                               SEQUENCE LISTING

<110> THE J. DAVID GLADSTONE INSTITUTES, A TESTAMENTARY TRUST
      ESTABLISHED UNDER THE WILL OF J. DAVID GLADSTONE
 
<120> METHODS FOR INDUCING CELL DIVISION OF POSTMITOTIC CELLS

<130> 120902-8001.WO00

<140> PCT/US2016/026059
<141> 2016-04-05

<150> 62/151,321
<151> 2015-04-22

<150> 62/144,244
<151> 2015-04-07

<160> 20    

<170> PatentIn version 3.5

<210> 1
<211> 1923
<212> DNA
<213> Homo sapiens

<400> 1
agcgcggtga gtttgaaact gctcgcactt ggcttcaaag ctggctcttg gaaattgagc       60

ggagagcgac gcggttgttg tagctgccgc tgcggccgcc gcggaataat aagccgggat      120

ctaccatacc cattgactaa ctatggaaga ttataccaaa atagagaaaa ttggagaagg      180

tacctatgga gttgtgtata agggtagaca caaaactaca ggtcaagtgg tagccatgaa      240

aaaaatcaga ctagaaagtg aagaggaagg ggttcctagt actgcaattc gggaaatttc      300

tctattaaag gaacttcgtc atccaaatat agtcagtctt caggatgtgc ttatgcagga      360

ttccaggtta tatctcatct ttgagtttct ttccatggat ctgaagaaat acttggattc      420

tatccctcct ggtcagtaca tggattcttc acttgttaag agttatttat accaaatcct      480

acaggggatt gtgttttgtc actctagaag agttcttcac agagacttaa aacctcaaaa      540

tctcttgatt gatgacaaag gaacaattaa actggctgat tttggccttg ccagagcttt      600

tggaatacct atcagagtat atacacatga ggtagtaaca ctctggtaca gatctccaga      660

agtattgctg gggtcagctc gttactcaac tccagttgac atttggagta taggcaccat      720

atttgctgaa ctagcaacta agaaaccact tttccatggg gattcagaaa ttgatcaact      780

cttcaggatt ttcagagctt tgggcactcc caataatgaa gtgtggccag aagtggaatc      840

tttacaggac tataagaata catttcccaa atggaaacca ggaagcctag catcccatgt      900

caaaaacttg gatgaaaatg gcttggattt gctctcgaaa atgttaatct atgatccagc      960

caaacgaatt tctggcaaaa tggcactgaa tcatccatat tttaatgatt tggacaatca     1020

gattaagaag atgtagcttt ctgacaaaaa gtttccatat gttatatcaa cagatagttg     1080

tgtttttatt gttaactctt gtctattttt gtcttatata tatttctttg ttatcaaact     1140

tcagctgtac ttcgtcttct aatttcaaaa atataactta aaaatgtaaa tattctatat     1200

gaatttaaat ataattctgt aaatgtgtgt aggtctcact gtaacaacta tttgttacta     1260

taataaaact ataatattga tgtcaggaat caggaaaaaa tttgagttgg cttaaatcat     1320

ctcagtcctt atggcagttt tattttcctg tagttggaac tactaaaatt taggaaaatg     1380

ctaagttcaa gtttcgtaat gctttgaagt atttttatgc tctgaatgtt taaatgttct     1440

catcagtttc ttgccatgtt gttaactata caacctggct aaagatgaat atttttctac     1500

tggtatttta atttttgacc taaatgttta agcattcgga atgagaaaac tatacagatt     1560

tgagaaatga tgctaaattt ataggagttt tcagtaactt aaaaagctaa catgagagca     1620

tgccaaaatt tgctaagtct tacaaagatc aagggctgtc cgcaacaggg aagaacagtt     1680

ttgaaaattt atgaactatc ttatttttag gtaggttttg aaagcttttt gtctaagtga     1740

attcttatgc cttggtcaga gtaataactg aaggagttgc ttatcttggc tttcgagtct     1800

gagtttaaaa ctacacattt tgacatagtg tttattagca gccatctaaa aaggctctaa     1860

tgtatattta actaaaatta ctagctttgg gaattaaact gtttaacaaa taaaaaaaaa     1920

aaa                                                                   1923


<210> 2
<211> 297
<212> PRT
<213> Homo sapiens

<400> 2
Met Glu Asp Tyr Thr Lys Ile Glu Lys Ile Gly Glu Gly Thr Tyr Gly 
1               5                   10                  15      


Val Val Tyr Lys Gly Arg His Lys Thr Thr Gly Gln Val Val Ala Met 
            20                  25                  30          


Lys Lys Ile Arg Leu Glu Ser Glu Glu Glu Gly Val Pro Ser Thr Ala 
        35                  40                  45              


Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu Arg His Pro Asn Ile Val 
    50                  55                  60                  


Ser Leu Gln Asp Val Leu Met Gln Asp Ser Arg Leu Tyr Leu Ile Phe 
65                  70                  75                  80  


Glu Phe Leu Ser Met Asp Leu Lys Lys Tyr Leu Asp Ser Ile Pro Pro 
                85                  90                  95      


Gly Gln Tyr Met Asp Ser Ser Leu Val Lys Ser Tyr Leu Tyr Gln Ile 
            100                 105                 110         


Leu Gln Gly Ile Val Phe Cys His Ser Arg Arg Val Leu His Arg Asp 
        115                 120                 125             


Leu Lys Pro Gln Asn Leu Leu Ile Asp Asp Lys Gly Thr Ile Lys Leu 
    130                 135                 140                 


Ala Asp Phe Gly Leu Ala Arg Ala Phe Gly Ile Pro Ile Arg Val Tyr 
145                 150                 155                 160 


Thr His Glu Val Val Thr Leu Trp Tyr Arg Ser Pro Glu Val Leu Leu 
                165                 170                 175     


Gly Ser Ala Arg Tyr Ser Thr Pro Val Asp Ile Trp Ser Ile Gly Thr 
            180                 185                 190         


Ile Phe Ala Glu Leu Ala Thr Lys Lys Pro Leu Phe His Gly Asp Ser 
        195                 200                 205             


Glu Ile Asp Gln Leu Phe Arg Ile Phe Arg Ala Leu Gly Thr Pro Asn 
    210                 215                 220                 


Asn Glu Val Trp Pro Glu Val Glu Ser Leu Gln Asp Tyr Lys Asn Thr 
225                 230                 235                 240 


Phe Pro Lys Trp Lys Pro Gly Ser Leu Ala Ser His Val Lys Asn Leu 
                245                 250                 255     


Asp Glu Asn Gly Leu Asp Leu Leu Ser Lys Met Leu Ile Tyr Asp Pro 
            260                 265                 270         


Ala Lys Arg Ile Ser Gly Lys Met Ala Leu Asn His Pro Tyr Phe Asn 
        275                 280                 285             


Asp Leu Asp Asn Gln Ile Lys Lys Met 
    290                 295         


<210> 3
<211> 2177
<212> DNA
<213> Homo sapiens

<400> 3
cgaacgcctt cgcgcgatcg ccctggaaac gcattctctg cgaccggcag ccgccaatgg       60

gaagggagtg agtgccacga acaggccaat aaggagggag cagtgcgggg tttaaatctg      120

aggctaggct ggctcttctc ggcgtgctgc ggcggaacgg ctgttggttt ctgctgggtg      180

taggtccttg gctggtcggg cctccggtgt tctgcttctc cccgctgagc tgctgcctgg      240

tgaagaggaa gccatggcgc tccgagtcac caggaactcg aaaattaatg ctgaaaataa      300

ggcgaagatc aacatggcag gcgcaaagcg cgttcctacg gcccctgctg caacctccaa      360

gcccggactg aggccaagaa cagctcttgg ggacattggt aacaaagtca gtgaacaact      420

gcaggccaaa atgcctatga agaaggaagc aaaaccttca gctactggaa aagtcattga      480

taaaaaacta ccaaaacctc ttgaaaaggt acctatgctg gtgccagtgc cagtgtctga      540

gccagtgcca gagccagaac ctgagccaga acctgagcct gttaaagaag aaaaactttc      600

gcctgagcct attttggttg atactgcctc tccaagccca atggaaacat ctggatgtgc      660

ccctgcagaa gaagacctgt gtcaggcttt ctctgatgta attcttgcag taaatgatgt      720

ggatgcagaa gatggagctg atccaaacct ttgtagtgaa tatgtgaaag atatttatgc      780

ttatctgaga caacttgagg aagagcaagc agtcagacca aaatacctac tgggtcggga      840

agtcactgga aacatgagag ccatcctaat tgactggcta gtacaggttc aaatgaaatt      900

caggttgttg caggagacca tgtacatgac tgtctccatt attgatcggt tcatgcagaa      960

taattgtgtg cccaagaaga tgctgcagct ggttggtgtc actgccatgt ttattgcaag     1020

caaatatgaa gaaatgtacc ctccagaaat tggtgacttt gcttttgtga ctgacaacac     1080

ttatactaag caccaaatca gacagatgga aatgaagatt ctaagagctt taaactttgg     1140

tctgggtcgg cctctacctt tgcacttcct tcggagagca tctaagattg gagaggttga     1200

tgtcgagcaa catactttgg ccaaatacct gatggaacta actatgttgg actatgacat     1260

ggtgcacttt cctccttctc aaattgcagc aggagctttt tgcttagcac tgaaaattct     1320

ggataatggt gaatggacac caactctaca acattacctg tcatatactg aagaatctct     1380

tcttccagtt atgcagcacc tggctaagaa tgtagtcatg gtaaatcaag gacttacaaa     1440

gcacatgact gtcaagaaca agtatgccac atcgaagcat gctaagatca gcactctacc     1500

acagctgaat tctgcactag ttcaagattt agccaaggct gtggcaaagg tgtaacttgt     1560

aaacttgagt tggagtacta tatttacaaa taaaattggc accatgtgcc atctgtacat     1620

attactgttg catttacttt taataaagct tgtggcccct tttacttttt tatagcttaa     1680

ctaatttgaa tgtggttact tcctactgta gggtagcgga aaagttgtct taaaaggtat     1740

ggtggggata tttttaaaaa ctccttttgg tttacctggg gatccaattg atgtatatgt     1800

ttatatactg ggttcttgtt ttatatacct ggcttttact ttattaatat gagttactga     1860

aggtgatgga ggtatttgaa aattttactt ccataggaca tactgcatgt aagccaagtc     1920

atggagaatc tgctgcatag ctctatttta aagtaaaagt ctaccaccga atccctagtc     1980

cccctgtttt ctgtttcttc ttgtgattgc tgccataatt ctaagttatt tacttttacc     2040

actatttaag ttatcaactt tagctagtat cttcaaactt tcactttgaa aaatgagaat     2100

tttatattct aagccagttt tcattttggt tttgtgtttt ggttaataaa acaatactca     2160

aatacaaaaa aaaaaaa                                                    2177


<210> 4
<211> 433
<212> PRT
<213> Homo sapiens

<400> 4
Met Ala Leu Arg Val Thr Arg Asn Ser Lys Ile Asn Ala Glu Asn Lys 
1               5                   10                  15      


Ala Lys Ile Asn Met Ala Gly Ala Lys Arg Val Pro Thr Ala Pro Ala 
            20                  25                  30          


Ala Thr Ser Lys Pro Gly Leu Arg Pro Arg Thr Ala Leu Gly Asp Ile 
        35                  40                  45              


Gly Asn Lys Val Ser Glu Gln Leu Gln Ala Lys Met Pro Met Lys Lys 
    50                  55                  60                  


Glu Ala Lys Pro Ser Ala Thr Gly Lys Val Ile Asp Lys Lys Leu Pro 
65                  70                  75                  80  


Lys Pro Leu Glu Lys Val Pro Met Leu Val Pro Val Pro Val Ser Glu 
                85                  90                  95      


Pro Val Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Val Lys Glu 
            100                 105                 110         


Glu Lys Leu Ser Pro Glu Pro Ile Leu Val Asp Thr Ala Ser Pro Ser 
        115                 120                 125             


Pro Met Glu Thr Ser Gly Cys Ala Pro Ala Glu Glu Asp Leu Cys Gln 
    130                 135                 140                 


Ala Phe Ser Asp Val Ile Leu Ala Val Asn Asp Val Asp Ala Glu Asp 
145                 150                 155                 160 


Gly Ala Asp Pro Asn Leu Cys Ser Glu Tyr Val Lys Asp Ile Tyr Ala 
                165                 170                 175     


Tyr Leu Arg Gln Leu Glu Glu Glu Gln Ala Val Arg Pro Lys Tyr Leu 
            180                 185                 190         


Leu Gly Arg Glu Val Thr Gly Asn Met Arg Ala Ile Leu Ile Asp Trp 
        195                 200                 205             


Leu Val Gln Val Gln Met Lys Phe Arg Leu Leu Gln Glu Thr Met Tyr 
    210                 215                 220                 


Met Thr Val Ser Ile Ile Asp Arg Phe Met Gln Asn Asn Cys Val Pro 
225                 230                 235                 240 


Lys Lys Met Leu Gln Leu Val Gly Val Thr Ala Met Phe Ile Ala Ser 
                245                 250                 255     


Lys Tyr Glu Glu Met Tyr Pro Pro Glu Ile Gly Asp Phe Ala Phe Val 
            260                 265                 270         


Thr Asp Asn Thr Tyr Thr Lys His Gln Ile Arg Gln Met Glu Met Lys 
        275                 280                 285             


Ile Leu Arg Ala Leu Asn Phe Gly Leu Gly Arg Pro Leu Pro Leu His 
    290                 295                 300                 


Phe Leu Arg Arg Ala Ser Lys Ile Gly Glu Val Asp Val Glu Gln His 
305                 310                 315                 320 


Thr Leu Ala Lys Tyr Leu Met Glu Leu Thr Met Leu Asp Tyr Asp Met 
                325                 330                 335     


Val His Phe Pro Pro Ser Gln Ile Ala Ala Gly Ala Phe Cys Leu Ala 
            340                 345                 350         


Leu Lys Ile Leu Asp Asn Gly Glu Trp Thr Pro Thr Leu Gln His Tyr 
        355                 360                 365             


Leu Ser Tyr Thr Glu Glu Ser Leu Leu Pro Val Met Gln His Leu Ala 
    370                 375                 380                 


Lys Asn Val Val Met Val Asn Gln Gly Leu Thr Lys His Met Thr Val 
385                 390                 395                 400 


Lys Asn Lys Tyr Ala Thr Ser Lys His Ala Lys Ile Ser Thr Leu Pro 
                405                 410                 415     


Gln Leu Asn Ser Ala Leu Val Gln Asp Leu Ala Lys Ala Val Ala Lys 
            420                 425                 430         


Val 
    


<210> 5
<211> 1314
<212> DNA
<213> Homo sapiens

<400> 5
cggggcggga gatttgaaaa gtccttggcc agggcgcggc gtggcagatt cagttgtttg       60

cgggcggccg ggagagtagc agtgccttgg accccagctc tcctccccct ttctctctaa      120

ggatggccca gaaggagaac tcctacccct ggccctacgg ccgacagacg gctccatctg      180

gcctgagcac cctgccccag cgagtcctcc ggaaagagcc tgtcacccca tctgcacttg      240

tcctcatgag ccgctccaat gtccagccca cagctgcccc tggccagaag gtgatggaga      300

atagcagtgg gacacccgac atcttaacgc ggcacttcac aattgatgac tttgagattg      360

ggcgtcctct gggcaaaggc aagtttggaa acgtgtactt ggctcgggag aagaaaagcc      420

atttcatcgt ggcgctcaag gtcctcttca agtcccagat agagaaggag ggcgtggagc      480

atcagctgcg cagagagatc gaaatccagg cccacctgca ccatcccaac atcctgcgtc      540

tctacaacta tttttatgac cggaggagga tctacttgat tctagagtat gccccccgcg      600

gggagctcta caaggagctg cagaagagct gcacatttga cgagcagcga acagccacga      660

tcatggagga gttggcagat gctctaatgt actgccatgg gaagaaggtg attcacagag      720

acataaagcc agaaaatctg ctcttagggc tcaagggaga gctgaagatt gctgacttcg      780

gctggtctgt gcatgcgccc tccctgagga ggaagacaat gtgtggcacc ctggactacc      840

tgcccccaga gatgattgag gggcgcatgc acaatgagaa ggtggatctg tggtgcattg      900

gagtgctttg ctatgagctg ctggtgggga acccaccctt tgagagtgca tcacacaacg      960

agacctatcg ccgcatcgtc aaggtggacc taaagttccc cgcttccgtg cccatgggag     1020

cccaggacct catctccaaa ctgctcaggc ataacccctc ggaacggctg cccctggccc     1080

aggtctcagc ccacccttgg gtccgggcca actctcggag ggtgctgcct ccctctgccc     1140

ttcaatctgt cgcctgatgg tccctgtcat tcactcgggt gcgtgtgttt gtatgtctgt     1200

gtatgtatag gggaaagaag ggatccctaa ctgttccctt atctgttttc tacctcctcc     1260

tttgtttaat aaaggctgaa gctttttgta ctcatgaaaa aaaaaaaaaa aaaa           1314


<210> 6
<211> 344
<212> PRT
<213> Homo sapiens

<400> 6
Met Ala Gln Lys Glu Asn Ser Tyr Pro Trp Pro Tyr Gly Arg Gln Thr 
1               5                   10                  15      


Ala Pro Ser Gly Leu Ser Thr Leu Pro Gln Arg Val Leu Arg Lys Glu 
            20                  25                  30          


Pro Val Thr Pro Ser Ala Leu Val Leu Met Ser Arg Ser Asn Val Gln 
        35                  40                  45              


Pro Thr Ala Ala Pro Gly Gln Lys Val Met Glu Asn Ser Ser Gly Thr 
    50                  55                  60                  


Pro Asp Ile Leu Thr Arg His Phe Thr Ile Asp Asp Phe Glu Ile Gly 
65                  70                  75                  80  


Arg Pro Leu Gly Lys Gly Lys Phe Gly Asn Val Tyr Leu Ala Arg Glu 
                85                  90                  95      


Lys Lys Ser His Phe Ile Val Ala Leu Lys Val Leu Phe Lys Ser Gln 
            100                 105                 110         


Ile Glu Lys Glu Gly Val Glu His Gln Leu Arg Arg Glu Ile Glu Ile 
        115                 120                 125             


Gln Ala His Leu His His Pro Asn Ile Leu Arg Leu Tyr Asn Tyr Phe 
    130                 135                 140                 


Tyr Asp Arg Arg Arg Ile Tyr Leu Ile Leu Glu Tyr Ala Pro Arg Gly 
145                 150                 155                 160 


Glu Leu Tyr Lys Glu Leu Gln Lys Ser Cys Thr Phe Asp Glu Gln Arg 
                165                 170                 175     


Thr Ala Thr Ile Met Glu Glu Leu Ala Asp Ala Leu Met Tyr Cys His 
            180                 185                 190         


Gly Lys Lys Val Ile His Arg Asp Ile Lys Pro Glu Asn Leu Leu Leu 
        195                 200                 205             


Gly Leu Lys Gly Glu Leu Lys Ile Ala Asp Phe Gly Trp Ser Val His 
    210                 215                 220                 


Ala Pro Ser Leu Arg Arg Lys Thr Met Cys Gly Thr Leu Asp Tyr Leu 
225                 230                 235                 240 


Pro Pro Glu Met Ile Glu Gly Arg Met His Asn Glu Lys Val Asp Leu 
                245                 250                 255     


Trp Cys Ile Gly Val Leu Cys Tyr Glu Leu Leu Val Gly Asn Pro Pro 
            260                 265                 270         


Phe Glu Ser Ala Ser His Asn Glu Thr Tyr Arg Arg Ile Val Lys Val 
        275                 280                 285             


Asp Leu Lys Phe Pro Ala Ser Val Pro Met Gly Ala Gln Asp Leu Ile 
    290                 295                 300                 


Ser Lys Leu Leu Arg His Asn Pro Ser Glu Arg Leu Pro Leu Ala Gln 
305                 310                 315                 320 


Val Ser Ala His Pro Trp Val Arg Ala Asn Ser Arg Arg Val Leu Pro 
                325                 330                 335     


Pro Ser Ala Leu Gln Ser Val Ala 
            340                 


<210> 7
<211> 2860
<212> DNA
<213> Mus musculus

<400> 7
actcggcctc taagctcctg gagttgctgc gtccgcgcag tccggaactg cggtgtggcc       60

ccagccggga cagagagggt ccgtcgtaac ctgttgagta actatggaag actatatcaa      120

aatagagaaa attggagaag gtacttacgg tgtggtgtat aagggtagac acagagtcac      180

tggccagata gtggccatga agaagatcag acttgaaagc gaggaagaag gagtgcccag      240

tactgcaatt cgggaaatct ctctattaaa agaacttcga catccaaata tagtcagcct      300

gcaggatgtg ctcatgcagg actccaggct gtatctcatc tttgagttcc tgtccatgga      360

cctcaagaag tacctggact ccatccctcc tgggcagttc atggattctt cactcgttaa      420

gagttactta caccaaatcc tccagggaat tgtgttttgc cactcccggc gagttcttca      480

cagagacttg aaacctcaaa atctattgat tgatgacaaa ggaacaatca aactggctga      540

tttcggcctt gccagagcgt ttggaatacc gatacgagtg tacacacacg aggtagtgac      600

gctgtggtac cgatctccag aagtgttgct gggctcggct cgttactcca ctccggttga      660

catctggagt atagggacca tatttgcaga actggccacc aagaagccgc ttttccacgg      720

cgactcagag attgaccagc tcttcaggat cttcagagct ctgggcactc ctaacaacga      780

agtgtggcca gaagtcgagt ccctgcagga ctacaagaac acctttccca agtggaagcc      840

ggggagcctc gcatcccacg tcaagaacct ggacgagaac ggcttggatt tgctctcaaa      900

aatgctagtc tatgatcctg ccaaacgaat ctctggcaaa atggccctga agcacccgta      960

ctttgatgac ttggacaatc agattaagaa gatgtagccc tctggatgga tgtccctgtc     1020

tgctggtcgt aggggaagat cgtgttgttt accgttggct ctcttcctgt cttgtatagt     1080

tttctttgtt tgtaaactgt catctggact tttcttaatt tcctacgtat aacttaatta     1140

acatgtaaat attattccat atgaatttaa atataattct gtatatgtgc agatgtcact     1200

gtggtggctg ttaattacta taacacaagt gttaattact acaacataag acttgagtct     1260

ccctagactt cccagcagcc attcctgcag ctcggagcac agttgaagga gctgagctca     1320

ggcctcgtga tgctttcaag tgcctccgtg ttctggatat atatgattcc tggtcagttt     1380

cttgccattt ggaaactaca acccacctac ggacagtgtt tttctacttg tgcttaagca     1440

gttgggatga gaaggccaaa gacccgagga tgtctagagt aatgaccccc agatggaagt     1500

gcaccaaagc tggctgggtt tcacagctag agatcagggg ctgtccagag caggacagct     1560

tagaacattt atgaagactc cctattttta ggtttgttgt aaagctgttg tctagttgga     1620

ttcctgtgct ctgcatggtc agaggtaggt tagaggattt gccttggctt ctaaatccaa     1680

tttgaaaact gcttaaaatc tcctgtcctc tcttagcagt gtctaaaaat gtccttgtcc     1740

aaatatttag ctgagattcc tcactttgga aaaggagccg tatcgctgtg ctgcttagtg     1800

taattcttag aagcagcctg acttatctgc tagcagtcaa agggatgcct gagacgactg     1860

ctcctcttag aactaaaggc tgggatgctt aagtttgtct actgtttgga ggatctcggt     1920

aagactgagc ccctgttcct gtggccacct cagtttacca gtacctcagc ctcagcctcc     1980

tgcatttgct ggagtcaggg aaggtcccca gccctgagcc ctgacgctcc tgattgtaga     2040

gactgtcagt tggaggtaaa acgttcattg aagtagtcag cagccacatg catttagggc     2100

actccagtgt cagagaccat cctggaggtt tctaaccctg ccgctggcag tctactccca     2160

agacagatca gttagagtgg tcagcaaaca ccaactgctg cagaaacctg tgttggtgtg     2220

gttccctgct gctgctggga actgggccca agactagaga gcttggggct gcggttgatc     2280

atgggttctg ttcctgcatt acaccttgaa atccaagcct tctaatatct cccttcggat     2340

cataagttgt gaatttggtc ctccgccccc gccaggtttt ctatacttgg gtttgtcttg     2400

ctgacatttt caagagtcct gactaagacg gtgattagtg tgacatgact tgagaactac     2460

cgatttgaag cacacttgaa gttaacaaat tctctcatga ttatactttt aactttttat     2520

aagattgctt gagctcaccc agatctctgt tgggaagtaa ctgggtaaca aaagccgttg     2580

cactggtttg acagctaaca actgttggta ctttgtattc agaaggaatg aggtagcgat     2640

tgaatggctg gggtgttgtt tccacagttt atacactaaa aatttgggta gccaggaggt     2700

agtggcgcgc aatctttaat ctcagcagag gcagtcctat ctcttgagtt ggaggccagc     2760

ctgcctgagt tccagaccag ccagggctac aggaagaagt cttaaaaaaa ttttttttcc     2820

ctgtggatgt aaacccatga gaatgactgc tgtatctatc                           2860


<210> 8
<211> 297
<212> PRT
<213> Mus musculus

<400> 8
Met Glu Asp Tyr Ile Lys Ile Glu Lys Ile Gly Glu Gly Thr Tyr Gly 
1               5                   10                  15      


Val Val Tyr Lys Gly Arg His Arg Val Thr Gly Gln Ile Val Ala Met 
            20                  25                  30          


Lys Lys Ile Arg Leu Glu Ser Glu Glu Glu Gly Val Pro Ser Thr Ala 
        35                  40                  45              


Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu Arg His Pro Asn Ile Val 
    50                  55                  60                  


Ser Leu Gln Asp Val Leu Met Gln Asp Ser Arg Leu Tyr Leu Ile Phe 
65                  70                  75                  80  


Glu Phe Leu Ser Met Asp Leu Lys Lys Tyr Leu Asp Ser Ile Pro Pro 
                85                  90                  95      


Gly Gln Phe Met Asp Ser Ser Leu Val Lys Ser Tyr Leu His Gln Ile 
            100                 105                 110         


Leu Gln Gly Ile Val Phe Cys His Ser Arg Arg Val Leu His Arg Asp 
        115                 120                 125             


Leu Lys Pro Gln Asn Leu Leu Ile Asp Asp Lys Gly Thr Ile Lys Leu 
    130                 135                 140                 


Ala Asp Phe Gly Leu Ala Arg Ala Phe Gly Ile Pro Ile Arg Val Tyr 
145                 150                 155                 160 


Thr His Glu Val Val Thr Leu Trp Tyr Arg Ser Pro Glu Val Leu Leu 
                165                 170                 175     


Gly Ser Ala Arg Tyr Ser Thr Pro Val Asp Ile Trp Ser Ile Gly Thr 
            180                 185                 190         


Ile Phe Ala Glu Leu Ala Thr Lys Lys Pro Leu Phe His Gly Asp Ser 
        195                 200                 205             


Glu Ile Asp Gln Leu Phe Arg Ile Phe Arg Ala Leu Gly Thr Pro Asn 
    210                 215                 220                 


Asn Glu Val Trp Pro Glu Val Glu Ser Leu Gln Asp Tyr Lys Asn Thr 
225                 230                 235                 240 


Phe Pro Lys Trp Lys Pro Gly Ser Leu Ala Ser His Val Lys Asn Leu 
                245                 250                 255     


Asp Glu Asn Gly Leu Asp Leu Leu Ser Lys Met Leu Val Tyr Asp Pro 
            260                 265                 270         


Ala Lys Arg Ile Ser Gly Lys Met Ala Leu Lys His Pro Tyr Phe Asp 
        275                 280                 285             


Asp Leu Asp Asn Gln Ile Lys Lys Met 
    290                 295         


<210> 9
<211> 2316
<212> DNA
<213> Mus musculus

<400> 9
ggaacggctg ttagtgttta gctgtggata gccagaggtt agggtgtctt ctcgaatcgg       60

ggaacctctg attttggagg agccatggcg ctcagggtca ctaggaacac gaaaattaac      120

gcagaaaata aggccaaggt cagtatggca ggcgccaagc gtgtgcctgt gacagttact      180

gctgcttcca agcccgggct gagaccgaga actgctcttg gagacattgg taataaagtc      240

agcgaagagc tacaggcaag agtgcctctg aaaagggaag caaaaacgct aggtactgga      300

aaaggtactg ttaaagccct accaaaacct gtagagaagg tgcctgtgtg tgaaccagag      360

gtggaacttg ctgagcctga gcctgaacct gaacttgaac atgttagaga agagaagctt      420

tctcctgaac ctattttggt tgataatccc tctccaagcc cgatggaaac atctggatgt      480

gcgcctgcag aagagtatct gtgtcaggct ttctctgatg taatccttgc agtgagtgac      540

gtagacgcag atgatggggc tgacccaaac ctctgtagtg aatatgtgaa agatatctat      600

gcttatctcc gacaactgga ggaagagcag tcagttagac caaaatacct acagggtcgt      660

gaagtgactg gaaacatgag agctatcctc attgactggc taatacaggt tcagatgaaa      720

tttaggctgc ttcaggagac catgtacatg actgtgtcca ttattgatcg gttcatgcag      780

aacagttgtg tgcccaagaa gatgctacag ctggtcggtg taacggccat gtttattgca      840

agcaaatatg aggagatgta ccctccagaa ataggtgact tcgcctttgt gactaacaac      900

acgtacacta agcaccagat cagacagatg gagatgaaga ttctcagagt tctgaacttc      960

agcctgggtc gccctctgcc tctgcacttc ctccgtagag catctaaagt cggagaggtt     1020

gacgtcgagc agcacacttt ggccaaatac ctcatggagc tctccatgct ggactacgac     1080

atggtgcatt ttgctccttc tcaaattgca gctggggctt tctgcttagc gctgaaaatt     1140

cttgacaacg gtgaatggac accaactctg cagcactacc tatcctacag tgaagactcc     1200

ctgcttcctg ttatgcagca cctggctaag aatgtagtca tggtgaactg tggcctcaca     1260

aagcacatga ctgtcaagaa caagtatgca gcatctaagc atgctaagat cagcacgctg     1320

gcacagctga actgtacact agttcagaat ttgtctaagg ccgtgacaaa ggcataactc     1380

caatagactg ctacatctgc agatgcagtt ggcaccatgt gccgcctgta cataggatac     1440

ctaccgtgtt tacttgctct tcaataaagg ttgtgacttc tcattttaca tagcttaact     1500

catttgaatg ttgttgcttc tgagtttagg ctaacggaag ttgtcgaatt taggagtata     1560

ttaaaaactg catctagttt taacagtgga tccaactaat gtatatatct gtagcctata     1620

tgtctatata catccttcac tgtgtgtcct tatatcatca tgtcttctgc ctcactctag     1680

tttaaactct aaatctacca gctagtcctt tgttccattt tccagtggtt gccaccttta     1740

accactgtct cttggtttgt caactttcag atctgaaacc aagtatcttt ttttatgtaa     1800

ttatttattt gttcttaatt ggaaaatagg atgttcaaaa ttaaaggtgt gttttaaaaa     1860

gaatttgccc ccaagtctca ctatcaacag ataagggtgt attcttgtat atcctgtata     1920

gatataatca tgcatatact cccaaggaga tatttttata tgggttcatt ttatcaacag     1980

tattcctatc agcattcctt tcaatgccta tattgcattt cctagtgtga acaaactgtg     2040

tgtaacatag tcattccctc ggtgggattc aagtgcattc tctcagtgcc ctccacagtg     2100

ttcttaaatg atgtttaatg tcttgcttgg cttcattcat agtagctctt ccaggggtgt     2160

gctttgaatt ctgacagcca gatgggtgtg gctgccacca taccaaggcg ccactcctgt     2220

cttgtaatgc cacctggaaa agaatcctgt ctcatttgct gttttaattt atacatctga     2280

tatcaagttg aataaaattt attggtggaa agcttt                               2316


<210> 10
<211> 430
<212> PRT
<213> Mus musculus

<400> 10
Met Ala Leu Arg Val Thr Arg Asn Thr Lys Ile Asn Ala Glu Asn Lys 
1               5                   10                  15      


Ala Lys Val Ser Met Ala Gly Ala Lys Arg Val Pro Val Thr Val Thr 
            20                  25                  30          


Ala Ala Ser Lys Pro Gly Leu Arg Pro Arg Thr Ala Leu Gly Asp Ile 
        35                  40                  45              


Gly Asn Lys Val Ser Glu Glu Leu Gln Ala Arg Val Pro Leu Lys Arg 
    50                  55                  60                  


Glu Ala Lys Thr Leu Gly Thr Gly Lys Gly Thr Val Lys Ala Leu Pro 
65                  70                  75                  80  


Lys Pro Val Glu Lys Val Pro Val Cys Glu Pro Glu Val Glu Leu Ala 
                85                  90                  95      


Glu Pro Glu Pro Glu Pro Glu Leu Glu His Val Arg Glu Glu Lys Leu 
            100                 105                 110         


Ser Pro Glu Pro Ile Leu Val Asp Asn Pro Ser Pro Ser Pro Met Glu 
        115                 120                 125             


Thr Ser Gly Cys Ala Pro Ala Glu Glu Tyr Leu Cys Gln Ala Phe Ser 
    130                 135                 140                 


Asp Val Ile Leu Ala Val Ser Asp Val Asp Ala Asp Asp Gly Ala Asp 
145                 150                 155                 160 


Pro Asn Leu Cys Ser Glu Tyr Val Lys Asp Ile Tyr Ala Tyr Leu Arg 
                165                 170                 175     


Gln Leu Glu Glu Glu Gln Ser Val Arg Pro Lys Tyr Leu Gln Gly Arg 
            180                 185                 190         


Glu Val Thr Gly Asn Met Arg Ala Ile Leu Ile Asp Trp Leu Ile Gln 
        195                 200                 205             


Val Gln Met Lys Phe Arg Leu Leu Gln Glu Thr Met Tyr Met Thr Val 
    210                 215                 220                 


Ser Ile Ile Asp Arg Phe Met Gln Asn Ser Cys Val Pro Lys Lys Met 
225                 230                 235                 240 


Leu Gln Leu Val Gly Val Thr Ala Met Phe Ile Ala Ser Lys Tyr Glu 
                245                 250                 255     


Glu Met Tyr Pro Pro Glu Ile Gly Asp Phe Ala Phe Val Thr Asn Asn 
            260                 265                 270         


Thr Tyr Thr Lys His Gln Ile Arg Gln Met Glu Met Lys Ile Leu Arg 
        275                 280                 285             


Val Leu Asn Phe Ser Leu Gly Arg Pro Leu Pro Leu His Phe Leu Arg 
    290                 295                 300                 


Arg Ala Ser Lys Val Gly Glu Val Asp Val Glu Gln His Thr Leu Ala 
305                 310                 315                 320 


Lys Tyr Leu Met Glu Leu Ser Met Leu Asp Tyr Asp Met Val His Phe 
                325                 330                 335     


Ala Pro Ser Gln Ile Ala Ala Gly Ala Phe Cys Leu Ala Leu Lys Ile 
            340                 345                 350         


Leu Asp Asn Gly Glu Trp Thr Pro Thr Leu Gln His Tyr Leu Ser Tyr 
        355                 360                 365             


Ser Glu Asp Ser Leu Leu Pro Val Met Gln His Leu Ala Lys Asn Val 
    370                 375                 380                 


Val Met Val Asn Cys Gly Leu Thr Lys His Met Thr Val Lys Asn Lys 
385                 390                 395                 400 


Tyr Ala Ala Ser Lys His Ala Lys Ile Ser Thr Leu Ala Gln Leu Asn 
                405                 410                 415     


Cys Thr Leu Val Gln Asn Leu Ser Lys Ala Val Thr Lys Ala 
            420                 425                 430 


<210> 11
<211> 1957
<212> DNA
<213> Mus musculus

<400> 11
ggagattcga aagcgtccgg gtcgcggggt aaaccggttc tccgtgtgcg agcgcctagt       60

ggcgtaggct gcggctttgc ggggaactgc gggggctgca gtggtccacg gggctgatcg      120

ggttccgttg ggcggatcca cgtgcccgct atccgcctgg aaggagaggt gcaggagtac      180

ccccgacctt ggctgcgtgc tgactcgctt ccttctgccc gcccaggctt gcactccccg      240

gggatctgcc tctgcatctc ttgccttcgc tgttgtttcc ctctctgtcc agctcccctc      300

ccgctctcgc cctggagaat ggctcagaag gagaacgcct acccgtggcc ctacggctca      360

aagacgtctc agtctggcct gaacacgttg tcccagagag tcctacggaa ggagcccgcc      420

acgacatctg cgcttgctct cgtgaaccgg ttcaacagcc agtccacagc tgcccctggc      480

cagaagttgg ctgagaacaa gagtcagggc tccactgcct cgcaaggatc ccagaacaag      540

cagcctttca ctattgacaa ctttgagatt gggcgtcctt tgggcaaagg caaatttgga      600

aacgtgtact tggctcggga gaagaagagc cgtttcatcg tggcactcaa gatcctcttc      660

aagtctcaga ttgagaagga gggggtagag caccagcttc gccgagagat cgaaatccag      720

gcgcacctga aacatcccaa catccttcaa ctctacaact acttctacga ccagcagagg      780

atctacttaa tcctggaata cgcccctcgc ggggaactct acaaggaact gcagaagagt      840

cggaccttcg atgagcagcg gactgccacg atcatggagg aactgtcaga tgccctgacc      900

tactgccaca agaagaaggt aattcacaga gacataaagc cggagaacct gctgttaggt      960

ctgcagggag aactgaagat tgcagacttt ggctggtcgg tgcatgcccc atccctgagg     1020

aggaagacca tgtgcggcac gctggactat ctgcccccag agatgattga ggggcgcatg     1080

cataatgaaa tggtagatct atggtgcatc ggggtgctct gctatgaact gatggtgggg     1140

aacccaccct tcgagagccc tagccacagt gagacgtatc gtcggattgt caaggtggac     1200

ctgaagttcc cctcttctgt gccttcgggc gcccaggacc tcatctccaa gctgctcaaa     1260

cataacccct ggcaacggct gcccctggcg gaggttgcag ctcacccttg ggtccgggcc     1320

aactcaagga gggttctgcc tccctctgcc ctttagcctg ctccttggtt ttttgtccct     1380

gtcatttttc agtgttcttt gtatgtctgt gtatgtgttc tgagaagggg tgggaactgg     1440

aaactattcc tagctccagt tctaggggat ctgatctctc ttctgacctc tacaggcaaa     1500

attaggcacc cctgtggtgc acatatatgc acaccaaaca catgaagtta caaacaaaca     1560

acaaacacac agatagtgct ggagagatgg ctcggtagtt aaaagcactg gctgctcttc     1620

ccaggaacct agaactcaat tctagcacta catggtgctc acgaccactg tctgtaacac     1680

ccagtcctgg ggaatctggg gccttcgagc ctctgcagac actaggcatg gatgtggtat     1740

acatgtatgc aggcaaaaca cccatgcact gacttttaag aaaccctcta gtctgattcc     1800

tttcaatttg tcaaatgttg aatgttattt ttaaaatatt ataagccatt taatacaatt     1860

tttctttgaa acatggtata gcctagtctg tcttaaattc agaaaaatta tgaagaacaa     1920

cattttataa taaagtctta aatgtttcat gtttttg                              1957


<210> 12
<211> 345
<212> PRT
<213> Mus musculus

<400> 12
Met Ala Gln Lys Glu Asn Ala Tyr Pro Trp Pro Tyr Gly Ser Lys Thr 
1               5                   10                  15      


Ser Gln Ser Gly Leu Asn Thr Leu Ser Gln Arg Val Leu Arg Lys Glu 
            20                  25                  30          


Pro Ala Thr Thr Ser Ala Leu Ala Leu Val Asn Arg Phe Asn Ser Gln 
        35                  40                  45              


Ser Thr Ala Ala Pro Gly Gln Lys Leu Ala Glu Asn Lys Ser Gln Gly 
    50                  55                  60                  


Ser Thr Ala Ser Gln Gly Ser Gln Asn Lys Gln Pro Phe Thr Ile Asp 
65                  70                  75                  80  


Asn Phe Glu Ile Gly Arg Pro Leu Gly Lys Gly Lys Phe Gly Asn Val 
                85                  90                  95      


Tyr Leu Ala Arg Glu Lys Lys Ser Arg Phe Ile Val Ala Leu Lys Ile 
            100                 105                 110         


Leu Phe Lys Ser Gln Ile Glu Lys Glu Gly Val Glu His Gln Leu Arg 
        115                 120                 125             


Arg Glu Ile Glu Ile Gln Ala His Leu Lys His Pro Asn Ile Leu Gln 
    130                 135                 140                 


Leu Tyr Asn Tyr Phe Tyr Asp Gln Gln Arg Ile Tyr Leu Ile Leu Glu 
145                 150                 155                 160 


Tyr Ala Pro Arg Gly Glu Leu Tyr Lys Glu Leu Gln Lys Ser Arg Thr 
                165                 170                 175     


Phe Asp Glu Gln Arg Thr Ala Thr Ile Met Glu Glu Leu Ser Asp Ala 
            180                 185                 190         


Leu Thr Tyr Cys His Lys Lys Lys Val Ile His Arg Asp Ile Lys Pro 
        195                 200                 205             


Glu Asn Leu Leu Leu Gly Leu Gln Gly Glu Leu Lys Ile Ala Asp Phe 
    210                 215                 220                 


Gly Trp Ser Val His Ala Pro Ser Leu Arg Arg Lys Thr Met Cys Gly 
225                 230                 235                 240 


Thr Leu Asp Tyr Leu Pro Pro Glu Met Ile Glu Gly Arg Met His Asn 
                245                 250                 255     


Glu Met Val Asp Leu Trp Cys Ile Gly Val Leu Cys Tyr Glu Leu Met 
            260                 265                 270         


Val Gly Asn Pro Pro Phe Glu Ser Pro Ser His Ser Glu Thr Tyr Arg 
        275                 280                 285             


Arg Ile Val Lys Val Asp Leu Lys Phe Pro Ser Ser Val Pro Ser Gly 
    290                 295                 300                 


Ala Gln Asp Leu Ile Ser Lys Leu Leu Lys His Asn Pro Trp Gln Arg 
305                 310                 315                 320 


Leu Pro Leu Ala Glu Val Ala Ala His Pro Trp Val Arg Ala Asn Ser 
                325                 330                 335     


Arg Arg Val Leu Pro Pro Ser Ala Leu 
            340                 345 


<210> 13
<211> 1041
<212> DNA
<213> Homo sapiens

<400> 13
gttcgttgca acaaattgat gagcaatgct tttttataat gccaactttg tacaaaaaag       60

ttggcatggc tacctctcga tatgagccag tggctgaaat tggtgtcggt gcctatggga      120

cagtgtacaa ggcctgtgat ccccacagtg gccactttgt ggccctcaag agtgtgagag      180

tccccaatgg aggaggaggt ggaggaggcc ttcccatcag cacagttcgt gaggtggctt      240

tactgaggcg actggaggct tttgagcatc ccaatgttgt ccggctgatg gacgtctgtg      300

ccacatcccg aactgaccgg gagatcaagg taaccctggt gtttgagcat gtagaccagg      360

acctaaggac atatctggac aaggcacccc caccaggctt gccagccgaa acgatcaagg      420

atctgatgcg ccagtttcta agaggcctag atttccttca tgccaattgc atcgttcacc      480

gagatctgaa gccagagaac attctggtga caagtggtgg aacagtcaag ctggctgact      540

ttggcctggc cagaatctac agctaccaga tggcacttac acccgtggtt gttacactct      600

ggtaccgagc tcccgaagtt cttctgcagt ccacatatgc aacacctgtg gacatgtgga      660

gtgttggctg tatctttgca gagatgtttc gtcgaaagcc tctcttctgt ggaaactctg      720

aagccgacca gttgggcaaa atctttgacc tgattgggct gcctccagag gatgactggc      780

ctcgagatgt atccctgccc cgtggagcct ttccccccag agggccccgc ccagtgcagt      840

cggtggtacc tgagatggag gagtcgggag cacagctgct gctggaaatg ctgactttta      900

acccacacaa gcgaatctct gcctttcgag ctctgcagca ctcttatcta cataaggatg      960

aaggtaatcc ggagtgccca actttcttgt acaaagttgg cattataaga aagcattgct     1020

tatcaatttg ttgcaacgaa c                                               1041


<210> 14
<211> 303
<212> PRT
<213> Homo sapiens

<400> 14
Met Ala Thr Ser Arg Tyr Glu Pro Val Ala Glu Ile Gly Val Gly Ala 
1               5                   10                  15      


Tyr Gly Thr Val Tyr Lys Ala Arg Asp Pro His Ser Gly His Phe Val 
            20                  25                  30          


Ala Leu Lys Ser Val Arg Val Pro Asn Gly Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Leu Pro Ile Ser Thr Val Arg Glu Val Ala Leu Leu Arg Arg Leu Glu 
    50                  55                  60                  


Ala Phe Glu His Pro Asn Val Val Arg Leu Met Asp Val Cys Ala Thr 
65                  70                  75                  80  


Ser Arg Thr Asp Arg Glu Ile Lys Val Thr Leu Val Phe Glu His Val 
                85                  90                  95      


Asp Gln Asp Leu Arg Thr Tyr Leu Asp Lys Ala Pro Pro Pro Gly Leu 
            100                 105                 110         


Pro Ala Glu Thr Ile Lys Asp Leu Met Arg Gln Phe Leu Arg Gly Leu 
        115                 120                 125             


Asp Phe Leu His Ala Asn Cys Ile Val His Arg Asp Leu Lys Pro Glu 
    130                 135                 140                 


Asn Ile Leu Val Thr Ser Gly Gly Thr Val Lys Leu Ala Asp Phe Gly 
145                 150                 155                 160 


Leu Ala Arg Ile Tyr Ser Tyr Gln Met Ala Leu Thr Pro Val Val Val 
                165                 170                 175     


Thr Leu Trp Tyr Arg Ala Pro Glu Val Leu Leu Gln Ser Thr Tyr Ala 
            180                 185                 190         


Thr Pro Val Asp Met Trp Ser Val Gly Cys Ile Phe Ala Glu Met Phe 
        195                 200                 205             


Arg Arg Lys Pro Leu Phe Cys Gly Asn Ser Glu Ala Asp Gln Leu Gly 
    210                 215                 220                 


Lys Ile Phe Asp Leu Ile Gly Leu Pro Pro Glu Asp Asp Trp Pro Arg 
225                 230                 235                 240 


Asp Val Ser Leu Pro Arg Gly Ala Phe Pro Pro Arg Gly Pro Arg Pro 
                245                 250                 255     


Val Gln Ser Val Val Pro Glu Met Glu Glu Ser Gly Ala Gln Leu Leu 
            260                 265                 270         


Leu Glu Met Leu Thr Phe Asn Pro His Lys Arg Ile Ser Ala Phe Arg 
        275                 280                 285             


Ala Leu Gln His Ser Tyr Leu His Lys Asp Glu Gly Asn Pro Glu 
    290                 295                 300             


<210> 15
<211> 4304
<212> DNA
<213> Homo sapiens

<400> 15
cacacggact acaggggagt tttgttgaag ttgcaaagtc ctggagcctc cagagggctg       60

tcggcgcagt agcagcgagc agcagagtcc gcacgctccg gcgaggggca gaagagcgcg      120

agggagcgcg gggcagcaga agcgagagcc gagcgcggac ccagccagga cccacagccc      180

tccccagctg cccaggaaga gccccagcca tggaacacca gctcctgtgc tgcgaagtgg      240

aaaccatccg ccgcgcgtac cccgatgcca acctcctcaa cgaccgggtg ctgcgggcca      300

tgctgaaggc ggaggagacc tgcgcgccct cggtgtccta cttcaaatgt gtgcagaagg      360

aggtcctgcc gtccatgcgg aagatcgtcg ccacctggat gctggaggtc tgcgaggaac      420

agaagtgcga ggaggaggtc ttcccgctgg ccatgaacta cctggaccgc ttcctgtcgc      480

tggagcccgt gaaaaagagc cgcctgcagc tgctgggggc cacttgcatg ttcgtggcct      540

ctaagatgaa ggagaccatc cccctgacgg ccgagaagct gtgcatctac accgacaact      600

ccatccggcc cgaggagctg ctgcaaatgg agctgctcct ggtgaacaag ctcaagtgga      660

acctggccgc aatgaccccg cacgatttca ttgaacactt cctctccaaa atgccagagg      720

cggaggagaa caaacagatc atccgcaaac acgcgcagac cttcgttgcc ctctgtgcca      780

cagatgtgaa gttcatttcc aatccgccct ccatggtggc agcggggagc gtggtggccg      840

cagtgcaagg cctgaacctg aggagcccca acaacttcct gtcctactac cgcctcacac      900

gcttcctctc cagagtgatc aagtgtgacc cggactgcct ccgggcctgc caggagcaga      960

tcgaagccct gctggagtca agcctgcgcc aggcccagca gaacatggac cccaaggccg     1020

ccgaggagga ggaagaggag gaggaggagg tggacctggc ttgcacaccc accgacgtgc     1080

gggacgtgga catctgaggg cgccaggcag gcgggcgcca ccgccacccg cagcgagggc     1140

ggagccggcc ccaggtgctc ccctgacagt ccctcctctc cggagcattt tgataccaga     1200

agggaaagct tcattctcct tgttgttggt tgttttttcc tttgctcttt cccccttcca     1260

tctctgactt aagcaaaaga aaaagattac ccaaaaactg tctttaaaag agagagagag     1320

aaaaaaaaaa tagtatttgc ataaccctga gcggtggggg aggagggttg tgctacagat     1380

gatagaggat tttatacccc aataatcaac tcgtttttat attaatgtac ttgtttctct     1440

gttgtaagaa taggcattaa cacaaaggag gcgtctcggg agaggattag gttccatcct     1500

ttacgtgttt aaaaaaaagc ataaaaacat tttaaaaaca tagaaaaatt cagcaaacca     1560

tttttaaagt agaagagggt tttaggtaga aaaacatatt cttgtgcttt tcctgataaa     1620

gcacagctgt agtggggttc taggcatctc tgtactttgc ttgctcatat gcatgtagtc     1680

actttataag tcattgtatg ttattatatt ccgtaggtag atgtgtaacc tcttcacctt     1740

attcatggct gaagtcacct cttggttaca gtagcgtagc gtgcccgtgt gcatgtcctt     1800

tgcgcctgtg accaccaccc caacaaacca tccagtgaca aaccatccag tggaggtttg     1860

tcgggcacca gccagcgtag cagggtcggg aaaggccacc tgtcccactc ctacgatacg     1920

ctactataaa gagaagacga aatagtgaca taatatattc tatttttata ctcttcctat     1980

ttttgtagtg acctgtttat gagatgctgg ttttctaccc aacggccctg cagccagctc     2040

acgtccaggt tcaacccaca gctacttggt ttgtgttctt cttcatattc taaaaccatt     2100

ccatttccaa gcactttcag tccaataggt gtaggaaata gcgctgtttt tgttgtgtgt     2160

gcagggaggg cagttttcta atggaatggt ttgggaatat ccatgtactt gtttgcaagc     2220

aggactttga ggcaagtgtg ggccactgtg gtggcagtgg aggtggggtg tttgggaggc     2280

tgcgtgccag tcaagaagaa aaaggtttgc attctcacat tgccaggatg ataagttcct     2340

ttccttttct ttaaagaagt tgaagtttag gaatcctttg gtgccaactg gtgtttgaaa     2400

gtagggacct cagaggttta cctagagaac aggtggtttt taagggttat cttagatgtt     2460

tcacaccgga aggtttttaa acactaaaat atataattta tagttaaggc taaaaagtat     2520

atttattgca gaggatgttc ataaggccag tatgatttat aaatgcaatc tccccttgat     2580

ttaaacacac agatacacac acacacacac acacacacaa accttctgcc tttgatgtta     2640

cagatttaat acagtttatt tttaaagata gatcctttta taggtgagaa aaaaacaatc     2700

tggaagaaaa aaaccacaca aagacattga ttcagcctgt ttggcgtttc ccagagtcat     2760

ctgattggac aggcatgggt gcaaggaaaa ttagggtact caacctaagt tcggttccga     2820

tgaattctta tcccctgccc cttcctttaa aaaacttagt gacaaaatag acaatttgca     2880

catcttggct atgtaattct tgtaattttt atttaggaag tgttgaaggg aggtggcaag     2940

agtgtggagg ctgacgtgtg agggaggaca ggcgggagga ggtgtgagga ggaggctccc     3000

gaggggaagg ggcggtgccc acaccgggga caggccgcag ctccattttc ttattgcgct     3060

gctaccgttg acttccaggc acggtttgga aatattcaca tcgcttctgt gtatctcttt     3120

cacattgttt gctgctattg gaggatcagt tttttgtttt acaatgtcat atactgccat     3180

gtactagttt tagttttctc ttagaacatt gtattacaga tgcctttttt gtagtttttt     3240

ttttttttat gtgatcaatt ttgacttaat gtgattactg ctctattcca aaaaggttgc     3300

tgtttcacaa tacctcatgc ttcacttagc catggtggac ccagcgggca ggttctgcct     3360

gctttggcgg gcagacacgc gggcgcgatc ccacacaggc tggcgggggc cggccccgag     3420

gccgcgtgcg tgagaaccgc gccggtgtcc ccagagacca ggctgtgtcc ctcttctctt     3480

ccctgcgcct gtgatgctgg gcacttcatc tgatcggggg cgtagcatca tagtagtttt     3540

tacagctgtg ttattctttg cgtgtagcta tggaagttgc ataattatta ttattattat     3600

tataacaagt gtgtcttacg tgccaccacg gcgttgtacc tgtaggactc tcattcggga     3660

tgattggaat agcttctgga atttgttcaa gttttgggta tgtttaatct gttatgtact     3720

agtgttctgt ttgttattgt tttgttaatt acaccataat gctaatttaa agagactcca     3780

aatctcaatg aagccagctc acagtgctgt gtgccccggt cacctagcaa gctgccgaac     3840

caaaagaatt tgcaccccgc tgcgggccca cgtggttggg gccctgccct ggcagggtca     3900

tcctgtgctc ggaggccatc tcgggcacag gcccaccccg ccccacccct ccagaacacg     3960

gctcacgctt acctcaacca tcctggctgc ggcgtctgtc tgaaccacgc gggggccttg     4020

agggacgctt tgtctgtcgt gatggggcaa gggcacaagt cctggatgtt gtgtgtatcg     4080

agaggccaaa ggctggtggc aagtgcacgg ggcacagcgg agtctgtcct gtgacgcgca     4140

agtctgaggg tctgggcggc gggcggctgg gtctgtgcat ttctggttgc accgcggcgc     4200

ttcccagcac caacatgtaa ccggcatgtt tccagcagaa gacaaaaaga caaacatgaa     4260

agtctagaaa taaaactggt aaaaccccaa aaaaaaaaaa aaaa                      4304


<210> 16
<211> 295
<212> PRT
<213> Homo sapiens

<400> 16
Met Glu His Gln Leu Leu Cys Cys Glu Val Glu Thr Ile Arg Arg Ala 
1               5                   10                  15      


Tyr Pro Asp Ala Asn Leu Leu Asn Asp Arg Val Leu Arg Ala Met Leu 
            20                  25                  30          


Lys Ala Glu Glu Thr Cys Ala Pro Ser Val Ser Tyr Phe Lys Cys Val 
        35                  40                  45              


Gln Lys Glu Val Leu Pro Ser Met Arg Lys Ile Val Ala Thr Trp Met 
    50                  55                  60                  


Leu Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu 
65                  70                  75                  80  


Ala Met Asn Tyr Leu Asp Arg Phe Leu Ser Leu Glu Pro Val Lys Lys 
                85                  90                  95      


Ser Arg Leu Gln Leu Leu Gly Ala Thr Cys Met Phe Val Ala Ser Lys 
            100                 105                 110         


Met Lys Glu Thr Ile Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr 
        115                 120                 125             


Asp Asn Ser Ile Arg Pro Glu Glu Leu Leu Gln Met Glu Leu Leu Leu 
    130                 135                 140                 


Val Asn Lys Leu Lys Trp Asn Leu Ala Ala Met Thr Pro His Asp Phe 
145                 150                 155                 160 


Ile Glu His Phe Leu Ser Lys Met Pro Glu Ala Glu Glu Asn Lys Gln 
                165                 170                 175     


Ile Ile Arg Lys His Ala Gln Thr Phe Val Ala Leu Cys Ala Thr Asp 
            180                 185                 190         


Val Lys Phe Ile Ser Asn Pro Pro Ser Met Val Ala Ala Gly Ser Val 
        195                 200                 205             


Val Ala Ala Val Gln Gly Leu Asn Leu Arg Ser Pro Asn Asn Phe Leu 
    210                 215                 220                 


Ser Tyr Tyr Arg Leu Thr Arg Phe Leu Ser Arg Val Ile Lys Cys Asp 
225                 230                 235                 240 


Pro Asp Cys Leu Arg Ala Cys Gln Glu Gln Ile Glu Ala Leu Leu Glu 
                245                 250                 255     


Ser Ser Leu Arg Gln Ala Gln Gln Asn Met Asp Pro Lys Ala Ala Glu 
            260                 265                 270         


Glu Glu Glu Glu Glu Glu Glu Glu Val Asp Leu Ala Cys Thr Pro Thr 
        275                 280                 285             


Asp Val Arg Asp Val Asp Ile 
    290                 295 


<210> 17
<211> 1365
<212> DNA
<213> Mus musculus

<400> 17
gtgggggtga gggggcctct ctagctcgcg gcctgtgtct atggtctggc ccgaagcgtc       60

cagctgcccg ggaccgatcc ccggtgtatg gcgccgcagg aaccggctcc cgggcccaga      120

taaagggcca cctccagagc tcttagccga gcgtaagatc ccctgcttcg agaatggctg      180

ccactcgata tgaacccgtg gctgaaattg gtgtcggtgc ctatgggacg gtgtacaaag      240

cccgagatcc ccacagtggc cactttgtgg ccctcaagag tgtgagagtt cctaatggag      300

gagcagctgg agggggcctt cccgtcagca cagttcgtga ggtggccttg ttaaggaggc      360

tggaggcctt tgaacatccc aatgttgtac ggctgatgga tgtctgtgct acttcccgaa      420

ctgatcggga catcaaggtc accctagtgt ttgagcatat agaccaggac ctgaggacat      480

acctggacaa agcacctcca ccgggcctgc cggttgagac cattaaggat ctaatgcgtc      540

agtttctaag cggcctggat tttcttcatg caaactgcat tgttcaccgg gacctgaagc      600

cagagaacat tctagtgaca agtaatggga ccgtcaagct ggctgacttt ggcctagcta      660

gaatctacag ctaccagatg gccctcacgc ctgtggtggt tacgctctgg taccgagctc      720

ctgaagttct tctgcagtct acatacgcaa cacccgtgga catgtggagc gttggctgta      780

tctttgcaga gatgttccgt cggaagcctc tcttctgtgg aaactctgaa gccgaccagt      840

tggggaaaat ctttgatctc attggattgc ctccagaaga cgactggcct cgagaggtat      900

ctctacctcg aggagccttt gcccccagag ggcctcggcc agtgcagtca gtggtgccag      960

agatggagga gtctggagcg cagctgctac tggaaatgct gacctttaac ccacataagc     1020

gaatctctgc cttccgagcc ctgcagcact cctacctgca caaggaggaa agcgacgcag     1080

agtgagaaga ggggctgcct ttcccagtct tggtggagaa accctcgctg aagcggcagc     1140

ctctgtttcc ccccaaggct gtggagaatc ctccagtttt ttacagagaa tattttaagc     1200

cttaaataac aagtccccac ctctccttac gaggttcacc cccattaccc tcccctagct     1260

ctacactaaa gggcaggtgt atctgtcttc ttccctccct gatttatact gggatctttt     1320

ttatacagga aaacaagaca agacaaaaaa aaaaaaaaaa aaaaa                     1365


<210> 18
<211> 303
<212> PRT
<213> Mus musculus

<400> 18
Met Ala Ala Thr Arg Tyr Glu Pro Val Ala Glu Ile Gly Val Gly Ala 
1               5                   10                  15      


Tyr Gly Thr Val Tyr Lys Ala Arg Asp Pro His Ser Gly His Phe Val 
            20                  25                  30          


Ala Leu Lys Ser Val Arg Val Pro Asn Gly Gly Ala Ala Gly Gly Gly 
        35                  40                  45              


Leu Pro Val Ser Thr Val Arg Glu Val Ala Leu Leu Arg Arg Leu Glu 
    50                  55                  60                  


Ala Phe Glu His Pro Asn Val Val Arg Leu Met Asp Val Cys Ala Thr 
65                  70                  75                  80  


Ser Arg Thr Asp Arg Asp Ile Lys Val Thr Leu Val Phe Glu His Ile 
                85                  90                  95      


Asp Gln Asp Leu Arg Thr Tyr Leu Asp Lys Ala Pro Pro Pro Gly Leu 
            100                 105                 110         


Pro Val Glu Thr Ile Lys Asp Leu Met Arg Gln Phe Leu Ser Gly Leu 
        115                 120                 125             


Asp Phe Leu His Ala Asn Cys Ile Val His Arg Asp Leu Lys Pro Glu 
    130                 135                 140                 


Asn Ile Leu Val Thr Ser Asn Gly Thr Val Lys Leu Ala Asp Phe Gly 
145                 150                 155                 160 


Leu Ala Arg Ile Tyr Ser Tyr Gln Met Ala Leu Thr Pro Val Val Val 
                165                 170                 175     


Thr Leu Trp Tyr Arg Ala Pro Glu Val Leu Leu Gln Ser Thr Tyr Ala 
            180                 185                 190         


Thr Pro Val Asp Met Trp Ser Val Gly Cys Ile Phe Ala Glu Met Phe 
        195                 200                 205             


Arg Arg Lys Pro Leu Phe Cys Gly Asn Ser Glu Ala Asp Gln Leu Gly 
    210                 215                 220                 


Lys Ile Phe Asp Leu Ile Gly Leu Pro Pro Glu Asp Asp Trp Pro Arg 
225                 230                 235                 240 


Glu Val Ser Leu Pro Arg Gly Ala Phe Ala Pro Arg Gly Pro Arg Pro 
                245                 250                 255     


Val Gln Ser Val Val Pro Glu Met Glu Glu Ser Gly Ala Gln Leu Leu 
            260                 265                 270         


Leu Glu Met Leu Thr Phe Asn Pro His Lys Arg Ile Ser Ala Phe Arg 
        275                 280                 285             


Ala Leu Gln His Ser Tyr Leu His Lys Glu Glu Ser Asp Ala Glu 
    290                 295                 300             


<210> 19
<211> 3796
<212> DNA
<213> Mus musculus

<400> 19
ttttctctgc ccggctttga tctctgctta acaacagtaa cgtcacacgg actacagggg       60

agttttgttg aagttgcaaa gtcctgcagc ctccagaggg ctgtcggcgc agtagcagag      120

agctacagac tccgcgcgct ccggagaccg gcagtacagc gcgaggcagc gcgcgtcagc      180

agccgccacc ggagcccaac cgagaccaca gccctcccca gacggccgcg ccatggaaca      240

ccagctcctg tgctgcgaag tggagaccat ccgccgcgcg taccctgaca ccaatctcct      300

caacgaccgg gtgctgcgag ccatgctcaa gacggaggag acctgtgcgc cctccgtatc      360

ttacttcaag tgcgtgcaga aggagattgt gccatccatg cggaaaatcg tggccacctg      420

gatgctggag gtctgtgagg agcagaagtg cgaagaggag gtcttcccgc tggccatgaa      480

ctacctggac cgcttcctgt ccctggagcc cttgaagaag agccgcctgc agctgctggg      540

ggccacctgc atgttcgtgg cctctaagat gaaggagacc attcccttga ctgccgagaa      600

gttgtgcatc tacactgaca actctatccg gcccgaggag ctgctgcaaa tggaactgct      660

tctggtgaac aagctcaagt ggaacctggc cgccatgact ccccacgatt tcatcgaaca      720

cttcctctcc aaaatgccag aggcggatga gaacaagcag accatccgca agcatgcaca      780

gacctttgtg gccctctgtg ccacagatgt gaagttcatt tccaacccac cctccatggt      840

agctgctggg agcgtggtgg ctgcgatgca aggcctgaac ctgggcagcc ccaacaactt      900

cctctcctgc taccgcacaa cgcactttct ttccagagtc atcaagtgtg acccggactg      960

cctccgtgcc tgccaggaac agattgaagc ccttctggag tcaagcctgc gccaggccca     1020

gcagaacgtc gaccccaagg ccactgagga ggagggggaa gtggaggaag aggctggtct     1080

ggcctgcacg cccaccgacg tgcgagatgt ggacatctga gggccaccgg gcaggcggga     1140

gccaccaagt agtggcaccc gcaaagagga aggagccagc ccgggtgctc ctgacgacgt     1200

cccccttggg gacatgttgt taccagaaga ggaagttttg ttctctttgt tggttgtttt     1260

tccttaatct ttctcctttc tatctgattt aagcaaaaga gaaaaaaata tctgaaagct     1320

gtcttaaaga gagagagaga gagatagaat ctgcatcacc ctgagagtag ggagccaggg     1380

ggtgctacaa aaatagaatt ctgtacccca gtaatcaact agttttctat taatgtgctt     1440

gtctgttcta agagtaggat taacacaggg gaagtcttga gaaggagttt tgattctttt     1500

atatgttttt aaaaaaaagc ttaagaaaca ttgctttaaa aaggaaggaa aaaaaataca     1560

gcaaaccatt gttaaagtag aagagttttt aggttgagaa atgtactctg ctttgctgaa     1620

aagccacagc ttaggccctc agcctcactc cctggcttgc tcagtgccta cagccctgtt     1680

acctgatacc tgtgctttat cccaggggtg ggcagacctc ttaaccttat agatggtcag     1740

tgcgacctct agtggtctca tggcgtgtgg cacaaccccc ctccccaggg ctcagcttaa     1800

tgtgccctct ccccccaaca acctgcaggt tcacagcacc agccacacag cggtagggat     1860

gaaatagtga cataatatat tctatttttg taaccttcct attttgtagc tctgtttaga     1920

gagatgctgg tttttgcctg aaggccctgc agcctgccca catcaggtta aacccacagc     1980

ttttgtgtgt ggtttgtttt gttgtgtttt ctttctctat gttccaaaac cattccattt     2040

caaagcactt ttggtcagct agctggaggc agtgttgctg gtgtgtgttg gggggagggg     2100

ttctaatgga atggatgggg atgtccacac acgcattcag atggctgtac aacaggttgt     2160

agggctggta gtatgaggtg cttgggaagt tttgttgggt caagaagaga gaactctgtt     2220

ctcgcaccac cgggatctgt cctgcaaagt tgaagggatc ctttggtgcc agctggtgtt     2280

tggaagtagg aaccatgatg gcattacctg gacaaggaga ttggggacaa ctcttaagtc     2340

tcacacagga ggcttttaaa cactaaaatg tctaatttat acttaaggct acagaagagt     2400

atttatggga aaggctgccc atgaccagtg tgactcaaag caatgtgatc tcccttgatt     2460

caaacgcaca cctctgccct gctggagaag gtttagggcc atgtctgaga gattggtctt     2520

tcattgggca acgggggggg ggggggggtc cttaaaaaaa aaaaaccaca aagacagaga     2580

tttggtctgc ttgactttcc caacccaatt ggccccattg gagagccatc caaactgagg     2640

aaaattaggg gactccaaaa gagtttgatt ctggcacatt cttgccgctg cccccaagtt     2700

aacaacagta ggtaatttgc acacctctgg ctctgtgcct ttctattagg actttttggc     2760

agaaggtgga gagcgggagg cttaagaggg gatgtgaggg aagaggtgaa ggtgggacca     2820

catgggacag gccacggctc ctctcatggc gctgctaccg atgactccca ggatcccaga     2880

cgttcagaac cagattctca ttgctttgta tctttcacgt tgttttcgct gctattggag     2940

ggtcagtttt gttttgtttt gttttacaat gtcagactgc catgttcaag ttttaatttc     3000

ctcatagagt gtatttacag atgccctttt ttgtactttt ttttttaatt gtgatctatt     3060

ttggcttaat gtgattaccg ctgtattcca aaaaaaaaaa aaaaacaggt tcctgttcac     3120

aatacctcat gtatcatcta gccatgcacg agcctggcag gcaggtgggc ggtctgcctc     3180

cagggatcct gggaccctga tggcgatcgt cctgtcatgc tgggcccttc atttgatctg     3240

ggacatagca tcacagcagt cagggcacct ggattgttct gttatcgata ttgtttcttg     3300

tagcggcctg ttgtgcatgc caccatgctg ctggcccggg gggatttgct ctgagtctcc     3360

ggtgcatcat ttaatctgtt aggttctagt gttccgtctt gttttgtgtt aattacagca     3420

ttgtgctaat gtaaagactc tgcctttgcg aagccagctg cagtgctgta ggcccccaag     3480

ttccctagca agctgccaaa ccaaaacggg caccaccagc tcagctgagg catcccagcc     3540

aggcaggacc cttgagggcc gctgtatcca tggtgatggg gtgaggtttt ggccaaaagg     3600

ccaaagactg gtggtgggtc cacggaatct gccctgtgac atgaaaggct ttgaggggct     3660

ctggctggtg gccaggttgg ctttttgtat ttctggttga cacaccatgg cgcttcccag     3720

cacagacatg tgaccagcat ggtccaggaa aaaaaaaaag acaaaaaatc tagaaaataa     3780

aattggtaaa atctca                                                     3796


<210> 20
<211> 295
<212> PRT
<213> Mus musculus

<400> 20
Met Glu His Gln Leu Leu Cys Cys Glu Val Glu Thr Ile Arg Arg Ala 
1               5                   10                  15      


Tyr Pro Asp Thr Asn Leu Leu Asn Asp Arg Val Leu Arg Ala Met Leu 
            20                  25                  30          


Lys Thr Glu Glu Thr Cys Ala Pro Ser Val Ser Tyr Phe Lys Cys Val 
        35                  40                  45              


Gln Lys Glu Ile Val Pro Ser Met Arg Lys Ile Val Ala Thr Trp Met 
    50                  55                  60                  


Leu Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu 
65                  70                  75                  80  


Ala Met Asn Tyr Leu Asp Arg Phe Leu Ser Leu Glu Pro Leu Lys Lys 
                85                  90                  95      


Ser Arg Leu Gln Leu Leu Gly Ala Thr Cys Met Phe Val Ala Ser Lys 
            100                 105                 110         


Met Lys Glu Thr Ile Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr 
        115                 120                 125             


Asp Asn Ser Ile Arg Pro Glu Glu Leu Leu Gln Met Glu Leu Leu Leu 
    130                 135                 140                 


Val Asn Lys Leu Lys Trp Asn Leu Ala Ala Met Thr Pro His Asp Phe 
145                 150                 155                 160 


Ile Glu His Phe Leu Ser Lys Met Pro Glu Ala Asp Glu Asn Lys Gln 
                165                 170                 175     


Thr Ile Arg Lys His Ala Gln Thr Phe Val Ala Leu Cys Ala Thr Asp 
            180                 185                 190         


Val Lys Phe Ile Ser Asn Pro Pro Ser Met Val Ala Ala Gly Ser Val 
        195                 200                 205             


Val Ala Ala Met Gln Gly Leu Asn Leu Gly Ser Pro Asn Asn Phe Leu 
    210                 215                 220                 


Ser Cys Tyr Arg Thr Thr His Phe Leu Ser Arg Val Ile Lys Cys Asp 
225                 230                 235                 240 


Pro Asp Cys Leu Arg Ala Cys Gln Glu Gln Ile Glu Ala Leu Leu Glu 
                245                 250                 255     


Ser Ser Leu Arg Gln Ala Gln Gln Asn Val Asp Pro Lys Ala Thr Glu 
            260                 265                 270         


Glu Glu Gly Glu Val Glu Glu Glu Ala Gly Leu Ala Cys Thr Pro Thr 
        275                 280                 285             


Asp Val Arg Asp Val Asp Ile 
    290                 295 


