                         SEQUENCE LISTING

<110>  Ganymed Pharmaceuticals AG
 
<120>  METHODS AND COMPOSITIONS FOR PREDICTION OF THERAPEUTIC EFFICACY OF CANCER TREATMENTS AND CANCER PROGNOSIS 

<130>  342-85

<160>  78   

<170>  PatentIn version 3.5


<210>  1
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Val Thr Ala Cys Gln Gly Leu Gly Phe Val Val Ser Leu Ile 
1               5                   10                  15      


Gly Ile Ala Gly Ile Ile Ala Ala Thr Cys Met Asp Gln Trp Ser Thr 
            20                  25                  30          


Gln Asp Leu Tyr Asn Asn Pro Val Thr Ala Val Phe Asn Tyr Gln Gly 
        35                  40                  45              


Leu Trp Arg Ser Cys Val Arg Glu Ser Ser Gly Phe Thr Glu Cys Arg 
    50                  55                  60                  


Gly Tyr Phe Thr Leu Leu Gly Leu Pro Ala Met Leu Gln Ala Val Arg 
65                  70                  75                  80  


Ala Leu Met Ile Val Gly Ile Val Leu Gly Ala Ile Gly Leu Leu Val 
                85                  90                  95      


Ser Ile Phe Ala Leu Lys Cys Ile Arg Ile Gly Ser Met Glu Asp Ser 
            100                 105                 110         


Ala Lys Ala Asn Met Thr Leu Thr Ser Gly Ile Met Phe Ile Val Ser 
        115                 120                 125             


Gly Leu Cys Ala Ile Ala Gly Val Ser Val Phe Ala Asn Met Leu Val 
    130                 135                 140                 


Thr Asn Phe Trp Met Ser Thr Ala Asn Met Tyr Thr Gly Met Gly Gly 
145                 150                 155                 160 


Met Val Gln Thr Val Gln Thr Arg Tyr Thr Phe Gly Ala Ala Leu Phe 
                165                 170                 175     


Val Gly Trp Val Ala Gly Gly Leu Thr Leu Ile Gly Gly Val Met Met 
            180                 185                 190         


Cys Ile Ala Cys Arg Gly Leu Ala Pro Glu Glu Thr Asn Tyr Lys Ala 
        195                 200                 205             


Val Ser Tyr His Ala Ser Gly His Ser Val Ala Tyr Lys Pro Gly Gly 
    210                 215                 220                 


Phe Lys Ala Ser Thr Gly Phe Gly Ser Asn Thr Lys Asn Lys Lys Ile 
225                 230                 235                 240 


Tyr Asp Gly Gly Ala Arg Thr Glu Asp Glu Val Gln Ser Tyr Pro Ser 
                245                 250                 255     


Lys His Asp Tyr Val 
            260     


<210>  2
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Thr Thr Thr Cys Gln Val Val Ala Phe Leu Leu Ser Ile Leu 
1               5                   10                  15      


Gly Leu Ala Gly Cys Ile Ala Ala Thr Gly Met Asp Met Trp Ser Thr 
            20                  25                  30          


Gln Asp Leu Tyr Asp Asn Pro Val Thr Ser Val Phe Gln Tyr Glu Gly 
        35                  40                  45              


Leu Trp Arg Ser Cys Val Arg Gln Ser Ser Gly Phe Thr Glu Cys Arg 
    50                  55                  60                  


Pro Tyr Phe Thr Ile Leu Gly Leu Pro Ala Met Leu Gln Ala Val Arg 
65                  70                  75                  80  


Ala Leu Met Ile Val Gly Ile Val Leu Gly Ala Ile Gly Leu Leu Val 
                85                  90                  95      


Ser Ile Phe Ala Leu Lys Cys Ile Arg Ile Gly Ser Met Glu Asp Ser 
            100                 105                 110         


Ala Lys Ala Asn Met Thr Leu Thr Ser Gly Ile Met Phe Ile Val Ser 
        115                 120                 125             


Gly Leu Cys Ala Ile Ala Gly Val Ser Val Phe Ala Asn Met Leu Val 
    130                 135                 140                 


Thr Asn Phe Trp Met Ser Thr Ala Asn Met Tyr Thr Gly Met Gly Gly 
145                 150                 155                 160 


Met Val Gln Thr Val Gln Thr Arg Tyr Thr Phe Gly Ala Ala Leu Phe 
                165                 170                 175     


Val Gly Trp Val Ala Gly Gly Leu Thr Leu Ile Gly Gly Val Met Met 
            180                 185                 190         


Cys Ile Ala Cys Arg Gly Leu Ala Pro Glu Glu Thr Asn Tyr Lys Ala 
        195                 200                 205             


Val Ser Tyr His Ala Ser Gly His Ser Val Ala Tyr Lys Pro Gly Gly 
    210                 215                 220                 


Phe Lys Ala Ser Thr Gly Phe Gly Ser Asn Thr Lys Asn Lys Lys Ile 
225                 230                 235                 240 


Tyr Asp Gly Gly Ala Arg Thr Glu Asp Glu Val Gln Ser Tyr Pro Ser 
                245                 250                 255     


Lys His Asp Tyr Val 
            260     


<210>  3
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  3

Asp Gln Trp Ser Thr Gln Asp Leu Tyr Asn 
1               5                   10  


<210>  4
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  4

Asn Asn Pro Val Thr Ala Val Phe Asn Tyr Gln 
1               5                   10      


<210>  5
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  5

Ser Thr Gln Asp Leu Tyr Asn Asn Pro Val Thr Ala Val Phe 
1               5                   10                  


<210>  6
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  6

Thr Asn Phe Trp Met Ser Thr Ala Asn Met Tyr Thr Gly 
1               5                   10              


<210>  7
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  7

Asp Ser Ala Lys Ala Asn Met Thr Leu Thr Ser Gly Ile 
1               5                   10              


<210>  8
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Asp Gln Trp Ser Thr Gln Asp Leu Tyr Asn Asn Pro Val Thr Ala 
1               5                   10                  15      


Val Phe Asn Tyr Gln Gly Leu Trp Arg Ser Cys Val Arg Glu Ser Ser 
            20                  25                  30          


Gly Phe Thr Glu Cys Arg Gly Tyr Phe Thr Leu Leu Gly Leu Pro Ala 
        35                  40                  45              


Met Leu Gln Ala Val Arg Ala 
    50                  55  


<210>  9
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  9

Phe Ala Leu Lys Cys Ile Arg Ile Gly Ser Met Glu Asp Ser Ala Lys 
1               5                   10                  15      


Ala Asn Met Thr Leu Thr Ser Gly 
            20                  


<210>  10
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  10

Ala Asn Met Leu Val Thr Asn Phe Trp Met Ser Thr Ala Asn Met Tyr 
1               5                   10                  15      


Thr Gly Met Gly Gly Met Val Gln Thr Val Gln Thr Arg Tyr Thr Phe 
            20                  25                  30          


Gly Ala Ala Leu Phe Val Gly Trp 
        35                  40  


<210>  11
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Asp Gln Trp Ser Thr Gln Asp Leu Tyr Asn Asn Pro Val Thr Ala 
1               5                   10                  15      


Val Phe Asn Tyr Gln Gly Leu Trp Arg Ser Cys Val Arg Glu Ser Ser 
            20                  25                  30          


Gly Phe Thr Glu Cys Arg Gly Tyr Phe Thr Leu Leu Gly Leu Pro Ala 
        35                  40                  45              


Met Leu Gln Ala Val Arg Ala Leu Met Ile Val Gly Ile Val Leu Gly 
    50                  55                  60                  


Ala Ile Gly Leu Leu Val Ser Ile Phe Ala Leu Lys Cys Ile Arg Ile 
65                  70                  75                  80  


Gly Ser Met Glu Asp Ser Ala Lys Ala Asn Met Thr Leu Thr Ser Gly 
                85                  90                  95      


Ile Met Phe Ile Val Ser Gly Leu Cys Ala Ile Ala Gly Val Ser Val 
            100                 105                 110         


Phe Ala Asn Met Leu Val Thr Asn Phe Trp Met Ser Thr Ala Asn Met 
        115                 120                 125             


Tyr Thr Gly Met Gly Gly Met Val Gln Thr Val Gln Thr Arg Tyr Thr 
    130                 135                 140                 


Phe Gly Ala Ala Leu Phe Val Gly Trp 
145                 150             


<210>  12
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Description of artificial sequence: Translation of PCR product

<400>  12

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  13
<211>  326
<212>  PRT
<213>  Artificial

<220>
<223>  Description of artificial sequence: Translation of PCR product

<400>  13

Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
1               5                   10                  15      


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
            20                  25                  30          


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
        35                  40                  45              


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
    50                  55                  60                  


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
65                  70                  75                  80  


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
                85                  90                  95      


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            100                 105                 110         


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                165                 170                 175     


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  14
<211>  466
<212>  PRT
<213>  Artificial

<220>
<223>  Description of artificial sequence: chimeric monoclonal antibody

<400>  14

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe 
        35                  40                  45              


Ser Ser Tyr Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Tyr Asp Tyr Pro Trp Phe Ala Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val 
    130                 135                 140                 


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    210                 215                 220                 


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
225                 230                 235                 240 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys 
465     


<210>  15
<211>  467
<212>  PRT
<213>  Artificial

<220>
<223>  Description of artificial sequence: chimeric monoclonal antibody

<400>  15

Met Asp Trp Leu Trp Asn Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      


Ile Gln Ala Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
            20                  25                  30          


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Lys Trp Met Gly Trp Ile Asn Thr Asn Thr Gly Glu Pro Thr Tyr Ala 
65                  70                  75                  80  


Glu Glu Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Phe Cys Ala Arg Leu Gly Phe Gly Asn Ala Met Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  16
<211>  465
<212>  PRT
<213>  Artificial

<220>
<223>  Description of artificial sequence: chimeric monoclonal antibody

<400>  16

Met Glu Trp Ile Trp Ile Phe Leu Phe Ile Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Tyr Ile Asn Trp Val Lys Gln Arg Thr Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Ser Tyr Gly Ala Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
    130                 135                 140                 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
145                 150                 155                 160 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
                165                 170                 175     


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
            180                 185                 190         


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
        195                 200                 205             


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
    210                 215                 220                 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
225                 230                 235                 240 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                245                 250                 255     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            260                 265                 270         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        275                 280                 285             


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    290                 295                 300                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
305                 310                 315                 320 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                325                 330                 335     


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
            340                 345                 350         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        355                 360                 365             


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
    370                 375                 380                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
385                 390                 395                 400 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                405                 410                 415     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            420                 425                 430         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        435                 440                 445             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455                 460                 


Lys 
465 


<210>  17
<211>  467
<212>  PRT
<213>  Artificial

<220>
<223>  Description of artificial sequence: chimeric monoclonal antibody

<400>  17

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Trp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asn Ile Tyr Pro Ser Asp Ser Tyr Thr Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Ser Trp Arg Gly Asn Ser Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  18
<211>  466
<212>  PRT
<213>  Artificial

<220>
<223>  Description of artificial sequence: chimeric monoclonal antibody

<400>  18

Met Glu Trp Arg Ile Phe Leu Phe Ile Leu Ser Gly Thr Ala Gly Val 
1               5                   10                  15      


His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro 
            20                  25                  30          


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        35                  40                  45              


Asp Tyr Val Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Glu Ile Tyr Pro Gly Ser Gly Ser Thr Tyr Tyr Asn Glu 
65                  70                  75                  80  


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr 
                85                  90                  95      


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            100                 105                 110         


Phe Cys Ala Arg Gly Val Leu Leu Arg Ala Met Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    130                 135                 140                 


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    210                 215                 220                 


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
225                 230                 235                 240 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys 
465     


<210>  19
<211>  469
<212>  PRT
<213>  Artificial

<220>
<223>  Description of artificial sequence: chimeric monoclonal antibody

<400>  19

Met Asp Trp Ile Trp Ile Met Leu His Leu Leu Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ile Gln Ser Gln Val His Leu Gln Gln Ser Gly Ser Glu Leu Arg Ser 
            20                  25                  30          


Pro Gly Ser Ser Val Lys Leu Ser Cys Lys Asp Phe Asp Ser Glu Val 
        35                  40                  45              


Phe Pro Phe Ala Tyr Met Ser Trp Ile Arg Gln Lys Pro Gly His Gly 
    50                  55                  60                  


Phe Glu Trp Ile Gly Asp Ile Leu Pro Ser Ile Gly Arg Thr Ile Tyr 
65                  70                  75                  80  


Gly Glu Lys Phe Glu Asp Lys Ala Thr Leu Asp Ala Asp Thr Val Ser 
                85                  90                  95      


Asn Thr Ala Tyr Leu Glu Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Ile Tyr Tyr Cys Ala Arg Gly Glu Gly Tyr Gly Ala Trp Phe Ala Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    210                 215                 220                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
225                 230                 235                 240 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly Lys 
465                 


<210>  20
<211>  240
<212>  PRT
<213>  Artificial

<220>
<223>  Description of artificial sequence: chimeric monoclonal antibody

<400>  20

Met Glu Ser Gln Thr Gln Val Leu Met Ser Leu Leu Phe Trp Val Ser 
1               5                   10                  15      


Gly Thr Cys Gly Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr 
            20                  25                  30          


Val Thr Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr 
        115                 120                 125             


Lys Leu Glu Leu Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  21
<211>  235
<212>  PRT
<213>  Artificial

<220>
<223>  Description of artificial sequence: chimeric monoclonal antibody

<400>  21

Met His Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
            20                  25                  30          


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly Thr Ser 
    50                  55                  60                  


Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg 
            100                 105                 110         


Ser Ser Tyr Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  22
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  Description of artificial sequence: chimeric monoclonal antibody

<400>  22

Met Glu Phe Gln Thr Gln Val Phe Val Phe Val Leu Leu Trp Leu Ser 
1               5                   10                  15      


Gly Val Asp Gly Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn 
        35                  40                  45              


Val Arg Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Ala Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp 
            100                 105                 110         


Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  23
<211>  240
<212>  PRT
<213>  Artificial

<220>
<223>  Description of artificial sequence: chimeric monoclonal antibody

<400>  23

Met Asp Ser Gln Ala Gln Val Leu Met Leu Leu Leu Leu Trp Val Ser 
1               5                   10                  15      


Gly Thr Cys Gly Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala 
            20                  25                  30          


Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr 
        115                 120                 125             


Lys Leu Glu Leu Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  24
<211>  240
<212>  PRT
<213>  Artificial

<220>
<223>  Description of artificial sequence: chimeric monoclonal antibody

<400>  24

Met Glu Ser Gln Thr Gln Val Leu Met Ser Leu Leu Phe Trp Val Ser 
1               5                   10                  15      


Gly Thr Cys Gly Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr 
            20                  25                  30          


Val Thr Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  25
<211>  239
<212>  PRT
<213>  Artificial

<220>
<223>  Description of artificial sequence: chimeric monoclonal antibody

<400>  25

Met Asp Ser Gln Ala Gln Val Leu Ile Leu Leu Leu Leu Trp Val Ser 
1               5                   10                  15      


Gly Thr Cys Gly Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala 
            20                  25                  30          


Val Ser Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys Lys Gln Ser Tyr Asn Leu Tyr Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  26
<211>  240
<212>  PRT
<213>  Artificial

<220>
<223>  Description of artificial sequence: chimeric monoclonal antibody

<400>  26

Met Asp Ser Gln Ala Gln Val Leu Met Leu Leu Leu Leu Trp Val Ser 
1               5                   10                  15      


Gly Thr Cys Gly Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala 
            20                  25                  30          


Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Ala Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr 
            100                 105                 110         


His Cys Gly Gln Gly Tyr Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  27
<211>  240
<212>  PRT
<213>  Artificial

<220>
<223>  Description of artificial sequence: chimeric monoclonal antibody

<400>  27

Met Asp Ser Gln Ala Gln Val Leu Met Leu Leu Leu Leu Trp Val Ser 
1               5                   10                  15      


Gly Thr Cys Gly Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala 
            20                  25                  30          


Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr 
        115                 120                 125             


Lys Leu Glu Leu Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  28
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  Description of artificial sequence: chimeric monoclonal antibody

<400>  28

Met Glu Ser Gln Thr Leu Val Phe Ile Ser Ile Leu Leu Trp Leu Tyr 
1               5                   10                  15      


Gly Ala Asp Gly Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser 
            20                  25                  30          


Met Ser Val Gly Glu Arg Val Thr Leu Thr Cys Lys Ala Ser Glu Asn 
        35                  40                  45              


Val Val Thr Tyr Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr 
            100                 105                 110         


Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  29
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  Description of artificial sequence: Translation of PCR product

<400>  29

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Pro Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  30
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Description of artificial sequence: Translation of PCR product

<400>  30

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Glu Pro Thr Tyr Ala Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Gly Phe Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  31
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  Description of artificial sequence: Translation of PCR product

<400>  31

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Tyr Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  32
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Description of artificial sequence: Translation of PCR product

<400>  32

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Tyr Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser Trp Arg Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  33
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Description of artificial sequence: Translation of PCR product

<400>  33

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Val Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Gly Ser Gly Ser Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Val Leu Leu Arg Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  34
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  Description of artificial sequence: Translation of PCR product

<400>  34

Gln Val His Leu Gln Gln Ser Gly Ser Glu Leu Arg Ser Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Asp Phe Asp Ser Glu Val Phe Pro Phe 
            20                  25                  30          


Ala Tyr Met Ser Trp Ile Arg Gln Lys Pro Gly His Gly Phe Glu Trp 
        35                  40                  45              


Ile Gly Asp Ile Leu Pro Ser Ile Gly Arg Thr Ile Tyr Gly Glu Lys 
    50                  55                  60                  


Phe Glu Asp Lys Ala Thr Leu Asp Ala Asp Thr Val Ser Asn Thr Ala 
65                  70                  75                  80  


Tyr Leu Glu Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Glu Gly Tyr Gly Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  35
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Description of artificial sequence: Translation of PCR product

<400>  35

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  36
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Description of artificial sequence: Translation of PCR product

<400>  36

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  37
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Description of artificial sequence: Translation of PCR product

<400>  37

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  38
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Description of artificial sequence: Translation of PCR product

<400>  38

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  39
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Description of artificial sequence: Translation of PCR product

<400>  39

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  40
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Description of artificial sequence: Translation of PCR product

<400>  40

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  41
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Description of artificial sequence: Translation of PCR product

<400>  41

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr His Cys Gly Gln 
                85                  90                  95      


Gly Tyr Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  42
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Description of artificial sequence: Translation of PCR product

<400>  42

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  43
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Description of artificial sequence: Translation of PCR product

<400>  43

Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Thr Cys Lys Ala Ser Glu Asn Val Val Thr Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Lys Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  44
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Epitope

<400>  44

Met Asp Gln Trp Ser Thr Gln Asp Leu Tyr Asn Asn Pro Val Thr 
1               5                   10                  15  


<210>  45
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Epitope

<400>  45

Ser Thr Gln Asp Leu Tyr Asn Asn Pro Val Thr Ala Val Phe Asn 
1               5                   10                  15  


<210>  46
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Epitope

<400>  46

Leu Tyr Asn Asn Pro Val Thr Ala Val Phe Asn Tyr Gln Gly Leu 
1               5                   10                  15  


<210>  47
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Epitope

<400>  47

Pro Val Thr Ala Val Phe Asn Tyr Gln Gly Leu Trp Arg Ser Cys 
1               5                   10                  15  


<210>  48
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Epitope

<400>  48

Val Phe Asn Tyr Gln Gly Leu Trp Arg Ser Cys Val Arg Glu Ser 
1               5                   10                  15  


<210>  49
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Epitope

<400>  49

Gln Gly Leu Trp Arg Ser Cys Val Arg Glu Ser Ser Gly Phe Thr 
1               5                   10                  15  


<210>  50
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Epitope

<400>  50

Arg Ser Cys Val Arg Glu Ser Ser Gly Phe Thr Glu Cys Arg Gly 
1               5                   10                  15  


<210>  51
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric monoclonal antibody

<400>  51

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Trp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asn Ile Tyr Pro Ser Asp Ser Tyr Thr Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Ser Trp Arg Gly Asn Ser Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  52
<211>  51
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  n may be C or T

<400>  52
tgggatggag aaggtgggat ccaaanggga gaatttctgg gattttccat t                51


<210>  53
<211>  51
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  n may be A or G

<400>  53
cccctaaacc cgcaacagtt gttacnggtt ctggtcatgc aagctctacc c                51


<210>  54
<211>  51
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  n may be A or G

<400>  54
caacactact aaggcttctt tgggangggg aagtagggat aggtaagagg a                51


<210>  55
<211>  51
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  n may be A or G

<400>  55
aattccacca gcacagccac tcactntgtg ctcatctcac tcctccagca g                51


<210>  56
<211>  51
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  n may be A or G

<400>  56
aggtccagag ccagtgttct tgttcnacct gaaagtaatg gctctgggtt g                51


<210>  57
<211>  51
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  n may be A or G

<400>  57
ctttcagccc caatccaagg gttgtngctg gaactttcca tcagttcttc c                51


<210>  58
<211>  51
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  n may be A or C

<400>  58
ctagcaactc caggctagag ggtcancgcg tctatgcgag gccgggtggg c                51


<210>  59
<211>  51
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  n may be C or T

<400>  59
atcccgtact gaagttcgtg cgcaangtgc cctgggaatt tggcgacgta a                51


<210>  60
<211>  51
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  n may be G or T

<400>  60
cggctcctac ttctgcaggg ggcttnttgg gagtaaaaat gtgtcttcag a                51


<210>  61
<211>  2429
<212>  DNA
<213>  Homo sapiens

<400>  61
ctcttttcta agcttgtctc ttaaaaccca ctggacgttg gcacagtgct gggatgacta       60

tggagaccca aatgtctcag aatgtatgtc ccagaaacct gtggctgctt caaccattga      120

cagttttgct gctgctggct tctgcagaca gtcaagctgc agctccccca aaggctgtgc      180

tgaaacttga gcccccgtgg atcaacgtgc tccaggagga ctctgtgact ctgacatgcc      240

agggggctcg cagccctgag agcgactcca ttcagtggtt ccacaatggg aatctcattc      300

ccacccacac gcagcccagc tacaggttca aggccaacaa caatgacagc ggggagtaca      360

cgtgccagac tggccagacc agcctcagcg accctgtgca tctgactgtg ctttccgaat      420

ggctggtgct ccagacccct cacctggagt tccaggaggg agaaaccatc atgctgaggt      480

gccacagctg gaaggacaag cctctggtca aggtcacatt cttccagaat ggaaaatccc      540

agaaattctc ccatttggat cccaccttct ccatcccaca agcaaaccac agtcacagtg      600

gtgattacca ctgcacagga aacataggct acacgctgtt ctcatccaag cctgtgacca      660

tcactgtcca agtgcccagc atgggcagct cttcaccaat ggggatcatt gtggctgtgg      720

tcattgcgac tgctgtagca gccattgttg ctgctgtagt ggccttgatc tactgcagga      780

aaaagcggat ttcagccaat tccactgatc ctgtgaaggc tgcccaattt gagccacctg      840

gacgtcaaat gattgccatc agaaagagac aacttgaaga aaccaacaat gactatgaaa      900

cagctgacgg cggctacatg actctgaacc ccagggcacc tactgacgat gataaaaaca      960

tctacctgac tcttcctccc aacgaccatg tcaacagtaa taactaaaga gtaacgttat     1020

gccatgtggt catactctca gcttgctgag tggatgacaa aaagagggga attgttaaag     1080

gaaaatttaa atggagactg gaaaaatcct gagcaaacaa aaccacctgg cccttagaaa     1140

tagctttaac tttgcttaaa ctacaaacac aagcaaaact tcacggggtc atactacata     1200

caagcataag caaaacttaa cttggatcat ttctggtaaa tgcttatgtt agaaataaga     1260

caaccccagc caatcacaag cagcctacta acatataatt aggtgactag ggactttcta     1320

agaagatacc tacccccaaa aaacaattat gtaattgaaa accaaccgat tgcctttatt     1380

ttgcttccac attttcccaa taaatacttg cctgtgacat tttgccactg gaacactaaa     1440

cttcatgaat tgcgcctcag atttttcctt taacatcttt tttttttttg acagagtctc     1500

aatctgttac ccaggctgga gtgcagtggt gctatcttgg ctcactgcaa acccgcctcc     1560

caggtttaag cgattctcat gcctcagcct cccagtagct gggattagag gcatgtgcca     1620

tcatacccag ctaatttttg tattttttat tttttttttt tagtagagac agggtttcgc     1680

aatgttggcc aggccgatct cgaacttctg gcctctagcg atctgcccgc ctcggcctcc     1740

caaagtgctg ggatgaccag catcagcccc aatgtccagc ctctttaaca tcttctttcc     1800

tatgccctct ctgtggatcc ctactgctgg tttctgcctt ctccatgctg agaacaaaat     1860

cacctattca ctgcttatgc agtcggaagc tccagaagaa caaagagccc aattaccaga     1920

accacattaa gtctccattg ttttgccttg ggatttgaga agagaattag agaggtgagg     1980

atctggtatt tcctggacta aattcccctt ggggaagacg aagggatgct gcagttccaa     2040

aagagaagga ctcttccaga gtcatctacc tgagtcccaa agctccctgt cctgaaagcc     2100

acagacaata tggtcccaaa tgactgactg caccttctgt gcctcagccg ttcttgacat     2160

caagaatctt ctgttccaca tccacacagc caatacaatt agtcaaacca ctgttattaa     2220

cagatgtagc aacatgagaa acgcttatgt tacaggttac atgagagcaa tcatgtaagt     2280

ctatatgact tcagaaatgt taaaatagac taacctctaa caacaaatta aaagtgattg     2340

tttcaaggtg atgcaattat tgatgaccta ttttattttt ctataatgat catatattac     2400

ctttgtaata aaacattata accaaaaca                                       2429


<210>  62
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Thr Met Glu Thr Gln Met Ser Gln Asn Val Cys Pro Arg Asn Leu 
1               5                   10                  15      


Trp Leu Leu Gln Pro Leu Thr Val Leu Leu Leu Leu Ala Ser Ala Asp 
            20                  25                  30          


Ser Gln Ala Ala Ala Pro Pro Lys Ala Val Leu Lys Leu Glu Pro Pro 
        35                  40                  45              


Trp Ile Asn Val Leu Gln Glu Asp Ser Val Thr Leu Thr Cys Gln Gly 
    50                  55                  60                  


Ala Arg Ser Pro Glu Ser Asp Ser Ile Gln Trp Phe His Asn Gly Asn 
65                  70                  75                  80  


Leu Ile Pro Thr His Thr Gln Pro Ser Tyr Arg Phe Lys Ala Asn Asn 
                85                  90                  95      


Asn Asp Ser Gly Glu Tyr Thr Cys Gln Thr Gly Gln Thr Ser Leu Ser 
            100                 105                 110         


Asp Pro Val His Leu Thr Val Leu Ser Glu Trp Leu Val Leu Gln Thr 
        115                 120                 125             


Pro His Leu Glu Phe Gln Glu Gly Glu Thr Ile Met Leu Arg Cys His 
    130                 135                 140                 


Ser Trp Lys Asp Lys Pro Leu Val Lys Val Thr Phe Phe Gln Asn Gly 
145                 150                 155                 160 


Lys Ser Gln Lys Phe Ser His Leu Asp Pro Thr Phe Ser Ile Pro Gln 
                165                 170                 175     


Ala Asn His Ser His Ser Gly Asp Tyr His Cys Thr Gly Asn Ile Gly 
            180                 185                 190         


Tyr Thr Leu Phe Ser Ser Lys Pro Val Thr Ile Thr Val Gln Val Pro 
        195                 200                 205             


Ser Met Gly Ser Ser Ser Pro Met Gly Ile Ile Val Ala Val Val Ile 
    210                 215                 220                 


Ala Thr Ala Val Ala Ala Ile Val Ala Ala Val Val Ala Leu Ile Tyr 
225                 230                 235                 240 


Cys Arg Lys Lys Arg Ile Ser Ala Asn Ser Thr Asp Pro Val Lys Ala 
                245                 250                 255     


Ala Gln Phe Glu Pro Pro Gly Arg Gln Met Ile Ala Ile Arg Lys Arg 
            260                 265                 270         


Gln Leu Glu Glu Thr Asn Asn Asp Tyr Glu Thr Ala Asp Gly Gly Tyr 
        275                 280                 285             


Met Thr Leu Asn Pro Arg Ala Pro Thr Asp Asp Asp Lys Asn Ile Tyr 
    290                 295                 300                 


Leu Thr Leu Pro Pro Asn Asp His Val Asn Ser Asn Asn 
305                 310                 315         


<210>  63
<211>  1193
<212>  DNA
<213>  Homo sapiens

<400>  63
cgctccacct ctcaagcagc cagcgcctgc ctgaatctgt tctgccccct ccccacccat       60

ttcaccacca ccatgacacc gggcacccag tctcctttct tcctgctgct gctcctcaca      120

gtgcttacag ctaccacagc ccctaaaccc gcaacagttg ttacgggttc tggtcatgca      180

agctctaccc caggtggaga aaaggagact tcggctaccc agagaagttc agtgcccagc      240

tctactgaga agaatgcttt taattcctct ctggaagatc ccagcaccga ctactaccaa      300

gagctgcaga gagacatttc tgaaatgttt ttgcagattt ataaacaagg gggttttctg      360

ggcctctcca atattaagtt caggccagga tctgtggtgg tacaattgac tctggccttc      420

cgagaaggta ccatcaatgt ccacgacgtg gagacacagt tcaatcagta taaaacggaa      480

gcagcctctc gatataacct gacgatctca gacgtcagcg tgagtgatgt gccatttcct      540

ttctctgccc agtctggggc tggggtgcca ggctggggca tcgcgctgct ggtgctggtc      600

tgtgttctgg ttgcgctggc cattgtctat ctcattgcct tggctgtctg tcagtgccgc      660

cgaaagaact acgggcagct ggacatcttt ccagcccggg atacctacca tcctatgagc      720

gagtacccca cctaccacac ccatgggcgc tatgtgcccc ctagcagtac cgatcgtagc      780

ccctatgaga aggtttctgc aggtaatggt ggcagcagcc tctcttacac aaacccagca      840

gtggcagcca cttctgccaa cttgtagggg cacgtcgccc gctgagctga gtggccagcc      900

agtgccattc cactccactc aggttcttca gggccagagc ccctgcaccc tgtttgggct      960

ggtgagctgg gagttcaggt gggctgctca cagcctcctt cagaggcccc accaatttct     1020

cggacacttc tcagtgtgtg gaagctcatg tgggcccctg agggctcatg cctgggaagt     1080

gttgtggtgg gggctcccag gaggactggc ccagagagcc ctgagatagc ggggatcctg     1140

aactggactg aataaaacgt ggtctcccac tgcgccaaaa aaaaaaaaaa aaa            1193


<210>  64
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn 
    50                  55                  60                  


Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg 
65                  70                  75                  80  


Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu 
                85                  90                  95      


Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu 
            100                 105                 110         


Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr 
        115                 120                 125             


Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr 
    130                 135                 140                 


Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln 
145                 150                 155                 160 


Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val 
                165                 170                 175     


Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val 
            180                 185                 190         


Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala 
        195                 200                 205             


Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His 
    210                 215                 220                 


Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys 
225                 230                 235                 240 


Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala 
                245                 250                 255     


Val Ala Ala Thr Ser Ala Asn Leu 
            260                 


<210>  65
<211>  1629
<212>  DNA
<213>  Homo sapiens

<400>  65
acacatcagg ggcttgctct tgcaaaacca aaccacaaga cagacttgca aaagaaggca       60

tgcacagctc agcactgctc tgttgcctgg tcctcctgac tggggtgagg gccagcccag      120

gccagggcac ccagtctgag aacagctgca cccacttccc aggcaacctg cctaacatgc      180

ttcgagatct ccgagatgcc ttcagcagag tgaagacttt ctttcaaatg aaggatcagc      240

tggacaactt gttgttaaag gagtccttgc tggaggactt taagggttac ctgggttgcc      300

aagccttgtc tgagatgatc cagttttacc tggaggaggt gatgccccaa gctgagaacc      360

aagacccaga catcaaggcg catgtgaact ccctggggga gaacctgaag accctcaggc      420

tgaggctacg gcgctgtcat cgatttcttc cctgtgaaaa caagagcaag gccgtggagc      480

aggtgaagaa tgcctttaat aagctccaag agaaaggcat ctacaaagcc atgagtgagt      540

ttgacatctt catcaactac atagaagcct acatgacaat gaagatacga aactgagaca      600

tcagggtggc gactctatag actctaggac ataaattaga ggtctccaaa atcggatctg      660

gggctctggg atagctgacc cagccccttg agaaacctta ttgtacctct cttatagaat      720

atttattacc tctgatacct caacccccat ttctatttat ttactgagct tctctgtgaa      780

cgatttagaa agaagcccaa tattataatt tttttcaata tttattattt tcacctgttt      840

ttaagctgtt tccatagggt gacacactat ggtatttgag tgttttaaga taaattataa      900

gttacataag ggaggaaaaa aaatgttctt tggggagcca acagaagctt ccattccaag      960

cctgaccacg ctttctagct gttgagctgt tttccctgac ctccctctaa tttatcttgt     1020

ctctgggctt ggggcttcct aactgctaca aatactctta ggaagagaaa ccagggagcc     1080

cctttgatga ttaattcacc ttccagtgtc tcggagggat tcccctaacc tcattcccca     1140

accacttcat tcttgaaagc tgtggccagc ttgttattta taacaaccta aatttggttc     1200

taggccgggc gcggtggctc acgcctgtaa tcccagcact ttgggaggct gaggcgggtg     1260

gatcacttga ggtcaggagt tcctaaccag cctggtcaac atggtgaaac cccgtctcta     1320

ctaaaaatac aaaaattagc cgggcatggt ggcgcgcacc tgtaatccca gctacttggg     1380

aggctgaggc aagagaattg cttgaaccca ggagatggaa gttgcagtga gctgatatca     1440

tgcccctgta ctccagcctg ggtgacagag caagactctg tctcaaaaaa taaaaataaa     1500

aataaatttg gttctaatag aactcagttt taactagaat ttattcaatt cctctgggaa     1560

tgttacattg tttgtctgtc ttcatagcag attttaattt tgaataaata aatgtatctt     1620

attcacatc                                                             1629


<210>  66
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  66

Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210>  67
<211>  4324
<212>  DNA
<213>  Homo sapiens

<400>  67
cggcggcggc gagagcagag gacgagccgg gacgcggcgc cgcggcacca gggcgcgcag       60

ccgggccggc ccgaccccac cggccatacg gtggagccat cgaagccccc acccacaggc      120

tgacagaggc accgttcacc agagggctca acaccgggat ctatgtttaa gttttaactc      180

tcgcctccaa agaccacgat aattccttcc ccaaagccca gcagcccccc agccccgcgc      240

agccccagcc tgcctcccgg cgcccagatg cccgccatgc cctccagcgg ccccggggac      300

accagcagct ctgctgcgga gcgggaggag gaccgaaagg acggagagga gcaggaggag      360

ccgcgtggca aggaggagcg ccaagagccc agcaccacgg cacggaaggt ggggcggcct      420

gggaggaagc gcaagcaccc cccggtggaa agcggtgaca cgccaaagga ccctgcggtg      480

atctccaagt ccccatccat ggcccaggac tcaggcgcct cagagctatt acccaatggg      540

gacttggaga agcggagtga gccccagcca gaggagggga gccctgctgg ggggcagaag      600

ggcggggccc cagcagaggg agagggtgca gctgagaccc tgcctgaagc ctcaagagca      660

gtggaaaatg gctgctgcac ccccaaggag ggccgaggag cccctgcaga agcgggcaaa      720

gaacagaagg agaccaacat cgaatccatg aaaatggagg gctcccgggg ccggctgcgg      780

ggtggcttgg gctgggagtc cagcctccgt cagcggccca tgccgaggct caccttccag      840

gcgggggacc cctactacat cagcaagcgc aagcgggacg agtggctggc acgctggaaa      900

agggaggctg agaagaaagc caaggtcatt gcaggaatga atgctgtgga agaaaaccag      960

gggcccgggg agtctcagaa ggtggaggag gccagccctc ctgctgtgca gcagcccact     1020

gaccccgcat cccccactgt ggctaccacg cctgagcccg tggggtccga tgctggggac     1080

aagaatgcca ccaaagcagg cgatgacgag ccagagtacg aggacggccg gggctttggc     1140

attggggagc tggtgtgggg gaaactgcgg ggcttctcct ggtggccagg ccgcattgtg     1200

tcttggtgga tgacgggccg gagccgagca gctgaaggca cccgctgggt catgtggttc     1260

ggagacggca aattctcagt ggtgtgtgtt gagaagctga tgccgctgag ctcgttttgc     1320

agtgcgttcc accaggccac gtacaacaag cagcccatgt accgcaaagc catctacgag     1380

gtcctgcagg tggccagcag ccgcgcgggg aagctgttcc cggtgtgcca cgacagcgat     1440

gagagtgaca ctgccaaggc cgtggaggtg cagaacaagc ccatgattga atgggccctg     1500

gggggcttcc agccttctgg ccctaagggc ctggagccac cagaagaaga gaagaatccc     1560

tacaaagaag tgtacacgga catgtgggtg gaacctgagg cagctgccta cgcaccacct     1620

ccaccagcca aaaagccccg gaagagcaca gcggagaagc ccaaggtcaa ggagattatt     1680

gatgagcgca caagagagcg gctggtgtac gaggtgcggc agaagtgccg gaacattgag     1740

gacatctgca tctcctgtgg gagcctcaat gttaccctgg aacaccccct cttcgttgga     1800

ggaatgtgcc aaaactgcaa gaactgcttt ctggagtgtg cgtaccagta cgacgacgac     1860

ggctaccagt cctactgcac catctgctgt gggggccgtg aggtgctcat gtgcggaaac     1920

aacaactgct gcaggtgctt ttgcgtggag tgtgtggacc tcttggtggg gccgggggct     1980

gcccaggcag ccattaagga agacccctgg aactgctaca tgtgcgggca caagggtacc     2040

tacgggctgc tgcggcggcg agaggactgg ccctcccggc tccagatgtt cttcgctaat     2100

aaccacgacc aggaatttga ccctccaaag gtttacccac ctgtcccagc tgagaagagg     2160

aagcccatcc gggtgctgtc tctctttgat ggaatcgcta cagggctcct ggtgctgaag     2220

gacttgggca ttcaggtgga ccgctacatt gcctcggagg tgtgtgagga ctccatcacg     2280

gtgggcatgg tgcggcacca ggggaagatc atgtacgtcg gggacgtccg cagcgtcaca     2340

cagaagcata tccaggagtg gggcccattc gatctggtga ttgggggcag tccctgcaat     2400

gacctctcca tcgtcaaccc tgctcgcaag ggcctctacg agggcactgg ccggctcttc     2460

tttgagttct accgcctcct gcatgatgcg cggcccaagg agggagatga tcgccccttc     2520

ttctggctct ttgagaatgt ggtggccatg ggcgttagtg acaagaggga catctcgcga     2580

tttctcgagt ccaaccctgt gatgattgat gccaaagaag tgtcagctgc acacagggcc     2640

cgctacttct ggggtaacct tcccggtatg aacaggccgt tggcatccac tgtgaatgat     2700

aagctggagc tgcaggagtg tctggagcat ggcaggatag ccaagttcag caaagtgagg     2760

accattacta cgaggtcaaa ctccataaag cagggcaaag accagcattt tcctgtcttc     2820

atgaatgaga aagaggacat cttatggtgc actgaaatgg aaagggtatt tggtttccca     2880

gtccactata ctgacgtctc caacatgagc cgcttggcga ggcagagact gctgggccgg     2940

tcatggagcg tgccagtcat ccgccacctc ttcgctccgc tgaaggagta ttttgcgtgt     3000

gtgtaaggga catgggggca aactgaggta gcgacacaaa gttaaacaaa caaacaaaaa     3060

acacaaaaca taataaaaca ccaagaacat gaggatggag agaagtatca gcacccagaa     3120

gagaaaaagg aatttaaaac aaaaaccaca gaggcggaaa taccggaggg ctttgccttg     3180

cgaaaagggt tggacatcat ctcctgattt ttcaatgtta ttcttcagtc ctatttaaaa     3240

acaaaaccaa gctcccttcc cttcctcccc cttccctttt ttttcggtca gaccttttat     3300

tttctactct tttcagaggg gttttctgtt tgtttgggtt ttgtttcttg ctgtgactga     3360

aacaagaagg ttattgcagc aaaaatcagt aacaaaaaat agtaacaata ccttgcagag     3420

gaaaggtggg agagaggaaa aaaggaaatt ctatagaaat ctatatattg ggttgttttt     3480

ttttttgttt tttgtttttt ttttttgggt tttttttttt actatatatc ttttttttgt     3540

tgtctctagc ctgatcagat aggagcacaa gcaggggacg gaaagagaga gacactcagg     3600

cggcagcatt ccctcccagc cactgagctg tcgtgccagc accattcctg gtcacgcaaa     3660

acagaaccca gttagcagca gggagacgag aacaccacac aagacatttt tctacagtat     3720

ttcaggtgcc taccacacag gaaaccttga agaaaatcag tttctagaag ccgctgttac     3780

ctcttgttta cagtttatat atatatgata gatatgagat atatatataa aaggtactgt     3840

taactactgt acaacccgac ttcataatgg tgctttcaaa cagcgagatg agtaaaaaca     3900

tcagcttcca cgttgccttc tgcgcaaagg gtttcaccaa ggatggagaa agggagacag     3960

cttgcagatg gcgcgttctc acggtgggct cttccccttg gtttgtaacg aagtgaagga     4020

ggagaacttg ggagccaggt tctccctgcc aaaaaggggg ctagatgagg tggtcgggcc     4080

cgtggacagc tgagagtggg attcatccag actcatgcaa taaccctttg attgttttct     4140

aaaaggagac tccctcggca agatggcaga gggtacggag tcttcaggcc cagtttctca     4200

ctttagccaa ttcgagggct ccttgtggtg ggatcagaac taatccagag tgtgggaaag     4260

tgacagtcaa aaccccacct ggagcaaata aaaaaacata caaaacgtac tggtgctttc     4320

ctgt                                                                  4324


<210>  68
<211>  912
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Pro Ala Met Pro Ser Ser Gly Pro Gly Asp Thr Ser Ser Ser Ala 
1               5                   10                  15      


Ala Glu Arg Glu Glu Asp Arg Lys Asp Gly Glu Glu Gln Glu Glu Pro 
            20                  25                  30          


Arg Gly Lys Glu Glu Arg Gln Glu Pro Ser Thr Thr Ala Arg Lys Val 
        35                  40                  45              


Gly Arg Pro Gly Arg Lys Arg Lys His Pro Pro Val Glu Ser Gly Asp 
    50                  55                  60                  


Thr Pro Lys Asp Pro Ala Val Ile Ser Lys Ser Pro Ser Met Ala Gln 
65                  70                  75                  80  


Asp Ser Gly Ala Ser Glu Leu Leu Pro Asn Gly Asp Leu Glu Lys Arg 
                85                  90                  95      


Ser Glu Pro Gln Pro Glu Glu Gly Ser Pro Ala Gly Gly Gln Lys Gly 
            100                 105                 110         


Gly Ala Pro Ala Glu Gly Glu Gly Ala Ala Glu Thr Leu Pro Glu Ala 
        115                 120                 125             


Ser Arg Ala Val Glu Asn Gly Cys Cys Thr Pro Lys Glu Gly Arg Gly 
    130                 135                 140                 


Ala Pro Ala Glu Ala Gly Lys Glu Gln Lys Glu Thr Asn Ile Glu Ser 
145                 150                 155                 160 


Met Lys Met Glu Gly Ser Arg Gly Arg Leu Arg Gly Gly Leu Gly Trp 
                165                 170                 175     


Glu Ser Ser Leu Arg Gln Arg Pro Met Pro Arg Leu Thr Phe Gln Ala 
            180                 185                 190         


Gly Asp Pro Tyr Tyr Ile Ser Lys Arg Lys Arg Asp Glu Trp Leu Ala 
        195                 200                 205             


Arg Trp Lys Arg Glu Ala Glu Lys Lys Ala Lys Val Ile Ala Gly Met 
    210                 215                 220                 


Asn Ala Val Glu Glu Asn Gln Gly Pro Gly Glu Ser Gln Lys Val Glu 
225                 230                 235                 240 


Glu Ala Ser Pro Pro Ala Val Gln Gln Pro Thr Asp Pro Ala Ser Pro 
                245                 250                 255     


Thr Val Ala Thr Thr Pro Glu Pro Val Gly Ser Asp Ala Gly Asp Lys 
            260                 265                 270         


Asn Ala Thr Lys Ala Gly Asp Asp Glu Pro Glu Tyr Glu Asp Gly Arg 
        275                 280                 285             


Gly Phe Gly Ile Gly Glu Leu Val Trp Gly Lys Leu Arg Gly Phe Ser 
    290                 295                 300                 


Trp Trp Pro Gly Arg Ile Val Ser Trp Trp Met Thr Gly Arg Ser Arg 
305                 310                 315                 320 


Ala Ala Glu Gly Thr Arg Trp Val Met Trp Phe Gly Asp Gly Lys Phe 
                325                 330                 335     


Ser Val Val Cys Val Glu Lys Leu Met Pro Leu Ser Ser Phe Cys Ser 
            340                 345                 350         


Ala Phe His Gln Ala Thr Tyr Asn Lys Gln Pro Met Tyr Arg Lys Ala 
        355                 360                 365             


Ile Tyr Glu Val Leu Gln Val Ala Ser Ser Arg Ala Gly Lys Leu Phe 
    370                 375                 380                 


Pro Val Cys His Asp Ser Asp Glu Ser Asp Thr Ala Lys Ala Val Glu 
385                 390                 395                 400 


Val Gln Asn Lys Pro Met Ile Glu Trp Ala Leu Gly Gly Phe Gln Pro 
                405                 410                 415     


Ser Gly Pro Lys Gly Leu Glu Pro Pro Glu Glu Glu Lys Asn Pro Tyr 
            420                 425                 430         


Lys Glu Val Tyr Thr Asp Met Trp Val Glu Pro Glu Ala Ala Ala Tyr 
        435                 440                 445             


Ala Pro Pro Pro Pro Ala Lys Lys Pro Arg Lys Ser Thr Ala Glu Lys 
    450                 455                 460                 


Pro Lys Val Lys Glu Ile Ile Asp Glu Arg Thr Arg Glu Arg Leu Val 
465                 470                 475                 480 


Tyr Glu Val Arg Gln Lys Cys Arg Asn Ile Glu Asp Ile Cys Ile Ser 
                485                 490                 495     


Cys Gly Ser Leu Asn Val Thr Leu Glu His Pro Leu Phe Val Gly Gly 
            500                 505                 510         


Met Cys Gln Asn Cys Lys Asn Cys Phe Leu Glu Cys Ala Tyr Gln Tyr 
        515                 520                 525             


Asp Asp Asp Gly Tyr Gln Ser Tyr Cys Thr Ile Cys Cys Gly Gly Arg 
    530                 535                 540                 


Glu Val Leu Met Cys Gly Asn Asn Asn Cys Cys Arg Cys Phe Cys Val 
545                 550                 555                 560 


Glu Cys Val Asp Leu Leu Val Gly Pro Gly Ala Ala Gln Ala Ala Ile 
                565                 570                 575     


Lys Glu Asp Pro Trp Asn Cys Tyr Met Cys Gly His Lys Gly Thr Tyr 
            580                 585                 590         


Gly Leu Leu Arg Arg Arg Glu Asp Trp Pro Ser Arg Leu Gln Met Phe 
        595                 600                 605             


Phe Ala Asn Asn His Asp Gln Glu Phe Asp Pro Pro Lys Val Tyr Pro 
    610                 615                 620                 


Pro Val Pro Ala Glu Lys Arg Lys Pro Ile Arg Val Leu Ser Leu Phe 
625                 630                 635                 640 


Asp Gly Ile Ala Thr Gly Leu Leu Val Leu Lys Asp Leu Gly Ile Gln 
                645                 650                 655     


Val Asp Arg Tyr Ile Ala Ser Glu Val Cys Glu Asp Ser Ile Thr Val 
            660                 665                 670         


Gly Met Val Arg His Gln Gly Lys Ile Met Tyr Val Gly Asp Val Arg 
        675                 680                 685             


Ser Val Thr Gln Lys His Ile Gln Glu Trp Gly Pro Phe Asp Leu Val 
    690                 695                 700                 


Ile Gly Gly Ser Pro Cys Asn Asp Leu Ser Ile Val Asn Pro Ala Arg 
705                 710                 715                 720 


Lys Gly Leu Tyr Glu Gly Thr Gly Arg Leu Phe Phe Glu Phe Tyr Arg 
                725                 730                 735     


Leu Leu His Asp Ala Arg Pro Lys Glu Gly Asp Asp Arg Pro Phe Phe 
            740                 745                 750         


Trp Leu Phe Glu Asn Val Val Ala Met Gly Val Ser Asp Lys Arg Asp 
        755                 760                 765             


Ile Ser Arg Phe Leu Glu Ser Asn Pro Val Met Ile Asp Ala Lys Glu 
    770                 775                 780                 


Val Ser Ala Ala His Arg Ala Arg Tyr Phe Trp Gly Asn Leu Pro Gly 
785                 790                 795                 800 


Met Asn Arg Pro Leu Ala Ser Thr Val Asn Asp Lys Leu Glu Leu Gln 
                805                 810                 815     


Glu Cys Leu Glu His Gly Arg Ile Ala Lys Phe Ser Lys Val Arg Thr 
            820                 825                 830         


Ile Thr Thr Arg Ser Asn Ser Ile Lys Gln Gly Lys Asp Gln His Phe 
        835                 840                 845             


Pro Val Phe Met Asn Glu Lys Glu Asp Ile Leu Trp Cys Thr Glu Met 
    850                 855                 860                 


Glu Arg Val Phe Gly Phe Pro Val His Tyr Thr Asp Val Ser Asn Met 
865                 870                 875                 880 


Ser Arg Leu Ala Arg Gln Arg Leu Leu Gly Arg Ser Trp Ser Val Pro 
                885                 890                 895     


Val Ile Arg His Leu Phe Ala Pro Leu Lys Glu Tyr Phe Ala Cys Val 
            900                 905                 910         


<210>  69
<211>  8789
<212>  DNA
<213>  Homo sapiens

<400>  69
atgctcagtg gcttctcgac aagttggcag caacaacacg gccctggtcg tcgtcgccgc       60

tgcggtaacg gagcggtttg ggtggcggag cctgcgttcg cgccttcccg ctctcctcgg      120

gaggcccttc ctgctctccc ctaggctccg cggccgccca gggggtggga gcgggtgagg      180

ggagccaggc gcccagcgag agaggccccc cgccgcaggg cggcccggga gctcgaggcg      240

gtccggcccg cgcgggcagc ggcgcggcgc tgaggagggg cggcctggcc gggacgcctc      300

ggggcggggg ccgaggagct ctccgggccg ccggggaaag ctacgggccc ggtgcgtccg      360

cggaccagca gcgcgggaga gcggactccc ctcgccaccg cccgagccca ggttatcctg      420

aatacatgtc taacaatttt ccttgcaacg ttagctgttg tttttcactg tttccaaagg      480

atcaaaattg cttcagaaat tggagacata tttgatttaa aaggaaaaac ttgaacaaat      540

ggacaatatg tctattacga atacaccaac aagtaatgat gcctgtctga gcattgtgca      600

tagtttgatg tgccatagac aaggtggaga gagtgaaaca tttgcaaaaa gagcaattga      660

aagtttggta aagaagctga aggagaaaaa agatgaattg gattctttaa taacagctat      720

aactacaaat ggagctcatc ctagtaaatg tgttaccata cagagaacat tggatgggag      780

gcttcaggtg gctggtcgga aaggatttcc tcatgtgatc tatgcccgtc tctggaggtg      840

gcctgatctt cacaaaaatg aactaaaaca tgttaaatat tgtcagtatg cgtttgactt      900

aaaatgtgat agtgtctgtg tgaatccata tcactacgaa cgagttgtat cacctggaat      960

tgatctctca ggattaacac tgcagagtaa tgctccatca agtatgatgg tgaaggatga     1020

atatgtgcat gactttgagg gacagccatc gttgtccact gaaggacatt caattcaaac     1080

catccagcat ccaccaagta atcgtgcatc gacagagaca tacagcaccc cagctctgtt     1140

agccccatct gagtctaatg ctaccagcac tgccaacttt cccaacattc ctgtggcttc     1200

cacaagtcag cctgccagta tactgggggg cagccatagt gaaggactgt tgcagatagc     1260

atcagggcct cagccaggac agcagcagaa tggatttact ggtcagccag ctacttacca     1320

tcataacagc actaccacct ggactggaag taggactgca ccatacacac ctaatttgcc     1380

tcaccaccaa aacggccatc ttcagcacca cccgcctatg ccgccccatc ccggacatta     1440

ctggcctgtt cacaatgagc ttgcattcca gcctcccatt tccaatcatc ctgctcctga     1500

gtattggtgt tccattgctt actttgaaat ggatgttcag gtaggagaga catttaaggt     1560

tccttcaagc tgccctattg ttactgttga tggatacgtg gacccttctg gaggagatcg     1620

cttttgtttg ggtcaactct ccaatgtcca caggacagaa gccattgaga gagcaaggtt     1680

gcacataggc aaaggtgtgc agttggaatg taaaggtgaa ggtgatgttt gggtcaggtg     1740

ccttagtgac cacgcggtct ttgtacagag ttactactta gacagagaag ctgggcgtgc     1800

acctggagat gctgttcata agatctaccc aagtgcatat ataaaggtct ttgatttgcg     1860

tcagtgtcat cgacagatgc agcagcaggc ggctactgca caagctgcag cagctgccca     1920

ggcagcagcc gtggcaggaa acatccctgg cccaggatca gtaggtggaa tagctccagc     1980

tatcagtctg tcagctgctg ctggaattgg tgttgatgac cttcgtcgct tatgcatact     2040

caggatgagt tttgtgaaag gctggggacc ggattaccca agacagagca tcaaagaaac     2100

accttgctgg attgaaattc acttacaccg ggccctccag ctcctagacg aagtacttca     2160

taccatgccg attgcagacc cacaaccttt agactgaggt cttttaccgt tggggccctt     2220

aaccttatca ggatggtgga ctacaaaata caatcctgtt tataatctga agatatattt     2280

cacttttgtt ctgctttatc ttttcataaa gggttgaaaa tgtgtttgct gccttgctcc     2340

tagcagacag aaactggatt aaaacaattt tttttttcct cttcagaact tgtcaggcat     2400

ggctcagagc ttgaagatta ggagaaacac attcttatta attcttcacc tgttatgtat     2460

gaaggaatca ttccagtgct agaaaattta gccctttaaa acgtcttaga gccttttatc     2520

tgcagaacat cgatatgtat atcattctac agaataatcc agtattgctg attttaaagg     2580

cagagaagtt ctcaaagtta attcacctat gttattttgt gtacaagttg ttattgttga     2640

acatacttca aaaataatgt gccatgtggg tgagttaatt ttaccaagag taactttact     2700

ctgtgtttaa aaagtaagtt aataatgtat tgtaatcttt catccaaaat attttttgca     2760

agttatatta gtgaagatgg tttcaattca gattgtcttg caacttcagt tttatttttg     2820

ccaaggcaaa aaactcttaa tctgtgtgta tattgagaat cccttaaaat taccagacaa     2880

aaaaatttaa aattacgttt gttattccta gtggatgact gttgatgaag tatacttttc     2940

ccctgttaaa cagtagttgt attcttctgt atttctaggc acaaggttgg ttgctaagaa     3000

gcctataaga ggaatttctt ttccttcatt catagggaaa ggttttgtat tttttaaaac     3060

actaaaagca gcgtcactct acctaatgtc tcactgttct gcaaaggtgg caatgcttaa     3120

actaaataat gaataaactg aatattttgg aaactgctaa attctatgtt aaatactgtg     3180

cagaataatg gaaacattac agttcataat aggtagtttg gatatttttg tacttgattt     3240

gatgtgactt tttttggtat aatgtttaaa tcatgtatgt tatgatattg tttaaaattc     3300

agtttttgta tcttggggca agactgcaaa cttttttata tcttttggtt attctaagcc     3360

ctttgccatc aatgatcata tcaattggca gtgactttgt atagagaatt taagtagaaa     3420

agttgcagat gtattgactg taccacagac acaatatgta tgctttttac ctagctggta     3480

gcataaataa aactgaatct caacatacaa agttgaattc taggtttgat ttttaagatt     3540

ttttttttct tttgcacttt tgagtccaat ctcagtgatg aggtaccttc tactaaatga     3600

caggcaacag ccagttctat tgggcagctt tgtttttttc cctcacactc taccgggact     3660

tccccatgga cattgtgtat catgtgtaga gttggttttt ttttttttta atttttattt     3720

tactatagca gaaatagacc tgattatcta caagatgata aatagattgt ctacaggata     3780

aatagtatga aataaaatca aggattatct ttcagatgtg tttacttttg cctggagaac     3840

ttttagctat agaaacactt gtgtgatgat agtcctcctt atatcacctg gaatgaacac     3900

agcttctact gccttgctca gaaggtcttt taaatagacc atcctagaaa ccactgagtt     3960

tgcttatttc tgtgatttaa acatagatct tgatccaagc tacatgactt ttgtctttaa     4020

ataacttatc taccacctca tttgtactct tgattactta caaattcttt cagtaaacac     4080

ctaattttct tctgtaaaag tttggtgatt taagttttat tggcagtttt ataaaaagac     4140

atcttctcta gaaattgcta actttaggtc cattttactg tgaatgagga ataggagtga     4200

gttttagaat aacagatttt taaaaatcca gatgatttga ttaaaacctt aatcatacat     4260

tgacataatt cattgcttct tttttttgag atatggagtc ttgctgtgtt gcccaggcag     4320

gagtgcagtg gtatgatctc agctcactgc aacctctgcc tcccgggttc aactgattct     4380

cctgcctcag cctccctggt agctaggatt acaggtgccc gccaccatgc ctggctaact     4440

tttgtagttt tagtagagac ggggttttgc ctgttggcca ggctggtctt gaactcctga     4500

cctcaagtga tccatccacc ttggcctccc aaagtgctgg gattacgggc gtgagccact     4560

gtccctggcc tcattgttcc cttttctact ttaaggaaag ttttcatgtt taatcatctg     4620

gggaaagtat gtgaaaaata tttgttaaga agtatctctt tggagccaag ccacctgtct     4680

tggtttcttt ctactaagag ccataaagta tagaaatact tctagttgtt aagtgcttat     4740

atttgtacct agatttagtc acacgctttt gagaaaacat ctagtatgtt atgatcagct     4800

attcctgaga gcttggttgt taatctatat ttctatttct tagtggtagt catctttgat     4860

gaataagact aaagattctc acaggtttaa aattttatgt ctactttaag ggtaaaatta     4920

tgaggttatg gttctgggtg ggttttctct agctaattca tatctcaaag agtctcaaaa     4980

tgttgaattt cagtgcaagc tgaatgagag atgagccatg tacacccacc gtaagacctc     5040

attccatgtt tgtccagtgc ctttcagtgc attatcaaag ggaatccttc atggtgttgc     5100

ctttattttc cggggagtag atcgtgggat atagtctatc tcatttttaa tagtttaccg     5160

cccctggtat acaaagataa tgacaataaa tcactgccat ataaccttgc tttttccaga     5220

aacatggctg ttttgtattg ctgtaaccac taaataggtt gcctatacca ttcctcctgt     5280

gaacagtgca gatttacagg ttgcatggtc tggcttaagg agagccatac ttgagacatg     5340

tgagtaaact gaactcatat tagctgtgct gcatttcaga cttaaaatcc atttttgtgg     5400

ggcagggtgt ggtgtgtaaa ggggggtgtt tgtaatacaa gttgaaggca aaataaaatg     5460

tcctgtctcc cagatgatat acatcttatt atttttaaag tttattgcta attgtaggaa     5520

ggtgagttgc aggtatcttt gactatggtc atctggggaa ggaaaatttt acattttact     5580

attaatgctc cttaagtgtc tatggaggtt aaagaataaa atggtaaatg tttctgtgcc     5640

tggtttgatg gtaactggtt aatagttact caccatttta tgcagagtca cattagttca     5700

caccctttct gagagccttt tgggagaagc agttttattc tctgagtgga acagagttct     5760

ttttgttgat aatttctagt ttgctccctt cgttattgcc aactttactg gcattttatt     5820

taatgatagc agattgggaa aatggcaaat ttaggttacg gaggtaaatg agtatatgaa     5880

agcaattacc tctaaagcca gttaacaatt attttgtagg tggggtacac tcagcttaaa     5940

gtaatgcatt tttttttccc gtaaaggcag aatccatctt gttgcagata gctatctaaa     6000

taatctcata tcctcttttg caaagactac agagaatagg ctatgacaat cttgttcaag     6060

cctttccatt tttttccctg ataactaagt aatttctttg aacataccaa gaagtatgta     6120

aaaagtccat ggccttattc atccacaaag tggcatccta ggcccagcct tatccctagc     6180

agttgtccca gtgctgctag gttgcttatc ttgtttatct ggaatcactg tggagtgaaa     6240

ttttccacat catccagaat tgccttattt aagaagtaaa acgttttaat ttttagcctt     6300

tttttggtgg agttatttaa tatgtatatc agaggatata ctagatggta acatttcttt     6360

ctgtgcttgg ctatctttgt ggacttcagg ggcttctaaa acagacagga ctgtgttgcc     6420

tttactaaat ggtctgagac agctatggtt ttgaattttt agtttttttt ttttaaccca     6480

cttcccctcc tggtctcttc cctctctgat aattaccatt catatgtgag tgttagtgtg     6540

cctcctttta gcattttctt cttctctttc tgattcttca tttctgactg cctaggcaag     6600

gaaaccagat aaccaaactt actagaacgt tctttaaaac acaagtacaa actctgggac     6660

aggacccaag acactttcct gtgaagtgct gaaaaagacc tcattgtatt ggcatttgat     6720

atcagtttga tgtagcttag agtgcttcct gattcttgct gagtttcagg tagttgagat     6780

agagagaagt gagtcatatt catattttcc cccttagaat aatattttga aaggtttcat     6840

tgcttccact tgaatgctgc tcttacaaaa actggggtta caagggttac taaattagca     6900

tcagtagcca gaggcaatac cgttgtctgg aggacaccag caaacaacac acaacaaagc     6960

aaaacaaacc ttgggaaact aaggccattt gttttgtttt ggtgtcccct ttgaagccct     7020

gccttctggc cttactcctg tacagatatt tttgacctat aggtgccttt atgagaattg     7080

agggtctgac atcctgcccc aaggagtagc taaagtaatt gctagtgttt tcagggattt     7140

taacatcaga ctggaatgaa tgaatgaaac tttttgtcct ttttttttct gttttttttt     7200

ttctaatgta gtaaggacta aggaaaacct ttggtgaaga caatcatttc tctctgttga     7260

tgtggatact tttcacaccg tttatttaaa tgctttctca ataggtccag agccagtgtt     7320

cttgttcaac ctgaaagtaa tggctctggg ttgggccaga cagttgcact ctctagtttg     7380

ccctctgcca caaatttgat gtgtgacctt tgggcaagtc atttatcttc tctgggcctt     7440

agttgcctca tctgtaaaat gagggagttg gagtagatta attattccag ctctgaaatt     7500

ctaagtgacc ttggctacct tgcagcagtt ttggatttct tccttatctt tgttctgctg     7560

tttgaggggg ctttttactt atttccatgt tattcaaagg agactaggct tgatatttta     7620

ttactgttct tttatggaca aaaggttaca tagtatgccc ttaagactta attttaacca     7680

aaggcctagc accaccttag gggctgcaat aaacacttaa cgcgcgtgcg cacgcgcgcg     7740

cgcacacaca cacacacaca cacacacaca cacaggtcag agtttaaggc tttcgagtca     7800

tgacattcta gcttttgaat tgcgtgcaca cacacacgca cgcacacact ctggtcagag     7860

tttattaagg ctttcgagtc atgacattat agcttttgag ttggtgtgtg tgacaccacc     7920

ctcctaagtg gtgtgtgctt gtaatttttt ttttcagtga aaatggattg aaaacctgtt     7980

gttaatgctt agtgatatta tgctcaaaac aaggaaattc ccttgaaccg tgtcaattaa     8040

actggtttat atgactcaag aaaacaatac cagtagatga ttattaactt tattcttggc     8100

tctttttagg tccattttga ttaagtgact tttggctgga tcattcagag ctctcttcta     8160

gcctaccctt ggatgagtac aattaatgaa attcatattt tcaaggacct gggagccttc     8220

cttggggctg ggttgagggt ggggggttgg ggagtcctgg tagaggccag ctttgtggta     8280

gctggagagg aagggatgaa accagctgct gttgcaaagg ctgcttgtca ttgatagaag     8340

gactcacggg cttggattga ttaagactaa acatggagtt ggcaaacttt cttcaagtat     8400

tgagttctgt tcaatgcatt ggacatgtga tttaagggaa aagtgtgaat gcttatagat     8460

gatgaaaacc tggtgggctg cagagcccag tttagaagaa gtgagttggg ggttggggac     8520

agatttggtg gtggtatttc ccaactgttt cctcccctaa attcagagga atgcagctat     8580

gccagaagcc agagaagagc cactcgtagc ttctgctttg gggacaactg gtcagttgaa     8640

agtcccagga gttcctttgt ggctttctgt atacttttgc ctggttaaag tctgtggcta     8700

aaaaatagtc gaacctttct tgagaactct gtaacaaagt atgtttttga ttaaaagaga     8760

aagccaacta aaaaaaaaaa aaaaaaaaa                                       8789


<210>  70
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Asp Asn Met Ser Ile Thr Asn Thr Pro Thr Ser Asn Asp Ala Cys 
1               5                   10                  15      


Leu Ser Ile Val His Ser Leu Met Cys His Arg Gln Gly Gly Glu Ser 
            20                  25                  30          


Glu Thr Phe Ala Lys Arg Ala Ile Glu Ser Leu Val Lys Lys Leu Lys 
        35                  40                  45              


Glu Lys Lys Asp Glu Leu Asp Ser Leu Ile Thr Ala Ile Thr Thr Asn 
    50                  55                  60                  


Gly Ala His Pro Ser Lys Cys Val Thr Ile Gln Arg Thr Leu Asp Gly 
65                  70                  75                  80  


Arg Leu Gln Val Ala Gly Arg Lys Gly Phe Pro His Val Ile Tyr Ala 
                85                  90                  95      


Arg Leu Trp Arg Trp Pro Asp Leu His Lys Asn Glu Leu Lys His Val 
            100                 105                 110         


Lys Tyr Cys Gln Tyr Ala Phe Asp Leu Lys Cys Asp Ser Val Cys Val 
        115                 120                 125             


Asn Pro Tyr His Tyr Glu Arg Val Val Ser Pro Gly Ile Asp Leu Ser 
    130                 135                 140                 


Gly Leu Thr Leu Gln Ser Asn Ala Pro Ser Ser Met Met Val Lys Asp 
145                 150                 155                 160 


Glu Tyr Val His Asp Phe Glu Gly Gln Pro Ser Leu Ser Thr Glu Gly 
                165                 170                 175     


His Ser Ile Gln Thr Ile Gln His Pro Pro Ser Asn Arg Ala Ser Thr 
            180                 185                 190         


Glu Thr Tyr Ser Thr Pro Ala Leu Leu Ala Pro Ser Glu Ser Asn Ala 
        195                 200                 205             


Thr Ser Thr Ala Asn Phe Pro Asn Ile Pro Val Ala Ser Thr Ser Gln 
    210                 215                 220                 


Pro Ala Ser Ile Leu Gly Gly Ser His Ser Glu Gly Leu Leu Gln Ile 
225                 230                 235                 240 


Ala Ser Gly Pro Gln Pro Gly Gln Gln Gln Asn Gly Phe Thr Gly Gln 
                245                 250                 255     


Pro Ala Thr Tyr His His Asn Ser Thr Thr Thr Trp Thr Gly Ser Arg 
            260                 265                 270         


Thr Ala Pro Tyr Thr Pro Asn Leu Pro His His Gln Asn Gly His Leu 
        275                 280                 285             


Gln His His Pro Pro Met Pro Pro His Pro Gly His Tyr Trp Pro Val 
    290                 295                 300                 


His Asn Glu Leu Ala Phe Gln Pro Pro Ile Ser Asn His Pro Ala Pro 
305                 310                 315                 320 


Glu Tyr Trp Cys Ser Ile Ala Tyr Phe Glu Met Asp Val Gln Val Gly 
                325                 330                 335     


Glu Thr Phe Lys Val Pro Ser Ser Cys Pro Ile Val Thr Val Asp Gly 
            340                 345                 350         


Tyr Val Asp Pro Ser Gly Gly Asp Arg Phe Cys Leu Gly Gln Leu Ser 
        355                 360                 365             


Asn Val His Arg Thr Glu Ala Ile Glu Arg Ala Arg Leu His Ile Gly 
    370                 375                 380                 


Lys Gly Val Gln Leu Glu Cys Lys Gly Glu Gly Asp Val Trp Val Arg 
385                 390                 395                 400 


Cys Leu Ser Asp His Ala Val Phe Val Gln Ser Tyr Tyr Leu Asp Arg 
                405                 410                 415     


Glu Ala Gly Arg Ala Pro Gly Asp Ala Val His Lys Ile Tyr Pro Ser 
            420                 425                 430         


Ala Tyr Ile Lys Val Phe Asp Leu Arg Gln Cys His Arg Gln Met Gln 
        435                 440                 445             


Gln Gln Ala Ala Thr Ala Gln Ala Ala Ala Ala Ala Gln Ala Ala Ala 
    450                 455                 460                 


Val Ala Gly Asn Ile Pro Gly Pro Gly Ser Val Gly Gly Ile Ala Pro 
465                 470                 475                 480 


Ala Ile Ser Leu Ser Ala Ala Ala Gly Ile Gly Val Asp Asp Leu Arg 
                485                 490                 495     


Arg Leu Cys Ile Leu Arg Met Ser Phe Val Lys Gly Trp Gly Pro Asp 
            500                 505                 510         


Tyr Pro Arg Gln Ser Ile Lys Glu Thr Pro Cys Trp Ile Glu Ile His 
        515                 520                 525             


Leu His Arg Ala Leu Gln Leu Leu Asp Glu Val Leu His Thr Met Pro 
    530                 535                 540                 


Ile Ala Asp Pro Gln Pro Leu Asp 
545                 550         


<210>  71
<211>  5477
<212>  DNA
<213>  Homo sapiens

<400>  71
aaaaagagaa actgttggga gaggaatcgt atctccatat ttcttctttc agccccaatc       60

caagggttgt agctggaact ttccatcagt tcttcctttc tttttcctct ctaagccttt      120

gccttgctct gtcacagtga agtcagccag agcagggctg ttaaactctg tgaaatttgt      180

cataagggtg tcaggtattt cttactggct tccaaagaaa catagataaa gaaatctttc      240

ctgtggcttc ccttggcagg ctgcattcag aaggtctctc agttgaagaa agagcttgga      300

ggacaacagc acaacaggag agtaaaagat gccccagggc tgaggcctcc gctcaggcag      360

ccgcatctgg ggtcaatcat actcaccttg cccgggccat gctccagcaa aatcaagctg      420

ttttcttttg aaagttcaaa ctcatcaaga ttatgctgct cactcttatc attctgttgc      480

cagtagtttc aaaatttagt tttgttagtc tctcagcacc gcagcactgg agctgtcctg      540

aaggtactct cgcaggaaat gggaattcta cttgtgtggg tcctgcaccc ttcttaattt      600

tctcccatgg aaatagtatc tttaggattg acacagaagg aaccaattat gagcaattgg      660

tggtggatgc tggtgtctca gtgatcatgg attttcatta taatgagaaa agaatctatt      720

gggtggattt agaaagacaa cttttgcaaa gagtttttct gaatgggtca aggcaagaga      780

gagtatgtaa tatagagaaa aatgtttctg gaatggcaat aaattggata aatgaagaag      840

ttatttggtc aaatcaacag gaaggaatca ttacagtaac agatatgaaa ggaaataatt      900

cccacattct tttaagtgct ttaaaatatc ctgcaaatgt agcagttgat ccagtagaaa      960

ggtttatatt ttggtcttca gaggtggctg gaagccttta tagagcagat ctcgatggtg     1020

tgggagtgaa ggctctgttg gagacatcag agaaaataac agctgtgtca ttggatgtgc     1080

ttgataagcg gctgttttgg attcagtaca acagagaagg aagcaattct cttatttgct     1140

cctgtgatta tgatggaggt tctgtccaca ttagtaaaca tccaacacag cataatttgt     1200

ttgcaatgtc cctttttggt gaccgtatct tctattcaac atggaaaatg aagacaattt     1260

ggatagccaa caaacacact ggaaaggaca tggttagaat taacctccat tcatcatttg     1320

taccacttgg tgaactgaaa gtagtgcatc cacttgcaca acccaaggca gaagatgaca     1380

cttgggagcc tgagcagaaa ctttgcaaat tgaggaaagg aaactgcagc agcactgtgt     1440

gtgggcaaga cctccagtca cacttgtgca tgtgtgcaga gggatacgcc ctaagtcgag     1500

accggaagta ctgtgaagat gttaatgaat gtgctttttg gaatcatggc tgtactcttg     1560

ggtgtaaaaa cacccctgga tcctattact gcacgtgccc tgtaggattt gttctgcttc     1620

ctgatgggaa acgatgtcat caacttgttt cctgtccacg caatgtgtct gaatgcagcc     1680

atgactgtgt tctgacatca gaaggtccct tatgtttctg tcctgaaggc tcagtgcttg     1740

agagagatgg gaaaacatgt agcggttgtt cctcacccga taatggtgga tgtagccagc     1800

tctgcgttcc tcttagccca gtatcctggg aatgtgattg ctttcctggg tatgacctac     1860

aactggatga aaaaagctgt gcagcttcag gaccacaacc atttttgctg tttgccaatt     1920

ctcaagatat tcgacacatg cattttgatg gaacagacta tggaactctg ctcagccagc     1980

agatgggaat ggtttatgcc ctagatcatg accctgtgga aaataagata tactttgccc     2040

atacagccct gaagtggata gagagagcta atatggatgg ttcccagcga gaaaggctta     2100

ttgaggaagg agtagatgtg ccagaaggtc ttgctgtgga ctggattggc cgtagattct     2160

attggacaga cagagggaaa tctctgattg gaaggagtga tttaaatggg aaacgttcca     2220

aaataatcac taaggagaac atctctcaac cacgaggaat tgctgttcat ccaatggcca     2280

agagattatt ctggactgat acagggatta atccacgaat tgaaagttct tccctccaag     2340

gccttggccg tctggttata gccagctctg atctaatctg gcccagtgga ataacgattg     2400

acttcttaac tgacaagttg tactggtgcg atgccaagca gtctgtgatt gaaatggcca     2460

atctggatgg ttcaaaacgc cgaagactta cccagaatga tgtaggtcac ccatttgctg     2520

tagcagtgtt tgaggattat gtgtggttct cagattgggc tatgccatca gtaatgagag     2580

taaacaagag gactggcaaa gatagagtac gtctccaagg cagcatgctg aagccctcat     2640

cactggttgt ggttcatcca ttggcaaaac caggagcaga tccctgctta tatcaaaacg     2700

gaggctgtga acatatttgc aaaaagaggc ttggaactgc ttggtgttcg tgtcgtgaag     2760

gttttatgaa agcctcagat gggaaaacgt gtctggctct ggatggtcat cagctgttgg     2820

caggtggtga agttgatcta aagaaccaag taacaccatt ggacatcttg tccaagacta     2880

gagtgtcaga agataacatt acagaatctc aacacatgct agtggctgaa atcatggtgt     2940

cagatcaaga tgactgtgct cctgtgggat gcagcatgta tgctcggtgt atttcagagg     3000

gagaggatgc cacatgtcag tgtttgaaag gatttgctgg ggatggaaaa ctatgttctg     3060

atatagatga atgtgagatg ggtgtcccag tgtgcccccc tgcctcctcc aagtgcatca     3120

acaccgaagg tggttatgtc tgccggtgct cagaaggcta ccaaggagat gggattcact     3180

gtcttgactc tactccaccc cctcacctca gggaagatga ccaccactat tccgtaagaa     3240

atagtgactc tgaatgtccc ctgtcccacg atgggtactg cctccatgat ggtgtgtgca     3300

tgtatattga agcattggac aagtatgcat gcaactgtgt tgttggctac atcggggagc     3360

gatgtcagta ccgagacctg aagtggtggg aactgcgcca cgctggccac gggcagcagc     3420

agaaggtcat cgtggtggct gtctgcgtgg tggtgcttgt catgctgctc ctcctgagcc     3480

tgtggggggc ccactactac aggactcaga agctgctatc gaaaaaccca aagaatcctt     3540

atgaggagtc gagcagagat gtgaggagtc gcaggcctgc tgacactgag gatgggatgt     3600

cctcttgccc tcaaccttgg tttgtggtta taaaagaaca ccaagacctc aagaatgggg     3660

gtcaaccagt ggctggtgag gatggccagg cagcagatgg gtcaatgcaa ccaacttcat     3720

ggaggcagga gccccagtta tgtggaatgg gcacagagca aggctgctgg attccagtat     3780

ccagtgataa gggctcctgt ccccaggtaa tggagcgaag ctttcatatg ccctcctatg     3840

ggacacagac ccttgaaggg ggtgtcgaga agccccattc tctcctatca gctaacccat     3900

tatggcaaca aagggccctg gacccaccac accaaatgga gctgactcag tgaaaactgg     3960

aattaaaagg aaagtcaaga agaatgaact atgtcgatgc acagtatctt ttctttcaaa     4020

agtagagcaa aactataggt tttggttcca caatctctac gactaatcac ctactcaatg     4080

cctggagaca gatacgtagt tgtgcttttg tttgctcttt taagcagtct cactgcagtc     4140

ttatttccaa gtaagagtac tgggagaatc actaggtaac ttattagaaa cccaaattgg     4200

gacaacagtg ctttgtaaat tgtgttgtct tcagcagtca atacaaatag atttttgttt     4260

ttgttgttcc tgcagcccca gaagaaatta ggggttaaag cagacagtca cactggtttg     4320

gtcagttaca aagtaatttc tttgatctgg acagaacatt tatatcagtt tcatgaaatg     4380

attggaatat tacaataccg ttaagataca gtgtaggcat ttaactcctc attggcgtgg     4440

tccatgctga tgattttgca aaatgagttg tgatgaatca atgaaaaatg taatttagaa     4500

actgatttct tcagaattag atggcttatt ttttaaaata tttgaatgaa aacattttat     4560

ttttaaaata ttacacagga ggcttcggag tttcttagtc attactgtcc ttttccccta     4620

cagaattttc cctcttggtg tgattgcaca gaatttgtat gtattttcag ttacaagatt     4680

gtaagtaaat tgcctgattt gttttcatta tagacaacga tgaatttctt ctaattattt     4740

aaataaaatc accaaaaaca taaacatttt attgtatgcc tgattaagta gttaattata     4800

gtctaaggca gtactagagt tgaaccaaaa tgatttgtca agcttgctga tgtttctgtt     4860

tttcgttttt tttttttttc cggagagagg ataggatctc actctgttat ccaggctgga     4920

gtgtgcaatg gcacaatcat agctcagtgc agcctcaaac tcctgggctc aagcaatcct     4980

cctgcctcag cctcccgagt aactaggacc acaggcacag gccaccatgc ctggctaagg     5040

tttttatttt tattttttgt agacatgggg atcacacaat gttgcccagg ctggtcttga     5100

actcctggcc tcaagcaagg tcgtgctggt aattttgcaa aatgaattgt gattgacttt     5160

cagcctccca acgtattaga ttataggcat tagccatggt gcccagcctt gtaactttta     5220

aaaaaatttt ttaatctaca actctgtaga ttaaaatttc acatggtgtt ctaattaaat     5280

atttttcttg cagccaagat attgttacta cagataacac aacctgatat ggtaacttta     5340

aattttgggg gctttgaatc attcagttta tgcattaact agtccctttg tttatctttc     5400

atttctcaac cccttgtact ttggtgatac cagacatcag aataaaaaga aattgaagta     5460

aaaaaaaaaa aaaaaaa                                                    5477


<210>  72
<211>  1166
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Leu Leu Thr Leu Ile Ile Leu Leu Pro Val Val Ser Lys Phe Ser 
1               5                   10                  15      


Phe Val Ser Leu Ser Ala Pro Gln His Trp Ser Cys Pro Glu Gly Thr 
            20                  25                  30          


Leu Ala Gly Asn Gly Asn Ser Thr Cys Val Gly Pro Ala Pro Phe Leu 
        35                  40                  45              


Ile Phe Ser His Gly Asn Ser Ile Phe Arg Ile Asp Thr Glu Gly Thr 
    50                  55                  60                  


Asn Tyr Glu Gln Leu Val Val Asp Ala Gly Val Ser Val Ile Met Asp 
65                  70                  75                  80  


Phe His Tyr Asn Glu Lys Arg Ile Tyr Trp Val Asp Leu Glu Arg Gln 
                85                  90                  95      


Leu Leu Gln Arg Val Phe Leu Asn Gly Ser Arg Gln Glu Arg Val Cys 
            100                 105                 110         


Asn Ile Glu Lys Asn Val Ser Gly Met Ala Ile Asn Trp Ile Asn Glu 
        115                 120                 125             


Glu Val Ile Trp Ser Asn Gln Gln Glu Gly Ile Ile Thr Val Thr Asp 
    130                 135                 140                 


Met Lys Gly Asn Asn Ser His Ile Leu Leu Ser Ala Leu Lys Tyr Pro 
145                 150                 155                 160 


Ala Asn Val Ala Val Asp Pro Val Glu Arg Phe Ile Phe Trp Ser Ser 
                165                 170                 175     


Glu Val Ala Gly Ser Leu Tyr Arg Ala Asp Leu Asp Gly Val Gly Val 
            180                 185                 190         


Lys Ala Leu Leu Glu Thr Ser Glu Lys Ile Thr Ala Val Ser Leu Asp 
        195                 200                 205             


Val Leu Asp Lys Arg Leu Phe Trp Ile Gln Tyr Asn Arg Glu Gly Ser 
    210                 215                 220                 


Asn Ser Leu Ile Cys Ser Cys Asp Tyr Asp Gly Gly Ser Val His Ile 
225                 230                 235                 240 


Ser Lys His Pro Thr Gln His Asn Leu Phe Ala Met Ser Leu Phe Gly 
                245                 250                 255     


Asp Arg Ile Phe Tyr Ser Thr Trp Lys Met Lys Thr Ile Trp Ile Ala 
            260                 265                 270         


Asn Lys His Thr Gly Lys Asp Met Val Arg Ile Asn Leu His Ser Ser 
        275                 280                 285             


Phe Val Pro Leu Gly Glu Leu Lys Val Val His Pro Leu Ala Gln Pro 
    290                 295                 300                 


Lys Ala Glu Asp Asp Thr Trp Glu Pro Glu Gln Lys Leu Cys Lys Leu 
305                 310                 315                 320 


Arg Lys Gly Asn Cys Ser Ser Thr Val Cys Gly Gln Asp Leu Gln Ser 
                325                 330                 335     


His Leu Cys Met Cys Ala Glu Gly Tyr Ala Leu Ser Arg Asp Arg Lys 
            340                 345                 350         


Tyr Cys Glu Asp Val Asn Glu Cys Ala Phe Trp Asn His Gly Cys Thr 
        355                 360                 365             


Leu Gly Cys Lys Asn Thr Pro Gly Ser Tyr Tyr Cys Thr Cys Pro Val 
    370                 375                 380                 


Gly Phe Val Leu Leu Pro Asp Gly Lys Arg Cys His Gln Leu Val Ser 
385                 390                 395                 400 


Cys Pro Arg Asn Val Ser Glu Cys Ser His Asp Cys Val Leu Thr Ser 
                405                 410                 415     


Glu Gly Pro Leu Cys Phe Cys Pro Glu Gly Ser Val Leu Glu Arg Asp 
            420                 425                 430         


Gly Lys Thr Cys Ser Gly Cys Ser Ser Pro Asp Asn Gly Gly Cys Ser 
        435                 440                 445             


Gln Leu Cys Val Pro Leu Ser Pro Val Ser Trp Glu Cys Asp Cys Phe 
    450                 455                 460                 


Pro Gly Tyr Asp Leu Gln Leu Asp Glu Lys Ser Cys Ala Ala Ser Gly 
465                 470                 475                 480 


Pro Gln Pro Phe Leu Leu Phe Ala Asn Ser Gln Asp Ile Arg His Met 
                485                 490                 495     


His Phe Asp Gly Thr Asp Tyr Gly Thr Leu Leu Ser Gln Gln Met Gly 
            500                 505                 510         


Met Val Tyr Ala Leu Asp His Asp Pro Val Glu Asn Lys Ile Tyr Phe 
        515                 520                 525             


Ala His Thr Ala Leu Lys Trp Ile Glu Arg Ala Asn Met Asp Gly Ser 
    530                 535                 540                 


Gln Arg Glu Arg Leu Ile Glu Glu Gly Val Asp Val Pro Glu Gly Leu 
545                 550                 555                 560 


Ala Val Asp Trp Ile Gly Arg Arg Phe Tyr Trp Thr Asp Arg Gly Lys 
                565                 570                 575     


Ser Leu Ile Gly Arg Ser Asp Leu Asn Gly Lys Arg Ser Lys Ile Ile 
            580                 585                 590         


Thr Lys Glu Asn Ile Ser Gln Pro Arg Gly Ile Ala Val His Pro Met 
        595                 600                 605             


Ala Lys Arg Leu Phe Trp Thr Asp Thr Gly Ile Asn Pro Arg Ile Glu 
    610                 615                 620                 


Ser Ser Ser Leu Gln Gly Leu Gly Arg Leu Val Ile Ala Ser Ser Asp 
625                 630                 635                 640 


Leu Ile Trp Pro Ser Gly Ile Thr Ile Asp Phe Leu Thr Asp Lys Leu 
                645                 650                 655     


Tyr Trp Cys Asp Ala Lys Gln Ser Val Ile Glu Met Ala Asn Leu Asp 
            660                 665                 670         


Gly Ser Lys Arg Arg Arg Leu Thr Gln Asn Asp Val Gly His Pro Phe 
        675                 680                 685             


Ala Val Ala Val Phe Glu Asp Tyr Val Trp Phe Ser Asp Trp Ala Met 
    690                 695                 700                 


Pro Ser Val Met Arg Val Asn Lys Arg Thr Gly Lys Asp Arg Val Arg 
705                 710                 715                 720 


Leu Gln Gly Ser Met Leu Lys Pro Ser Ser Leu Val Val Val His Pro 
                725                 730                 735     


Leu Ala Lys Pro Gly Ala Asp Pro Cys Leu Tyr Gln Asn Gly Gly Cys 
            740                 745                 750         


Glu His Ile Cys Lys Lys Arg Leu Gly Thr Ala Trp Cys Ser Cys Arg 
        755                 760                 765             


Glu Gly Phe Met Lys Ala Ser Asp Gly Lys Thr Cys Leu Ala Leu Asp 
    770                 775                 780                 


Gly His Gln Leu Leu Ala Gly Gly Glu Val Asp Leu Lys Asn Gln Val 
785                 790                 795                 800 


Thr Pro Leu Asp Ile Leu Ser Lys Thr Arg Val Ser Glu Asp Asn Ile 
                805                 810                 815     


Thr Glu Ser Gln His Met Leu Val Ala Glu Ile Met Val Ser Asp Gln 
            820                 825                 830         


Asp Asp Cys Ala Pro Val Gly Cys Ser Met Tyr Ala Arg Cys Ile Ser 
        835                 840                 845             


Glu Gly Glu Asp Ala Thr Cys Gln Cys Leu Lys Gly Phe Ala Gly Asp 
    850                 855                 860                 


Gly Lys Leu Cys Ser Asp Ile Asp Glu Cys Glu Met Gly Val Pro Val 
865                 870                 875                 880 


Cys Pro Pro Ala Ser Ser Lys Cys Ile Asn Thr Glu Gly Gly Tyr Val 
                885                 890                 895     


Cys Arg Cys Ser Glu Gly Tyr Gln Gly Asp Gly Ile His Cys Leu Asp 
            900                 905                 910         


Ser Thr Pro Pro Pro His Leu Arg Glu Asp Asp His His Tyr Ser Val 
        915                 920                 925             


Arg Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu 
    930                 935                 940                 


His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys 
945                 950                 955                 960 


Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu 
                965                 970                 975     


Lys Trp Trp Glu Leu Arg His Ala Gly His Gly Gln Gln Gln Lys Val 
            980                 985                 990         


Ile Val Val Ala Val Cys Val Val  Val Leu Val Met Leu  Leu Leu Leu 
        995                 1000                 1005             


Ser Leu  Trp Gly Ala His Tyr  Tyr Arg Thr Gln Lys  Leu Leu Ser 
    1010                 1015                 1020             


Lys Asn  Pro Lys Asn Pro Tyr  Glu Glu Ser Ser Arg  Asp Val Arg 
    1025                 1030                 1035             


Ser Arg  Arg Pro Ala Asp Thr  Glu Asp Gly Met Ser  Ser Cys Pro 
    1040                 1045                 1050             


Gln Pro  Trp Phe Val Val Ile  Lys Glu His Gln Asp  Leu Lys Asn 
    1055                 1060                 1065             


Gly Gly  Gln Pro Val Ala Gly  Glu Asp Gly Gln Ala  Ala Asp Gly 
    1070                 1075                 1080             


Ser Met  Gln Pro Thr Ser Trp  Arg Gln Glu Pro Gln  Leu Cys Gly 
    1085                 1090                 1095             


Met Gly  Thr Glu Gln Gly Cys  Trp Ile Pro Val Ser  Ser Asp Lys 
    1100                 1105                 1110             


Gly Ser  Cys Pro Gln Val Met  Glu Arg Ser Phe His  Met Pro Ser 
    1115                 1120                 1125             


Tyr Gly  Thr Gln Thr Leu Glu  Gly Gly Val Glu Lys  Pro His Ser 
    1130                 1135                 1140             


Leu Leu  Ser Ala Asn Pro Leu  Trp Gln Gln Arg Ala  Leu Asp Pro 
    1145                 1150                 1155             


Pro His  Gln Met Glu Leu Thr  Gln 
    1160                 1165     


<210>  73
<211>  4815
<212>  DNA
<213>  Homo sapiens

<400>  73
agtggcgtcg gaactgcaaa gcacctgtga gcttgcggaa gtcagttcag actccagccc       60

gctccagccc ggcccgaccc gaccgcaccc ggcgcctgcc ctcgctcggc gtccccggcc      120

agccatgggc ccttggagcc gcagcctctc ggcgctgctg ctgctgctgc aggtctcctc      180

ttggctctgc caggagccgg agccctgcca ccctggcttt gacgccgaga gctacacgtt      240

cacggtgccc cggcgccacc tggagagagg ccgcgtcctg ggcagagtga attttgaaga      300

ttgcaccggt cgacaaagga cagcctattt ttccctcgac acccgattca aagtgggcac      360

agatggtgtg attacagtca aaaggcctct acggtttcat aacccacaga tccatttctt      420

ggtctacgcc tgggactcca cctacagaaa gttttccacc aaagtcacgc tgaatacagt      480

ggggcaccac caccgccccc cgccccatca ggcctccgtt tctggaatcc aagcagaatt      540

gctcacattt cccaactcct ctcctggcct cagaagacag aagagagact gggttattcc      600

tcccatcagc tgcccagaaa atgaaaaagg cccatttcct aaaaacctgg ttcagatcaa      660

atccaacaaa gacaaagaag gcaaggtttt ctacagcatc actggccaag gagctgacac      720

accccctgtt ggtgtcttta ttattgaaag agaaacagga tggctgaagg tgacagagcc      780

tctggataga gaacgcattg ccacatacac tctcttctct cacgctgtgt catccaacgg      840

gaatgcagtt gaggatccaa tggagatttt gatcacggta accgatcaga atgacaacaa      900

gcccgaattc acccaggagg tctttaaggg gtctgtcatg gaaggtgctc ttccaggaac      960

ctctgtgatg gaggtcacag ccacagacgc ggacgatgat gtgaacacct acaatgccgc     1020

catcgcttac accatcctca gccaagatcc tgagctccct gacaaaaata tgttcaccat     1080

taacaggaac acaggagtca tcagtgtggt caccactggg ctggaccgag agagtttccc     1140

tacgtatacc ctggtggttc aagctgctga ccttcaaggt gaggggttaa gcacaacagc     1200

aacagctgtg atcacagtca ctgacaccaa cgataatcct ccgatcttca atcccaccac     1260

gtacaagggt caggtgcctg agaacgaggc taacgtcgta atcaccacac tgaaagtgac     1320

tgatgctgat gcccccaata ccccagcgtg ggaggctgta tacaccatat tgaatgatga     1380

tggtggacaa tttgtcgtca ccacaaatcc agtgaacaac gatggcattt tgaaaacagc     1440

aaagggcttg gattttgagg ccaagcagca gtacattcta cacgtagcag tgacgaatgt     1500

ggtacctttt gaggtctctc tcaccacctc cacagccacc gtcaccgtgg atgtgctgga     1560

tgtgaatgaa gcccccatct ttgtgcctcc tgaaaagaga gtggaagtgt ccgaggactt     1620

tggcgtgggc caggaaatca catcctacac tgcccaggag ccagacacat ttatggaaca     1680

gaaaataaca tatcggattt ggagagacac tgccaactgg ctggagatta atccggacac     1740

tggtgccatt tccactcggg ctgagctgga cagggaggat tttgagcacg tgaagaacag     1800

cacgtacaca gccctaatca tagctacaga caatggttct ccagttgcta ctggaacagg     1860

gacacttctg ctgatcctgt ctgatgtgaa tgacaacgcc cccataccag aacctcgaac     1920

tatattcttc tgtgagagga atccaaagcc tcaggtcata aacatcattg atgcagacct     1980

tcctcccaat acatctccct tcacagcaga actaacacac ggggcgagtg ccaactggac     2040

cattcagtac aacgacccaa cccaagaatc tatcattttg aagccaaaga tggccttaga     2100

ggtgggtgac tacaaaatca atctcaagct catggataac cagaataaag accaagtgac     2160

caccttagag gtcagcgtgt gtgactgtga aggggccgct ggcgtctgta ggaaggcaca     2220

gcctgtcgaa gcaggattgc aaattcctgc cattctgggg attcttggag gaattcttgc     2280

tttgctaatt ctgattctgc tgctcttgct gtttcttcgg aggagagcgg tggtcaaaga     2340

gcccttactg cccccagagg atgacacccg ggacaacgtt tattactatg atgaagaagg     2400

aggcggagaa gaggaccagg actttgactt gagccagctg cacaggggcc tggacgctcg     2460

gcctgaagtg actcgtaacg acgttgcacc aaccctcatg agtgtccccc ggtatcttcc     2520

ccgccctgcc aatcccgatg aaattggaaa ttttattgat gaaaatctga aagcggctga     2580

tactgacccc acagccccgc cttatgattc tctgctcgtg tttgactatg aaggaagcgg     2640

ttccgaagct gctagtctga gctccctgaa ctcctcagag tcagacaaag accaggacta     2700

tgactacttg aacgaatggg gcaatcgctt caagaagctg gctgacatgt acggaggcgg     2760

cgaggacgac taggggactc gagagaggcg ggccccagac ccatgtgctg ggaaatgcag     2820

aaatcacgtt gctggtggtt tttcagctcc cttcccttga gatgagtttc tggggaaaaa     2880

aaagagactg gttagtgatg cagttagtat agctttatac tctctccact ttatagctct     2940

aataagtttg tgttagaaaa gtttcgactt atttcttaaa gctttttttt ttttcccatc     3000

actctttaca tggtggtgat gtccaaaaga tacccaaatt ttaatattcc agaagaacaa     3060

ctttagcatc agaaggttca cccagcacct tgcagatttt cttaaggaat tttgtctcac     3120

ttttaaaaag aaggggagaa gtcagctact ctagttctgt tgttttgtgt atataatttt     3180

ttaaaaaaaa tttgtgtgct tctgctcatt actacactgg tgtgtccctc tgcctttttt     3240

ttttttttaa gacagggtct cattctatcg gccaggctgg agtgcagtgg tgcaatcaca     3300

gctcactgca gccttgtcct cccaggctca agctatcctt gcacctcagc ctcccaagta     3360

gctgggacca caggcatgca ccactacgca tgactaattt tttaaatatt tgagacgggg     3420

tctccctgtg ttacccaggc tggtctcaaa ctcctgggct caagtgatcc tcccatcttg     3480

gcctcccaga gtattgggat tacagacatg agccactgca cctgcccagc tccccaactc     3540

cctgccattt tttaagagac agtttcgctc catcgcccag gcctgggatg cagtgatgtg     3600

atcatagctc actgtaacct caaactctgg ggctcaagca gttctcccac cagcctcctt     3660

tttatttttt tgtacagatg gggtcttgct atgttgccca agctggtctt aaactcctgg     3720

cctcaagcaa tccttctgcc ttggcccccc aaagtgctgg gattgtgggc atgagctgct     3780

gtgcccagcc tccatgtttt aatatcaact ctcactcctg aattcagttg ctttgcccaa     3840

gataggagtt ctctgatgca gaaattattg ggctctttta gggtaagaag tttgtgtctt     3900

tgtctggcca catcttgact aggtattgtc tactctgaag acctttaatg gcttccctct     3960

ttcatctcct gagtatgtaa cttgcaatgg gcagctatcc agtgacttgt tctgagtaag     4020

tgtgttcatt aatgtttatt tagctctgaa gcaagagtga tatactccag gacttagaat     4080

agtgcctaaa gtgctgcagc caaagacaga gcggaactat gaaaagtggg cttggagatg     4140

gcaggagagc ttgtcattga gcctggcaat ttagcaaact gatgctgagg atgattgagg     4200

tgggtctacc tcatctctga aaattctgga aggaatggag gagtctcaac atgtgtttct     4260

gacacaagat ccgtggtttg tactcaaagc ccagaatccc caagtgcctg cttttgatga     4320

tgtctacaga aaatgctggc tgagctgaac acatttgccc aattccaggt gtgcacagaa     4380

aaccgagaat attcaaaatt ccaaattttt ttcttaggag caagaagaaa atgtggccct     4440

aaagggggtt agttgagggg tagggggtag tgaggatctt gatttggatc tctttttatt     4500

taaatgtgaa tttcaacttt tgacaatcaa agaaaagact tttgttgaaa tagctttact     4560

gtttctcaag tgttttggag aaaaaaatca accctgcaat cactttttgg aattgtcttg     4620

atttttcggc agttcaagct atatcgaata tagttctgtg tagagaatgt cactgtagtt     4680

ttgagtgtat acatgtgtgg gtgctgataa ttgtgtattt tctttggggg tggaaaagga     4740

aaacaattca agctgagaaa agtattctca aagatgcatt tttataaatt ttattaaaca     4800

attttgttaa accat                                                      4815


<210>  74
<211>  882
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Gly Pro Trp Ser Arg Ser Leu Ser Ala Leu Leu Leu Leu Leu Gln 
1               5                   10                  15      


Val Ser Ser Trp Leu Cys Gln Glu Pro Glu Pro Cys His Pro Gly Phe 
            20                  25                  30          


Asp Ala Glu Ser Tyr Thr Phe Thr Val Pro Arg Arg His Leu Glu Arg 
        35                  40                  45              


Gly Arg Val Leu Gly Arg Val Asn Phe Glu Asp Cys Thr Gly Arg Gln 
    50                  55                  60                  


Arg Thr Ala Tyr Phe Ser Leu Asp Thr Arg Phe Lys Val Gly Thr Asp 
65                  70                  75                  80  


Gly Val Ile Thr Val Lys Arg Pro Leu Arg Phe His Asn Pro Gln Ile 
                85                  90                  95      


His Phe Leu Val Tyr Ala Trp Asp Ser Thr Tyr Arg Lys Phe Ser Thr 
            100                 105                 110         


Lys Val Thr Leu Asn Thr Val Gly His His His Arg Pro Pro Pro His 
        115                 120                 125             


Gln Ala Ser Val Ser Gly Ile Gln Ala Glu Leu Leu Thr Phe Pro Asn 
    130                 135                 140                 


Ser Ser Pro Gly Leu Arg Arg Gln Lys Arg Asp Trp Val Ile Pro Pro 
145                 150                 155                 160 


Ile Ser Cys Pro Glu Asn Glu Lys Gly Pro Phe Pro Lys Asn Leu Val 
                165                 170                 175     


Gln Ile Lys Ser Asn Lys Asp Lys Glu Gly Lys Val Phe Tyr Ser Ile 
            180                 185                 190         


Thr Gly Gln Gly Ala Asp Thr Pro Pro Val Gly Val Phe Ile Ile Glu 
        195                 200                 205             


Arg Glu Thr Gly Trp Leu Lys Val Thr Glu Pro Leu Asp Arg Glu Arg 
    210                 215                 220                 


Ile Ala Thr Tyr Thr Leu Phe Ser His Ala Val Ser Ser Asn Gly Asn 
225                 230                 235                 240 


Ala Val Glu Asp Pro Met Glu Ile Leu Ile Thr Val Thr Asp Gln Asn 
                245                 250                 255     


Asp Asn Lys Pro Glu Phe Thr Gln Glu Val Phe Lys Gly Ser Val Met 
            260                 265                 270         


Glu Gly Ala Leu Pro Gly Thr Ser Val Met Glu Val Thr Ala Thr Asp 
        275                 280                 285             


Ala Asp Asp Asp Val Asn Thr Tyr Asn Ala Ala Ile Ala Tyr Thr Ile 
    290                 295                 300                 


Leu Ser Gln Asp Pro Glu Leu Pro Asp Lys Asn Met Phe Thr Ile Asn 
305                 310                 315                 320 


Arg Asn Thr Gly Val Ile Ser Val Val Thr Thr Gly Leu Asp Arg Glu 
                325                 330                 335     


Ser Phe Pro Thr Tyr Thr Leu Val Val Gln Ala Ala Asp Leu Gln Gly 
            340                 345                 350         


Glu Gly Leu Ser Thr Thr Ala Thr Ala Val Ile Thr Val Thr Asp Thr 
        355                 360                 365             


Asn Asp Asn Pro Pro Ile Phe Asn Pro Thr Thr Tyr Lys Gly Gln Val 
    370                 375                 380                 


Pro Glu Asn Glu Ala Asn Val Val Ile Thr Thr Leu Lys Val Thr Asp 
385                 390                 395                 400 


Ala Asp Ala Pro Asn Thr Pro Ala Trp Glu Ala Val Tyr Thr Ile Leu 
                405                 410                 415     


Asn Asp Asp Gly Gly Gln Phe Val Val Thr Thr Asn Pro Val Asn Asn 
            420                 425                 430         


Asp Gly Ile Leu Lys Thr Ala Lys Gly Leu Asp Phe Glu Ala Lys Gln 
        435                 440                 445             


Gln Tyr Ile Leu His Val Ala Val Thr Asn Val Val Pro Phe Glu Val 
    450                 455                 460                 


Ser Leu Thr Thr Ser Thr Ala Thr Val Thr Val Asp Val Leu Asp Val 
465                 470                 475                 480 


Asn Glu Ala Pro Ile Phe Val Pro Pro Glu Lys Arg Val Glu Val Ser 
                485                 490                 495     


Glu Asp Phe Gly Val Gly Gln Glu Ile Thr Ser Tyr Thr Ala Gln Glu 
            500                 505                 510         


Pro Asp Thr Phe Met Glu Gln Lys Ile Thr Tyr Arg Ile Trp Arg Asp 
        515                 520                 525             


Thr Ala Asn Trp Leu Glu Ile Asn Pro Asp Thr Gly Ala Ile Ser Thr 
    530                 535                 540                 


Arg Ala Glu Leu Asp Arg Glu Asp Phe Glu His Val Lys Asn Ser Thr 
545                 550                 555                 560 


Tyr Thr Ala Leu Ile Ile Ala Thr Asp Asn Gly Ser Pro Val Ala Thr 
                565                 570                 575     


Gly Thr Gly Thr Leu Leu Leu Ile Leu Ser Asp Val Asn Asp Asn Ala 
            580                 585                 590         


Pro Ile Pro Glu Pro Arg Thr Ile Phe Phe Cys Glu Arg Asn Pro Lys 
        595                 600                 605             


Pro Gln Val Ile Asn Ile Ile Asp Ala Asp Leu Pro Pro Asn Thr Ser 
    610                 615                 620                 


Pro Phe Thr Ala Glu Leu Thr His Gly Ala Ser Ala Asn Trp Thr Ile 
625                 630                 635                 640 


Gln Tyr Asn Asp Pro Thr Gln Glu Ser Ile Ile Leu Lys Pro Lys Met 
                645                 650                 655     


Ala Leu Glu Val Gly Asp Tyr Lys Ile Asn Leu Lys Leu Met Asp Asn 
            660                 665                 670         


Gln Asn Lys Asp Gln Val Thr Thr Leu Glu Val Ser Val Cys Asp Cys 
        675                 680                 685             


Glu Gly Ala Ala Gly Val Cys Arg Lys Ala Gln Pro Val Glu Ala Gly 
    690                 695                 700                 


Leu Gln Ile Pro Ala Ile Leu Gly Ile Leu Gly Gly Ile Leu Ala Leu 
705                 710                 715                 720 


Leu Ile Leu Ile Leu Leu Leu Leu Leu Phe Leu Arg Arg Arg Ala Val 
                725                 730                 735     


Val Lys Glu Pro Leu Leu Pro Pro Glu Asp Asp Thr Arg Asp Asn Val 
            740                 745                 750         


Tyr Tyr Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp Phe Asp 
        755                 760                 765             


Leu Ser Gln Leu His Arg Gly Leu Asp Ala Arg Pro Glu Val Thr Arg 
    770                 775                 780                 


Asn Asp Val Ala Pro Thr Leu Met Ser Val Pro Arg Tyr Leu Pro Arg 
785                 790                 795                 800 


Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile Asp Glu Asn Leu Lys 
                805                 810                 815     


Ala Ala Asp Thr Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu Leu Val 
            820                 825                 830         


Phe Asp Tyr Glu Gly Ser Gly Ser Glu Ala Ala Ser Leu Ser Ser Leu 
        835                 840                 845             


Asn Ser Ser Glu Ser Asp Lys Asp Gln Asp Tyr Asp Tyr Leu Asn Glu 
    850                 855                 860                 


Trp Gly Asn Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly Gly Glu 
865                 870                 875                 880 


Asp Asp 
        


<210>  75
<211>  3328
<212>  DNA
<213>  Homo sapiens

<400>  75
ccggaagtgc tgcgagccct gggccacgct ggccgtgctg gcagtgggcc gcctcgatcc       60

ctctgcagtc tttcccttga ggctccaaga ccagcaggtg aggcctcgcg gcgctgaaac      120

cgtgaggccc ggaccacagg ctccagatgg accctgggaa ggacaaagag ggggtgcccc      180

agccctcagg gccgccagca aggaagaaat ttgtgatacc cctcgacgag gatgaggtcc      240

ctcctggagt ggccaagccc ttattccgat ctacacagag ccttcccact gtggacacct      300

cggcccaggc ggcccctcag acctacgccg aatatgccat ctcacagcct ctggaagggg      360

ctggggccac gtgccccaca gggtcagagc ccctggcagg agagacgccc aaccaggccc      420

tgaaacccgg ggcaaaatcc aacagcatca ttgtgagccc tcggcagagg ggcaatcccg      480

tactgaagtt cgtgcgcaat gtgccctggg aatttggcga cgtaattccc gactatgtgc      540

tgggccagag cacctgtgcc ctgttcctca gcctccgcta ccacaacctg cacccagact      600

acatccatgg gcggctgcag agcctgggga agaacttcgc cttgcgggtc ctgcttgtcc      660

aggtggatgt gaaagatccc cagcaggccc tcaaggagct ggctaagatg tgtatcctgg      720

ccgactgcac attgatcctc gcctggagcc ccgaggaagc tgggcggtac ctggagacct      780

acaaggccta tgagcagaaa ccagcggacc tcctgatgga gaagctagag caggacttcg      840

tctcccggtc tctggaacag ctcatcgccg catcaagaga agatctggcc ttatgcccag      900

gcctgggccc tcagaaagcc cggaggctgt ttgatgtcct gcacgagccc ttcttgaaag      960

taccctgatg accccagctg ccaaggaaac ccccagtgta ataataaatc gtcctcccag     1020

gccaggctcc tgctggctgc gctggtgcag tctctgggga gggattctgg gggtgtcacc     1080

ttctggtggc ccaggtgggc accttcagct ttctttagtt cctcagtttc ccgggggcag     1140

actacacagg ctgctgctgc tgctgcttcc gcttcttgtc ccggcctgtg ggagcctcct     1200

ccccagactc tgaattcagt ggcggccctg gcatctcctc ttggggcact gtctctggca     1260

tccggctttc ctgactctgc ttcttcctct tcttggtgga tcccggagtt gccctggctt     1320

caggctgtcc ctcccctggc agttcaggct ctagtggctg aattggctca gtcactgtgt     1380

gacctctctc tttcttcttc ttcttcttct tggtggatgt gggagctgcc tgaggctcaa     1440

ggtcatccgg cagctcaggc cccaccacct ctgtctctgg ctccactgtg gcatcttgct     1500

gtttttcttt cttcgtcttc tttttgggag ctgccagagc tgcctgggcc tgaggcttcg     1560

ctccttctgg ctgttgaggc gccatggtcc cccctgggga ctccagaggc ttcatctccg     1620

gctccactgg ctccatcgcc tccgtccctg gctccatcat tgccatctgt cccttttctt     1680

ttttcctctt cttcgtaggg ggcagaggga tggcttcctc cagtggctcc accttcacct     1740

gtggctgaga ctcaactgtc accccctcct ctggctccat cccttccgtc cccttttgcc     1800

tctttctctt tttggtcggg gacaggactg tgtcttctag aggctcagtg ttaatctgtt     1860

cctgcttcac tgtcttgtct tctggctcga aggtttcttt ccctttgggc ttcttcctct     1920

tcttggtggt ggacgggaac agcactccca gaggctccag tgtctccact gtgggctctg     1980

tccccacagg ccctgctgcc tctggttctt tcagctgctg attttttttc ttcttcttct     2040

tccgcacatc catttctggc gaccccaaag ccatgtccac ctccagggcc ccgtgcccat     2100

tcactgcctc ctgagtgact ggggcctctg tcacctgcat ctcctttttc ttcttccctg     2160

aggtgagcag gttgggggcc aaggctgacc taggccctgt gactggtggg ttgcccccaa     2220

aggcacagaa ccgaggcctc aggccaggag ggatctgtgg tgggggactt gctgggatgg     2280

gctgcagagg gctccctgac agggattgct ggggaccctc aaggatcctt agggtgccct     2340

ggggggctga ggcacaggtg agtccacctc ctgcctccgt tgagggggcc agcagggtcg     2400

cttctccagc ttggggacag ctgctgagga ctcgatagcg gtgccgcttg cctgccaatt     2460

tgcccttgac gatctgggag ccagagagag gcacatgccg cccattgaag ctacagagag     2520

aaacagggag ggcagaggct taagtggaac aggagaggga aggttttttg attttttttt     2580

tgtttttttt tgagagagtc ttgctctgtt gcctaggctg gagtgcagtg gcatgatctc     2640

ggctcactgc aatgtccacc tcctgggttc aagcgattct cctgcctcag cctctcaagt     2700

agctgggatt acaggcacct gccaccacgc ccagccaatt tttgtatttt tagtagagac     2760

aatttcacta tgttggccag gctggtcttg aactcctgac ctcaagtgat ctgctcgcct     2820

cggcctccca aaggatggga ttacaggcac cagccactgc gcctggctgg cctctggttt     2880

ttaataaaac atgactagag tgactccatc ttaaagtgag tagctaggca cttacaaggt     2940

tcatgcttat ggcctgaaaa taaccacatc ccaggctgac caccaattat aattacagaa     3000

tatttatggc catacagaac atgttccacc aagcctgcag aatgtccaaa tgtcctaaga     3060

atgcagcccc cattacttaa atataacata aatgagcaag cttaggttgc aggattaatg     3120

gtcgtggata acaccaatag cccctacctt tagtgagctt atctgcacac tccaagttta     3180

actatagttc cttatagttt cttataagta gaaatactaa caaagggctg tgggtttctc     3240

cccctgcttt ctgaggacac tctactctgt aaaggagtag tttccaataa acttgtttct     3300

ttcactgtgc aaaaaaaaaa aaaaaaaa                                        3328


<210>  76
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Asp Pro Gly Lys Asp Lys Glu Gly Val Pro Gln Pro Ser Gly Pro 
1               5                   10                  15      


Pro Ala Arg Lys Lys Phe Val Ile Pro Leu Asp Glu Asp Glu Val Pro 
            20                  25                  30          


Pro Gly Val Ala Lys Pro Leu Phe Arg Ser Thr Gln Ser Leu Pro Thr 
        35                  40                  45              


Val Asp Thr Ser Ala Gln Ala Ala Pro Gln Thr Tyr Ala Glu Tyr Ala 
    50                  55                  60                  


Ile Ser Gln Pro Leu Glu Gly Ala Gly Ala Thr Cys Pro Thr Gly Ser 
65                  70                  75                  80  


Glu Pro Leu Ala Gly Glu Thr Pro Asn Gln Ala Leu Lys Pro Gly Ala 
                85                  90                  95      


Lys Ser Asn Ser Ile Ile Val Ser Pro Arg Gln Arg Gly Asn Pro Val 
            100                 105                 110         


Leu Lys Phe Val Arg Asn Val Pro Trp Glu Phe Gly Asp Val Ile Pro 
        115                 120                 125             


Asp Tyr Val Leu Gly Gln Ser Thr Cys Ala Leu Phe Leu Ser Leu Arg 
    130                 135                 140                 


Tyr His Asn Leu His Pro Asp Tyr Ile His Gly Arg Leu Gln Ser Leu 
145                 150                 155                 160 


Gly Lys Asn Phe Ala Leu Arg Val Leu Leu Val Gln Val Asp Val Lys 
                165                 170                 175     


Asp Pro Gln Gln Ala Leu Lys Glu Leu Ala Lys Met Cys Ile Leu Ala 
            180                 185                 190         


Asp Cys Thr Leu Ile Leu Ala Trp Ser Pro Glu Glu Ala Gly Arg Tyr 
        195                 200                 205             


Leu Glu Thr Tyr Lys Ala Tyr Glu Gln Lys Pro Ala Asp Leu Leu Met 
    210                 215                 220                 


Glu Lys Leu Glu Gln Asp Phe Val Ser Arg Ser Leu Glu Gln Leu Ile 
225                 230                 235                 240 


Ala Ala Ser Arg Glu Asp Leu Ala Leu Cys Pro Gly Leu Gly Pro Gln 
                245                 250                 255     


Lys Ala Arg Arg Leu Phe Asp Val Leu His Glu Pro Phe Leu Lys Val 
            260                 265                 270         


Pro 
    


<210>  77
<211>  2204
<212>  DNA
<213>  Homo sapiens

<400>  77
ggagccccgg ctcctaggct gacagaccag cccagatcca gtggcccgga ggggcctgag       60

ctaaatccgc aggacctggg taacacgagg aagtcggttt ggtcccttta gggctccgga      120

tatctttggt gacttgtcca ctccagtgtg gcatcatgtg gcagctgctc ctcccaactg      180

ctctgctact tctagtttca gctggcatgc ggactgaaga tctcccaaag gctgtggtgt      240

tcctggagcc tcaatggtac agggtgctcg agaaggacag tgtgactctg aagtgccagg      300

gagcctactc ccctgaggac aattccacac agtggtttca caatgagagc ctcatctcaa      360

gccaggcctc gagctacttc attgacgctg ccacagtcga cgacagtgga gagtacaggt      420

gccagacaaa cctctccacc ctcagtgacc cggtgcagct agaagtccat atcggctggc      480

tgttgctcca ggcccctcgg tgggtgttca aggaggaaga ccctattcac ctgaggtgtc      540

acagctggaa gaacactgct ctgcataagg tcacatattt acagaatggc aaaggcagga      600

agtattttca tcataattct gacttctaca ttccaaaagc cacactcaaa gacagcggct      660

cctacttctg cagggggctt tttgggagta aaaatgtgtc ttcagagact gtgaacatca      720

ccatcactca aggtttggca gtgtcaacca tctcatcatt ctttccacct gggtaccaag      780

tctctttctg cttggtgatg gtactccttt ttgcagtgga cacaggacta tatttctctg      840

tgaagacaaa cattcgaagc tcaacaagag actggaagga ccataaattt aaatggagaa      900

aggaccctca agacaaatga cccccatccc atgggggtaa taagagcagt agcagcagca      960

tctctgaaca tttctctgga tttgcaaccc catcatcctc aggcctctct acaagcagca     1020

ggaaacatag aactcagagc cagatccctt atccaactct cgacttttcc ttggtctcca     1080

gtggaaggga aaagcccatg atcttcaagc agggaagccc cagtgagtag ctgcattcct     1140

agaaattgaa gtttcagagc tacacaaaca ctttttctgt cccaaccgtt ccctcacagc     1200

aaagcaacaa tacaggctag ggatggtaat cctttaaaca tacaaaaatt gctcgtgtta     1260

taaattaccc agtttagagg ggaaaaaaaa acaattattc ctaaataaat ggataagtag     1320

aattaatggt tgaggcagga ccatacagag tgtgggaact gctggggatc tagggaattc     1380

agtgggacca atgaaagcat ggctgagaaa tagcaggtag tccaggatag tctaagggag     1440

gtgttcccat ctgagcccag agataagggt gtcttcctag aacattagcc gtagtggaat     1500

taacaggaaa tcatgagggt gacgtagaat tgagtcttcc aggggactct atcagaactg     1560

gaccatctcc aagtatataa cgatgagtcc tcttaatgct aggagtagaa aatggtccta     1620

ggaaggggac tgaggattgc ggtggggggt ggggtggaaa agaaagtaca gaacaaaccc     1680

tgtgtcactg tcccaagttg ctaagtgaac agaactatct cagcatcaga atgagaaagc     1740

ctgagaagaa agaaccaacc acaagcacac aggaaggaaa gcgcaggagg tgaaaatgct     1800

ttcttggcca gggtagtaag aattagaggt taatgcaggg actgtaaaac caccttttct     1860

gcttcaatat ctaattcctg tgtagctttg ttcattgcat ttattaaaca aatgttgtat     1920

aaccaatact aaatgtacta ctgagcttcg ctgagttaag ttatgaaact ttcaaatcct     1980

tcatcatgtc agttccaatg aggtggggat ggagaagaca attgttgctt atgaaagaaa     2040

gctttagctg tctctgtttt gtaagcttta agcgcaacat ttcttggttc caataaagca     2100

ttttacaaga tcttgcatgc tactcttaga tagaagatgg gaaaaccatg gtaataaaat     2160

atgaatgata aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                      2204


<210>  78
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Phe 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp 
225                 230                 235                 240 


Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                245                 250                 



