                         SEQUENCE LISTING

<110>  Grifols Worldwide Operations Limited
       Ortho-Clinical Diagnostics, Inc.
       Ortho Clinical Diagnostics, K.K.
 
<120>  HCV NS4A/Modified NS3 Polypeptides and Uses Thereof

<130>  CDS5174WOPCT

<150>  US 62/139,183
<151>  2015-03-27

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  1860
<212>  PRT
<213>  Hepatitis C virus

<400>  1

Met Ser Thr Asn Pro Lys Pro Gln Lys Lys Asn Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Thr Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Ala Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Met Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Ala Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Gly Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Met Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr His Val Thr Gly Gly Ser Ala Gly His Thr Val Ser Gly Phe Val 
385                 390                 395                 400 


Ser Leu Leu Ala Pro Gly Ala Lys Gln Asn Val Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Leu Asn Ser Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Trp Leu Ala Gly Leu Phe Tyr His His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg Pro Leu Thr Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Pro 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Glu Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Ala Gly Asn 
                565                 570                 575     


Asn Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Asp Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr 
    610                 615                 620                 


Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Thr Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Ala Ser Trp Ala Ile Lys Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala Ala Leu Glu Asn Leu Val 
            740                 745                 750         


Ile Leu Asn Ala Ala Ser Leu Ala Gly Thr His Gly Leu Val Ser Phe 
        755                 760                 765             


Leu Val Phe Phe Cys Phe Ala Trp Tyr Leu Lys Gly Lys Trp Val Pro 
    770                 775                 780                 


Gly Ala Val Tyr Thr Phe Tyr Gly Met Trp Pro Leu Leu Leu Leu Leu 
785                 790                 795                 800 


Leu Ala Leu Pro Gln Arg Ala Tyr Ala Leu Asp Thr Glu Val Ala Ala 
                805                 810                 815     


Ser Cys Gly Gly Val Val Leu Val Gly Leu Met Ala Leu Thr Leu Ser 
            820                 825                 830         


Pro Tyr Tyr Lys Arg Tyr Ile Ser Trp Cys Leu Trp Trp Leu Gln Tyr 
        835                 840                 845             


Phe Leu Thr Arg Val Glu Ala Gln Leu His Val Trp Ile Pro Pro Leu 
    850                 855                 860                 


Asn Val Arg Gly Gly Arg Asp Ala Val Ile Leu Leu Met Cys Ala Val 
865                 870                 875                 880 


His Pro Thr Leu Val Phe Asp Ile Thr Lys Leu Leu Leu Ala Val Phe 
                885                 890                 895     


Gly Pro Leu Trp Ile Leu Gln Ala Ser Leu Leu Lys Val Pro Tyr Phe 
            900                 905                 910         


Val Arg Val Gln Gly Leu Leu Arg Phe Cys Ala Leu Ala Arg Lys Met 
        915                 920                 925             


Ile Gly Gly His Tyr Val Gln Met Val Ile Ile Lys Leu Gly Ala Leu 
    930                 935                 940                 


Thr Gly Thr Tyr Val Tyr Asn His Leu Thr Pro Leu Arg Asp Trp Ala 
945                 950                 955                 960 


His Asn Gly Leu Arg Asp Leu Ala Val Ala Val Glu Pro Val Val Phe 
                965                 970                 975     


Ser Gln Met Glu Thr Lys Leu Ile Thr Trp Gly Ala Asp Thr Ala Ala 
            980                 985                 990         


Cys Gly Asp Ile Ile Asn Gly Leu  Pro Val Ser Ala Arg  Arg Gly Arg 
        995                 1000                 1005             


Glu Ile  Leu Leu Gly Pro Ala  Asp Gly Met Val Ser  Lys Gly Trp 
    1010                 1015                 1020             


Arg Leu  Leu Ala Pro Ile Thr  Ala Tyr Ala Gln Gln  Thr Arg Gly 
    1025                 1030                 1035             


Leu Leu  Gly Cys Ile Ile Thr  Ser Leu Thr Gly Arg  Asp Lys Asn 
    1040                 1045                 1050             


Gln Val  Glu Gly Glu Val Gln  Ile Val Ser Thr Ala  Ala Gln Thr 
    1055                 1060                 1065             


Phe Leu  Ala Thr Cys Ile Asn  Gly Val Cys Trp Thr  Val Tyr His 
    1070                 1075                 1080             


Gly Ala  Gly Thr Arg Thr Ile  Ala Ser Pro Lys Gly  Pro Val Ile 
    1085                 1090                 1095             


Gln Met  Tyr Thr Asn Val Asp  Gln Asp Leu Val Gly  Trp Pro Ala 
    1100                 1105                 1110             


Pro Gln  Gly Ser Arg Ser Leu  Thr Pro Cys Thr Cys  Gly Ser Ser 
    1115                 1120                 1125             


Asp Leu  Tyr Leu Val Thr Arg  His Ala Asp Val Ile  Pro Val Arg 
    1130                 1135                 1140             


Arg Arg  Gly Asp Ser Arg Gly  Ser Leu Leu Ser Pro  Arg Pro Ile 
    1145                 1150                 1155             


Ser Tyr  Leu Lys Gly Ser Ser  Gly Gly Pro Leu Leu  Cys Pro Ala 
    1160                 1165                 1170             


Gly His  Ala Val Gly Ile Phe  Arg Ala Ala Val Cys  Thr Arg Gly 
    1175                 1180                 1185             


Val Ala  Lys Ala Val Asp Phe  Ile Pro Val Glu Asn  Leu Glu Thr 
    1190                 1195                 1200             


Thr Met  Arg Ser Pro Val Phe  Thr Asp Asn Ser Ser  Pro Pro Val 
    1205                 1210                 1215             


Val Pro  Gln Ser Phe Gln Val  Ala His Leu His Ala  Pro Thr Gly 
    1220                 1225                 1230             


Ser Gly  Lys Ser Thr Lys Val  Pro Ala Ala Tyr Ala  Ala Gln Gly 
    1235                 1240                 1245             


Tyr Lys  Val Leu Val Leu Asn  Pro Ser Val Ala Ala  Thr Leu Gly 
    1250                 1255                 1260             


Phe Gly  Ala Tyr Met Ser Lys  Ala His Gly Ile Asp  Pro Asn Ile 
    1265                 1270                 1275             


Arg Thr  Gly Val Arg Thr Ile  Thr Thr Gly Ser Pro  Ile Thr Tyr 
    1280                 1285                 1290             


Ser Thr  Tyr Gly Lys Phe Leu  Ala Asp Gly Gly Cys  Ser Gly Gly 
    1295                 1300                 1305             


Ala Tyr  Asp Ile Ile Ile Cys  Asp Glu Cys His Ser  Thr Asp Ala 
    1310                 1315                 1320             


Thr Ser  Ile Leu Gly Ile Gly  Thr Val Leu Asp Gln  Ala Glu Thr 
    1325                 1330                 1335             


Ala Gly  Ala Arg Leu Val Val  Leu Ala Thr Ala Thr  Pro Pro Gly 
    1340                 1345                 1350             


Ser Val  Thr Val Pro His Pro  Asn Ile Glu Glu Val  Ala Leu Ser 
    1355                 1360                 1365             


Thr Thr  Gly Glu Ile Pro Phe  Tyr Gly Lys Ala Ile  Pro Leu Glu 
    1370                 1375                 1380             


Val Ile  Lys Gly Gly Arg His  Leu Ile Phe Cys His  Ser Lys Lys 
    1385                 1390                 1395             


Lys Cys  Asp Glu Leu Ala Ala  Lys Leu Val Ala Leu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Val  Ala Tyr Tyr Arg Gly  Leu Asp Val Ser Val  Ile Pro Thr 
    1415                 1420                 1425             


Ser Gly  Asp Val Val Val Val  Ala Thr Asp Ala Leu  Met Thr Gly 
    1430                 1435                 1440             


Tyr Thr  Gly Asp Phe Asp Ser  Val Ile Asp Cys Asn  Thr Cys Val 
    1445                 1450                 1455             


Thr Gln  Thr Val Asp Phe Ser  Leu Asp Pro Thr Phe  Thr Ile Glu 
    1460                 1465                 1470             


Thr Ile  Thr Leu Pro Gln Asp  Ala Val Ser Arg Thr  Gln Arg Arg 
    1475                 1480                 1485             


Gly Arg  Thr Gly Arg Gly Lys  Pro Gly Ile Tyr Arg  Phe Val Ala 
    1490                 1495                 1500             


Pro Gly  Glu Arg Pro Ser Gly  Met Phe Asp Ser Ser  Val Leu Cys 
    1505                 1510                 1515             


Glu Cys  Tyr Asp Ala Gly Cys  Ala Trp Tyr Glu Leu  Thr Pro Ala 
    1520                 1525                 1530             


Glu Thr  Thr Val Arg Leu Arg  Ala Tyr Met Asn Thr  Pro Gly Leu 
    1535                 1540                 1545             


Pro Val  Cys Gln Asp His Leu  Glu Phe Trp Glu Gly  Val Phe Thr 
    1550                 1555                 1560             


Gly Leu  Thr His Ile Asp Ala  His Phe Leu Ser Gln  Thr Lys Gln 
    1565                 1570                 1575             


Ser Gly  Glu Asn Leu Pro Tyr  Leu Val Ala Tyr Gln  Ala Thr Val 
    1580                 1585                 1590             


Cys Ala  Arg Ala Gln Ala Pro  Pro Pro Ser Trp Asp  Gln Met Trp 
    1595                 1600                 1605             


Lys Cys  Leu Ile Arg Leu Lys  Pro Thr Leu His Gly  Pro Thr Pro 
    1610                 1615                 1620             


Leu Leu  Tyr Arg Leu Gly Ala  Val Gln Asn Glu Ile  Thr Leu Thr 
    1625                 1630                 1635             


His Pro  Val Thr Lys Tyr Ile  Met Thr Cys Met Ser  Ala Asp Leu 
    1640                 1645                 1650             


Glu Val  Val Thr Ser Thr Trp  Val Leu Val Gly Gly  Val Leu Ala 
    1655                 1660                 1665             


Ala Leu  Ala Ala Tyr Cys Leu  Ser Thr Gly Cys Val  Val Ile Val 
    1670                 1675                 1680             


Gly Arg  Val Val Leu Ser Gly  Lys Pro Ala Ile Ile  Pro Asp Arg 
    1685                 1690                 1695             


Glu Val  Leu Tyr Arg Glu Phe  Asp Glu Met Glu Glu  Cys Ser Gln 
    1700                 1705                 1710             


His Leu  Pro Tyr Ile Glu Gln  Gly Met Met Leu Ala  Glu Gln Phe 
    1715                 1720                 1725             


Lys Gln  Lys Ala Leu Gly Leu  Leu Gln Thr Ala Ser  Arg Gln Ala 
    1730                 1735                 1740             


Glu Val  Ile Ala Pro Ala Val  Gln Thr Asn Trp Gln  Lys Leu Glu 
    1745                 1750                 1755             


Thr Phe  Trp Ala Lys His Met  Trp Asn Phe Ile Ser  Gly Ile Gln 
    1760                 1765                 1770             


Tyr Leu  Ala Gly Leu Ser Thr  Leu Pro Gly Asn Pro  Ala Ile Ala 
    1775                 1780                 1785             


Ser Leu  Met Ala Phe Thr Ala  Ala Val Thr Ser Pro  Leu Thr Thr 
    1790                 1795                 1800             


Ser Gln  Thr Leu Leu Phe Asn  Ile Leu Gly Gly Trp  Val Ala Ala 
    1805                 1810                 1815             


Gln Leu  Ala Ala Pro Gly Ala  Ala Thr Ala Phe Val  Gly Ala Gly 
    1820                 1825                 1830             


Leu Ala  Gly Ala Ala Ile Gly  Ser Val Gly Leu Gly  Lys Val Leu 
    1835                 1840                 1845             


Ile Asp  Ile Leu Ala Gly Tyr  Gly Ala Gly Val Ala  
    1850                 1855                 1860 


<210>  2
<211>  646
<212>  PRT
<213>  Hepatitis C virus

<400>  2

Met Gly Cys Val Val Ile Val Gly Arg Val Val Leu Ser Gly Ser Gly 
1               5                   10                  15      


Ser Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly Cys Lys 
            20                  25                  30          


Lys Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val 
        35                  40                  45              


Gln Ile Val Ser Thr Ala Ala Gln Thr Phe Leu Ala Thr Cys Ile Asn 
    50                  55                  60                  


Gly Val Cys Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala 
65                  70                  75                  80  


Ser Pro Lys Gly Pro Val Ile Gln Met Tyr Thr Asn Val Asp Gln Asp 
                85                  90                  95      


Leu Val Gly Trp Pro Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys 
            100                 105                 110         


Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val 
        115                 120                 125             


Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro 
    130                 135                 140                 


Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ala Gly Gly Pro Leu Leu Cys 
145                 150                 155                 160 


Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys Thr Arg 
                165                 170                 175     


Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Asn Leu Glu Thr 
            180                 185                 190         


Thr Met Arg Ser Pro Val Phe Thr Asp Asn Ser Ser Pro Pro Val Val 
        195                 200                 205             


Pro Gln Ser Phe Gln Val Ala His Leu His Ala Pro Thr Gly Ser Gly 
    210                 215                 220                 


Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr Lys Val 
225                 230                 235                 240 


Leu Val Leu Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly Ala Tyr 
                245                 250                 255     


Met Ser Lys Ala His Gly Ile Asp Pro Asn Ile Arg Thr Gly Val Arg 
            260                 265                 270         


Thr Ile Thr Thr Gly Ser Pro Ile Thr Tyr Ser Thr Tyr Gly Lys Phe 
        275                 280                 285             


Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile Ile Cys 
    290                 295                 300                 


Asp Glu Cys His Ser Thr Asp Ala Thr Ser Ile Leu Gly Ile Gly Thr 
305                 310                 315                 320 


Val Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg Leu Val Val Leu Ala 
                325                 330                 335     


Thr Ala Thr Pro Pro Gly Ser Val Thr Val Pro His Pro Asn Ile Glu 
            340                 345                 350         


Glu Val Ala Leu Ser Thr Thr Gly Glu Ile Pro Phe Tyr Gly Lys Ala 
        355                 360                 365             


Ile Pro Leu Glu Val Ile Lys Gly Gly Arg His Leu Ile Phe Cys His 
    370                 375                 380                 


Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Val Ala Leu Gly 
385                 390                 395                 400 


Ile Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val Ile Pro 
                405                 410                 415     


Thr Ser Gly Asp Val Val Val Val Ala Thr Asp Ala Leu Met Thr Gly 
            420                 425                 430         


Tyr Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Thr Cys Val Thr 
        435                 440                 445             


Gln Thr Val Asp Phe Ser Leu Asp Pro Thr Phe Thr Ile Glu Thr Ile 
    450                 455                 460                 


Thr Leu Pro Gln Asp Ala Val Ser Arg Thr Gln Arg Arg Gly Arg Thr 
465                 470                 475                 480 


Gly Arg Gly Lys Pro Gly Ile Tyr Arg Phe Val Ala Pro Gly Glu Arg 
                485                 490                 495     


Pro Ser Gly Met Phe Asp Ser Ser Val Leu Cys Glu Cys Tyr Asp Ala 
            500                 505                 510         


Gly Cys Ala Trp Tyr Glu Leu Thr Pro Ala Glu Thr Thr Val Arg Leu 
        515                 520                 525             


Arg Ala Tyr Met Asn Thr Pro Gly Leu Pro Val Cys Gln Asp His Leu 
    530                 535                 540                 


Glu Phe Trp Glu Gly Val Phe Thr Gly Leu Thr His Ile Asp Ala His 
545                 550                 555                 560 


Phe Leu Ser Gln Thr Lys Gln Ser Gly Glu Asn Leu Pro Tyr Leu Val 
                565                 570                 575     


Ala Tyr Gln Ala Thr Val Cys Ala Arg Ala Gln Ala Pro Pro Pro Ser 
            580                 585                 590         


Trp Asp Gln Met Trp Lys Cys Leu Ile Arg Leu Lys Pro Thr Leu His 
        595                 600                 605             


Gly Pro Thr Pro Leu Leu Tyr Arg Leu Gly Ala Val Gln Asn Glu Ile 
    610                 615                 620                 


Thr Leu Thr His Pro Val Thr Lys Tyr Ile Met Thr Cys Met Ser Ala 
625                 630                 635                 640 


Asp Leu Glu Val Val Thr 
                645     


<210>  3
<211>  13
<212>  PRT
<213>  Hepatitis C virus

<400>  3

Gly Cys Val Val Ile Val Gly Arg Val Val Leu Ser Gly 
1               5                   10              


<210>  4
<211>  629
<212>  PRT
<213>  Hepatitis C virus

<400>  4

Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly Cys Lys Lys 
1               5                   10                  15      


Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val Gln 
            20                  25                  30          


Ile Val Ser Thr Ala Ala Gln Thr Phe Leu Ala Thr Cys Ile Asn Gly 
        35                  40                  45              


Val Cys Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala Ser 
    50                  55                  60                  


Pro Lys Gly Pro Val Ile Gln Met Tyr Thr Asn Val Asp Gln Asp Leu 
65                  70                  75                  80  


Val Gly Trp Pro Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys Thr 
                85                  90                  95      


Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val Ile 
            100                 105                 110         


Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg 
        115                 120                 125             


Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu Leu Cys Pro 
    130                 135                 140                 


Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly 
145                 150                 155                 160 


Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Asn Leu Glu Thr Thr 
                165                 170                 175     


Met Arg Ser Pro Val Phe Thr Asp Asn Ser Ser Pro Pro Val Val Pro 
            180                 185                 190         


Gln Ser Phe Gln Val Ala His Leu His Ala Pro Thr Gly Ser Gly Lys 
        195                 200                 205             


Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr Lys Val Leu 
    210                 215                 220                 


Val Leu Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly Ala Tyr Met 
225                 230                 235                 240 


Ser Lys Ala His Gly Ile Asp Pro Asn Ile Arg Thr Gly Val Arg Thr 
                245                 250                 255     


Ile Thr Thr Gly Ser Pro Ile Thr Tyr Ser Thr Tyr Gly Lys Phe Leu 
            260                 265                 270         


Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile Ile Cys Asp 
        275                 280                 285             


Glu Cys His Ser Thr Asp Ala Thr Ser Ile Leu Gly Ile Gly Thr Val 
    290                 295                 300                 


Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg Leu Val Val Leu Ala Thr 
305                 310                 315                 320 


Ala Thr Pro Pro Gly Ser Val Thr Val Pro His Pro Asn Ile Glu Glu 
                325                 330                 335     


Val Ala Leu Ser Thr Thr Gly Glu Ile Pro Phe Tyr Gly Lys Ala Ile 
            340                 345                 350         


Pro Leu Glu Val Ile Lys Gly Gly Arg His Leu Ile Phe Cys His Ser 
        355                 360                 365             


Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Val Ala Leu Gly Ile 
    370                 375                 380                 


Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val Ile Pro Thr 
385                 390                 395                 400 


Ser Gly Asp Val Val Val Val Ala Thr Asp Ala Leu Met Thr Gly Tyr 
                405                 410                 415     


Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Thr Cys Val Thr Gln 
            420                 425                 430         


Thr Val Asp Phe Ser Leu Asp Pro Thr Phe Thr Ile Glu Thr Ile Thr 
        435                 440                 445             


Leu Pro Gln Asp Ala Val Ser Arg Thr Gln Arg Arg Gly Arg Thr Gly 
    450                 455                 460                 


Arg Gly Lys Pro Gly Ile Tyr Arg Phe Val Ala Pro Gly Glu Arg Pro 
465                 470                 475                 480 


Ser Gly Met Phe Asp Ser Ser Val Leu Cys Glu Cys Tyr Asp Ala Gly 
                485                 490                 495     


Cys Ala Trp Tyr Glu Leu Thr Pro Ala Glu Thr Thr Val Arg Leu Arg 
            500                 505                 510         


Ala Tyr Met Asn Thr Pro Gly Leu Pro Val Cys Gln Asp His Leu Glu 
        515                 520                 525             


Phe Trp Glu Gly Val Phe Thr Gly Leu Thr His Ile Asp Ala His Phe 
    530                 535                 540                 


Leu Ser Gln Thr Lys Gln Ser Gly Glu Asn Leu Pro Tyr Leu Val Ala 
545                 550                 555                 560 


Tyr Gln Ala Thr Val Cys Ala Arg Ala Gln Ala Pro Pro Pro Ser Trp 
                565                 570                 575     


Asp Gln Met Trp Lys Cys Leu Ile Arg Leu Lys Pro Thr Leu His Gly 
            580                 585                 590         


Pro Thr Pro Leu Leu Tyr Arg Leu Gly Ala Val Gln Asn Glu Ile Thr 
        595                 600                 605             


Leu Thr His Pro Val Thr Lys Tyr Ile Met Thr Cys Met Ser Ala Asp 
    610                 615                 620                 


Leu Glu Val Val Thr 
625                 


<210>  5
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  5
acaaaacaaa                                                              10


<210>  6
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  6
ctagggtgca agaagaccag cctaac                                            26


<210>  7
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  7
aggctggtct tcttgcacc                                                    19


<210>  8
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  8
tgtcggccga cctggaggtc gtcacgtgat aag                                    33


<210>  9
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  9
tcgacttatc acgtgacgac ctccaggtcg gccgacatgc a                           41


