
                                SEQUENCE LISTING

<110> Millendo Therapeutics, Inc.
      Mohideen, Pharis
      Owens, Julia Christine

<120> COMBINATION THERAPY FOR TREATING
  DISORDERS ASSOCIATED WITH EXCESS CORTISOL PRODUCTION
  

<130> 120205.407WO

<140> PCT                 
<141> 2016-04-05  

<150> US 62/143,713       
<151> 2015-04-06  

<160> 6

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 3551
<212> DNA
<213> Homo sapiens

<400> 1
cattggaatg gcactcaggg caaaggcaga ggtgtgcatg gcagtgccct ggctgtccct      60
gcaaagggca caggcactgg gcacgagagc cgcccgggtc cccaggacag tgctgccctt     120
tgaagccatg ccccggcgtc caggcaacag gtggctgagg ctgctgcaga tctggaggga     180
gcagggttat gaggacctgc acctggaagt acaccagacc ttccaggaac tagggcccat     240
tttcaggtac gacttgggag gagcaggcat ggtgtgtgtg atgctgccgg aggacgtgga     300
gaagctgcaa caggtggaca gcctgcatcc ccacaggatg agcctggagc cctgggtggc     360
ctacagacaa catcgtgggc acaaatgtgg cgtgttcttg ctgaatgggc ctgaatggcg     420
cttcaaccga ttgcggctga atccagaagt gctgtcgccc aacgctgtgc agaggttcct     480
cccgatggtg gatgcagtgg ccagggactt ctcccaggcc ctgaagaaga aggtgctgca     540
gaacgcccgg gggagcctga ccctggacgt ccagcccagc atcttccact acaccataga     600
agccagcaac ttggctcttt ttggagagcg gctgggcctg gttggccaca gccccagttc     660
tgccagcctg aacttcctcc atgccctgga ggtcatgttc aaatccaccg tccagctcat     720
gttcatgccc aggagcctgt ctcgctggac cagccccaag gtgtggaagg agcactttga     780
ggcctgggac tgcatcttcc agtacggcga caactgtatc cagaaaatct atcaggaact     840
ggccttcagc cgccctcaac agtacaccag catcgtggcg gagctcctgt tgaatgcgga     900
actgtcgcca gatgccatca aggccaactc tatggaactc actgcaggga gcgtggacac     960
gacggtgttt cccttgctga tgacgctctt tgagctggct cggaacccca acgtgcagca    1020
ggccctgcgc caggagagcc tggccgccgc agccagcatc agtgaacatc cccagaaggc    1080
aaccaccgag ctgcccttgc tgcgtgcggc cctcaaggag accttgcggc tctaccctgt    1140
gggtctgttt ctggagcgag tggcgagctc agacttggtg cttcagaact accacatccc    1200
agctgggaca ttggtgcgcg tgttcctcta ctctctgggt cgcaaccccg ccttgttccc    1260
gaggcctgag cgctataacc cccagcgctg gctagacatc aggggctccg gcaggaactt    1320
ctaccacgtg ccctttggct ttggcatgcg ccagtgcctt gggcggcgcc tggcagaggc    1380
agagatgctg ctgctgctgc accatgtgct gaaacacctc caggtggaga cactaaccca    1440
agaggacata aagatggtct acagcttcat attgaggccc agcatgttcc ccctcctcac    1500
cttcagagcc atcaactaat cacgtctctg cacccagggt cccagcctgg ccaccagcct    1560
ccctttctgc ctgaccccag gccacccctc ttctctccca catgcacagc ttcctgagtc    1620
acccctctgt ctaaccagcc ccagcacaaa tggaactccc gagggcctct aggaccaggg    1680
tttgccaggc taagcagcaa tgccagggca cagctgggga agatcttgct gaccttgtcc    1740
ccagccccac ctggcccttt ctccagcaag cactgtcctc tgggcagttt gcccccatcc    1800
ctcccagtgc tggctccagg ctcctcgtgt ggccatacaa gggtgctgtg gttttgtccc    1860
ttgccttcct gcctagtctc acatgtccct gttcctcttc ccctggccag ggcccctgcg    1920
cagactgtca gagtcattaa gcgggatccc agcatctcag agtccagtca agttccctcc    1980
tgcagcctga cccctaggca gctcgagcat gccctgagct ctctgaaagt tgtcaccctg    2040
gaatagggtc ctgcagggta gaataaaaag gcccctgtgg tcacttgtcc tgacatcccc    2100
attttcaagt gatacaactg agtctcgagg gacgtgtgtt ccccagctga tcgtgtcagc    2160
ctcatgcccc aggcctcatc tttcatggac caggccttgt tccaggagtg ggtgttgggt    2220
cctctgcttc ctgtgctgtc ccctggggaa ggtcccgagg atgctgtcag gagatggaag    2280
agtcatgtgg ggtgggaacc tggggtgtgg ttccagaaat gtttttggca acaggagaga    2340
caggattggg ccaacaagga ctcagacgag ttttattgac tcatttctct ggttgatacg    2400
gagccatgtc atgtgccacg acctggggtg ggcacaggga ggctgcagtt tcctgcgtga    2460
acctgccttg ggcctcatct gctcctagcc cagcagagag agttgacccc tcctgaactg    2520
gccactcccc agtgctcccg tgcagggaga ggaagcaccc agtttgagag tgtacccagc    2580
cagactgtct ttatctccat ggattttcat cagggcaaag atcacagcag ccagctcctg    2640
gtggctgatg aggatcagag catttgttcc cccatgaaag gggaaatccc tatggcatca    2700
ttccagtggt ggtcagtaga tccaggacgc cctgcaggac tcagcctgta cagggagatg    2760
aagtgcccca ggttgggagc acacctagct agagttattt gtgttaatct attcaggatg    2820
ctctaagaaa acgccataga ctgggttgct gacaaacatc agaattctat ttctcatggt    2880
tctgaaggct tagaaggcta agatcaaggt gtcagcaggt tctgtgtctg gtgaggaccc    2940
acctcttgtt tcatagataa aaccttcttg ctgtgtcctc acatggtgga aaagggcaag    3000
acagctcaca gagacctctt ttataaggac gccagttcca ttcaagaggg cactgcctgc    3060
attcccttcc cccctcaaag gcccggccct gctattatcg tcaccttggt gactagattt    3120
cagcctatga attctggagg cggacacaaa aattcagatt aaactactct gcttctgttt    3180
ctctaaaatc tacatccttc tcatatacaa aatacatgca tttctcccca gtagccccaa    3240
atatcaactc attttagcat caactttaaa attgtagtcc aaagtgtgat ttaaatgtta    3300
tctgagtcaa acatgggtaa gactcaaggt acaatttatc ctgagtccaa ctgttcttgc    3360
tgcgaaccta tgaaatcaaa catgttatgt gcttccaaaa tacagtggtt ggagaggcat    3420
aggataaaca ttcccattcc agaaaggaga aacaggaaag aagaaaggag taacaagttt    3480
caagcaactc caaaattgaa tgtgacaaac agtattaaac cttaagcctc aagaaaaaaa    3540
aaaaaaaaaa a                                                         3551

<210> 2
<211> 503
<212> PRT
<213> Homo sapiens

<400> 2
Met Ala Leu Arg Ala Lys Ala Glu Val Cys Met Ala Val Pro Trp Leu
 1               5                  10                  15
Ser Leu Gln Arg Ala Gln Ala Leu Gly Thr Arg Ala Ala Arg Val Pro
            20                  25                  30
Arg Thr Val Leu Pro Phe Glu Ala Met Pro Arg Arg Pro Gly Asn Arg
        35                  40                  45
Trp Leu Arg Leu Leu Gln Ile Trp Arg Glu Gln Gly Tyr Glu Asp Leu
    50                  55                  60
His Leu Glu Val His Gln Thr Phe Gln Glu Leu Gly Pro Ile Phe Arg
65                  70                  75                  80
Tyr Asp Leu Gly Gly Ala Gly Met Val Cys Val Met Leu Pro Glu Asp
                85                  90                  95
Val Glu Lys Leu Gln Gln Val Asp Ser Leu His Pro His Arg Met Ser
            100                 105                 110
Leu Glu Pro Trp Val Ala Tyr Arg Gln His Arg Gly His Lys Cys Gly
        115                 120                 125
Val Phe Leu Leu Asn Gly Pro Glu Trp Arg Phe Asn Arg Leu Arg Leu
    130                 135                 140
Asn Pro Glu Val Leu Ser Pro Asn Ala Val Gln Arg Phe Leu Pro Met
145                 150                 155                 160
Val Asp Ala Val Ala Arg Asp Phe Ser Gln Ala Leu Lys Lys Lys Val
                165                 170                 175
Leu Gln Asn Ala Arg Gly Ser Leu Thr Leu Asp Val Gln Pro Ser Ile
            180                 185                 190
Phe His Tyr Thr Ile Glu Ala Ser Asn Leu Ala Leu Phe Gly Glu Arg
        195                 200                 205
Leu Gly Leu Val Gly His Ser Pro Ser Ser Ala Ser Leu Asn Phe Leu
    210                 215                 220
His Ala Leu Glu Val Met Phe Lys Ser Thr Val Gln Leu Met Phe Met
225                 230                 235                 240
Pro Arg Ser Leu Ser Arg Trp Thr Ser Pro Lys Val Trp Lys Glu His
                245                 250                 255
Phe Glu Ala Trp Asp Cys Ile Phe Gln Tyr Gly Asp Asn Cys Ile Gln
            260                 265                 270
Lys Ile Tyr Gln Glu Leu Ala Phe Ser Arg Pro Gln Gln Tyr Thr Ser
        275                 280                 285
Ile Val Ala Glu Leu Leu Leu Asn Ala Glu Leu Ser Pro Asp Ala Ile
    290                 295                 300
Lys Ala Asn Ser Met Glu Leu Thr Ala Gly Ser Val Asp Thr Thr Val
305                 310                 315                 320
Phe Pro Leu Leu Met Thr Leu Phe Glu Leu Ala Arg Asn Pro Asn Val
                325                 330                 335
Gln Gln Ala Leu Arg Gln Glu Ser Leu Ala Ala Ala Ala Ser Ile Ser
            340                 345                 350
Glu His Pro Gln Lys Ala Thr Thr Glu Leu Pro Leu Leu Arg Ala Ala
        355                 360                 365
Leu Lys Glu Thr Leu Arg Leu Tyr Pro Val Gly Leu Phe Leu Glu Arg
    370                 375                 380
Val Ala Ser Ser Asp Leu Val Leu Gln Asn Tyr His Ile Pro Ala Gly
385                 390                 395                 400
Thr Leu Val Arg Val Phe Leu Tyr Ser Leu Gly Arg Asn Pro Ala Leu
                405                 410                 415
Phe Pro Arg Pro Glu Arg Tyr Asn Pro Gln Arg Trp Leu Asp Ile Arg
            420                 425                 430
Gly Ser Gly Arg Asn Phe Tyr His Val Pro Phe Gly Phe Gly Met Arg
        435                 440                 445
Gln Cys Leu Gly Arg Arg Leu Ala Glu Ala Glu Met Leu Leu Leu Leu
    450                 455                 460
His His Val Leu Lys His Leu Gln Val Glu Thr Leu Thr Gln Glu Asp
465                 470                 475                 480
Ile Lys Met Val Tyr Ser Phe Ile Leu Arg Pro Ser Met Phe Pro Leu
                485                 490                 495
Leu Thr Phe Arg Ala Ile Asn
            500

<210> 3
<211> 4011
<212> DNA
<213> Homo sapiens

<400> 3
gggtagagac ggggtttcac cgtgttagcc aggatggtct ggatctcctg acctcgtgat      60
ccacccacct cggcctccta aagtgctggg attacagaca tgagccaccg cgcccagccc     120
tattcatccc ttttcaaaag tcagacccta ggaagctgga gggaggtggg gcatggtttt     180
acagtgaatt tctgatttca ctcagggtga taaatcagac tcttggggaa gcgggtggtg     240
gctctggaca gcagcaggaa tggggatcca gttagcaaca aatccatgga cctatgacag     300
gctgaaagcc accccttctc catctttggg aggttgccaa tgtctgattt aacactatcc     360
aatgaatgat cattgaaagt aaaaaataac tatcaactag cagaaaatat aaatggtaag     420
cattagcaca tatttcacat gtttatattt ggctctcaga ttgacctata aaacaaagtc     480
tgggaaattc tatatgatcc tgaaaaaatg atacgctggt ctggatggta gaataagttg     540
gagaaatgtt taagccaaaa tgcagtctta ccaatgactt tttattttat tttattaatt     600
ttcaggattt ttggtataca ggtggttttt ggttacatgg aaaagttctt tactggtgat     660
ttctgagatt ttagttcacc ccttatcctg agcagtgtac actgttccca atatgtagcc     720
ttttatccct caccccctct aagttcaaga agactatggt cctgcagaaa gctttatatg     780
taattaacat atctttatct ttatctttat aggcagtaga ctcatctttt gaaacagatt     840
ccattaagag tgaatgtgta ccctccctct agcctttatt attactgttt ttgctattac     900
atgtgttagt gtatgtgaat ttaatgctta aaaatgtatc ccattggcta ctatggcaaa     960
aggttgactc ataagagttt agcacgggtt aagatctgaa agttttctcc cagcctctta    1020
tcactggcgc agacttcaca attcatggaa gccaccagtg agatgacatt gcctcaggca    1080
gttactattt ttatattcta taactcgagg agctcagggt ttcggaaatc attaaacttt    1140
ttttgtcctt ttaaagttgg agacagcaat tgtagacagc cttccagtgg gttatctttt    1200
tgtgtctcct tacctgtgga gaagcctatt agctgggata tgtagttaaa tagctatatt    1260
tatatatatc cagggcaccc cgaattcggg agagcttccc ggagtcgacc ttcctgctgg    1320
ctgctctgtg accgcttccc ggctctgccc tcttggccga agtgcccgct gccgggcgcg    1380
ggcctcagac aatacaatgg tgggtgaaga gaagatgtct ctaagaaacc ggctgtcaaa    1440
gtccagggaa aatcctgagg aagatgaaga ccagagaaac cctgcaaagg agtccctaga    1500
gacacctagt aatggtcgaa ttgacataaa acagttgata gcaaagaaga taaagttgac    1560
agcagaggca gaggaattga agccattttt tatgaaggaa gttggcagtc actttgatga    1620
ttttgtgacc aatctcattg aaaagtcagc atcattagat aatggtgggt gcgctctcac    1680
aaccttttct gttcttgaag gagagaaaaa caaccataga gcgaaggatt tgagagcacc    1740
tccagaacaa ggaaagattt ttattgcaag gcgctctctc ttagatgaac tgcttgaagt    1800
ggaccacatc agaacaatat atcacatgtt tattgccctc ctcattctct ttatcctcag    1860
cacacttgta gtagattaca ttgatgaagg aaggctggtg cttgagttca gcctcctgtc    1920
ttatgctttt ggcaaatttc ctaccgttgt ttggacctgg tggatcatgt tcctgtctac    1980
attttcagtt ccctattttc tgtttcaaca ttgggccact ggctatagca agagttctca    2040
tccgctgatc cgttctctct tccatggctt tcttttcatg atcttccaga ttggagttct    2100
aggttttgga ccaacatatg ttgtgttagc atatacactg ccaccagctt cccggttcat    2160
cattatattc gagcagattc gttttgtaat gaaggcccac tcatttgtca gagagaacgt    2220
gcctcgggta ctaaattcag ctaaggagaa atcaagcact gttccaatac ctacagtcaa    2280
ccagtatttg tacttcttat ttgctcctac ccttatctac cgtgacagct atcccaggaa    2340
tcccactgta agatggggtt atgtcgctat gaagtttgca caggtctttg gttgcttttt    2400
ctatgtgtac tacatctttg aaaggctttg tgcccccttg tttcggaata tcaaacagga    2460
gcccttcagc gctcgtgttc tggtcctatg tgtatttaac tccatcttgc caggtgtgct    2520
gattctcttc cttacttttt ttgccttttt gcactgctgg ctcaatgcct ttgctgagat    2580
gttacgcttt ggtgacagga tgttctataa ggattggtgg aactccacgt catactccaa    2640
ctattataga acctggaatg tggtggtcca tgactggcta tattactatg cttacaagga    2700
ctttctctgg tttttctcca agagattcaa atctgctgcc atgttagctg tctttgctgt    2760
atctgctgta gtacacgaat atgccttggc tgtttgcttg agctttttct atcccgtgct    2820
cttcgtgctc ttcatgttct ttggaatggc tttcaacttc attgtcaatg atagtcggaa    2880
aaagccgatt tggaatgttc tgatgtggac ttctcttttc ttgggcaatg gagtcttact    2940
ctgcttttat tctcaagaat ggtatgcacg tcggcactgt cctctgaaaa atcccacatt    3000
tttggattat gtccggccac gttcctggac ttgtcgttac gtgttttaga agcttggact    3060
ttgtttcctc cttgtcactg aagattgggt agctccctga tttggagcca gctgtttcca    3120
gttgttactg aagttatctg tgttatttgg accactccag gctttacaga tgactcactc    3180
cattcctagg tcacttgaag ccaaactgtt ggaagttcac tggagtcttg tacacttaag    3240
cagagcagaa ctttttttgt ggggctgggt ggggggagaa gaccgactaa cagctgaagt    3300
aatgacagat tgttgctggg tcatatcagc tttatccctt ggtaattata tctgttttgt    3360
ttcttgactc tgtccaatca gagaataaac atcatagttt cttggccact gaattagcca    3420
aaacacttag gaagaaatca cttaaatacc tctggcttag aaattttttc atgcacactg    3480
ttggaatgta tgctaattga acatgcaatt ggggaagaaa aaatgtagaa tgatttttgc    3540
tatttctagt agaaagaaaa tgtctgtttt ccaaagataa tgttatacat cctattttgt    3600
aatttttttg aaaaaagttc aatgttcagt tttccttagt ttttaccttg ttttctctat    3660
aggtcatgat ttctgtgaag caaaaagatg ccttttacca tgaattcttg agtttacatc    3720
aataatattg tatattaagg ggatcagaag taggaaggaa aaaataagag atagcagagg    3780
aaaaagaaaa acatttcctc ttataacttc tgaagtaatt tgtaaaaaag atttgtagag    3840
tcaatcatgt gtttaaatta ttttatcaca aacttaacat ggaagatatt cctttttaac    3900
tttgtggtaa cttctttgaa gttatttaga aatatccttt ggaacaatta ttttattgtc    3960
taataaatat tgacttctct tgaattattt tgcagactag tgagtctgta c             4011

<210> 4
<211> 550
<212> PRT
<213> Homo sapiens

<400> 4
Met Val Gly Glu Glu Lys Met Ser Leu Arg Asn Arg Leu Ser Lys Ser
 1               5                  10                  15
Arg Glu Asn Pro Glu Glu Asp Glu Asp Gln Arg Asn Pro Ala Lys Glu
            20                  25                  30
Ser Leu Glu Thr Pro Ser Asn Gly Arg Ile Asp Ile Lys Gln Leu Ile
        35                  40                  45
Ala Lys Lys Ile Lys Leu Thr Ala Glu Ala Glu Glu Leu Lys Pro Phe
    50                  55                  60
Phe Met Lys Glu Val Gly Ser His Phe Asp Asp Phe Val Thr Asn Leu
65                  70                  75                  80
Ile Glu Lys Ser Ala Ser Leu Asp Asn Gly Gly Cys Ala Leu Thr Thr
                85                  90                  95
Phe Ser Val Leu Glu Gly Glu Lys Asn Asn His Arg Ala Lys Asp Leu
            100                 105                 110
Arg Ala Pro Pro Glu Gln Gly Lys Ile Phe Ile Ala Arg Arg Ser Leu
        115                 120                 125
Leu Asp Glu Leu Leu Glu Val Asp His Ile Arg Thr Ile Tyr His Met
    130                 135                 140
Phe Ile Ala Leu Leu Ile Leu Phe Ile Leu Ser Thr Leu Val Val Asp
145                 150                 155                 160
Tyr Ile Asp Glu Gly Arg Leu Val Leu Glu Phe Ser Leu Leu Ser Tyr
                165                 170                 175
Ala Phe Gly Lys Phe Pro Thr Val Val Trp Thr Trp Trp Ile Met Phe
            180                 185                 190
Leu Ser Thr Phe Ser Val Pro Tyr Phe Leu Phe Gln His Trp Ala Thr
        195                 200                 205
Gly Tyr Ser Lys Ser Ser His Pro Leu Ile Arg Ser Leu Phe His Gly
    210                 215                 220
Phe Leu Phe Met Ile Phe Gln Ile Gly Val Leu Gly Phe Gly Pro Thr
225                 230                 235                 240
Tyr Val Val Leu Ala Tyr Thr Leu Pro Pro Ala Ser Arg Phe Ile Ile
                245                 250                 255
Ile Phe Glu Gln Ile Arg Phe Val Met Lys Ala His Ser Phe Val Arg
            260                 265                 270
Glu Asn Val Pro Arg Val Leu Asn Ser Ala Lys Glu Lys Ser Ser Thr
        275                 280                 285
Val Pro Ile Pro Thr Val Asn Gln Tyr Leu Tyr Phe Leu Phe Ala Pro
    290                 295                 300
Thr Leu Ile Tyr Arg Asp Ser Tyr Pro Arg Asn Pro Thr Val Arg Trp
305                 310                 315                 320
Gly Tyr Val Ala Met Lys Phe Ala Gln Val Phe Gly Cys Phe Phe Tyr
                325                 330                 335
Val Tyr Tyr Ile Phe Glu Arg Leu Cys Ala Pro Leu Phe Arg Asn Ile
            340                 345                 350
Lys Gln Glu Pro Phe Ser Ala Arg Val Leu Val Leu Cys Val Phe Asn
        355                 360                 365
Ser Ile Leu Pro Gly Val Leu Ile Leu Phe Leu Thr Phe Phe Ala Phe
    370                 375                 380
Leu His Cys Trp Leu Asn Ala Phe Ala Glu Met Leu Arg Phe Gly Asp
385                 390                 395                 400
Arg Met Phe Tyr Lys Asp Trp Trp Asn Ser Thr Ser Tyr Ser Asn Tyr
                405                 410                 415
Tyr Arg Thr Trp Asn Val Val Val His Asp Trp Leu Tyr Tyr Tyr Ala
            420                 425                 430
Tyr Lys Asp Phe Leu Trp Phe Phe Ser Lys Arg Phe Lys Ser Ala Ala
        435                 440                 445
Met Leu Ala Val Phe Ala Val Ser Ala Val Val His Glu Tyr Ala Leu
    450                 455                 460
Ala Val Cys Leu Ser Phe Phe Tyr Pro Val Leu Phe Val Leu Phe Met
465                 470                 475                 480
Phe Phe Gly Met Ala Phe Asn Phe Ile Val Asn Asp Ser Arg Lys Lys
                485                 490                 495
Pro Ile Trp Asn Val Leu Met Trp Thr Ser Leu Phe Leu Gly Asn Gly
            500                 505                 510
Val Leu Leu Cys Phe Tyr Ser Gln Glu Trp Tyr Ala Arg Arg His Cys
        515                 520                 525
Pro Leu Lys Asn Pro Thr Phe Leu Asp Tyr Val Arg Pro Arg Ser Trp
    530                 535                 540
Thr Cys Arg Tyr Val Phe
545                 550

<210> 5
<211> 2936
<212> DNA
<213> Homo sapiens

<400> 5
ggaatggcac tcagggcaaa ggcagaggtg tgcgtggcag cgccctggct gtccctgcaa      60
agggcacggg cactgggcac tagagccgct cgggccccta ggacggtgct gccgtttgaa     120
gccatgcccc agcatccagg caacaggtgg ctgaggctgc tgcagatctg gagggagcag     180
ggttatgagc acctgcacct ggagatgcac cagaccttcc aggagctggg gcccattttc     240
aggtacaact tgggaggacc acgcatggtg tgtgtgatgc tgccggagga tgtggagaag     300
ctgcaacagg tggacagcct gcatccctgc aggatgatcc tggagccctg ggtggcctac     360
agacaacatc gtgggcacaa atgtggcgtg ttcttgttga atgggcctga atggcgcttc     420
aaccgattgc ggctgaaccc agatgtgctg tcgcccaagg ccgtgcagag gttcctcccg     480
atggtggatg cagtggccag ggacttctcc caggccctga agaagaaggt gctgcagaac     540
gcccggggga gcctgaccct ggacgtccag cccagcatct tccactacac catagaagcc     600
agcaacttag ctctttttgg agagcggctg ggcctggttg gccacagccc cagttctgcc     660
agcctgaact tcctccatgc cctggaggtc atgttcaaat ccaccgtcca gctcatgttc     720
atgcccagga gcctgtctcg ctggatcagc cccaaggtgt ggaaggagca ctttgaggcc     780
tgggactgca tcttccagta cggtgacaac tgtatccaga aaatctacca ggaactggcc     840
ttcaaccgcc ctcaacacta cacaggcatc gtggcggagc tcctgttgaa ggcggaactg     900
tcactagaag ccatcaaggc caactctatg gaactcactg cagggagcgt ggacacgaca     960
gcgtttccct tgctgatgac gctctttgag ctggctcgga accccgacgt gcagcagatc    1020
ctgcgccagg agagcctggc cgccgcagcc agcatcagtg aacatcccca gaaggcaacc    1080
accgagctgc ccttgctgcg ggcggccctc aaggagacct tgcggctcta ccctgtgggt    1140
ctgtttttgg agcgagtggt gagctcagac ttggtgcttc agaactacca catcccagct    1200
gggacattgg tacaggtttt cctctactcg ctgggtcgca atgccgcctt gttcccgagg    1260
cctgagcggt ataatcccca gcgctggcta gacatcaggg gctccggcag gaacttccac    1320
cacgtgccct ttggctttgg catgcgccag tgcctcgggc ggcgcctggc agaggcagag    1380
atgctgctgc tgctgcacca cgtgctgaag cacttcctgg tggagacact aactcaagag    1440
gacataaaga tggtctacag cttcatattg aggcctggca cgtcccccct cctcactttc    1500
agagcgatta actagtcttg catctgcacc cagggtccca gcctggccac cagcttccct    1560
ctgcctgacc ccaggccacc tgtcttctct cccacgtgca cagcttcctg agtcacccct    1620
ctgtccagcc agctcctgca caaatggaac tccccagggc ctccaggact ggggcttgcc    1680
aggcttgtca aatagcaagg ccagggcaca gctggagacg atcttgctgg cagggcctgg    1740
ccttgtcccc agctccacct ggccccttct ccagcaagca gtgccctctg gacagcttga    1800
ctctactccc agcgctggct ccaggctcct catgaggcca tgcaagggtg ctgtgatttt    1860
gtcccttgcc ttcctgccta gtctcacatg tccctgtccc tctcgccctg gccagggcct    1920
ctgtgcagac agtgtcagag tcattaagcg ggatcccagc atctcagagt ccagtcaagt    1980
tccctcctgc agcctgaccc caggcagctc gagcatgccc tgagctctct gaaagttgtc    2040
accctggaat acgatcctgc agggtagact aaaaaggccc ctgtggtcac ttatcctgac    2100
acattttcaa gtgatacaac tgagtctcga ggggcgtgtg ttccccagct gatcatgtca    2160
gcctcatgcc ccaggcctcg tctttcatgg accaggtctt gttcaagcag cgagtgttgg    2220
gtcctctgct tcctgagctg tcccctggag aaggtcccga ggatgctgtc aggagatgga    2280
agagtcatgt ggggtgggaa cctggggtgt ggttccagaa atgtttttgg caacaggaga    2340
gacaggattg ggccaacaag gactcagatg agttttattg actcattcct ctggttgata    2400
cggagccatg tcatgtgcca cgacctgggg tgggcacagg gaggctgcag ttccctacgt    2460
gaacctgcct tgggcctcat ctgctcctag cccagcagag agagttgacc cctcctgaac    2520
tggccactcc ccagtgctcc tgtgcaggga taggaagtgc cccagggtga gaacgtgccc    2580
agccacatca tctttatctc ctgggatttt cattagggca aagatctcag cagccagctc    2640
ctggtagctg atgaggatca gagcgtttgt tcccccatga aaggggaaat acttaggtaa    2700
tcattccagg tgtgttcagt agttccagga ctcagggact caggccagtc accctgtgac    2760
cgcaggttgc tttcccaccc tgggcaatgc agtgcagcat gggaaaggaa taagggggca    2820
acaaggtgca cagacctcag agatggcttc cttgtttatg gggctctcac agatacccat    2880
ccaactcctc tagtcagcac tagatcatgg gatcctaaaa taaaccttgg aaaaat        2936

<210> 6
<211> 503
<212> PRT
<213> Homo sapiens

<400> 6
Met Ala Leu Arg Ala Lys Ala Glu Val Cys Val Ala Ala Pro Trp Leu
 1               5                  10                  15
Ser Leu Gln Arg Ala Arg Ala Leu Gly Thr Arg Ala Ala Arg Ala Pro
            20                  25                  30
Arg Thr Val Leu Pro Phe Glu Ala Met Pro Gln His Pro Gly Asn Arg
        35                  40                  45
Trp Leu Arg Leu Leu Gln Ile Trp Arg Glu Gln Gly Tyr Glu His Leu
    50                  55                  60
His Leu Glu Met His Gln Thr Phe Gln Glu Leu Gly Pro Ile Phe Arg
65                  70                  75                  80
Tyr Asn Leu Gly Gly Pro Arg Met Val Cys Val Met Leu Pro Glu Asp
                85                  90                  95
Val Glu Lys Leu Gln Gln Val Asp Ser Leu His Pro Cys Arg Met Ile
            100                 105                 110
Leu Glu Pro Trp Val Ala Tyr Arg Gln His Arg Gly His Lys Cys Gly
        115                 120                 125
Val Phe Leu Leu Asn Gly Pro Glu Trp Arg Phe Asn Arg Leu Arg Leu
    130                 135                 140
Asn Pro Asp Val Leu Ser Pro Lys Ala Val Gln Arg Phe Leu Pro Met
145                 150                 155                 160
Val Asp Ala Val Ala Arg Asp Phe Ser Gln Ala Leu Lys Lys Lys Val
                165                 170                 175
Leu Gln Asn Ala Arg Gly Ser Leu Thr Leu Asp Val Gln Pro Ser Ile
            180                 185                 190
Phe His Tyr Thr Ile Glu Ala Ser Asn Leu Ala Leu Phe Gly Glu Arg
        195                 200                 205
Leu Gly Leu Val Gly His Ser Pro Ser Ser Ala Ser Leu Asn Phe Leu
    210                 215                 220
His Ala Leu Glu Val Met Phe Lys Ser Thr Val Gln Leu Met Phe Met
225                 230                 235                 240
Pro Arg Ser Leu Ser Arg Trp Ile Ser Pro Lys Val Trp Lys Glu His
                245                 250                 255
Phe Glu Ala Trp Asp Cys Ile Phe Gln Tyr Gly Asp Asn Cys Ile Gln
            260                 265                 270
Lys Ile Tyr Gln Glu Leu Ala Phe Asn Arg Pro Gln His Tyr Thr Gly
        275                 280                 285
Ile Val Ala Glu Leu Leu Leu Lys Ala Glu Leu Ser Leu Glu Ala Ile
    290                 295                 300
Lys Ala Asn Ser Met Glu Leu Thr Ala Gly Ser Val Asp Thr Thr Ala
305                 310                 315                 320
Phe Pro Leu Leu Met Thr Leu Phe Glu Leu Ala Arg Asn Pro Asp Val
                325                 330                 335
Gln Gln Ile Leu Arg Gln Glu Ser Leu Ala Ala Ala Ala Ser Ile Ser
            340                 345                 350
Glu His Pro Gln Lys Ala Thr Thr Glu Leu Pro Leu Leu Arg Ala Ala
        355                 360                 365
Leu Lys Glu Thr Leu Arg Leu Tyr Pro Val Gly Leu Phe Leu Glu Arg
    370                 375                 380
Val Val Ser Ser Asp Leu Val Leu Gln Asn Tyr His Ile Pro Ala Gly
385                 390                 395                 400
Thr Leu Val Gln Val Phe Leu Tyr Ser Leu Gly Arg Asn Ala Ala Leu
                405                 410                 415
Phe Pro Arg Pro Glu Arg Tyr Asn Pro Gln Arg Trp Leu Asp Ile Arg
            420                 425                 430
Gly Ser Gly Arg Asn Phe His His Val Pro Phe Gly Phe Gly Met Arg
        435                 440                 445
Gln Cys Leu Gly Arg Arg Leu Ala Glu Ala Glu Met Leu Leu Leu Leu
    450                 455                 460
His His Val Leu Lys His Phe Leu Val Glu Thr Leu Thr Gln Glu Asp
465                 470                 475                 480
Ile Lys Met Val Tyr Ser Phe Ile Leu Arg Pro Gly Thr Ser Pro Leu
                485                 490                 495
Leu Thr Phe Arg Ala Ile Asn
            500
