                         SEQUENCE LISTING

<110>  Crucell Holland B.V.
       Wunderlich, Kerstin
       Custers, Jerome
       Vellinga, Jort
       Sanders, Barbara

 
<120>  Recombinant Adenovirus Expressing Two Transgenes With A Bidirectional Promoter

<130>  0255 WO 00 ORD

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  1958
<212>  DNA
<213>  Mouse cytomegalovirus

<400>  1
cacggccaag gtcagcaccg cagcttttat cctgaagggc cgtgggggac ctggaggaga       60

agaagggcct ggctgagtgg gtgccttcag tatgcagaag ccccgtgctc cccgaactca      120

gttgcagcca ggtgaggaga agggcacaga gcgggagaag acctcaggta ccagaggccc      180

ggcctggggc aaggcctgaa ccttgagctg gggagccaga gtgaccgggg caggcagcag      240

gacgcacctc cttctcgcag tctctaagca gccagctctt gcagggccta tttatgtgtt      300

aacgtaggta gggtcgtatc gagccgcggt ccgtcctgct ctgggctcga atggcatggg      360

ggacagcaat tatatggtta actccgcccg ttttatgact agaaccaata gtttttaatg      420

ccaaatgcac tgaaatcccc taatttgcaa agccaaacgc cccctatgtg agtaatacgg      480

ggacttttta cccaatttcc cacgcggaaa gccccctaat acactcatat ggcatatgaa      540

tcagcacggt catgcactct aatggcggcc catagggact ttccacatag ggggcgttca      600

ccatttccca gcataggggt ggtgactcaa tggcctttac ccaagtacat tgggtcaatg      660

ggaggtaagc caatgggttt ttcccattac tggcaagcac actgagtcaa atgggacttt      720

ccactgggtt ttgcccaagt acattgggtc aatgggaggt gagccaatgg gaaaaaccca      780

ttgctgccaa gtacactgac tcaataggga ctttccaatg ggtttttcca ttgttggcaa      840

gcatataagg tcaatgtggg tgagtcaata gggactttcc attgtattct gcccagtaca      900

taaggtcaat agggggtgaa tcaacaggaa agtcccattg gagccaagta cactgcgtca      960

atagggactt tccattgggt tttgcccagt acataaggtc aataggggat gagtcaatgg     1020

gaaaaaccca ttggagccaa gtacactgac tcaataggga ctttccattg ggttttgccc     1080

agtacataag gtcaataggg ggtgagtcaa caggaaagtt ccattggagc caagtacatt     1140

gagtcaatag ggactttcca atgggttttg cccagtacat aaggtcaatg ggaggtaagc     1200

caatgggttt ttcccattac tggcacgtat actgagtcat tagggacttt ccaatgggtt     1260

ttgcccagta cataaggtca ataggggtga atcaacagga aagtcccatt ggagccaagt     1320

acactgagtc aatagggact ttccattggg ttttgcccag tacaaaaggt caataggggg     1380

tgagtcaatg ggtttttccc attattggca cgtacataag gtcaataggg gtgagtcatt     1440

gggtttttcc agccaattta atttaaacgc catgtacttt cccaccattg acgtcaatgg     1500

gctattgaaa ctaatgcaac gtgaccttta aacggtactt tcccatagct gattaatggg     1560

aaagtaccgt tctcgagcca atacacgtca atgggaagtg aaagggcagc caaaacgtaa     1620

caccgccccg gttttcccct ggaaattcca tattggcacg cattctattg gctgagctgc     1680

gttctacgtg ggtataagag gcgcgaccag cgtcggtacc gtcgcagtct tcggtctgac     1740

caccgtagaa cgcagagctc ctcgctgcag ctgcagaagt tggtcgtgag gcactgggca     1800

ggtaagtatc aaggttacaa gacaggttta aggagaccaa tagaaactgg gcttgtcgag     1860

acagagaaga ctcttgcgtt tctgataggc acctattggt cttactgaca tccactttgc     1920

ctttctctcc acaggtgtcc actcccagtt caattaca                             1958


<210>  2
<211>  1478
<212>  DNA
<213>  Mouse cytomegalovirus

<400>  2
gttaacgtag gtagggtcgt atcgagccgc ggtccgtcct gctctgggct cgaatggcat       60

gggggacagc aattatatgg ttaactccgc ccgttttatg actagaacca atagttttta      120

atgccaaatg cactgaaatc ccctaatttg caaagccaaa cgccccctat gtgagtaata      180

cggggacttt ttacccaatt tcccacgcgg aaagccccct aatacactca tatggcatat      240

gaatcagcac ggtcatgcac tctaatggcg gcccataggg actttccaca tagggggcgt      300

tcaccatttc ccagcatagg ggtggtgact caatggcctt tacccaagta cattgggtca      360

atgggaggta agccaatggg tttttcccat tactggcaag cacactgagt caaatgggac      420

tttccactgg gttttgccca agtacattgg gtcaatggga ggtgagccaa tgggaaaaac      480

ccattgctgc caagtacact gactcaatag ggactttcca atgggttttt ccattgttgg      540

caagcatata aggtcaatgt gggtgagtca atagggactt tccattgtat tctgcccagt      600

acataaggtc aatagggggt gaatcaacag gaaagtccca ttggagccaa gtacactgcg      660

tcaataggga ctttccattg ggttttgccc agtacataag gtcaataggg gatgagtcaa      720

tgggaaaaac ccattggagc caagtacact gactcaatag ggactttcca ttgggttttg      780

cccagtacat aaggtcaata gggggtgagt caacaggaaa gttccattgg agccaagtac      840

attgagtcaa tagggacttt ccaatgggtt ttgcccagta cataaggtca atgggaggta      900

agccaatggg tttttcccat tactggcacg tatactgagt cattagggac tttccaatgg      960

gttttgccca gtacataagg tcaatagggg tgaatcaaca ggaaagtccc attggagcca     1020

agtacactga gtcaataggg actttccatt gggttttgcc cagtacaaaa ggtcaatagg     1080

gggtgagtca atgggttttt cccattattg gcacgtacat aaggtcaata ggggtgagtc     1140

attgggtttt tccagccaat ttaatttaaa cgccatgtac tttcccacca ttgacgtcaa     1200

tgggctattg aaactaatgc aacgtgacct ttaaacggta ctttcccata gctgattaat     1260

gggaaagtac cgttctcgag ccaatacacg tcaatgggaa gtgaaagggc agccaaaacg     1320

taacaccgcc ccggttttcc cctggaaatt ccatattggc acgcattcta ttggctgagc     1380

tgcgttctac gtgggtataa gaggcgcgac cagcgtcggt accgtcgcag tcttcggtct     1440

gaccaccgta gaacgcagag ctcctcgctg cagctgca                             1478


<210>  3
<211>  183
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric intron

<400>  3
gaagttggtc gtgaggcact gggcaggtaa gtatcaaggt tacaagacag gtttaaggag       60

accaatagaa actgggcttg tcgagacaga gaagactctt gcgtttctga taggcaccta      120

ttggtcttac tgacatccac tttgcctttc tctccacagg tgtccactcc cagttcaatt      180

aca                                                                    183


<210>  4
<211>  297
<212>  DNA
<213>  Homo sapiens

<400>  4
acataaatag gccctgcaag agctggctgc ttagagactg cgagaaggag gtgcgtcctg       60

ctgcctgccc cggtcactct ggctccccag ctcaaggttc aggccttgcc ccaggccggg      120

cctctggtac ctgaggtctt ctcccgctct gtgcccttct cctcacctgg ctgcaactga      180

gttcggggag cacggggctt ctgcatactg aaggcaccca ctcagccagg cccttcttct      240

cctccaggtc ccccacggcc cttcaggata aaagctgcgg tgctgacctt ggccgtg         297


