                         SEQUENCE LISTING

<110>  HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD.
 
<120>  INHIBITORS OF NEUROLIGIN 4 - NEUREXIN 1-BETA PROTEIN-PROTEIN 
       INTERACTION FOR TREATMENT OF LIVER DISORDERS

<130>  HDST 046 PCT

<150>  62/141299
<151>  2015-04-01

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  816
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Arg Pro Gln Gly Leu Leu Trp Leu Pro Leu Leu Phe Thr Pro 
1               5                   10                  15      


Val Cys Val Met Leu Asn Ser Asn Val Leu Leu Trp Leu Thr Ala Leu 
            20                  25                  30          


Ala Ile Lys Phe Thr Leu Ile Asp Ser Gln Ala Gln Tyr Pro Val Val 
        35                  40                  45              


Asn Thr Asn Tyr Gly Lys Ile Arg Gly Leu Arg Thr Pro Leu Pro Asn 
    50                  55                  60                  


Glu Ile Leu Gly Pro Val Glu Gln Tyr Leu Gly Val Pro Tyr Ala Ser 
65                  70                  75                  80  


Pro Pro Thr Gly Glu Arg Arg Phe Gln Pro Pro Glu Pro Pro Ser Ser 
                85                  90                  95      


Trp Thr Gly Ile Arg Asn Thr Thr Gln Phe Ala Ala Val Cys Pro Gln 
            100                 105                 110         


His Leu Asp Glu Arg Ser Leu Leu His Asp Met Leu Pro Ile Trp Phe 
        115                 120                 125             


Thr Ala Asn Leu Asp Thr Leu Met Thr Tyr Val Gln Asp Gln Asn Glu 
    130                 135                 140                 


Asp Cys Leu Tyr Leu Asn Ile Tyr Val Pro Thr Glu Asp Asp Ile His 
145                 150                 155                 160 


Asp Gln Asn Ser Lys Lys Pro Val Met Val Tyr Ile His Gly Gly Ser 
                165                 170                 175     


Tyr Met Glu Gly Thr Gly Asn Met Ile Asp Gly Ser Ile Leu Ala Ser 
            180                 185                 190         


Tyr Gly Asn Val Ile Val Ile Thr Ile Asn Tyr Arg Leu Gly Ile Leu 
        195                 200                 205             


Gly Phe Leu Ser Thr Gly Asp Gln Ala Ala Lys Gly Asn Tyr Gly Leu 
    210                 215                 220                 


Leu Asp Gln Ile Gln Ala Leu Arg Trp Ile Glu Glu Asn Val Gly Ala 
225                 230                 235                 240 


Phe Gly Gly Asp Pro Lys Arg Val Thr Ile Phe Gly Ser Gly Ala Gly 
                245                 250                 255     


Ala Ser Cys Val Ser Leu Leu Thr Leu Ser His Tyr Ser Glu Gly Leu 
            260                 265                 270         


Phe Gln Lys Ala Ile Ile Gln Ser Gly Thr Ala Leu Ser Ser Trp Ala 
        275                 280                 285             


Val Asn Tyr Gln Pro Ala Lys Tyr Thr Arg Ile Leu Ala Asp Lys Val 
    290                 295                 300                 


Gly Cys Asn Met Leu Asp Thr Thr Asp Met Val Glu Cys Leu Arg Asn 
305                 310                 315                 320 


Lys Asn Tyr Lys Glu Leu Ile Gln Gln Thr Ile Thr Pro Ala Thr Tyr 
                325                 330                 335     


His Ile Ala Phe Gly Pro Val Ile Asp Gly Asp Val Ile Pro Asp Asp 
            340                 345                 350         


Pro Gln Ile Leu Met Glu Gln Gly Glu Phe Leu Asn Tyr Asp Ile Met 
        355                 360                 365             


Leu Gly Val Asn Gln Gly Glu Gly Leu Lys Phe Val Asp Gly Ile Val 
    370                 375                 380                 


Asp Asn Glu Asp Gly Val Thr Pro Asn Asp Phe Asp Phe Ser Val Ser 
385                 390                 395                 400 


Asn Phe Val Asp Asn Leu Tyr Gly Tyr Pro Glu Gly Lys Asp Thr Leu 
                405                 410                 415     


Arg Glu Thr Ile Lys Phe Met Tyr Thr Asp Trp Ala Asp Lys Glu Asn 
            420                 425                 430         


Pro Glu Thr Arg Arg Lys Thr Leu Val Ala Leu Phe Thr Asp His Gln 
        435                 440                 445             


Trp Val Ala Pro Ala Val Ala Thr Ala Asp Leu His Ala Gln Tyr Gly 
    450                 455                 460                 


Ser Pro Thr Tyr Phe Tyr Ala Phe Tyr His His Cys Gln Ser Glu Met 
465                 470                 475                 480 


Lys Pro Ser Trp Ala Asp Ser Ala His Gly Asp Glu Val Pro Tyr Val 
                485                 490                 495     


Phe Gly Ile Pro Met Ile Gly Pro Thr Glu Leu Phe Ser Cys Asn Phe 
            500                 505                 510         


Ser Lys Asn Asp Val Met Leu Ser Ala Val Val Met Thr Tyr Trp Thr 
        515                 520                 525             


Asn Phe Ala Lys Thr Gly Asp Pro Asn Gln Pro Val Pro Gln Asp Thr 
    530                 535                 540                 


Lys Phe Ile His Thr Lys Pro Asn Arg Phe Glu Glu Val Ala Trp Ser 
545                 550                 555                 560 


Lys Tyr Asn Pro Lys Asp Gln Leu Tyr Leu His Ile Gly Leu Lys Pro 
                565                 570                 575     


Arg Val Arg Asp His Tyr Arg Ala Thr Lys Val Ala Phe Trp Leu Glu 
            580                 585                 590         


Leu Val Pro His Leu His Asn Leu Asn Glu Ile Phe Gln Tyr Val Ser 
        595                 600                 605             


Thr Thr Thr Lys Val Pro Pro Pro Asp Met Thr Ser Phe Pro Tyr Gly 
    610                 615                 620                 


Thr Arg Arg Ser Pro Ala Lys Ile Trp Pro Thr Thr Lys Arg Pro Ala 
625                 630                 635                 640 


Ile Thr Pro Ala Asn Asn Pro Lys His Ser Lys Asp Pro His Lys Thr 
                645                 650                 655     


Gly Pro Glu Asp Thr Thr Val Leu Ile Glu Thr Lys Arg Asp Tyr Ser 
            660                 665                 670         


Thr Glu Leu Ser Val Thr Ile Ala Val Gly Ala Ser Leu Leu Phe Leu 
        675                 680                 685             


Asn Ile Leu Ala Phe Ala Ala Leu Tyr Tyr Lys Lys Asp Lys Arg Arg 
    690                 695                 700                 


His Glu Thr His Arg Arg Pro Ser Pro Gln Arg Asn Thr Thr Asn Asp 
705                 710                 715                 720 


Ile Ala His Ile Gln Asn Glu Glu Ile Met Ser Leu Gln Met Lys Gln 
                725                 730                 735     


Leu Glu His Asp His Glu Cys Glu Ser Leu Gln Ala His Asp Thr Leu 
            740                 745                 750         


Arg Leu Thr Cys Pro Pro Asp Tyr Thr Leu Thr Leu Arg Arg Ser Pro 
        755                 760                 765             


Asp Asp Ile Pro Leu Met Thr Pro Asn Thr Ile Thr Met Ile Pro Asn 
    770                 775                 780                 


Thr Leu Thr Gly Met Gln Pro Leu His Thr Phe Asn Thr Phe Ser Gly 
785                 790                 795                 800 


Gly Gln Asn Ser Thr Asn Leu Pro His Gly His Ser Thr Thr Arg Val 
                805                 810                 815     


<210>  2
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  2

Gln Gly Glu Phe Leu Asn 
1               5       


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  3

Ser Leu Leu Thr Leu Ser His Tyr Ser Glu 
1               5                   10  


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  4

Ala Gln Tyr Gly Ser Pro Thr Tyr Phe Tyr 
1               5                   10  


<210>  5
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  5

Leu Ser His Tyr Ser Glu Gly Leu Phe Gln Lys 
1               5                   10      


<210>  6
<211>  1547
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gly Thr Ala Leu Leu Gln Arg Gly Gly Cys Phe Leu Leu Cys Leu 
1               5                   10                  15      


Ser Leu Leu Leu Leu Gly Cys Trp Ala Glu Leu Gly Ser Gly Leu Glu 
            20                  25                  30          


Phe Pro Gly Ala Glu Gly Gln Trp Thr Arg Phe Pro Lys Trp Asn Ala 
        35                  40                  45              


Cys Cys Glu Ser Glu Met Ser Phe Gln Leu Lys Thr Arg Ser Ala Arg 
    50                  55                  60                  


Gly Leu Val Leu Tyr Phe Asp Asp Glu Gly Phe Cys Asp Phe Leu Glu 
65                  70                  75                  80  


Leu Ile Leu Thr Arg Gly Gly Arg Leu Gln Leu Ser Phe Ser Ile Phe 
                85                  90                  95      


Cys Ala Glu Pro Ala Thr Leu Leu Ala Asp Thr Pro Val Asn Asp Gly 
            100                 105                 110         


Ala Trp His Ser Val Arg Ile Arg Arg Gln Phe Arg Asn Thr Thr Leu 
        115                 120                 125             


Phe Ile Asp Gln Val Glu Ala Lys Trp Val Glu Val Lys Ser Lys Arg 
    130                 135                 140                 


Arg Asp Met Thr Val Phe Ser Gly Leu Phe Val Gly Gly Leu Pro Pro 
145                 150                 155                 160 


Glu Leu Arg Ala Ala Ala Leu Lys Leu Thr Leu Ala Ser Val Arg Glu 
                165                 170                 175     


Arg Glu Pro Phe Lys Gly Trp Ile Arg Asp Val Arg Val Asn Ser Ser 
            180                 185                 190         


Gln Val Leu Pro Val Asp Ser Gly Glu Val Lys Leu Asp Asp Glu Pro 
        195                 200                 205             


Pro Asn Ser Gly Gly Gly Ser Pro Cys Glu Ala Gly Glu Glu Gly Glu 
    210                 215                 220                 


Gly Gly Val Cys Leu Asn Gly Gly Val Cys Ser Val Val Asp Asp Gln 
225                 230                 235                 240 


Ala Val Cys Asp Cys Ser Arg Thr Gly Phe Arg Gly Lys Asp Cys Ser 
                245                 250                 255     


Gln Glu Ile Lys Phe Gly Leu Gln Cys Val Leu Pro Val Leu Leu His 
            260                 265                 270         


Asp Asn Asp Gln Gly Lys Tyr Cys Cys Ile Asn Thr Ala Lys Pro Leu 
        275                 280                 285             


Thr Glu Lys Asp Asn Asn Val Glu Gly Leu Ala His Leu Met Met Gly 
    290                 295                 300                 


Asp Gln Gly Lys Ser Lys Gly Lys Glu Glu Tyr Ile Ala Thr Phe Lys 
305                 310                 315                 320 


Gly Ser Glu Tyr Phe Cys Tyr Asp Leu Ser Gln Asn Pro Ile Gln Ser 
                325                 330                 335     


Ser Ser Asp Glu Ile Thr Leu Ser Phe Lys Thr Leu Gln Arg Asn Gly 
            340                 345                 350         


Leu Met Leu His Thr Gly Lys Ser Ala Asp Tyr Val Asn Leu Ala Leu 
        355                 360                 365             


Lys Asn Gly Ala Val Ser Leu Val Ile Asn Leu Gly Ser Gly Ala Phe 
    370                 375                 380                 


Glu Ala Leu Val Glu Pro Val Asn Gly Lys Phe Asn Asp Asn Ala Trp 
385                 390                 395                 400 


His Asp Val Lys Val Thr Arg Asn Leu Arg Gln His Ser Gly Ile Gly 
                405                 410                 415     


His Ala Met Val Asn Lys Leu His Cys Ser Val Thr Ile Ser Val Asp 
            420                 425                 430         


Gly Ile Leu Thr Thr Thr Gly Tyr Thr Gln Glu Asp Tyr Thr Met Leu 
        435                 440                 445             


Gly Ser Asp Asp Phe Phe Tyr Val Gly Gly Ser Pro Ser Thr Ala Asp 
    450                 455                 460                 


Leu Pro Gly Ser Pro Val Ser Asn Asn Phe Met Gly Cys Leu Lys Glu 
465                 470                 475                 480 


Val Val Tyr Lys Asn Asn Asp Val Arg Leu Glu Leu Ser Arg Leu Ala 
                485                 490                 495     


Lys Gln Gly Asp Pro Lys Met Lys Ile His Gly Val Val Ala Phe Lys 
            500                 505                 510         


Cys Glu Asn Val Ala Thr Leu Asp Pro Ile Thr Phe Glu Thr Pro Glu 
        515                 520                 525             


Ser Phe Ile Ser Leu Pro Lys Trp Asn Ala Lys Lys Thr Gly Ser Ile 
    530                 535                 540                 


Ser Phe Asp Phe Arg Thr Thr Glu Pro Asn Gly Leu Ile Leu Phe Ser 
545                 550                 555                 560 


His Gly Lys Pro Arg His Gln Lys Asp Ala Lys His Pro Gln Met Ile 
                565                 570                 575     


Lys Val Asp Phe Phe Ala Ile Glu Met Leu Asp Gly His Leu Tyr Leu 
            580                 585                 590         


Leu Leu Asp Met Gly Ser Gly Thr Ile Lys Ile Lys Ala Leu Leu Lys 
        595                 600                 605             


Lys Val Asn Asp Gly Glu Trp Tyr His Val Asp Phe Gln Arg Asp Gly 
    610                 615                 620                 


Arg Ser Gly Thr Ile Ser Val Asn Thr Leu Arg Thr Pro Tyr Thr Ala 
625                 630                 635                 640 


Pro Gly Glu Ser Glu Ile Leu Asp Leu Asp Asp Glu Leu Tyr Leu Gly 
                645                 650                 655     


Gly Leu Pro Glu Asn Lys Ala Gly Leu Val Phe Pro Thr Glu Val Trp 
            660                 665                 670         


Thr Ala Leu Leu Asn Tyr Gly Tyr Val Gly Cys Ile Arg Asp Leu Phe 
        675                 680                 685             


Ile Asp Gly Gln Ser Lys Asp Ile Arg Gln Met Ala Glu Val Gln Ser 
    690                 695                 700                 


Thr Ala Gly Val Lys Pro Ser Cys Ser Lys Glu Thr Ala Lys Pro Cys 
705                 710                 715                 720 


Leu Ser Asn Pro Cys Lys Asn Asn Gly Met Cys Arg Asp Gly Trp Asn 
                725                 730                 735     


Arg Tyr Val Cys Asp Cys Ser Gly Thr Gly Tyr Leu Gly Arg Ser Cys 
            740                 745                 750         


Glu Arg Glu Ala Thr Val Leu Ser Tyr Asp Gly Ser Met Phe Met Lys 
        755                 760                 765             


Ile Gln Leu Pro Val Val Met His Thr Glu Ala Glu Asp Val Ser Leu 
    770                 775                 780                 


Arg Phe Arg Ser Gln Arg Ala Tyr Gly Ile Leu Met Ala Thr Thr Ser 
785                 790                 795                 800 


Arg Asp Ser Ala Asp Thr Leu Arg Leu Glu Leu Asp Ala Gly Arg Val 
                805                 810                 815     


Lys Leu Thr Val Asn Leu Asp Cys Ile Arg Ile Asn Cys Asn Ser Ser 
            820                 825                 830         


Lys Gly Pro Glu Thr Leu Phe Ala Gly Tyr Asn Leu Asn Asp Asn Glu 
        835                 840                 845             


Trp His Thr Val Arg Val Val Arg Arg Gly Lys Ser Leu Lys Leu Thr 
    850                 855                 860                 


Val Asp Asp Gln Gln Ala Met Thr Gly Gln Met Ala Gly Asp His Thr 
865                 870                 875                 880 


Arg Leu Glu Phe His Asn Ile Glu Thr Gly Ile Ile Thr Glu Arg Arg 
                885                 890                 895     


Tyr Leu Ser Ser Val Pro Ser Asn Phe Ile Gly His Leu Gln Ser Leu 
            900                 905                 910         


Thr Phe Asn Gly Met Ala Tyr Ile Asp Leu Cys Lys Asn Gly Asp Ile 
        915                 920                 925             


Asp Tyr Cys Glu Leu Asn Ala Arg Phe Gly Phe Arg Asn Ile Ile Ala 
    930                 935                 940                 


Asp Pro Val Thr Phe Lys Thr Lys Ser Ser Tyr Val Ala Leu Ala Thr 
945                 950                 955                 960 


Leu Gln Ala Tyr Thr Ser Met His Leu Phe Phe Gln Phe Lys Thr Thr 
                965                 970                 975     


Ser Leu Asp Gly Leu Ile Leu Tyr Asn Ser Gly Asp Gly Asn Asp Phe 
            980                 985                 990         


Ile Val Val Glu Leu Val Lys Gly  Tyr Leu His Tyr Val  Phe Asp Leu 
        995                 1000                 1005             


Gly Asn  Gly Ala Asn Leu Ile  Lys Gly Ser Ser Asn  Lys Pro Leu 
    1010                 1015                 1020             


Asn Asp  Asn Gln Trp His Asn  Val Met Ile Ser Arg  Asp Thr Ser 
    1025                 1030                 1035             


Asn Leu  His Thr Val Lys Ile  Asp Thr Lys Ile Thr  Thr Gln Ile 
    1040                 1045                 1050             


Thr Ala  Gly Ala Arg Asn Leu  Asp Leu Lys Ser Asp  Leu Tyr Ile 
    1055                 1060                 1065             


Gly Gly  Val Ala Lys Glu Thr  Tyr Lys Ser Leu Pro  Lys Leu Val 
    1070                 1075                 1080             


His Ala  Lys Glu Gly Phe Gln  Gly Cys Leu Ala Ser  Val Asp Leu 
    1085                 1090                 1095             


Asn Gly  Arg Leu Pro Asp Leu  Ile Ser Asp Ala Leu  Phe Cys Asn 
    1100                 1105                 1110             


Gly Gln  Ile Glu Arg Gly Cys  Glu Gly Pro Ser Thr  Thr Cys Gln 
    1115                 1120                 1125             


Glu Asp  Ser Cys Ser Asn Gln  Gly Val Cys Leu Gln  Gln Trp Asp 
    1130                 1135                 1140             


Gly Phe  Ser Cys Asp Cys Ser  Met Thr Ser Phe Ser  Gly Pro Leu 
    1145                 1150                 1155             


Cys Asn  Asp Pro Gly Thr Thr  Tyr Ile Phe Ser Lys  Gly Gly Gly 
    1160                 1165                 1170             


Gln Ile  Thr Tyr Lys Trp Pro  Pro Asn Asp Arg Pro  Ser Thr Arg 
    1175                 1180                 1185             


Ala Asp  Arg Leu Ala Ile Gly  Phe Ser Thr Val Gln  Lys Glu Ala 
    1190                 1195                 1200             


Val Leu  Val Arg Val Asp Ser  Ser Ser Gly Leu Gly  Asp Tyr Leu 
    1205                 1210                 1215             


Glu Leu  His Ile His Gln Gly  Lys Ile Gly Val Lys  Phe Asn Val 
    1220                 1225                 1230             


Gly Thr  Asp Asp Ile Ala Ile  Glu Glu Ser Asn Ala  Ile Ile Asn 
    1235                 1240                 1245             


Asp Gly  Lys Tyr His Val Val  Arg Phe Thr Arg Ser  Gly Gly Asn 
    1250                 1255                 1260             


Ala Thr  Leu Gln Val Asp Ser  Trp Pro Val Ile Glu  Arg Tyr Pro 
    1265                 1270                 1275             


Ala Gly  Asn Asn Asp Asn Glu  Arg Leu Ala Ile Ala  Arg Gln Arg 
    1280                 1285                 1290             


Ile Pro  Tyr Arg Leu Gly Arg  Val Val Asp Glu Trp  Leu Leu Asp 
    1295                 1300                 1305             


Lys Gly  Arg Gln Leu Thr Ile  Phe Asn Ser Gln Ala  Thr Ile Ile 
    1310                 1315                 1320             


Ile Gly  Gly Lys Glu Gln Gly  Gln Pro Phe Gln Gly  Gln Leu Ser 
    1325                 1330                 1335             


Gly Leu  Tyr Tyr Asn Gly Leu  Lys Val Leu Asn Met  Ala Ala Glu 
    1340                 1345                 1350             


Asn Asp  Ala Asn Ile Ala Ile  Val Gly Asn Val Arg  Leu Val Gly 
    1355                 1360                 1365             


Glu Val  Pro Ser Ser Met Thr  Thr Glu Ser Thr Ala  Thr Ala Met 
    1370                 1375                 1380             


Gln Ser  Glu Met Ser Thr Ser  Ile Met Glu Thr Thr  Thr Thr Leu 
    1385                 1390                 1395             


Ala Thr  Ser Thr Ala Arg Arg  Gly Lys Pro Pro Thr  Lys Glu Pro 
    1400                 1405                 1410             


Ile Ser  Gln Thr Thr Asp Asp  Ile Leu Val Ala Ser  Ala Glu Cys 
    1415                 1420                 1425             


Pro Ser  Asp Asp Glu Asp Ile  Asp Pro Cys Glu Pro  Ser Ser Gly 
    1430                 1435                 1440             


Gly Leu  Ala Asn Pro Thr Arg  Ala Gly Gly Arg Glu  Pro Tyr Pro 
    1445                 1450                 1455             


Gly Ser  Ala Glu Val Ile Arg  Glu Ser Ser Ser Thr  Thr Gly Met 
    1460                 1465                 1470             


Val Val  Gly Ile Val Ala Ala  Ala Ala Leu Cys Ile  Leu Ile Leu 
    1475                 1480                 1485             


Leu Tyr  Ala Met Tyr Lys Tyr  Arg Asn Arg Asp Glu  Gly Ser Tyr 
    1490                 1495                 1500             


His Val  Asp Glu Ser Arg Asn  Tyr Ile Ser Asn Ser  Ala Gln Ser 
    1505                 1510                 1515             


Asn Gly  Ala Val Val Lys Glu  Lys Gln Pro Ser Ser  Ala Lys Ser 
    1520                 1525                 1530             


Ser Asn  Lys Asn Lys Lys Asn  Lys Asp Lys Glu Tyr  Tyr Val 
    1535                 1540                 1545         


<210>  7
<211>  635
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLGn4 extracellular domain

<400>  7

Gln Ala Gln Tyr Pro Val Val Asn Thr Asn Tyr Gly Lys Ile Arg Gly 
1               5                   10                  15      


Leu Arg Thr Pro Leu Pro Asn Glu Ile Leu Gly Pro Val Glu Gln Tyr 
            20                  25                  30          


Leu Gly Val Pro Tyr Ala Ser Pro Pro Thr Gly Glu Arg Arg Phe Gln 
        35                  40                  45              


Pro Pro Glu Pro Pro Ser Ser Trp Thr Gly Ile Arg Asn Thr Thr Gln 
    50                  55                  60                  


Phe Ala Ala Val Cys Pro Gln His Leu Asp Glu Arg Ser Leu Leu His 
65                  70                  75                  80  


Asp Met Leu Pro Ile Trp Phe Thr Ala Asn Leu Asp Thr Leu Met Thr 
                85                  90                  95      


Tyr Val Gln Asp Gln Asn Glu Asp Cys Leu Tyr Leu Asn Ile Tyr Val 
            100                 105                 110         


Pro Thr Glu Asp Asp Ile His Asp Gln Asn Ser Lys Lys Pro Val Met 
        115                 120                 125             


Val Tyr Ile His Gly Gly Ser Tyr Met Glu Gly Thr Gly Asn Met Ile 
    130                 135                 140                 


Asp Gly Ser Ile Leu Ala Ser Tyr Gly Asn Val Ile Val Ile Thr Ile 
145                 150                 155                 160 


Asn Tyr Arg Leu Gly Ile Leu Gly Phe Leu Ser Thr Gly Asp Gln Ala 
                165                 170                 175     


Ala Lys Gly Asn Tyr Gly Leu Leu Asp Gln Ile Gln Ala Leu Arg Trp 
            180                 185                 190         


Ile Glu Glu Asn Val Gly Ala Phe Gly Gly Asp Pro Lys Arg Val Thr 
        195                 200                 205             


Ile Phe Gly Ser Gly Ala Gly Ala Ser Cys Val Ser Leu Leu Thr Leu 
    210                 215                 220                 


Ser His Tyr Ser Glu Gly Leu Phe Gln Lys Ala Ile Ile Gln Ser Gly 
225                 230                 235                 240 


Thr Ala Leu Ser Ser Trp Ala Val Asn Tyr Gln Pro Ala Lys Tyr Thr 
                245                 250                 255     


Arg Ile Leu Ala Asp Lys Val Gly Cys Asn Met Leu Asp Thr Thr Asp 
            260                 265                 270         


Met Val Glu Cys Leu Arg Asn Lys Asn Tyr Lys Glu Leu Ile Gln Gln 
        275                 280                 285             


Thr Ile Thr Pro Ala Thr Tyr His Ile Ala Phe Gly Pro Val Ile Asp 
    290                 295                 300                 


Gly Asp Val Ile Pro Asp Asp Pro Gln Ile Leu Met Glu Gln Gly Glu 
305                 310                 315                 320 


Phe Leu Asn Tyr Asp Ile Met Leu Gly Val Asn Gln Gly Glu Gly Leu 
                325                 330                 335     


Lys Phe Val Asp Gly Ile Val Asp Asn Glu Asp Gly Val Thr Pro Asn 
            340                 345                 350         


Asp Phe Asp Phe Ser Val Ser Asn Phe Val Asp Asn Leu Tyr Gly Tyr 
        355                 360                 365             


Pro Glu Gly Lys Asp Thr Leu Arg Glu Thr Ile Lys Phe Met Tyr Thr 
    370                 375                 380                 


Asp Trp Ala Asp Lys Glu Asn Pro Glu Thr Arg Arg Lys Thr Leu Val 
385                 390                 395                 400 


Ala Leu Phe Thr Asp His Gln Trp Val Ala Pro Ala Val Ala Thr Ala 
                405                 410                 415     


Asp Leu His Ala Gln Tyr Gly Ser Pro Thr Tyr Phe Tyr Ala Phe Tyr 
            420                 425                 430         


His His Cys Gln Ser Glu Met Lys Pro Ser Trp Ala Asp Ser Ala His 
        435                 440                 445             


Gly Asp Glu Val Pro Tyr Val Phe Gly Ile Pro Met Ile Gly Pro Thr 
    450                 455                 460                 


Glu Leu Phe Ser Cys Asn Phe Ser Lys Asn Asp Val Met Leu Ser Ala 
465                 470                 475                 480 


Val Val Met Thr Tyr Trp Thr Asn Phe Ala Lys Thr Gly Asp Pro Asn 
                485                 490                 495     


Gln Pro Val Pro Gln Asp Thr Lys Phe Ile His Thr Lys Pro Asn Arg 
            500                 505                 510         


Phe Glu Glu Val Ala Trp Ser Lys Tyr Asn Pro Lys Asp Gln Leu Tyr 
        515                 520                 525             


Leu His Ile Gly Leu Lys Pro Arg Val Arg Asp His Tyr Arg Ala Thr 
    530                 535                 540                 


Lys Val Ala Phe Trp Leu Glu Leu Val Pro His Leu His Asn Leu Asn 
545                 550                 555                 560 


Glu Ile Phe Gln Tyr Val Ser Thr Thr Thr Lys Val Pro Pro Pro Asp 
                565                 570                 575     


Met Thr Ser Phe Pro Tyr Gly Thr Arg Arg Ser Pro Ala Lys Ile Trp 
            580                 585                 590         


Pro Thr Thr Lys Arg Pro Ala Ile Thr Pro Ala Asn Asn Pro Lys His 
        595                 600                 605             


Ser Lys Asp Pro His Lys Thr Gly Pro Glu Asp Thr Thr Val Leu Ile 
    610                 615                 620                 


Glu Thr Lys Arg Asp Tyr Ser Thr Glu Leu Ser 
625                 630                 635 


<210>  8
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLGn4 intracellular domain

<400>  8

Tyr Lys Lys Asp Lys Arg Arg His Glu Thr His Arg Arg Pro Ser Pro 
1               5                   10                  15      


Gln Arg Asn Thr Thr Asn Asp Ile Ala His Ile Gln Asn Glu Glu Ile 
            20                  25                  30          


Met Ser Leu Gln Met Lys Gln Leu Glu His Asp His Glu Cys Glu Ser 
        35                  40                  45              


Leu Gln Ala His Asp Thr Leu Arg Leu Thr Cys Pro Pro Asp Tyr Thr 
    50                  55                  60                  


Leu Thr Leu Arg Arg Ser Pro Asp Asp Ile Pro Leu Met Thr Pro Asn 
65                  70                  75                  80  


Thr Ile Thr Met Ile Pro Asn Thr Leu Thr Gly Met Gln Pro Leu His 
                85                  90                  95      


Thr Phe Asn Thr Phe Ser Gly Gly Gln Asn Ser Thr Asn Leu Pro His 
            100                 105                 110         


Gly His Ser Thr Thr Arg Val 
        115                 


<210>  9
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLGn4 transmembrane domain

<400>  9

Val Thr Ile Ala Val Gly Ala Ser Leu Leu Phe Leu Asn Ile Leu Ala 
1               5                   10                  15      


Phe Ala Ala Leu Tyr 
            20      


<210>  10
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nrx1b extracellular domain

<400>  10

Ala Ser Ser Leu Gly Ala His His Ile His His Phe His Gly Ser Ser 
1               5                   10                  15      


Lys His His Ser Val Pro Ile Ala Ile Tyr Arg Ser Pro Ala Ser Leu 
            20                  25                  30          


Arg Gly Gly His Ala Gly Thr Thr Tyr Ile Phe Ser Lys Gly Gly Gly 
        35                  40                  45              


Gln Ile Thr Tyr Lys Trp Pro Pro Asn Asp Arg Pro Ser Thr Arg Ala 
    50                  55                  60                  


Asp Arg Leu Ala Ile Gly Phe Ser Thr Val Gln Lys Glu Ala Val Leu 
65                  70                  75                  80  


Val Arg Val Asp Ser Ser Ser Gly Leu Gly Asp Tyr Leu Glu Leu His 
                85                  90                  95      


Ile His Gln Gly Lys Ile Gly Val Lys Phe Asn Val Gly Thr Asp Asp 
            100                 105                 110         


Ile Ala Ile Glu Glu Ser Asn Ala Ile Ile Asn Asp Gly Lys Tyr His 
        115                 120                 125             


Val Val Arg Phe Thr Arg Ser Gly Gly Asn Ala Thr Leu Gln Val Asp 
    130                 135                 140                 


Ser Trp Pro Val Ile Glu Arg Tyr Pro Ala Gly Arg Gln Leu Thr Ile 
145                 150                 155                 160 


Phe Asn Ser Gln Ala Thr Ile Ile Ile Gly Gly Lys Glu Gln Gly Gln 
                165                 170                 175     


Pro Phe Gln Gly Gln Leu Ser Gly Leu Tyr Tyr Asn Gly Leu Lys Val 
            180                 185                 190         


Leu Asn Met Ala Ala Glu Asn Asp Ala Asn Ile Ala Ile Val Gly Asn 
        195                 200                 205             


Val Arg Leu Val Gly Glu Val Pro Ser Ser Met Thr Thr Glu Ser Thr 
    210                 215                 220                 


Ala Thr Ala Met Gln Ser Glu Met Ser Thr Ser Ile Met Glu Thr Thr 
225                 230                 235                 240 


Thr Thr Leu Ala Thr Ser Thr Ala Arg Arg Gly Lys Pro Pro Thr Lys 
                245                 250                 255     


Glu Pro Ile Ser Gln Thr Thr Asp Asp Ile Leu Val Ala Ser Ala Glu 
            260                 265                 270         


Cys Pro Ser Asp Asp Glu Asp Ile Asp Pro Cys Glu Pro Ser Ser Gly 
        275                 280                 285             


Gly Leu Ala Asn Pro Thr Arg Ala Gly Gly Arg Glu Pro Tyr Pro Gly 
    290                 295                 300                 


Ser Ala Glu Val Ile Arg Glu Ser Ser 
305                 310             


<210>  11
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nrx1b intracellular domain

<400>  11

Met Tyr Lys Tyr Arg Asn Arg Asp Glu Gly Ser Tyr His Val Asp Glu 
1               5                   10                  15      


Ser Arg Asn Tyr Ile Ser Asn Ser Ala Gln Ser Asn Gly Ala Val Val 
            20                  25                  30          


Lys Glu Lys Gln Pro Ser Ser Ala Lys Ser Ser Asn Lys Asn Lys Lys 
        35                  40                  45              


Asn Lys Asp Lys Glu Tyr Tyr Val 
    50                  55      


<210>  12
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nrx1b transmembrane domain

<400>  12

Ser Thr Thr Gly Met Val Val Gly Ile Val Ala Ala Ala Ala Leu Cys 
1               5                   10                  15      


Ile Leu Ile Leu Leu Tyr Ala 
            20              


<210>  13
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker peptide

<400>  13

Ile Glu Gly Arg Met Asp 
1               5       


