               SEQUENCE LISTING

<110> VHsquared Limited

<120> Polypeptides

<130> VHS-P1866PC

<160> 76

<170> BiSSAP 1.3

<210> 1
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR1 B4F10arm

<400> 1
Val Tyr Ala Met Gly 
1               5   

<210> 2
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR2 B4F10arm

<400> 2
Thr Ile Asn Arg Ser Gly Ser Asp Ser Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 3
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR3 B4F10arm

<400> 3
Ser His Ser Asp Cys Ile Gly Tyr Gly Cys His His Val Ser Gln Asp 
1               5                   10                  15      
Tyr 
    

<210> 4
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR1 Q34A3arm

<400> 4
His Lys Pro Ala Gly 
1               5   

<210> 5
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR2 Q34A3arm

<400> 5
Ser Ile Thr Thr Arg Ala Ser Thr His Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      



<210> 6
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR1 B14G12arm

<400> 6
Asn Tyr Asn Met Ala 
1               5   

<210> 7
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR2 B14G12arm

<400> 7
Val Ile Thr Trp Thr Gly Gly Ser Thr Tyr Tyr Ala Glu Asp Val Lys 
1               5                   10                  15      
Gly 
    

<210> 8
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR3 B14G12arm

<400> 8
Gly Leu Lys Gly Ser Gly Arg Ser Leu Ser Tyr Pro Asp Gly Tyr Asp 
1               5                   10                  15      
Asn 
    

<210> 9
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR1 B14G3arm

<400> 9
Arg Asn Ala Ala Gly 
1               5   

<210> 10
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR2 B14G3arm

<400> 10
Thr Leu Ser Ser Gly Gly Asn Thr Thr Tyr Arg Asp Ser Val Lys Gly 
1               5                   10                  15      



<210> 11
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR1 Q30A5

<400> 11
Thr Tyr Asp Met Ser 
1               5   

<210> 12
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR2 Q30A5arm

<400> 12
Ala Ile Asn Pro Gly Gly Thr Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 13
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR3 Q30A5arm

<400> 13
Ser Tyr Ala Ser Gly Ile Asp Tyr Tyr Pro Pro Pro Arg Asp Ser 
1               5                   10                  15  

<210> 14
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> B4F10arm

<400> 14
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Thr Ser Asp Val Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Thr Ile Asn Arg Ser Gly Ser Asp Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Glu Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser His Ser Asp Cys Ile Gly Tyr Gly Cys His His Val Ser 
            100                 105                 110         
Gln Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210> 15
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> Q34A3arm

<400> 15
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ile Ser Gly Met Asp Phe Ser His Lys 
            20                  25                  30          
Pro Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ser Ile Thr Thr Arg Ala Ser Thr His Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      
Ser Glu Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110     

<210> 16
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> B14G12arm

<400> 16
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Ser Ile Ser Asn Tyr 
            20                  25                  30          
Asn Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              
Ala Val Ile Thr Trp Thr Gly Gly Ser Thr Tyr Tyr Ala Glu Asp Val 
    50                  55                  60                  
Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Phe 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      
Ala Ala Gly Leu Lys Gly Ser Gly Arg Ser Leu Ser Tyr Pro Asp Gly 
            100                 105                 110         
Tyr Asp Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210> 17
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> B14G3arm

<400> 17
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly His Ile Phe Ser Arg Asn 
            20                  25                  30          
Ala Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Ala Val 
        35                  40                  45              
Ala Thr Leu Ser Ser Gly Gly Asn Thr Thr Tyr Arg Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asp Thr Thr Asn Thr Val His Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      
Ala Met Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110     

<210> 18
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Q30A5arm

<400> 18
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr Tyr 
            20                  25                  30          
Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Pro Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Asn Pro Gly Gly Thr Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asp Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Pro Ser Tyr Ala Ser Gly Ile Asp Tyr Tyr Pro Pro Pro Arg Asp 
            100                 105                 110         
Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 

<210> 19
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> B4F10

<400> 19
Gln Val Gln Leu Gln Glu Thr Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Asp Val Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Thr Ile Asn Arg Ser Gly Ser Asp Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Glu Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Arg Ser Asp Cys Ile Gly Tyr Gly Cys Arg Arg Val Ser 
            100                 105                 110         
Gln Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210> 20
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> B1A7

<400> 20
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Arg Thr Ser Ser Ile Tyr 
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Gly Thr Ser Arg Ser Gly Thr Gly Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Glu Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Arg Ser Asp Cys Leu Gly Val Gly Cys Arg Arg Val Pro 
            100                 105                 110         
Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210> 21
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> B2H11

<400> 21
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Asp Asp Val Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Thr Ile Asn Arg Ser Gly Ser Asp Ser Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Glu Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Arg Ser Asp Cys Ile Gly Tyr Gly Cys Arg Arg Val Pro 
            100                 105                 110         
Gln Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210> 22
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> B3D5

<400> 22
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gln Thr Phe Asp Val Tyr 
            20                  25                  30          
Gly Met Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Gly Thr Ser Arg Ser Gly Thr Gly Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Glu Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Arg Ser Asp Cys Leu Gly Val Gly Cys Arg Arg Val Pro 
            100                 105                 110         
Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210> 23
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> B3H7

<400> 23
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly His Thr Ser Asp Val Tyr 
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Thr Ile Asn Arg Ser Gly Ser Asp Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Glu Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Arg Ser Asp Cys Leu Gly Ile Gly Cys Arg Arg Val Pro 
            100                 105                 110         
His Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210> 24
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> B3H11

<400> 24
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Asp Asp Val Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Thr Ile Asn Arg Ser Gly Ser Asp Ser Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Glu Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Arg Ser Asp Cys Ile Gly Tyr Gly Cys Arg Arg Val Pro 
            100                 105                 110         
Gln Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210> 25
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> B4F5

<400> 25
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Val Ala Ser Gly Arg Thr Ser Asp Val Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Thr Ile Asn Arg Ser Gly Ser Asp Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Glu Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Arg Ser Asp Cys Ile Gly Tyr Gly Cys Arg Arg Val Ser 
            100                 105                 110         
His Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210> 26
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> B4F7

<400> 26
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly His Thr Ser Asp Val Tyr 
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Thr Ile Asn Arg Ser Gly Thr Asp Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Glu Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Arg Ser Asp Cys Leu Gly Ile Gly Cys Arg Arg Val Pro 
            100                 105                 110         
His Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210> 27
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> B4G7

<400> 27
Gln Val Gln Leu Gln Glu Thr Gly Gly Gly Leu Val His Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly His Thr Ser Asp Val Tyr 
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Thr Ile Asn Arg Ser Gly Ser Asp Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Glu Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Arg Ser Asp Cys Leu Gly Ile Gly Cys Arg Arg Val Pro 
            100                 105                 110         
His Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210> 28
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> B4H7

<400> 28
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Asp Asp Val Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Thr Ile Ser Arg Gly Gly Ser Asp Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Glu Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Arg Ser Asp Cys Leu Gly Asn Gly Cys Arg Arg Val Pro 
            100                 105                 110         
Gln Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210> 29
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> Q34A3

<400> 29
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ile Ser Gly Met Asp Phe Ser His Lys 
            20                  25                  30          
Pro Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ser Ile Thr Thr Arg Ala Ser Thr His Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys Asn 
                85                  90                  95      
Ser Glu Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110     

<210> 30
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> B14G12

<400> 30
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Ser Ile Ser Asn Tyr 
            20                  25                  30          
Asn Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              
Ala Val Ile Thr Trp Thr Gly Gly Ser Thr Tyr Tyr Ala Glu Asp Val 
    50                  55                  60                  
Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Phe 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      
Ala Ala Gly Leu Lys Gly Ser Gly Arg Ser Leu Ser Tyr Pro Asp Gly 
            100                 105                 110         
Tyr Asp Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210> 31
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> B14G3

<400> 31
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly His Ile Phe Ser Arg Asn 
            20                  25                  30          
Ala Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Ala Val 
        35                  40                  45              
Ala Thr Leu Ser Ser Gly Gly Asn Thr Thr Tyr Arg Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asp Thr Thr Asn Thr Val His Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      
Ala Met Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110     

<210> 32
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Q30A5

<400> 32
Arg Gly Ala Ala Gly Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr Tyr 
            20                  25                  30          
Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Pro Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Asn Pro Gly Gly Thr Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asp Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Pro Ser Tyr Ala Ser Gly Ile Asp Tyr Tyr Pro Pro Pro Arg Asp 
            100                 105                 110         
Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 

<210> 33
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> ID1A

<400> 33
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ile Ser Gly Met Asp Phe Ser His Lys 
            20                  25                  30          
Pro Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ser Ile Thr Thr Arg Ala Ser Thr His Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys Asn 
                85                  90                  95      
Ser Glu Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110     

<210> 34
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> ID2A

<400> 34
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ile Ser Gly Met Asp Phe Ser His Lys 
            20                  25                  30          
Pro Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ser Ile Thr Thr Arg Ala Ser Thr His Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys Asn 
                85                  90                  95      
Ser Glu Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110     

<210> 35
<211> 242
<212> PRT
<213> Artificial Sequence

<220> 
<223> ID3A

<400> 35
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ile Ser Gly Met Asp Phe Ser His Lys 
            20                  25                  30          
Pro Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ser Ile Thr Thr Arg Ala Ser Thr His Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys Asn 
                85                  90                  95      
Ser Glu Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
            100                 105                 110         
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 
Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ile Ser Gly Met Asp Phe 
145                 150                 155                 160 
Ser His Lys Pro Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
                165                 170                 175     
Glu Phe Val Ala Ser Ile Thr Thr Arg Ala Ser Thr His Tyr Ala Asp 
            180                 185                 190         
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
        195                 200                 205             
Val Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
    210                 215                 220                 
Ser Cys Asn Ser Glu Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
225                 230                 235                 240 
Ser Ser 
        

<210> 36
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> ID10A

<400> 36
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ile Ser Gly Met Asp Phe Ser His Lys 
            20                  25                  30          
Pro Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ser Ile Thr Thr Arg Ala Ser Thr His Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      
Ser Glu Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110     

<210> 37
<211> 257
<212> PRT
<213> Artificial Sequence

<220> 
<223> ID11A

<400> 37
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Ser Ile Ser Asn Tyr 
            20                  25                  30          
Asn Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              
Ala Val Ile Thr Trp Thr Gly Gly Ser Thr Tyr Tyr Ala Glu Asp Val 
    50                  55                  60                  
Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Phe 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      
Ala Ala Gly Leu Lys Gly Ser Gly Arg Ser Leu Ser Tyr Pro Asp Gly 
            100                 105                 110         
Tyr Asp Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro 
145                 150                 155                 160 
Gly Gly Ser Leu Arg Leu Ser Cys Val Ile Ser Gly Met Asp Phe Ser 
                165                 170                 175     
His Lys Pro Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
            180                 185                 190         
Phe Val Ala Ser Ile Thr Thr Arg Ala Ser Thr His Tyr Ala Asp Ser 
        195                 200                 205             
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
    210                 215                 220                 
Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser 
225                 230                 235                 240 
Cys Asn Ser Glu Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                245                 250                 255     
Ser 
    

<210> 38
<211> 257
<212> PRT
<213> Artificial Sequence

<220> 
<223> ID12A

<400> 38
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Asp Val Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Thr Ile Asn Arg Ser Gly Ser Asp Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Glu Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Arg Ser Asp Cys Ile Gly Tyr Gly Cys Arg Arg Val Ser 
            100                 105                 110         
Gln Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro 
145                 150                 155                 160 
Gly Gly Ser Leu Arg Leu Ser Cys Val Ile Ser Gly Met Asp Phe Ser 
                165                 170                 175     
His Lys Pro Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
            180                 185                 190         
Phe Val Ala Ser Ile Thr Thr Arg Ala Ser Thr His Tyr Ala Asp Ser 
        195                 200                 205             
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
    210                 215                 220                 
Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser 
225                 230                 235                 240 
Cys Asn Ser Glu Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                245                 250                 255     
Ser 
    

<210> 39
<211> 242
<212> PRT
<213> Artificial Sequence

<220> 
<223> ID13A

<400> 39
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly His Ile Phe Ser Arg Asn 
            20                  25                  30          
Ala Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Ala Val 
        35                  40                  45              
Ala Thr Leu Ser Ser Gly Gly Asn Thr Thr Tyr Arg Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asp Thr Thr Asn Thr Val His Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      
Ala Met Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
            100                 105                 110         
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 
Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ile Ser Gly Met Asp Phe 
145                 150                 155                 160 
Ser His Lys Pro Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
                165                 170                 175     
Glu Phe Val Ala Ser Ile Thr Thr Arg Ala Ser Thr His Tyr Ala Asp 
            180                 185                 190         
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
        195                 200                 205             
Val Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
    210                 215                 220                 
Ser Cys Asn Ser Glu Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
225                 230                 235                 240 
Ser Ser 
        

<210> 40
<211> 255
<212> PRT
<213> Artificial Sequence

<220> 
<223> ID15A

<400> 40
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr Tyr 
            20                  25                  30          
Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Pro Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Asn Pro Gly Gly Thr Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asp Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Pro Ser Tyr Ala Ser Gly Ile Asp Tyr Tyr Pro Pro Pro Arg Asp 
            100                 105                 110         
Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
145                 150                 155                 160 
Ser Leu Arg Leu Ser Cys Val Ile Ser Gly Met Asp Phe Ser His Lys 
                165                 170                 175     
Pro Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
            180                 185                 190         
Ala Ser Ile Thr Thr Arg Ala Ser Thr His Tyr Ala Asp Ser Val Lys 
        195                 200                 205             
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
    210                 215                 220                 
Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys Asn 
225                 230                 235                 240 
Ser Glu Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250                 255 

<210> 41
<211> 257
<212> PRT
<213> Artificial Sequence

<220> 
<223> ID17A

<400> 41
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Thr Ser Asp Val Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Thr Ile Asn Arg Ser Gly Ser Asp Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Glu Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Arg Ser Asp Cys Ile Gly Tyr Gly Cys Arg Arg Val Ser 
            100                 105                 110         
Gln Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala 
145                 150                 155                 160 
Gly Gly Ser Leu Arg Leu Ser Cys Val Ile Ser Gly Met Asp Phe Ser 
                165                 170                 175     
His Lys Pro Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
            180                 185                 190         
Phe Val Ala Ser Ile Thr Thr Arg Ala Ser Thr His Tyr Ala Asp Ser 
        195                 200                 205             
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
    210                 215                 220                 
Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
225                 230                 235                 240 
Cys Asn Ser Glu Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                245                 250                 255     
Ser 
    

<210> 42
<211> 257
<212> PRT
<213> Artificial Sequence

<220> 
<223> ID29A

<400> 42
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Thr Ser Asp Val Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Thr Ile Asn Arg Ser Gly Ser Asp Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Glu Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Arg Ser Asp Cys Ile Gly Tyr Gly Cys His Arg Val Ser 
            100                 105                 110         
Gln Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala 
145                 150                 155                 160 
Gly Gly Ser Leu Arg Leu Ser Cys Val Ile Ser Gly Met Asp Phe Ser 
                165                 170                 175     
His Lys Pro Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
            180                 185                 190         
Phe Val Ala Ser Ile Thr Thr Arg Ala Ser Thr His Tyr Ala Asp Ser 
        195                 200                 205             
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
    210                 215                 220                 
Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
225                 230                 235                 240 
Cys Asn Ser Glu Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                245                 250                 255     
Ser 
    

<210> 43
<211> 257
<212> PRT
<213> Artificial Sequence

<220> 
<223> ID30A

<400> 43
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Thr Ser Asp Val Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Thr Ile Asn Arg Ser Gly Ser Asp Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Glu Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Arg Ser Asp Cys Ile Gly Tyr Gly Cys Arg His Val Ser 
            100                 105                 110         
Gln Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala 
145                 150                 155                 160 
Gly Gly Ser Leu Arg Leu Ser Cys Val Ile Ser Gly Met Asp Phe Ser 
                165                 170                 175     
His Lys Pro Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
            180                 185                 190         
Phe Val Ala Ser Ile Thr Thr Arg Ala Ser Thr His Tyr Ala Asp Ser 
        195                 200                 205             
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
    210                 215                 220                 
Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
225                 230                 235                 240 
Cys Asn Ser Glu Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                245                 250                 255     
Ser 
    

<210> 44
<211> 257
<212> PRT
<213> Artificial Sequence

<220> 
<223> ID31A

<400> 44
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Thr Ser Asp Val Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Thr Ile Asn Arg Ser Gly Ser Asp Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Glu Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Arg Ser Asp Cys Ile Gly Tyr Gly Cys His His Val Ser 
            100                 105                 110         
Gln Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala 
145                 150                 155                 160 
Gly Gly Ser Leu Arg Leu Ser Cys Val Ile Ser Gly Met Asp Phe Ser 
                165                 170                 175     
His Lys Pro Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
            180                 185                 190         
Phe Val Ala Ser Ile Thr Thr Arg Ala Ser Thr His Tyr Ala Asp Ser 
        195                 200                 205             
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
    210                 215                 220                 
Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
225                 230                 235                 240 
Cys Asn Ser Glu Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                245                 250                 255     
Ser 
    

<210> 45
<211> 257
<212> PRT
<213> Artificial Sequence

<220> 
<223> ID32A

<400> 45
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Thr Ser Asp Val Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Thr Ile Asn Arg Ser Gly Ser Asp Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Glu Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser His Ser Asp Cys Ile Gly Tyr Gly Cys Arg Arg Val Ser 
            100                 105                 110         
Gln Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala 
145                 150                 155                 160 
Gly Gly Ser Leu Arg Leu Ser Cys Val Ile Ser Gly Met Asp Phe Ser 
                165                 170                 175     
His Lys Pro Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
            180                 185                 190         
Phe Val Ala Ser Ile Thr Thr Arg Ala Ser Thr His Tyr Ala Asp Ser 
        195                 200                 205             
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
    210                 215                 220                 
Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
225                 230                 235                 240 
Cys Asn Ser Glu Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                245                 250                 255     
Ser 
    

<210> 46
<211> 257
<212> PRT
<213> Artificial Sequence

<220> 
<223> ID33A

<400> 46
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Thr Ser Asp Val Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Thr Ile Asn Arg Ser Gly Ser Asp Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Glu Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser His Ser Asp Cys Ile Gly Tyr Gly Cys His His Val Ser 
            100                 105                 110         
Gln Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala 
145                 150                 155                 160 
Gly Gly Ser Leu Arg Leu Ser Cys Val Ile Ser Gly Met Asp Phe Ser 
                165                 170                 175     
His Lys Pro Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
            180                 185                 190         
Phe Val Ala Ser Ile Thr Thr Arg Ala Ser Thr His Tyr Ala Asp Ser 
        195                 200                 205             
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
    210                 215                 220                 
Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
225                 230                 235                 240 
Cys Asn Ser Glu Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                245                 250                 255     
Ser 
    

<210> 47
<211> 257
<212> PRT
<213> Artificial Sequence

<220> 
<223> ID34A

<400> 47
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Thr Ser Asp Val Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Thr Ile Asn Arg Ser Gly Ser Asp Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Glu Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Arg Ser Asp Cys Ile Gly His Gly Cys His Arg Val Ser 
            100                 105                 110         
Gln Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala 
145                 150                 155                 160 
Gly Gly Ser Leu Arg Leu Ser Cys Val Ile Ser Gly Met Asp Phe Ser 
                165                 170                 175     
His Lys Pro Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
            180                 185                 190         
Phe Val Ala Ser Ile Thr Thr Arg Ala Ser Thr His Tyr Ala Asp Ser 
        195                 200                 205             
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
    210                 215                 220                 
Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
225                 230                 235                 240 
Cys Asn Ser Glu Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                245                 250                 255     
Ser 
    

<210> 48
<211> 257
<212> PRT
<213> Artificial Sequence

<220> 
<223> ID35A

<400> 48
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Thr Ser Asp Val Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Thr Ile Asn Arg Ser Gly Ser Asp Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Glu Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser His Ser Asp Cys Ile Gly Tyr Gly Cys His His Val Ser 
            100                 105                 110         
Gln Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
145                 150                 155                 160 
Gly Gly Ser Leu Arg Leu Ser Cys Val Ile Ser Gly Met Asp Phe Ser 
                165                 170                 175     
His Lys Pro Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
            180                 185                 190         
Phe Val Ala Ser Ile Thr Thr Arg Ala Ser Thr His Tyr Ala Asp Ser 
        195                 200                 205             
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
    210                 215                 220                 
Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
225                 230                 235                 240 
Cys Asn Ser Glu Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                245                 250                 255     
Ser 
    

<210> 49
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> 3' primer

<400> 49
tcttaactag tgaggagacg gtgacctg                                       28


<210> 50
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> M13.rev

<400> 50
caggaaacag ctatgac                                                   17


<210> 51
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> M13.fw

<400> 51
gtaaaacgac ggccag                                                    16


<210> 52
<211> 339
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding ID1A

<400> 52
gatgtgcagc tgcaggagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc      60

tcctgtgtaa tctctggaat ggacttcagt cacaaacccg cgggctggtt ccgccaggct     120

ccaggaaaag agcgcgagtt cgtcgcttcg attacgactc gtgctagcac gcactatgca     180

gactccgtga agggccgatt caccatctcc agagacaacg ccaagaacac ggtatatcta     240

gaaatgaaca gcctgaaacc tgaggacacg gccgtctatt cttgtaactc cgaatactac     300

tggggccagg ggacccaggt caccgtctcc tcataatga                            339


<210> 53
<211> 339
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding ID2A

<400> 53
gatgtgcagc tgcaggagtc tgggggaggc ttggtgcagg ctggggggtc tctgagactc      60

tcctgtgtaa tctctggaat ggacttcagt cacaaacccg cgggctggtt ccgccaggct     120

ccaggaaaag agcgcgagtt cgtcgcttcg attacgactc gtgctagcac gcactatgca     180

gactccgtga agggccgatt caccatctcc agagacaacg ccaagaacac ggtatatcta     240

gaaatgaaca gcctgaaacc tgaggacacg gccgtctatt cttgtaactc cgaatactac     300

tggggccagg ggacccaggt caccgtctcc tcataatga                            339


<210> 54
<211> 339
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding ID10A

<400> 54
gatgtgcagc tgcaggagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc      60

tcctgtgtaa tctctggaat ggacttcagt cacaaacccg cgggctggtt ccgccaggct     120

ccaggaaaag agcgcgagtt cgtcgcttcg attacgactc gtgctagcac gcactatgca     180

gactccgtga agggccgatt caccatctcc agagacaacg ccaagaacac ggtatatcta     240

gaaatgaaca gcctgaaacc tgaggacacg gccgtctatt attgtaactc cgaatactac     300

tggggccagg ggacccaggt caccgtctcc tcataatga                            339


<210> 55
<211> 777
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding ID11A

<400> 55
gatgtgcagc tgcaggagtc cgggggagga ttggtgcagg ctgggggctc tctgagactc      60

tcctgtgcag cctctggact cagcatcagt aactataaca tggcctggtt ccgccaggct     120

ccagggaagg agcgtgagtt ggtagcagtg attacctgga ctggcggtag cacatactat     180

gcagaggacg tgaagggccg actcaccatc tccagagaca acgccaagaa cacggtgttt     240

ctccagatga acagcctgaa acctgaggac acggccattt acttctgtgc agcaggatta     300

aagggtagtg gccggtccct aagttatccg gatggttatg acaactgggg ccaggggacc     360

caggtcaccg tctcctcagg tggaggcggt tcaggcggag gtggctctgg cggtggcgga     420

agtggtggag gcggttcaga tgtgcagctg caggagtctg ggggaggctt ggtgcagcct     480

ggggggtctc tgagactctc ctgtgtaatc tctggaatgg acttcagtca caaacccgcg     540

ggctggttcc gccaggctcc aggaaaagag cgcgagttcg tcgcttcgat tacgactcgt     600

gctagcacgc actatgcaga ctccgtgaag ggccgattca ccatctccag agacaacgcc     660

aagaacacgg tatatctaga aatgaacagc ctgaaacctg aggacacggc cgtctattct     720

tgtaactccg aatactactg gggccagggg acccaggtca ccgtctcctc ataatga        777


<210> 56
<211> 777
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding ID12A

<400> 56
gatgtgcagc tgcaggagtc tgggggagga ttggtgcagg ctgggggctc tctgagactc      60

tcctgtgcag cctctggacg caccagcgat gtctatgcca tgggctggtt ccgccaggtt     120

ccaggaaagg agcgcgaatt tgtagcgact attaaccgga gtggtagtga ctcatactat     180

gcggactccg tgaagggccg gttcaccatc tccagagaca acgccaagaa cacggtgtat     240

ctgcaaatga acagcctgaa acctgaggaa acggccgttt attactgtgc ggcctctagg     300

agcgactgta taggttatgg gtgtcgtcgc gtctcgcaag actactgggg ccaggggacc     360

caggtcaccg tctcctcagg tggaggcggt tcaggcggag gtggctctgg cggtggcgga     420

agtggtggag gcggttcaga tgtgcagctg caggagtctg ggggaggctt ggtgcagcct     480

ggggggtctc tgagactctc ctgtgtaatc tctggaatgg acttcagtca caaacccgcg     540

ggctggttcc gccaggctcc aggaaaagag cgcgagttcg tcgcttcgat tacgactcgt     600

gctagcacgc actatgcaga ctccgtgaag ggccgattca ccatctccag agacaacgcc     660

aagaacacgg tatatctaga aatgaacagc ctgaaacctg aggacacggc cgtctattct     720

tgtaactccg aatactactg gggccagggg acccaggtca ccgtctcctc ataatga        777


<210> 57
<211> 732
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding ID13A

<400> 57
gatgtgcagc tgcaggagtc cgggggaggc ttggtgcagg ctggggggtc tctgagactc      60

tcctgtgcag cctcgggaca catcttcagt cgcaatgccg cgggctggtt ccgccaggct     120

ccagggaagc agcgcgaggc ggtcgcgaca ctaagtagtg gtggaaatac aacctatcga     180

gactccgtga agggccgatt caccatctcc agagacgaca ccacgaacac ggtgcatctg     240

caaatgaaca gcctgaaacc tgaggacacg gccgtctatt actgtaatgc tatgtggtac     300

tggggccagg ggacccaggt caccgtctcc tcaggtggag gcggttcagg cggaggtggc     360

tctggcggtg gcggaagtgg tggaggcggt tcagatgtgc agctgcagga gtctggggga     420

ggcttggtgc agcctggggg gtctctgaga ctctcctgtg taatctctgg aatggacttc     480

agtcacaaac ccgcgggctg gttccgccag gctccaggaa aagagcgcga gttcgtcgct     540

tcgattacga ctcgtgctag cacgcactat gcagactccg tgaagggccg attcaccatc     600

tccagagaca acgccaagaa cacggtatat ctagaaatga acagcctgaa acctgaggac     660

acggccgtct attcttgtaa ctccgaatac tactggggcc aggggaccca ggtcaccgtc     720

tcctcataat ga                                                         732


<210> 58
<211> 771
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding ID15A

<400> 58
gatgtgcagc tgcaggagtc tgggggaggc ttggtgcagc ctgggggttc tctgaaactc      60

tcctgtgcag cctccggatt caccttcggg acgtatgaca tgagctgggt ccgccaggct     120

ccaggaaaga ggcccgagtg ggtctcagcg attaatccgg gtggtactag cacatactat     180

gcagactccg tgaagggccg attcaccgtc tccagagaca acgccaagga cacgctgtat     240

ctgcaaatga acagcctgaa acctgaggac acggccgtgt attactgtac tccgtcatac     300

gctagtggta ttgactacta cccccccccg cgagattcct ggggccaggg gacccaggtc     360

accgtctcct caggtggagg cggttcaggc ggaggtggct ctggcggtgg cggaagtggt     420

ggaggcggtt cagatgtgca gctgcaggag tctgggggag gcttggtgca gcctgggggg     480

tctctgagac tctcctgtgt aatctctgga atggacttca gtcacaaacc cgcgggctgg     540

ttccgccagg ctccaggaaa agagcgcgag ttcgtcgctt cgattacgac tcgtgctagc     600

acgcactatg cagactccgt gaagggccga ttcaccatct ccagagacaa cgccaagaac     660

acggtatatc tagaaatgaa cagcctgaaa cctgaggaca cggccgtcta ttcttgtaac     720

tccgaatact actggggcca ggggacccag gtcaccgtct cctcataatg a              771


<210> 59
<211> 777
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding ID17A

<400> 59
gatgtgcagc tgcaggagtc tgggggagga ttggtgcagg ctgggggctc tctgagactc      60

tcctgtgcag cctctggagc taccagcgat gtctatgcca tgggctggtt ccgccaggtt     120

ccaggaaagg agcgcgaatt tgtagcgact attaaccgga gtggtagtga ctcatactat     180

gcggactccg tgaagggccg gttcaccatc tccagagaca acgccaagaa cacggtgtat     240

ctgcaaatga acagcctgaa acctgaggaa acggccgttt attactgtgc ggcctctagg     300

agcgactgta taggttatgg gtgtcgtcgc gtctcgcaag actactgggg ccaggggacc     360

caggtcaccg tctcctcagg tggaggcggt tcaggcggag gtggctctgg cggtggcgga     420

agtggtggag gcggttcaga tgtgcagctg caggagtctg ggggaggctt ggtgcaggct     480

ggggggtctc tgagactctc ctgtgtaatc tctggaatgg acttcagtca caaacccgcg     540

ggctggttcc gccaggctcc aggaaaagag cgcgagttcg tcgcttcgat tacgactcgt     600

gctagcacgc actatgcaga ctccgtgaag ggccgattca ccatctccag agacaacgcc     660

aagaacacgg tatatctaga aatgaacagc ctgaaacctg aggacacggc cgtctattat     720

tgtaactccg aatactactg gggccagggg acccaggtca ccgtctcctc ataatga        777


<210> 60
<211> 777
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding ID33A

<400> 60
gatgtgcagc tgcaggagtc tgggggagga ttggtgcagg ctgggggctc tctgagactc      60

tcctgtgcag cctctggagc taccagcgat gtctatgcca tgggctggtt ccgccaggtt     120

ccaggaaagg agcgcgaatt tgtagcgact attaaccgga gtggtagtga ctcatactat     180

gcggactccg tgaagggccg gttcaccatc tccagagaca acgccaagaa cacggtgtat     240

ctgcaaatga acagcctgaa acctgaggaa acggccgttt attactgtgc ggcctctcat     300

agcgactgta taggttatgg gtgtcatcac gtctcgcaag actactgggg ccaggggacc     360

caggtcaccg tctcctcagg tggaggcggt tcaggcggag gtggctctgg cggtggcgga     420

agtggtggag gcggttcaga tgtgcagctg caggagtctg ggggaggctt ggtgcaggct     480

ggggggtctc tgagactctc ctgtgtaatc tctggaatgg acttcagtca caaacccgcg     540

ggctggttcc gccaggctcc aggaaaagag cgcgagttcg tcgcttcgat tacgactcgt     600

gctagcacgc actatgcaga ctccgtgaag ggccgattca ccatctccag agacaacgcc     660

aagaacacgg tatatctaga aatgaacagc ctgaaacctg aggacacggc cgtctattat     720

tgtaactccg aatactactg gggccagggg acccaggtca ccgtctcctc ataatga        777


<210> 61
<211> 339
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding Q34A3arm (in ID33A)

<400> 61
gatgtgcagc tgcaggagtc tgggggaggc ttggtgcagg ctggggggtc tctgagactc      60

tcctgtgtaa tctctggaat ggacttcagt cacaaacccg cgggctggtt ccgccaggct     120

ccaggaaaag agcgcgagtt cgtcgcttcg attacgactc gtgctagcac gcactatgca     180

gactccgtga agggccgatt caccatctcc agagacaacg ccaagaacac ggtatatcta     240

gaaatgaaca gcctgaaacc tgaggacacg gccgtctatt attgtaactc cgaatactac     300

tggggccagg ggacccaggt caccgtctcc tcataatga                            339


<210> 62
<211> 384
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding B4F10arm (in ID33A)

<400> 62
gatgtgcagc tgcaggagtc tgggggagga ttggtgcagg ctgggggctc tctgagactc      60

tcctgtgcag cctctggagc taccagcgat gtctatgcca tgggctggtt ccgccaggtt     120

ccaggaaagg agcgcgaatt tgtagcgact attaaccgga gtggtagtga ctcatactat     180

gcggactccg tgaagggccg gttcaccatc tccagagaca acgccaagaa cacggtgtat     240

ctgcaaatga acagcctgaa acctgaggaa acggccgttt attactgtgc ggcctctcat     300

agcgactgta taggttatgg gtgtcatcac gtctcgcaag actactgggg ccaggggacc     360

caggtcaccg tctcctcata atga                                            384


<210> 63
<211> 543
<212> PRT
<213> Artificial Sequence

<220> 
<223> ID1C

<400> 63
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Thr Ser Asp Val Tyr 
            20                  25                  30          
Ala Ile Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Thr Ile Asn Arg Ser Gly Ser Asp Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Glu Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Arg Ser Asp Cys Ile Gly Tyr Gly Cys Arg Arg Val Ser 
            100                 105                 110         
Gln Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala 
145                 150                 155                 160 
Gly Gly Ser Leu Arg Leu Ser Cys Val Ile Ser Gly Met Asp Phe Ser 
                165                 170                 175     
His Lys Pro Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
            180                 185                 190         
Phe Val Ala Ser Ile Thr Thr Arg Ala Ser Thr His Tyr Ala Asp Ser 
        195                 200                 205             
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
    210                 215                 220                 
Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
225                 230                 235                 240 
Cys Asn Ser Glu Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                245                 250                 255     
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         
Gly Gly Gly Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu 
        275                 280                 285             
Val Gln Ala Gly Asp Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala 
    290                 295                 300                 
Thr Leu Ser Ser Tyr Thr Ile Gly Trp Phe Arg Gln Ala Pro Glu Lys 
305                 310                 315                 320 
Glu Arg Glu Phe Val Ala Gly Ser Ser Arg Asp Gly Arg Thr Asn Tyr 
                325                 330                 335     
Tyr Ala Asn Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
            340                 345                 350         
Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
        355                 360                 365             
Ala Val Tyr Tyr Cys Ala Ala His Thr Thr Ser Gly Val Pro Val Arg 
    370                 375                 380                 
Glu Arg Ser Tyr Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
385                 390                 395                 400 
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                405                 410                 415     
Gly Gly Gly Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu 
            420                 425                 430         
Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala 
        435                 440                 445             
Thr Phe Ser Ser Tyr Tyr Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    450                 455                 460                 
Glu Arg Glu Phe Val Ala Ala Ile Asn Gly Ser Gly Gly Asn Arg Ile 
465                 470                 475                 480 
Ser Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                485                 490                 495     
Lys Asn Thr Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr 
            500                 505                 510         
Ala Val Tyr Tyr Cys Ala Ala Ser Leu Thr Tyr Tyr Gly Arg Ser Ala 
        515                 520                 525             
Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    530                 535                 540             

<210> 64
<211> 543
<212> PRT
<213> Artificial Sequence

<220> 
<223> ID3C

<400> 64
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Thr Leu Ser Ser Tyr 
            20                  25                  30          
Thr Ile Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Gly Ser Ser Arg Asp Gly Arg Thr Asn Tyr Tyr Ala Asn Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala His Thr Thr Ser Gly Val Pro Val Arg Glu Arg Ser Tyr Ala 
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
145                 150                 155                 160 
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Thr Ser Asp Val Tyr 
                165                 170                 175     
Ala Ile Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val 
            180                 185                 190         
Ala Thr Ile Asn Arg Ser Gly Ser Asp Ser Tyr Tyr Ala Asp Ser Val 
        195                 200                 205             
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
    210                 215                 220                 
Leu Gln Met Asn Ser Leu Lys Pro Glu Glu Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 
Ala Ala Ser Arg Ser Asp Cys Ile Gly Tyr Gly Cys Arg Arg Val Ser 
                245                 250                 255     
Gln Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
            260                 265                 270         
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             
Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala 
    290                 295                 300                 
Gly Gly Ser Leu Arg Leu Ser Cys Val Ile Ser Gly Met Asp Phe Ser 
305                 310                 315                 320 
His Lys Pro Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
                325                 330                 335     
Phe Val Ala Ser Ile Thr Thr Arg Ala Ser Thr His Tyr Ala Asp Ser 
            340                 345                 350         
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
        355                 360                 365             
Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
    370                 375                 380                 
Cys Asn Ser Glu Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
385                 390                 395                 400 
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                405                 410                 415     
Gly Gly Gly Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu 
            420                 425                 430         
Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala 
        435                 440                 445             
Thr Phe Ser Ser Tyr Tyr Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    450                 455                 460                 
Glu Arg Glu Phe Val Ala Ala Ile Asn Gly Ser Gly Gly Asn Arg Ile 
465                 470                 475                 480 
Ser Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                485                 490                 495     
Lys Asn Thr Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr 
            500                 505                 510         
Ala Val Tyr Tyr Cys Ala Ala Ser Leu Thr Tyr Tyr Gly Arg Ser Ala 
        515                 520                 525             
Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    530                 535                 540             

<210> 65
<211> 543
<212> PRT
<213> Artificial Sequence

<220> 
<223> ID5C

<400> 65
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Thr Leu Ser Ser Tyr 
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Gly Ser Ser Arg Asp Gly Arg Thr Asn Tyr Tyr Ala Asn Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala His Thr Thr Ser Gly Val Pro Val His Glu Arg Ser Tyr Ala 
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
145                 150                 155                 160 
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Thr Phe Ser Ser Tyr 
                165                 170                 175     
Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
            180                 185                 190         
Ala Ala Ile Asn Gly Ser Gly Gly Asn Arg Ile Ser Ala Asp Ser Val 
        195                 200                 205             
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
    210                 215                 220                 
Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 
Ala Ala Ser Leu Thr Tyr Tyr Gly His Ser Ala Arg Tyr Asp Tyr Trp 
                245                 250                 255     
Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val 
        275                 280                 285             
Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu 
    290                 295                 300                 
Arg Leu Ser Cys Ala Ala Ser Gly Ala Thr Ser Asp Val Tyr Ala Met 
305                 310                 315                 320 
Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val Ala Thr 
                325                 330                 335     
Ile Asn Arg Ser Gly Ser Asp Ser Tyr Tyr Ala Asp Ser Val Lys Gly 
            340                 345                 350         
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
        355                 360                 365             
Met Asn Ser Leu Lys Pro Glu Glu Thr Ala Val Tyr Tyr Cys Ala Ala 
    370                 375                 380                 
Ser Arg Ser Asp Cys Ile Gly Tyr Gly Cys Arg Arg Val Ser Gln Asp 
385                 390                 395                 400 
Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
                405                 410                 415     
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            420                 425                 430         
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
        435                 440                 445             
Ser Leu Arg Leu Ser Cys Val Ile Ser Gly Met Asp Phe Ser His Lys 
    450                 455                 460                 
Pro Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
465                 470                 475                 480 
Ala Ser Ile Thr Thr Arg Ala Ser Thr His Tyr Ala Asp Ser Val Lys 
                485                 490                 495     
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
            500                 505                 510         
Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
        515                 520                 525             
Ser Glu Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    530                 535                 540             

<210> 66
<211> 543
<212> PRT
<213> Artificial Sequence

<220> 
<223> ID6C

<400> 66
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Thr Ser Asp Val Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Thr Ile Asn Arg Ser Gly Ser Asp Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Glu Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Arg Ser Asp Cys Ile Gly Tyr Gly Cys Arg Arg Val Ser 
            100                 105                 110         
Gln Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala 
145                 150                 155                 160 
Gly Asp Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Thr Leu Ser 
                165                 170                 175     
Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu 
            180                 185                 190         
Phe Val Ala Gly Ser Ser Arg Asp Gly Arg Thr Asn Tyr Tyr Ala Asn 
        195                 200                 205             
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
    210                 215                 220                 
Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
225                 230                 235                 240 
Tyr Cys Ala Ala His Thr Thr Ser Gly Val Pro Val His Glu Arg Ser 
                245                 250                 255     
Tyr Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
            260                 265                 270         
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             
Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala 
    290                 295                 300                 
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Thr Phe Ser 
305                 310                 315                 320 
Ser Tyr Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
                325                 330                 335     
Phe Val Ala Ala Ile Asn Gly Ser Gly Gly Asn Arg Ile Ser Ala Asp 
            340                 345                 350         
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
        355                 360                 365             
Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
    370                 375                 380                 
Tyr Cys Ala Ala Ser Leu Thr Tyr Tyr Gly His Ser Ala Arg Tyr Asp 
385                 390                 395                 400 
Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
                405                 410                 415     
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            420                 425                 430         
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
        435                 440                 445             
Ser Leu Arg Leu Ser Cys Val Ile Ser Gly Met Asp Phe Ser His Lys 
    450                 455                 460                 
Pro Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
465                 470                 475                 480 
Ala Ser Ile Thr Thr Arg Ala Ser Thr His Tyr Ala Asp Ser Val Lys 
                485                 490                 495     
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
            500                 505                 510         
Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
        515                 520                 525             
Ser Glu Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    530                 535                 540             

<210> 67
<211> 543
<212> PRT
<213> Artificial Sequence

<220> 
<223> ID7C

<400> 67
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ile Ser Gly Met Asp Phe Ser His Lys 
            20                  25                  30          
Pro Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ser Ile Thr Thr Arg Ala Ser Thr His Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      
Ser Glu Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
            100                 105                 110         
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 
Ala Gly Asp Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Thr Leu 
145                 150                 155                 160 
Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg 
                165                 170                 175     
Glu Phe Val Ala Gly Ser Ser Arg Asp Gly Arg Thr Asn Tyr Tyr Ala 
            180                 185                 190         
Asn Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
        195                 200                 205             
Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
    210                 215                 220                 
Tyr Tyr Cys Ala Ala His Thr Thr Ser Gly Val Pro Val His Glu Arg 
225                 230                 235                 240 
Ser Tyr Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
                245                 250                 255     
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         
Gly Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln 
        275                 280                 285             
Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Thr Phe 
    290                 295                 300                 
Ser Ser Tyr Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
305                 310                 315                 320 
Glu Phe Val Ala Ala Ile Asn Gly Ser Gly Gly Asn Arg Ile Ser Ala 
                325                 330                 335     
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
            340                 345                 350         
Thr Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
        355                 360                 365             
Tyr Tyr Cys Ala Ala Ser Leu Thr Tyr Tyr Gly His Ser Ala Arg Tyr 
    370                 375                 380                 
Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
385                 390                 395                 400 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                405                 410                 415     
Ser Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
            420                 425                 430         
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Thr Ser Asp Val 
        435                 440                 445             
Tyr Ala Met Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe 
    450                 455                 460                 
Val Ala Thr Ile Asn Arg Ser Gly Ser Asp Ser Tyr Tyr Ala Asp Ser 
465                 470                 475                 480 
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
                485                 490                 495     
Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Glu Thr Ala Val Tyr Tyr 
            500                 505                 510         
Cys Ala Ala Ser Arg Ser Asp Cys Ile Gly Tyr Gly Cys Arg Arg Val 
        515                 520                 525             
Ser Gln Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    530                 535                 540             

<210> 68
<211> 543
<212> PRT
<213> Artificial Sequence

<220> 
<223> ID8C

<400> 68
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Thr Leu Ser Ser Tyr 
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Gly Ser Ser Arg Asp Gly Arg Thr Asn Tyr Tyr Ala Asn Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala His Thr Thr Ser Gly Val Pro Val His Glu Arg Ser Tyr Ala 
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
145                 150                 155                 160 
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Thr Phe Ser Ser Tyr 
                165                 170                 175     
Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
            180                 185                 190         
Ala Ala Ile Asn Gly Ser Gly Gly Asn Arg Ile Ser Ala Asp Ser Val 
        195                 200                 205             
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
    210                 215                 220                 
Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 
Ala Ala Ser Leu Thr Tyr Tyr Gly His Ser Ala His Tyr Asp Tyr Trp 
                245                 250                 255     
Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val 
        275                 280                 285             
Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu 
    290                 295                 300                 
Arg Leu Ser Cys Ala Ala Ser Gly Ala Thr Ser Asp Val Tyr Ala Met 
305                 310                 315                 320 
Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val Ala Thr 
                325                 330                 335     
Ile Asn Arg Ser Gly Ser Asp Ser Tyr Tyr Ala Asp Ser Val Lys Gly 
            340                 345                 350         
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
        355                 360                 365             
Met Asn Ser Leu Lys Pro Glu Glu Thr Ala Val Tyr Tyr Cys Ala Ala 
    370                 375                 380                 
Ser His Ser Asp Cys Ile Gly Tyr Gly Cys His His Val Ser Gln Asp 
385                 390                 395                 400 
Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
                405                 410                 415     
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            420                 425                 430         
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
        435                 440                 445             
Ser Leu Arg Leu Ser Cys Val Ile Ser Gly Met Asp Phe Ser His Lys 
    450                 455                 460                 
Pro Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
465                 470                 475                 480 
Ala Ser Ile Thr Thr Arg Ala Ser Thr His Tyr Ala Asp Ser Val Lys 
                485                 490                 495     
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
            500                 505                 510         
Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
        515                 520                 525             
Ser Glu Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    530                 535                 540             

<210> 69
<211> 543
<212> PRT
<213> Artificial Sequence

<220> 
<223> ID11C

<400> 69
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ile Ser Gly Met Asp Phe Ser His Lys 
            20                  25                  30          
Pro Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ser Ile Thr Thr Arg Ala Ser Thr His Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      
Ser Glu Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
            100                 105                 110         
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 
Ala Gly Asp Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Thr Leu 
145                 150                 155                 160 
Ser Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg 
                165                 170                 175     
Glu Phe Val Ala Gly Ser Ser Arg Asp Gly Arg Thr Asn Tyr Tyr Ala 
            180                 185                 190         
Asn Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
        195                 200                 205             
Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
    210                 215                 220                 
Tyr Tyr Cys Ala Ala His Thr Thr Ser Gly Val Pro Val His Glu Arg 
225                 230                 235                 240 
Ser Tyr Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
                245                 250                 255     
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         
Gly Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln 
        275                 280                 285             
Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Thr Phe 
    290                 295                 300                 
Ser Ser Tyr Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
305                 310                 315                 320 
Glu Phe Val Ala Ala Ile Asn Gly Ser Gly Gly Asn Arg Ile Ser Ala 
                325                 330                 335     
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
            340                 345                 350         
Thr Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
        355                 360                 365             
Tyr Tyr Cys Ala Ala Ser Leu Thr Tyr Tyr Gly His Ser Ala His Tyr 
    370                 375                 380                 
Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
385                 390                 395                 400 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                405                 410                 415     
Ser Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
            420                 425                 430         
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Thr Ser Asp Val 
        435                 440                 445             
Tyr Ala Met Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe 
    450                 455                 460                 
Val Ala Thr Ile Asn Arg Ser Gly Ser Asp Ser Tyr Tyr Ala Asp Ser 
465                 470                 475                 480 
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
                485                 490                 495     
Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Glu Thr Ala Val Tyr Tyr 
            500                 505                 510         
Cys Ala Ala Ser His Ser Asp Cys Ile Gly Tyr Gly Cys His His Val 
        515                 520                 525             
Ser Gln Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    530                 535                 540             

<210> 70
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Q31B1

<400> 70
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Leu Ser Ser Tyr 
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Gly Ser Ser Arg Asp Gly Arg Thr Asn Tyr Tyr Ala Asn Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala His Thr Thr Ser Gly Val Pro Val Arg Glu Arg Ser Tyr Ala 
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 

<210> 71
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> B10F1

<400> 71
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          
Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Asn Gly Ser Gly Gly Asn Arg Ile Ser Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Leu Thr Tyr Tyr Gly Arg Ser Ala Arg Tyr Asp Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         

<210> 72
<211> 266
<212> PRT
<213> Artificial Sequence

<220> 
<223> ID43B

<400> 72
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Thr Leu Ser Ser Tyr 
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Gly Ser Ser Arg Asp Gly Arg Thr Asn Tyr Tyr Ala Asn Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala His Thr Thr Ser Gly Val Pro Val His Glu Arg Ser Tyr Ala 
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
145                 150                 155                 160 
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Thr Phe Ser Ser Tyr 
                165                 170                 175     
Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
            180                 185                 190         
Ala Ala Ile Asn Gly Ser Gly Gly Asn Arg Ile Ser Ala Asp Ser Val 
        195                 200                 205             
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
    210                 215                 220                 
Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 
Ala Ala Ser Leu Thr Tyr Tyr Gly His Ser Ala His Tyr Asp Tyr Trp 
                245                 250                 255     
Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            260                 265     

<210> 73
<211> 266
<212> PRT
<213> Artificial Sequence

<220> 
<223> ID41B

<400> 73
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Thr Leu Ser Ser Tyr 
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Gly Ser Ser Arg Asp Gly Arg Thr Asn Tyr Tyr Ala Asn Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala His Thr Thr Ser Gly Val Pro Val His Glu Arg Ser Tyr Ala 
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
145                 150                 155                 160 
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Thr Phe Ser Ser Tyr 
                165                 170                 175     
Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
            180                 185                 190         
Ala Ala Ile Asn Gly Ser Gly Gly Asn Arg Ile Ser Ala Asp Ser Val 
        195                 200                 205             
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
    210                 215                 220                 
Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 
Ala Ala Ser Leu Thr Tyr Tyr Gly His Ser Ala Arg Tyr Asp Tyr Trp 
                245                 250                 255     
Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            260                 265     

<210> 74
<211> 2710
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of TcdA from C. difficile ribotype 087

<400> 74
Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile 
1               5                   10                  15      
Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu 
            20                  25                  30          
Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu 
        35                  40                  45              
Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr 
    50                  55                  60                  
Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys 
65                  70                  75                  80  
Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn 
                85                  90                  95      
Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu 
            100                 105                 110         
Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu 
        115                 120                 125             
Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile 
    130                 135                 140                 
Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile 
145                 150                 155                 160 
Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu 
                165                 170                 175     
Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln 
            180                 185                 190         
Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His 
        195                 200                 205             
Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg 
    210                 215                 220                 
Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg 
225                 230                 235                 240 
Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln 
                245                 250                 255     
Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg 
            260                 265                 270         
Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met 
        275                 280                 285             
Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser 
    290                 295                 300                 
Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met 
305                 310                 315                 320 
Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys 
                325                 330                 335     
Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys 
            340                 345                 350         
Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser 
        355                 360                 365             
Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln 
    370                 375                 380                 
Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu 
385                 390                 395                 400 
Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala 
                405                 410                 415     
Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp 
            420                 425                 430         
Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys 
        435                 440                 445             
Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr 
    450                 455                 460                 
Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe 
465                 470                 475                 480 
Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp 
                485                 490                 495     
Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu 
            500                 505                 510         
Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr 
        515                 520                 525             
Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu 
    530                 535                 540                 
Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr 
545                 550                 555                 560 
Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser 
                565                 570                 575     
Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser 
            580                 585                 590         
Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile 
        595                 600                 605             
Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser 
    610                 615                 620                 
Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu 
625                 630                 635                 640 
Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly 
                645                 650                 655     
Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser 
            660                 665                 670         
Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile 
        675                 680                 685             
Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser 
    690                 695                 700                 
Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser 
705                 710                 715                 720 
Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser 
                725                 730                 735     
Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly 
            740                 745                 750         
Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu 
        755                 760                 765             
Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser 
    770                 775                 780                 
Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala 
785                 790                 795                 800 
Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser 
                805                 810                 815     
Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser 
            820                 825                 830         
Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn 
        835                 840                 845             
Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu 
    850                 855                 860                 
Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu 
865                 870                 875                 880 
Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser 
                885                 890                 895     
Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr 
            900                 905                 910         
Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr 
        915                 920                 925             
Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly 
    930                 935                 940                 
Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr 
945                 950                 955                 960 
Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn 
                965                 970                 975     
Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr 
            980                 985                 990         
Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln 
        995                 1000                1005            
Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu 
    1010                1015                1020                
Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp Gly 
1025                1030                1035                1040
Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His Asp Pro 
                1045                1050                1055    
Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu Ala Ile Asn 
            1060                1065                1070        
Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile Val Gly Ile Gly 
        1075                1080                1085            
Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala Gly Ile Ser Ala Gly 
    1090                1095                1100                
Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu His Asp Lys Ala Thr 
1105                1110                1115                1120
Ser Val Val Asn Tyr Phe Asn His Leu Ser Glu Ser Lys Lys Tyr Gly 
                1125                1130                1135    
Pro Leu Lys Thr Glu Asp Asp Lys Ile Leu Val Pro Ile Asp Asp Leu 
            1140                1145                1150        
Val Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr 
        1155                1160                1165            
Cys Asn Ile Leu Ala Met Glu Gly Gly Ser Gly His Thr Val Thr Gly 
    1170                1175                1180                
Asn Ile Asp His Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro 
1185                1190                1195                1200
Ser Leu Ser Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp 
                1205                1210                1215    
Phe Ser Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe 
            1220                1225                1230        
Trp Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp 
        1235                1240                1245            
Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe 
    1250                1255                1260                
Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr Leu Lys 
1265                1270                1275                1280
Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys Asp Thr 
                1285                1290                1295    
Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile Arg Asn Lys 
            1300                1305                1310        
Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr Ser Leu Leu Leu 
        1315                1320                1325            
Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu Ser Lys Asp Asp Leu 
    1330                1335                1340                
Trp Ile Phe Asn Ile Asp Asn Glu Val Arg Glu Ile Ser Ile Glu Asn 
1345                1350                1355                1360
Gly Thr Ile Lys Lys Gly Lys Leu Ile Lys Asp Val Leu Ser Lys Ile 
                1365                1370                1375    
Asp Ile Asn Lys Asn Lys Leu Ile Ile Gly Asn Gln Thr Ile Asp Phe 
            1380                1385                1390        
Ser Gly Asp Ile Asp Asn Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu 
        1395                1400                1405            
Leu Asp Asp Lys Ile Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys 
    1410                1415                1420                
Ser Tyr Ser Leu Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn 
1425                1430                1435                1440
Leu Ser Asn Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys 
                1445                1450                1455    
Asn Ile Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly 
            1460                1465                1470        
Ala Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp 
        1475                1480                1485            
Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn 
    1490                1495                1500                
Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp Asp 
1505                1510                1515                1520
Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr Asp Lys 
                1525                1530                1535    
Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln Val Lys Val 
            1540                1545                1550        
Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser Tyr Leu Asp Phe 
        1555                1560                1565            
Val Lys Asn Ser Asp Gly His His Asn Thr Ser Asn Phe Met Asn Leu 
    1570                1575                1580                
Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu Phe Gly Phe Glu Asn Ile 
1585                1590                1595                1600
Asn Phe Val Ile Asp Lys Tyr Phe Thr Leu Val Gly Lys Thr Asn Leu 
                1605                1610                1615    
Gly Tyr Val Glu Phe Ile Cys Asp Asn Asn Lys Asn Ile Asp Ile Tyr 
            1620                1625                1630        
Phe Gly Glu Trp Lys Thr Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly 
        1635                1640                1645            
Asn Gly Arg Asn Val Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly 
    1650                1655                1660                
Glu Asp Ile Ser Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly 
1665                1670                1675                1680
Ile Asp Arg Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr 
                1685                1690                1695    
Ser Leu Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro 
            1700                1705                1710        
Glu Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile 
        1715                1720                1725            
Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser 
    1730                1735                1740                
Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile Leu 
1745                1750                1755                1760
Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser Phe Asn 
                1765                1770                1775    
Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser Leu Gly Tyr 
            1780                1785                1790        
Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn Glu Leu Asp Arg 
        1795                1800                1805            
Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys Thr Tyr Tyr Tyr Asp 
    1810                1815                1820                
Glu Asp Ser Lys Leu Val Lys Gly Leu Ile Asn Ile Asn Asn Ser Leu 
1825                1830                1835                1840
Phe Tyr Phe Asp Pro Ile Glu Phe Asn Leu Val Thr Gly Trp Gln Thr 
                1845                1850                1855    
Ile Asn Gly Lys Lys Tyr Tyr Phe Asp Ile Asn Thr Gly Ala Ala Leu 
            1860                1865                1870        
Thr Ser Tyr Lys Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Asn Asp 
        1875                1880                1885            
Gly Val Met Gln Leu Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr 
    1890                1895                1900                
Phe Ala Pro Ala Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile 
1905                1910                1915                1920
Val Tyr Gln Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe 
                1925                1930                1935    
Asp Asn Asn Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu 
            1940                1945                1950        
Lys Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln 
        1955                1960                1965            
Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile 
    1970                1975                1980                
Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp Thr 
1985                1990                1995                2000
Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly Lys His 
                2005                2010                2015    
Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val Phe Ser Thr 
            2020                2025                2030        
Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Tyr Asn Asn Asn 
        2035                2040                2045            
Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys Phe Leu Thr Leu Asn 
    2050                2055                2060                
Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser Lys Ala Val Thr Gly Leu 
2065                2070                2075                2080
Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu 
                2085                2090                2095    
Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn 
            2100                2105                2110        
Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys 
        2115                2120                2125            
Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr 
    2130                2135                2140                
Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln 
2145                2150                2155                2160
Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala 
                2165                2170                2175    
Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn 
            2180                2185                2190        
Glu Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser 
        2195                2200                2205            
Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe 
    2210                2215                2220                
Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn Asn 
2225                2230                2235                2240
Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly Tyr Ile 
                2245                2250                2255    
Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn Glu Ser Lys 
            2260                2265                2270        
Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala 
        2275                2280                2285            
Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr 
    2290                2295                2300                
Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn 
2305                2310                2315                2320
Asp Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr 
                2325                2330                2335    
Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile 
            2340                2345                2350        
Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr 
        2355                2360                2365            
Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr 
    2370                2375                2380                
Phe Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr 
2385                2390                2395                2400
Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn 
                2405                2410                2415    
Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu 
            2420                2425                2430        
Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys 
        2435                2440                2445            
Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr 
    2450                2455                2460                
Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val 
2465                2470                2475                2480
Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn 
                2485                2490                2495    
Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe 
            2500                2505                2510        
Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro 
        2515                2520                2525            
Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile 
    2530                2535                2540                
Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp 
2545                2550                2555                2560
Asn Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val 
                2565                2570                2575    
Thr Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly 
            2580                2585                2590        
Ala Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn 
        2595                2600                2605            
Gly Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr 
    2610                2615                2620                
Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile 
2625                2630                2635                2640
Arg Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe 
                2645                2650                2655    
Gly Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys 
            2660                2665                2670        
Val Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu 
        2675                2680                2685            
Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys 
    2690                2695                2700                
Ala Pro Gly Ile Tyr Gly 
2705                2710

<210> 75
<211> 2710
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of TcdA from C. difficile ribotype 078

<400> 75
Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile 
1               5                   10                  15      
Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu 
            20                  25                  30          
Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu 
        35                  40                  45              
Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn 
    50                  55                  60                  
Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys 
65                  70                  75                  80  
Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn 
                85                  90                  95      
Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu 
            100                 105                 110         
Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu 
        115                 120                 125             
Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile 
    130                 135                 140                 
Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile 
145                 150                 155                 160 
Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu 
                165                 170                 175     
Phe Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln 
            180                 185                 190         
Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His 
        195                 200                 205             
Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg 
    210                 215                 220                 
Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg 
225                 230                 235                 240 
Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln 
                245                 250                 255     
Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg 
            260                 265                 270         
Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met 
        275                 280                 285             
Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser 
    290                 295                 300                 
Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met 
305                 310                 315                 320 
Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys 
                325                 330                 335     
Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys 
            340                 345                 350         
Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser 
        355                 360                 365             
Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln 
    370                 375                 380                 
Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu 
385                 390                 395                 400 
Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala 
                405                 410                 415     
Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp 
            420                 425                 430         
Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys 
        435                 440                 445             
Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr 
    450                 455                 460                 
Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe 
465                 470                 475                 480 
Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp 
                485                 490                 495     
Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu 
            500                 505                 510         
Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr 
        515                 520                 525             
Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu 
    530                 535                 540                 
Asp Asn Glu Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr 
545                 550                 555                 560 
Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser 
                565                 570                 575     
Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser 
            580                 585                 590         
Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile 
        595                 600                 605             
Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser 
    610                 615                 620                 
Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu 
625                 630                 635                 640 
Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly 
                645                 650                 655     
Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser 
            660                 665                 670         
Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile 
        675                 680                 685             
Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser 
    690                 695                 700                 
Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser 
705                 710                 715                 720 
Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser 
                725                 730                 735     
Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly 
            740                 745                 750         
Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu 
        755                 760                 765             
Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser 
    770                 775                 780                 
Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala 
785                 790                 795                 800 
Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Thr Ser Val Ser 
                805                 810                 815     
Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser 
            820                 825                 830         
Ser Val Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn 
        835                 840                 845             
Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu 
    850                 855                 860                 
Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu 
865                 870                 875                 880 
Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser 
                885                 890                 895     
Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr 
            900                 905                 910         
Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr 
        915                 920                 925             
Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly 
    930                 935                 940                 
Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr 
945                 950                 955                 960 
Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn 
                965                 970                 975     
Lys Asp Leu Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr 
            980                 985                 990         
Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln 
        995                 1000                1005            
Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu 
    1010                1015                1020                
Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp Gly 
1025                1030                1035                1040
Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His Asp Pro 
                1045                1050                1055    
Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu Ala Ile Asn 
            1060                1065                1070        
Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile Val Gly Ile Gly 
        1075                1080                1085            
Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala Gly Ile Ser Ala Gly 
    1090                1095                1100                
Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu His Asp Lys Ala Thr 
1105                1110                1115                1120
Ser Val Val Asn Tyr Phe Asn His Leu Ser Glu Ser Lys Glu Tyr Gly 
                1125                1130                1135    
Pro Leu Lys Thr Glu Asp Asp Lys Ile Leu Val Pro Ile Asp Asp Leu 
            1140                1145                1150        
Val Ile Ser Glu Ile Asp Phe Asn Asn Asn Ala Ile Lys Leu Gly Thr 
        1155                1160                1165            
Cys Asn Ile Leu Ala Met Glu Gly Gly Ser Gly His Thr Val Thr Gly 
    1170                1175                1180                
Asn Ile Asp His Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro 
1185                1190                1195                1200
Ser Leu Ser Ile Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp 
                1205                1210                1215    
Phe Ser Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe 
            1220                1225                1230        
Trp Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn 
        1235                1240                1245            
Gly Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe 
    1250                1255                1260                
Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr Leu Lys 
1265                1270                1275                1280
Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys Asp Thr 
                1285                1290                1295    
Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile Arg Asn Lys 
            1300                1305                1310        
Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr Ser Leu Leu Leu 
        1315                1320                1325            
Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu Ser Lys Asp Asp Leu 
    1330                1335                1340                
Trp Ile Phe Asn Ile Asp Asn Glu Val Arg Glu Ile Ser Ile Glu Asn 
1345                1350                1355                1360
Gly Thr Ile Lys Lys Gly Lys Leu Ile Lys Asp Val Leu Ser Lys Ile 
                1365                1370                1375    
Asp Ile Asn Lys Asn Lys Leu Ile Ile Gly Asn Gln Thr Ile Asp Phe 
            1380                1385                1390        
Ser Gly Asp Ile Asp Asn Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu 
        1395                1400                1405            
Leu Asp Asp Lys Ile Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys 
    1410                1415                1420                
Ser Tyr Ser Leu Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn 
1425                1430                1435                1440
Leu Ser Asn Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys 
                1445                1450                1455    
Asn Ile Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly 
            1460                1465                1470        
Ala Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp 
        1475                1480                1485            
Ser Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn 
    1490                1495                1500                
Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp Asp 
1505                1510                1515                1520
Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr Asp Lys 
                1525                1530                1535    
Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln Ala Lys Val 
            1540                1545                1550        
Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser Tyr Leu Asp Phe 
        1555                1560                1565            
Val Lys Asn Ala Asp Gly His His Asn Thr Ser Asn Phe Met Asn Leu 
    1570                1575                1580                
Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu Phe Gly Phe Glu Asn Ile 
1585                1590                1595                1600
Asn Phe Val Val Asp Lys Tyr Phe Thr Leu Val Gly Lys Thr Asn Leu 
                1605                1610                1615    
Gly Tyr Val Glu Phe Ile Cys Asp Asn Asn Lys Asn Ile Asp Ile Tyr 
            1620                1625                1630        
Phe Gly Glu Trp Lys Thr Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly 
        1635                1640                1645            
Asn Gly Arg Asn Val Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly 
    1650                1655                1660                
Glu Asp Ile Ser Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly 
1665                1670                1675                1680
Ile Asp Arg Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr 
                1685                1690                1695    
Ser Leu Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro 
            1700                1705                1710        
Glu Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile 
        1715                1720                1725            
Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser 
    1730                1735                1740                
Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile Leu 
1745                1750                1755                1760
Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser Phe Asn 
                1765                1770                1775    
Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser Leu Val Tyr 
            1780                1785                1790        
Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn Glu Leu Asp Arg 
        1795                1800                1805            
Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys Thr Tyr Tyr Tyr Asp 
    1810                1815                1820                
Glu Ala Ser Lys Leu Val Lys Gly Leu Ile Asn Ile Asn Asn Ser Leu 
1825                1830                1835                1840
Phe Tyr Phe Asp Pro Ile Glu Ser Asn Leu Val Thr Gly Trp Gln Thr 
                1845                1850                1855    
Ile Asn Gly Lys Lys Tyr Tyr Phe Asp Ile Asn Thr Gly Ala Ala Leu 
            1860                1865                1870        
Thr Ser Tyr Lys Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Asn Asn 
        1875                1880                1885            
Gly Val Met Gln Leu Gly Val Phe Lys Gly Pro Asp Arg Phe Glu Tyr 
    1890                1895                1900                
Phe Ala Pro Ala Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile 
1905                1910                1915                1920
Val Tyr Gln Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe 
                1925                1930                1935    
Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu 
            1940                1945                1950        
Lys Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln 
        1955                1960                1965            
Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile 
    1970                1975                1980                
Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp Thr 
1985                1990                1995                2000
Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly Lys His 
                2005                2010                2015    
Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val Phe Ser Gly 
            2020                2025                2030        
Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Tyr Asn Asn Asn 
        2035                2040                2045            
Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys Phe Leu Thr Leu Asn 
    2050                2055                2060                
Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser Lys Ala Val Thr Gly Trp 
2065                2070                2075                2080
Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu 
                2085                2090                2095    
Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn 
            2100                2105                2110        
Thr Asn Thr Ala Glu Val Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys 
        2115                2120                2125            
Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr 
    2130                2135                2140                
Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln 
2145                2150                2155                2160
Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala 
                2165                2170                2175    
Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn 
            2180                2185                2190        
Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Ala Ser Asp Ser 
        2195                2200                2205            
Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe 
    2210                2215                2220                
Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Tyr Thr Ile Asn Asn 
2225                2230                2235                2240
Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly Tyr Ile 
                2245                2250                2255    
Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn Glu Ser Lys 
            2260                2265                2270        
Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala 
        2275                2280                2285            
Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr 
    2290                2295                2300                
Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn 
2305                2310                2315                2320
Asp Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr 
                2325                2330                2335    
Tyr Phe Asn Leu Asn Thr Ala Val Ala Val Thr Gly Trp Gln Thr Ile 
            2340                2345                2350        
Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr 
        2355                2360                2365            
Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr 
    2370                2375                2380                
Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr 
2385                2390                2395                2400
Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp 
                2405                2410                2415    
Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu 
            2420                2425                2430        
Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys 
        2435                2440                2445            
Lys Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr 
    2450                2455                2460                
Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala 
2465                2470                2475                2480
Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn 
                2485                2490                2495    
Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Asp Lys His Phe 
            2500                2505                2510        
Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro 
        2515                2520                2525            
Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile 
    2530                2535                2540                
Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp 
2545                2550                2555                2560
Asn Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val 
                2565                2570                2575    
Thr Ile Asp Gly Arg Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Ile Gly 
            2580                2585                2590        
Ala Asn Gly Tyr Lys Ile Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn 
        2595                2600                2605            
Gly Leu Pro Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr 
    2610                2615                2620                
Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile 
2625                2630                2635                2640
Arg Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe 
                2645                2650                2655    
Gly Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn 
            2660                2665                2670        
Met Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu 
        2675                2680                2685            
Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys 
    2690                2695                2700                
Ala Pro Gly Ile Tyr Gly 
2705                2710

<210> 76
<211> 2710
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of TcdA from C. difficile ribotype 027

<400> 76
Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile 
1               5                   10                  15      
Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu 
            20                  25                  30          
Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu 
        35                  40                  45              
Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn 
    50                  55                  60                  
Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys 
65                  70                  75                  80  
Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn 
                85                  90                  95      
Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu 
            100                 105                 110         
Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu 
        115                 120                 125             
Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile 
    130                 135                 140                 
Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile 
145                 150                 155                 160 
Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu 
                165                 170                 175     
Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln 
            180                 185                 190         
Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His 
        195                 200                 205             
Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg 
    210                 215                 220                 
Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg 
225                 230                 235                 240 
Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln 
                245                 250                 255     
Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg 
            260                 265                 270         
Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met 
        275                 280                 285             
Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Pro Arg Pro Ser 
    290                 295                 300                 
Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met 
305                 310                 315                 320 
Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys 
                325                 330                 335     
Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys 
            340                 345                 350         
Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser 
        355                 360                 365             
Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln 
    370                 375                 380                 
Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu 
385                 390                 395                 400 
Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala 
                405                 410                 415     
Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp 
            420                 425                 430         
Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys 
        435                 440                 445             
Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr 
    450                 455                 460                 
Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe 
465                 470                 475                 480 
Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp 
                485                 490                 495     
Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu 
            500                 505                 510         
Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr 
        515                 520                 525             
Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu 
    530                 535                 540                 
Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr 
545                 550                 555                 560 
Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser 
                565                 570                 575     
Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser 
            580                 585                 590         
Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile 
        595                 600                 605             
Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser 
    610                 615                 620                 
Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu 
625                 630                 635                 640 
Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly 
                645                 650                 655     
Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser 
            660                 665                 670         
Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile 
        675                 680                 685             
Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser 
    690                 695                 700                 
Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser 
705                 710                 715                 720 
Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser 
                725                 730                 735     
Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly 
            740                 745                 750         
Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu 
        755                 760                 765             
Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser 
    770                 775                 780                 
Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala 
785                 790                 795                 800 
Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser 
                805                 810                 815     
Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser 
            820                 825                 830         
Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn 
        835                 840                 845             
Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu 
    850                 855                 860                 
Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu 
865                 870                 875                 880 
Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser 
                885                 890                 895     
Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr 
            900                 905                 910         
Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr 
        915                 920                 925             
Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly 
    930                 935                 940                 
Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr 
945                 950                 955                 960 
Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn 
                965                 970                 975     
Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr 
            980                 985                 990         
Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln 
        995                 1000                1005            
Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu 
    1010                1015                1020                
Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp Gly 
1025                1030                1035                1040
Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His Asp Pro 
                1045                1050                1055    
Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu Ala Ile Asn 
            1060                1065                1070        
Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile Val Gly Ile Gly 
        1075                1080                1085            
Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala Gly Ile Ser Ala Gly 
    1090                1095                1100                
Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu His Asp Lys Ala Thr 
1105                1110                1115                1120
Ser Val Val Asn Tyr Phe Asn His Leu Ser Glu Ser Lys Glu Tyr Gly 
                1125                1130                1135    
Pro Leu Lys Thr Glu Asp Asp Lys Ile Leu Val Pro Ile Asp Asp Leu 
            1140                1145                1150        
Val Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr 
        1155                1160                1165            
Cys Asn Ile Leu Ala Met Glu Gly Gly Ser Gly His Thr Val Thr Gly 
    1170                1175                1180                
Asn Ile Asp His Phe Phe Ser Ser Pro Tyr Ile Ser Ser His Ile Pro 
1185                1190                1195                1200
Ser Leu Ser Val Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp 
                1205                1210                1215    
Phe Ser Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe 
            1220                1225                1230        
Trp Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn 
        1235                1240                1245            
Gly Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe 
    1250                1255                1260                
Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr Leu Lys 
1265                1270                1275                1280
Pro Val Tyr Glu Asp Thr Asn Thr Lys Ile Lys Leu Asp Lys Asp Thr 
                1285                1290                1295    
Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asp Glu Ile Arg Asn Lys 
            1300                1305                1310        
Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr Ser Leu Leu Leu 
        1315                1320                1325            
Ser Ser Tyr Pro Ile Ser Met Asn Ile Asn Leu Ser Lys Asp Asp Leu 
    1330                1335                1340                
Trp Ile Phe Asn Ile Asp Asn Glu Val Arg Glu Ile Ser Ile Glu Asn 
1345                1350                1355                1360
Gly Thr Ile Lys Lys Gly Asn Leu Ile Glu Asp Val Leu Ser Lys Ile 
                1365                1370                1375    
Asp Ile Asn Lys Asn Lys Leu Ile Ile Gly Asn Gln Thr Ile Asp Phe 
            1380                1385                1390        
Ser Gly Asp Ile Asp Asn Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu 
        1395                1400                1405            
Leu Asp Asp Lys Ile Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys 
    1410                1415                1420                
Ser Tyr Ser Leu Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn 
1425                1430                1435                1440
Leu Ser Asn Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys 
                1445                1450                1455    
Asn Ile Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly 
            1460                1465                1470        
Ala Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp 
        1475                1480                1485            
Ser Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn 
    1490                1495                1500                
Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp Asp 
1505                1510                1515                1520
Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr Asp Lys 
                1525                1530                1535    
Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln Val Lys Val 
            1540                1545                1550        
Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser Tyr Leu Asp Phe 
        1555                1560                1565            
Val Lys Asn Ser Asp Gly His His Asn Thr Ser Asn Phe Met Asn Leu 
    1570                1575                1580                
Phe Leu Asn Asn Ile Ser Phe Trp Lys Leu Phe Gly Phe Glu Asn Ile 
1585                1590                1595                1600
Asn Phe Val Ile Asp Lys Tyr Phe Thr Leu Val Gly Lys Thr Asn Leu 
                1605                1610                1615    
Gly Tyr Val Glu Phe Ile Cys Asp Asn Asn Lys Asn Ile Asp Ile Tyr 
            1620                1625                1630        
Phe Gly Glu Trp Lys Thr Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly 
        1635                1640                1645            
Asn Gly Arg Asn Val Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly 
    1650                1655                1660                
Glu Asp Ile Ser Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly 
1665                1670                1675                1680
Ile Asp Arg Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr 
                1685                1690                1695    
Ser Leu Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro 
            1700                1705                1710        
Glu Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile 
        1715                1720                1725            
Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser 
    1730                1735                1740                
Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile Leu 
1745                1750                1755                1760
Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser Phe Asn 
                1765                1770                1775    
Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser Leu Gly Tyr 
            1780                1785                1790        
Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn Glu Leu Asp Arg 
        1795                1800                1805            
Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys Thr Tyr Tyr Tyr Asp 
    1810                1815                1820                
Glu Asp Ser Lys Leu Val Lys Gly Leu Ile Asn Ile Asn Asn Ser Leu 
1825                1830                1835                1840
Phe Tyr Phe Asp Pro Ile Glu Ser Asn Leu Val Thr Gly Trp Gln Thr 
                1845                1850                1855    
Ile Asn Gly Lys Lys Tyr Tyr Phe Asp Ile Asn Thr Gly Ala Ala Ser 
            1860                1865                1870        
Thr Ser Tyr Lys Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Asn Asn 
        1875                1880                1885            
Gly Val Met Gln Leu Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr 
    1890                1895                1900                
Phe Ala Pro Ala Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile 
1905                1910                1915                1920
Val Tyr Gln Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe 
                1925                1930                1935    
Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu 
            1940                1945                1950        
Lys Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln 
        1955                1960                1965            
Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile 
    1970                1975                1980                
Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp Thr 
1985                1990                1995                2000
Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly Lys His 
                2005                2010                2015    
Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val Phe Ser Gly 
            2020                2025                2030        
Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Tyr Asn Asn Asn 
        2035                2040                2045            
Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys Phe Leu Thr Leu Asn 
    2050                2055                2060                
Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser Lys Ala Val Thr Gly Trp 
2065                2070                2075                2080
Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu 
                2085                2090                2095    
Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn 
            2100                2105                2110        
Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys 
        2115                2120                2125            
Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr 
    2130                2135                2140                
Ile Ile Asn Gly Lys Tyr Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln 
2145                2150                2155                2160
Ile Gly Val Phe Lys Val Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala 
                2165                2170                2175    
Asn Thr His Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn 
            2180                2185                2190        
Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser 
        2195                2200                2205            
Lys Ala Ile Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe 
    2210                2215                2220                
Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Cys Thr Ile Asn Asn 
2225                2230                2235                2240
Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly Tyr Ile 
                2245                2250                2255    
Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn Glu Ser Lys 
            2260                2265                2270        
Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala 
        2275                2280                2285            
Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr 
    2290                2295                2300                
Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn 
2305                2310                2315                2320
Asp Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr 
                2325                2330                2335    
Tyr Phe Asn Leu Asn Thr Ala Val Ala Val Thr Gly Trp Gln Thr Ile 
            2340                2345                2350        
Asp Gly Glu Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr 
        2355                2360                2365            
Gly Trp Gln Thr Ile Asp Gly Lys Arg Tyr Tyr Phe Asn Thr Asn Thr 
    2370                2375                2380                
Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr 
2385                2390                2395                2400
Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp 
                2405                2410                2415    
Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu 
            2420                2425                2430        
Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys 
        2435                2440                2445            
Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr 
    2450                2455                2460                
Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val 
2465                2470                2475                2480
Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn 
                2485                2490                2495    
Thr Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe 
            2500                2505                2510        
Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro 
        2515                2520                2525            
Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile 
    2530                2535                2540                
Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp 
2545                2550                2555                2560
Asn Ile Tyr Tyr Phe Gly Asn Asp Ser Lys Ala Ala Thr Gly Trp Ala 
                2565                2570                2575    
Thr Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly 
            2580                2585                2590        
Ala Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn 
        2595                2600                2605            
Gly Leu Pro Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr 
    2610                2615                2620                
Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile 
2625                2630                2635                2640
Arg Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe 
                2645                2650                2655    
Gly Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Ser Lys 
            2660                2665                2670        
Val Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu 
        2675                2680                2685            
Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys 
    2690                2695                2700                
Ala Pro Gly Ile Tyr Gly 
2705                2710

