                         SEQUENCE LISTING

<110>  Schiller, Martin R.
       Strong, Christy L.
 
<120>  Compositions Comprising TALENs and Methods of Treating HIV

<130>  37474.0040P1

<150>  62/140,048
<151>  2015-03-30

<150>  62/262,232
<151>  2015-12-09

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Human immunodeficiency virus

<400>  1
tctctggtta gaccagatct                                                   20


<210>  2
<211>  17
<212>  DNA
<213>  Human immunodeficiency virus

<400>  2
taactaggga acccact                                                      17


<210>  3
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' TALE binding target

<400>  3
taagcactgg gttccctagt ta                                                22


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' TALE binding mutant

<400>  4
tctctagtca gaccagatca                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' TALE binding mutant

<400>  5
tctctagtca gaccagatcc                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' TALE binding mutant

<400>  6
tctcttgtca gaccagatca                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5'TALE binding mutant

<400>  7
tctcttgtca gaccagatcc                                                   20


<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear localization signal (NLS)

<400>  8

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  9
gagcctggga gctctctggc                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  10
ctcggaccct cgagagaccg                                                   20


<210>  11
<211>  672
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T256/T258 5'TALEN FokI Gblock ELD.Sharkey

<400>  11
gtcgcgggat cccaactagt caaaagtgaa ctggaggaga agaaatctga acttcgtcat       60

aaattgaaat atgtgcctca tgaatatatt gaattaattg aaattgccag aaatcccact      120

caggatagaa ttcttgaaat gaaggtaatg gaatttttta tgaaagttta tggatataga      180

ggtgagcatt tgggtggatc aaggaaaccg gacggagcaa tttatactgt cggatctcct      240

attgattacg gtgtgatcgt ggatactaaa gcttatagcg gaggttataa tctgccaatt      300

ggccaagcag atgaaatgga gcgatatgtc gaagaaaatc aaacacgaga caaacatctg      360

aaccctaatg aatggtggaa agtctatcca tcttctgtaa cggaatttaa gtttttattt      420

gtgagtggtc actttaaagg aaactacaaa gctcagctta cacgattaaa tcatatcact      480

aattgtaatg gagctgttct tagtgtagaa gagcttttaa ttggtggaga aatgattaaa      540

gccggcacat taaccttaga ggaagtcaga cggaaattta ataacggcga gataaacttt      600

taagggccct tcgaaggtaa gcctatccct aaccctctcc tcggtctcga ttctacgcgt      660

accggtcatc at                                                          672


<210>  12
<211>  672
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T278 3'TALEN FokI Gblock (672bps) KKR.Sharkey

<400>  12
gtcgcgggat cccaactagt caaaagtgaa ctggaggaga agaaatctga acttcgtcat       60

aaattgaaat atgtgcctca tgaatatatt gaattaattg aaattgccag aaatcccact      120

caggatagaa ttcttgaaat gaaggtaatg gaatttttta tgaaagttta tggatataga      180

ggtgagcatt tgggtggatc aaggaaaccg gacggagcaa tttatactgt cggatctcct      240

attgattacg gtgtgatcgt ggatactaaa gcttatagcg gaggttataa tctgccaatt      300

ggccaagcag atgaaatgca acgatatgtc aaggaaaatc aaacacgaaa caaacatatc      360

aaccctaatg aatggtggaa agtctatcca tcttctgtaa cggaatttaa gtttttattt      420

gtgagtggtc actttaaagg aaactacaaa gctcagctta cacgattaaa tcggaagact      480

aattgtaatg gagctgttct tagtgtagaa gagcttttaa ttggtggaga aatgattaaa      540

gccggcacat taaccttaga ggaagtcaga cggaaattta ataacggcga gataaacttt      600

taagggccct tcgaaggtaa gcctatccct aaccctctcc tcggtctcga ttctacgcgt      660

accggtcatc at                                                          672


<210>  13
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T256/T258 5' TALEN FokI ELD Sharkey Amino Acid Sequence; shaded 
       portion refers to the protein coding region open reading frame

<400>  13

Val Ala Gly Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser 
1               5                   10                  15      


Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu 
            20                  25                  30          


Ile Glu Ile Ala Arg Asn Pro Thr Gln Asp Arg Ile Leu Glu Met Glu 
        35                  40                  45              


Thr Lys Val Met Glu Thr Glu Phe Phe Met Glu Thr Lys Val Tyr Gly 
    50                  55                  60                  


Tyr Arg Gly Glu His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile 
65                  70                  75                  80  


Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys 
                85                  90                  95      


Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met 
            100                 105                 110         


Glu Thr Glu Arg Tyr Val Glu Glu Asn Gln Thr Arg Asp Lys His Leu 
        115                 120                 125             


Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe 
    130                 135                 140                 


Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln 
145                 150                 155                 160 


Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser 
                165                 170                 175     


Val Glu Glu Leu Leu Ile Gly Gly Glu Met Glu Thr Ile Lys Ala Gly 
            180                 185                 190         


Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile 
        195                 200                 205             


Asn Phe Leu Gly Pro Phe Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu 
    210                 215                 220                 


Gly Leu Asp Ser Thr Arg Thr Gly His His 
225                 230                 


<210>  14
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T278 3' TALEN FokI KKR Sharkey Amino Acid Sequence; shaded 
       portion refers to the protein coding region open reading frame

<400>  14

Val Ala Gly Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser 
1               5                   10                  15      


Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu 
            20                  25                  30          


Ile Glu Ile Ala Arg Asn Pro Thr Gln Asp Arg Ile Leu Glu Met Glu 
        35                  40                  45              


Thr Lys Val Met Glu Thr Glu Phe Phe Met Glu Thr Lys Val Tyr Gly 
    50                  55                  60                  


Tyr Arg Gly Glu His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile 
65                  70                  75                  80  


Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys 
                85                  90                  95      


Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met 
            100                 105                 110         


Glu Thr Gln Arg Tyr Val Lys Glu Asn Gln Thr Arg Asn Lys His Ile 
        115                 120                 125             


Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe 
    130                 135                 140                 


Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln 
145                 150                 155                 160 


Leu Thr Arg Leu Asn Arg Lys Thr Asn Cys Asn Gly Ala Val Leu Ser 
                165                 170                 175     


Val Glu Glu Leu Leu Ile Gly Gly Glu Met Glu Thr Ile Lys Ala Gly 
            180                 185                 190         


Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile 
        195                 200                 205             


Asn Phe Leu Gly Pro Phe Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu 
    210                 215                 220                 


Gly Leu Asp Ser Thr Arg Thr Gly His His 
225                 230                 


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer U3BamHI75F

<400>  15
cagctggatc ctgattggca g                                                 21


<210>  16
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer GagSalI804Rev

<400>  16
gggtgcgaga gcgtcgacga cgg                                               23


<210>  17
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  randomized reverse primer; Random5'siteRev


<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is a, c, g, or t

<400>  17
caggctcnna tctggtcnnn cna                                               23


<210>  18
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  randomized forward primer; Random5'siteFor


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  n is a, c, g, or t

<400>  18
ctctngnnng accagatnng agc                                               23


<210>  19
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer pBSNY5For

<400>  19
ggcatgctcg agctcagatg ctgcatat                                          28


<210>  20
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer pBSNY5Rev

<400>  20
catgcctcta gaagtgggtt ccctagc                                           27


<210>  21
<211>  3210
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5'TALEN.ELD.Sharkey DNA sequence (From start codon to stop codon)

<400>  21
atggactaca aagaccatga cggtgattat aaagatcatg acatcgatta caaggatgac       60

gatgacaaga tggcccccaa gaagaagagg aaggtgggca ttcaccgcgg ggtacctatg      120

gtggacttga ggacactcgg ttattcgcaa cagcaacagg agaaaatcaa gcctaaggtc      180

aggagcaccg tcgcgcaaca ccacgaggcg cttgtggggc atggcttcac tcatgcgcat      240

attgtcgcgc tttcacagca ccctgcggcg cttgggacgg tggctgtcaa ataccaagat      300

atgattgcgg ccctgcccga agccacgcac gaggcaattg taggggtcgg taaacagtgg      360

tcgggagcgc gagcacttga ggcgctgctg actgtggcgg gtgagcttag ggggcctccg      420

ctccagctcg acaccgggca gctgctgaag atcgcgaaga gagggggagt aacagcggta      480

gaggcagtgc acgcctggcg caatgcgctc accggggccc ccttgaacct gaccccagac      540

caggtagtcg caatcgcgtc acatgacggg ggaaagcaag ccctggaaac cgtgcaaagg      600

ttgttgccgg tcctttgtca agaccacggc cttacaccgg agcaagtcgt ggccattgca      660

agcaatgggg gtggcaaaca ggctcttgag acggttcaga gacttctccc agttctctgt      720

caagcccacg ggctgactcc cgatcaagtt gtagcgattg cgtcgcatga cggagggaaa      780

caagcattgg agactgtcca acggctcctt cccgtgttgt gtcaagccca cggtttgacg      840

cctgcacaag tggtcgccat cgcctcgaat ggcggcggta agcaggcgct ggaaacagta      900

cagcgcctgc tgcctgtact gtgccaggat catggactga ccccagacca ggtagtcgca      960

atcgcgaaca ataatggggg aaagcaagcc ctggaaaccg tgcaaaggtt gttgccggtc     1020

ctttgtcaag accacggcct tacaccggag caagtcgtgg ccattgcaaa taataacggt     1080

ggcaaacagg ctcttgagac ggttcagaga cttctcccag ttctctgtca agcccacggg     1140

ctgactcccg atcaagttgt agcgattgcg tccaacggtg gagggaaaca agcattggag     1200

actgtccaac ggctccttcc cgtgttgtgt caagcccacg gtttgacgcc tgcacaagtg     1260

gtcgccatcg cctcgaatgg cggcggtaag caggcgctgg aaacagtaca gcgcctgctg     1320

cctgtactgt gccaggatca tggactgact cccgatcaag ttgtagcgat tgcgtcgaac     1380

attggaggga aacaagcatt ggagactgtc caacggctcc ttcccgtgtt gtgtcaagcc     1440

cacggtctta caccggagca agtcgtggcc attgcaaata ataacggtgg caaacaggct     1500

cttgagacgg ttcagagact tctcccagtt ctctgtcaag cccacgggct gactcccgat     1560

caagttgtag cgattgcgtc gaacattgga gggaaacaag cattggagac tgtccaacgg     1620

ctccttcccg tgttgtgtca agcccacggt ttgacgcctg cacaagtggt cgccatcgcc     1680

agccatgatg gcggtaagca ggcgctggaa acagtacagc gcctgctgcc tgtactgtgc     1740

caggatcatg gactgacccc agaccaggta gtcgcaatcg cgtcacatga cgggggaaag     1800

caagccctgg aaaccgtgca aaggttgttg ccggtccttt gtcaagacca cggccttaca     1860

ccggagcaag tcgtggccat tgcaagcaac atcggtggca aacaggctct tgagacggtt     1920

cagagacttc tcccagttct ctgtcaagcc cacgggctga ctcccgatca agttgtagcg     1980

attgcgaata acaatggagg gaaacaagca ttggagactg tccaacggct ccttcccgtg     2040

ttgtgtcaag cccacggttt gacgcctgca caagtggtcg ccatcgcctc caatattggc     2100

ggtaagcagg cgctggaaac agtacagcgc ctgctgcctg tactgtgcca ggatcatgga     2160

ctgaccccag accaggtagt cgcaatcgcg tcaaacggag ggggaaagca agccctggaa     2220

accgtgcaaa ggttgttgcc ggtcctttgt caagaccacg gccttacacc ggagcaagtc     2280

gtggccattg catcccacga cggtggcaaa caggctcttg agacggttca gagacttctc     2340

ccagttctct gtcaagccca cgggctgaca cccgaacagg tggtcgccat tgcttctaat     2400

gggggaggac ggccagcctt ggagtccatc gtagcccaat tgtccaggcc cgatcccgcg     2460

ttggctgcgt taacgaatga ccatctggtg gcgttggcat gtcttggtgg acgacccgcg     2520

ctcgatgcag tcaaaaaggg tctgcctcat gctcccgcat tgatcaaaag aaccaaccgg     2580

cggattcccg agagaacttc ccatcgagtc gcgggatccc aactagtcaa aagtgaactg     2640

gaggagaaga aatctgaact tcgtcataaa ttgaaatatg tgcctcatga atatattgaa     2700

ttaattgaaa ttgccagaaa tcccactcag gatagaattc ttgaaatgaa ggtaatggaa     2760

ttttttatga aagtttatgg atatagaggt gagcatttgg gtggatcaag gaaaccggac     2820

ggagcaattt atactgtcgg atctcctatt gattacggtg tgatcgtgga tactaaagct     2880

tatagcggag gttataatct gccaattggc caagcagatg aaatggagcg atatgtcgaa     2940

gaaaatcaaa cacgagacaa acatctgaac cctaatgaat ggtggaaagt ctatccatct     3000

tctgtaacgg aatttaagtt tttatttgtg agtggtcact ttaaaggaaa ctacaaagct     3060

cagcttacac gattaaatca tatcactaat tgtaatggag ctgttcttag tgtagaagag     3120

cttttaattg gtggagaaat gattaaagcc ggcacattaa ccttagagga agtcagacgg     3180

aaatttaata acggcgagat aaacttttaa                                      3210


<210>  22
<211>  7359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  JDS78 (with 5'TALEN.ELD.Sharkey)

<400>  22
atggactaca aagaccatga cggtgattat aaagatcatg acatcgatta caaggatgac       60

gatgacaaga tggcccccaa gaagaagagg aaggtgggca ttcaccgcgg ggtacctatg      120

gtggacttga ggacactcgg ttattcgcaa cagcaacagg agaaaatcaa gcctaaggtc      180

aggagcaccg tcgcgcaaca ccacgaggcg cttgtggggc atggcttcac tcatgcgcat      240

attgtcgcgc tttcacagca ccctgcggcg cttgggacgg tggctgtcaa ataccaagat      300

atgattgcgg ccctgcccga agccacgcac gaggcaattg taggggtcgg taaacagtgg      360

tcgggagcgc gagcacttga ggcgctgctg actgtggcgg gtgagcttag ggggcctccg      420

ctccagctcg acaccgggca gctgctgaag atcgcgaaga gagggggagt aacagcggta      480

gaggcagtgc acgcctggcg caatgcgctc accggggccc ccttgaacct gaccccagac      540

caggtagtcg caatcgcgtc acatgacggg ggaaagcaag ccctggaaac cgtgcaaagg      600

ttgttgccgg tcctttgtca agaccacggc cttacaccgg agcaagtcgt ggccattgca      660

agcaatgggg gtggcaaaca ggctcttgag acggttcaga gacttctccc agttctctgt      720

caagcccacg ggctgactcc cgatcaagtt gtagcgattg cgtcgcatga cggagggaaa      780

caagcattgg agactgtcca acggctcctt cccgtgttgt gtcaagccca cggtttgacg      840

cctgcacaag tggtcgccat cgcctcgaat ggcggcggta agcaggcgct ggaaacagta      900

cagcgcctgc tgcctgtact gtgccaggat catggactga ccccagacca ggtagtcgca      960

atcgcgaaca ataatggggg aaagcaagcc ctggaaaccg tgcaaaggtt gttgccggtc     1020

ctttgtcaag accacggcct tacaccggag caagtcgtgg ccattgcaaa taataacggt     1080

ggcaaacagg ctcttgagac ggttcagaga cttctcccag ttctctgtca agcccacggg     1140

ctgactcccg atcaagttgt agcgattgcg tccaacggtg gagggaaaca agcattggag     1200

actgtccaac ggctccttcc cgtgttgtgt caagcccacg gtttgacgcc tgcacaagtg     1260

gtcgccatcg cctcgaatgg cggcggtaag caggcgctgg aaacagtaca gcgcctgctg     1320

cctgtactgt gccaggatca tggactgact cccgatcaag ttgtagcgat tgcgtcgaac     1380

attggaggga aacaagcatt ggagactgtc caacggctcc ttcccgtgtt gtgtcaagcc     1440

cacggtctta caccggagca agtcgtggcc attgcaaata ataacggtgg caaacaggct     1500

cttgagacgg ttcagagact tctcccagtt ctctgtcaag cccacgggct gactcccgat     1560

caagttgtag cgattgcgtc gaacattgga gggaaacaag cattggagac tgtccaacgg     1620

ctccttcccg tgttgtgtca agcccacggt ttgacgcctg cacaagtggt cgccatcgcc     1680

agccatgatg gcggtaagca ggcgctggaa acagtacagc gcctgctgcc tgtactgtgc     1740

caggatcatg gactgacccc agaccaggta gtcgcaatcg cgtcacatga cgggggaaag     1800

caagccctgg aaaccgtgca aaggttgttg ccggtccttt gtcaagacca cggccttaca     1860

ccggagcaag tcgtggccat tgcaagcaac atcggtggca aacaggctct tgagacggtt     1920

cagagacttc tcccagttct ctgtcaagcc cacgggctga ctcccgatca agttgtagcg     1980

attgcgaata acaatggagg gaaacaagca ttggagactg tccaacggct ccttcccgtg     2040

ttgtgtcaag cccacggttt gacgcctgca caagtggtcg ccatcgcctc caatattggc     2100

ggtaagcagg cgctggaaac agtacagcgc ctgctgcctg tactgtgcca ggatcatgga     2160

ctgaccccag accaggtagt cgcaatcgcg tcaaacggag ggggaaagca agccctggaa     2220

accgtgcaaa ggttgttgcc ggtcctttgt caagaccacg gccttacacc ggagcaagtc     2280

gtggccattg catcccacga cggtggcaaa caggctcttg agacggttca gagacttctc     2340

ccagttctct gtcaagccca cgggctgaca cccgaacagg tggtcgccat tgcttctaat     2400

gggggaggac ggccagcctt ggagtccatc gtagcccaat tgtccaggcc cgatcccgcg     2460

ttggctgcgt taacgaatga ccatctggtg gcgttggcat gtcttggtgg acgacccgcg     2520

ctcgatgcag tcaaaaaggg tctgcctcat gctcccgcat tgatcaaaag aaccaaccgg     2580

cggattcccg agagaacttc ccatcgagtc gcgggatccc aactagtcaa aagtgaactg     2640

gaggagaaga aatctgaact tcgtcataaa ttgaaatatg tgcctcatga atatattgaa     2700

ttaattgaaa ttgccagaaa tcccactcag gatagaattc ttgaaatgaa ggtaatggaa     2760

ttttttatga aagtttatgg atatagaggt gagcatttgg gtggatcaag gaaaccggac     2820

ggagcaattt atactgtcgg atctcctatt gattacggtg tgatcgtgga tactaaagct     2880

tatagcggag gttataatct gccaattggc caagcagatg aaatggagcg atatgtcgaa     2940

gaaaatcaaa cacgagacaa acatctgaac cctaatgaat ggtggaaagt ctatccatct     3000

tctgtaacgg aatttaagtt tttatttgtg agtggtcact ttaaaggaaa ctacaaagct     3060

cagcttacac gattaaatca tatcactaat tgtaatggag ctgttcttag tgtagaagag     3120

cttttaattg gtggagaaat gattaaagcc ggcacattaa ccttagagga agtcagacgg     3180

aaatttaata acggcgagat aaacttttaa gggcccttcg aaggtaagcc tatccctaac     3240

cctctcctcg gtctcgattc tacgcgtacc ggtcatcatc accatcacca ttgagtttaa     3300

acccgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt ttgcccctcc     3360

cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag     3420

gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag     3480

gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc ggtgggctct     3540

atggcttctg aggcggaaag aaccagctgg ggctctaggg ggtatcccca cgcgccctgt     3600

agcggcgcat taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc     3660

agcgccctag cgcccgctcc tttcgctttc ttcccttcct ttctcgccac gttcgccggc     3720

tttccccgtc aagctctaaa tcggggcatc cctttagggt tccgatttag tgctttacgg     3780

cacctcgacc ccaaaaaact tgattagggt gatggttcac gtagtgggcc atcgccctga     3840

tagacggttt ttcgcccttt gacgttggag tccacgttct ttaatagtgg actcttgttc     3900

caaactggaa caacactcaa ccctatctcg gtctattctt ttgatttata agggattttg     3960

gggatttcgg cctattggtt aaaaaatgag ctgatttaac aaaaatttaa cgcgaattaa     4020

ttctgtggaa tgtgtgtcag ttagggtgtg gaaagtcccc aggctcccca ggcaggcaga     4080

agtatgcaaa gcatgcatct caattagtca gcaaccaggt gtggaaagtc cccaggctcc     4140

ccagcaggca gaagtatgca aagcatgcat ctcaattagt cagcaaccat agtcccgccc     4200

ctaactccgc ccatcccgcc cctaactccg cccagttccg cccattctcc gccccatggc     4260

tgactaattt tttttattta tgcagaggcc gaggccgcct ctgcctctga gctattccag     4320

aagtagtgag gaggcttttt tggaggccta ggcttttgca aaaagctccc gggagcttgt     4380

atatccattt tcggatctga tcagcacgtg ttgacaatta atcatcggca tagtatatcg     4440

gcatagtata atacgacaag gtgaggaact aaaccatggc caagcctttg tctcaagaag     4500

aatccaccct cattgaaaga gcaacggcta caatcaacag catccccatc tctgaagact     4560

acagcgtcgc cagcgcagct ctctctagcg acggccgcat cttcactggt gtcaatgtat     4620

atcattttac tgggggacct tgtgcagaac tcgtggtgct gggcactgct gctgctgcgg     4680

cagctggcaa cctgacttgt atcgtcgcga tcggaaatga gaacaggggc atcttgagcc     4740

cctgcggacg gtgtcgacag gtgcttctcg atctgcatcc tgggatcaaa gcgatagtga     4800

aggacagtga tggacagccg acggcagttg ggattcgtga attgctgccc tctggttatg     4860

tgtgggaggg ctaagcactt cgtggccgag gagcaggact gacacgtgct acgagatttc     4920

gattccaccg ccgccttcta tgaaaggttg ggcttcggaa tcgttttccg ggacgccggc     4980

tggatgatcc tccagcgcgg ggatctcatg ctggagttct tcgcccaccc caacttgttt     5040

attgcagctt ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca     5100

tttttttcac tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc     5160

tgtataccgt cgacctctag ctagagcttg gcgtaatcat ggtcatagct gtttcctgtg     5220

tgaaattgtt atccgctcac aattccacac aacatacgag ccggaagcat aaagtgtaaa     5280

gcctggggtg cctaatgagt gagctaactc acattaattg cgttgcgctc actgcccgct     5340

ttccagtcgg gaaacctgtc gtgccagctg cattaatgaa tcggccaacg cgcggggaga     5400

ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct gcgctcggtc     5460

gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt atccacagaa     5520

tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt     5580

aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa     5640

aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt     5700

ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg     5760

tccgcctttc tcccttcggg aagcgtggcg ctttctcaat gctcacgctg taggtatctc     5820

agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc     5880

gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta     5940

tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct     6000

acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt atttggtatc     6060

tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa     6120

caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa     6180

aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa     6240

aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt     6300

ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac ttggtctgac     6360

agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt tcgttcatcc     6420

atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt accatctggc     6480

cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt atcagcaata     6540

aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc cgcctccatc     6600

cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc     6660

aacgttgttg ccattgctac aggcatcgtg gtgtcacgct cgtcgtttgg tatggcttca     6720

ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt gtgcaaaaaa     6780

gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc agtgttatca     6840

ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt aagatgcttt     6900

tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg gcgaccgagt     6960

tgctcttgcc cggcgtcaat acgggataat accgcgccac atagcagaac tttaaaagtg     7020

ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc gctgttgaga     7080

tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt tactttcacc     7140

agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg aataagggcg     7200

acacggaaat gttgaatact catactcttc ctttttcaat attattgaag catttatcag     7260

ggttattgtc tcatgagcgg atacatattt gaatgtattt agaaaaataa acaaataggg     7320

gttccgcgca catttccccg aaaagtgcca cctgacgtc                            7359


<210>  23
<211>  6447
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  JDS78

<400>  23
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gctggctagc      900

accatggact acaaagacca tgacggtgat tataaagatc atgacatcga ttacaaggat      960

gacgatgaca agatggcccc caagaagaag aggaaggtgg gcattcaccg cggggtacct     1020

atggtggact tgaggacact cggttattcg caacagcaac aggagaaaat caagcctaag     1080

gtcaggagca ccgtcgcgca acaccacgag gcgcttgtgg ggcatggctt cactcatgcg     1140

catattgtcg cgctttcaca gcaccctgcg gcgcttggga cggtggctgt caaataccaa     1200

gatatgattg cggccctgcc cgaagccacg cacgaggcaa ttgtaggggt cggtaaacag     1260

tggtcgggag cgcgagcact tgaggcgctg ctgactgtgg cgggtgagct tagggggcct     1320

ccgctccagc tcgacaccgg gcagctgctg aagatcgcga agagaggggg agtaacagcg     1380

gtagaggcag tgcacgcctg gcgcaatgcg ctcaccgggg cccccttgaa cagagacgat     1440

taatgcgtct cgctgacacc cgaacaggtg gtcgccattg cttctaatgg gggaggacgg     1500

ccagccttgg agtccatcgt agcccaattg tccaggcccg atcccgcgtt ggctgcgtta     1560

acgaatgacc atctggtggc gttggcatgt cttggtggac gacccgcgct cgatgcagtc     1620

aaaaagggtc tgcctcatgc tcccgcattg atcaaaagaa ccaaccggcg gattcccgag     1680

agaacttccc atcgagtcgc gggatcccaa ctagtcaaaa gtgaactgga ggagaagaaa     1740

tctgaacttc gtcataaatt gaaatatgtg cctcatgaat atattgaatt aattgaaatt     1800

gccagaaatt ccactcagga tagaattctt gaaatgaagg taatggaatt ttttatgaaa     1860

gtttatggat atagaggtaa acatttgggt ggatcaagga aaccggacgg agcaatttat     1920

actgtcggat ctcctattga ttacggtgtg atcgtggata ctaaagctta tagcggaggt     1980

tataatctgc caattggcca agcagatgaa atgcaacgat atgtcgaaga aaatcaaaca     2040

cgaaacaaac atatcaaccc taatgaatgg tggaaagtct atccatcttc tgtaacggaa     2100

tttaagtttt tatttgtgag tggtcacttt aaaggaaact acaaagctca gcttacacga     2160

ttaaatcata tcactaattg taatggagct gttcttagtg tagaagagct tttaattggt     2220

ggagaaatga ttaaagccgg cacattaacc ttagaggaag tcagacggaa atttaataac     2280

ggcgagataa acttttaagg gcccttcgaa ggtaagccta tccctaaccc tctcctcggt     2340

ctcgattcta cgcgtaccgg tcatcatcac catcaccatt gagtttaaac ccgctgatca     2400

gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc     2460

ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg     2520

cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg     2580

gaggattggg aagacaatag caggcatgct ggggatgcgg tgggctctat ggcttctgag     2640

gcggaaagaa ccagctgggg ctctaggggg tatccccacg cgccctgtag cggcgcatta     2700

agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg     2760

cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa     2820

gctctaaatc ggggcatccc tttagggttc cgatttagtg ctttacggca cctcgacccc     2880

aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt     2940

cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca     3000

acactcaacc ctatctcggt ctattctttt gatttataag ggattttggg gatttcggcc     3060

tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattaatt ctgtggaatg     3120

tgtgtcagtt agggtgtgga aagtccccag gctccccagg caggcagaag tatgcaaagc     3180

atgcatctca attagtcagc aaccaggtgt ggaaagtccc caggctcccc agcaggcaga     3240

agtatgcaaa gcatgcatct caattagtca gcaaccatag tcccgcccct aactccgccc     3300

atcccgcccc taactccgcc cagttccgcc cattctccgc cccatggctg actaattttt     3360

tttatttatg cagaggccga ggccgcctct gcctctgagc tattccagaa gtagtgagga     3420

ggcttttttg gaggcctagg cttttgcaaa aagctcccgg gagcttgtat atccattttc     3480

ggatctgatc agcacgtgtt gacaattaat catcggcata gtatatcggc atagtataat     3540

acgacaaggt gaggaactaa accatggcca agcctttgtc tcaagaagaa tccaccctca     3600

ttgaaagagc aacggctaca atcaacagca tccccatctc tgaagactac agcgtcgcca     3660

gcgcagctct ctctagcgac ggccgcatct tcactggtgt caatgtatat cattttactg     3720

ggggaccttg tgcagaactc gtggtgctgg gcactgctgc tgctgcggca gctggcaacc     3780

tgacttgtat cgtcgcgatc ggaaatgaga acaggggcat cttgagcccc tgcggacggt     3840

gtcgacaggt gcttctcgat ctgcatcctg ggatcaaagc gatagtgaag gacagtgatg     3900

gacagccgac ggcagttggg attcgtgaat tgctgccctc tggttatgtg tgggagggct     3960

aagcacttcg tggccgagga gcaggactga cacgtgctac gagatttcga ttccaccgcc     4020

gccttctatg aaaggttggg cttcggaatc gttttccggg acgccggctg gatgatcctc     4080

cagcgcgggg atctcatgct ggagttcttc gcccacccca acttgtttat tgcagcttat     4140

aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg     4200

cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg tataccgtcg     4260

acctctagct agagcttggc gtaatcatgg tcatagctgt ttcctgtgtg aaattgttat     4320

ccgctcacaa ttccacacaa catacgagcc ggaagcataa agtgtaaagc ctggggtgcc     4380

taatgagtga gctaactcac attaattgcg ttgcgctcac tgcccgcttt ccagtcggga     4440

aacctgtcgt gccagctgca ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt     4500

attgggcgct cttccgcttc ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg     4560

cgagcggtat cagctcactc aaaggcggta atacggttat ccacagaatc aggggataac     4620

gcaggaaaga acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg     4680

ttgctggcgt ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca     4740

agtcagaggt ggcgaaaccc gacaggacta taaagatacc aggcgtttcc ccctggaagc     4800

tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg gatacctgtc cgcctttctc     4860

ccttcgggaa gcgtggcgct ttctcaatgc tcacgctgta ggtatctcag ttcggtgtag     4920

gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc     4980

ttatccggta actatcgtct tgagtccaac ccggtaagac acgacttatc gccactggca     5040

gcagccactg gtaacaggat tagcagagcg aggtatgtag gcggtgctac agagttcttg     5100

aagtggtggc ctaactacgg ctacactaga aggacagtat ttggtatctg cgctctgctg     5160

aagccagtta ccttcggaaa aagagttggt agctcttgat ccggcaaaca aaccaccgct     5220

ggtagcggtg gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa     5280

gaagatcctt tgatcttttc tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa     5340

gggattttgg tcatgagatt atcaaaaagg atcttcacct agatcctttt aaattaaaaa     5400

tgaagtttta aatcaatcta aagtatatat gagtaaactt ggtctgacag ttaccaatgc     5460

ttaatcagtg aggcacctat ctcagcgatc tgtctatttc gttcatccat agttgcctga     5520

ctccccgtcg tgtagataac tacgatacgg gagggcttac catctggccc cagtgctgca     5580

atgataccgc gagacccacg ctcaccggct ccagatttat cagcaataaa ccagccagcc     5640

ggaagggccg agcgcagaag tggtcctgca actttatccg cctccatcca gtctattaat     5700

tgttgccggg aagctagagt aagtagttcg ccagttaata gtttgcgcaa cgttgttgcc     5760

attgctacag gcatcgtggt gtcacgctcg tcgtttggta tggcttcatt cagctccggt     5820

tcccaacgat caaggcgagt tacatgatcc cccatgttgt gcaaaaaagc ggttagctcc     5880

ttcggtcctc cgatcgttgt cagaagtaag ttggccgcag tgttatcact catggttatg     5940

gcagcactgc ataattctct tactgtcatg ccatccgtaa gatgcttttc tgtgactggt     6000

gagtactcaa ccaagtcatt ctgagaatag tgtatgcggc gaccgagttg ctcttgcccg     6060

gcgtcaatac gggataatac cgcgccacat agcagaactt taaaagtgct catcattgga     6120

aaacgttctt cggggcgaaa actctcaagg atcttaccgc tgttgagatc cagttcgatg     6180

taacccactc gtgcacccaa ctgatcttca gcatctttta ctttcaccag cgtttctggg     6240

tgagcaaaaa caggaaggca aaatgccgca aaaaagggaa taagggcgac acggaaatgt     6300

tgaatactca tactcttcct ttttcaatat tattgaagca tttatcaggg ttattgtctc     6360

atgagcggat acatatttga atgtatttag aaaaataaac aaataggggt tccgcgcaca     6420

tttccccgaa aagtgccacc tgacgtc                                         6447


<210>  24
<211>  3414
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3'TALEN (in JDS70) Constructs T278

<400>  24
atggactaca aagaccatga cggtgattat aaagatcatg acatcgatta caaggatgac       60

gatgacaaga tggcccccaa gaagaagagg aaggtgggca ttcaccgcgg ggtacctatg      120

gtggacttga ggacactcgg ttattcgcaa cagcaacagg agaaaatcaa gcctaaggtc      180

aggagcaccg tcgcgcaaca ccacgaggcg cttgtggggc atggcttcac tcatgcgcat      240

attgtcgcgc tttcacagca ccctgcggcg cttgggacgg tggctgtcaa ataccaagat      300

atgattgcgg ccctgcccga agccacgcac gaggcaattg taggggtcgg taaacagtgg      360

tcgggagcgc gagcacttga ggcgctgctg actgtggcgg gtgagcttag ggggcctccg      420

ctccagctcg acaccgggca gctgctgaag atcgcgaaga gagggggagt aacagcggta      480

gaggcagtgc acgcctggcg caatgcgctc accggggccc ccttgaacct gaccccagac      540

caggtagtcg caatcgcgtc gaacattggg ggaaagcaag ccctggaaac cgtgcaaagg      600

ttgttgccgg tcctttgtca agaccacggc cttacaccgg agcaagtcgt ggccattgca      660

agcaacatcg gtggcaaaca ggctcttgag acggttcaga gacttctccc agttctctgt      720

caagcccacg ggctgactcc cgatcaagtt gtagcgattg cgaataacaa tggagggaaa      780

caagcattgg agactgtcca acggctcctt cccgtgttgt gtcaagccca cggtttgacg      840

cctgcacaag tggtcgccat cgccagccat gatggcggta agcaggcgct ggaaacagta      900

cagcgcctgc tgcctgtact gtgccaggat catggactga ccccagacca ggtagtcgca      960

atcgcgtcga acattggggg aaagcaagcc ctggaaaccg tgcaaaggtt gttgccggtc     1020

ctttgtcaag accacggcct tacaccggag caagtcgtgg ccattgcaaa taataacggt     1080

ggcaaacagg ctcttgagac ggttcagaga cttctcccag ttctctgtca agcccacggg     1140

ctgactcccg atcaagttgt agcgattgcg tccaacggtg gagggaaaca agcattggag     1200

actgtccaac ggctccttcc cgtgttgtgt caagcccacg gtttgacgcc tgcacaagtg     1260

gtcgccatcg ccaacaacaa cggcggtaag caggcgctgg aaacagtaca gcgcctgctg     1320

cctgtactgt gccaggatca tggactgacc ccagaccagg tagtcgcaat cgcgaacaat     1380

aatgggggaa agcaagccct ggaaaccgtg caaaggttgt tgccggtcct ttgtcaagac     1440

cacggcctta caccggagca agtcgtggcc attgcaaata ataacggtgg caaacaggct     1500

cttgagacgg ttcagagact tctcccagtt ctctgtcaag cccacgggct gactcccgat     1560

caagttgtag cgattgcgtc caacggtgga gggaaacaag cattggagac tgtccaacgg     1620

ctccttcccg tgttgtgtca agcccacggt ttgacgcctg cacaagtggt cgccatcgcc     1680

tcgaatggcg gcggtaagca ggcgctggaa acagtacagc gcctgctgcc tgtactgtgc     1740

caggatcatg gactgacccc agaccaggta gtcgcaatcg cgtcacatga cgggggaaag     1800

caagccctgg aaaccgtgca aaggttgttg ccggtccttt gtcaagacca cggccttaca     1860

ccggagcaag tcgtggccat tgcatcccac gacggtggca aacaggctct tgagacggtt     1920

cagagacttc tcccagttct ctgtcaagcc cacgggctga ctcccgatca agttgtagcg     1980

attgcgtcgc atgacggagg gaaacaagca ttggagactg tccaacggct ccttcccgtg     2040

ttgtgtcaag cccacggttt gacgcctgca caagtggtcg ccatcgcctc gaatggcggc     2100

ggtaagcagg cgctggaaac agtacagcgc ctgctgcctg tactgtgcca ggatcatgga     2160

ctgaccccag accaggtagt cgcaatcgcg tcgaacattg ggggaaagca agccctggaa     2220

accgtgcaaa ggttgttgcc ggtcctttgt caagaccacg gccttacacc ggagcaagtc     2280

gtggccattg caaataataa cggtggcaaa caggctcttg agacggttca gagacttctc     2340

ccagttctct gtcaagccca cgggctgact cccgatcaag ttgtagcgat tgcgtccaac     2400

ggtggaggga aacaagcatt ggagactgtc caacggctcc ttcccgtgtt gtgtcaagcc     2460

cacggtttga cgcctgcaca agtggtcgcc atcgcctcga atggcggcgg taagcaggcg     2520

ctggaaacag tacagcgcct gctgcctgta ctgtgccagg atcatggact gacacccgaa     2580

caggtggtcg ccattgcttc taacatcgga ggacggccag ccttggagtc catcgtagcc     2640

caattgtcca ggcccgatcc cgcgttggct gcgttaacga atgaccatct ggtggcgttg     2700

gcatgtcttg gtggacgacc cgcgctcgat gcagtcaaaa agggtctgcc tcatgctccc     2760

gcattgatca aaagaaccaa ccggcggatt cccgagagaa cttcccatcg agtcgcggga     2820

tcccaactag tcaaaagtga actggaggag aagaaatctg aacttcgtca taaattgaaa     2880

tatgtgcctc atgaatatat tgaattaatt gaaattgcca gaaattccac tcaggataga     2940

attcttgaaa tgaaggtaat ggaatttttt atgaaagttt atggatatag aggtaaacat     3000

ttgggtggat caaggaaacc ggacggagca atttatactg tcggatctcc tattgattac     3060

ggtgtgatcg tggatactaa agcttatagc ggaggttata atctgccaat tggccaagca     3120

gatgaaatgc aacgatatgt cgaagaaaat caaacacgaa acaaacatat caaccctaat     3180

gaatggtgga aagtctatcc atcttctgta acggaattta agtttttatt tgtgagtggt     3240

cactttaaag gaaactacaa agctcagctt acacgattaa atcatatcac taattgtaat     3300

ggagctgttc ttagtgtaga agagctttta attggtggag aaatgattaa agccggcaca     3360

ttaaccttag aggaagtcag acggaaattt aataacggcg agataaactt ttaa           3414


<210>  25
<211>  6447
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  JDS70

<400>  25
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gctggctagc      900

accatggact acaaagacca tgacggtgat tataaagatc atgacatcga ttacaaggat      960

gacgatgaca agatggcccc caagaagaag aggaaggtgg gcattcaccg cggggtacct     1020

atggtggact tgaggacact cggttattcg caacagcaac aggagaaaat caagcctaag     1080

gtcaggagca ccgtcgcgca acaccacgag gcgcttgtgg ggcatggctt cactcatgcg     1140

catattgtcg cgctttcaca gcaccctgcg gcgcttggga cggtggctgt caaataccaa     1200

gatatgattg cggccctgcc cgaagccacg cacgaggcaa ttgtaggggt cggtaaacag     1260

tggtcgggag cgcgagcact tgaggcgctg ctgactgtgg cgggtgagct tagggggcct     1320

ccgctccagc tcgacaccgg gcagctgctg aagatcgcga agagaggggg agtaacagcg     1380

gtagaggcag tgcacgcctg gcgcaatgcg ctcaccgggg cccccttgaa cagagacgat     1440

taatgcgtct cgctgacacc cgaacaggtg gtcgccattg cttctaacat cggaggacgg     1500

ccagccttgg agtccatcgt agcccaattg tccaggcccg atcccgcgtt ggctgcgtta     1560

acgaatgacc atctggtggc gttggcatgt cttggtggac gacccgcgct cgatgcagtc     1620

aaaaagggtc tgcctcatgc tcccgcattg atcaaaagaa ccaaccggcg gattcccgag     1680

agaacttccc atcgagtcgc gggatcccaa ctagtcaaaa gtgaactgga ggagaagaaa     1740

tctgaacttc gtcataaatt gaaatatgtg cctcatgaat atattgaatt aattgaaatt     1800

gccagaaatt ccactcagga tagaattctt gaaatgaagg taatggaatt ttttatgaaa     1860

gtttatggat atagaggtaa acatttgggt ggatcaagga aaccggacgg agcaatttat     1920

actgtcggat ctcctattga ttacggtgtg atcgtggata ctaaagctta tagcggaggt     1980

tataatctgc caattggcca agcagatgaa atgcaacgat atgtcgaaga aaatcaaaca     2040

cgaaacaaac atatcaaccc taatgaatgg tggaaagtct atccatcttc tgtaacggaa     2100

tttaagtttt tatttgtgag tggtcacttt aaaggaaact acaaagctca gcttacacga     2160

ttaaatcata tcactaattg taatggagct gttcttagtg tagaagagct tttaattggt     2220

ggagaaatga ttaaagccgg cacattaacc ttagaggaag tcagacggaa atttaataac     2280

ggcgagataa acttttaagg gcccttcgaa ggtaagccta tccctaaccc tctcctcggt     2340

ctcgattcta cgcgtaccgg tcatcatcac catcaccatt gagtttaaac ccgctgatca     2400

gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc     2460

ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg     2520

cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg     2580

gaggattggg aagacaatag caggcatgct ggggatgcgg tgggctctat ggcttctgag     2640

gcggaaagaa ccagctgggg ctctaggggg tatccccacg cgccctgtag cggcgcatta     2700

agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg     2760

cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa     2820

gctctaaatc ggggcatccc tttagggttc cgatttagtg ctttacggca cctcgacccc     2880

aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt     2940

cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca     3000

acactcaacc ctatctcggt ctattctttt gatttataag ggattttggg gatttcggcc     3060

tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattaatt ctgtggaatg     3120

tgtgtcagtt agggtgtgga aagtccccag gctccccagg caggcagaag tatgcaaagc     3180

atgcatctca attagtcagc aaccaggtgt ggaaagtccc caggctcccc agcaggcaga     3240

agtatgcaaa gcatgcatct caattagtca gcaaccatag tcccgcccct aactccgccc     3300

atcccgcccc taactccgcc cagttccgcc cattctccgc cccatggctg actaattttt     3360

tttatttatg cagaggccga ggccgcctct gcctctgagc tattccagaa gtagtgagga     3420

ggcttttttg gaggcctagg cttttgcaaa aagctcccgg gagcttgtat atccattttc     3480

ggatctgatc agcacgtgtt gacaattaat catcggcata gtatatcggc atagtataat     3540

acgacaaggt gaggaactaa accatggcca agcctttgtc tcaagaagaa tccaccctca     3600

ttgaaagagc aacggctaca atcaacagca tccccatctc tgaagactac agcgtcgcca     3660

gcgcagctct ctctagcgac ggccgcatct tcactggtgt caatgtatat cattttactg     3720

ggggaccttg tgcagaactc gtggtgctgg gcactgctgc tgctgcggca gctggcaacc     3780

tgacttgtat cgtcgcgatc ggaaatgaga acaggggcat cttgagcccc tgcggacggt     3840

gtcgacaggt gcttctcgat ctgcatcctg ggatcaaagc gatagtgaag gacagtgatg     3900

gacagccgac ggcagttggg attcgtgaat tgctgccctc tggttatgtg tgggagggct     3960

aagcacttcg tggccgagga gcaggactga cacgtgctac gagatttcga ttccaccgcc     4020

gccttctatg aaaggttggg cttcggaatc gttttccggg acgccggctg gatgatcctc     4080

cagcgcgggg atctcatgct ggagttcttc gcccacccca acttgtttat tgcagcttat     4140

aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg     4200

cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg tataccgtcg     4260

acctctagct agagcttggc gtaatcatgg tcatagctgt ttcctgtgtg aaattgttat     4320

ccgctcacaa ttccacacaa catacgagcc ggaagcataa agtgtaaagc ctggggtgcc     4380

taatgagtga gctaactcac attaattgcg ttgcgctcac tgcccgcttt ccagtcggga     4440

aacctgtcgt gccagctgca ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt     4500

attgggcgct cttccgcttc ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg     4560

cgagcggtat cagctcactc aaaggcggta atacggttat ccacagaatc aggggataac     4620

gcaggaaaga acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg     4680

ttgctggcgt ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca     4740

agtcagaggt ggcgaaaccc gacaggacta taaagatacc aggcgtttcc ccctggaagc     4800

tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg gatacctgtc cgcctttctc     4860

ccttcgggaa gcgtggcgct ttctcaatgc tcacgctgta ggtatctcag ttcggtgtag     4920

gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc     4980

ttatccggta actatcgtct tgagtccaac ccggtaagac acgacttatc gccactggca     5040

gcagccactg gtaacaggat tagcagagcg aggtatgtag gcggtgctac agagttcttg     5100

aagtggtggc ctaactacgg ctacactaga aggacagtat ttggtatctg cgctctgctg     5160

aagccagtta ccttcggaaa aagagttggt agctcttgat ccggcaaaca aaccaccgct     5220

ggtagcggtg gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa     5280

gaagatcctt tgatcttttc tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa     5340

gggattttgg tcatgagatt atcaaaaagg atcttcacct agatcctttt aaattaaaaa     5400

tgaagtttta aatcaatcta aagtatatat gagtaaactt ggtctgacag ttaccaatgc     5460

ttaatcagtg aggcacctat ctcagcgatc tgtctatttc gttcatccat agttgcctga     5520

ctccccgtcg tgtagataac tacgatacgg gagggcttac catctggccc cagtgctgca     5580

atgataccgc gagacccacg ctcaccggct ccagatttat cagcaataaa ccagccagcc     5640

ggaagggccg agcgcagaag tggtcctgca actttatccg cctccatcca gtctattaat     5700

tgttgccggg aagctagagt aagtagttcg ccagttaata gtttgcgcaa cgttgttgcc     5760

attgctacag gcatcgtggt gtcacgctcg tcgtttggta tggcttcatt cagctccggt     5820

tcccaacgat caaggcgagt tacatgatcc cccatgttgt gcaaaaaagc ggttagctcc     5880

ttcggtcctc cgatcgttgt cagaagtaag ttggccgcag tgttatcact catggttatg     5940

gcagcactgc ataattctct tactgtcatg ccatccgtaa gatgcttttc tgtgactggt     6000

gagtactcaa ccaagtcatt ctgagaatag tgtatgcggc gaccgagttg ctcttgcccg     6060

gcgtcaatac gggataatac cgcgccacat agcagaactt taaaagtgct catcattgga     6120

aaacgttctt cggggcgaaa actctcaagg atcttaccgc tgttgagatc cagttcgatg     6180

taacccactc gtgcacccaa ctgatcttca gcatctttta ctttcaccag cgtttctggg     6240

tgagcaaaaa caggaaggca aaatgccgca aaaaagggaa taagggcgac acggaaatgt     6300

tgaatactca tactcttcct ttttcaatat tattgaagca tttatcaggg ttattgtctc     6360

atgagcggat acatatttga atgtatttag aaaaataaac aaataggggt tccgcgcaca     6420

tttccccgaa aagtgccacc tgacgtc                                         6447


<210>  26
<211>  8466
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  JDS70 (with 3'TALEN)

<400>  26
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gctggctagc      900

accatggact acaaagacca tgacggtgat tataaagatc atgacatcga ttacaaggat      960

gacgatgaca agatggcccc caagaagaag aggaaggtgg gcattcaccg cggggtacct     1020

atggtggact tgaggacact cggttattcg caacagcaac aggagaaaat caagcctaag     1080

gtcaggagca ccgtcgcgca acaccacgag gcgcttgtgg ggcatggctt cactcatgcg     1140

catattgtcg cgctttcaca gcaccctgcg gcgcttggga cggtggctgt caaataccaa     1200

gatatgattg cggccctgcc cgaagccacg cacgaggcaa ttgtaggggt cggtaaacag     1260

tggtcgggag cgcgagcact tgaggcgctg ctgactgtgg cgggtgagct tagggggcct     1320

ccgctccagc tcgacaccgg gcagctgctg aagatcgcga agagaggggg agtaacagcg     1380

gtagaggcag tgcacgcctg gcgcaatgcg ctcaccgggg cccccttgaa cctgacccca     1440

gaccaggtag tcgcaatcgc gtcgaacatt gggggaaagc aagccctgga aaccgtgcaa     1500

aggttgttgc cggtcctttg tcaagaccac ggccttacac cggagcaagt cgtggccatt     1560

gcaagcaaca tcggtggcaa acaggctctt gagacggttc agagacttct cccagttctc     1620

tgtcaagccc acgggctgac tcccgatcaa gttgtagcga ttgcgaataa caatggaggg     1680

aaacaagcat tggagactgt ccaacggctc cttcccgtgt tgtgtcaagc ccacggtttg     1740

acgcctgcac aagtggtcgc catcgccagc catgatggcg gtaagcaggc gctggaaaca     1800

gtacagcgcc tgctgcctgt actgtgccag gatcatggac tgaccccaga ccaggtagtc     1860

gcaatcgcgt cgaacattgg gggaaagcaa gccctggaaa ccgtgcaaag gttgttgccg     1920

gtcctttgtc aagaccacgg ccttacaccg gagcaagtcg tggccattgc aaataataac     1980

ggtggcaaac aggctcttga gacggttcag agacttctcc cagttctctg tcaagcccac     2040

gggctgactc ccgatcaagt tgtagcgatt gcgtccaacg gtggagggaa acaagcattg     2100

gagactgtcc aacggctcct tcccgtgttg tgtcaagccc acggtttgac gcctgcacaa     2160

gtggtcgcca tcgccaacaa caacggcggt aagcaggcgc tggaaacagt acagcgcctg     2220

ctgcctgtac tgtgccagga tcatggactg accccagacc aggtagtcgc aatcgcgaac     2280

aataatgggg gaaagcaagc cctggaaacc gtgcaaaggt tgttgccggt cctttgtcaa     2340

gaccacggcc ttacaccgga gcaagtcgtg gccattgcaa ataataacgg tggcaaacag     2400

gctcttgaga cggttcagag acttctccca gttctctgtc aagcccacgg gctgactccc     2460

gatcaagttg tagcgattgc gtccaacggt ggagggaaac aagcattgga gactgtccaa     2520

cggctccttc ccgtgttgtg tcaagcccac ggtttgacgc ctgcacaagt ggtcgccatc     2580

gcctcgaatg gcggcggtaa gcaggcgctg gaaacagtac agcgcctgct gcctgtactg     2640

tgccaggatc atggactgac cccagaccag gtagtcgcaa tcgcgtcaca tgacggggga     2700

aagcaagccc tggaaaccgt gcaaaggttg ttgccggtcc tttgtcaaga ccacggcctt     2760

acaccggagc aagtcgtggc cattgcatcc cacgacggtg gcaaacaggc tcttgagacg     2820

gttcagagac ttctcccagt tctctgtcaa gcccacgggc tgactcccga tcaagttgta     2880

gcgattgcgt cgcatgacgg agggaaacaa gcattggaga ctgtccaacg gctccttccc     2940

gtgttgtgtc aagcccacgg tttgacgcct gcacaagtgg tcgccatcgc ctcgaatggc     3000

ggcggtaagc aggcgctgga aacagtacag cgcctgctgc ctgtactgtg ccaggatcat     3060

ggactgaccc cagaccaggt agtcgcaatc gcgtcgaaca ttgggggaaa gcaagccctg     3120

gaaaccgtgc aaaggttgtt gccggtcctt tgtcaagacc acggccttac accggagcaa     3180

gtcgtggcca ttgcaaataa taacggtggc aaacaggctc ttgagacggt tcagagactt     3240

ctcccagttc tctgtcaagc ccacgggctg actcccgatc aagttgtagc gattgcgtcc     3300

aacggtggag ggaaacaagc attggagact gtccaacggc tccttcccgt gttgtgtcaa     3360

gcccacggtt tgacgcctgc acaagtggtc gccatcgcct cgaatggcgg cggtaagcag     3420

gcgctggaaa cagtacagcg cctgctgcct gtactgtgcc aggatcatgg actgacaccc     3480

gaacaggtgg tcgccattgc ttctaacatc ggaggacggc cagccttgga gtccatcgta     3540

gcccaattgt ccaggcccga tcccgcgttg gctgcgttaa cgaatgacca tctggtggcg     3600

ttggcatgtc ttggtggacg acccgcgctc gatgcagtca aaaagggtct gcctcatgct     3660

cccgcattga tcaaaagaac caaccggcgg attcccgaga gaacttccca tcgagtcgcg     3720

ggatcccaac tagtcaaaag tgaactggag gagaagaaat ctgaacttcg tcataaattg     3780

aaatatgtgc ctcatgaata tattgaatta attgaaattg ccagaaattc cactcaggat     3840

agaattcttg aaatgaaggt aatggaattt tttatgaaag tttatggata tagaggtaaa     3900

catttgggtg gatcaaggaa accggacgga gcaatttata ctgtcggatc tcctattgat     3960

tacggtgtga tcgtggatac taaagcttat agcggaggtt ataatctgcc aattggccaa     4020

gcagatgaaa tgcaacgata tgtcgaagaa aatcaaacac gaaacaaaca tatcaaccct     4080

aatgaatggt ggaaagtcta tccatcttct gtaacggaat ttaagttttt atttgtgagt     4140

ggtcacttta aaggaaacta caaagctcag cttacacgat taaatcatat cactaattgt     4200

aatggagctg ttcttagtgt agaagagctt ttaattggtg gagaaatgat taaagccggc     4260

acattaacct tagaggaagt cagacggaaa tttaataacg gcgagataaa cttttaaggg     4320

cccttcgaag gtaagcctat ccctaaccct ctcctcggtc tcgattctac gcgtaccggt     4380

catcatcacc atcaccattg agtttaaacc cgctgatcag cctcgactgt gccttctagt     4440

tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact     4500

cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat     4560

tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc     4620

aggcatgctg gggatgcggt gggctctatg gcttctgagg cggaaagaac cagctggggc     4680

tctagggggt atccccacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt     4740

acgcgcagcg tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc     4800

ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg gggcatccct     4860

ttagggttcc gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat     4920

ggttcacgta gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc     4980

acgttcttta atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc     5040

tattcttttg atttataagg gattttgggg atttcggcct attggttaaa aaatgagctg     5100

atttaacaaa aatttaacgc gaattaattc tgtggaatgt gtgtcagtta gggtgtggaa     5160

agtccccagg ctccccaggc aggcagaagt atgcaaagca tgcatctcaa ttagtcagca     5220

accaggtgtg gaaagtcccc aggctcccca gcaggcagaa gtatgcaaag catgcatctc     5280

aattagtcag caaccatagt cccgccccta actccgccca tcccgcccct aactccgccc     5340

agttccgccc attctccgcc ccatggctga ctaatttttt ttatttatgc agaggccgag     5400

gccgcctctg cctctgagct attccagaag tagtgaggag gcttttttgg aggcctaggc     5460

ttttgcaaaa agctcccggg agcttgtata tccattttcg gatctgatca gcacgtgttg     5520

acaattaatc atcggcatag tatatcggca tagtataata cgacaaggtg aggaactaaa     5580

ccatggccaa gcctttgtct caagaagaat ccaccctcat tgaaagagca acggctacaa     5640

tcaacagcat ccccatctct gaagactaca gcgtcgccag cgcagctctc tctagcgacg     5700

gccgcatctt cactggtgtc aatgtatatc attttactgg gggaccttgt gcagaactcg     5760

tggtgctggg cactgctgct gctgcggcag ctggcaacct gacttgtatc gtcgcgatcg     5820

gaaatgagaa caggggcatc ttgagcccct gcggacggtg tcgacaggtg cttctcgatc     5880

tgcatcctgg gatcaaagcg atagtgaagg acagtgatgg acagccgacg gcagttggga     5940

ttcgtgaatt gctgccctct ggttatgtgt gggagggcta agcacttcgt ggccgaggag     6000

caggactgac acgtgctacg agatttcgat tccaccgccg ccttctatga aaggttgggc     6060

ttcggaatcg ttttccggga cgccggctgg atgatcctcc agcgcgggga tctcatgctg     6120

gagttcttcg cccaccccaa cttgtttatt gcagcttata atggttacaa ataaagcaat     6180

agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc     6240

aaactcatca atgtatctta tcatgtctgt ataccgtcga cctctagcta gagcttggcg     6300

taatcatggt catagctgtt tcctgtgtga aattgttatc cgctcacaat tccacacaac     6360

atacgagccg gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag ctaactcaca     6420

ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg ccagctgcat     6480

taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc ttccgcttcc     6540

tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc agctcactca     6600

aaggcggtaa tacggttatc cacagaatca ggggataacg caggaaagaa catgtgagca     6660

aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg     6720

ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg     6780

acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt     6840

ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt     6900

tctcaatgct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc     6960

tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt     7020

gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt     7080

agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc     7140

tacactagaa ggacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa     7200

agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt     7260

tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct     7320

acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta     7380

tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa     7440

agtatatatg agtaaacttg gtctgacagt taccaatgct taatcagtga ggcacctatc     7500

tcagcgatct gtctatttcg ttcatccata gttgcctgac tccccgtcgt gtagataact     7560

acgatacggg agggcttacc atctggcccc agtgctgcaa tgataccgcg agacccacgc     7620

tcaccggctc cagatttatc agcaataaac cagccagccg gaagggccga gcgcagaagt     7680

ggtcctgcaa ctttatccgc ctccatccag tctattaatt gttgccggga agctagagta     7740

agtagttcgc cagttaatag tttgcgcaac gttgttgcca ttgctacagg catcgtggtg     7800

tcacgctcgt cgtttggtat ggcttcattc agctccggtt cccaacgatc aaggcgagtt     7860

acatgatccc ccatgttgtg caaaaaagcg gttagctcct tcggtcctcc gatcgttgtc     7920

agaagtaagt tggccgcagt gttatcactc atggttatgg cagcactgca taattctctt     7980

actgtcatgc catccgtaag atgcttttct gtgactggtg agtactcaac caagtcattc     8040

tgagaatagt gtatgcggcg accgagttgc tcttgcccgg cgtcaatacg ggataatacc     8100

gcgccacata gcagaacttt aaaagtgctc atcattggaa aacgttcttc ggggcgaaaa     8160

ctctcaagga tcttaccgct gttgagatcc agttcgatgt aacccactcg tgcacccaac     8220

tgatcttcag catcttttac tttcaccagc gtttctgggt gagcaaaaac aggaaggcaa     8280

aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt gaatactcat actcttcctt     8340

tttcaatatt attgaagcat ttatcagggt tattgtctca tgagcggata catatttgaa     8400

tgtatttaga aaaataaaca aataggggtt ccgcgcacat ttccccgaaa agtgccacct     8460

gacgtc                                                                8466


<210>  27
<211>  3414
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3'TALEN.KKR.Sharkey DNA sequence (From start codon to stop codon)

<400>  27
atggactaca aagaccatga cggtgattat aaagatcatg acatcgatta caaggatgac       60

gatgacaaga tggcccccaa gaagaagagg aaggtgggca ttcaccgcgg ggtacctatg      120

gtggacttga ggacactcgg ttattcgcaa cagcaacagg agaaaatcaa gcctaaggtc      180

aggagcaccg tcgcgcaaca ccacgaggcg cttgtggggc atggcttcac tcatgcgcat      240

attgtcgcgc tttcacagca ccctgcggcg cttgggacgg tggctgtcaa ataccaagat      300

atgattgcgg ccctgcccga agccacgcac gaggcaattg taggggtcgg taaacagtgg      360

tcgggagcgc gagcacttga ggcgctgctg actgtggcgg gtgagcttag ggggcctccg      420

ctccagctcg acaccgggca gctgctgaag atcgcgaaga gagggggagt aacagcggta      480

gaggcagtgc acgcctggcg caatgcgctc accggggccc ccttgaacct gaccccagac      540

caggtagtcg caatcgcgtc gaacattggg ggaaagcaag ccctggaaac cgtgcaaagg      600

ttgttgccgg tcctttgtca agaccacggc cttacaccgg agcaagtcgt ggccattgca      660

agcaacatcg gtggcaaaca ggctcttgag acggttcaga gacttctccc agttctctgt      720

caagcccacg ggctgactcc cgatcaagtt gtagcgattg cgaataacaa tggagggaaa      780

caagcattgg agactgtcca acggctcctt cccgtgttgt gtcaagccca cggtttgacg      840

cctgcacaag tggtcgccat cgccagccat gatggcggta agcaggcgct ggaaacagta      900

cagcgcctgc tgcctgtact gtgccaggat catggactga ccccagacca ggtagtcgca      960

atcgcgtcga acattggggg aaagcaagcc ctggaaaccg tgcaaaggtt gttgccggtc     1020

ctttgtcaag accacggcct tacaccggag caagtcgtgg ccattgcaaa taataacggt     1080

ggcaaacagg ctcttgagac ggttcagaga cttctcccag ttctctgtca agcccacggg     1140

ctgactcccg atcaagttgt agcgattgcg tccaacggtg gagggaaaca agcattggag     1200

actgtccaac ggctccttcc cgtgttgtgt caagcccacg gtttgacgcc tgcacaagtg     1260

gtcgccatcg ccaacaacaa cggcggtaag caggcgctgg aaacagtaca gcgcctgctg     1320

cctgtactgt gccaggatca tggactgacc ccagaccagg tagtcgcaat cgcgaacaat     1380

aatgggggaa agcaagccct ggaaaccgtg caaaggttgt tgccggtcct ttgtcaagac     1440

cacggcctta caccggagca agtcgtggcc attgcaaata ataacggtgg caaacaggct     1500

cttgagacgg ttcagagact tctcccagtt ctctgtcaag cccacgggct gactcccgat     1560

caagttgtag cgattgcgtc caacggtgga gggaaacaag cattggagac tgtccaacgg     1620

ctccttcccg tgttgtgtca agcccacggt ttgacgcctg cacaagtggt cgccatcgcc     1680

tcgaatggcg gcggtaagca ggcgctggaa acagtacagc gcctgctgcc tgtactgtgc     1740

caggatcatg gactgacccc agaccaggta gtcgcaatcg cgtcacatga cgggggaaag     1800

caagccctgg aaaccgtgca aaggttgttg ccggtccttt gtcaagacca cggccttaca     1860

ccggagcaag tcgtggccat tgcatcccac gacggtggca aacaggctct tgagacggtt     1920

cagagacttc tcccagttct ctgtcaagcc cacgggctga ctcccgatca agttgtagcg     1980

attgcgtcgc atgacggagg gaaacaagca ttggagactg tccaacggct ccttcccgtg     2040

ttgtgtcaag cccacggttt gacgcctgca caagtggtcg ccatcgcctc gaatggcggc     2100

ggtaagcagg cgctggaaac agtacagcgc ctgctgcctg tactgtgcca ggatcatgga     2160

ctgaccccag accaggtagt cgcaatcgcg tcgaacattg ggggaaagca agccctggaa     2220

accgtgcaaa ggttgttgcc ggtcctttgt caagaccacg gccttacacc ggagcaagtc     2280

gtggccattg caaataataa cggtggcaaa caggctcttg agacggttca gagacttctc     2340

ccagttctct gtcaagccca cgggctgact cccgatcaag ttgtagcgat tgcgtccaac     2400

ggtggaggga aacaagcatt ggagactgtc caacggctcc ttcccgtgtt gtgtcaagcc     2460

cacggtttga cgcctgcaca agtggtcgcc atcgcctcga atggcggcgg taagcaggcg     2520

ctggaaacag tacagcgcct gctgcctgta ctgtgccagg atcatggact gacacccgaa     2580

caggtggtcg ccattgcttc taacatcgga ggacggccag ccttggagtc catcgtagcc     2640

caattgtcca ggcccgatcc cgcgttggct gcgttaacga atgaccatct ggtggcgttg     2700

gcatgtcttg gtggacgacc cgcgctcgat gcagtcaaaa agggtctgcc tcatgctccc     2760

gcattgatca aaagaaccaa ccggcggatt cccgagagaa cttcccatcg agtcgcggga     2820

tcccaactag tcaaaagtga actggaggag aagaaatctg aacttcgtca taaattgaaa     2880

tatgtgcctc atgaatatat tgaattaatt gaaattgcca gaaatcccac tcaggataga     2940

attcttgaaa tgaaggtaat ggaatttttt atgaaagttt atggatatag aggtgagcat     3000

ttgggtggat caaggaaacc ggacggagca atttatactg tcggatctcc tattgattac     3060

ggtgtgatcg tggatactaa agcttatagc ggaggttata atctgccaat tggccaagca     3120

gatgaaatgc aacgatatgt caaggaaaat caaacacgaa acaaacatat caaccctaat     3180

gaatggtgga aagtctatcc atcttctgta acggaattta agtttttatt tgtgagtggt     3240

cactttaaag gaaactacaa agctcagctt acacgattaa atcggaagac taattgtaat     3300

ggagctgttc ttagtgtaga agagctttta attggtggag aaatgattaa agccggcaca     3360

ttaaccttag aggaagtcag acggaaattt aataacggcg agataaactt ttaa           3414


<210>  28
<211>  8466
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  JDS70 (with 3'TALEN.KKR.Sharkey)

<400>  28
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gctggctagc      900

accatggact acaaagacca tgacggtgat tataaagatc atgacatcga ttacaaggat      960

gacgatgaca agatggcccc caagaagaag aggaaggtgg gcattcaccg cggggtacct     1020

atggtggact tgaggacact cggttattcg caacagcaac aggagaaaat caagcctaag     1080

gtcaggagca ccgtcgcgca acaccacgag gcgcttgtgg ggcatggctt cactcatgcg     1140

catattgtcg cgctttcaca gcaccctgcg gcgcttggga cggtggctgt caaataccaa     1200

gatatgattg cggccctgcc cgaagccacg cacgaggcaa ttgtaggggt cggtaaacag     1260

tggtcgggag cgcgagcact tgaggcgctg ctgactgtgg cgggtgagct tagggggcct     1320

ccgctccagc tcgacaccgg gcagctgctg aagatcgcga agagaggggg agtaacagcg     1380

gtagaggcag tgcacgcctg gcgcaatgcg ctcaccgggg cccccttgaa cctgacccca     1440

gaccaggtag tcgcaatcgc gtcgaacatt gggggaaagc aagccctgga aaccgtgcaa     1500

aggttgttgc cggtcctttg tcaagaccac ggccttacac cggagcaagt cgtggccatt     1560

gcaagcaaca tcggtggcaa acaggctctt gagacggttc agagacttct cccagttctc     1620

tgtcaagccc acgggctgac tcccgatcaa gttgtagcga ttgcgaataa caatggaggg     1680

aaacaagcat tggagactgt ccaacggctc cttcccgtgt tgtgtcaagc ccacggtttg     1740

acgcctgcac aagtggtcgc catcgccagc catgatggcg gtaagcaggc gctggaaaca     1800

gtacagcgcc tgctgcctgt actgtgccag gatcatggac tgaccccaga ccaggtagtc     1860

gcaatcgcgt cgaacattgg gggaaagcaa gccctggaaa ccgtgcaaag gttgttgccg     1920

gtcctttgtc aagaccacgg ccttacaccg gagcaagtcg tggccattgc aaataataac     1980

ggtggcaaac aggctcttga gacggttcag agacttctcc cagttctctg tcaagcccac     2040

gggctgactc ccgatcaagt tgtagcgatt gcgtccaacg gtggagggaa acaagcattg     2100

gagactgtcc aacggctcct tcccgtgttg tgtcaagccc acggtttgac gcctgcacaa     2160

gtggtcgcca tcgccaacaa caacggcggt aagcaggcgc tggaaacagt acagcgcctg     2220

ctgcctgtac tgtgccagga tcatggactg accccagacc aggtagtcgc aatcgcgaac     2280

aataatgggg gaaagcaagc cctggaaacc gtgcaaaggt tgttgccggt cctttgtcaa     2340

gaccacggcc ttacaccgga gcaagtcgtg gccattgcaa ataataacgg tggcaaacag     2400

gctcttgaga cggttcagag acttctccca gttctctgtc aagcccacgg gctgactccc     2460

gatcaagttg tagcgattgc gtccaacggt ggagggaaac aagcattgga gactgtccaa     2520

cggctccttc ccgtgttgtg tcaagcccac ggtttgacgc ctgcacaagt ggtcgccatc     2580

gcctcgaatg gcggcggtaa gcaggcgctg gaaacagtac agcgcctgct gcctgtactg     2640

tgccaggatc atggactgac cccagaccag gtagtcgcaa tcgcgtcaca tgacggggga     2700

aagcaagccc tggaaaccgt gcaaaggttg ttgccggtcc tttgtcaaga ccacggcctt     2760

acaccggagc aagtcgtggc cattgcatcc cacgacggtg gcaaacaggc tcttgagacg     2820

gttcagagac ttctcccagt tctctgtcaa gcccacgggc tgactcccga tcaagttgta     2880

gcgattgcgt cgcatgacgg agggaaacaa gcattggaga ctgtccaacg gctccttccc     2940

gtgttgtgtc aagcccacgg tttgacgcct gcacaagtgg tcgccatcgc ctcgaatggc     3000

ggcggtaagc aggcgctgga aacagtacag cgcctgctgc ctgtactgtg ccaggatcat     3060

ggactgaccc cagaccaggt agtcgcaatc gcgtcgaaca ttgggggaaa gcaagccctg     3120

gaaaccgtgc aaaggttgtt gccggtcctt tgtcaagacc acggccttac accggagcaa     3180

gtcgtggcca ttgcaaataa taacggtggc aaacaggctc ttgagacggt tcagagactt     3240

ctcccagttc tctgtcaagc ccacgggctg actcccgatc aagttgtagc gattgcgtcc     3300

aacggtggag ggaaacaagc attggagact gtccaacggc tccttcccgt gttgtgtcaa     3360

gcccacggtt tgacgcctgc acaagtggtc gccatcgcct cgaatggcgg cggtaagcag     3420

gcgctggaaa cagtacagcg cctgctgcct gtactgtgcc aggatcatgg actgacaccc     3480

gaacaggtgg tcgccattgc ttctaacatc ggaggacggc cagccttgga gtccatcgta     3540

gcccaattgt ccaggcccga tcccgcgttg gctgcgttaa cgaatgacca tctggtggcg     3600

ttggcatgtc ttggtggacg acccgcgctc gatgcagtca aaaagggtct gcctcatgct     3660

cccgcattga tcaaaagaac caaccggcgg attcccgaga gaacttccca tcgagtcgcg     3720

ggatcccaac tagtcaaaag tgaactggag gagaagaaat ctgaacttcg tcataaattg     3780

aaatatgtgc ctcatgaata tattgaatta attgaaattg ccagaaatcc cactcaggat     3840

agaattcttg aaatgaaggt aatggaattt tttatgaaag tttatggata tagaggtgag     3900

catttgggtg gatcaaggaa accggacgga gcaatttata ctgtcggatc tcctattgat     3960

tacggtgtga tcgtggatac taaagcttat agcggaggtt ataatctgcc aattggccaa     4020

gcagatgaaa tgcaacgata tgtcaaggaa aatcaaacac gaaacaaaca tatcaaccct     4080

aatgaatggt ggaaagtcta tccatcttct gtaacggaat ttaagttttt atttgtgagt     4140

ggtcacttta aaggaaacta caaagctcag cttacacgat taaatcggaa gactaattgt     4200

aatggagctg ttcttagtgt agaagagctt ttaattggtg gagaaatgat taaagccggc     4260

acattaacct tagaggaagt cagacggaaa tttaataacg gcgagataaa cttttaaggg     4320

cccttcgaag gtaagcctat ccctaaccct ctcctcggtc tcgattctac gcgtaccggt     4380

catcatcacc atcaccattg agtttaaacc cgctgatcag cctcgactgt gccttctagt     4440

tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact     4500

cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat     4560

tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc     4620

aggcatgctg gggatgcggt gggctctatg gcttctgagg cggaaagaac cagctggggc     4680

tctagggggt atccccacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt     4740

acgcgcagcg tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc     4800

ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg gggcatccct     4860

ttagggttcc gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat     4920

ggttcacgta gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc     4980

acgttcttta atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc     5040

tattcttttg atttataagg gattttgggg atttcggcct attggttaaa aaatgagctg     5100

atttaacaaa aatttaacgc gaattaattc tgtggaatgt gtgtcagtta gggtgtggaa     5160

agtccccagg ctccccaggc aggcagaagt atgcaaagca tgcatctcaa ttagtcagca     5220

accaggtgtg gaaagtcccc aggctcccca gcaggcagaa gtatgcaaag catgcatctc     5280

aattagtcag caaccatagt cccgccccta actccgccca tcccgcccct aactccgccc     5340

agttccgccc attctccgcc ccatggctga ctaatttttt ttatttatgc agaggccgag     5400

gccgcctctg cctctgagct attccagaag tagtgaggag gcttttttgg aggcctaggc     5460

ttttgcaaaa agctcccggg agcttgtata tccattttcg gatctgatca gcacgtgttg     5520

acaattaatc atcggcatag tatatcggca tagtataata cgacaaggtg aggaactaaa     5580

ccatggccaa gcctttgtct caagaagaat ccaccctcat tgaaagagca acggctacaa     5640

tcaacagcat ccccatctct gaagactaca gcgtcgccag cgcagctctc tctagcgacg     5700

gccgcatctt cactggtgtc aatgtatatc attttactgg gggaccttgt gcagaactcg     5760

tggtgctggg cactgctgct gctgcggcag ctggcaacct gacttgtatc gtcgcgatcg     5820

gaaatgagaa caggggcatc ttgagcccct gcggacggtg tcgacaggtg cttctcgatc     5880

tgcatcctgg gatcaaagcg atagtgaagg acagtgatgg acagccgacg gcagttggga     5940

ttcgtgaatt gctgccctct ggttatgtgt gggagggcta agcacttcgt ggccgaggag     6000

caggactgac acgtgctacg agatttcgat tccaccgccg ccttctatga aaggttgggc     6060

ttcggaatcg ttttccggga cgccggctgg atgatcctcc agcgcgggga tctcatgctg     6120

gagttcttcg cccaccccaa cttgtttatt gcagcttata atggttacaa ataaagcaat     6180

agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc     6240

aaactcatca atgtatctta tcatgtctgt ataccgtcga cctctagcta gagcttggcg     6300

taatcatggt catagctgtt tcctgtgtga aattgttatc cgctcacaat tccacacaac     6360

atacgagccg gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag ctaactcaca     6420

ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg ccagctgcat     6480

taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc ttccgcttcc     6540

tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc agctcactca     6600

aaggcggtaa tacggttatc cacagaatca ggggataacg caggaaagaa catgtgagca     6660

aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg     6720

ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg     6780

acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt     6840

ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt     6900

tctcaatgct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc     6960

tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt     7020

gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt     7080

agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc     7140

tacactagaa ggacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa     7200

agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt     7260

tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct     7320

acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta     7380

tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa     7440

agtatatatg agtaaacttg gtctgacagt taccaatgct taatcagtga ggcacctatc     7500

tcagcgatct gtctatttcg ttcatccata gttgcctgac tccccgtcgt gtagataact     7560

acgatacggg agggcttacc atctggcccc agtgctgcaa tgataccgcg agacccacgc     7620

tcaccggctc cagatttatc agcaataaac cagccagccg gaagggccga gcgcagaagt     7680

ggtcctgcaa ctttatccgc ctccatccag tctattaatt gttgccggga agctagagta     7740

agtagttcgc cagttaatag tttgcgcaac gttgttgcca ttgctacagg catcgtggtg     7800

tcacgctcgt cgtttggtat ggcttcattc agctccggtt cccaacgatc aaggcgagtt     7860

acatgatccc ccatgttgtg caaaaaagcg gttagctcct tcggtcctcc gatcgttgtc     7920

agaagtaagt tggccgcagt gttatcactc atggttatgg cagcactgca taattctctt     7980

actgtcatgc catccgtaag atgcttttct gtgactggtg agtactcaac caagtcattc     8040

tgagaatagt gtatgcggcg accgagttgc tcttgcccgg cgtcaatacg ggataatacc     8100

gcgccacata gcagaacttt aaaagtgctc atcattggaa aacgttcttc ggggcgaaaa     8160

ctctcaagga tcttaccgct gttgagatcc agttcgatgt aacccactcg tgcacccaac     8220

tgatcttcag catcttttac tttcaccagc gtttctgggt gagcaaaaac aggaaggcaa     8280

aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt gaatactcat actcttcctt     8340

tttcaatatt attgaagcat ttatcagggt tattgtctca tgagcggata catatttgaa     8400

tgtatttaga aaaataaaca aataggggtt ccgcgcacat ttccccgaaa agtgccacct     8460

gacgtc                                                                8466


<210>  29
<211>  8261
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  JDS78 (with 5'TALEN)

<400>  29
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gctggctagc      900

accatggact acaaagacca tgacggtgat tataaagatc atgacatcga ttacaaggat      960

gacgatgaca agatggcccc caagaagaag aggaaggtgg gcattcaccg cggggtacct     1020

atggtggact tgaggacact cggttattcg caacagcaac aggagaaaat caagcctaag     1080

gtcaggagca ccgtcgcgca acaccacgag gcgcttgtgg ggcatggctt cactcatgcg     1140

catattgtcg cgctttcaca gcaccctgcg gcgcttggga cggtggctgt caaataccaa     1200

gatatgattg cggccctgcc cgaagccacg cacgaggcaa ttgtaggggt cggtaaacag     1260

tggtcgggag cgcgagcact tgaggcgctg ctgactgtgg cgggtgagct tagggggcct     1320

ccgctccagc tcgacaccgg gcagctgctg aagatcgcga agagaggggg agtaacagcg     1380

gtagaggcag tgcacgcctg gcgcaatgcg ctcaccgggg cccccttgaa cctgacccca     1440

gaccaggtag tcgcaatcgc gtcacatgac gggggaaagc aagccctgga aaccgtgcaa     1500

aggttgttgc cggtcctttg tcaagaccac ggccttacac cggagcaagt cgtggccatt     1560

gcaagcaatg ggggtggcaa acaggctctt gagacggttc agagacttct cccagttctc     1620

tgtcaagccc acgggctgac tcccgatcaa gttgtagcga ttgcgtcgca tgacggaggg     1680

aaacaagcat tggagactgt ccaacggctc cttcccgtgt tgtgtcaagc ccacggtttg     1740

acgcctgcac aagtggtcgc catcgcctcg aatggcggcg gtaagcaggc gctggaaaca     1800

gtacagcgcc tgctgcctgt actgtgccag gatcatggac tgaccccaga ccaggtagtc     1860

gcaatcgcga acaataatgg gggaaagcaa gccctggaaa ccgtgcaaag gttgttgccg     1920

gtcctttgtc aagaccacgg ccttacaccg gagcaagtcg tggccattgc aaataataac     1980

ggtggcaaac aggctcttga gacggttcag agacttctcc cagttctctg tcaagcccac     2040

gggctgactc ccgatcaagt tgtagcgatt gcgtccaacg gtggagggaa acaagcattg     2100

gagactgtcc aacggctcct tcccgtgttg tgtcaagccc acggtttgac gcctgcacaa     2160

gtggtcgcca tcgcctcgaa tggcggcggt aagcaggcgc tggaaacagt acagcgcctg     2220

ctgcctgtac tgtgccagga tcatggactg actcccgatc aagttgtagc gattgcgtcg     2280

aacattggag ggaaacaagc attggagact gtccaacggc tccttcccgt gttgtgtcaa     2340

gcccacggtc ttacaccgga gcaagtcgtg gccattgcaa ataataacgg tggcaaacag     2400

gctcttgaga cggttcagag acttctccca gttctctgtc aagcccacgg gctgactccc     2460

gatcaagttg tagcgattgc gtcgaacatt ggagggaaac aagcattgga gactgtccaa     2520

cggctccttc ccgtgttgtg tcaagcccac ggtttgacgc ctgcacaagt ggtcgccatc     2580

gccagccatg atggcggtaa gcaggcgctg gaaacagtac agcgcctgct gcctgtactg     2640

tgccaggatc atggactgac cccagaccag gtagtcgcaa tcgcgtcaca tgacggggga     2700

aagcaagccc tggaaaccgt gcaaaggttg ttgccggtcc tttgtcaaga ccacggcctt     2760

acaccggagc aagtcgtggc cattgcaagc aacatcggtg gcaaacaggc tcttgagacg     2820

gttcagagac ttctcccagt tctctgtcaa gcccacgggc tgactcccga tcaagttgta     2880

gcgattgcga ataacaatgg agggaaacaa gcattggaga ctgtccaacg gctccttccc     2940

gtgttgtgtc aagcccacgg tttgacgcct gcacaagtgg tcgccatcgc ctccaatatt     3000

ggcggtaagc aggcgctgga aacagtacag cgcctgctgc ctgtactgtg ccaggatcat     3060

ggactgaccc cagaccaggt agtcgcaatc gcgtcaaacg gagggggaaa gcaagccctg     3120

gaaaccgtgc aaaggttgtt gccggtcctt tgtcaagacc acggccttac accggagcaa     3180

gtcgtggcca ttgcatccca cgacggtggc aaacaggctc ttgagacggt tcagagactt     3240

ctcccagttc tctgtcaagc ccacgggctg acacccgaac aggtggtcgc cattgcttct     3300

aatgggggag gacggccagc cttggagtcc atcgtagccc aattgtccag gcccgatccc     3360

gcgttggctg cgttaacgaa tgaccatctg gtggcgttgg catgtcttgg tggacgaccc     3420

gcgctcgatg cagtcaaaaa gggtctgcct catgctcccg cattgatcaa aagaaccaac     3480

cggcggattc ccgagagaac ttcccatcga gtcgcgggat cccaactagt caaaagtgaa     3540

ctggaggaga agaaatctga acttcgtcat aaattgaaat atgtgcctca tgaatatatt     3600

gaattaattg aaattgccag aaattccact caggatagaa ttcttgaaat gaaggtaatg     3660

gaatttttta tgaaagttta tggatataga ggtaaacatt tgggtggatc aaggaaaccg     3720

gacggagcaa tttatactgt cggatctcct attgattacg gtgtgatcgt ggatactaaa     3780

gcttatagcg gaggttataa tctgccaatt ggccaagcag atgaaatgca acgatatgtc     3840

gaagaaaatc aaacacgaaa caaacatatc aaccctaatg aatggtggaa agtctatcca     3900

tcttctgtaa cggaatttaa gtttttattt gtgagtggtc actttaaagg aaactacaaa     3960

gctcagctta cacgattaaa tcatatcact aattgtaatg gagctgttct tagtgtagaa     4020

gagcttttaa ttggtggaga aatgattaaa gccggcacat taaccttaga ggaagtcaga     4080

cggaaattta ataacggcga gataaacttt taagggccct tcgaaggtaa gcctatccct     4140

aaccctctcc tcggtctcga ttctacgcgt accggtcatc atcaccatca ccattgagtt     4200

taaacccgct gatcagcctc gactgtgcct tctagttgcc agccatctgt tgtttgcccc     4260

tcccccgtgc cttccttgac cctggaaggt gccactccca ctgtcctttc ctaataaaat     4320

gaggaaattg catcgcattg tctgagtagg tgtcattcta ttctgggggg tggggtgggg     4380

caggacagca agggggagga ttgggaagac aatagcaggc atgctgggga tgcggtgggc     4440

tctatggctt ctgaggcgga aagaaccagc tggggctcta gggggtatcc ccacgcgccc     4500

tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc gcagcgtgac cgctacactt     4560

gccagcgccc tagcgcccgc tcctttcgct ttcttccctt cctttctcgc cacgttcgcc     4620

ggctttcccc gtcaagctct aaatcggggc atccctttag ggttccgatt agtgctttac     4680

ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg ccatcgccct     4740

gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt ggactcttgt     4800

tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta taagggattt     4860

tggggatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt aacgcgaatt     4920

aattctgtgg aatgtgtgtc agttagggtg tggaaagtcc ccaggctccc caggcaggca     4980

gaagtatgca aagcatgcat ctcaattagt cagcaaccag gtgtggaaag tccccaggct     5040

ccccagcagg cagaagtatg caaagcatgc atctcaatta gtcagcaacc atagtcccgc     5100

ccctaactcc gcccatcccg cccctaactc cgcccagttc cgcccattct ccgccccatg     5160

gctgactaat tttttttatt tatgcagagg ccgaggccgc ctctgcctct gagctattcc     5220

agaagtagtg aggaggcttt tttggaggcc taggcttttg caaaaagctc ccgggagctt     5280

gtatatccat tttcggatct gatcagcacg tgttgacaat taatcatcgg catagtatat     5340

cggcatagta taatacgaca aggtgaggaa ctaaaccatg gccaagcctt tgtctcaaga     5400

agaatccacc ctcattgaaa gagcaacggc tacaatcaac agcatcccca tctctgaaga     5460

ctacagcgtc gccagcgcag ctctctctag cgacggccgc atcttcactg gtgtcaatgt     5520

atatcatttt actgggggac cttgtgcaga actcgtggtg ctgggcactg ctgctgctgc     5580

ggcagctggc aacctgactt gtatcgtcgc gatcggaaat gagaacaggg gcatcttgag     5640

cccctgcgga cggtgtcgac aggtgcttct cgatctgcat cctgggatca aagcgatagt     5700

gaaggacagt gatggacagc cgacggcagt tgggattcgt gaattgctgc cctctggtta     5760

tgtgtgggag ggctaagcac ttcgtggccg aggagcagga ctgacacgtg ctacgagatt     5820

tcgattccac cgccgccttc tatgaaaggt tgggcttcgg aatcgttttc cgggacgccg     5880

gctggatgat cctccagcgc ggggatctca tgctggagtt cttcgcccac cccaacttgt     5940

ttattgcagc ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag     6000

catttttttc actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg     6060

tctgtatacc gtcgacctct agctagagct tggcgtaatc atggtcatag ctgtttcctg     6120

tgtgaaattg ttatccgctc acaattccac acaacatacg agccggaagc ataaagtgta     6180

aagcctgggg tgcctaatga gtgagctaac tcacattaat tgcgttgcgc tcactgcccg     6240

ctttccagtc gggaaacctg tcgtgccagc tgcattaatg aatcggccaa cgcgcgggga     6300

gaggcggttt gcgtattggg cgctcttccg cttcctcgct cactgactcg ctgcgctcgg     6360

tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag     6420

aatcagggga taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc     6480

gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca     6540

aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt     6600

ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc     6660

tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca atgctcacgc tgtaggtatc     6720

tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc     6780

ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact     6840

tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg     6900

ctacagagtt cttgaagtgg tggcctaact acggctacac tagaaggaca gtatttggta     6960

tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca     7020

aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa     7080

aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct cagtggaacg     7140

aaaactcacg ttaagggatt ttggtcatga gattatcaaa aaggatcttc acctagatcc     7200

ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa acttggtctg     7260

acagttacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta tttcgttcat     7320

ccatagttgc ctgactcccc gtcgtgtaga taactacgat acgggagggc ttaccatctg     7380

gccccagtgc tgcaatgata ccgcgagacc cacgctcacc ggctccagat ttatcagcaa     7440

taaaccagcc agccggaagg gccgagcgca gaagtggtcc tgcaacttta tccgcctcca     7500

tccagtctat taattgttgc cgggaagcta gagtaagtag ttcgccagtt aatagtttgc     7560

gcaacgttgt tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt     7620

cattcagctc cggttcccaa cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa     7680

aagcggttag ctccttcggt cctccgatcg ttgtcagaag taagttggcc gcagtgttat     7740

cactcatggt tatggcagca ctgcataatt ctcttactgt catgccatcc gtaagatgct     7800

tttctgtgac tggtgagtac tcaaccaagt cattctgaga atagtgtatg cggcgaccga     7860

gttgctcttg cccggcgtca atacgggata ataccgcgcc acatagcaga actttaaaag     7920

tgctcatcat tggaaaacgt tcttcggggc gaaaactctc aaggatctta ccgctgttga     7980

gatccagttc gatgtaaccc actcgtgcac ccaactgatc ttcagcatct tttactttca     8040

ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg     8100

cgacacggaa atgttgaata ctcatactct tcctttttca atattattga agcatttatc     8160

agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat aaacaaatag     8220

gggttccgcg cacatttccc cgaaaagtgc cacctgacgt c                         8261


<210>  30
<211>  3210
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5'TALEN (in JDS78) Constructs T256/T258

<400>  30
atggactaca aagaccatga cggtgattat aaagatcatg acatcgatta caaggatgac       60

gatgacaaga tggcccccaa gaagaagagg aaggtgggca ttcaccgcgg ggtacctatg      120

gtggacttga ggacactcgg ttattcgcaa cagcaacagg agaaaatcaa gcctaaggtc      180

aggagcaccg tcgcgcaaca ccacgaggcg cttgtggggc atggcttcac tcatgcgcat      240

attgtcgcgc tttcacagca ccctgcggcg cttgggacgg tggctgtcaa ataccaagat      300

atgattgcgg ccctgcccga agccacgcac gaggcaattg taggggtcgg taaacagtgg      360

tcgggagcgc gagcacttga ggcgctgctg actgtggcgg gtgagcttag ggggcctccg      420

ctccagctcg acaccgggca gctgctgaag atcgcgaaga gagggggagt aacagcggta      480

gaggcagtgc acgcctggcg caatgcgctc accggggccc ccttgaacct gaccccagac      540

caggtagtcg caatcgcgtc acatgacggg ggaaagcaag ccctggaaac cgtgcaaagg      600

ttgttgccgg tcctttgtca agaccacggc cttacaccgg agcaagtcgt ggccattgca      660

agcaatgggg gtggcaaaca ggctcttgag acggttcaga gacttctccc agttctctgt      720

caagcccacg ggctgactcc cgatcaagtt gtagcgattg cgtcgcatga cggagggaaa      780

caagcattgg agactgtcca acggctcctt cccgtgttgt gtcaagccca cggtttgacg      840

cctgcacaag tggtcgccat cgcctcgaat ggcggcggta agcaggcgct ggaaacagta      900

cagcgcctgc tgcctgtact gtgccaggat catggactga ccccagacca ggtagtcgca      960

atcgcgaaca ataatggggg aaagcaagcc ctggaaaccg tgcaaaggtt gttgccggtc     1020

ctttgtcaag accacggcct tacaccggag caagtcgtgg ccattgcaaa taataacggt     1080

ggcaaacagg ctcttgagac ggttcagaga cttctcccag ttctctgtca agcccacggg     1140

ctgactcccg atcaagttgt agcgattgcg tccaacggtg gagggaaaca agcattggag     1200

actgtccaac ggctccttcc cgtgttgtgt caagcccacg gtttgacgcc tgcacaagtg     1260

gtcgccatcg cctcgaatgg cggcggtaag caggcgctgg aaacagtaca gcgcctgctg     1320

cctgtactgt gccaggatca tggactgact cccgatcaag ttgtagcgat tgcgtcgaac     1380

attggaggga aacaagcatt ggagactgtc caacggctcc ttcccgtgtt gtgtcaagcc     1440

cacggtctta caccggagca agtcgtggcc attgcaaata ataacggtgg caaacaggct     1500

cttgagacgg ttcagagact tctcccagtt ctctgtcaag cccacgggct gactcccgat     1560

caagttgtag cgattgcgtc gaacattgga gggaaacaag cattggagac tgtccaacgg     1620

ctccttcccg tgttgtgtca agcccacggt ttgacgcctg cacaagtggt cgccatcgcc     1680

agccatgatg gcggtaagca ggcgctggaa acagtacagc gcctgctgcc tgtactgtgc     1740

caggatcatg gactgacccc agaccaggta gtcgcaatcg cgtcacatga cgggggaaag     1800

caagccctgg aaaccgtgca aaggttgttg ccggtccttt gtcaagacca cggccttaca     1860

ccggagcaag tcgtggccat tgcaagcaac atcggtggca aacaggctct tgagacggtt     1920

cagagacttc tcccagttct ctgtcaagcc cacgggctga ctcccgatca agttgtagcg     1980

attgcgaata acaatggagg gaaacaagca ttggagactg tccaacggct ccttcccgtg     2040

ttgtgtcaag cccacggttt gacgcctgca caagtggtcg ccatcgcctc caatattggc     2100

ggtaagcagg cgctggaaac agtacagcgc ctgctgcctg tactgtgcca ggatcatgga     2160

ctgaccccag accaggtagt cgcaatcgcg tcaaacggag ggggaaagca agccctggaa     2220

accgtgcaaa ggttgttgcc ggtcctttgt caagaccacg gccttacacc ggagcaagtc     2280

gtggccattg catcccacga cggtggcaaa caggctcttg agacggttca gagacttctc     2340

ccagttctct gtcaagccca cgggctgaca cccgaacagg tggtcgccat tgcttctaat     2400

gggggaggac ggccagcctt ggagtccatc gtagcccaat tgtccaggcc cgatcccgcg     2460

ttggctgcgt taacgaatga ccatctggtg gcgttggcat gtcttggtgg acgacccgcg     2520

ctcgatgcag tcaaaaaggg tctgcctcat gctcccgcat tgatcaaaag aaccaaccgg     2580

cggattcccg agagaacttc ccatcgagtc gcgggatccc aactagtcaa aagtgaactg     2640

gaggagaaga aatctgaact tcgtcataaa ttgaaatatg tgcctcatga atatattgaa     2700

ttaattgaaa ttgccagaaa ttccactcag gatagaattc ttgaaatgaa ggtaatggaa     2760

ttttttatga aagtttatgg atatagaggt aaacatttgg gtggatcaag gaaaccggac     2820

ggagcaattt atactgtcgg atctcctatt gattacggtg tgatcgtgga tactaaagct     2880

tatagcggag gttataatct gccaattggc caagcagatg aaatgcaacg atatgtcgaa     2940

gaaaatcaaa cacgaaacaa acatatcaac cctaatgaat ggtggaaagt ctatccatct     3000

tctgtaacgg aatttaagtt tttatttgtg agtggtcact ttaaaggaaa ctacaaagct     3060

cagcttacac gattaaatca tatcactaat tgtaatggag ctgttcttag tgtagaagag     3120

cttttaattg gtggagaaat gattaaagcc ggcacattaa ccttagagga agtcagacgg     3180

aaatttaata acggcgagat aaacttttaa                                      3210


<210>  31
<211>  1840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TALE component of mutant clone; does not include FokI; T259 
       mutant

<400>  31
gaacctgacc ccagaccagg tagtcgcaat cgcgtcacat gacgggggaa agcaagccct       60

ggaaaccgtg caaaggttgt tgccggtcct ttgtcaagac cacggcctta caccggagca      120

agtcgtggcc attgcaagca atgggggtgg caaacaggct cttgagacgg ttcagagact      180

tctcccagtt ctctgtcaag cccacgggct gactcccgat caagttgtag cgattgcgtc      240

gcatgacgga gggaaacaag cattggagac tgtccaacgg ctccttcccg tgttgtgtca      300

agcccacggt ttgacgcctg cacaagtggt cgccatcgcc tcgaatggcg gcggtaagca      360

ggcgctggaa acagtacagc gcctgctgcc tgtactgtgc caggatcatg gactgacccc      420

agaccaggta gtcgcaatcg cgaacaattc ggggggaaag caagccctgg aaaccgtgca      480

aaggttgttg ccggtccttt gtcaagacca cggccttaca ccggagcaag tcgtggccat      540

tgcaaataat aacggtggca aacaggctct tgagacggtt cagagacttc tcccagttct      600

ctgtcaagcc cacgggctga ctcccgatca agttgtagcg attgcgtcca acggtggagg      660

gaaacaagca ttggagactg tccaacggct ccttcccgtg ttgtgtcaag cccacggttt      720

gacgcctgca caagtggtcg ccatcgcctc gaattcgggc ggtaagcagg cgctggaaac      780

agtacagcgc ctgctgcctg tactgtgcca ggatcatgga ctgaccccag accaggtagt      840

cgcaatcgcg tcgaacattg ggggaaagca agccctggaa accgtgcaaa ggttgttgcc      900

ggtcctttgt caagaccacg gccttacacc ggagcaagtc gtggccattg caaataataa      960

cggtggcaaa caggctcttg agacggttca gagacttctc ccagttctct gtcaagccca     1020

cgggctgact cccgatcaag ttgtagcgat tgcgtcgaac attggaggga aacaagcatt     1080

ggagactgtc caacggctcc ttcccgtgtt gtgtcaagcc cacggtttga cgcctgcaca     1140

agtggtcgcc atcgccagcc atgatggcgg taagcaggcg ctggaaacag tacagcgcct     1200

gctgcctgta ctgtgccagg atcatggact gaccccagac caggtagtcg caatcgcgtc     1260

acatgacggg ggaaagcaag ccctggaaac cgtgcaaagg ttgttgccgg tcctttgtca     1320

agaccacggc cttacaccgg agcaagtcgt ggccattgca agcaacatcg gtggcaaaca     1380

ggctcttgag acggttcaga gacttctccc agttctctgt caagcccacg ggctgactcc     1440

cgatcaagtt gtagcgattg cgaataacaa tggagggaaa caagcattgg agactgtcca     1500

acggctcctt cccgtgttgt gtcaagccca cggtttgacg cctgcacaag tggtcgccat     1560

cgcctccaat attggcggta agcaggcgct ggaaacagta cagcgcctgc tgcctgtact     1620

gtgccaggat catggactga ccccagacca ggtagtcgca atcgcgtcaa acggaggggg     1680

aaagcaagcc ctggaaaccg tgcaaaggtt gttgccggtc ctttgtcaag accacggcct     1740

tacaccggag caagtcgtgg ccattgcatc caattcgggt ggcaaacagg ctcttgagac     1800

ggttcagaga cttctcccag ttctctgtca agcccacggg                           1840


