tyr Cys Val Asn Val 
    50                  55                  60                  


Gly Tyr Gly Arg Gln Lys Ile Ala Asp Ala Ile Ala Thr Gln Ala Lys 
65                  70                  75                  80  


Asn Leu Ala Tyr Tyr His Ala Tyr Val Gly His Gly Thr Glu Ala Ser 
                85                  90                  95      


Ile Thr Leu Ala Lys Met Ile Ile Asp Arg Ala Pro Lys Gly Met Ser 
            100                 105                 110         


Arg Val Tyr Phe Gly Leu Ser Gly Ser Asp Ala Asn Glu Thr Asn Ile 
        115                 120                 125             


Lys Leu Ile Trp Tyr Tyr Asn Asn Val Leu Gly Arg Pro Glu Lys Lys 
    130                 135                 140                 


Lys Ile Ile Ser Arg Trp Arg Gly Tyr His Gly Ser Gly Val Met Thr 
145                 150                 155                 160 


Gly Ser Leu Thr Gly Leu Asp Leu Phe His Asn Ala Phe Asp Leu Pro 
                165                 170                 175     


Arg Ala Pro Val Leu His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Thr 
            180                 185                 190         


Asp Arg Ser Met Ser Glu Glu Gln Phe Ser Gln His Cys Ala Asp Lys 
        195                 200                 205             


Leu Glu Glu Met Ile Leu Ala Glu Gly Pro Glu Thr Ile Ala Ala Phe 
    210                 215                 220                 


Ile Gly Glu Pro Ile Leu Gly Thr Gly Gly Ile Val Pro Pro Pro Ala 
225                 230                 235                 240 


Gly Tyr Trp Glu Lys Ile Gln Ala Val Leu Lys Lys Tyr Asp Val Leu 
                245                 250                 255     


Leu Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met 
            260                 265                 270         


Phe Gly Ser Asp His Tyr Gly Ile Lys Pro Asp Leu Ile Thr Ile Ala 
        275                 280                 285             


Lys Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Val Ile Val Ala 
    290                 295                 300                 


Asp Arg Val Trp Gln Val Leu Val Gln Gly Ser Asp Lys Leu Gly Ser 
305                 310                 315                 320 


Leu Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Cys Val Ala Ala 
                325                 330                 335     


Gly Val Ala Asn Leu Glu Leu Ile Asp Glu Met Asp Leu Val Thr Asn 
            340                 345                 350         


Ala Gly Glu Thr Gly Ala Tyr Phe Arg Ala Glu Leu Ala Lys Ala Val 
        355                 360                 365             


Gly Gly His Lys Asn Val Gly Glu Val Arg Gly Asp Gly Met Leu Ala 
    370                 375                 380                 


Ala Val Glu Phe Val Ala Asp Lys Asp Asp Arg Val Phe Phe Asp Ala 
385                 390                 395                 400 


Ser Gln Lys Ile Gly Pro Gln Val Ala Thr Ala Leu Ala Ala Ser Gly 
                405                 410                 415     


Val Ile Gly Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Leu Cys Leu Thr Arg Glu Gln Ala Asp Ile Val Val Ser Lys Thr 
        435                 440                 445             


Ala Asp Ala Val Lys Ser Val Phe Ala Asn Leu 
    450                 455                 


<210>  4
<211>  1401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Transaminase plus tag

<400>  4
atgctgaacc aatcgaacga actgaacgcc tgggatcgcg accacttttt ccacccgtca       60

acgcacatgg gcacgcacgc acgcggcgaa agtccgaccc gtatcatggc cggcggtgaa      120

ggcgttacgg tctgggataa caatggtcgc aaatccattg acgcgtttgc cggcctgtat      180

tgcgtgaacg ttggctacgg tcgccagaaa attgcagatg ctatcgcgac ccaagctaaa      240

aatctggcgt attaccatgc ctatgtgggc cacggtaccg aagcgagcat tacgctggcc      300

aaaatgatta tcgatcgtgc gccgaaaggc atgtctcgcg tttacttcgg cctgagcggt      360

tctgatgcca acgaaaccaa catcaaactg atctggtact acaacaacgt cctgggccgt      420

ccggagaaaa agaaaattat ctcccgttgg cgcggttatc atggcagcgg tgttatgacc      480

ggctctctga cgggtctgga cctgtttcat aacgcattcg acctgccgcg tgctccggtg      540

ctgcacaccg aagccccgta ttactttcgt cgcacggatc gcagtatgtc cgaagaacag      600

ttcagccaac actgtgcaga caaactggaa gaaatgattc tggctgaagg cccggaaacc      660

attgcggcct ttatcggcga accgattctg ggtacgggcg gtatcgttcc gccgccggcg      720

ggttattggg aaaaaattca ggccgtcctg aaaaaatacg atgtgctgct ggttgcggac      780

gaagtggtta ccggctttgg tcgcctgggc acgatgttcg gttcagatca ttatggcatc      840

aaaccggacc tgattaccat cgcaaaaggc ctgacgagtg cctacgcacc gctgtccggt      900

gtcattgtgg cggatcgtgt gtggcaggtt ctggtccaag gctcagacaa actgggttcg      960

ctgggccatg gttggaccta ttcggcacac ccgatctgcg tggcagctgg tgttgccaac     1020

ctggaactga ttgatgaaat ggacctggtg accaatgcgg gcgaaacggg tgcatatttt     1080

cgtgctgaac tggctaaagc ggttggcggt cacaaaaatg tcggcgaagt gcgcggcgat     1140

ggtatgctgg cggccgttga attcgtcgca gataaagatg accgtgtgtt tttcgacgct     1200

tcacagaaaa tcggtccgca agtcgcaacc gcactggcag cttcgggtgt gatcggtcgt     1260

gcaatgccgc agggcgatat tctgggtttt gccccgccgc tgtgtctgac ccgtgaacag     1320

gcagatattg tcgtgagcaa aacggccgac gctgtcaaat cagtcttcgc aaacctgtca     1380

caccaccatc accaccacta a                                               1401


<210>  5
<211>  456
<212>  PRT
<213>  Oceanicola granulosus

<400>  5

Met Leu Lys Asn Asp Pro Leu Glu Gln Trp Asp Arg Asp His Phe Leu 
1               5                   10                  15      


His Pro Ser Thr His Leu Ala Glu Phe Ala Arg Gly Asn Val Ala His 
            20                  25                  30          


Arg Ile Val Ser Gly Gly Glu Gly Ser His Ile Val Asp Arg Asn Gly 
        35                  40                  45              


Thr Arg Leu Leu Asp Gly Phe Ala Gly Leu Tyr Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Arg Glu Ile Ala Asp Ala Ile Ala Lys Gln Ala Arg Glu 
65                  70                  75                  80  


Leu Ser Tyr Tyr His Ser Tyr Val Gly His Gly Thr Glu Ala Ser Val 
                85                  90                  95      


Thr Leu Ala His Met Ile Leu Glu Arg Ala Pro Ala Asn Met Ser Lys 
            100                 105                 110         


Val Phe Phe Gly Leu Gly Gly Ser Asp Ala Asn Glu Thr Asn Ile Lys 
        115                 120                 125             


Leu Ile Trp Tyr Met Asn Asn Ile Leu Gly Arg Pro Gly Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Tyr His Gly Ser Gly Leu Met Ser Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Pro Leu Phe His Lys Ala Phe Asp Leu Pro Leu 
                165                 170                 175     


Ala Pro Ile Leu His Thr Glu Ala Pro Tyr Tyr Tyr Arg Arg Pro Asn 
            180                 185                 190         


Ala Asp Met Ser Glu Glu Ala Phe Ser Ala Trp Cys Ala Ser Glu Leu 
        195                 200                 205             


Glu Ala Met Ile Gln Arg Glu Gly Pro Asp Thr Ile Ala Ala Phe Trp 
    210                 215                 220                 


Ala Glu Pro Val Leu Gly Thr Gly Gly Ile Val Pro Pro Pro Glu Gly 
225                 230                 235                 240 


Tyr Trp Ala Ala Ile Gln Glu Val Leu Asp Arg His Asp Ile Leu Leu 
                245                 250                 255     


Val Ala Asp Glu Val Ile Thr Gly Phe Gly Arg Leu Gly Thr Met Phe 
            260                 265                 270         


Gly Ser Asp His Tyr Gly Met Lys Pro Asp Val Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Val Leu Ser Glu 
    290                 295                 300                 


Lys Val Trp Lys Val Leu Glu Gln Gly Thr Asp Glu Met Gly Ala Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Ile Asp Glu Leu Gly Leu Ile Asp Asn Ala 
            340                 345                 350         


Ala Glu Val Gly Ala His Leu Arg Ala Gly Met Arg Asp Ala Leu Gly 
        355                 360                 365             


Glu His Pro Asn Val Gly Asp Ile Arg Gly Glu Gly Met Leu Cys Ala 
    370                 375                 380                 


Val Glu Leu Val Ser Asp Arg Glu Ser Lys Glu Gly Phe Asp Pro Ser 
385                 390                 395                 400 


Arg Lys Val Thr Val Asn Ala Val Ala His Leu Met Glu Asn Gly Val 
                405                 410                 415     


Ile Gly Arg Ala Met Pro His Ser Glu Thr Ile Gly Phe Ala Pro Pro 
            420                 425                 430         


Phe Cys Leu Thr Arg Asp Glu Ala Asp Glu Ile Val Ala Lys Thr Ala 
        435                 440                 445             


Ala Ala Val Lys Ala Val Leu Gly 
    450                 455     


<210>  6
<211>  460
<212>  PRT
<213>  Jannaschia Sp CCS1

<400>  6

Met Leu Thr Asn Asp Gln Leu Ser Gln Trp Asp Gln Asp His Phe Phe 
1               5                   10                  15      


His Pro Ser Thr Ala Leu Gly Ala His Ala Arg Gly Glu Ala Pro Gly 
            20                  25                  30          


Met Val Val Gln Thr Ala Glu Gly Cys His Ile Thr Asp Arg Asn Gly 
        35                  40                  45              


Asn Arg Met Leu Asp Ala Phe Ala Gly Leu Tyr Cys Val Asn Ile Gly 
    50                  55                  60                  


Tyr Gly Arg Gln Glu Val Ala Glu Ala Ile Ala Ala Gln Ala Arg Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Ser Tyr Met Gly Asn Gly Thr Glu Ala Ser Ile 
                85                  90                  95      


Thr Leu Ala Lys Met Val Thr Glu Arg Ala Pro Glu Gly Met Asn Arg 
            100                 105                 110         


Val Tyr Phe Gly Gln Gly Gly Ser Asp Ala Asn Glu Thr Asn Ile Lys 
        115                 120                 125             


Leu Val Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Val Ser Arg Trp Arg Gly Tyr His Gly Ser Gly Leu Met Ser Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Ser Leu Phe His Arg Lys Phe Asp Leu Pro Leu 
                165                 170                 175     


Asp Lys Val Leu His Thr Thr Ala Pro Tyr Tyr Phe Gln Arg Glu Asn 
            180                 185                 190         


Val Ala Gln Ser Glu Gln Glu Phe Thr Ala Gln Cys Val Ala Asp Leu 
        195                 200                 205             


Glu Glu Leu Ile Ala Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Ala Glu Pro Val Ile Gly Thr Gly Gly Ile Val Pro Pro Pro Glu Gly 
225                 230                 235                 240 


Tyr Trp Asn Ala Ile Gln Pro Val Leu Lys Arg His Asp Ile Leu Leu 
                245                 250                 255     


Ile Ala Asp Glu Val Ile Thr Gly Phe Gly Arg Leu Gly Ala Met Phe 
            260                 265                 270         


Gly Ser Pro Leu Tyr Gly Ile Glu Pro Asp Ile Met Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Ile Val His Asp 
    290                 295                 300                 


Arg Val Trp Asp Val Leu Ala Arg Gly Thr Asp Glu Asn Gly Pro Leu 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Thr Leu Leu Asp Thr Leu Gly Leu Val Asp Asn Ala 
            340                 345                 350         


Ala Asp Val Gly Pro Tyr Leu Thr Ala Gln Met Arg Ala Ala Met Gln 
        355                 360                 365             


Asp His Ala His Val Gly Asp Ile Arg Gly Val Gly Met Leu Thr Ala 
    370                 375                 380                 


Val Glu Leu Val Ala Asp Arg Asp Lys Gly Ser Gly Val Gly Ala Gly 
385                 390                 395                 400 


Phe Asp Pro Ala Ala Lys Ile Val Pro Gln Ile Ser Ala Ala Met Ala 
                405                 410                 415     


Lys Arg Gly Val Ile Ala Arg Ala Met Pro Gln Ala Asp Ile Val Gly 
            420                 425                 430         


Phe Ser Pro Pro Leu Cys Leu Thr Arg Ala Glu Ala Asp Thr Ile Val 
        435                 440                 445             


Ser Val Thr Ala Glu Ala Val Ala Glu Val Leu Gly 
    450                 455                 460 


<210>  7
<211>  464
<212>  PRT
<213>  Xanthobacteraceae

<400>  7

Met Leu Asp His Pro Ala Pro Ala Ser Asn Ala Phe Asp Ser Trp Asp 
1               5                   10                  15      


Arg Asp His Phe Phe His Pro Ser Thr His Met Gly Gln His Ala Arg 
            20                  25                  30          


Gly Glu Thr Pro Asn Arg Ile Ile Thr Gly Ala Glu Gly Val Tyr Ile 
        35                  40                  45              


Val Asp Arg Glu Gly Arg Arg Ser Leu Asp Ala Phe Gly Gly Leu Tyr 
    50                  55                  60                  


Cys Val Asn Val Gly Tyr Gly Arg Ser Lys Ile Thr Asp Ala Ile Ala 
65                  70                  75                  80  


Glu Gln Ala Ser Lys Leu Ala Tyr Tyr His Ala Tyr Ala Gly His Gly 
                85                  90                  95      


Ser Glu Pro Ser Ile Arg Leu Ala Arg Met Val Ile Glu Arg Ala Pro 
            100                 105                 110         


Ala Gly Met Ser Arg Val Phe Phe Gly Leu Ser Gly Ser Asp Ala Asn 
        115                 120                 125             


Glu Thr Asn Ile Lys Leu Val Trp Tyr Ile Asn Asn Val Leu Gly Arg 
    130                 135                 140                 


Pro Gln Lys Lys Lys Ile Ile Ser Arg Trp Arg Gly Tyr His Gly Ser 
145                 150                 155                 160 


Gly Val Met Thr Gly Ser Leu Thr Gly Leu Ala Gly Phe His Lys Leu 
                165                 170                 175     


Phe Asp Leu Pro Arg Ala Pro Ile Leu His Thr Glu Ala Pro Tyr Tyr 
            180                 185                 190         


Phe Arg Arg Glu Asp Arg Ser Met Ser Glu Glu Gln Phe Ser Gln His 
        195                 200                 205             


Cys Ala Asp Arg Leu Glu Glu Met Ile Leu Thr Glu Gly Ala Asp Thr 
    210                 215                 220                 


Ile Ala Ala Phe Ile Gly Glu Pro Val Leu Gly Thr Gly Gly Ile Val 
225                 230                 235                 240 


Pro Pro Pro Ala Gly Tyr Trp Pro Lys Ile Gln Ala Val Leu Lys Lys 
                245                 250                 255     


Tyr Asp Ile Met Leu Ile Ala Asp Glu Val Val Thr Gly Phe Gly Arg 
            260                 265                 270         


Leu Gly Ser Met Phe Gly Ser Asp His Tyr Gly Ile Glu Pro Asp Leu 
        275                 280                 285             


Ile Thr Ile Ala Lys Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly 
    290                 295                 300                 


Val Ile Val Ser Glu Lys Val Trp Arg Val Leu Glu Gln Gly Ser Asp 
305                 310                 315                 320 


Glu Phe Gly Pro Ile Gly His Gly Trp Thr Tyr Ser Ser His Pro Leu 
                325                 330                 335     


Cys Thr Ala Ala Gly Val Ala Asn Leu Glu Leu Val Asp Glu Leu Asp 
            340                 345                 350         


Leu Val Thr Asn Ala Arg Glu Thr Gly Ala Tyr Phe Asn Ala Ala Leu 
        355                 360                 365             


Lys Asp Ala Leu Ser Gly His Arg His Val Gly Glu Val Arg Gly Glu 
    370                 375                 380                 


Gly Leu Leu Ala Ala Val Glu Leu Val Arg Asp Arg Asp Asp Arg Thr 
385                 390                 395                 400 


Phe Phe Glu Ala Ser Glu Lys Val Gly Pro Arg Val Ala Ala Ala Met 
                405                 410                 415     


Leu Glu Arg Gly Val Ile Ala Arg Ala Met Pro Gln Gly Asp Ile Leu 
            420                 425                 430         


Gly Phe Ala Pro Pro Leu Cys Leu Thr Arg Glu Glu Ala Asp Ile Val 
        435                 440                 445             


Val Asp Ala Thr Arg Gly Ala Val Glu Ala Val Cys Ala Thr Leu Gly 
    450                 455                 460                 


<210>  8
<211>  457
<212>  PRT
<213>  Rhodobacteraceae bacterium RB2150_13166

<400>  8

Met Leu Arg Asn Asp Gln Leu Ala Glu Trp Asp Arg Glu Asn Phe Phe 
1               5                   10                  15      


His Ala Ser Thr His Leu Ala Ala His Ala Arg Gly Asp Thr Pro Thr 
            20                  25                  30          


Arg Ile Ile Thr Gly Gly Glu Gly Val Tyr Ile Gln Asp Arg Asp Gly 
        35                  40                  45              


Ala Lys Ile Leu Asp Gly Phe Ala Gly Leu Tyr Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Arg Glu Ile Thr Asp Ala Ile Ala Ala Gln Val Ser Glu 
65                  70                  75                  80  


Leu Ser Tyr Tyr His Ala Tyr Ala Gly His Gly Thr Glu Ala Ser Val 
                85                  90                  95      


Thr Leu Ala Lys Met Val Leu Asp Arg Ala Pro Asp Asn Met Ser Lys 
            100                 105                 110         


Val Tyr Phe Gly Leu Gly Gly Ser Asp Ala Asn Glu Thr Asn Ile Lys 
        115                 120                 125             


Leu Ile Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Tyr His Gly Ser Gly Leu Met Thr Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Gly Leu Phe His Ala Lys Phe Asp Leu Pro Met 
                165                 170                 175     


Asp Gly Val Leu His Thr Glu Ala Pro His Tyr Leu His Arg Ala Asp 
            180                 185                 190         


Arg Asn Gln Thr Glu Glu Gln Phe Ser Ala Tyr Cys Ala Ala Lys Leu 
        195                 200                 205             


Glu Glu Met Ile Leu Ala Glu Gly Pro Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Ile Leu Gly Thr Gly Gly Ile Val Pro Pro Pro Lys Gly 
225                 230                 235                 240 


Tyr Trp Ala Ala Ile Gln Ala Val Leu Arg Lys Tyr Asp Ile Leu Leu 
                245                 250                 255     


Val Val Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met Phe 
            260                 265                 270         


Gly Ser Glu His Tyr Gly Leu Lys Ala Asp Leu Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Ile Val Ser Lys 
    290                 295                 300                 


Lys Met Trp Ala Val Leu Glu Lys Gly Thr Asp Glu Asn Gly Ala Phe 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Ile Asp Asp Leu Gly Leu Ile Ala Asn Ala 
            340                 345                 350         


Ser Glu Thr Gly Ala Tyr Leu Lys Ser Ala Leu Gln Ala Ala Leu Gly 
        355                 360                 365             


Asp His Pro Asn Val Ala Glu Ile Arg Gly Glu Gly Met Leu Ala Ala 
    370                 375                 380                 


Val Glu Phe Cys Ala Asp Arg Asp Asp Leu Lys Gln Phe Asp Thr Ser 
385                 390                 395                 400 


Ala Thr Ile Gly Pro Arg Leu Ala Ala Glu Leu Leu Thr Arg Gly Val 
                405                 410                 415     


Ile Gly Arg Ala Met Pro Gln Ser Asp Thr Ile Gly Phe Ala Pro Pro 
            420                 425                 430         


Leu Cys Ile Thr Arg Ala Glu Val Asp Gln Ile Val Ala Ala Met Lys 
        435                 440                 445             


Gly Ala Val Asp Ala Val Leu Pro Ala 
    450                 455         


<210>  9
<211>  456
<212>  PRT
<213>  Martelella mediterranea DSM 17316

<400>  9

Met Leu Thr Asn Asp Gln Leu Asp Arg Phe Asp Arg Glu Asn Phe Phe 
1               5                   10                  15      


His Pro Ser Thr His Leu Ala Gln His Ala Arg Gly Glu Ser Pro Ser 
            20                  25                  30          


Arg Ile Val Lys Thr Ala Lys Gly Val Phe Ile Glu Asp Arg Asp Gly 
        35                  40                  45              


Asn Lys Leu Leu Asp Gly Phe Gly Gly Leu Tyr Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Gln Glu Ser Ile Ile Glu Ala Ile Ala Glu Gln Ala Lys Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Ala Tyr Ala Gly His Gly Thr Glu Ala Ser Ile 
                85                  90                  95      


Asn Leu Ala Lys Met Val Ile Asp Arg Ala Pro Asp His Met Ser Lys 
            100                 105                 110         


Val Tyr Phe Gly Leu Ser Gly Ser Asp Ala Asn Glu Thr Asn Ile Lys 
        115                 120                 125             


Leu Ile Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Tyr His Gly Ser Gly Leu Met Thr Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Ala Gly Phe Gln Arg Lys Phe Asp Leu Pro Leu 
                165                 170                 175     


Glu Arg Val Phe His Thr Thr Ala Pro Tyr Tyr Tyr Arg Arg Lys Asp 
            180                 185                 190         


Leu Ala Met Ser Glu Ala Asp Phe Val Ala His Cys Val Ala Glu Leu 
        195                 200                 205             


Glu Met Arg Ile Glu Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Val Leu Gly Thr Gly Gly Ile Val Pro Pro Pro Glu Gly 
225                 230                 235                 240 


Tyr Trp Lys Ala Ile Ser Ala Val Leu Glu Lys His Asp Ile Leu Leu 
                245                 250                 255     


Ile Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Ser Met Phe 
            260                 265                 270         


Gly Ser Asp His Tyr Gly Leu Lys Pro Asp Leu Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Thr Ile Val Ser Asp 
    290                 295                 300                 


Lys Val Trp Lys Val Leu Glu Gln Gly Thr Asp Glu Asn Gly Pro Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Ile Asp Glu Leu Gly Leu Val Lys Asn Ala 
            340                 345                 350         


Ala Glu Thr Gly Ala Tyr Leu Arg Ala Ala Met Lys Asp Ala Leu Ser 
        355                 360                 365             


Asp His Pro His Val Gly Asp Ile Arg Gly Glu Gly Met Leu Met Ala 
    370                 375                 380                 


Val Glu Phe Val Lys Asp Arg Glu Ser Arg Thr Phe Tyr Asp Pro Ser 
385                 390                 395                 400 


Glu Lys Val Gly Pro Asn Leu Ala Ala Ala Leu Ile Ser Glu Gly Val 
                405                 410                 415     


Ile Ala Arg Ala Met Pro Glu Gly Asp Ile Leu Gly Tyr Ala Pro Pro 
            420                 425                 430         


Leu Cys Leu Thr Arg Glu Glu Ala Asp Gln Ile Val Ala Ala Thr Lys 
        435                 440                 445             


Lys Ala Val Ile Ala Val Leu Gly 
    450                 455     


<210>  10
<211>  457
<212>  PRT
<213>  Rugeria pomeroyi DSS-3

<400>  10

Met Leu Lys Asn Asp Gln Leu Asp Gln Trp Asp Arg Glu Asn Phe Phe 
1               5                   10                  15      


His Pro Ser Thr His Leu Ala Gln His Ala Arg Gly Asp Ser Ala Asn 
            20                  25                  30          


Arg Val Ile Lys Thr Ala Ser Gly Val Phe Ile Glu Asp Arg Asp Gly 
        35                  40                  45              


Asn Lys Leu Leu Asp Ala Phe Ala Gly Leu Tyr Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Gln Glu Ile Ala Asp Ala Ile Ala Asp Gln Ala Arg Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Ser Tyr Val Gly His Gly Thr Glu Ala Ser Ile 
                85                  90                  95      


Thr Leu Ala Lys Met Ile Leu Asp Arg Ala Pro Ala Asn Met Ser Lys 
            100                 105                 110         


Val Tyr Phe Gly Leu Gly Gly Ser Asp Ala Asn Glu Thr Asn Val Lys 
        115                 120                 125             


Leu Ile Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Tyr His Gly Ser Gly Leu Val Thr Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Glu Leu Phe His Lys Lys Phe Asp Leu Pro Val 
                165                 170                 175     


Asn Gln Val Ile His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Ala Asp 
            180                 185                 190         


Pro Asp Gln Ser Glu Ala Gln Phe Val Ala His Cys Ala Ala Glu Leu 
        195                 200                 205             


Glu Ala Leu Ile Glu Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Val Leu Gly Thr Gly Gly Ile Val Pro Pro Pro Ala Gly 
225                 230                 235                 240 


Tyr Trp Glu Ala Ile Gln Ala Val Leu Arg Lys His Asp Ile Leu Leu 
                245                 250                 255     


Ile Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met Phe 
            260                 265                 270         


Gly Ser Asp His Tyr Gly Ile Glu Ala Asp Ile Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Ile Ile Ser Asp 
    290                 295                 300                 


Lys Val Trp Lys Val Leu Glu Gln Gly Thr Asp Glu Asn Gly Pro Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Ile Asp Arg Leu Asn Leu Val Gln Asn Ala 
            340                 345                 350         


Gly Glu Thr Gly Ala Tyr Leu Asn Ala Thr Met Thr Glu Ala Leu Ala 
        355                 360                 365             


Gly His Pro Asn Val Gly Glu Val Arg Gly Ala Gly Met Leu Cys Ala 
    370                 375                 380                 


Val Glu Phe Val Lys Asp Lys Asp Ser Arg Leu Phe Phe Asp Ala Ala 
385                 390                 395                 400 


Asp Lys Ile Gly Pro Gln Ile Ser Ala Lys Leu Leu Glu Gln Asp Lys 
                405                 410                 415     


Val Ile Ala Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Phe Cys Leu Ser Arg Ala Glu Ala Asp Gln Val Val Asp Ala Thr 
        435                 440                 445             


Leu Arg Ala Val Arg Thr Val Leu Gly 
    450                 455         


<210>  11
<211>  456
<212>  PRT
<213>  Sagittula stellata E-37

<400>  11

Met Leu Thr Asn Asp Gln Leu Ser Gln Trp Asp Arg Glu Asn Phe Phe 
1               5                   10                  15      


His Pro Ser Thr His Leu Ala Gln His Ala Arg Gly Glu Thr Ala Thr 
            20                  25                  30          


Arg Val Ile Thr Thr Gly Gln Gly Cys His Ile Glu Asp Arg Asp Gly 
        35                  40                  45              


Thr Lys Leu Leu Asp Ala Phe Ala Gly Leu Tyr Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Thr Glu Ile Ala Asp Ala Ile Ala Ala Gln Ala Lys Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Ala Tyr Val Gly His Gly Thr Glu Ala Ser Ile 
                85                  90                  95      


Thr Leu Ser Lys Met Ile Leu Asp Arg Ala Pro Ala His Met Ser Lys 
            100                 105                 110         


Val Tyr Phe Gly Leu Ser Gly Ser Asp Ala Asn Glu Thr Asn Ile Lys 
        115                 120                 125             


Leu Ile Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Tyr His Gly Ser Gly Leu Met Thr Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Glu Leu Phe His Lys Lys Phe Asp Leu Pro Leu 
                165                 170                 175     


Ala Gln Val Ile His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Pro Asp 
            180                 185                 190         


Leu Ala Met Ser Glu Glu Ala Phe Ser Ala Tyr Cys Ala Ala Glu Leu 
        195                 200                 205             


Glu Gln Leu Ile Glu Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Val Leu Gly Thr Gly Gly Ile Val Pro Pro Pro Lys Gly 
225                 230                 235                 240 


Tyr Trp Glu Ala Ile Gln Pro Ile Leu Glu Lys His Asp Ile Leu Leu 
                245                 250                 255     


Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met Phe 
            260                 265                 270         


Gly Ser Asp His Tyr Gly Leu Lys Pro Asp Leu Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Ile Val Gly Asp 
    290                 295                 300                 


Lys Met Trp Lys Val Leu Glu Gln Gly Thr Asp Glu Asn Gly Pro Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Ile Asp Asp Met Asn Leu Val Ala Asn Ala 
            340                 345                 350         


Gly Glu Thr Gly Ala His Phe Arg Lys Ala Met Thr Asp Ala Leu Gly 
        355                 360                 365             


Asp His Ala Lys Val Gly Asp Ile Arg Gly Glu Gly Met Leu Cys Ala 
    370                 375                 380                 


Val Glu Leu Val Asp Asp Lys Asp Asn Arg Thr Phe Phe Asp Pro Ser 
385                 390                 395                 400 


Gln Lys Val Gly Ala Gln Ile Ala Ser Ala Leu Leu Ser Lys Gly Val 
                405                 410                 415     


Ile Ala Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro Pro 
            420                 425                 430         


Leu Cys Leu Thr Pro Ala Glu Ala Glu Glu Val Ala Thr Lys Thr Gly 
        435                 440                 445             


Glu Ala Val Arg Asp Val Leu Gly 
    450                 455     


<210>  12
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant transaminase

<400>  12

Met Leu Lys Asn Asp Gln Leu Asp Gln Trp Asp Arg Asp Asn Phe Phe 
1               5                   10                  15      


His Pro Ser Thr His Leu Ala Gln His Ala Arg Gly Glu Ser Ala Asn 
            20                  25                  30          


Arg Val Ile Lys Thr Ala Ser Gly Val Phe Ile Glu Asp Arg Asp Gly 
        35                  40                  45              


Thr Lys Leu Leu Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Gln Glu Ile Ala Glu Ala Ile Ala Asp Gln Ala Arg Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Ser Tyr Val Gly His Gly Thr Glu Ala Ser Ile 
                85                  90                  95      


Thr Leu Ala Lys Met Ile Leu Asp Arg Ala Pro Lys Asn Met Ser Lys 
            100                 105                 110         


Val Tyr Phe Gly Leu Gly Gly Ser Asp Ala Asn Glu Thr Asn Val Lys 
        115                 120                 125             


Leu Ile Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Tyr His Gly Ser Gly Leu Val Thr Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Glu Leu Phe His Lys Lys Phe Asp Leu Pro Val 
                165                 170                 175     


Glu Gln Val Ile His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Glu Asp 
            180                 185                 190         


Leu Asn Gln Thr Glu Glu Gln Phe Val Ala His Cys Val Ala Glu Leu 
        195                 200                 205             


Glu Ala Leu Ile Glu Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Ile Leu Gly Ala Gly Gly Ile Val Pro Pro Pro Ala Gly 
225                 230                 235                 240 


Tyr Trp Glu Ala Ile Gln Thr Val Leu Asn Lys His Asp Ile Leu Leu 
                245                 250                 255     


Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met Phe 
            260                 265                 270         


Gly Ser Asp His Tyr Gly Leu Glu Pro Asp Ile Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Ile Val Ser Asp 
    290                 295                 300                 


Lys Val Trp Lys Val Leu Glu Gln Gly Thr Asp Glu Asn Gly Pro Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Leu Asp Glu Leu Asn Leu Val Ser Asn Ala 
            340                 345                 350         


Gly Glu Val Gly Ala Tyr Leu Asn Ala Thr Met Ala Glu Ala Leu Ser 
        355                 360                 365             


Gln His Ala Asn Val Gly Asp Val Arg Gly Glu Gly Leu Leu Cys Ala 
    370                 375                 380                 


Val Glu Phe Val Lys Asp Arg Asp Ser Arg Thr Phe Phe Asp Ala Ala 
385                 390                 395                 400 


Asp Lys Ile Gly Pro Gln Ile Ser Ala Lys Leu Leu Glu Gln Asp Lys 
                405                 410                 415     


Ile Ile Ala Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Phe Cys Leu Thr Arg Ala Glu Ala Asp Gln Val Val Glu Gly Thr 
        435                 440                 445             


Leu Arg Ala Val Lys Ala Val Leu Gly 
    450                 455         


<210>  13
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  13

Met Leu Lys Asn Asp Gln Leu Asp Gln Trp Asp Arg Asp Asn Phe Phe 
1               5                   10                  15      


His Pro Ser Thr His Leu Ala Gln His Ala Arg Gly Glu Ser Ala Asn 
            20                  25                  30          


Arg Val Ile Lys Thr Ala Ser Gly Val Phe Ile Glu Asp Arg Asp Gly 
        35                  40                  45              


Thr Lys Leu Leu Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Gln Glu Ile Ala Glu Ala Ile Ala Asp Gln Ala Arg Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Ser Tyr Val Gly His Gly Thr Glu Ala Ser Ile 
                85                  90                  95      


Thr Leu Ala Lys Met Ile Leu Asp Arg Ala Pro Lys Asn Met Ser Lys 
            100                 105                 110         


Val Tyr Phe Gly Leu Gly Gly Ser Asp Ala Asn Glu Thr Asn Val Lys 
        115                 120                 125             


Leu Ile Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Tyr His Gly Ser Gly Leu Val Thr Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Glu Leu Phe His Lys Lys Phe Asp Leu Pro Val 
                165                 170                 175     


Glu Gln Val Ile His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Glu Asp 
            180                 185                 190         


Leu Asn Gln Thr Glu Glu Gln Phe Val Ala His Cys Val Ala Glu Leu 
        195                 200                 205             


Glu Ala Leu Ile Glu Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Ile Leu Gly Gly Gly Gly Ile Val Pro Pro Pro Ala Gly 
225                 230                 235                 240 


Tyr Trp Glu Ala Ile Gln Thr Val Leu Asn Lys His Asp Ile Leu Leu 
                245                 250                 255     


Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met Phe 
            260                 265                 270         


Gly Ser Asp His Tyr Gly Leu Glu Pro Asp Ile Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Ile Val Ser Asp 
    290                 295                 300                 


Lys Val Trp Lys Val Leu Glu Gln Gly Thr Asp Glu Asn Gly Pro Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Leu Asp Glu Leu Asn Leu Val Ser Asn Ala 
            340                 345                 350         


Gly Glu Val Gly Ala Tyr Leu Asn Ala Thr Met Ala Glu Ala Leu Ser 
        355                 360                 365             


Gln His Ala Asn Val Gly Asp Val Arg Gly Glu Gly Leu Leu Cys Ala 
    370                 375                 380                 


Val Glu Phe Val Lys Asp Arg Asp Ser Arg Thr Phe Phe Asp Ala Ala 
385                 390                 395                 400 


Asp Lys Ile Gly Pro Gln Ile Ser Ala Lys Leu Leu Glu Gln Asp Lys 
                405                 410                 415     


Ile Ile Ala Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Phe Cys Leu Thr Arg Ala Glu Ala Asp Gln Val Val Glu Gly Thr 
        435                 440                 445             


Leu Arg Ala Val Lys Ala Val Leu Gly 
    450                 455         


<210>  14
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  14

Met Leu Lys Asn Asp Gln Leu Asp Gln Trp Asp Arg Asp Asn Phe Phe 
1               5                   10                  15      


His Pro Ser Thr His Leu Ala Gln His Ala Arg Gly Glu Ser Ala Asn 
            20                  25                  30          


Arg Val Ile Lys Thr Ala Ser Gly Val Phe Ile Glu Asp Arg Asp Gly 
        35                  40                  45              


Thr Lys Leu Leu Asp Ala Phe Ala Gly Leu Phe Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Gln Glu Ile Ala Glu Ala Ile Ala Asp Gln Ala Arg Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Ser Tyr Val Gly His Gly Thr Glu Ala Ser Ile 
                85                  90                  95      


Thr Leu Ala Lys Met Ile Leu Asp Arg Ala Pro Lys Asn Met Ser Lys 
            100                 105                 110         


Val Tyr Phe Gly Leu Gly Gly Ser Asp Ala Asn Glu Thr Asn Val Lys 
        115                 120                 125             


Leu Ile Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Tyr His Gly Ser Gly Leu Val Thr Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Glu Leu Phe His Lys Lys Phe Asp Leu Pro Val 
                165                 170                 175     


Glu Gln Val Ile His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Glu Asp 
            180                 185                 190         


Leu Asn Gln Thr Glu Glu Gln Phe Val Ala His Cys Val Ala Glu Leu 
        195                 200                 205             


Glu Ala Leu Ile Glu Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Ile Leu Gly Ala Gly Gly Ile Val Pro Pro Pro Ala Gly 
225                 230                 235                 240 


Tyr Trp Glu Ala Ile Gln Thr Val Leu Asn Lys His Asp Ile Leu Leu 
                245                 250                 255     


Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met Phe 
            260                 265                 270         


Gly Ser Asp His Tyr Gly Leu Glu Pro Asp Ile Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Ile Val Ser Asp 
    290                 295                 300                 


Lys Val Trp Lys Val Leu Glu Gln Gly Thr Asp Glu Asn Gly Pro Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Leu Asp Glu Leu Asn Leu Val Ser Asn Ala 
            340                 345                 350         


Gly Glu Val Gly Ala Tyr Leu Asn Ala Thr Met Ala Glu Ala Leu Ser 
        355                 360                 365             


Gln His Ala Asn Val Gly Asp Val Arg Gly Glu Gly Leu Leu Cys Ala 
    370                 375                 380                 


Val Glu Phe Val Lys Asp Arg Asp Ser Arg Thr Phe Phe Asp Ala Ala 
385                 390                 395                 400 


Asp Lys Ile Gly Pro Gln Ile Ser Ala Lys Leu Leu Glu Gln Asp Lys 
                405                 410                 415     


Ile Ile Ala Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Phe Cys Leu Thr Arg Ala Glu Ala Asp Gln Val Val Glu Gly Thr 
        435                 440                 445             


Leu Arg Ala Val Lys Ala Val Leu Gly 
    450                 455         


<210>  15
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  15

Met Leu Asn Gln Ser Asn Glu Leu Asn Ala Trp Asp Arg Asp His Phe 
1               5                   10                  15      


Phe His Pro Ser Thr His Met Gly Thr His Ala Arg Gly Glu Ser Pro 
            20                  25                  30          


Thr Arg Ile Met Ala Gly Gly Glu Gly Val Thr Val Trp Asp Asn Asn 
        35                  40                  45              


Gly Arg Lys Ser Ile Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Val 
    50                  55                  60                  


Gly Tyr Gly Arg Gln Lys Ile Ala Asp Ala Ile Ala Thr Gln Ala Lys 
65                  70                  75                  80  


Asn Leu Ala Tyr Tyr His Ala Tyr Val Gly His Gly Thr Glu Ala Ser 
                85                  90                  95      


Ile Thr Leu Ala Lys Met Ile Ile Asp Arg Ala Pro Lys Gly Met Ser 
            100                 105                 110         


Arg Val Tyr Phe Gly Leu Ser Gly Ser Asp Ala Asn Glu Thr Asn Ile 
        115                 120                 125             


Lys Leu Ile Trp Tyr Tyr Asn Asn Val Leu Gly Arg Pro Glu Lys Lys 
    130                 135                 140                 


Lys Ile Ile Ser Arg Trp Arg Gly Tyr His Gly Ser Gly Val Met Thr 
145                 150                 155                 160 


Gly Ser Leu Thr Gly Leu Asp Leu Phe His Asn Ala Phe Asp Leu Pro 
                165                 170                 175     


Arg Ala Pro Val Leu His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Thr 
            180                 185                 190         


Asp Arg Ser Met Ser Glu Glu Gln Phe Ser Gln His Cys Ala Asp Lys 
        195                 200                 205             


Leu Glu Glu Met Ile Leu Ala Glu Gly Pro Glu Thr Ile Ala Ala Phe 
    210                 215                 220                 


Ile Gly Glu Pro Ile Leu Gly Ala Gly Gly Ile Val Pro Pro Pro Ala 
225                 230                 235                 240 


Gly Tyr Trp Glu Lys Ile Gln Ala Val Leu Lys Lys Tyr Asp Val Leu 
                245                 250                 255     


Leu Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met 
            260                 265                 270         


Phe Gly Ser Asp His Tyr Gly Ile Lys Pro Asp Leu Ile Thr Ile Ala 
        275                 280                 285             


Lys Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Val Ile Val Ala 
    290                 295                 300                 


Asp Arg Val Trp Gln Val Leu Val Gln Gly Ser Asp Lys Leu Gly Ser 
305                 310                 315                 320 


Leu Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Cys Val Ala Ala 
                325                 330                 335     


Gly Val Ala Asn Leu Glu Leu Ile Asp Glu Met Asp Leu Val Thr Asn 
            340                 345                 350         


Ala Gly Glu Thr Gly Ala Tyr Phe Arg Ala Glu Leu Ala Lys Ala Val 
        355                 360                 365             


Gly Gly His Lys Asn Val Gly Glu Val Arg Gly Asp Gly Met Leu Ala 
    370                 375                 380                 


Ala Val Glu Phe Val Ala Asp Lys Asp Asp Arg Val Phe Phe Asp Ala 
385                 390                 395                 400 


Ser Gln Lys Ile Gly Pro Gln Val Ala Thr Ala Leu Ala Ala Ser Gly 
                405                 410                 415     


Val Ile Gly Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Leu Cys Leu Thr Arg Glu Gln Ala Asp Ile Val Val Ser Lys Thr 
        435                 440                 445             


Ala Asp Ala Val Lys Ser Val Phe Ala Asn Leu 
    450                 455                 


<210>  16
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  16

Met Leu Asn Gln Ser Asn Glu Leu Asn Ala Trp Asp Arg Asp His Phe 
1               5                   10                  15      


Phe His Pro Ser Thr His Met Gly Thr His Ala Arg Gly Glu Ser Pro 
            20                  25                  30          


Thr Arg Ile Met Ala Gly Gly Glu Gly Val Thr Val Trp Asp Asn Asn 
        35                  40                  45              


Gly Arg Lys Ser Ile Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Val 
    50                  55                  60                  


Gly Tyr Gly Arg Gln Lys Ile Ala Asp Ala Ile Ala Thr Gln Ala Lys 
65                  70                  75                  80  


Asn Leu Ala Tyr Tyr His Ala Tyr Val Gly His Gly Thr Glu Ala Ser 
                85                  90                  95      


Ile Thr Leu Ala Lys Met Ile Ile Asp Arg Ala Pro Lys Gly Met Ser 
            100                 105                 110         


Arg Val Tyr Phe Gly Leu Ser Gly Ser Asp Ala Asn Glu Thr Asn Ile 
        115                 120                 125             


Lys Leu Ile Trp Tyr Tyr Asn Asn Val Leu Gly Arg Pro Glu Lys Lys 
    130                 135                 140                 


Lys Ile Ile Ser Arg Trp Arg Gly Tyr His Gly Ser Gly Val Met Thr 
145                 150                 155                 160 


Gly Ser Leu Thr Gly Leu Asp Leu Phe His Asn Ala Phe Asp Leu Pro 
                165                 170                 175     


Arg Ala Pro Val Leu His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Thr 
            180                 185                 190         


Asp Arg Ser Met Ser Glu Glu Gln Phe Ser Gln His Cys Ala Asp Lys 
        195                 200                 205             


Leu Glu Glu Met Ile Leu Ala Glu Gly Pro Glu Thr Ile Ala Ala Phe 
    210                 215                 220                 


Ile Gly Glu Pro Ile Leu Gly Gly Gly Gly Ile Val Pro Pro Pro Ala 
225                 230                 235                 240 


Gly Tyr Trp Glu Lys Ile Gln Ala Val Leu Lys Lys Tyr Asp Val Leu 
                245                 250                 255     


Leu Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met 
            260                 265                 270         


Phe Gly Ser Asp His Tyr Gly Ile Lys Pro Asp Leu Ile Thr Ile Ala 
        275                 280                 285             


Lys Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Val Ile Val Ala 
    290                 295                 300                 


Asp Arg Val Trp Gln Val Leu Val Gln Gly Ser Asp Lys Leu Gly Ser 
305                 310                 315                 320 


Leu Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Cys Val Ala Ala 
                325                 330                 335     


Gly Val Ala Asn Leu Glu Leu Ile Asp Glu Met Asp Leu Val Thr Asn 
            340                 345                 350         


Ala Gly Glu Thr Gly Ala Tyr Phe Arg Ala Glu Leu Ala Lys Ala Val 
        355                 360                 365             


Gly Gly His Lys Asn Val Gly Glu Val Arg Gly Asp Gly Met Leu Ala 
    370                 375                 380                 


Ala Val Glu Phe Val Ala Asp Lys Asp Asp Arg Val Phe Phe Asp Ala 
385                 390                 395                 400 


Ser Gln Lys Ile Gly Pro Gln Val Ala Thr Ala Leu Ala Ala Ser Gly 
                405                 410                 415     


Val Ile Gly Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Leu Cys Leu Thr Arg Glu Gln Ala Asp Ile Val Val Ser Lys Thr 
        435                 440                 445             


Ala Asp Ala Val Lys Ser Val Phe Ala Asn Leu 
    450                 455                 


<210>  17
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  17

Met Leu Asn Gln Ser Asn Glu Leu Asn Ala Trp Asp Arg Asp His Phe 
1               5                   10                  15      


Phe His Pro Ser Thr His Met Gly Thr His Ala Arg Gly Glu Ser Pro 
            20                  25                  30          


Thr Arg Ile Met Ala Gly Gly Glu Gly Val Thr Val Trp Asp Asn Asn 
        35                  40                  45              


Gly Arg Lys Ser Ile Asp Ala Phe Ala Gly Leu Phe Cys Val Asn Val 
    50                  55                  60                  


Gly Tyr Gly Arg Gln Lys Ile Ala Asp Ala Ile Ala Thr Gln Ala Lys 
65                  70                  75                  80  


Asn Leu Ala Tyr Tyr His Ala Tyr Val Gly His Gly Thr Glu Ala Ser 
                85                  90                  95      


Ile Thr Leu Ala Lys Met Ile Ile Asp Arg Ala Pro Lys Gly Met Ser 
            100                 105                 110         


Arg Val Tyr Phe Gly Leu Ser Gly Ser Asp Ala Asn Glu Thr Asn Ile 
        115                 120                 125             


Lys Leu Ile Trp Tyr Tyr Asn Asn Val Leu Gly Arg Pro Glu Lys Lys 
    130                 135                 140                 


Lys Ile Ile Ser Arg Trp Arg Gly Tyr His Gly Ser Gly Val Met Thr 
145                 150                 155                 160 


Gly Ser Leu Thr Gly Leu Asp Leu Phe His Asn Ala Phe Asp Leu Pro 
                165                 170                 175     


Arg Ala Pro Val Leu His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Thr 
            180                 185                 190         


Asp Arg Ser Met Ser Glu Glu Gln Phe Ser Gln His Cys Ala Asp Lys 
        195                 200                 205             


Leu Glu Glu Met Ile Leu Ala Glu Gly Pro Glu Thr Ile Ala Ala Phe 
    210                 215                 220                 


Ile Gly Glu Pro Ile Leu Gly Ala Gly Gly Ile Val Pro Pro Pro Ala 
225                 230                 235                 240 


Gly Tyr Trp Glu Lys Ile Gln Ala Val Leu Lys Lys Tyr Asp Val Leu 
                245                 250                 255     


Leu Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met 
            260                 265                 270         


Phe Gly Ser Asp His Tyr Gly Ile Lys Pro Asp Leu Ile Thr Ile Ala 
        275                 280                 285             


Lys Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Val Ile Val Ala 
    290                 295                 300                 


Asp Arg Val Trp Gln Val Leu Val Gln Gly Ser Asp Lys Leu Gly Ser 
305                 310                 315                 320 


Leu Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Cys Val Ala Ala 
                325                 330                 335     


Gly Val Ala Asn Leu Glu Leu Ile Asp Glu Met Asp Leu Val Thr Asn 
            340                 345                 350         


Ala Gly Glu Thr Gly Ala Tyr Phe Arg Ala Glu Leu Ala Lys Ala Val 
        355                 360                 365             


Gly Gly His Lys Asn Val Gly Glu Val Arg Gly Asp Gly Met Leu Ala 
    370                 375                 380                 


Ala Val Glu Phe Val Ala Asp Lys Asp Asp Arg Val Phe Phe Asp Ala 
385                 390                 395                 400 


Ser Gln Lys Ile Gly Pro Gln Val Ala Thr Ala Leu Ala Ala Ser Gly 
                405                 410                 415     


Val Ile Gly Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Leu Cys Leu Thr Arg Glu Gln Ala Asp Ile Val Val Ser Lys Thr 
        435                 440                 445             


Ala Asp Ala Val Lys Ser Val Phe Ala Asn Leu 
    450                 455                 


<210>  18
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  18

Met Leu Lys Asn Asp Gln Leu Asp Gln Trp Asp Arg Asp Asn Phe Phe 
1               5                   10                  15      


His Pro Ser Thr His Leu Ala Gln His Ala Arg Gly Glu Ser Ala Asn 
            20                  25                  30          


Arg Val Ile Lys Thr Ala Ser Gly Val Phe Ile Glu Asp Arg Asp Gly 
        35                  40                  45              


Thr Lys Leu Leu Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Gln Glu Ile Ala Glu Ala Ile Ala Asp Gln Ala Arg Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Ser Phe Val Gly His Gly Thr Glu Ala Ser Ile 
                85                  90                  95      


Thr Leu Ala Lys Met Ile Leu Asp Arg Ala Pro Lys Asn Met Ser Lys 
            100                 105                 110         


Val Tyr Phe Gly Leu Gly Gly Ser Asp Ala Asn Glu Thr Asn Val Lys 
        115                 120                 125             


Leu Ile Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Tyr His Gly Ser Gly Leu Val Thr Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Glu Leu Phe His Lys Lys Phe Asp Leu Pro Val 
                165                 170                 175     


Glu Gln Val Ile His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Glu Asp 
            180                 185                 190         


Leu Asn Gln Thr Glu Glu Gln Phe Val Ala His Cys Val Ala Glu Leu 
        195                 200                 205             


Glu Ala Leu Ile Glu Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Ile Leu Gly Ala Gly Gly Ile Val Pro Pro Pro Ala Gly 
225                 230                 235                 240 


Tyr Trp Glu Ala Ile Gln Thr Val Leu Asn Lys His Asp Ile Leu Leu 
                245                 250                 255     


Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met Phe 
            260                 265                 270         


Gly Ser Asp His Tyr Gly Leu Glu Pro Asp Ile Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Ile Val Ser Asp 
    290                 295                 300                 


Lys Val Trp Lys Val Leu Glu Gln Gly Thr Asp Glu Asn Gly Pro Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Leu Asp Glu Leu Asn Leu Val Ser Asn Ala 
            340                 345                 350         


Gly Glu Val Gly Ala Tyr Leu Asn Ala Thr Met Ala Glu Ala Leu Ser 
        355                 360                 365             


Gln His Ala Asn Val Gly Asp Val Arg Gly Glu Gly Leu Leu Cys Ala 
    370                 375                 380                 


Val Glu Phe Val Lys Asp Arg Asp Ser Arg Thr Phe Phe Asp Ala Ala 
385                 390                 395                 400 


Asp Lys Ile Gly Pro Gln Ile Ser Ala Lys Leu Leu Glu Gln Asp Lys 
                405                 410                 415     


Ile Ile Ala Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Phe Cys Leu Thr Arg Ala Glu Ala Asp Gln Val Val Glu Gly Thr 
        435                 440                 445             


Leu Arg Ala Val Lys Ala Val Leu Gly 
    450                 455         


<210>  19
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  19

Met Leu Lys Asn Asp Gln Leu Asp Gln Trp Asp Arg Asp Asn Phe Phe 
1               5                   10                  15      


His Pro Ser Thr His Leu Ala Gln His Ala Arg Gly Glu Ser Ala Asn 
            20                  25                  30          


Arg Val Ile Lys Thr Ala Ser Gly Val Phe Ile Glu Asp Arg Asp Gly 
        35                  40                  45              


Thr Lys Leu Leu Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Gln Glu Ile Ala Glu Ala Ile Ala Asp Gln Ala Arg Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Ser Leu Val Gly His Gly Thr Glu Ala Ser Ile 
                85                  90                  95      


Thr Leu Ala Lys Met Ile Leu Asp Arg Ala Pro Lys Asn Met Ser Lys 
            100                 105                 110         


Val Tyr Phe Gly Leu Gly Gly Ser Asp Ala Asn Glu Thr Asn Val Lys 
        115                 120                 125             


Leu Ile Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Tyr His Gly Ser Gly Leu Val Thr Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Glu Leu Phe His Lys Lys Phe Asp Leu Pro Val 
                165                 170                 175     


Glu Gln Val Ile His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Glu Asp 
            180                 185                 190         


Leu Asn Gln Thr Glu Glu Gln Phe Val Ala His Cys Val Ala Glu Leu 
        195                 200                 205             


Glu Ala Leu Ile Glu Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Ile Leu Gly Ala Gly Gly Ile Val Pro Pro Pro Ala Gly 
225                 230                 235                 240 


Tyr Trp Glu Ala Ile Gln Thr Val Leu Asn Lys His Asp Ile Leu Leu 
                245                 250                 255     


Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met Phe 
            260                 265                 270         


Gly Ser Asp His Tyr Gly Leu Glu Pro Asp Ile Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Ile Val Ser Asp 
    290                 295                 300                 


Lys Val Trp Lys Val Leu Glu Gln Gly Thr Asp Glu Asn Gly Pro Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Leu Asp Glu Leu Asn Leu Val Ser Asn Ala 
            340                 345                 350         


Gly Glu Val Gly Ala Tyr Leu Asn Ala Thr Met Ala Glu Ala Leu Ser 
        355                 360                 365             


Gln His Ala Asn Val Gly Asp Val Arg Gly Glu Gly Leu Leu Cys Ala 
    370                 375                 380                 


Val Glu Phe Val Lys Asp Arg Asp Ser Arg Thr Phe Phe Asp Ala Ala 
385                 390                 395                 400 


Asp Lys Ile Gly Pro Gln Ile Ser Ala Lys Leu Leu Glu Gln Asp Lys 
                405                 410                 415     


Ile Ile Ala Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Phe Cys Leu Thr Arg Ala Glu Ala Asp Gln Val Val Glu Gly Thr 
        435                 440                 445             


Leu Arg Ala Val Lys Ala Val Leu Gly 
    450                 455         


<210>  20
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  20

Met Leu Lys Asn Asp Gln Leu Asp Gln Trp Asp Arg Asp Asn Phe Phe 
1               5                   10                  15      


His Pro Ser Thr His Leu Ala Gln His Ala Arg Gly Glu Ser Ala Asn 
            20                  25                  30          


Arg Val Ile Lys Thr Ala Ser Gly Val Phe Ile Glu Asp Arg Asp Gly 
        35                  40                  45              


Thr Lys Leu Leu Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Gln Glu Ile Ala Glu Ala Ile Ala Asp Gln Ala Arg Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Ser Val Val Gly His Gly Thr Glu Ala Ser Ile 
                85                  90                  95      


Thr Leu Ala Lys Met Ile Leu Asp Arg Ala Pro Lys Asn Met Ser Lys 
            100                 105                 110         


Val Tyr Phe Gly Leu Gly Gly Ser Asp Ala Asn Glu Thr Asn Val Lys 
        115                 120                 125             


Leu Ile Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Tyr His Gly Ser Gly Leu Val Thr Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Glu Leu Phe His Lys Lys Phe Asp Leu Pro Val 
                165                 170                 175     


Glu Gln Val Ile His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Glu Asp 
            180                 185                 190         


Leu Asn Gln Thr Glu Glu Gln Phe Val Ala His Cys Val Ala Glu Leu 
        195                 200                 205             


Glu Ala Leu Ile Glu Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Ile Leu Gly Ala Gly Gly Ile Val Pro Pro Pro Ala Gly 
225                 230                 235                 240 


Tyr Trp Glu Ala Ile Gln Thr Val Leu Asn Lys His Asp Ile Leu Leu 
                245                 250                 255     


Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met Phe 
            260                 265                 270         


Gly Ser Asp His Tyr Gly Leu Glu Pro Asp Ile Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Ile Val Ser Asp 
    290                 295                 300                 


Lys Val Trp Lys Val Leu Glu Gln Gly Thr Asp Glu Asn Gly Pro Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Leu Asp Glu Leu Asn Leu Val Ser Asn Ala 
            340                 345                 350         


Gly Glu Val Gly Ala Tyr Leu Asn Ala Thr Met Ala Glu Ala Leu Ser 
        355                 360                 365             


Gln His Ala Asn Val Gly Asp Val Arg Gly Glu Gly Leu Leu Cys Ala 
    370                 375                 380                 


Val Glu Phe Val Lys Asp Arg Asp Ser Arg Thr Phe Phe Asp Ala Ala 
385                 390                 395                 400 


Asp Lys Ile Gly Pro Gln Ile Ser Ala Lys Leu Leu Glu Gln Asp Lys 
                405                 410                 415     


Ile Ile Ala Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Phe Cys Leu Thr Arg Ala Glu Ala Asp Gln Val Val Glu Gly Thr 
        435                 440                 445             


Leu Arg Ala Val Lys Ala Val Leu Gly 
    450                 455         


<210>  21
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  21

Met Leu Lys Asn Asp Gln Leu Asp Gln Trp Asp Arg Asp Asn Phe Phe 
1               5                   10                  15      


His Pro Ser Thr His Leu Ala Gln His Ala Arg Gly Glu Ser Ala Asn 
            20                  25                  30          


Arg Val Ile Lys Thr Ala Ser Gly Val Phe Ile Glu Asp Arg Asp Gly 
        35                  40                  45              


Thr Lys Leu Leu Asp Ala Phe Ala Gly Leu Phe Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Gln Glu Ile Ala Glu Ala Ile Ala Asp Gln Ala Arg Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Ser Tyr Val Gly His Gly Thr Glu Ala Ser Ile 
                85                  90                  95      


Thr Leu Ala Lys Met Ile Leu Asp Arg Ala Pro Lys Asn Met Ser Lys 
            100                 105                 110         


Val Tyr Phe Gly Leu Gly Gly Ser Asp Ala Asn Glu Thr Asn Val Lys 
        115                 120                 125             


Leu Ile Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Phe His Gly Ser Gly Leu Val Thr Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Glu Leu Phe His Lys Lys Phe Asp Leu Pro Val 
                165                 170                 175     


Glu Gln Val Ile His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Glu Asp 
            180                 185                 190         


Leu Asn Gln Thr Glu Glu Gln Phe Val Ala His Cys Val Ala Glu Leu 
        195                 200                 205             


Glu Ala Leu Ile Glu Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Ile Leu Gly Gly Gly Gly Ile Val Pro Pro Pro Ala Gly 
225                 230                 235                 240 


Tyr Trp Glu Ala Ile Gln Thr Val Leu Asn Lys His Asp Ile Leu Leu 
                245                 250                 255     


Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met Phe 
            260                 265                 270         


Gly Ser Asp His Tyr Gly Leu Glu Pro Asp Ile Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Ile Val Ser Asp 
    290                 295                 300                 


Lys Val Trp Lys Val Leu Glu Gln Gly Thr Asp Glu Asn Gly Pro Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Leu Asp Glu Leu Asn Leu Val Ser Asn Ala 
            340                 345                 350         


Gly Glu Val Gly Ala Tyr Leu Asn Ala Thr Met Ala Glu Ala Leu Ser 
        355                 360                 365             


Gln His Ala Asn Val Gly Asp Val Arg Gly Glu Gly Leu Leu Cys Ala 
    370                 375                 380                 


Val Glu Phe Val Lys Asp Arg Asp Ser Arg Thr Phe Phe Asp Ala Ala 
385                 390                 395                 400 


Asp Lys Ile Gly Pro Gln Ile Ser Ala Lys Leu Leu Glu Gln Asp Lys 
                405                 410                 415     


Ile Ile Ala Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Phe Cys Leu Thr Arg Ala Glu Ala Asp Gln Val Val Glu Gly Thr 
        435                 440                 445             


Leu Arg Ala Val Lys Ala Val Leu Gly 
    450                 455         


<210>  22
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  22

Met Leu Lys Asn Asp Gln Leu Asp Gln Trp Asp Arg Asp Asn Phe Phe 
1               5                   10                  15      


His Pro Ser Thr His Leu Ala Gln His Ala Arg Gly Glu Ser Ala Asn 
            20                  25                  30          


Arg Val Ile Lys Thr Ala Ser Gly Val Phe Ile Glu Asp Arg Asp Gly 
        35                  40                  45              


Thr Lys Leu Leu Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Gln Glu Ile Ala Glu Ala Ile Ala Asp Gln Ala Arg Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Ser Tyr Val Gly His Gly Thr Glu Ala Ser Ile 
                85                  90                  95      


Thr Leu Ala Lys Met Ile Leu Asp Arg Ala Pro Lys Asn Met Ser Lys 
            100                 105                 110         


Val Tyr Phe Gly Leu Gly Gly Ser Asp Ala Asn Glu Thr Asn Val Lys 
        115                 120                 125             


Leu Ile Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Tyr His Gly Ser Gly Leu Val Thr Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Glu Leu Phe His Lys Lys Phe Asp Leu Pro Val 
                165                 170                 175     


Glu Gln Val Ile His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Glu Asp 
            180                 185                 190         


Leu Asn Gln Thr Glu Glu Gln Phe Val Ala His Cys Val Ala Glu Leu 
        195                 200                 205             


Glu Ala Leu Ile Glu Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Ile Leu Gly Ala Gly Gly Phe Val Pro Pro Pro Ala Gly 
225                 230                 235                 240 


Tyr Trp Glu Ala Ile Gln Thr Val Leu Asn Lys His Asp Ile Leu Leu 
                245                 250                 255     


Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met Phe 
            260                 265                 270         


Gly Ser Asp His Tyr Gly Leu Glu Pro Asp Ile Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Ile Val Ser Asp 
    290                 295                 300                 


Lys Val Trp Lys Val Leu Glu Gln Gly Thr Asp Glu Asn Gly Pro Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Leu Asp Glu Leu Asn Leu Val Ser Asn Ala 
            340                 345                 350         


Gly Glu Val Gly Ala Tyr Leu Asn Ala Thr Met Ala Glu Ala Leu Ser 
        355                 360                 365             


Gln His Ala Asn Val Gly Asp Val Arg Gly Glu Gly Leu Leu Cys Ala 
    370                 375                 380                 


Val Glu Phe Val Lys Asp Arg Asp Ser Arg Thr Phe Phe Asp Ala Ala 
385                 390                 395                 400 


Asp Lys Ile Gly Pro Gln Ile Ser Ala Lys Leu Leu Glu Gln Asp Lys 
                405                 410                 415     


Ile Ile Ala Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Phe Cys Leu Thr Arg Ala Glu Ala Asp Gln Val Val Glu Gly Thr 
        435                 440                 445             


Leu Arg Ala Val Lys Ala Val Leu Gly 
    450                 455         


<210>  23
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  23

Met Leu Lys Asn Asp Gln Leu Asp Gln Trp Asp Arg Asp Asn Phe Phe 
1               5                   10                  15      


His Pro Ser Thr His Leu Ala Gln His Ala Arg Gly Glu Ser Ala Asn 
            20                  25                  30          


Arg Val Ile Lys Thr Ala Ser Gly Val Phe Ile Glu Asp Arg Asp Gly 
        35                  40                  45              


Thr Lys Leu Leu Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Gln Glu Ile Ala Glu Ala Ile Ala Asp Gln Ala Arg Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Ser Tyr Val Gly His Gly Thr Glu Ala Ser Ile 
                85                  90                  95      


Thr Leu Ala Lys Met Ile Leu Asp Arg Ala Pro Lys Asn Met Ser Lys 
            100                 105                 110         


Val Tyr Phe Gly Leu Gly Gly Ser Asp Ala Asn Glu Thr Asn Val Lys 
        115                 120                 125             


Leu Ile Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Tyr His Gly Ser Gly Leu Val Thr Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Glu Leu Phe His Lys Lys Phe Asp Leu Pro Val 
                165                 170                 175     


Glu Gln Val Ile His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Glu Asp 
            180                 185                 190         


Leu Asn Gln Thr Glu Glu Gln Phe Val Ala His Cys Val Ala Glu Leu 
        195                 200                 205             


Glu Ala Leu Ile Glu Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Ile Leu Gly Ala Gly Gly Met Val Pro Pro Pro Ala Gly 
225                 230                 235                 240 


Tyr Trp Glu Ala Ile Gln Thr Val Leu Asn Lys His Asp Ile Leu Leu 
                245                 250                 255     


Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met Phe 
            260                 265                 270         


Gly Ser Asp His Tyr Gly Leu Glu Pro Asp Ile Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Ile Val Ser Asp 
    290                 295                 300                 


Lys Val Trp Lys Val Leu Glu Gln Gly Thr Asp Glu Asn Gly Pro Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Leu Asp Glu Leu Asn Leu Val Ser Asn Ala 
            340                 345                 350         


Gly Glu Val Gly Ala Tyr Leu Asn Ala Thr Met Ala Glu Ala Leu Ser 
        355                 360                 365             


Gln His Ala Asn Val Gly Asp Val Arg Gly Glu Gly Leu Leu Cys Ala 
    370                 375                 380                 


Val Glu Phe Val Lys Asp Arg Asp Ser Arg Thr Phe Phe Asp Ala Ala 
385                 390                 395                 400 


Asp Lys Ile Gly Pro Gln Ile Ser Ala Lys Leu Leu Glu Gln Asp Lys 
                405                 410                 415     


Ile Ile Ala Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Phe Cys Leu Thr Arg Ala Glu Ala Asp Gln Val Val Glu Gly Thr 
        435                 440                 445             


Leu Arg Ala Val Lys Ala Val Leu Gly 
    450                 455         


<210>  24
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  24

Met Leu Asn Gln Ser Asn Glu Leu Asn Ala Trp Asp Arg Asp His Phe 
1               5                   10                  15      


Phe His Pro Ser Thr His Met Gly Thr His Ala Arg Gly Glu Ser Pro 
            20                  25                  30          


Thr Arg Ile Met Ala Gly Gly Glu Gly Val Thr Val Trp Asp Asn Asn 
        35                  40                  45              


Gly Arg Lys Ser Ile Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Val 
    50                  55                  60                  


Gly Tyr Gly Arg Gln Lys Ile Ala Asp Ala Ile Ala Thr Gln Ala Lys 
65                  70                  75                  80  


Asn Leu Ala Tyr Tyr His Ala Phe Val Gly His Gly Thr Glu Ala Ser 
                85                  90                  95      


Ile Thr Leu Ala Lys Met Ile Ile Asp Arg Ala Pro Lys Gly Met Ser 
            100                 105                 110         


Arg Val Tyr Phe Gly Leu Ser Gly Ser Asp Ala Asn Glu Thr Asn Ile 
        115                 120                 125             


Lys Leu Ile Trp Tyr Tyr Asn Asn Val Leu Gly Arg Pro Glu Lys Lys 
    130                 135                 140                 


Lys Ile Ile Ser Arg Trp Arg Gly Tyr His Gly Ser Gly Val Met Thr 
145                 150                 155                 160 


Gly Ser Leu Thr Gly Leu Asp Leu Phe His Asn Ala Phe Asp Leu Pro 
                165                 170                 175     


Arg Ala Pro Val Leu His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Thr 
            180                 185                 190         


Asp Arg Ser Met Ser Glu Glu Gln Phe Ser Gln His Cys Ala Asp Lys 
        195                 200                 205             


Leu Glu Glu Met Ile Leu Ala Glu Gly Pro Glu Thr Ile Ala Ala Phe 
    210                 215                 220                 


Ile Gly Glu Pro Ile Leu Gly Ala Gly Gly Ile Val Pro Pro Pro Ala 
225                 230                 235                 240 


Gly Tyr Trp Glu Lys Ile Gln Ala Val Leu Lys Lys Tyr Asp Val Leu 
                245                 250                 255     


Leu Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met 
            260                 265                 270         


Phe Gly Ser Asp His Tyr Gly Ile Lys Pro Asp Leu Ile Thr Ile Ala 
        275                 280                 285             


Lys Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Val Ile Val Ala 
    290                 295                 300                 


Asp Arg Val Trp Gln Val Leu Val Gln Gly Ser Asp Lys Leu Gly Ser 
305                 310                 315                 320 


Leu Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Cys Val Ala Ala 
                325                 330                 335     


Gly Val Ala Asn Leu Glu Leu Ile Asp Glu Met Asp Leu Val Thr Asn 
            340                 345                 350         


Ala Gly Glu Thr Gly Ala Tyr Phe Arg Ala Glu Leu Ala Lys Ala Val 
        355                 360                 365             


Gly Gly His Lys Asn Val Gly Glu Val Arg Gly Asp Gly Met Leu Ala 
    370                 375                 380                 


Ala Val Glu Phe Val Ala Asp Lys Asp Asp Arg Val Phe Phe Asp Ala 
385                 390                 395                 400 


Ser Gln Lys Ile Gly Pro Gln Val Ala Thr Ala Leu Ala Ala Ser Gly 
                405                 410                 415     


Val Ile Gly Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Leu Cys Leu Thr Arg Glu Gln Ala Asp Ile Val Val Ser Lys Thr 
        435                 440                 445             


Ala Asp Ala Val Lys Ser Val Phe Ala Asn Leu 
    450                 455                 


<210>  25
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  25

Met Leu Asn Gln Ser Asn Glu Leu Asn Ala Trp Asp Arg Asp His Phe 
1               5                   10                  15      


Phe His Pro Ser Thr His Met Gly Thr His Ala Arg Gly Glu Ser Pro 
            20                  25                  30          


Thr Arg Ile Met Ala Gly Gly Glu Gly Val Thr Val Trp Asp Asn Asn 
        35                  40                  45              


Gly Arg Lys Ser Ile Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Val 
    50                  55                  60                  


Gly Tyr Gly Arg Gln Lys Ile Ala Asp Ala Ile Ala Thr Gln Ala Lys 
65                  70                  75                  80  


Asn Leu Ala Tyr Tyr His Ala Leu Val Gly His Gly Thr Glu Ala Ser 
                85                  90                  95      


Ile Thr Leu Ala Lys Met Ile Ile Asp Arg Ala Pro Lys Gly Met Ser 
            100                 105                 110         


Arg Val Tyr Phe Gly Leu Ser Gly Ser Asp Ala Asn Glu Thr Asn Ile 
        115                 120                 125             


Lys Leu Ile Trp Tyr Tyr Asn Asn Val Leu Gly Arg Pro Glu Lys Lys 
    130                 135                 140                 


Lys Ile Ile Ser Arg Trp Arg Gly Tyr His Gly Ser Gly Val Met Thr 
145                 150                 155                 160 


Gly Ser Leu Thr Gly Leu Asp Leu Phe His Asn Ala Phe Asp Leu Pro 
                165                 170                 175     


Arg Ala Pro Val Leu His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Thr 
            180                 185                 190         


Asp Arg Ser Met Ser Glu Glu Gln Phe Ser Gln His Cys Ala Asp Lys 
        195                 200                 205             


Leu Glu Glu Met Ile Leu Ala Glu Gly Pro Glu Thr Ile Ala Ala Phe 
    210                 215                 220                 


Ile Gly Glu Pro Ile Leu Gly Ala Gly Gly Ile Val Pro Pro Pro Ala 
225                 230                 235                 240 


Gly Tyr Trp Glu Lys Ile Gln Ala Val Leu Lys Lys Tyr Asp Val Leu 
                245                 250                 255     


Leu Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met 
            260                 265                 270         


Phe Gly Ser Asp His Tyr Gly Ile Lys Pro Asp Leu Ile Thr Ile Ala 
        275                 280                 285             


Lys Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Val Ile Val Ala 
    290                 295                 300                 


Asp Arg Val Trp Gln Val Leu Val Gln Gly Ser Asp Lys Leu Gly Ser 
305                 310                 315                 320 


Leu Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Cys Val Ala Ala 
                325                 330                 335     


Gly Val Ala Asn Leu Glu Leu Ile Asp Glu Met Asp Leu Val Thr Asn 
            340                 345                 350         


Ala Gly Glu Thr Gly Ala Tyr Phe Arg Ala Glu Leu Ala Lys Ala Val 
        355                 360                 365             


Gly Gly His Lys Asn Val Gly Glu Val Arg Gly Asp Gly Met Leu Ala 
    370                 375                 380                 


Ala Val Glu Phe Val Ala Asp Lys Asp Asp Arg Val Phe Phe Asp Ala 
385                 390                 395                 400 


Ser Gln Lys Ile Gly Pro Gln Val Ala Thr Ala Leu Ala Ala Ser Gly 
                405                 410                 415     


Val Ile Gly Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Leu Cys Leu Thr Arg Glu Gln Ala Asp Ile Val Val Ser Lys Thr 
        435                 440                 445             


Ala Asp Ala Val Lys Ser Val Phe Ala Asn Leu 
    450                 455                 


<210>  26
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  26

Met Leu Asn Gln Ser Asn Glu Leu Asn Ala Trp Asp Arg Asp His Phe 
1               5                   10                  15      


Phe His Pro Ser Thr His Met Gly Thr His Ala Arg Gly Glu Ser Pro 
            20                  25                  30          


Thr Arg Ile Met Ala Gly Gly Glu Gly Val Thr Val Trp Asp Asn Asn 
        35                  40                  45              


Gly Arg Lys Ser Ile Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Val 
    50                  55                  60                  


Gly Tyr Gly Arg Gln Lys Ile Ala Asp Ala Ile Ala Thr Gln Ala Lys 
65                  70                  75                  80  


Asn Leu Ala Tyr Tyr His Ala Val Val Gly His Gly Thr Glu Ala Ser 
                85                  90                  95      


Ile Thr Leu Ala Lys Met Ile Ile Asp Arg Ala Pro Lys Gly Met Ser 
            100                 105                 110         


Arg Val Tyr Phe Gly Leu Ser Gly Ser Asp Ala Asn Glu Thr Asn Ile 
        115                 120                 125             


Lys Leu Ile Trp Tyr Tyr Asn Asn Val Leu Gly Arg Pro Glu Lys Lys 
    130                 135                 140                 


Lys Ile Ile Ser Arg Trp Arg Gly Tyr His Gly Ser Gly Val Met Thr 
145                 150                 155                 160 


Gly Ser Leu Thr Gly Leu Asp Leu Phe His Asn Ala Phe Asp Leu Pro 
                165                 170                 175     


Arg Ala Pro Val Leu His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Thr 
            180                 185                 190         


Asp Arg Ser Met Ser Glu Glu Gln Phe Ser Gln His Cys Ala Asp Lys 
        195                 200                 205             


Leu Glu Glu Met Ile Leu Ala Glu Gly Pro Glu Thr Ile Ala Ala Phe 
    210                 215                 220                 


Ile Gly Glu Pro Ile Leu Gly Ala Gly Gly Ile Val Pro Pro Pro Ala 
225                 230                 235                 240 


Gly Tyr Trp Glu Lys Ile Gln Ala Val Leu Lys Lys Tyr Asp Val Leu 
                245                 250                 255     


Leu Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met 
            260                 265                 270         


Phe Gly Ser Asp His Tyr Gly Ile Lys Pro Asp Leu Ile Thr Ile Ala 
        275                 280                 285             


Lys Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Val Ile Val Ala 
    290                 295                 300                 


Asp Arg Val Trp Gln Val Leu Val Gln Gly Ser Asp Lys Leu Gly Ser 
305                 310                 315                 320 


Leu Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Cys Val Ala Ala 
                325                 330                 335     


Gly Val Ala Asn Leu Glu Leu Ile Asp Glu Met Asp Leu Val Thr Asn 
            340                 345                 350         


Ala Gly Glu Thr Gly Ala Tyr Phe Arg Ala Glu Leu Ala Lys Ala Val 
        355                 360                 365             


Gly Gly His Lys Asn Val Gly Glu Val Arg Gly Asp Gly Met Leu Ala 
    370                 375                 380                 


Ala Val Glu Phe Val Ala Asp Lys Asp Asp Arg Val Phe Phe Asp Ala 
385                 390                 395                 400 


Ser Gln Lys Ile Gly Pro Gln Val Ala Thr Ala Leu Ala Ala Ser Gly 
                405                 410                 415     


Val Ile Gly Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Leu Cys Leu Thr Arg Glu Gln Ala Asp Ile Val Val Ser Lys Thr 
        435                 440                 445             


Ala Asp Ala Val Lys Ser Val Phe Ala Asn Leu 
    450                 455                 


<210>  27
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  27

Met Leu Asn Gln Ser Asn Glu Leu Asn Ala Trp Asp Arg Asp His Phe 
1               5                   10                  15      


Phe His Pro Ser Thr His Met Gly Thr His Ala Arg Gly Glu Ser Pro 
            20                  25                  30          


Thr Arg Ile Met Ala Gly Gly Glu Gly Val Thr Val Trp Asp Asn Asn 
        35                  40                  45              


Gly Arg Lys Ser Ile Asp Ala Phe Ala Gly Leu Phe Cys Val Asn Val 
    50                  55                  60                  


Gly Tyr Gly Arg Gln Lys Ile Ala Asp Ala Ile Ala Thr Gln Ala Lys 
65                  70                  75                  80  


Asn Leu Ala Tyr Tyr His Ala Tyr Val Gly His Gly Thr Glu Ala Ser 
                85                  90                  95      


Ile Thr Leu Ala Lys Met Ile Ile Asp Arg Ala Pro Lys Gly Met Ser 
            100                 105                 110         


Arg Val Tyr Phe Gly Leu Ser Gly Ser Asp Ala Asn Glu Thr Asn Ile 
        115                 120                 125             


Lys Leu Ile Trp Tyr Tyr Asn Asn Val Leu Gly Arg Pro Glu Lys Lys 
    130                 135                 140                 


Lys Ile Ile Ser Arg Trp Arg Gly Phe His Gly Ser Gly Val Met Thr 
145                 150                 155                 160 


Gly Ser Leu Thr Gly Leu Asp Leu Phe His Asn Ala Phe Asp Leu Pro 
                165                 170                 175     


Arg Ala Pro Val Leu His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Thr 
            180                 185                 190         


Asp Arg Ser Met Ser Glu Glu Gln Phe Ser Gln His Cys Ala Asp Lys 
        195                 200                 205             


Leu Glu Glu Met Ile Leu Ala Glu Gly Pro Glu Thr Ile Ala Ala Phe 
    210                 215                 220                 


Ile Gly Glu Pro Ile Leu Gly Gly Gly Gly Ile Val Pro Pro Pro Ala 
225                 230                 235                 240 


Gly Tyr Trp Glu Lys Ile Gln Ala Val Leu Lys Lys Tyr Asp Val Leu 
                245                 250                 255     


Leu Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met 
            260                 265                 270         


Phe Gly Ser Asp His Tyr Gly Ile Lys Pro Asp Leu Ile Thr Ile Ala 
        275                 280                 285             


Lys Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Val Ile Val Ala 
    290                 295                 300                 


Asp Arg Val Trp Gln Val Leu Val Gln Gly Ser Asp Lys Leu Gly Ser 
305                 310                 315                 320 


Leu Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Cys Val Ala Ala 
                325                 330                 335     


Gly Val Ala Asn Leu Glu Leu Ile Asp Glu Met Asp Leu Val Thr Asn 
            340                 345                 350         


Ala Gly Glu Thr Gly Ala Tyr Phe Arg Ala Glu Leu Ala Lys Ala Val 
        355                 360                 365             


Gly Gly His Lys Asn Val Gly Glu Val Arg Gly Asp Gly Met Leu Ala 
    370                 375                 380                 


Ala Val Glu Phe Val Ala Asp Lys Asp Asp Arg Val Phe Phe Asp Ala 
385                 390                 395                 400 


Ser Gln Lys Ile Gly Pro Gln Val Ala Thr Ala Leu Ala Ala Ser Gly 
                405                 410                 415     


Val Ile Gly Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Leu Cys Leu Thr Arg Glu Gln Ala Asp Ile Val Val Ser Lys Thr 
        435                 440                 445             


Ala Asp Ala Val Lys Ser Val Phe Ala Asn Leu 
    450                 455                 


<210>  28
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  28

Met Leu Asn Gln Ser Asn Glu Leu Asn Ala Trp Asp Arg Asp His Phe 
1               5                   10                  15      


Phe His Pro Ser Thr His Met Gly Thr His Ala Arg Gly Glu Ser Pro 
            20                  25                  30          


Thr Arg Ile Met Ala Gly Gly Glu Gly Val Thr Val Trp Asp Asn Asn 
        35                  40                  45              


Gly Arg Lys Ser Ile Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Val 
    50                  55                  60                  


Gly Tyr Gly Arg Gln Lys Ile Ala Asp Ala Ile Ala Thr Gln Ala Lys 
65                  70                  75                  80  


Asn Leu Ala Tyr Tyr His Ala Tyr Val Gly His Gly Thr Glu Ala Ser 
                85                  90                  95      


Ile Thr Leu Ala Lys Met Ile Ile Asp Arg Ala Pro Lys Gly Met Ser 
            100                 105                 110         


Arg Val Tyr Phe Gly Leu Ser Gly Ser Asp Ala Asn Glu Thr Asn Ile 
        115                 120                 125             


Lys Leu Ile Trp Tyr Tyr Asn Asn Val Leu Gly Arg Pro Glu Lys Lys 
    130                 135                 140                 


Lys Ile Ile Ser Arg Trp Arg Gly Tyr His Gly Ser Gly Val Met Thr 
145                 150                 155                 160 


Gly Ser Leu Thr Gly Leu Asp Leu Phe His Asn Ala Phe Asp Leu Pro 
                165                 170                 175     


Arg Ala Pro Val Leu His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Thr 
            180                 185                 190         


Asp Arg Ser Met Ser Glu Glu Gln Phe Ser Gln His Cys Ala Asp Lys 
        195                 200                 205             


Leu Glu Glu Met Ile Leu Ala Glu Gly Pro Glu Thr Ile Ala Ala Phe 
    210                 215                 220                 


Ile Gly Glu Pro Ile Leu Gly Ala Gly Gly Phe Val Pro Pro Pro Ala 
225                 230                 235                 240 


Gly Tyr Trp Glu Lys Ile Gln Ala Val Leu Lys Lys Tyr Asp Val Leu 
                245                 250                 255     


Leu Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met 
            260                 265                 270         


Phe Gly Ser Asp His Tyr Gly Ile Lys Pro Asp Leu Ile Thr Ile Ala 
        275                 280                 285             


Lys Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Val Ile Val Ala 
    290                 295                 300                 


Asp Arg Val Trp Gln Val Leu Val Gln Gly Ser Asp Lys Leu Gly Ser 
305                 310                 315                 320 


Leu Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Cys Val Ala Ala 
                325                 330                 335     


Gly Val Ala Asn Leu Glu Leu Ile Asp Glu Met Asp Leu Val Thr Asn 
            340                 345                 350         


Ala Gly Glu Thr Gly Ala Tyr Phe Arg Ala Glu Leu Ala Lys Ala Val 
        355                 360                 365             


Gly Gly His Lys Asn Val Gly Glu Val Arg Gly Asp Gly Met Leu Ala 
    370                 375                 380                 


Ala Val Glu Phe Val Ala Asp Lys Asp Asp Arg Val Phe Phe Asp Ala 
385                 390                 395                 400 


Ser Gln Lys Ile Gly Pro Gln Val Ala Thr Ala Leu Ala Ala Ser Gly 
                405                 410                 415     


Val Ile Gly Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Leu Cys Leu Thr Arg Glu Gln Ala Asp Ile Val Val Ser Lys Thr 
        435                 440                 445             


Ala Asp Ala Val Lys Ser Val Phe Ala Asn Leu 
    450                 455                 


<210>  29
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  29

Met Leu Asn Gln Ser Asn Glu Leu Asn Ala Trp Asp Arg Asp His Phe 
1               5                   10                  15      


Phe His Pro Ser Thr His Met Gly Thr His Ala Arg Gly Glu Ser Pro 
            20                  25                  30          


Thr Arg Ile Met Ala Gly Gly Glu Gly Val Thr Val Trp Asp Asn Asn 
        35                  40                  45              


Gly Arg Lys Ser Ile Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Val 
    50                  55                  60                  


Gly Tyr Gly Arg Gln Lys Ile Ala Asp Ala Ile Ala Thr Gln Ala Lys 
65                  70                  75                  80  


Asn Leu Ala Tyr Tyr His Ala Tyr Val Gly His Gly Thr Glu Ala Ser 
                85                  90                  95      


Ile Thr Leu Ala Lys Met Ile Ile Asp Arg Ala Pro Lys Gly Met Ser 
            100                 105                 110         


Arg Val Tyr Phe Gly Leu Ser Gly Ser Asp Ala Asn Glu Thr Asn Ile 
        115                 120                 125             


Lys Leu Ile Trp Tyr Tyr Asn Asn Val Leu Gly Arg Pro Glu Lys Lys 
    130                 135                 140                 


Lys Ile Ile Ser Arg Trp Arg Gly Tyr His Gly Ser Gly Val Met Thr 
145                 150                 155                 160 


Gly Ser Leu Thr Gly Leu Asp Leu Phe His Asn Ala Phe Asp Leu Pro 
                165                 170                 175     


Arg Ala Pro Val Leu His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Thr 
            180                 185                 190         


Asp Arg Ser Met Ser Glu Glu Gln Phe Ser Gln His Cys Ala Asp Lys 
        195                 200                 205             


Leu Glu Glu Met Ile Leu Ala Glu Gly Pro Glu Thr Ile Ala Ala Phe 
    210                 215                 220                 


Ile Gly Glu Pro Ile Leu Gly Ala Gly Gly Met Val Pro Pro Pro Ala 
225                 230                 235                 240 


Gly Tyr Trp Glu Lys Ile Gln Ala Val Leu Lys Lys Tyr Asp Val Leu 
                245                 250                 255     


Leu Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met 
            260                 265                 270         


Phe Gly Ser Asp His Tyr Gly Ile Lys Pro Asp Leu Ile Thr Ile Ala 
        275                 280                 285             


Lys Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Val Ile Val Ala 
    290                 295                 300                 


Asp Arg Val Trp Gln Val Leu Val Gln Gly Ser Asp Lys Leu Gly Ser 
305                 310                 315                 320 


Leu Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Cys Val Ala Ala 
                325                 330                 335     


Gly Val Ala Asn Leu Glu Leu Ile Asp Glu Met Asp Leu Val Thr Asn 
            340                 345                 350         


Ala Gly Glu Thr Gly Ala Tyr Phe Arg Ala Glu Leu Ala Lys Ala Val 
        355                 360                 365             


Gly Gly His Lys Asn Val Gly Glu Val Arg Gly Asp Gly Met Leu Ala 
    370                 375                 380                 


Ala Val Glu Phe Val Ala Asp Lys Asp Asp Arg Val Phe Phe Asp Ala 
385                 390                 395                 400 


Ser Gln Lys Ile Gly Pro Gln Val Ala Thr Ala Leu Ala Ala Ser Gly 
                405                 410                 415     


Val Ile Gly Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Leu Cys Leu Thr Arg Glu Gln Ala Asp Ile Val Val Ser Lys Thr 
        435                 440                 445             


Ala Asp Ala Val Lys Ser Val Phe Ala Asn Leu 
    450                 455                 


<210>  30
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant transaminase

<400>  30

Met Leu Lys Asn Asp Gln Leu Asp Gln Trp Asp Arg Asp Asn Phe Phe 
1               5                   10                  15      


His Pro Ser Thr His Leu Ala Gln His Ala Arg Gly Glu Ser Ala Asn 
            20                  25                  30          


Arg Val Ile Lys Thr Ala Ser Gly Val Phe Ile Glu Asp Arg Asp Gly 
        35                  40                  45              


Thr Lys Leu Leu Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Gln Glu Ile Ala Glu Ala Ile Ala Asp Gln Ala Arg Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Ser Phe Val Gly His Gly Thr Glu Ala Ser Ile 
                85                  90                  95      


Thr Leu Ala Lys Met Ile Leu Asp Arg Ala Pro Lys Asn Met Ser Lys 
            100                 105                 110         


Val Tyr Phe Gly Leu Gly Gly Ser Asp Ala Asn Glu Thr Asn Val Lys 
        115                 120                 125             


Leu Ile Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Phe His Gly Ser Gly Leu Val Thr Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Glu Leu Phe His Lys Lys Phe Asp Leu Pro Val 
                165                 170                 175     


Glu Gln Val Ile His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Glu Asp 
            180                 185                 190         


Leu Asn Gln Thr Glu Glu Gln Phe Val Ala His Cys Val Ala Glu Leu 
        195                 200                 205             


Glu Ala Leu Ile Glu Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Ile Leu Gly Ala Gly Gly Ile Val Pro Pro Pro Ala Gly 
225                 230                 235                 240 


Tyr Trp Glu Ala Ile Gln Thr Val Leu Asn Lys His Asp Ile Leu Leu 
                245                 250                 255     


Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met Phe 
            260                 265                 270         


Gly Ser Asp His Tyr Gly Leu Glu Pro Asp Ile Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Ile Val Ser Asp 
    290                 295                 300                 


Lys Val Trp Lys Val Leu Glu Gln Gly Thr Asp Glu Asn Gly Pro Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Leu Asp Glu Leu Asn Leu Val Ser Asn Ala 
            340                 345                 350         


Gly Glu Val Gly Ala Tyr Leu Asn Ala Thr Met Ala Glu Ala Leu Ser 
        355                 360                 365             


Gln His Ala Asn Val Gly Asp Val Arg Gly Glu Gly Leu Leu Cys Ala 
    370                 375                 380                 


Val Glu Phe Val Lys Asp Arg Asp Ser Arg Thr Phe Phe Asp Ala Ala 
385                 390                 395                 400 


Asp Lys Ile Gly Pro Gln Ile Ser Ala Lys Leu Leu Glu Gln Asp Lys 
                405                 410                 415     


Ile Ile Ala Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Phe Cys Leu Thr Arg Ala Glu Ala Asp Gln Val Val Glu Gly Thr 
        435                 440                 445             


Leu Arg Ala Val Lys Ala Val Leu Gly 
    450                 455         


<210>  31
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  31

Met Leu Asn Gln Ser Asn Glu Leu Asn Ala Trp Asp Arg Asp His Phe 
1               5                   10                  15      


Phe His Pro Ser Thr His Met Gly Thr His Ala Arg Gly Glu Ser Pro 
            20                  25                  30          


Thr Arg Ile Met Ala Gly Gly Glu Gly Val Thr Val Trp Asp Asn Asn 
        35                  40                  45              


Gly Arg Lys Ser Ile Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Val 
    50                  55                  60                  


Gly Tyr Gly Arg Gln Lys Ile Ala Asp Ala Ile Ala Thr Gln Ala Lys 
65                  70                  75                  80  


Asn Leu Ala Tyr Tyr His Ala Leu Val Gly His Gly Thr Glu Ala Ser 
                85                  90                  95      


Ile Thr Leu Ala Lys Met Ile Ile Asp Arg Ala Pro Lys Gly Met Ser 
            100                 105                 110         


Arg Val Tyr Phe Gly Leu Ser Gly Ser Asp Ala Asn Glu Thr Asn Ile 
        115                 120                 125             


Lys Leu Ile Trp Tyr Tyr Asn Asn Val Leu Gly Arg Pro Glu Lys Lys 
    130                 135                 140                 


Lys Ile Ile Ser Arg Trp Arg Gly Tyr His Gly Ser Gly Val Met Thr 
145                 150                 155                 160 


Gly Ser Leu Thr Gly Leu Asp Leu Phe His Asn Ala Phe Asp Leu Pro 
                165                 170                 175     


Arg Ala Pro Val Leu His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Thr 
            180                 185                 190         


Asp Arg Ser Met Ser Glu Glu Gln Phe Ser Gln His Cys Ala Asp Lys 
        195                 200                 205             


Leu Glu Glu Met Ile Leu Ala Glu Gly Pro Glu Thr Ile Ala Ala Phe 
    210                 215                 220                 


Ile Gly Glu Pro Ile Leu Gly Ala Gly Gly Ile Val Pro Pro Pro Ala 
225                 230                 235                 240 


Gly Tyr Trp Glu Lys Ile Gln Ala Val Leu Lys Lys Tyr Asp Val Leu 
                245                 250                 255     


Leu Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met 
            260                 265                 270         


Phe Gly Ser Asp His Tyr Gly Ile Lys Pro Asp Leu Ile Thr Ile Ala 
        275                 280                 285             


Lys Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Val Ile Val Ala 
    290                 295                 300                 


Asp Arg Val Trp Gln Val Leu Val Gln Gly Ser Asp Lys Leu Gly Ser 
305                 310                 315                 320 


Leu Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Cys Val Ala Ala 
                325                 330                 335     


Gly Val Ala Asn Leu Glu Leu Ile Asp Glu Met Asp Leu Val Thr Asn 
            340                 345                 350         


Ala Gly Glu Thr Gly Ala Tyr Phe Arg Ala Glu Leu Ala Lys Ala Val 
        355                 360                 365             


Gly Gly His Lys Asn Val Gly Glu Val Arg Gly Asp Gly Met Leu Ala 
    370                 375                 380                 


Ala Val Glu Phe Val Ala Asp Lys Asp Asp Arg Val Phe Phe Asp Ala 
385                 390                 395                 400 


Ser Gln Lys Ile Gly Pro Gln Val Ala Thr Ala Leu Ala Ala Ser Gly 
                405                 410                 415     


Val Ile Gly Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Leu Cys Leu Thr Arg Glu Gln Ala Asp Ile Val Val Ser Lys Thr 
        435                 440                 445             


Ala Asp Ala Val Lys Ser Val Phe Ala Asn Leu 
    450                 455                 


<210>  32
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant transaminase

<400>  32

Met Leu Lys Asn Asp Pro Leu Glu Gln Trp Asp Arg Asp His Phe Leu 
1               5                   10                  15      


His Pro Ser Thr His Leu Ala Glu Phe Ala Arg Gly Asn Val Ala His 
            20                  25                  30          


Arg Ile Val Ser Gly Gly Glu Gly Ser His Ile Val Asp Arg Asn Gly 
        35                  40                  45              


Thr Arg Leu Leu Asp Gly Phe Ala Gly Leu Trp Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Arg Glu Ile Ala Asp Ala Ile Ala Lys Gln Ala Arg Glu 
65                  70                  75                  80  


Leu Ser Tyr Tyr His Ser Phe Val Gly His Gly Thr Glu Ala Ser Val 
                85                  90                  95      


Thr Leu Ala His Met Ile Leu Glu Arg Ala Pro Ala Asn Met Ser Lys 
            100                 105                 110         


Val Phe Phe Gly Leu Gly Gly Ser Asp Ala Asn Glu Thr Asn Ile Lys 
        115                 120                 125             


Leu Ile Trp Tyr Met Asn Asn Ile Leu Gly Arg Pro Gly Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Phe His Gly Ser Gly Leu Met Ser Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Pro Leu Phe His Lys Ala Phe Asp Leu Pro Leu 
                165                 170                 175     


Ala Pro Ile Leu His Thr Glu Ala Pro Tyr Tyr Tyr Arg Arg Pro Asn 
            180                 185                 190         


Ala Asp Met Ser Glu Glu Ala Phe Ser Ala Trp Cys Ala Ser Glu Leu 
        195                 200                 205             


Glu Ala Met Ile Gln Arg Glu Gly Pro Asp Thr Ile Ala Ala Phe Trp 
    210                 215                 220                 


Ala Glu Pro Val Leu Gly Ala Gly Gly Ile Val Pro Pro Pro Glu Gly 
225                 230                 235                 240 


Tyr Trp Ala Ala Ile Gln Glu Val Leu Asp Arg His Asp Ile Leu Leu 
                245                 250                 255     


Val Ala Asp Glu Val Ile Thr Gly Phe Gly Arg Leu Gly Thr Met Phe 
            260                 265                 270         


Gly Ser Asp His Tyr Gly Met Lys Pro Asp Val Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Val Leu Ser Glu 
    290                 295                 300                 


Lys Val Trp Lys Val Leu Glu Gln Gly Thr Asp Glu Met Gly Ala Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Ile Asp Glu Leu Gly Leu Ile Asp Asn Ala 
            340                 345                 350         


Ala Glu Val Gly Ala His Leu Arg Ala Gly Met Arg Asp Ala Leu Gly 
        355                 360                 365             


Glu His Pro Asn Val Gly Asp Ile Arg Gly Glu Gly Met Leu Cys Ala 
    370                 375                 380                 


Val Glu Leu Val Ser Asp Arg Glu Ser Lys Glu Gly Phe Asp Pro Ser 
385                 390                 395                 400 


Arg Lys Val Thr Val Asn Ala Val Ala His Leu Met Glu Asn Gly Val 
                405                 410                 415     


Ile Gly Arg Ala Met Pro His Ser Glu Thr Ile Gly Phe Ala Pro Pro 
            420                 425                 430         


Phe Cys Leu Thr Arg Asp Glu Ala Asp Glu Ile Val Ala Lys Thr Ala 
        435                 440                 445             


Ala Ala Val Lys Ala Val Leu Gly 
    450                 455     


<210>  33
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant transaminase

<400>  33

Met Leu Thr Asn Asp Gln Leu Ser Gln Trp Asp Gln Asp His Phe Phe 
1               5                   10                  15      


His Pro Ser Thr Ala Leu Gly Ala His Ala Arg Gly Glu Ala Pro Gly 
            20                  25                  30          


Met Val Val Gln Thr Ala Glu Gly Cys His Ile Thr Asp Arg Asn Gly 
        35                  40                  45              


Asn Arg Met Leu Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Ile Gly 
    50                  55                  60                  


Tyr Gly Arg Gln Glu Val Ala Glu Ala Ile Ala Ala Gln Ala Arg Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Ser Phe Met Gly Asn Gly Thr Glu Ala Ser Ile 
                85                  90                  95      


Thr Leu Ala Lys Met Val Thr Glu Arg Ala Pro Glu Gly Met Asn Arg 
            100                 105                 110         


Val Tyr Phe Gly Gln Gly Gly Ser Asp Ala Asn Glu Thr Asn Ile Lys 
        115                 120                 125             


Leu Val Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Val Ser Arg Trp Arg Gly Phe His Gly Ser Gly Leu Met Ser Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Ser Leu Phe His Arg Lys Phe Asp Leu Pro Leu 
                165                 170                 175     


Asp Lys Val Leu His Thr Thr Ala Pro Tyr Tyr Phe Gln Arg Glu Asn 
            180                 185                 190         


Val Ala Gln Ser Glu Gln Glu Phe Thr Ala Gln Cys Val Ala Asp Leu 
        195                 200                 205             


Glu Glu Leu Ile Ala Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Ala Glu Pro Val Ile Gly Ala Gly Gly Ile Val Pro Pro Pro Glu Gly 
225                 230                 235                 240 


Tyr Trp Asn Ala Ile Gln Pro Val Leu Lys Arg His Asp Ile Leu Leu 
                245                 250                 255     


Ile Ala Asp Glu Val Ile Thr Gly Phe Gly Arg Leu Gly Ala Met Phe 
            260                 265                 270         


Gly Ser Pro Leu Tyr Gly Ile Glu Pro Asp Ile Met Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Ile Val His Asp 
    290                 295                 300                 


Arg Val Trp Asp Val Leu Ala Arg Gly Thr Asp Glu Asn Gly Pro Leu 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Thr Leu Leu Asp Thr Leu Gly Leu Val Asp Asn Ala 
            340                 345                 350         


Ala Asp Val Gly Pro Tyr Leu Thr Ala Gln Met Arg Ala Ala Met Gln 
        355                 360                 365             


Asp His Ala His Val Gly Asp Ile Arg Gly Val Gly Met Leu Thr Ala 
    370                 375                 380                 


Val Glu Leu Val Ala Asp Arg Asp Lys Gly Ser Gly Val Gly Ala Gly 
385                 390                 395                 400 


Phe Asp Pro Ala Ala Lys Ile Val Pro Gln Ile Ser Ala Ala Met Ala 
                405                 410                 415     


Lys His Gly Val Ile Ala Arg Ala Met Pro Gln Ala Asp Ile Val Gly 
            420                 425                 430         


Phe Ser Pro Pro Leu Cys Leu Thr Arg Ala Glu Ala Asp Thr Ile Val 
        435                 440                 445             


Ser Val Thr Ala Glu Ala Val Ala Glu Val Leu Gly 
    450                 455                 460 


<210>  34
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant transaminase

<400>  34

Met Leu Asp His Pro Ala Pro Ala Ser Asn Ala Phe Asp Ser Trp Asp 
1               5                   10                  15      


Arg Asp His Phe Phe His Pro Ser Thr His Met Gly Gln His Ala Arg 
            20                  25                  30          


Gly Glu Thr Pro Asn Arg Ile Ile Thr Gly Ala Glu Gly Val Tyr Ile 
        35                  40                  45              


Val Asp Arg Glu Gly Arg Arg Ser Leu Asp Ala Phe Gly Gly Leu Trp 
    50                  55                  60                  


Cys Val Asn Val Gly Tyr Gly Arg Ser Lys Ile Thr Asp Ala Ile Ala 
65                  70                  75                  80  


Glu Gln Ala Ser Lys Leu Ala Tyr Tyr His Ala Phe Ala Gly His Gly 
                85                  90                  95      


Ser Glu Pro Ser Ile Arg Leu Ala Arg Met Val Ile Glu Arg Ala Pro 
            100                 105                 110         


Ala Gly Met Ser Arg Val Phe Phe Gly Leu Ser Gly Ser Asp Ala Asn 
        115                 120                 125             


Glu Thr Asn Ile Lys Leu Val Trp Tyr Ile Asn Asn Val Leu Gly Arg 
    130                 135                 140                 


Pro Gln Lys Lys Lys Ile Ile Ser Arg Trp Arg Gly Phe His Gly Ser 
145                 150                 155                 160 


Gly Val Met Thr Gly Ser Leu Thr Gly Leu Ala Gly Phe His Lys Leu 
                165                 170                 175     


Phe Asp Leu Pro Arg Ala Pro Ile Leu His Thr Glu Ala Pro Tyr Tyr 
            180                 185                 190         


Phe Arg Arg Glu Asp Arg Ser Met Ser Glu Glu Gln Phe Ser Gln His 
        195                 200                 205             


Cys Ala Asp Arg Leu Glu Glu Met Ile Leu Thr Glu Gly Ala Asp Thr 
    210                 215                 220                 


Ile Ala Ala Phe Ile Gly Glu Pro Val Leu Gly Ala Gly Gly Ile Val 
225                 230                 235                 240 


Pro Pro Pro Ala Gly Tyr Trp Pro Lys Ile Gln Ala Val Leu Lys Lys 
                245                 250                 255     


Tyr Asp Ile Met Leu Ile Ala Asp Glu Val Val Thr Gly Phe Gly Arg 
            260                 265                 270         


Leu Gly Ser Met Phe Gly Ser Asp His Tyr Gly Ile Glu Pro Asp Leu 
        275                 280                 285             


Ile Thr Ile Ala Lys Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly 
    290                 295                 300                 


Val Ile Val Ser Glu Lys Val Trp Arg Val Leu Glu Gln Gly Ser Asp 
305                 310                 315                 320 


Glu Phe Gly Pro Ile Gly His Gly Trp Thr Tyr Ser Ser His Pro Leu 
                325                 330                 335     


Cys Thr Ala Ala Gly Val Ala Asn Leu Glu Leu Val Asp Glu Leu Asp 
            340                 345                 350         


Leu Val Thr Asn Ala Arg Glu Thr Gly Ala Tyr Phe Asn Ala Ala Leu 
        355                 360                 365             


Lys Asp Ala Leu Ser Gly His Arg His Val Gly Glu Val Arg Gly Glu 
    370                 375                 380                 


Gly Leu Leu Ala Ala Val Glu Leu Val Arg Asp Arg Asp Asp Arg Thr 
385                 390                 395                 400 


Phe Phe Glu Ala Ser Glu Lys Val Gly Pro Arg Val Ala Ala Ala Met 
                405                 410                 415     


Leu Glu Arg Gly Val Ile Ala Arg Ala Met Pro Gln Gly Asp Ile Leu 
            420                 425                 430         


Gly Phe Ala Pro Pro Leu Cys Leu Thr Arg Glu Glu Ala Asp Ile Val 
        435                 440                 445             


Val Asp Ala Thr Arg Gly Ala Val Glu Ala Val Cys Ala Thr Leu Gly 
    450                 455                 460                 


<210>  35
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant transaminase

<400>  35

Met Leu Arg Asn Asp Gln Leu Ala Glu Trp Asp Arg Glu Asn Phe Phe 
1               5                   10                  15      


His Ala Ser Thr His Leu Ala Ala His Ala Arg Gly Asp Thr Pro Thr 
            20                  25                  30          


Arg Ile Ile Thr Gly Gly Glu Gly Val Tyr Ile Gln Asp Arg Asp Gly 
        35                  40                  45              


Ala Lys Ile Leu Asp Gly Phe Ala Gly Leu Trp Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Arg Glu Ile Thr Asp Ala Ile Ala Ala Gln Val Ser Glu 
65                  70                  75                  80  


Leu Ser Tyr Tyr His Ala Phe Ala Gly His Gly Thr Glu Ala Ser Val 
                85                  90                  95      


Thr Leu Ala Lys Met Val Leu Asp Arg Ala Pro Asp Asn Met Ser Lys 
            100                 105                 110         


Val Tyr Phe Gly Leu Gly Gly Ser Asp Ala Asn Glu Thr Asn Ile Lys 
        115                 120                 125             


Leu Ile Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Phe His Gly Ser Gly Leu Met Thr Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Gly Leu Phe His Ala Lys Phe Asp Leu Pro Met 
                165                 170                 175     


Asp Gly Val Leu His Thr Glu Ala Pro His Tyr Leu His Arg Ala Asp 
            180                 185                 190         


Arg Asn Gln Thr Glu Glu Gln Phe Ser Ala Tyr Cys Ala Ala Lys Leu 
        195                 200                 205             


Glu Glu Met Ile Leu Ala Glu Gly Pro Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Ile Leu Gly Ala Gly Gly Ile Val Pro Pro Pro Lys Gly 
225                 230                 235                 240 


Tyr Trp Ala Ala Ile Gln Ala Val Leu Arg Lys Tyr Asp Ile Leu Leu 
                245                 250                 255     


Val Val Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met Phe 
            260                 265                 270         


Gly Ser Glu His Tyr Gly Leu Lys Ala Asp Leu Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Ile Val Ser Lys 
    290                 295                 300                 


Lys Met Trp Ala Val Leu Glu Lys Gly Thr Asp Glu Asn Gly Ala Phe 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Ile Asp Asp Leu Gly Leu Ile Ala Asn Ala 
            340                 345                 350         


Ser Glu Thr Gly Ala Tyr Leu Lys Ser Ala Leu Gln Ala Ala Leu Gly 
        355                 360                 365             


Asp His Pro Asn Val Ala Glu Ile Arg Gly Glu Gly Met Leu Ala Ala 
    370                 375                 380                 


Val Glu Phe Cys Ala Asp Arg Asp Asp Leu Lys Gln Phe Asp Thr Ser 
385                 390                 395                 400 


Ala Thr Ile Gly Pro Arg Leu Ala Ala Glu Leu Leu Thr Arg Gly Val 
                405                 410                 415     


Ile Gly Arg Ala Met Pro Gln Ser Asp Thr Ile Gly Phe Ala Pro Pro 
            420                 425                 430         


Leu Cys Ile Thr Arg Ala Glu Val Asp Gln Ile Val Ala Ala Met Lys 
        435                 440                 445             


Gly Ala Val Asp Ala Val Leu Pro Ala 
    450                 455         


<210>  36
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant transaminase

<400>  36

Met Leu Thr Asn Asp Gln Leu Asp Arg Phe Asp Arg Glu Asn Phe Phe 
1               5                   10                  15      


His Pro Ser Thr His Leu Ala Gln His Ala Arg Gly Glu Ser Pro Ser 
            20                  25                  30          


Arg Ile Val Lys Thr Ala Lys Gly Val Phe Ile Glu Asp Arg Asp Gly 
        35                  40                  45              


Asn Lys Leu Leu Asp Gly Phe Gly Gly Leu Trp Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Gln Glu Ser Ile Ile Glu Ala Ile Ala Glu Gln Ala Lys Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Ala Phe Ala Gly His Gly Thr Glu Ala Ser Ile 
                85                  90                  95      


Asn Leu Ala Lys Met Val Ile Asp Arg Ala Pro Asp His Met Ser Lys 
            100                 105                 110         


Val Tyr Phe Gly Leu Ser Gly Ser Asp Ala Asn Glu Thr Asn Ile Lys 
        115                 120                 125             


Leu Ile Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Phe His Gly Ser Gly Leu Met Thr Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Ala Gly Phe Gln Arg Lys Phe Asp Leu Pro Leu 
                165                 170                 175     


Glu Arg Val Phe His Thr Thr Ala Pro Tyr Tyr Tyr Arg Arg Lys Asp 
            180                 185                 190         


Leu Ala Met Ser Glu Ala Asp Phe Val Ala His Cys Val Ala Glu Leu 
        195                 200                 205             


Glu Met Arg Ile Glu Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Val Leu Gly Ala Gly Gly Ile Val Pro Pro Pro Glu Gly 
225                 230                 235                 240 


Tyr Trp Lys Ala Ile Ser Ala Val Leu Glu Lys His Asp Ile Leu Leu 
                245                 250                 255     


Ile Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Ser Met Phe 
            260                 265                 270         


Gly Ser Asp His Tyr Gly Leu Lys Pro Asp Leu Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Thr Ile Val Ser Asp 
    290                 295                 300                 


Lys Val Trp Lys Val Leu Glu Gln Gly Thr Asp Glu Asn Gly Pro Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Ile Asp Glu Leu Gly Leu Val Lys Asn Ala 
            340                 345                 350         


Ala Glu Thr Gly Ala Tyr Leu Arg Ala Ala Met Lys Asp Ala Leu Ser 
        355                 360                 365             


Asp His Pro His Val Gly Asp Ile Arg Gly Glu Gly Met Leu Met Ala 
    370                 375                 380                 


Val Glu Phe Val Lys Asp Arg Glu Ser Arg Thr Phe Tyr Asp Pro Ser 
385                 390                 395                 400 


Glu Lys Val Gly Pro Asn Leu Ala Ala Ala Leu Ile Ser Glu Gly Val 
                405                 410                 415     


Ile Ala Arg Ala Met Pro Glu Gly Asp Ile Leu Gly Tyr Ala Pro Pro 
            420                 425                 430         


Leu Cys Leu Thr Arg Glu Glu Ala Asp Gln Ile Val Ala Ala Thr Lys 
        435                 440                 445             


Lys Ala Val Ile Ala Val Leu Gly 
    450                 455     


<210>  37
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant transaminase

<400>  37

Met Leu Lys Asn Asp Gln Leu Asp Gln Trp Asp Arg Glu Asn Phe Phe 
1               5                   10                  15      


His Pro Ser Thr His Leu Ala Gln His Ala Arg Gly Asp Ser Ala Asn 
            20                  25                  30          


Arg Val Ile Lys Thr Ala Ser Gly Val Phe Ile Glu Asp Arg Asp Gly 
        35                  40                  45              


Asn Lys Leu Leu Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Gln Glu Ile Ala Asp Ala Ile Ala Asp Gln Ala Arg Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Ser Phe Val Gly His Gly Thr Glu Ala Ser Ile 
                85                  90                  95      


Thr Leu Ala Lys Met Ile Leu Asp Arg Ala Pro Ala Asn Met Ser Lys 
            100                 105                 110         


Val Tyr Phe Gly Leu Gly Gly Ser Asp Ala Asn Glu Thr Asn Val Lys 
        115                 120                 125             


Leu Ile Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Phe His Gly Ser Gly Leu Val Thr Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Glu Leu Phe His Lys Lys Phe Asp Leu Pro Val 
                165                 170                 175     


Asn Gln Val Ile His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Ala Asp 
            180                 185                 190         


Pro Asp Gln Ser Glu Ala Gln Phe Val Ala His Cys Ala Ala Glu Leu 
        195                 200                 205             


Glu Ala Leu Ile Glu Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Val Leu Gly Ala Gly Gly Ile Val Pro Pro Pro Ala Gly 
225                 230                 235                 240 


Tyr Trp Glu Ala Ile Gln Ala Val Leu Arg Lys His Asp Ile Leu Leu 
                245                 250                 255     


Ile Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met Phe 
            260                 265                 270         


Gly Ser Asp His Tyr Gly Ile Glu Ala Asp Ile Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Ile Ile Ser Asp 
    290                 295                 300                 


Lys Val Trp Lys Val Leu Glu Gln Gly Thr Asp Glu Asn Gly Pro Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Ile Asp Arg Leu Asn Leu Val Gln Asn Ala 
            340                 345                 350         


Gly Glu Thr Gly Ala Tyr Leu Asn Ala Thr Met Thr Glu Ala Leu Ala 
        355                 360                 365             


Gly His Pro Asn Val Gly Glu Val Arg Gly Ala Gly Met Leu Cys Ala 
    370                 375                 380                 


Val Glu Phe Val Lys Asp Lys Asp Ser Arg Leu Phe Phe Asp Ala Ala 
385                 390                 395                 400 


Asp Lys Ile Gly Pro Gln Ile Ser Ala Lys Leu Leu Glu Gln Asp Lys 
                405                 410                 415     


Val Ile Ala Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Phe Cys Leu Ser Arg Ala Glu Ala Asp Gln Val Val Asp Ala Thr 
        435                 440                 445             


Leu Arg Ala Val Arg Thr Val Leu Gly 
    450                 455         


<210>  38
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant transaminase

<400>  38

Met Leu Thr Asn Asp Gln Leu Ser Gln Trp Asp Arg Glu Asn Phe Phe 
1               5                   10                  15      


His Pro Ser Thr His Leu Ala Gln His Ala Arg Gly Glu Thr Ala Thr 
            20                  25                  30          


Arg Val Ile Thr Thr Gly Gln Gly Cys His Ile Glu Asp Arg Asp Gly 
        35                  40                  45              


Thr Lys Leu Leu Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Thr Glu Ile Ala Asp Ala Ile Ala Ala Gln Ala Lys Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Ala Phe Val Gly His Gly Thr Glu Ala Ser Ile 
                85                  90                  95      


Thr Leu Ser Lys Met Ile Leu Asp Arg Ala Pro Ala His Met Ser Lys 
            100                 105                 110         


Val Tyr Phe Gly Leu Ser Gly Ser Asp Ala Asn Glu Thr Asn Ile Lys 
        115                 120                 125             


Leu Ile Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Phe His Gly Ser Gly Leu Met Thr Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Glu Leu Phe His Lys Lys Phe Asp Leu Pro Leu 
                165                 170                 175     


Ala Gln Val Ile His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Pro Asp 
            180                 185                 190         


Leu Ala Met Ser Glu Glu Ala Phe Ser Ala Tyr Cys Ala Ala Glu Leu 
        195                 200                 205             


Glu Gln Leu Ile Glu Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Val Leu Gly Ala Gly Gly Ile Val Pro Pro Pro Lys Gly 
225                 230                 235                 240 


Tyr Trp Glu Ala Ile Gln Pro Ile Leu Glu Lys His Asp Ile Leu Leu 
                245                 250                 255     


Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met Phe 
            260                 265                 270         


Gly Ser Asp His Tyr Gly Leu Lys Pro Asp Leu Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Ile Val Gly Asp 
    290                 295                 300                 


Lys Met Trp Lys Val Leu Glu Gln Gly Thr Asp Glu Asn Gly Pro Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Ile Asp Asp Met Asn Leu Val Ala Asn Ala 
            340                 345                 350         


Gly Glu Thr Gly Ala His Phe Arg Lys Ala Met Thr Asp Ala Leu Gly 
        355                 360                 365             


Asp His Ala Lys Val Gly Asp Ile Arg Gly Glu Gly Met Leu Cys Ala 
    370                 375                 380                 


Val Glu Leu Val Asp Asp Lys Asp Asn Arg Thr Phe Phe Asp Pro Ser 
385                 390                 395                 400 


Gln Lys Val Gly Ala Gln Ile Ala Ser Ala Leu Leu Ser Lys Gly Val 
                405                 410                 415     


Ile Ala Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro Pro 
            420                 425                 430         


Leu Cys Leu Thr Pro Ala Glu Ala Glu Glu Val Ala Thr Lys Thr Gly 
        435                 440                 445             


Glu Ala Val Arg Asp Val Leu Gly 
    450                 455     


<210>  39
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  39

Met Leu Lys Asn Asp Gln Leu Asp Gln Trp Asp Arg Asp Asn Phe Phe 
1               5                   10                  15      


His Pro Ser Thr His Leu Ala Gln His Ala Arg Gly Glu Ser Ala Asn 
            20                  25                  30          


Arg Val Ile Lys Thr Ala Ser Gly Val Phe Ile Glu Asp Arg Asp Gly 
        35                  40                  45              


Thr Lys Leu Leu Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Gln Glu Ile Ala Glu Ala Ile Ala Asp Gln Ala Arg Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Ser Leu Val Gly His Gly Thr Glu Ala Ser Ile 
                85                  90                  95      


Thr Leu Ala Lys Met Ile Leu Asp Arg Ala Pro Lys Asn Met Ser Lys 
            100                 105                 110         


Val Tyr Phe Gly Leu Gly Gly Ser Asp Ala Asn Glu Thr Asn Val Lys 
        115                 120                 125             


Leu Ile Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Phe His Gly Ser Gly Leu Val Thr Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Glu Leu Phe His Lys Lys Phe Asp Leu Pro Val 
                165                 170                 175     


Glu Gln Val Ile His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Glu Asp 
            180                 185                 190         


Leu Asn Gln Thr Glu Glu Gln Phe Val Ala His Cys Val Ala Glu Leu 
        195                 200                 205             


Glu Ala Leu Ile Glu Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Ile Leu Gly Ala Gly Gly Ile Val Pro Pro Pro Ala Gly 
225                 230                 235                 240 


Tyr Trp Glu Ala Ile Gln Thr Val Leu Asn Lys His Asp Ile Leu Leu 
                245                 250                 255     


Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met Phe 
            260                 265                 270         


Gly Ser Asp His Tyr Gly Leu Glu Pro Asp Ile Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Ile Val Ser Asp 
    290                 295                 300                 


Lys Val Trp Lys Val Leu Glu Gln Gly Thr Asp Glu Asn Gly Pro Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Leu Asp Glu Leu Asn Leu Val Ser Asn Ala 
            340                 345                 350         


Gly Glu Val Gly Ala Tyr Leu Asn Ala Thr Met Ala Glu Ala Leu Ser 
        355                 360                 365             


Gln His Ala Asn Val Gly Asp Val Arg Gly Glu Gly Leu Leu Cys Ala 
    370                 375                 380                 


Val Glu Phe Val Lys Asp Arg Asp Ser Arg Thr Phe Phe Asp Ala Ala 
385                 390                 395                 400 


Asp Lys Ile Gly Pro Gln Ile Ser Ala Lys Leu Leu Glu Gln Asp Lys 
                405                 410                 415     


Ile Ile Ala Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Phe Cys Leu Thr Arg Ala Glu Ala Asp Gln Val Val Glu Gly Thr 
        435                 440                 445             


Leu Arg Ala Val Lys Ala Val Leu Gly 
    450                 455         


<210>  40
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  40

Met Leu Lys Asn Asp Gln Leu Asp Gln Trp Asp Arg Asp Asn Phe Phe 
1               5                   10                  15      


His Pro Ser Thr His Leu Ala Gln His Ala Arg Gly Glu Ser Ala Asn 
            20                  25                  30          


Arg Val Ile Lys Thr Ala Ser Gly Val Phe Ile Glu Asp Arg Asp Gly 
        35                  40                  45              


Thr Lys Leu Leu Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Gln Glu Ile Ala Glu Ala Ile Ala Asp Gln Ala Arg Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Ser Phe Val Gly His Gly Thr Glu Ala Ser Ile 
                85                  90                  95      


Thr Leu Ala Lys Met Ile Leu Asp Arg Ala Pro Lys Asn Met Ser Lys 
            100                 105                 110         


Val Tyr Phe Gly Leu Gly Gly Ser Asp Ala Asn Glu Thr Asn Val Lys 
        115                 120                 125             


Leu Ile Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Tyr His Gly Ser Gly Leu Val Thr Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Glu Leu Phe His Lys Lys Phe Asp Leu Pro Val 
                165                 170                 175     


Glu Gln Val Ile His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Glu Asp 
            180                 185                 190         


Leu Asn Gln Thr Glu Glu Gln Phe Val Ala His Cys Val Ala Glu Leu 
        195                 200                 205             


Glu Ala Leu Ile Glu Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Ile Leu Gly Ala Gly Gly Ile Val Pro Pro Pro Ala Gly 
225                 230                 235                 240 


Tyr Trp Glu Ala Ile Gln Thr Val Leu Asn Lys His Asp Ile Leu Leu 
                245                 250                 255     


Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met Phe 
            260                 265                 270         


Gly Ser Asp His Tyr Gly Leu Glu Pro Asp Ile Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Ile Val Ser Asp 
    290                 295                 300                 


Lys Val Trp Lys Val Leu Glu Gln Gly Thr Asp Glu Asn Gly Pro Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Leu Asp Glu Leu Asn Leu Val Ser Asn Ala 
            340                 345                 350         


Gly Glu Val Gly Ala Tyr Leu Asn Ala Thr Met Ala Glu Ala Leu Ser 
        355                 360                 365             


Gln His Ala Asn Val Gly Asp Val Arg Gly Glu Gly Leu Leu Cys Ala 
    370                 375                 380                 


Val Glu Phe Val Lys Asp Arg Asp Ser Arg Thr Phe Phe Asp Ala Ala 
385                 390                 395                 400 


Asp Lys Ile Gly Pro Gln Ile Ser Ala Lys Leu Leu Glu Gln Asp Lys 
                405                 410                 415     


Ile Ile Ala Arg Ala Met His Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Phe Cys Leu Thr Arg Ala Glu Ala Asp Gln Val Val Glu Gly Thr 
        435                 440                 445             


Leu Arg Ala Val Lys Ala Val Leu Gly 
    450                 455         


<210>  41
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  41

Met Leu Asn Gln Ser Asn Glu Leu Asn Ala Trp Asp Arg Asp His Phe 
1               5                   10                  15      


Phe His Pro Ser Thr His Met Gly Thr His Ala Arg Gly Glu Ser Pro 
            20                  25                  30          


Thr Arg Ile Met Ala Gly Gly Glu Gly Val Thr Val Trp Asp Asn Asn 
        35                  40                  45              


Gly Arg Lys Ser Ile Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Val 
    50                  55                  60                  


Gly Tyr Gly Arg Gln Lys Ile Ala Asp Ala Ile Ala Thr Gln Ala Lys 
65                  70                  75                  80  


Asn Leu Ala Tyr Tyr His Ala Phe Val Gly His Gly Thr Glu Ala Ser 
                85                  90                  95      


Ile Thr Leu Ala Lys Met Ile Ile Asp Arg Ala Pro Lys Gly Met Ser 
            100                 105                 110         


Arg Val Tyr Phe Gly Leu Ser Gly Ser Asp Ala Asn Glu Thr Asn Ile 
        115                 120                 125             


Lys Leu Ile Trp Tyr Tyr Asn Asn Val Leu Gly Arg Pro Glu Lys Lys 
    130                 135                 140                 


Lys Ile Ile Ser Arg Trp Arg Gly Phe His Gly Ser Gly Val Met Thr 
145                 150                 155                 160 


Gly Ser Leu Thr Gly Leu Asp Leu Phe His Asn Ala Phe Asp Leu Pro 
                165                 170                 175     


Arg Ala Pro Val Leu His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Thr 
            180                 185                 190         


Asp Arg Ser Met Ser Glu Glu Gln Phe Ser Gln His Cys Ala Asp Lys 
        195                 200                 205             


Leu Glu Glu Met Ile Leu Ala Glu Gly Pro Glu Thr Ile Ala Ala Phe 
    210                 215                 220                 


Ile Gly Glu Pro Ile Leu Gly Ala Gly Gly Ile Val Pro Pro Pro Ala 
225                 230                 235                 240 


Gly Tyr Trp Glu Lys Ile Gln Ala Val Leu Lys Lys Tyr Asp Val Leu 
                245                 250                 255     


Leu Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met 
            260                 265                 270         


Phe Gly Ser Asp His Tyr Gly Ile Lys Pro Asp Leu Ile Thr Ile Ala 
        275                 280                 285             


Lys Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Val Ile Val Ala 
    290                 295                 300                 


Asp Arg Val Trp Gln Val Leu Val Gln Gly Ser Asp Lys Leu Gly Ser 
305                 310                 315                 320 


Leu Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Cys Val Ala Ala 
                325                 330                 335     


Gly Val Ala Asn Leu Glu Leu Ile Asp Glu Met Asp Leu Val Thr Asn 
            340                 345                 350         


Ala Gly Glu Thr Gly Ala Tyr Phe Arg Ala Glu Leu Ala Lys Ala Val 
        355                 360                 365             


Gly Gly His Lys Asn Val Gly Glu Val Arg Gly Asp Gly Met Leu Ala 
    370                 375                 380                 


Ala Val Glu Phe Val Ala Asp Lys Asp Asp Arg Val Phe Phe Asp Ala 
385                 390                 395                 400 


Ser Gln Lys Ile Gly Pro Gln Val Ala Thr Ala Leu Ala Ala Ser Gly 
                405                 410                 415     


Val Ile Gly Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Leu Cys Leu Thr Arg Glu Gln Ala Asp Ile Val Val Ser Lys Thr 
        435                 440                 445             


Ala Asp Ala Val Lys Ser Val Phe Ala Asn Leu 
    450                 455                 


<210>  42
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  42

Met Leu Asn Gln Ser Asn Glu Leu Asn Ala Trp Asp Arg Asp His Phe 
1               5                   10                  15      


Phe His Pro Ser Thr His Met Gly Thr His Ala Arg Gly Glu Ser Pro 
            20                  25                  30          


Thr Arg Ile Met Ala Gly Gly Glu Gly Val Thr Val Trp Asp Asn Asn 
        35                  40                  45              


Gly Arg Lys Ser Ile Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Val 
    50                  55                  60                  


Gly Tyr Gly Arg Gln Lys Ile Ala Asp Ala Ile Ala Thr Gln Ala Lys 
65                  70                  75                  80  


Asn Leu Ala Tyr Tyr His Ala Phe Val Gly His Gly Thr Glu Ala Ser 
                85                  90                  95      


Ile Thr Leu Ala Lys Met Ile Ile Asp Arg Ala Pro Lys Gly Met Ser 
            100                 105                 110         


Arg Val Tyr Phe Gly Leu Ser Gly Ser Asp Ala Asn Glu Thr Asn Ile 
        115                 120                 125             


Lys Leu Ile Trp Tyr Tyr Asn Asn Val Leu Gly Arg Pro Glu Lys Lys 
    130                 135                 140                 


Lys Ile Ile Ser Arg Trp Arg Gly Tyr His Gly Ser Gly Val Met Thr 
145                 150                 155                 160 


Gly Ser Leu Thr Gly Leu Asp Leu Phe His Asn Ala Phe Asp Leu Pro 
                165                 170                 175     


Arg Ala Pro Val Leu His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Thr 
            180                 185                 190         


Asp Arg Ser Met Ser Glu Glu Gln Phe Ser Gln His Cys Ala Asp Lys 
        195                 200                 205             


Leu Glu Glu Met Ile Leu Ala Glu Gly Pro Glu Thr Ile Ala Ala Phe 
    210                 215                 220                 


Ile Gly Glu Pro Ile Leu Gly Ala Gly Gly Ile Val Pro Pro Pro Ala 
225                 230                 235                 240 


Gly Tyr Trp Glu Lys Ile Gln Ala Val Leu Lys Lys Tyr Asp Val Leu 
                245                 250                 255     


Leu Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met 
            260                 265                 270         


Phe Gly Ser Asp His Tyr Gly Ile Lys Pro Asp Leu Ile Thr Ile Ala 
        275                 280                 285             


Lys Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Val Ile Val Ala 
    290                 295                 300                 


Asp Arg Val Trp Gln Val Leu Val Gln Gly Ser Asp Lys Leu Gly Ser 
305                 310                 315                 320 


Leu Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Cys Val Ala Ala 
                325                 330                 335     


Gly Val Ala Asn Leu Glu Leu Ile Asp Glu Met Asp Leu Val Thr Asn 
            340                 345                 350         


Ala Gly Glu Thr Gly Ala Tyr Phe Arg Ala Glu Leu Ala Lys Ala Val 
        355                 360                 365             


Gly Gly His Lys Asn Val Gly Glu Val Arg Gly Asp Gly Met Leu Ala 
    370                 375                 380                 


Ala Val Glu Phe Val Ala Asp Lys Asp Asp Arg Val Phe Phe Asp Ala 
385                 390                 395                 400 


Ser Gln Lys Ile Gly Pro Gln Val Ala Thr Ala Leu Ala Ala Ser Gly 
                405                 410                 415     


Val Ile Gly Arg Ala Met His Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Leu Cys Leu Thr Arg Glu Gln Ala Asp Ile Val Val Ser Lys Thr 
        435                 440                 445             


Ala Asp Ala Val Lys Ser Val Phe Ala Asn Leu 
    450                 455                 


<210>  43
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant transaminase

<400>  43

Met Leu Lys Asn Asp Gln Leu Asp Gln Trp Asp Arg Asp Asn Phe Phe 
1               5                   10                  15      


His Pro Ser Thr His Leu Ala Gln His Ala Arg Gly Glu Ser Ala Asn 
            20                  25                  30          


Arg Val Ile Lys Thr Ala Ser Gly Val Phe Ile Glu Asp Arg Asp Gly 
        35                  40                  45              


Thr Lys Leu Leu Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Gln Glu Ile Ala Glu Ala Ile Ala Asp Gln Ala Arg Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Ser Phe Val Gly His Gly Thr Glu Ala Ser Ile 
                85                  90                  95      


Thr Leu Ala Lys Met Ile Leu Asp Arg Ala Pro Lys Asn Met Ser Lys 
            100                 105                 110         


Val Tyr Phe Gly Leu Gly Gly Ser Asp Ala Asn Glu Thr Asn Val Lys 
        115                 120                 125             


Leu Ile Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Phe His Gly Ser Gly Leu Val Thr Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Glu Leu Phe His Lys Lys Phe Asp Leu Pro Val 
                165                 170                 175     


Glu Gln Val Ile His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Glu Asp 
            180                 185                 190         


Leu Asn Gln Thr Glu Glu Gln Phe Val Ala His Cys Val Ala Glu Leu 
        195                 200                 205             


Glu Ala Leu Ile Glu Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Ile Leu Gly Ala Gly Gly Ile Val Pro Pro Pro Ala Gly 
225                 230                 235                 240 


Tyr Trp Glu Ala Ile Gln Thr Val Leu Asn Lys His Asp Ile Leu Leu 
                245                 250                 255     


Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met Phe 
            260                 265                 270         


Gly Ser Asp His Tyr Gly Leu Glu Pro Asp Ile Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Ile Val Ser Asp 
    290                 295                 300                 


Lys Val Trp Lys Val Leu Glu Gln Gly Thr Asp Glu Asn Gly Pro Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Leu Asp Glu Leu Asn Leu Val Ser Asn Ala 
            340                 345                 350         


Gly Glu Val Gly Ala Tyr Leu Asn Ala Thr Met Ala Glu Ala Leu Ser 
        355                 360                 365             


Gln His Ala Asn Val Gly Asp Val Arg Gly Glu Gly Leu Leu Cys Ala 
    370                 375                 380                 


Val Glu Phe Val Lys Asp Arg Asp Ser Arg Thr Phe Phe Asp Ala Ala 
385                 390                 395                 400 


Asp Lys Ile Gly Pro Gln Ile Ser Ala Lys Leu Leu Glu Gln Asp Lys 
                405                 410                 415     


Ile Ile Ala Arg Ala Met His Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Phe Cys Leu Thr Arg Ala Glu Ala Asp Gln Val Val Glu Gly Thr 
        435                 440                 445             


Leu Arg Ala Val Lys Ala Val Leu Gly 
    450                 455         


<210>  44
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  44

Met Leu Asn Gln Ser Asn Glu Leu Asn Ala Trp Asp Arg Asp His Phe 
1               5                   10                  15      


Phe His Pro Ser Thr His Met Gly Thr His Ala Arg Gly Glu Ser Pro 
            20                  25                  30          


Thr Arg Ile Met Ala Gly Gly Glu Gly Val Thr Val Trp Asp Asn Asn 
        35                  40                  45              


Gly Arg Lys Ser Ile Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Val 
    50                  55                  60                  


Gly Tyr Gly Arg Gln Lys Ile Ala Asp Ala Ile Ala Thr Gln Ala Lys 
65                  70                  75                  80  


Asn Leu Ala Tyr Tyr His Ala Phe Val Gly His Gly Thr Glu Ala Ser 
                85                  90                  95      


Ile Thr Leu Ala Lys Met Ile Ile Asp Arg Ala Pro Lys Gly Met Ser 
            100                 105                 110         


Arg Val Tyr Phe Gly Leu Ser Gly Ser Asp Ala Asn Glu Thr Asn Ile 
        115                 120                 125             


Lys Leu Ile Trp Tyr Tyr Asn Asn Val Leu Gly Arg Pro Glu Lys Lys 
    130                 135                 140                 


Lys Ile Ile Ser Arg Trp Arg Gly Phe His Gly Ser Gly Val Met Thr 
145                 150                 155                 160 


Gly Ser Leu Thr Gly Leu Asp Leu Phe His Asn Ala Phe Asp Leu Pro 
                165                 170                 175     


Arg Ala Pro Val Leu His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Thr 
            180                 185                 190         


Asp Arg Ser Met Ser Glu Glu Gln Phe Ser Gln His Cys Ala Asp Lys 
        195                 200                 205             


Leu Glu Glu Met Ile Leu Ala Glu Gly Pro Glu Thr Ile Ala Ala Phe 
    210                 215                 220                 


Ile Gly Glu Pro Ile Leu Gly Ala Gly Gly Ile Val Pro Pro Pro Ala 
225                 230                 235                 240 


Gly Tyr Trp Glu Lys Ile Gln Ala Val Leu Lys Lys Tyr Asp Val Leu 
                245                 250                 255     


Leu Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met 
            260                 265                 270         


Phe Gly Ser Asp His Tyr Gly Ile Lys Pro Asp Leu Ile Thr Ile Ala 
        275                 280                 285             


Lys Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Val Ile Val Ala 
    290                 295                 300                 


Asp Arg Val Trp Gln Val Leu Val Gln Gly Ser Asp Lys Leu Gly Ser 
305                 310                 315                 320 


Leu Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Cys Val Ala Ala 
                325                 330                 335     


Gly Val Ala Asn Leu Glu Leu Ile Asp Glu Met Asp Leu Val Thr Asn 
            340                 345                 350         


Ala Gly Glu Thr Gly Ala Tyr Phe Arg Ala Glu Leu Ala Lys Ala Val 
        355                 360                 365             


Gly Gly His Lys Asn Val Gly Glu Val Arg Gly Asp Gly Met Leu Ala 
    370                 375                 380                 


Ala Val Glu Phe Val Ala Asp Lys Asp Asp Arg Val Phe Phe Asp Ala 
385                 390                 395                 400 


Ser Gln Lys Ile Gly Pro Gln Val Ala Thr Ala Leu Ala Ala Ser Gly 
                405                 410                 415     


Val Ile Gly Arg Ala Met His Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Leu Cys Leu Thr Arg Glu Gln Ala Asp Ile Val Val Ser Lys Thr 
        435                 440                 445             


Ala Asp Ala Val Lys Ser Val Phe Ala Asn Leu 
    450                 455                 


<210>  45
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant transaminase

<400>  45

Met Leu Lys Asn Asp Pro Leu Glu Gln Trp Asp Arg Asp His Phe Leu 
1               5                   10                  15      


His Pro Ser Thr His Leu Ala Glu Phe Ala Arg Gly Asn Val Ala His 
            20                  25                  30          


Arg Ile Val Ser Gly Gly Glu Gly Ser His Ile Val Asp Arg Asn Gly 
        35                  40                  45              


Thr Arg Leu Leu Asp Gly Phe Ala Gly Leu Trp Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Arg Glu Ile Ala Asp Ala Ile Ala Lys Gln Ala Arg Glu 
65                  70                  75                  80  


Leu Ser Tyr Tyr His Ser Phe Val Gly His Gly Thr Glu Ala Ser Val 
                85                  90                  95      


Thr Leu Ala His Met Ile Leu Glu Arg Ala Pro Ala Asn Met Ser Lys 
            100                 105                 110         


Val Phe Phe Gly Leu Gly Gly Ser Asp Ala Asn Glu Thr Asn Ile Lys 
        115                 120                 125             


Leu Ile Trp Tyr Met Asn Asn Ile Leu Gly Arg Pro Gly Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Phe His Gly Ser Gly Leu Met Ser Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Pro Leu Phe His Lys Ala Phe Asp Leu Pro Leu 
                165                 170                 175     


Ala Pro Ile Leu His Thr Glu Ala Pro Tyr Tyr Tyr Arg Arg Pro Asn 
            180                 185                 190         


Ala Asp Met Ser Glu Glu Ala Phe Ser Ala Trp Cys Ala Ser Glu Leu 
        195                 200                 205             


Glu Ala Met Ile Gln Arg Glu Gly Pro Asp Thr Ile Ala Ala Phe Trp 
    210                 215                 220                 


Ala Glu Pro Val Leu Gly Ala Gly Gly Ile Val Pro Pro Pro Glu Gly 
225                 230                 235                 240 


Tyr Trp Ala Ala Ile Gln Glu Val Leu Asp Arg His Asp Ile Leu Leu 
                245                 250                 255     


Val Ala Asp Glu Val Ile Thr Gly Phe Gly Arg Leu Gly Thr Met Phe 
            260                 265                 270         


Gly Ser Asp His Tyr Gly Met Lys Pro Asp Val Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Val Leu Ser Glu 
    290                 295                 300                 


Lys Val Trp Lys Val Leu Glu Gln Gly Thr Asp Glu Met Gly Ala Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Ile Asp Glu Leu Gly Leu Ile Asp Asn Ala 
            340                 345                 350         


Ala Glu Val Gly Ala His Leu Arg Ala Gly Met Arg Asp Ala Leu Gly 
        355                 360                 365             


Glu His Pro Asn Val Gly Asp Ile Arg Gly Glu Gly Met Leu Cys Ala 
    370                 375                 380                 


Val Glu Leu Val Ser Asp Arg Glu Ser Lys Glu Gly Phe Asp Pro Ser 
385                 390                 395                 400 


Arg Lys Val Thr Val Asn Ala Val Ala His Leu Met Glu Asn Gly Val 
                405                 410                 415     


Ile Gly Arg Ala Met Pro His Ser Glu Thr Ile Gly Phe Ala Pro Pro 
            420                 425                 430         


Phe Cys Leu Thr Arg Asp Glu Ala Asp Glu Ile Val Ala Lys Thr Ala 
        435                 440                 445             


Ala Ala Val Lys Ala Val Leu Gly 
    450                 455     


<210>  46
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant transaminase

<400>  46

Met Leu Thr Asn Asp Gln Leu Ser Gln Trp Asp Gln Asp His Phe Phe 
1               5                   10                  15      


His Pro Ser Thr Ala Leu Gly Ala His Ala Arg Gly Glu Ala Pro Gly 
            20                  25                  30          


Met Val Val Gln Thr Ala Glu Gly Cys His Ile Thr Asp Arg Asn Gly 
        35                  40                  45              


Asn Arg Met Leu Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Ile Gly 
    50                  55                  60                  


Tyr Gly Arg Gln Glu Val Ala Glu Ala Ile Ala Ala Gln Ala Arg Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Ser Phe Met Gly Asn Gly Thr Glu Ala Ser Ile 
                85                  90                  95      


Thr Leu Ala Lys Met Val Thr Glu Arg Ala Pro Glu Gly Met Asn Arg 
            100                 105                 110         


Val Tyr Phe Gly Gln Gly Gly Ser Asp Ala Asn Glu Thr Asn Ile Lys 
        115                 120                 125             


Leu Val Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Val Ser Arg Trp Arg Gly Phe His Gly Ser Gly Leu Met Ser Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Ser Leu Phe His Arg Lys Phe Asp Leu Pro Leu 
                165                 170                 175     


Asp Lys Val Leu His Thr Thr Ala Pro Tyr Tyr Phe Gln Arg Glu Asn 
            180                 185                 190         


Val Ala Gln Ser Glu Gln Glu Phe Thr Ala Gln Cys Val Ala Asp Leu 
        195                 200                 205             


Glu Glu Leu Ile Ala Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Ala Glu Pro Val Ile Gly Ala Gly Gly Ile Val Pro Pro Pro Glu Gly 
225                 230                 235                 240 


Tyr Trp Asn Ala Ile Gln Pro Val Leu Lys Arg His Asp Ile Leu Leu 
                245                 250                 255     


Ile Ala Asp Glu Val Ile Thr Gly Phe Gly Arg Leu Gly Ala Met Phe 
            260                 265                 270         


Gly Ser Pro Leu Tyr Gly Ile Glu Pro Asp Ile Met Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Ile Val His Asp 
    290                 295                 300                 


Arg Val Trp Asp Val Leu Ala Arg Gly Thr Asp Glu Asn Gly Pro Leu 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Thr Leu Leu Asp Thr Leu Gly Leu Val Asp Asn Ala 
            340                 345                 350         


Ala Asp Val Gly Pro Tyr Leu Thr Ala Gln Met Arg Ala Ala Met Gln 
        355                 360                 365             


Asp His Ala His Val Gly Asp Ile Arg Gly Val Gly Met Leu Thr Ala 
    370                 375                 380                 


Val Glu Leu Val Ala Asp Arg Asp Lys Gly Ser Gly Val Gly Ala Gly 
385                 390                 395                 400 


Phe Asp Pro Ala Ala Lys Ile Val Pro Gln Ile Ser Ala Ala Met Ala 
                405                 410                 415     


Lys His Gly Val Ile Ala Arg Ala Met His Gln Ala Asp Ile Val Gly 
            420                 425                 430         


Phe Ser Pro Pro Leu Cys Leu Thr Arg Ala Glu Ala Asp Thr Ile Val 
        435                 440                 445             


Ser Val Thr Ala Glu Ala Val Ala Glu Val Leu Gly 
    450                 455                 460 


<210>  47
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant transaminase

<400>  47

Met Leu Asp His Pro Ala Pro Ala Ser Asn Ala Phe Asp Ser Trp Asp 
1               5                   10                  15      


Arg Asp His Phe Phe His Pro Ser Thr His Met Gly Gln His Ala Arg 
            20                  25                  30          


Gly Glu Thr Pro Asn Arg Ile Ile Thr Gly Ala Glu Gly Val Tyr Ile 
        35                  40                  45              


Val Asp Arg Glu Gly Arg Arg Ser Leu Asp Ala Phe Gly Gly Leu Trp 
    50                  55                  60                  


Cys Val Asn Val Gly Tyr Gly Arg Ser Lys Ile Thr Asp Ala Ile Ala 
65                  70                  75                  80  


Glu Gln Ala Ser Lys Leu Ala Tyr Tyr His Ala Phe Ala Gly His Gly 
                85                  90                  95      


Ser Glu Pro Ser Ile Arg Leu Ala Arg Met Val Ile Glu Arg Ala Pro 
            100                 105                 110         


Ala Gly Met Ser Arg Val Phe Phe Gly Leu Ser Gly Ser Asp Ala Asn 
        115                 120                 125             


Glu Thr Asn Ile Lys Leu Val Trp Tyr Ile Asn Asn Val Leu Gly Arg 
    130                 135                 140                 


Pro Gln Lys Lys Lys Ile Ile Ser Arg Trp Arg Gly Phe His Gly Ser 
145                 150                 155                 160 


Gly Val Met Thr Gly Ser Leu Thr Gly Leu Ala Gly Phe His Lys Leu 
                165                 170                 175     


Phe Asp Leu Pro Arg Ala Pro Ile Leu His Thr Glu Ala Pro Tyr Tyr 
            180                 185                 190         


Phe Arg Arg Glu Asp Arg Ser Met Ser Glu Glu Gln Phe Ser Gln His 
        195                 200                 205             


Cys Ala Asp Arg Leu Glu Glu Met Ile Leu Thr Glu Gly Ala Asp Thr 
    210                 215                 220                 


Ile Ala Ala Phe Ile Gly Glu Pro Val Leu Gly Ala Gly Gly Ile Val 
225                 230                 235                 240 


Pro Pro Pro Ala Gly Tyr Trp Pro Lys Ile Gln Ala Val Leu Lys Lys 
                245                 250                 255     


Tyr Asp Ile Met Leu Ile Ala Asp Glu Val Val Thr Gly Phe Gly Arg 
            260                 265                 270         


Leu Gly Ser Met Phe Gly Ser Asp His Tyr Gly Ile Glu Pro Asp Leu 
        275                 280                 285             


Ile Thr Ile Ala Lys Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly 
    290                 295                 300                 


Val Ile Val Ser Glu Lys Val Trp Arg Val Leu Glu Gln Gly Ser Asp 
305                 310                 315                 320 


Glu Phe Gly Pro Ile Gly His Gly Trp Thr Tyr Ser Ser His Pro Leu 
                325                 330                 335     


Cys Thr Ala Ala Gly Val Ala Asn Leu Glu Leu Val Asp Glu Leu Asp 
            340                 345                 350         


Leu Val Thr Asn Ala Arg Glu Thr Gly Ala Tyr Phe Asn Ala Ala Leu 
        355                 360                 365             


Lys Asp Ala Leu Ser Gly His Arg His Val Gly Glu Val Arg Gly Glu 
    370                 375                 380                 


Gly Leu Leu Ala Ala Val Glu Leu Val Arg Asp Arg Asp Asp Arg Thr 
385                 390                 395                 400 


Phe Phe Glu Ala Ser Glu Lys Val Gly Pro Arg Val Ala Ala Ala Met 
                405                 410                 415     


Leu Glu Arg Gly Val Ile Ala Arg Ala Met His Gln Gly Asp Ile Leu 
            420                 425                 430         


Gly Phe Ala Pro Pro Leu Cys Leu Thr Arg Glu Glu Ala Asp Ile Val 
        435                 440                 445             


Val Asp Ala Thr Arg Gly Ala Val Glu Ala Val Cys Ala Thr Leu Gly 
    450                 455                 460                 


<210>  48
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant transaminase

<400>  48

Met Leu Arg Asn Asp Gln Leu Ala Glu Trp Asp Arg Glu Asn Phe Phe 
1               5                   10                  15      


His Ala Ser Thr His Leu Ala Ala His Ala Arg Gly Asp Thr Pro Thr 
            20                  25                  30          


Arg Ile Ile Thr Gly Gly Glu Gly Val Tyr Ile Gln Asp Arg Asp Gly 
        35                  40                  45              


Ala Lys Ile Leu Asp Gly Phe Ala Gly Leu Trp Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Arg Glu Ile Thr Asp Ala Ile Ala Ala Gln Val Ser Glu 
65                  70                  75                  80  


Leu Ser Tyr Tyr His Ala Phe Ala Gly His Gly Thr Glu Ala Ser Val 
                85                  90                  95      


Thr Leu Ala Lys Met Val Leu Asp Arg Ala Pro Asp Asn Met Ser Lys 
            100                 105                 110         


Val Tyr Phe Gly Leu Gly Gly Ser Asp Ala Asn Glu Thr Asn Ile Lys 
        115                 120                 125             


Leu Ile Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Phe His Gly Ser Gly Leu Met Thr Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Gly Leu Phe His Ala Lys Phe Asp Leu Pro Met 
                165                 170                 175     


Asp Gly Val Leu His Thr Glu Ala Pro His Tyr Leu His Arg Ala Asp 
            180                 185                 190         


Arg Asn Gln Thr Glu Glu Gln Phe Ser Ala Tyr Cys Ala Ala Lys Leu 
        195                 200                 205             


Glu Glu Met Ile Leu Ala Glu Gly Pro Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Ile Leu Gly Ala Gly Gly Ile Val Pro Pro Pro Lys Gly 
225                 230                 235                 240 


Tyr Trp Ala Ala Ile Gln Ala Val Leu Arg Lys Tyr Asp Ile Leu Leu 
                245                 250                 255     


Val Val Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met Phe 
            260                 265                 270         


Gly Ser Glu His Tyr Gly Leu Lys Ala Asp Leu Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Ile Val Ser Lys 
    290                 295                 300                 


Lys Met Trp Ala Val Leu Glu Lys Gly Thr Asp Glu Asn Gly Ala Phe 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Ile Asp Asp Leu Gly Leu Ile Ala Asn Ala 
            340                 345                 350         


Ser Glu Thr Gly Ala Tyr Leu Lys Ser Ala Leu Gln Ala Ala Leu Gly 
        355                 360                 365             


Asp His Pro Asn Val Ala Glu Ile Arg Gly Glu Gly Met Leu Ala Ala 
    370                 375                 380                 


Val Glu Phe Cys Ala Asp Arg Asp Asp Leu Lys Gln Phe Asp Thr Ser 
385                 390                 395                 400 


Ala Thr Ile Gly Pro Arg Leu Ala Ala Glu Leu Leu Thr Arg Gly Val 
                405                 410                 415     


Ile Gly Arg Ala Met His Gln Ser Asp Thr Ile Gly Phe Ala Pro Pro 
            420                 425                 430         


Leu Cys Ile Thr Arg Ala Glu Val Asp Gln Ile Val Ala Ala Met Lys 
        435                 440                 445             


Gly Ala Val Asp Ala Val Leu Pro Ala 
    450                 455         


<210>  49
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant transaminase

<400>  49

Met Leu Thr Asn Asp Gln Leu Asp Arg Phe Asp Arg Glu Asn Phe Phe 
1               5                   10                  15      


His Pro Ser Thr His Leu Ala Gln His Ala Arg Gly Glu Ser Pro Ser 
            20                  25                  30          


Arg Ile Val Lys Thr Ala Lys Gly Val Phe Ile Glu Asp Arg Asp Gly 
        35                  40                  45              


Asn Lys Leu Leu Asp Gly Phe Gly Gly Leu Trp Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Gln Glu Ser Ile Ile Glu Ala Ile Ala Glu Gln Ala Lys Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Ala Phe Ala Gly His Gly Thr Glu Ala Ser Ile 
                85                  90                  95      


Asn Leu Ala Lys Met Val Ile Asp Arg Ala Pro Asp His Met Ser Lys 
            100                 105                 110         


Val Tyr Phe Gly Leu Ser Gly Ser Asp Ala Asn Glu Thr Asn Ile Lys 
        115                 120                 125             


Leu Ile Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Phe His Gly Ser Gly Leu Met Thr Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Ala Gly Phe Gln Arg Lys Phe Asp Leu Pro Leu 
                165                 170                 175     


Glu Arg Val Phe His Thr Thr Ala Pro Tyr Tyr Tyr Arg Arg Lys Asp 
            180                 185                 190         


Leu Ala Met Ser Glu Ala Asp Phe Val Ala His Cys Val Ala Glu Leu 
        195                 200                 205             


Glu Met Arg Ile Glu Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Val Leu Gly Ala Gly Gly Ile Val Pro Pro Pro Glu Gly 
225                 230                 235                 240 


Tyr Trp Lys Ala Ile Ser Ala Val Leu Glu Lys His Asp Ile Leu Leu 
                245                 250                 255     


Ile Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Ser Met Phe 
            260                 265                 270         


Gly Ser Asp His Tyr Gly Leu Lys Pro Asp Leu Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Thr Ile Val Ser Asp 
    290                 295                 300                 


Lys Val Trp Lys Val Leu Glu Gln Gly Thr Asp Glu Asn Gly Pro Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Ile Asp Glu Leu Gly Leu Val Lys Asn Ala 
            340                 345                 350         


Ala Glu Thr Gly Ala Tyr Leu Arg Ala Ala Met Lys Asp Ala Leu Ser 
        355                 360                 365             


Asp His Pro His Val Gly Asp Ile Arg Gly Glu Gly Met Leu Met Ala 
    370                 375                 380                 


Val Glu Phe Val Lys Asp Arg Glu Ser Arg Thr Phe Tyr Asp Pro Ser 
385                 390                 395                 400 


Glu Lys Val Gly Pro Asn Leu Ala Ala Ala Leu Ile Ser Glu Gly Val 
                405                 410                 415     


Ile Ala Arg Ala Met His Glu Gly Asp Ile Leu Gly Tyr Ala Pro Pro 
            420                 425                 430         


Leu Cys Leu Thr Arg Glu Glu Ala Asp Gln Ile Val Ala Ala Thr Lys 
        435                 440                 445             


Lys Ala Val Ile Ala Val Leu Gly 
    450                 455     


<210>  50
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant transaminase

<400>  50

Met Leu Lys Asn Asp Gln Leu Asp Gln Trp Asp Arg Glu Asn Phe Phe 
1               5                   10                  15      


His Pro Ser Thr His Leu Ala Gln His Ala Arg Gly Asp Ser Ala Asn 
            20                  25                  30          


Arg Val Ile Lys Thr Ala Ser Gly Val Phe Ile Glu Asp Arg Asp Gly 
        35                  40                  45              


Asn Lys Leu Leu Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Gln Glu Ile Ala Asp Ala Ile Ala Asp Gln Ala Arg Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Ser Phe Val Gly His Gly Thr Glu Ala Ser Ile 
                85                  90                  95      


Thr Leu Ala Lys Met Ile Leu Asp Arg Ala Pro Ala Asn Met Ser Lys 
            100                 105                 110         


Val Tyr Phe Gly Leu Gly Gly Ser Asp Ala Asn Glu Thr Asn Val Lys 
        115                 120                 125             


Leu Ile Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Phe His Gly Ser Gly Leu Val Thr Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Glu Leu Phe His Lys Lys Phe Asp Leu Pro Val 
                165                 170                 175     


Asn Gln Val Ile His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Ala Asp 
            180                 185                 190         


Pro Asp Gln Ser Glu Ala Gln Phe Val Ala His Cys Ala Ala Glu Leu 
        195                 200                 205             


Glu Ala Leu Ile Glu Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Val Leu Gly Ala Gly Gly Ile Val Pro Pro Pro Ala Gly 
225                 230                 235                 240 


Tyr Trp Glu Ala Ile Gln Ala Val Leu Arg Lys His Asp Ile Leu Leu 
                245                 250                 255     


Ile Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met Phe 
            260                 265                 270         


Gly Ser Asp His Tyr Gly Ile Glu Ala Asp Ile Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Ile Ile Ser Asp 
    290                 295                 300                 


Lys Val Trp Lys Val Leu Glu Gln Gly Thr Asp Glu Asn Gly Pro Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Ile Asp Arg Leu Asn Leu Val Gln Asn Ala 
            340                 345                 350         


Gly Glu Thr Gly Ala Tyr Leu Asn Ala Thr Met Thr Glu Ala Leu Ala 
        355                 360                 365             


Gly His Pro Asn Val Gly Glu Val Arg Gly Ala Gly Met Leu Cys Ala 
    370                 375                 380                 


Val Glu Phe Val Lys Asp Lys Asp Ser Arg Leu Phe Phe Asp Ala Ala 
385                 390                 395                 400 


Asp Lys Ile Gly Pro Gln Ile Ser Ala Lys Leu Leu Glu Gln Asp Lys 
                405                 410                 415     


Val Ile Ala Arg Ala Met His Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Phe Cys Leu Ser Arg Ala Glu Ala Asp Gln Val Val Asp Ala Thr 
        435                 440                 445             


Leu Arg Ala Val Arg Thr Val Leu Gly 
    450                 455         


<210>  51
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant transaminase

<400>  51

Met Leu Thr Asn Asp Gln Leu Ser Gln Trp Asp Arg Glu Asn Phe Phe 
1               5                   10                  15      


His Pro Ser Thr His Leu Ala Gln His Ala Arg Gly Glu Thr Ala Thr 
            20                  25                  30          


Arg Val Ile Thr Thr Gly Gln Gly Cys His Ile Glu Asp Arg Asp Gly 
        35                  40                  45              


Thr Lys Leu Leu Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Thr Glu Ile Ala Asp Ala Ile Ala Ala Gln Ala Lys Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Ala Phe Val Gly His Gly Thr Glu Ala Ser Ile 
                85                  90                  95      


Thr Leu Ser Lys Met Ile Leu Asp Arg Ala Pro Ala His Met Ser Lys 
            100                 105                 110         


Val Tyr Phe Gly Leu Ser Gly Ser Asp Ala Asn Glu Thr Asn Ile Lys 
        115                 120                 125             


Leu Ile Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Phe His Gly Ser Gly Leu Met Thr Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Glu Leu Phe His Lys Lys Phe Asp Leu Pro Leu 
                165                 170                 175     


Ala Gln Val Ile His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Pro Asp 
            180                 185                 190         


Leu Ala Met Ser Glu Glu Ala Phe Ser Ala Tyr Cys Ala Ala Glu Leu 
        195                 200                 205             


Glu Gln Leu Ile Glu Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Val Leu Gly Ala Gly Gly Ile Val Pro Pro Pro Lys Gly 
225                 230                 235                 240 


Tyr Trp Glu Ala Ile Gln Pro Ile Leu Glu Lys His Asp Ile Leu Leu 
                245                 250                 255     


Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met Phe 
            260                 265                 270         


Gly Ser Asp His Tyr Gly Leu Lys Pro Asp Leu Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Ile Val Gly Asp 
    290                 295                 300                 


Lys Met Trp Lys Val Leu Glu Gln Gly Thr Asp Glu Asn Gly Pro Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Ile Asp Asp Met Asn Leu Val Ala Asn Ala 
            340                 345                 350         


Gly Glu Thr Gly Ala His Phe Arg Lys Ala Met Thr Asp Ala Leu Gly 
        355                 360                 365             


Asp His Ala Lys Val Gly Asp Ile Arg Gly Glu Gly Met Leu Cys Ala 
    370                 375                 380                 


Val Glu Leu Val Asp Asp Lys Asp Asn Arg Thr Phe Phe Asp Pro Ser 
385                 390                 395                 400 


Gln Lys Val Gly Ala Gln Ile Ala Ser Ala Leu Leu Ser Lys Gly Val 
                405                 410                 415     


Ile Ala Arg Ala Met His Gln Gly Asp Ile Leu Gly Phe Ala Pro Pro 
            420                 425                 430         


Leu Cys Leu Thr Pro Ala Glu Ala Glu Glu Val Ala Thr Lys Thr Gly 
        435                 440                 445             


Glu Ala Val Arg Asp Val Leu Gly 
    450                 455     


<210>  52
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  52

Met Leu Lys Asn Asp Gln Leu Asp Gln Trp Asp Arg Asp Asn Phe Phe 
1               5                   10                  15      


His Pro Ser Thr His Leu Ala Gln His Ala Arg Gly Glu Ser Ala Asn 
            20                  25                  30          


Arg Val Ile Lys Thr Ala Ser Gly Val Phe Ile Glu Asp Arg Asp Gly 
        35                  40                  45              


Thr Lys Leu Leu Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Gln Glu Ile Ala Glu Ala Ile Ala Asp Gln Ala Arg Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Ser Phe Val Gly His Gly Thr Glu Ala Ser Ile 
                85                  90                  95      


Thr Leu Ala Lys Met Ile Leu Asp Arg Ala Pro Lys Asn Met Ser Lys 
            100                 105                 110         


Val Tyr Phe Gly Leu Gly Gly Ser Asp Ala Asn Glu Thr Asn Val Lys 
        115                 120                 125             


Leu Ile Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Phe His Gly Ser Gly Leu Val Thr Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Glu Leu Phe His Lys Lys Phe Asp Leu Pro Val 
                165                 170                 175     


Glu Gln Val Ile His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Glu Asp 
            180                 185                 190         


Leu Asn Gln Thr Glu Glu Gln Phe Val Ala His Cys Val Ala Glu Leu 
        195                 200                 205             


Glu Ala Leu Ile Glu Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Ile Leu Gly Ala Gly Gly Phe Val Pro Pro Pro Ala Gly 
225                 230                 235                 240 


Tyr Trp Glu Ala Ile Gln Thr Val Leu Asn Lys His Asp Ile Leu Leu 
                245                 250                 255     


Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met Phe 
            260                 265                 270         


Gly Ser Asp His Tyr Gly Leu Glu Pro Asp Ile Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Ile Val Ser Asp 
    290                 295                 300                 


Lys Val Trp Lys Val Leu Glu Gln Gly Thr Asp Glu Asn Gly Pro Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Leu Asp Glu Leu Asn Leu Val Ser Asn Ala 
            340                 345                 350         


Gly Glu Val Gly Ala Tyr Leu Asn Ala Thr Met Ala Glu Ala Leu Ser 
        355                 360                 365             


Gln His Ala Asn Val Gly Asp Val Arg Gly Glu Gly Leu Leu Cys Ala 
    370                 375                 380                 


Val Glu Phe Val Lys Asp Arg Asp Ser Arg Thr Phe Phe Asp Ala Ala 
385                 390                 395                 400 


Asp Lys Ile Gly Pro Gln Ile Ser Ala Lys Leu Leu Glu Gln Asp Lys 
                405                 410                 415     


Ile Ile Ala Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Phe Cys Leu Thr Arg Ala Glu Ala Asp Gln Val Val Glu Gly Thr 
        435                 440                 445             


Leu Arg Ala Val Lys Ala Val Leu Gly 
    450                 455         


<210>  53
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  53

Met Leu Lys Asn Asp Gln Leu Asp Gln Trp Asp Arg Asp Asn Phe Phe 
1               5                   10                  15      


His Pro Ser Thr His Leu Ala Gln His Ala Arg Gly Glu Ser Ala Asn 
            20                  25                  30          


Arg Val Ile Lys Thr Ala Ser Gly Val Phe Ile Glu Asp Arg Asp Gly 
        35                  40                  45              


Thr Lys Leu Leu Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Gln Glu Ile Ala Glu Ala Ile Ala Asp Gln Ala Arg Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Ser Phe Val Gly His Gly Thr Glu Ala Ser Ile 
                85                  90                  95      


Thr Leu Ala Lys Met Ile Leu Asp Arg Ala Pro Lys Asn Met Ser Lys 
            100                 105                 110         


Val Tyr Phe Gly Leu Gly Gly Ser Asp Ala Asn Glu Thr Asn Val Lys 
        115                 120                 125             


Leu Ile Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Phe His Gly Ser Gly Leu Val Thr Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Glu Leu Phe His Lys Lys Phe Asp Leu Pro Val 
                165                 170                 175     


Glu Gln Val Ile His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Glu Asp 
            180                 185                 190         


Leu Asn Gln Thr Glu Glu Gln Phe Val Ala His Cys Val Ala Glu Leu 
        195                 200                 205             


Glu Ala Leu Ile Glu Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Ile Leu Gly Ala Gly Gly Met Val Pro Pro Pro Ala Gly 
225                 230                 235                 240 


Tyr Trp Glu Ala Ile Gln Thr Val Leu Asn Lys His Asp Ile Leu Leu 
                245                 250                 255     


Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met Phe 
            260                 265                 270         


Gly Ser Asp His Tyr Gly Leu Glu Pro Asp Ile Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Ile Val Ser Asp 
    290                 295                 300                 


Lys Val Trp Lys Val Leu Glu Gln Gly Thr Asp Glu Asn Gly Pro Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Leu Asp Glu Leu Asn Leu Val Ser Asn Ala 
            340                 345                 350         


Gly Glu Val Gly Ala Tyr Leu Asn Ala Thr Met Ala Glu Ala Leu Ser 
        355                 360                 365             


Gln His Ala Asn Val Gly Asp Val Arg Gly Glu Gly Leu Leu Cys Ala 
    370                 375                 380                 


Val Glu Phe Val Lys Asp Arg Asp Ser Arg Thr Phe Phe Asp Ala Ala 
385                 390                 395                 400 


Asp Lys Ile Gly Pro Gln Ile Ser Ala Lys Leu Leu Glu Gln Asp Lys 
                405                 410                 415     


Ile Ile Ala Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Phe Cys Leu Thr Arg Ala Glu Ala Asp Gln Val Val Glu Gly Thr 
        435                 440                 445             


Leu Arg Ala Val Lys Ala Val Leu Gly 
    450                 455         


<210>  54
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  54

Met Leu Asn Gln Ser Asn Glu Leu Asn Ala Trp Asp Arg Asp His Phe 
1               5                   10                  15      


Phe His Pro Ser Thr His Met Gly Thr His Ala Arg Gly Glu Ser Pro 
            20                  25                  30          


Thr Arg Ile Met Ala Gly Gly Glu Gly Val Thr Val Trp Asp Asn Asn 
        35                  40                  45              


Gly Arg Lys Ser Ile Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Val 
    50                  55                  60                  


Gly Tyr Gly Arg Gln Lys Ile Ala Asp Ala Ile Ala Thr Gln Ala Lys 
65                  70                  75                  80  


Asn Leu Ala Tyr Tyr His Ala Phe Val Gly His Gly Thr Glu Ala Ser 
                85                  90                  95      


Ile Thr Leu Ala Lys Met Ile Ile Asp Arg Ala Pro Lys Gly Met Ser 
            100                 105                 110         


Arg Val Tyr Phe Gly Leu Ser Gly Ser Asp Ala Asn Glu Thr Asn Ile 
        115                 120                 125             


Lys Leu Ile Trp Tyr Tyr Asn Asn Val Leu Gly Arg Pro Glu Lys Lys 
    130                 135                 140                 


Lys Ile Ile Ser Arg Trp Arg Gly Phe His Gly Ser Gly Val Met Thr 
145                 150                 155                 160 


Gly Ser Leu Thr Gly Leu Asp Leu Phe His Asn Ala Phe Asp Leu Pro 
                165                 170                 175     


Arg Ala Pro Val Leu His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Thr 
            180                 185                 190         


Asp Arg Ser Met Ser Glu Glu Gln Phe Ser Gln His Cys Ala Asp Lys 
        195                 200                 205             


Leu Glu Glu Met Ile Leu Ala Glu Gly Pro Glu Thr Ile Ala Ala Phe 
    210                 215                 220                 


Ile Gly Glu Pro Ile Leu Gly Ala Gly Gly Phe Val Pro Pro Pro Ala 
225                 230                 235                 240 


Gly Tyr Trp Glu Lys Ile Gln Ala Val Leu Lys Lys Tyr Asp Val Leu 
                245                 250                 255     


Leu Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met 
            260                 265                 270         


Phe Gly Ser Asp His Tyr Gly Ile Lys Pro Asp Leu Ile Thr Ile Ala 
        275                 280                 285             


Lys Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Val Ile Val Ala 
    290                 295                 300                 


Asp Arg Val Trp Gln Val Leu Val Gln Gly Ser Asp Lys Leu Gly Ser 
305                 310                 315                 320 


Leu Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Cys Val Ala Ala 
                325                 330                 335     


Gly Val Ala Asn Leu Glu Leu Ile Asp Glu Met Asp Leu Val Thr Asn 
            340                 345                 350         


Ala Gly Glu Thr Gly Ala Tyr Phe Arg Ala Glu Leu Ala Lys Ala Val 
        355                 360                 365             


Gly Gly His Lys Asn Val Gly Glu Val Arg Gly Asp Gly Met Leu Ala 
    370                 375                 380                 


Ala Val Glu Phe Val Ala Asp Lys Asp Asp Arg Val Phe Phe Asp Ala 
385                 390                 395                 400 


Ser Gln Lys Ile Gly Pro Gln Val Ala Thr Ala Leu Ala Ala Ser Gly 
                405                 410                 415     


Val Ile Gly Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Leu Cys Leu Thr Arg Glu Gln Ala Asp Ile Val Val Ser Lys Thr 
        435                 440                 445             


Ala Asp Ala Val Lys Ser Val Phe Ala Asn Leu 
    450                 455                 


<210>  55
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  55

Met Leu Asn Gln Ser Asn Glu Leu Asn Ala Trp Asp Arg Asp His Phe 
1               5                   10                  15      


Phe His Pro Ser Thr His Met Gly Thr His Ala Arg Gly Glu Ser Pro 
            20                  25                  30          


Thr Arg Ile Met Ala Gly Gly Glu Gly Val Thr Val Trp Asp Asn Asn 
        35                  40                  45              


Gly Arg Lys Ser Ile Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Val 
    50                  55                  60                  


Gly Tyr Gly Arg Gln Lys Ile Ala Asp Ala Ile Ala Thr Gln Ala Lys 
65                  70                  75                  80  


Asn Leu Ala Tyr Tyr His Ala Phe Val Gly His Gly Thr Glu Ala Ser 
                85                  90                  95      


Ile Thr Leu Ala Lys Met Ile Ile Asp Arg Ala Pro Lys Gly Met Ser 
            100                 105                 110         


Arg Val Tyr Phe Gly Leu Ser Gly Ser Asp Ala Asn Glu Thr Asn Ile 
        115                 120                 125             


Lys Leu Ile Trp Tyr Tyr Asn Asn Val Leu Gly Arg Pro Glu Lys Lys 
    130                 135                 140                 


Lys Ile Ile Ser Arg Trp Arg Gly Phe His Gly Ser Gly Val Met Thr 
145                 150                 155                 160 


Gly Ser Leu Thr Gly Leu Asp Leu Phe His Asn Ala Phe Asp Leu Pro 
                165                 170                 175     


Arg Ala Pro Val Leu His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Thr 
            180                 185                 190         


Asp Arg Ser Met Ser Glu Glu Gln Phe Ser Gln His Cys Ala Asp Lys 
        195                 200                 205             


Leu Glu Glu Met Ile Leu Ala Glu Gly Pro Glu Thr Ile Ala Ala Phe 
    210                 215                 220                 


Ile Gly Glu Pro Ile Leu Gly Ala Gly Gly Met Val Pro Pro Pro Ala 
225                 230                 235                 240 


Gly Tyr Trp Glu Lys Ile Gln Ala Val Leu Lys Lys Tyr Asp Val Leu 
                245                 250                 255     


Leu Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met 
            260                 265                 270         


Phe Gly Ser Asp His Tyr Gly Ile Lys Pro Asp Leu Ile Thr Ile Ala 
        275                 280                 285             


Lys Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Val Ile Val Ala 
    290                 295                 300                 


Asp Arg Val Trp Gln Val Leu Val Gln Gly Ser Asp Lys Leu Gly Ser 
305                 310                 315                 320 


Leu Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Cys Val Ala Ala 
                325                 330                 335     


Gly Val Ala Asn Leu Glu Leu Ile Asp Glu Met Asp Leu Val Thr Asn 
            340                 345                 350         


Ala Gly Glu Thr Gly Ala Tyr Phe Arg Ala Glu Leu Ala Lys Ala Val 
        355                 360                 365             


Gly Gly His Lys Asn Val Gly Glu Val Arg Gly Asp Gly Met Leu Ala 
    370                 375                 380                 


Ala Val Glu Phe Val Ala Asp Lys Asp Asp Arg Val Phe Phe Asp Ala 
385                 390                 395                 400 


Ser Gln Lys Ile Gly Pro Gln Val Ala Thr Ala Leu Ala Ala Ser Gly 
                405                 410                 415     


Val Ile Gly Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Leu Cys Leu Thr Arg Glu Gln Ala Asp Ile Val Val Ser Lys Thr 
        435                 440                 445             


Ala Asp Ala Val Lys Ser Val Phe Ala Asn Leu 
    450                 455                 


<210>  56
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tag

<400>  56

Ser His His His His His His 
1               5           


<210>  57
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  57

Met Leu Lys Asn Asp Gln Leu Asp Gln Trp Asp Arg Asp Asn Phe Phe 
1               5                   10                  15      


His Pro Ser Thr His Leu Ala Gln His Ala Arg Gly Glu Ser Ala Asn 
            20                  25                  30          


Arg Val Ile Lys Thr Ala Ser Gly Val Phe Ile Glu Asp Arg Asp Gly 
        35                  40                  45              


Thr Lys Leu Leu Asp Ala Phe Ala Gly Leu Phe Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Gln Glu Ile Ala Glu Ala Ile Ala Asp Gln Ala Arg Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Ser Phe Val Gly His Gly Thr Glu Ala Ser Ile 
                85                  90                  95      


Thr Leu Ala Lys Met Ile Leu Asp Arg Ala Pro Lys Asn Met Ser Lys 
            100                 105                 110         


Val Tyr Phe Gly Leu Gly Gly Ser Asp Ala Asn Glu Thr Asn Val Lys 
        115                 120                 125             


Leu Ile Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Tyr His Gly Ser Gly Leu Val Thr Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Glu Leu Phe His Lys Lys Phe Asp Leu Pro Val 
                165                 170                 175     


Glu Gln Val Ile His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Glu Asp 
            180                 185                 190         


Leu Asn Gln Thr Glu Glu Gln Phe Val Ala His Cys Val Ala Glu Leu 
        195                 200                 205             


Glu Ala Leu Ile Glu Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Ile Leu Gly Gly Gly Gly Ile Val Pro Pro Pro Ala Gly 
225                 230                 235                 240 


Tyr Trp Glu Ala Ile Gln Thr Val Leu Asn Lys His Asp Ile Leu Leu 
                245                 250                 255     


Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met Phe 
            260                 265                 270         


Gly Ser Asp His Tyr Gly Leu Glu Pro Asp Ile Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Ile Val Ser Asp 
    290                 295                 300                 


Lys Val Trp Lys Val Leu Glu Gln Gly Thr Asp Glu Asn Gly Pro Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Leu Asp Glu Leu Asn Leu Val Ser Asn Ala 
            340                 345                 350         


Gly Glu Val Gly Ala Tyr Leu Asn Ala Thr Met Ala Glu Ala Leu Ser 
        355                 360                 365             


Gln His Ala Asn Val Gly Asp Val Arg Gly Glu Gly Leu Leu Cys Ala 
    370                 375                 380                 


Val Glu Phe Val Lys Asp Arg Asp Ser Arg Thr Phe Phe Asp Ala Ala 
385                 390                 395                 400 


Asp Lys Ile Gly Pro Gln Ile Ser Ala Lys Leu Leu Glu Gln Asp Lys 
                405                 410                 415     


Ile Ile Ala Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Phe Cys Leu Thr Arg Ala Glu Ala Asp Gln Val Val Glu Gly Thr 
        435                 440                 445             


Leu Arg Ala Val Lys Ala Val Leu Gly 
    450                 455         


<210>  58
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  58

Met Leu Lys Asn Asp Pro Leu Glu Gln Trp Asp Arg Asp His Phe Leu 
1               5                   10                  15      


His Pro Ser Thr His Leu Ala Glu Phe Ala Arg Gly Asn Val Ala His 
            20                  25                  30          


Arg Ile Val Ser Gly Gly Glu Gly Ser His Ile Val Asp Arg Asn Gly 
        35                  40                  45              


Thr Arg Leu Leu Asp Gly Phe Ala Gly Leu Trp Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Arg Glu Ile Ala Asp Ala Ile Ala Lys Gln Ala Arg Glu 
65                  70                  75                  80  


Leu Ser Tyr Tyr His Ser Phe Val Gly His Gly Thr Glu Ala Ser Val 
                85                  90                  95      


Thr Leu Ala His Met Ile Leu Glu Arg Ala Pro Ala Asn Met Ser Lys 
            100                 105                 110         


Val Phe Phe Gly Leu Gly Gly Ser Asp Ala Asn Glu Thr Asn Ile Lys 
        115                 120                 125             


Leu Ile Trp Tyr Met Asn Asn Ile Leu Gly Arg Pro Gly Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Phe His Gly Ser Gly Leu Met Ser Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Pro Leu Phe His Lys Ala Phe Asp Leu Pro Leu 
                165                 170                 175     


Ala Pro Ile Leu His Thr Glu Ala Pro Tyr Tyr Tyr Arg Arg Pro Asn 
            180                 185                 190         


Ala Asp Met Ser Glu Glu Ala Phe Ser Ala Trp Cys Ala Ser Glu Leu 
        195                 200                 205             


Glu Ala Met Ile Gln Arg Glu Gly Pro Asp Thr Ile Ala Ala Phe Trp 
    210                 215                 220                 


Ala Glu Pro Val Leu Gly Ala Gly Gly Met Val Pro Pro Pro Glu Gly 
225                 230                 235                 240 


Tyr Trp Ala Ala Ile Gln Glu Val Leu Asp Arg His Asp Ile Leu Leu 
                245                 250                 255     


Val Ala Asp Glu Val Ile Thr Gly Phe Gly Arg Leu Gly Thr Met Phe 
            260                 265                 270         


Gly Ser Asp His Tyr Gly Met Lys Pro Asp Val Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Val Leu Ser Glu 
    290                 295                 300                 


Lys Val Trp Lys Val Leu Glu Gln Gly Thr Asp Glu Met Gly Ala Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Ile Asp Glu Leu Gly Leu Ile Asp Asn Ala 
            340                 345                 350         


Ala Glu Val Gly Ala His Leu Arg Ala Gly Met Arg Asp Ala Leu Gly 
        355                 360                 365             


Glu His Pro Asn Val Gly Asp Ile Arg Gly Glu Gly Met Leu Cys Ala 
    370                 375                 380                 


Val Glu Leu Val Ser Asp Arg Glu Ser Lys Glu Gly Phe Asp Pro Ser 
385                 390                 395                 400 


Arg Lys Val Thr Val Asn Ala Val Ala His Leu Met Glu Asn Gly Val 
                405                 410                 415     


Ile Gly Arg Ala Met Pro His Ser Glu Thr Ile Gly Phe Ala Pro Pro 
            420                 425                 430         


Phe Cys Leu Thr Arg Asp Glu Ala Asp Glu Ile Val Ala Lys Thr Ala 
        435                 440                 445             


Ala Ala Val Lys Ala Val Leu Gly 
    450                 455     


<210>  59
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  59

Met Leu Thr Asn Asp Gln Leu Ser Gln Trp Asp Gln Asp His Phe Phe 
1               5                   10                  15      


His Pro Ser Thr Ala Leu Gly Ala His Ala Arg Gly Glu Ala Pro Gly 
            20                  25                  30          


Met Val Val Gln Thr Ala Glu Gly Cys His Ile Thr Asp Arg Asn Gly 
        35                  40                  45              


Asn Arg Met Leu Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Ile Gly 
    50                  55                  60                  


Tyr Gly Arg Gln Glu Val Ala Glu Ala Ile Ala Ala Gln Ala Arg Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Ser Phe Met Gly Asn Gly Thr Glu Ala Ser Ile 
                85                  90                  95      


Thr Leu Ala Lys Met Val Thr Glu Arg Ala Pro Glu Gly Met Asn Arg 
            100                 105                 110         


Val Tyr Phe Gly Gln Gly Gly Ser Asp Ala Asn Glu Thr Asn Ile Lys 
        115                 120                 125             


Leu Val Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Val Ser Arg Trp Arg Gly Phe His Gly Ser Gly Leu Met Ser Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Ser Leu Phe His Arg Lys Phe Asp Leu Pro Leu 
                165                 170                 175     


Asp Lys Val Leu His Thr Thr Ala Pro Tyr Tyr Phe Gln Arg Glu Asn 
            180                 185                 190         


Val Ala Gln Ser Glu Gln Glu Phe Thr Ala Gln Cys Val Ala Asp Leu 
        195                 200                 205             


Glu Glu Leu Ile Ala Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Ala Glu Pro Val Ile Gly Ala Gly Gly Met Val Pro Pro Pro Glu Gly 
225                 230                 235                 240 


Tyr Trp Asn Ala Ile Gln Pro Val Leu Lys Arg His Asp Ile Leu Leu 
                245                 250                 255     


Ile Ala Asp Glu Val Ile Thr Gly Phe Gly Arg Leu Gly Ala Met Phe 
            260                 265                 270         


Gly Ser Pro Leu Tyr Gly Ile Glu Pro Asp Ile Met Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Ile Val His Asp 
    290                 295                 300                 


Arg Val Trp Asp Val Leu Ala Arg Gly Thr Asp Glu Asn Gly Pro Leu 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Thr Leu Leu Asp Thr Leu Gly Leu Val Asp Asn Ala 
            340                 345                 350         


Ala Asp Val Gly Pro Tyr Leu Thr Ala Gln Met Arg Ala Ala Met Gln 
        355                 360                 365             


Asp His Ala His Val Gly Asp Ile Arg Gly Val Gly Met Leu Thr Ala 
    370                 375                 380                 


Val Glu Leu Val Ala Asp Arg Asp Lys Gly Ser Gly Val Gly Ala Gly 
385                 390                 395                 400 


Phe Asp Pro Ala Ala Lys Ile Val Pro Gln Ile Ser Ala Ala Met Ala 
                405                 410                 415     


Lys His Gly Val Ile Ala Arg Ala Met Pro Gln Ala Asp Ile Val Gly 
            420                 425                 430         


Phe Ser Pro Pro Leu Cys Leu Thr Arg Ala Glu Ala Asp Thr Ile Val 
        435                 440                 445             


Ser Val Thr Ala Glu Ala Val Ala Glu Val Leu Gly 
    450                 455                 460 


<210>  60
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  60

Met Leu Asp His Pro Ala Pro Ala Ser Asn Ala Phe Asp Ser Trp Asp 
1               5                   10                  15      


Arg Asp His Phe Phe His Pro Ser Thr His Met Gly Gln His Ala Arg 
            20                  25                  30          


Gly Glu Thr Pro Asn Arg Ile Ile Thr Gly Ala Glu Gly Val Tyr Ile 
        35                  40                  45              


Val Asp Arg Glu Gly Arg Arg Ser Leu Asp Ala Phe Gly Gly Leu Trp 
    50                  55                  60                  


Cys Val Asn Val Gly Tyr Gly Arg Ser Lys Ile Thr Asp Ala Ile Ala 
65                  70                  75                  80  


Glu Gln Ala Ser Lys Leu Ala Tyr Tyr His Ala Phe Ala Gly His Gly 
                85                  90                  95      


Ser Glu Pro Ser Ile Arg Leu Ala Arg Met Val Ile Glu Arg Ala Pro 
            100                 105                 110         


Ala Gly Met Ser Arg Val Phe Phe Gly Leu Ser Gly Ser Asp Ala Asn 
        115                 120                 125             


Glu Thr Asn Ile Lys Leu Val Trp Tyr Ile Asn Asn Val Leu Gly Arg 
    130                 135                 140                 


Pro Gln Lys Lys Lys Ile Ile Ser Arg Trp Arg Gly Phe His Gly Ser 
145                 150                 155                 160 


Gly Val Met Thr Gly Ser Leu Thr Gly Leu Ala Gly Phe His Lys Leu 
                165                 170                 175     


Phe Asp Leu Pro Arg Ala Pro Ile Leu His Thr Glu Ala Pro Tyr Tyr 
            180                 185                 190         


Phe Arg Arg Glu Asp Arg Ser Met Ser Glu Glu Gln Phe Ser Gln His 
        195                 200                 205             


Cys Ala Asp Arg Leu Glu Glu Met Ile Leu Thr Glu Gly Ala Asp Thr 
    210                 215                 220                 


Ile Ala Ala Phe Ile Gly Glu Pro Val Leu Gly Ala Gly Gly Met Val 
225                 230                 235                 240 


Pro Pro Pro Ala Gly Tyr Trp Pro Lys Ile Gln Ala Val Leu Lys Lys 
                245                 250                 255     


Tyr Asp Ile Met Leu Ile Ala Asp Glu Val Val Thr Gly Phe Gly Arg 
            260                 265                 270         


Leu Gly Ser Met Phe Gly Ser Asp His Tyr Gly Ile Glu Pro Asp Leu 
        275                 280                 285             


Ile Thr Ile Ala Lys Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly 
    290                 295                 300                 


Val Ile Val Ser Glu Lys Val Trp Arg Val Leu Glu Gln Gly Ser Asp 
305                 310                 315                 320 


Glu Phe Gly Pro Ile Gly His Gly Trp Thr Tyr Ser Ser His Pro Leu 
                325                 330                 335     


Cys Thr Ala Ala Gly Val Ala Asn Leu Glu Leu Val Asp Glu Leu Asp 
            340                 345                 350         


Leu Val Thr Asn Ala Arg Glu Thr Gly Ala Tyr Phe Asn Ala Ala Leu 
        355                 360                 365             


Lys Asp Ala Leu Ser Gly His Arg His Val Gly Glu Val Arg Gly Glu 
    370                 375                 380                 


Gly Leu Leu Ala Ala Val Glu Leu Val Arg Asp Arg Asp Asp Arg Thr 
385                 390                 395                 400 


Phe Phe Glu Ala Ser Glu Lys Val Gly Pro Arg Val Ala Ala Ala Met 
                405                 410                 415     


Leu Glu Arg Gly Val Ile Ala Arg Ala Met Pro Gln Gly Asp Ile Leu 
            420                 425                 430         


Gly Phe Ala Pro Pro Leu Cys Leu Thr Arg Glu Glu Ala Asp Ile Val 
        435                 440                 445             


Val Asp Ala Thr Arg Gly Ala Val Glu Ala Val Cys Ala Thr Leu Gly 
    450                 455                 460                 


<210>  61
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  61

Met Leu Arg Asn Asp Gln Leu Ala Glu Trp Asp Arg Glu Asn Phe Phe 
1               5                   10                  15      


His Ala Ser Thr His Leu Ala Ala His Ala Arg Gly Asp Thr Pro Thr 
            20                  25                  30          


Arg Ile Ile Thr Gly Gly Glu Gly Val Tyr Ile Gln Asp Arg Asp Gly 
        35                  40                  45              


Ala Lys Ile Leu Asp Gly Phe Ala Gly Leu Trp Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Arg Glu Ile Thr Asp Ala Ile Ala Ala Gln Val Ser Glu 
65                  70                  75                  80  


Leu Ser Tyr Tyr His Ala Phe Ala Gly His Gly Thr Glu Ala Ser Val 
                85                  90                  95      


Thr Leu Ala Lys Met Val Leu Asp Arg Ala Pro Asp Asn Met Ser Lys 
            100                 105                 110         


Val Tyr Phe Gly Leu Gly Gly Ser Asp Ala Asn Glu Thr Asn Ile Lys 
        115                 120                 125             


Leu Ile Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Phe His Gly Ser Gly Leu Met Thr Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Gly Leu Phe His Ala Lys Phe Asp Leu Pro Met 
                165                 170                 175     


Asp Gly Val Leu His Thr Glu Ala Pro His Tyr Leu His Arg Ala Asp 
            180                 185                 190         


Arg Asn Gln Thr Glu Glu Gln Phe Ser Ala Tyr Cys Ala Ala Lys Leu 
        195                 200                 205             


Glu Glu Met Ile Leu Ala Glu Gly Pro Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Ile Leu Gly Ala Gly Gly Met Val Pro Pro Pro Lys Gly 
225                 230                 235                 240 


Tyr Trp Ala Ala Ile Gln Ala Val Leu Arg Lys Tyr Asp Ile Leu Leu 
                245                 250                 255     


Val Val Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met Phe 
            260                 265                 270         


Gly Ser Glu His Tyr Gly Leu Lys Ala Asp Leu Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Ile Val Ser Lys 
    290                 295                 300                 


Lys Met Trp Ala Val Leu Glu Lys Gly Thr Asp Glu Asn Gly Ala Phe 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Ile Asp Asp Leu Gly Leu Ile Ala Asn Ala 
            340                 345                 350         


Ser Glu Thr Gly Ala Tyr Leu Lys Ser Ala Leu Gln Ala Ala Leu Gly 
        355                 360                 365             


Asp His Pro Asn Val Ala Glu Ile Arg Gly Glu Gly Met Leu Ala Ala 
    370                 375                 380                 


Val Glu Phe Cys Ala Asp Arg Asp Asp Leu Lys Gln Phe Asp Thr Ser 
385                 390                 395                 400 


Ala Thr Ile Gly Pro Arg Leu Ala Ala Glu Leu Leu Thr Arg Gly Val 
                405                 410                 415     


Ile Gly Arg Ala Met Pro Gln Ser Asp Thr Ile Gly Phe Ala Pro Pro 
            420                 425                 430         


Leu Cys Ile Thr Arg Ala Glu Val Asp Gln Ile Val Ala Ala Met Lys 
        435                 440                 445             


Gly Ala Val Asp Ala Val Leu Pro Ala 
    450                 455         


<210>  62
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  62

Met Leu Thr Asn Asp Gln Leu Asp Arg Phe Asp Arg Glu Asn Phe Phe 
1               5                   10                  15      


His Pro Ser Thr His Leu Ala Gln His Ala Arg Gly Glu Ser Pro Ser 
            20                  25                  30          


Arg Ile Val Lys Thr Ala Lys Gly Val Phe Ile Glu Asp Arg Asp Gly 
        35                  40                  45              


Asn Lys Leu Leu Asp Gly Phe Gly Gly Leu Trp Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Gln Glu Ser Ile Ile Glu Ala Ile Ala Glu Gln Ala Lys Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Ala Phe Ala Gly His Gly Thr Glu Ala Ser Ile 
                85                  90                  95      


Asn Leu Ala Lys Met Val Ile Asp Arg Ala Pro Asp His Met Ser Lys 
            100                 105                 110         


Val Tyr Phe Gly Leu Ser Gly Ser Asp Ala Asn Glu Thr Asn Ile Lys 
        115                 120                 125             


Leu Ile Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Phe His Gly Ser Gly Leu Met Thr Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Ala Gly Phe Gln Arg Lys Phe Asp Leu Pro Leu 
                165                 170                 175     


Glu Arg Val Phe His Thr Thr Ala Pro Tyr Tyr Tyr Arg Arg Lys Asp 
            180                 185                 190         


Leu Ala Met Ser Glu Ala Asp Phe Val Ala His Cys Val Ala Glu Leu 
        195                 200                 205             


Glu Met Arg Ile Glu Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Val Leu Gly Ala Gly Gly Met Val Pro Pro Pro Glu Gly 
225                 230                 235                 240 


Tyr Trp Lys Ala Ile Ser Ala Val Leu Glu Lys His Asp Ile Leu Leu 
                245                 250                 255     


Ile Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Ser Met Phe 
            260                 265                 270         


Gly Ser Asp His Tyr Gly Leu Lys Pro Asp Leu Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Thr Ile Val Ser Asp 
    290                 295                 300                 


Lys Val Trp Lys Val Leu Glu Gln Gly Thr Asp Glu Asn Gly Pro Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Ile Asp Glu Leu Gly Leu Val Lys Asn Ala 
            340                 345                 350         


Ala Glu Thr Gly Ala Tyr Leu Arg Ala Ala Met Lys Asp Ala Leu Ser 
        355                 360                 365             


Asp His Pro His Val Gly Asp Ile Arg Gly Glu Gly Met Leu Met Ala 
    370                 375                 380                 


Val Glu Phe Val Lys Asp Arg Glu Ser Arg Thr Phe Tyr Asp Pro Ser 
385                 390                 395                 400 


Glu Lys Val Gly Pro Asn Leu Ala Ala Ala Leu Ile Ser Glu Gly Val 
                405                 410                 415     


Ile Ala Arg Ala Met Pro Glu Gly Asp Ile Leu Gly Tyr Ala Pro Pro 
            420                 425                 430         


Leu Cys Leu Thr Arg Glu Glu Ala Asp Gln Ile Val Ala Ala Thr Lys 
        435                 440                 445             


Lys Ala Val Ile Ala Val Leu Gly 
    450                 455     


<210>  63
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  63

Met Leu Lys Asn Asp Gln Leu Asp Gln Trp Asp Arg Glu Asn Phe Phe 
1               5                   10                  15      


His Pro Ser Thr His Leu Ala Gln His Ala Arg Gly Asp Ser Ala Asn 
            20                  25                  30          


Arg Val Ile Lys Thr Ala Ser Gly Val Phe Ile Glu Asp Arg Asp Gly 
        35                  40                  45              


Asn Lys Leu Leu Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Gln Glu Ile Ala Asp Ala Ile Ala Asp Gln Ala Arg Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Ser Phe Val Gly His Gly Thr Glu Ala Ser Ile 
                85                  90                  95      


Thr Leu Ala Lys Met Ile Leu Asp Arg Ala Pro Ala Asn Met Ser Lys 
            100                 105                 110         


Val Tyr Phe Gly Leu Gly Gly Ser Asp Ala Asn Glu Thr Asn Val Lys 
        115                 120                 125             


Leu Ile Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Phe His Gly Ser Gly Leu Val Thr Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Glu Leu Phe His Lys Lys Phe Asp Leu Pro Val 
                165                 170                 175     


Asn Gln Val Ile His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Ala Asp 
            180                 185                 190         


Pro Asp Gln Ser Glu Ala Gln Phe Val Ala His Cys Ala Ala Glu Leu 
        195                 200                 205             


Glu Ala Leu Ile Glu Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Val Leu Gly Ala Gly Gly Met Val Pro Pro Pro Ala Gly 
225                 230                 235                 240 


Tyr Trp Glu Ala Ile Gln Ala Val Leu Arg Lys His Asp Ile Leu Leu 
                245                 250                 255     


Ile Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met Phe 
            260                 265                 270         


Gly Ser Asp His Tyr Gly Ile Glu Ala Asp Ile Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Ile Ile Ser Asp 
    290                 295                 300                 


Lys Val Trp Lys Val Leu Glu Gln Gly Thr Asp Glu Asn Gly Pro Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Ile Asp Arg Leu Asn Leu Val Gln Asn Ala 
            340                 345                 350         


Gly Glu Thr Gly Ala Tyr Leu Asn Ala Thr Met Thr Glu Ala Leu Ala 
        355                 360                 365             


Gly His Pro Asn Val Gly Glu Val Arg Gly Ala Gly Met Leu Cys Ala 
    370                 375                 380                 


Val Glu Phe Val Lys Asp Lys Asp Ser Arg Leu Phe Phe Asp Ala Ala 
385                 390                 395                 400 


Asp Lys Ile Gly Pro Gln Ile Ser Ala Lys Leu Leu Glu Gln Asp Lys 
                405                 410                 415     


Val Ile Ala Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro 
            420                 425                 430         


Pro Phe Cys Leu Ser Arg Ala Glu Ala Asp Gln Val Val Asp Ala Thr 
        435                 440                 445             


Leu Arg Ala Val Arg Thr Val Leu Gly 
    450                 455         


<210>  64
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Transaminase

<400>  64

Met Leu Thr Asn Asp Gln Leu Ser Gln Trp Asp Arg Glu Asn Phe Phe 
1               5                   10                  15      


His Pro Ser Thr His Leu Ala Gln His Ala Arg Gly Glu Thr Ala Thr 
            20                  25                  30          


Arg Val Ile Thr Thr Gly Gln Gly Cys His Ile Glu Asp Arg Asp Gly 
        35                  40                  45              


Thr Lys Leu Leu Asp Ala Phe Ala Gly Leu Trp Cys Val Asn Val Gly 
    50                  55                  60                  


Tyr Gly Arg Thr Glu Ile Ala Asp Ala Ile Ala Ala Gln Ala Lys Glu 
65                  70                  75                  80  


Leu Ala Tyr Tyr His Ala Phe Val Gly His Gly Thr Glu Ala Ser Ile 
                85                  90                  95      


Thr Leu Ser Lys Met Ile Leu Asp Arg Ala Pro Ala His Met Ser Lys 
            100                 105                 110         


Val Tyr Phe Gly Leu Ser Gly Ser Asp Ala Asn Glu Thr Asn Ile Lys 
        115                 120                 125             


Leu Ile Trp Tyr Tyr Asn Asn Ile Leu Gly Arg Pro Glu Lys Lys Lys 
    130                 135                 140                 


Ile Ile Ser Arg Trp Arg Gly Phe His Gly Ser Gly Leu Met Thr Gly 
145                 150                 155                 160 


Ser Leu Thr Gly Leu Glu Leu Phe His Lys Lys Phe Asp Leu Pro Leu 
                165                 170                 175     


Ala Gln Val Ile His Thr Glu Ala Pro Tyr Tyr Phe Arg Arg Pro Asp 
            180                 185                 190         


Leu Ala Met Ser Glu Glu Ala Phe Ser Ala Tyr Cys Ala Ala Glu Leu 
        195                 200                 205             


Glu Gln Leu Ile Glu Arg Glu Gly Ala Asp Thr Ile Ala Ala Phe Ile 
    210                 215                 220                 


Gly Glu Pro Val Leu Gly Ala Gly Gly Met Val Pro Pro Pro Lys Gly 
225                 230                 235                 240 


Tyr Trp Glu Ala Ile Gln Pro Ile Leu Glu Lys His Asp Ile Leu Leu 
                245                 250                 255     


Val Ala Asp Glu Val Val Thr Gly Phe Gly Arg Leu Gly Thr Met Phe 
            260                 265                 270         


Gly Ser Asp His Tyr Gly Leu Lys Pro Asp Leu Ile Thr Ile Ala Lys 
        275                 280                 285             


Gly Leu Thr Ser Ala Tyr Ala Pro Leu Ser Gly Ser Ile Val Gly Asp 
    290                 295                 300                 


Lys Met Trp Lys Val Leu Glu Gln Gly Thr Asp Glu Asn Gly Pro Ile 
305                 310                 315                 320 


Gly His Gly Trp Thr Tyr Ser Ala His Pro Ile Gly Ala Ala Ala Gly 
                325                 330                 335     


Val Ala Asn Leu Lys Leu Ile Asp Asp Met Asn Leu Val Ala Asn Ala 
            340                 345                 350         


Gly Glu Thr Gly Ala His Phe Arg Lys Ala Met Thr Asp Ala Leu Gly 
        355                 360                 365             


Asp His Ala Lys Val Gly Asp Ile Arg Gly Glu Gly Met Leu Cys Ala 
    370                 375                 380                 


Val Glu Leu Val Asp Asp Lys Asp Asn Arg Thr Phe Phe Asp Pro Ser 
385                 390                 395                 400 


Gln Lys Val Gly Ala Gln Ile Ala Ser Ala Leu Leu Ser Lys Gly Val 
                405                 410                 415     


Ile Ala Arg Ala Met Pro Gln Gly Asp Ile Leu Gly Phe Ala Pro Pro 
            420                 425                 430         


Leu Cys Leu Thr Pro Ala Glu Ala Glu Glu Val Ala Thr Lys Thr Gly 
        435                 440                 445             


Glu Ala Val Arg Asp Val Leu Gly 
    450                 455     

