                         SEQUENCE LISTING

<110>  NATHAN, ILANA
       KHALFIN, BORIS
 
<120>  CATHEPSIN C, CELA3A, CELA1 INHIBITION IN PREVENTING OR TREATING 
       CELLULAR NECROSIS

<130>  NATHAN7408PC2

<150>  US 62/143,821
<151>  2015-04-07

<150>  US 62/170,717
<151>  2015-06-04

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  1
atgatctgca tcagttgtaa a                                                 21


<210>  2
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  2
cggcaacatg ctggtccttt a                                                 21


<210>  3
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  3
ctgcctttgg ctgcaacttc a                                                 21


<210>  4
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  4
aattctccga acgtgtcacg t                                                 21


<210>  5
<211>  6099
<212>  DNA
<213>  Homo sapiens

<400>  5
cgtagctatt tcaaggcgcg cgcctcgtgg tggactcacc gctagcccgc agcgctcggc       60

ttcctggtaa ttcttcacct cttttctcag ctccctgcag catgggtgct gggccctcct      120

tgctgctcgc cgccctcctg ctgcttctct ccggcgacgg cgccgtgcgc tgcgacacac      180

ctgccaactg cacctatctt gacctgctgg gcacctgggt cttccaggtg ggctccagcg      240

gttcccagcg cgatgtcaac tgctcggtta tgggaccaca agaaaaaaaa gtagtggtgt      300

accttcagaa gctggataca gcatatgatg accttggcaa ttctggccat ttcaccatca      360

tttacaacca aggctttgag attgtgttga atgactacaa gtggtttgcc ttttttaagg      420

atgtcactga ttttatcagt catttgttca tgcagctggg aactgtgggg atatatgatt      480

tgccacatct gaggaacaaa ctggccatga acagacgttg gggctaagag acagagcagc      540

ctgcgacagt gtggacctac ctgtagcagc tagcaaaggc ctctagcagc tacagtccct      600

tctggagtct ttatttgcat gcaaaatgca aaggagtcct ggtgacctac ctccaaggca      660

gctgccctcc tgaacactcc cttggaaaac agtaaacatc attttggaat gtgaacaacc      720

agagactaca caggagaaag gaaaaaaaaa ttctgaagat gcaaaatctt gggtggcttc      780

accgttcagt tttttaataa aaggaacaat atacaacacg ttgttctttt tctcttttga      840

aatcccttct attacagtga tttttttcta agattgtcag gatttgaagt gtatgttttg      900

ttttattcac agcgtaaatt ttattcacag tttaactgtc tgcctgagtg tctttccttt      960

ctctaattac cttgaggaac ccaagagcct gttgtaagga gaaaataagg cccttggatc     1020

tcttgagatt cacagatata agttattgaa gggaagatgg tcctatggag gacatattta     1080

aagaagggaa aaaagaggct ttctcagata tgtcagactg ctatagtata cttctacaga     1140

ttatagacct ccagtacctc tggccagaaa gatggtatcg taaacaccct attttttttc     1200

ttttcttttt tcattaggta caagctttgt gctaagaagt tgacatacta taagctacaa     1260

aagttctgta aagtagatat aactagtttc attttataga tagagaaaat taatctctta     1320

cagtgctaag ctcacagagt ttctaactgt aaaatgctag aacttgtctt tcaagcctaa     1380

agacttcctt ggggctaaat agtgaaaaaa gccatttcac aaataagtaa atggtattta     1440

gaggcatatt tggatttcct ggtaaattcc agtctgtgag catcatgaat attagtttaa     1500

tgttgcatgg gctcatgttg aagttttaag agaagaactg ccttgaagct taggtttcct     1560

tagctattag gctactgact ttcttgccta aaccagggtt ttttcattga agaccaaaac     1620

ttaccttctc cttcagtttg tagtttggaa attggtagaa gagctttgta aacttcaaat     1680

taagtacaaa ctaagtgtca tagtcaaatt tactaatctt aattacagta ttgttcaact     1740

gattgctatc ttctagctct ttcctgccga ataatggtct tgtttcctgc tctgttggtt     1800

tagagctgac ttctttcagc tttggtaagc ctgaaattat ggggttatgt ttaattcata     1860

ttgtctgggt ggactttcct ctcttgcatt tctgcttgaa tagaagaatt tttctctaga     1920

gagtagtttg tcatccttac tctgttgatt cagatgactc tttgtatgat ctgagaggta     1980

tactgttctg ctattctgag aagaagtatt tcagaaagat gaattaagag tacagtggac     2040

tgctcccacc tggaaacttt tatctatctc acctctggac ctgataaatt ctttatcact     2100

caggaccttg atgacgctgc tctctgaaac cctccccagc tctctctatt accgtgagaa     2160

acatcagaac tttggttccc attgcatatc gcaggtacct ctgctttcat gccatgctgt     2220

aatggagtga ttgggtagca tgttttcatc tctttccaga ttgaaaatct gtatttctcc     2280

ctgtatatct tcaacaccta atgcacatag aactttgtag gtacctggaa aatgcaccac     2340

agttttcttt tctttttgca gacttttcac aagtattacc aacttacaaa gaattaattt     2400

tgtaggattc tagaaagaca aatcaggaat ggtgccatat acatcttttt tgattccctg     2460

ctctaaagaa tattatcagg ttaccttcct gcagagtttt aaaagaattg catatttcaa     2520

gctgactttc aggatgtaaa tataaccaaa gcaactgata tgtaaaaaat atattcaatg     2580

gcattcctag attttcttct agggtgtttt attgttttgg gttttacatt taagtcttta     2640

atccatcttg agttaatttt tgtataggta taagaaaggg gtccagtttt aattttctgc     2700

gtatggctag ccagttctcc cagcaccatt tattaaatag ggaatccttt ccctattgtt     2760

tgtttttgta cggtttgtca aagattagat ggttgtagat gtgtggtctt atttctgaga     2820

tcttcattct cttccactgg tctatgtgtc tgtttttgta ccatgctttt ttggttactg     2880

tagccttgta gtatagtatg aaagatagca tgatgcctcc aggtttgttc tttttgctta     2940

ggattgtctt ggctatacga gctttttttt ggttctatat gaattttaaa atagtttctt     3000

ctaattgtgt gaagaatgtt aatggtagtt taatgggaat agcattgaat ctgtgaattg     3060

ctttgggcag tatggccatt ttcatgatat tgattcttcc tatccatgag catgtaacgt     3120

ttttcccttc gtttgtgtcc tctctcattt ccttgagtag tggtttgtag ttctccttga     3180

agagatcctt cacttcttct gtattcctag atattttatt ctctctgtag ctattgggaa     3240

tgggagttca ttcatgattt tgctctctgc ttgccttttg ttggtgtata gggatcctgg     3300

tgacttctgc acattgattt tgtatcctga gactttaccg aagttgctta tcagcttaag     3360

aagcttttgg gctgagatga tggggttttc tagatatagg atcatgttat cttcaaacaa     3420

agacaatttg acttcctctc ttcctatttg agtacgcttt atttctttct cttgcctgat     3480

tgccctggcc agaactccca atactatatt gaataagaat ggtgagagag ggcatccttg     3540

tcttgtgcca gttttcacgg ggaatgcttc cagcttttgc ccattcagta tgatattatc     3600

tgtgggtttc tcataaaaag ctcttattat ttgagatacg ttccttcaat acctagttta     3660

ttgagagttt ttaacatgaa gcgatgttga attgtatcga aggccttttc tgtgtctatt     3720

gagataatca tgtggttttt gtctttagtt ctgtttatgt gatgaatgac gtttattgat     3780

ttgcatatgt tgaaccggcc ttgcatcctg gggatgaagc caacttgact gtggtagata     3840

agcttttgga tgtgctgctg gatttggttt atcagtattt cattgagatt ttttgcgtcg     3900

aagttcatca gggatattgg actgaagttt tctttttgtt gtcgtatctc tgccaggttt     3960

tggtatcagg atgatgctgg cctcataaaa tgagttaggg aggagtccct ccttttcaat     4020

tgtttggaat agtttcagaa gaaagggtat cagctcctct ttgtacctct ggtagaattc     4080

aactgtaaat ccatctggtc ctggactttt tttcattagt aggctattta ttactgcctc     4140

actttcataa cttgttattg atctattcag ggatccaact tcttcctgat tcagtcttgg     4200

gagtgtgtat gcatccagga atttatccat ttcttctaga ttttctagtt tctttgcata     4260

gaggtgtttg tagtatttgc tgttggttgt ttgtacttct gtgagatcag tggtggtatc     4320

ctgtttatca ttttttattg tgtctgtttg attcttctct tatttttgac aaagctgaca     4380

aaaagaagca atagggaaag gactctctat tcaattaatc ctactgtata tctggctagc     4440

catatgcaga aaattgaaac tgttcctgtt tcttaatcca tatacgaaaa tcaacttacg     4500

atggattaaa gacttaaatg taaaacccaa aattataaaa ccctggaata gaatataggc     4560

aatatcattc tggacatagg aatgggcaaa gattttatga gaaagacacc aaaagcaatt     4620

acaacaaaag caaaaattgg caaatgagat ctaattaaac taaagagctc tgcacagcaa     4680

aagaaactac tgtcagagtg aacaggcaac caacagaatg ggagaaaatt ttttcaatct     4740

atccatatga caaaggtcta acatccagaa tctacaagga acttaacaaa tttacaagaa     4800

aaaaggagcc ccattaaaaa gttggcaaag aacatgaaca gacacttccc agaagatatt     4860

catgtggcca ataaacatga agaaaagctc aacatcactg accattagag acgtgcatat     4920

caaaatcaca atgagatacc atctcatgtc acaatggtga ttattaaaaa gtcaaacaac     4980

atgctagtga ggttgtagag aaataagaac gcttttacac tgttggtggg aatgtcaact     5040

aattcaacca ctgtggaaga cagtgtggtg attcctcaag gatttagaac cagaaatatc     5100

attactgcat atagacccaa aggaatagaa atcattctat tacaaagata catgcacatg     5160

tatgtttatt acagcactat tcacaatagc aaagacatgg aatcaaccca aatgctcatc     5220

agtgatagac tggaaaaaga gaatgtggaa cataaacacc atggaatact atgcagcaat     5280

aaaaaggaat gagatcctgt ccttttcagg gacatggatg gagttggaag ctgttatcct     5340

cagcaaacta atgcaggaac agaaaaccaa ccaccacatg ttctcactta taagtgggag     5400

ctgaacaata gaacacatgg gcacagggag gggaataaca cacactgggg ccagtcaggg     5460

ggtggggggt caagctgagg gagagcatta gaaaaaatag ctaatgcatt ctgggcttaa     5520

cccatttatg cctagtgttc catttctgga atgctaagca tgtggaagtt ctttatatcc     5580

tgctcaaggt cattgccaag gtctgatttt tcacattcaa caaattgcaa cctctggcat     5640

aaatgggtta atacctaggt gatgagttga taggtgcagg aaaccaccat ggcacatgtt     5700

tatctatgta agaaacctgc acatcctaca catgtaccct ggaacttaaa aaatttaaaa     5760

tatatatgta tatatattta atatggaatt ttaaaaatta ctaatgagtt cttttatctg     5820

agtaattttg catcaacatg cttttattat ggaagagaag attcagtgag tacaaaattg     5880

cagatacatg tgtcagaaga tccctgaata taataaggct tagtattctg tgtcataatt     5940

gcctgtttgt attcctctct ggtctttaaa cttcattagg gcaaggatca actccatctt     6000

actaaccatt tgattcccta tgtattacac gatatatgac caataataag ccttcaataa     6060

atacttgtaa aataaagaat gttatgtaat aaaaaaaaa                            6099


<210>  6
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gly Ala Gly Pro Ser Leu Leu Leu Ala Ala Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ser Gly Asp Gly Ala Val Arg Cys Asp Thr Pro Ala Asn Cys Thr Tyr 
            20                  25                  30          


Leu Asp Leu Leu Gly Thr Trp Val Phe Gln Val Gly Ser Ser Gly Ser 
        35                  40                  45              


Gln Arg Asp Val Asn Cys Ser Val Met Gly Pro Gln Glu Lys Lys Val 
    50                  55                  60                  


Val Val Tyr Leu Gln Lys Leu Asp Thr Ala Tyr Asp Asp Leu Gly Asn 
65                  70                  75                  80  


Ser Gly His Phe Thr Ile Ile Tyr Asn Gln Gly Phe Glu Ile Val Leu 
                85                  90                  95      


Asn Asp Tyr Lys Trp Phe Ala Phe Phe Lys Asp Val Thr Asp Phe Ile 
            100                 105                 110         


Ser His Leu Phe Met Gln Leu Gly Thr Val Gly Ile Tyr Asp Leu Pro 
        115                 120                 125             


His Leu Arg Asn Lys Leu Ala Met Asn Arg Arg Trp Gly 
    130                 135                 140     


<210>  7
<211>  777
<212>  DNA
<213>  Homo sapiens

<400>  7
atgctggtcc tttatggaca cagcacccag gaccttccgg aaaccaatgc ccgcgtagtc       60

ggagggactg aggccgggag gaattcctgg ccctctcaga tttccctcca gtaccggtct      120

ggaggttccc ggtatcacac ctgtggaggg acccttatca gacagaactg ggtgatgaca      180

gctgctcact gcgtggatta ccagaagact ttccgcgtgg tggctggaga ccataacctg      240

agccagaatg atggcactga gcagtacgtg agtgtgcaga agatcgtggt gcatccatac      300

tggaacagcg ataacgtggc tgccggctat gacatcgccc tgctgcgcct ggcccagagc      360

gttaccctca atagctatgt ccagctgggt gttctgcccc aggagggagc catcctggct      420

aacaacagtc cctgctacat cacaggctgg ggcaagacca agaccaatgg gcagctggcc      480

cagaccctgc agcaggctta cctgccctct gtggactacg ccatctgctc cagctcctcc      540

tactggggct ccactgtgaa gaacaccatg gtgtgtgctg gtggagatgg agttcgctct      600

ggatgccagg gtgactctgg gggccccctc cattgcttgg tgaatggcaa gtattctgtc      660

catggagtga ccagctttgt gtccagccgg ggctgtaatg tctccaggaa gcctacagtc      720

ttcacccagg tctctgctta catctcctgg ataaataatg tcatcgcctc caactga         777


<210>  8
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Leu Val Leu Tyr Gly His Ser Thr Gln Asp Leu Pro Glu Thr Asn 
1               5                   10                  15      


Ala Arg Val Val Gly Gly Thr Glu Ala Gly Arg Asn Ser Trp Pro Ser 
            20                  25                  30          


Gln Ile Ser Leu Gln Tyr Arg Ser Gly Gly Ser Arg Tyr His Thr Cys 
        35                  40                  45              


Gly Gly Thr Leu Ile Arg Gln Asn Trp Val Met Thr Ala Ala His Cys 
    50                  55                  60                  


Val Asp Tyr Gln Lys Thr Phe Arg Val Val Ala Gly Asp His Asn Leu 
65                  70                  75                  80  


Ser Gln Asn Asp Gly Thr Glu Gln Tyr Val Ser Val Gln Lys Ile Val 
                85                  90                  95      


Val His Pro Tyr Trp Asn Ser Asp Asn Val Ala Ala Gly Tyr Asp Ile 
            100                 105                 110         


Ala Leu Leu Arg Leu Ala Gln Ser Val Thr Leu Asn Ser Tyr Val Gln 
        115                 120                 125             


Leu Gly Val Leu Pro Gln Glu Gly Ala Ile Leu Ala Asn Asn Ser Pro 
    130                 135                 140                 


Cys Tyr Ile Thr Gly Trp Gly Lys Thr Lys Thr Asn Gly Gln Leu Ala 
145                 150                 155                 160 


Gln Thr Leu Gln Gln Ala Tyr Leu Pro Ser Val Asp Tyr Ala Ile Cys 
                165                 170                 175     


Ser Ser Ser Ser Tyr Trp Gly Ser Thr Val Lys Asn Thr Met Val Cys 
            180                 185                 190         


Ala Gly Gly Asp Gly Val Arg Ser Gly Cys Gln Gly Asp Ser Gly Gly 
        195                 200                 205             


Pro Leu His Cys Leu Val Asn Gly Lys Tyr Ser Val His Gly Val Thr 
    210                 215                 220                 


Ser Phe Val Ser Ser Arg Gly Cys Asn Val Ser Arg Lys Pro Thr Val 
225                 230                 235                 240 


Phe Thr Gln Val Ser Ala Tyr Ile Ser Trp Ile Asn Asn Val Ile Ala 
                245                 250                 255     


Ser Asn 
        


<210>  9
<211>  813
<212>  DNA
<213>  Homo sapiens

<400>  9
atgatgctcc ggctgctcag ttccctcctc cttgtggccg ttgcctcagg ctatggccca       60

ccttcctctc actcttccag ccgcgttgtc catggtgagg atgcggtccc ctacagctgg      120

ccctggcagg tttccctgca gtatgagaaa agtggaagct tctaccacac gtgtggcggt      180

agcctcatcg cccccgattg ggttgtgact gccggccact gcatctcgag ggatctgacc      240

taccaggtgg tgttgggtga gtacaacctt gctgtgaagg agggccccga gcaggtgatc      300

cccatcaact ctgaggagct gtttgtgcat ccactctgga accgctcgtg tgtggcctgt      360

ggcaatgaca tcgccctcat caagctctca cgcagcgccc agctgggaga tgccgtccag      420

ctcgcctcac tccctcccgc tggtgacatc cttcccaaca agacaccctg ctacatcacc      480

ggctggggcc gtctctatac caatgggcca ctcccagaca agctgcagca ggcccggctg      540

cccgtggtgg actataagca ctgctccagg tggaactggt ggggttccac cgtgaagaaa      600

accatggtgt gtgctggagg gtacatccgc tccggctgca acggtgactc tggaggaccc      660

ctcaactgcc ccacagagga tggtggctgg caggtccacg gtgtgaccag ctttgtttct      720

gcctttggct gcaacttcat ctggaagccc acggtgttca ctcgagtctc cgccttcatc      780

gactggattg aggagaccat agcaagccac tag                                   813


<210>  10
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Met Leu Arg Leu Leu Ser Ser Leu Leu Leu Val Ala Val Ala Ser 
1               5                   10                  15      


Gly Tyr Gly Pro Pro Ser Ser His Ser Ser Ser Arg Val Val His Gly 
            20                  25                  30          


Glu Asp Ala Val Pro Tyr Ser Trp Pro Trp Gln Val Ser Leu Gln Tyr 
        35                  40                  45              


Glu Lys Ser Gly Ser Phe Tyr His Thr Cys Gly Gly Ser Leu Ile Ala 
    50                  55                  60                  


Pro Asp Trp Val Val Thr Ala Gly His Cys Ile Ser Arg Asp Leu Thr 
65                  70                  75                  80  


Tyr Gln Val Val Leu Gly Glu Tyr Asn Leu Ala Val Lys Glu Gly Pro 
                85                  90                  95      


Glu Gln Val Ile Pro Ile Asn Ser Glu Glu Leu Phe Val His Pro Leu 
            100                 105                 110         


Trp Asn Arg Ser Cys Val Ala Cys Gly Asn Asp Ile Ala Leu Ile Lys 
        115                 120                 125             


Leu Ser Arg Ser Ala Gln Leu Gly Asp Ala Val Gln Leu Ala Ser Leu 
    130                 135                 140                 


Pro Pro Ala Gly Asp Ile Leu Pro Asn Lys Thr Pro Cys Tyr Ile Thr 
145                 150                 155                 160 


Gly Trp Gly Arg Leu Tyr Thr Asn Gly Pro Leu Pro Asp Lys Leu Gln 
                165                 170                 175     


Gln Ala Arg Leu Pro Val Val Asp Tyr Lys His Cys Ser Arg Trp Asn 
            180                 185                 190         


Trp Trp Gly Ser Thr Val Lys Lys Thr Met Val Cys Ala Gly Gly Tyr 
        195                 200                 205             


Ile Arg Ser Gly Cys Asn Gly Asp Ser Gly Gly Pro Leu Asn Cys Pro 
    210                 215                 220                 


Thr Glu Asp Gly Gly Trp Gln Val His Gly Val Thr Ser Phe Val Ser 
225                 230                 235                 240 


Ala Phe Gly Cys Asn Phe Ile Trp Lys Pro Thr Val Phe Thr Arg Val 
                245                 250                 255     


Ser Ala Phe Ile Asp Trp Ile Glu Glu Thr Ile Ala Ser His 
            260                 265                 270 


<210>  11
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  11

Cys Ile Ser Arg Asp Leu Thr Tyr 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  12

Gly Glu Tyr Asn Leu Ala Val Lys 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  13

Pro Ile Asn Ser Glu Glu Leu Phe 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  14

Gln Gln Ala Arg Leu Pro Val Val 
1               5               


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  15

Thr Met Val Cys Ala Gly Gly Tyr 
1               5               


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  16

Ala Phe Gly Cys Asn Phe Ile Trp Lys 
1               5                   


<210>  17
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  17

Met Leu Val Leu Tyr Gly His Ser Thr Gln Asp Leu Pro Glu Thr Asn 
1               5                   10                  15      


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  18

Ala Gly Arg Asn Ser Trp Pro Ser 
1               5               


<210>  19
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  19

Leu Ser Gln Asn Asp Gly Thr Glu Gln Tyr 
1               5                   10  


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  20

Ser Asp Asn Val Ala Ala Gly Tyr 
1               5               


<210>  21
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial seqeunce

<400>  21

Ala Tyr Leu Pro Ser Val 
1               5       


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  22

Ala Ile Cys Ser Ser Ser Ser Tyr 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  23

Ser Arg Gly Cys Asn Val Ser Arg 
1               5               


<210>  24
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  24
tgcatctcga gggatctgac ctac                                              24


<210>  25
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  25
ggtgagtaca accttgctgt gaag                                              24


<210>  26
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  26
cccatcaact ctgaggagct gttt                                              24


<210>  27
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  27
cagcaggccc ggctgcccgt ggtg                                              24


<210>  28
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  28
accatggtgt gtgctggagg gtac                                              24


<210>  29
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  29
gcctttggct gcaacttcat ctggaag                                           27


<210>  30
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  30
atgctggtcc tttatggaca cagcacccag gaccttccgg aaaccaatg                   49


<210>  31
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  31
gccgggagga attcctggcc ctct                                              24


<210>  32
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  32
ctgagccaga atgatggcac tgagcagtac                                        30


<210>  33
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  33
agcgataacg tggctgccgg ctat                                              24


<210>  34
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  34
gcttacctgc cctctgtg                                                     18


<210>  35
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  35
gccatctgct ccagctcctc ctac                                              24


<210>  36
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  36
agccggggct gtaatgtctc cagg                                              24


<210>  37
<211>  813
<212>  DNA
<213>  Homo sapiens

<400>  37
atgatgctcc ggctgctcag ttccctcctc cttgtggccg ttgcctcagg ctatggccca       60

ccttcctctc gcccttccag ccgcgttgtc aatggtgagg atgcggtccc ctacagctgg      120

ccctggcagg tttccctgca gtatgagaaa agcggaagct tctaccacac ctgtggcggt      180

agcctcatcg cccccgactg ggttgtgact gccggccact gcatctcgag ctcccggacc      240

taccaggtgg tgttgggcga gtacgaccgt gctgtgaagg agggccccga gcaggtgatc      300

cccatcaact ctggggacct ctttgtgcat ccactctgga accgctcgtg tgtggcctgt      360

ggcaatgaca tcgccctcat caagctctca cgcagcgccc agctgggaga cgccgtccag      420

ctcgcctcac tccctccggc tggtgacatc cttcccaacg agacaccctg ctacatcacc      480

ggctggggcc gtctctatac caacgggcca ctcccagaca agctgcagga ggccctgctg      540

ccggtggtgg actatgaaca ctgctccagg tggaactggt ggggttcctc cgtgaagaag      600

accatggtgt gtgctggagg ggacatccgc tccggctgca atggtgactc tggaggaccc      660

ctcaactgcc ccacagagga tggtggctgg caggtccatg gcgtgaccag ctttgtttct      720

gcctttggct gcaacacccg caggaagccc acggtgttca ctcgagtctc cgccttcatt      780

gactggattg aggagaccat agcaagccac tag                                   813


<210>  38
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Met Leu Arg Leu Leu Ser Ser Leu Leu Leu Val Ala Val Ala Ser 
1               5                   10                  15      


Gly Tyr Gly Pro Pro Ser Ser Arg Pro Ser Ser Arg Val Val Asn Gly 
            20                  25                  30          


Glu Asp Ala Val Pro Tyr Ser Trp Pro Trp Gln Val Ser Leu Gln Tyr 
        35                  40                  45              


Glu Lys Ser Gly Ser Phe Tyr His Thr Cys Gly Gly Ser Leu Ile Ala 
    50                  55                  60                  


Pro Asp Trp Val Val Thr Ala Gly His Cys Ile Ser Ser Ser Arg Thr 
65                  70                  75                  80  


Tyr Gln Val Val Leu Gly Glu Tyr Asp Arg Ala Val Lys Glu Gly Pro 
                85                  90                  95      


Glu Gln Val Ile Pro Ile Asn Ser Gly Asp Leu Phe Val His Pro Leu 
            100                 105                 110         


Trp Asn Arg Ser Cys Val Ala Cys Gly Asn Asp Ile Ala Leu Ile Lys 
        115                 120                 125             


Leu Ser Arg Ser Ala Gln Leu Gly Asp Ala Val Gln Leu Ala Ser Leu 
    130                 135                 140                 


Pro Pro Ala Gly Asp Ile Leu Pro Asn Glu Thr Pro Cys Tyr Ile Thr 
145                 150                 155                 160 


Gly Trp Gly Arg Leu Tyr Thr Asn Gly Pro Leu Pro Asp Lys Leu Gln 
                165                 170                 175     


Glu Ala Leu Leu Pro Val Val Asp Tyr Glu His Cys Ser Arg Trp Asn 
            180                 185                 190         


Trp Trp Gly Ser Ser Val Lys Lys Thr Met Val Cys Ala Gly Gly Asp 
        195                 200                 205             


Ile Arg Ser Gly Cys Asn Gly Asp Ser Gly Gly Pro Leu Asn Cys Pro 
    210                 215                 220                 


Thr Glu Asp Gly Gly Trp Gln Val His Gly Val Thr Ser Phe Val Ser 
225                 230                 235                 240 


Ala Phe Gly Cys Asn Thr Arg Arg Lys Pro Thr Val Phe Thr Arg Val 
                245                 250                 255     


Ser Ala Phe Ile Asp Trp Ile Glu Glu Thr Ile Ala Ser His 
            260                 265                 270 


<210>  39
<211>  810
<212>  DNA
<213>  Homo sapiens

<400>  39
atgataagga cgctgctgct gtccactttg gtggctggag ccctcagttg tggggacccc       60

acttacccac cttatgtgac tagggtggtt ggcggtgaag aagcgaggcc caacagctgg      120

ccctggcagg tctccctgca gtacagctcc aatggcaagt ggtaccacac ctgcggaggg      180

tccctgatag ccaacagctg ggtcctgacg gctgcccact gcatcagctc ctccaggacc      240

taccgcgtgg ggctgggccg gcacaacctc tacgttgcgg agtccggctc gctggcagtc      300

agtgtctcta agattgtggt gcacaaggac tggaactcca accaaatctc caaagggaac      360

gacattgccc tgctcaaact ggctaacccc gtctccctca ccgacaagat ccagctggcc      420

tgcctccctc ctgccggcac cattctaccc aacaactacc cctgctacgt cacgggctgg      480

ggaaggctgc agaccaacgg ggctgttcct gatgtcctgc agcagggccg gttgctggtt      540

gtggactatg ccacctgctc cagctctgcc tggtggggca gcagcgtgaa aaccagtatg      600

atctgtgctg ggggtgatgg cgtgatctcc agctgcaacg gagactctgg cgggccactg      660

aactgtcagg cgtctgacgg ccggtggcag gtgcacggca tcgtcagctt cgggtctcgc      720

ctcggctgca actactacca caagccctcc gtcttcacgc gggtctccaa ttacatcgac      780

tggatcaatt cggtgattgc aaataactaa                                       810


<210>  40
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ile Arg Thr Leu Leu Leu Ser Thr Leu Val Ala Gly Ala Leu Ser 
1               5                   10                  15      


Cys Gly Asp Pro Thr Tyr Pro Pro Tyr Val Thr Arg Val Val Gly Gly 
            20                  25                  30          


Glu Glu Ala Arg Pro Asn Ser Trp Pro Trp Gln Val Ser Leu Gln Tyr 
        35                  40                  45              


Ser Ser Asn Gly Lys Trp Tyr His Thr Cys Gly Gly Ser Leu Ile Ala 
    50                  55                  60                  


Asn Ser Trp Val Leu Thr Ala Ala His Cys Ile Ser Ser Ser Arg Thr 
65                  70                  75                  80  


Tyr Arg Val Gly Leu Gly Arg His Asn Leu Tyr Val Ala Glu Ser Gly 
                85                  90                  95      


Ser Leu Ala Val Ser Val Ser Lys Ile Val Val His Lys Asp Trp Asn 
            100                 105                 110         


Ser Asn Gln Ile Ser Lys Gly Asn Asp Ile Ala Leu Leu Lys Leu Ala 
        115                 120                 125             


Asn Pro Val Ser Leu Thr Asp Lys Ile Gln Leu Ala Cys Leu Pro Pro 
    130                 135                 140                 


Ala Gly Thr Ile Leu Pro Asn Asn Tyr Pro Cys Tyr Val Thr Gly Trp 
145                 150                 155                 160 


Gly Arg Leu Gln Thr Asn Gly Ala Val Pro Asp Val Leu Gln Gln Gly 
                165                 170                 175     


Arg Leu Leu Val Val Asp Tyr Ala Thr Cys Ser Ser Ser Ala Trp Trp 
            180                 185                 190         


Gly Ser Ser Val Lys Thr Ser Met Ile Cys Ala Gly Gly Asp Gly Val 
        195                 200                 205             


Ile Ser Ser Cys Asn Gly Asp Ser Gly Gly Pro Leu Asn Cys Gln Ala 
    210                 215                 220                 


Ser Asp Gly Arg Trp Gln Val His Gly Ile Val Ser Phe Gly Ser Arg 
225                 230                 235                 240 


Leu Gly Cys Asn Tyr Tyr His Lys Pro Ser Val Phe Thr Arg Val Ser 
                245                 250                 255     


Asn Tyr Ile Asp Trp Ile Asn Ser Val Ile Ala Asn Asn 
            260                 265                 


