                         SEQUENCE LISTING

<110>  Rigshospitalet
 
<120>  Cross-reactive anti-PAD antibodies

<130>  P3721PC00

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH


<220>
<221>  PEPTIDE
<222>  (1)..(123)
<223>  mSol1: Heavy chain variable region (VH) amino acid sequence

<400>  1

Leu Pro Gln Val Lys Leu Glu Gln Ser Gly Pro Gly Leu Val Gln Pro 
1               5                   10                  15      


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
            20                  25                  30          


Ser Tyr Gly Val His Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Val Ile Trp Ser Arg Gly Ser Thr Asp Tyr Asn Ala Ala 
    50                  55                  60                  


Phe Ile Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val 
65                  70                  75                  80  


Phe Phe Lys Met Asn Gly Leu Gln Ala Asn Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Arg Gly Glu Leu Gly Pro Tyr Trp Tyr Phe Asp Val 
            100                 105                 110         


Arg Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1


<220>
<221>  PEPTIDE
<222>  (1)..(8)
<223>  mSol1: Heavy chain variable region (VH) CDR1 amino acid sequence

<400>  2

Gly Phe Ser Leu Thr Ser Tyr Gly 
1               5               


<210>  3
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2


<220>
<221>  PEPTIDE
<222>  (1)..(7)
<223>  mSol1: Heavy chain variable region (VH) CDR2 amino acid sequence

<400>  3

Ile Trp Ser Arg Gly Ser Thr 
1               5           


<210>  4
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3


<220>
<221>  PEPTIDE
<222>  (1)..(15)
<223>  mSol1: Heavy chain variable region (VH) CDR3 amino acid sequence

<400>  4

Ala Arg Ile Arg Gly Glu Leu Gly Pro Tyr Trp Tyr Phe Asp Val 
1               5                   10                  15  


<210>  5
<211>  529
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH


<220>
<221>  gene
<222>  (1)..(529)
<223>  mSol1: Heavy chain variable region (VH) nucleotide sequence

<400>  5
ggaaggtgtg cacaccgctg gacagggatc cagagttcca ggtcaaggtc actggctcag       60

ggaaataacc cttgaccagg catcctagag tcaccgagga gccagttgta tctccacaca      120

caggggccag tggatagacc gatggggctg ttgttttggc tgaggagacg gtgaccgtgg      180

tccctgcgcc cctgacatcg aagtaccagt aaggtcccag ttccccccga attctggcac      240

agtaatatat ggctgtgtca ttagcttgca gaccgttcat tttaaagaaa acttggctct      300

tggaattgtc cttgctgatg ctcagtctgg atatgaaagc tgcattatag tctgtgcttc      360

cacgactcca tatcactccc agccactcca gaccctttcc tggagactgg cgaatccagt      420

gtacaccata gctagttaat gagaaaccag agactgtgca ggtgatggac aggctctgtg      480

agggctgcac taggccaggt cctgactgct ccagcttaac ctgcggaag                  529


<210>  6
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL


<220>
<221>  PEPTIDE
<222>  (1)..(113)
<223>  mSol1: Light chain variable region (VL) amino acid sequence

<400>  6

Asp Ile Val Leu Xaa Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr 
            20                  25                  30          


Gly Ser Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile Arg 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg 
                85                  90                  95      


Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Ala 
    


<210>  7
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1


<220>
<221>  PEPTIDE
<222>  (1)..(10)
<223>  mSol1: Light chain variable region (VL) CDR1 amino acid sequence

<400>  7

Glu Ser Val Glu Tyr Tyr Gly Ser Ser Leu 
1               5                   10  


<210>  8
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2


<220>
<221>  PEPTIDE
<222>  (1)..(3)
<223>  mSol1: Light chain variable region (VL) CDR2 amino acid sequence

<400>  8

Ala Ala Ser 
1           


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3


<220>
<221>  PEPTIDE
<222>  (1)..(9)
<223>  mSol1: Light chain variable region (VL) CDR3 amino acid sequence

<400>  9

Gln Gln Ser Arg Lys Val Pro Trp Thr 
1               5                   


<210>  10
<211>  365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL


<220>
<221>  gene
<222>  (1)..(365)
<223>  mSol1: Light chain variable region (VL) nucleotide sequence

<220>
<221>  misc_feature
<222>  (350)..(350)
<223>  n is a, c, g, or t

<400>  10
ggtggataca gttggtggag catcagcccg tttgatttcc agcttggtgc ctccaccgaa       60

cgtccacgga accttcctac tttgctgaca gaaatacatt gcaatatcat cctcctccac      120

aggacggatg ttgaggctga agtctgtccc agacccactg ccactaaacc tggcagggac      180

cccagattct acgttggatg cagcatagat gaggagtttg ggtggctgtc ctggtttctg      240

ttggtaccac tgcattaaac ttgagccata atattcaaca ctttcactgg ctctgcagga      300

gatggtggct ctctgcccta gagacacagc caaagaagct ggagactggn tcagcacaat      360

gtccc                                                                  365


<210>  11
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH


<220>
<221>  PEPTIDE
<222>  (1)..(118)
<223>  mSol2: Heavy chain variable region (VH) amino acid sequence

<400>  11

Glu Val Lys Xaa Xaa Glu Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Gly Asn Thr Phe 
            20                  25                  30          


Thr Lys Tyr Trp Met Gln Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu 
        35                  40                  45              


Glu Trp Ile Gly Ala Val Tyr Pro Gly Asn Gly Asp Thr Arg Tyr Thr 
    50                  55                  60                  


Gln Asp Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp Ile Ser Ser Ser 
65                  70                  75                  80  


Thr Ala Tyr Met Gln Leu Asn Asn Leu Ala Pro Glu Asp Ser Ala Val 
                85                  90                  95      


Tyr Tyr Cys Val Arg Gly Gly Ser Gly Gly Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1


<220>
<221>  PEPTIDE
<222>  (1)..(11)
<223>  mSol2: Heavy chain variable region (VH) CDR1 amino acid sequence

<400>  12

Gly Tyr Thr Gly Asn Thr Phe Thr Lys Tyr Trp 
1               5                   10      


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2


<220>
<221>  PEPTIDE
<222>  (1)..(7)
<223>  mSol2: Heavy chain variable region (VH) CDR2 amino acid sequence

<400>  13

Val Tyr Pro Gly Asn Gly Asp 
1               5           


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3


<220>
<221>  PEPTIDE
<222>  (1)..(8)
<223>  mSol2: Heavy chain variable region (VH) CDR3 amino acid sequence

<400>  14

Val Arg Gly Gly Ser Gly Gly Ser 
1               5               


<210>  15
<211>  520
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH


<220>
<221>  gene
<222>  (1)..(520)
<223>  mSol2: Heavy chain variable region (VH) nucleotide sequence

<220>
<221>  misc_feature
<222>  (502)..(502)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (504)..(504)
<223>  n is a, c, g, or t

<400>  15
ggaaggtgtg cacaccgctg gacagggatc cagagttcca ggtcactgtc actggctcag       60

ggaaatagcc cttgaccagg catcccaggg tcaccatgga gttagtttgg gcagcagatc      120

caggggccag tggatagaca gatgggggtg tcgttttggc tgcagagaca gtgaccagag      180

tcccttggcc ccaggagccg ccggaacctc ccctcacaca ataatagacc gcagagtctt      240

caggtgccaa gttgttgagt tgcatgtagg ctgtgctgga ggatatatct gcagtcaatg      300

tggccttgtc cttgaaatcc tgagtatacc tagtatcacc atttccagga taaacagccc      360

caatccattc cagaccctgt ccaggcctct gttttatcca ctgcatccag tacttggtaa      420

aggtgttgcc agtgtagcca gaggccttgc aggacaactt cactgaagcc ccaggtcttg      480

ccagctcagc cccagactcc tncngcttca cctccggaag                            520


<210>  16
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL


<220>
<221>  PEPTIDE
<222>  (1)..(113)
<223>  mSol2: Light chain variable region (VL) amino acid sequence

<400>  16

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Phe 
            20                  25                  30          


Gly Lys Ser Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Ser Ile Asp 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Asp Asp Leu Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Ala 
    


<210>  17
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1


<220>
<221>  PEPTIDE
<222>  (1)..(10)
<223>  mSol2: Light chain variable region (VL) CDR1 amino acid sequence

<400>  17

Glu Ser Val Asp Asn Phe Gly Lys Ser Phe 
1               5                   10  


<210>  18
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2


<220>
<221>  PEPTIDE
<222>  (1)..(3)
<223>  mSol2: Light chain variable region (VL) CDR2 amino acid sequence

<400>  18

Leu Ala Ser 
1           


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3


<220>
<221>  PEPTIDE
<222>  (1)..(9)
<223>  mSol2: Light chain variable region (VL) CDR3 amino acid sequence

<400>  19

Gln Gln Asn Asn Asp Asp Leu Tyr Thr 
1               5                   


<210>  20
<211>  365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL


<220>
<221>  gene
<222>  (1)..(365)
<223>  mSol2: Light chain variable region (VL) nucleotide sequence

<400>  20
ggtggataca gttggtggag catcagcccg ttttatttcc agcttggtcc cccctccgaa       60

cgtgtacaga tcgtcattat tttgctgaca gtaataggtt gcagcatcat cagcctccac      120

aggatcaatg gaaagggtga agtctgtcct agacccactg ccactgaacc tggcagggac      180

cccagattct aggttggatg caagatagat gaggagtctg ggtggttgtc ctggtttctg      240

ctggtaccag tgtagaaaac ttttgccaaa gttatcaaca ctttcactgg ctctgcagga      300

tatggtggcc ctctgcccta gagacacagc caaagaagct ggagattggg tcagcacaat      360

atccc                                                                  365


<210>  21
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH


<220>
<221>  PEPTIDE
<222>  (1)..(120)
<223>  mSol3: Heavy chain variable region (VH) amino acid sequence

<400>  21

Glu Val Gln Leu Glu Glu Ser Gly Ala Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Ile Pro Ser Asn Gly His Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Pro Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Asp Phe Phe Tyr Gly Phe Gly Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1


<220>
<221>  PEPTIDE
<222>  (1)..(9)
<223>  mSol3: Heavy chain variable region (VH) CDR1 amino acid sequence

<400>  22

Gly Tyr Thr Phe Thr Ser Tyr Trp Met 
1               5                   


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2


<220>
<221>  PEPTIDE
<222>  (1)..(8)
<223>  mSol3: Heavy chain variable region (VH) CDR2 amino acid sequence

<400>  23

Ile Ile Pro Ser Asn Gly His Thr 
1               5               


<210>  24
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3


<220>
<221>  PEPTIDE
<222>  (1)..(14)
<223>  mSol3: Heavy chain variable region (VH) CDR3 amino acid sequence

<400>  24

Ala Arg Gly Arg Asp Phe Phe Tyr Gly Phe Gly Asp Tyr Trp 
1               5                   10                  


<210>  25
<211>  526
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH


<220>
<221>  gene
<222>  (1)..(526)
<223>  mSol3: Heavy chain variable region (VH) nucleotide sequence

<400>  25
ggaaggtgtg cacaccgctg gacagggatc cagagttcca ggtcaaggtc actggctcag       60

ggaaataacc cttgaccagg catcctagag tcaccgagga gccagttgta tctccacaca      120

caggggccag tggatagacc gatggggctg ttgttttggc tgaggagact gtgagagtgg      180

tgccttggcc ccagtagtca ccgaaaccat aaaagaagtc cctccctctt gcacagtaat      240

agaccgcaga gtcctcaggt gtcaggctgc tgagttgcat gtaggctgtg ctggaggatt      300

tgtctacagt cagtgtggcc ttgctcttga acttctcatt gtagttagta tgaccattgc      360

taggaataat ctctccaatc cactcaaggc cttgtccagg cctctgcttc acccagtgca      420

tccagtagct ggtgaaggtg tagccagaag ccttgcagga cagcttcact gaagccccag      480

gcttcaccag gtcagcccca gactcctcca gctgtacctc cggaag                     526


<210>  26
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL


<220>
<221>  PEPTIDE
<222>  (1)..(115)
<223>  mSol3: Light chain variable region (VL) amino acid sequence

<400>  26

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Arg Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Arg Tyr Pro Arg Thr Phe Gly Gly Gly Thr Asn Leu Glu Ile 
            100                 105                 110         


Lys Arg Ala 
        115 


<210>  27
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1


<220>
<221>  PEPTIDE
<222>  (1)..(12)
<223>  mSol3: Light chain variable region (VL) CDR1 amino acid sequence

<400>  27

Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  28
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2


<220>
<221>  PEPTIDE
<222>  (1)..(3)
<223>  mSol3: Light chain variable region (VL) CDR2 amino acid sequence

<400>  28

Trp Ala Ser 
1           


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3


<220>
<221>  PEPTIDE
<222>  (1)..(9)
<223>  mSol3: Light chain variable region (VL) CDR3 amino acid sequence

<400>  29

Gln Gln Tyr Tyr Arg Tyr Pro Arg Thr 
1               5                   


<210>  30
<211>  371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL


<220>
<221>  gene
<222>  (1)..(371)
<223>  mSol3: Light chain variable region (VL) nucleotide sequence

<400>  30
ggtggataca gttggtggag catcagcccg tttgatttcc aggttggtgc ctccaccgaa       60

cgtccgagga tacctataat attgctgaca gtaataaact gccaggtctt cagccttcac      120

actgctgatg gtgagagtga aatctgtccc agatccactg cctgtgaagc gatcagggac      180

cccagattcc ctagtggatg cccagtaaat cagcagttta ggagactgcc ctggtttctg      240

ctggtaccag gccaagtagt tcttttgatt gctactatat aaaaggctct gactggactt      300

gcacctcata gtaaccttct ctccaactga cacagctagg gaggatggag actgggtcat      360

cacaatgtcc c                                                           371


<210>  31
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH


<220>
<221>  PEPTIDE
<222>  (1)..(116)
<223>  mSol4: Heavy chain variable region (VH) amino acid sequence

<400>  31

Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Leu Gly Gly Ser Leu Lys 
1               5                   10                  15      


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Tyr Met Ser 
            20                  25                  30          


Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Leu Val Ala Ala Ile 
        35                  40                  45              


His Ser Asp Gly Gly Asn Thr Tyr Tyr Pro Asp Thr Val Lys Gly Arg 
    50                  55                  60                  


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met 
65                  70                  75                  80  


Ser Ser Leu Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Arg His 
                85                  90                  95      


Ser Tyr Tyr Gly Ser Ser Tyr Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1


<220>
<221>  PEPTIDE
<222>  (1)..(8)
<223>  mSol4: Heavy chain variable region (VH) CDR1 amino acid sequence

<400>  32

Gly Phe Thr Phe Ser Ser Tyr Tyr 
1               5               


<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2


<220>
<221>  PEPTIDE
<222>  (1)..(8)
<223>  mSol4: Heavy chain variable region (VH) CDR2 amino acid sequence

<400>  33

Ile His Ser Asp Gly Gly Asn Thr 
1               5               


<210>  34
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH


<220>
<221>  PEPTIDE
<222>  (1)..(12)
<223>  mSol4: Heavy chain variable region (VH) CDR3 amino acid sequence

<400>  34

Ala Arg His Ser Tyr Tyr Gly Ser Ser Tyr Asp Tyr 
1               5                   10          


<210>  35
<211>  523
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH


<220>
<221>  gene
<222>  (1)..(523)
<223>  mSol4: Heavy chain variable region (VH) nucleotide sequence

<400>  35
ggaaggtgtg cacaccgctg gacagggatc cagagttcca ggtcaaggtc actggctcag       60

ggaaataacc cttgaccagg catcctagag tcaccgagga gccagttgta tctccacaca      120

caggggccag tggatagacc gatggggctg ttgttttggc tgaggagact gtgagagtgg      180

tgccttggcc ccagtagtcg taactactac cgtagtaact atgtcttgca cagtaatata      240

aggctgtgtc ctcagacttc agactgctca tttgcaggta cagggtgttc ttggcattgt      300

ctctggagat ggtgaatcgg cccttcacag tgtctggata gtaggtgtta ccaccatcac      360

tatgaatggc tgcgaccaac tccagcctct tctctggagt ctggcgaacc caagacatgt      420

aatagctact gaaagtgaat ccagaggctg cacaggagag tttcaaggac cctccaagtt      480

tcactaagtc tcccccagac tcctccagct gaacttccgg aag                        523


<210>  36
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL


<220>
<221>  PEPTIDE
<222>  (1)..(114)
<223>  mSol4: Light chain variable region (VL) amino acid sequence

<400>  36

Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Glu Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser His Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Val Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Ala 
        


<210>  37
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1


<220>
<221>  PEPTIDE
<222>  (1)..(11)
<223>  mSol4: Light chain variable region (VL) CDR1 amino acid sequence

<400>  37

Gln Ser Leu Val His Ser Asn Gly Ile Thr Tyr 
1               5                   10      


<210>  38
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2


<220>
<221>  PEPTIDE
<222>  (1)..(3)
<223>  mSol4: Light chain variable region (VL) CDR2 amino acid sequence

<400>  38

Lys Val Ser 
1           


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3


<220>
<221>  PEPTIDE
<222>  (1)..(9)
<223>  mSol4: Light chain variable region (VL) CDR3 amino acid sequence

<400>  39

Ser Gln Ser Thr His Val Pro Phe Thr 
1               5                   


<210>  40
<211>  368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL


<220>
<221>  gene
<222>  (1)..(368)
<223>  mSol4: Light chain variable region (VL): nucleotide sequence

<400>  40
ggtggataca gttggtggag catcagcccg ttttatttcc aactttgtcc ccgagccgaa       60

cgtgaatgga acatgtgtac tttgagagca gaaataaact cccagatcca cagcctccac      120

tctgctgatc ttgagtgtga aatctgtccc tgatccactg ccactgaacc tgtctgggac      180

cccagaaaat cggtgggaaa ctttgtagat caggagcttt ggagactggc ctggcttctg      240

caggtaccaa tgtaaatagg tgattccatt actgtgtaca aggctctgac tagattcgca      300

agagatggag gcttgatctc caagactgac aggcagggag agtggagact gggtgagcac      360

aatatccc                                                               368


<210>  41
<211>  665
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(665)
<223>  Human PAD2 amino acid sequence

<400>  41

Met Leu Arg Glu Arg Thr Val Arg Leu Gln Tyr Gly Ser Arg Val Glu 
1               5                   10                  15      


Ala Val Tyr Val Leu Gly Thr Tyr Leu Trp Thr Asp Val Tyr Ser Ala 
            20                  25                  30          


Ala Pro Ala Gly Ala Gln Thr Phe Ser Leu Lys His Ser Glu His Val 
        35                  40                  45              


Trp Val Glu Val Val Arg Asp Gly Glu Ala Glu Glu Val Ala Thr Asn 
    50                  55                  60                  


Gly Lys Gln Arg Trp Leu Leu Ser Pro Ser Thr Thr Leu Arg Val Thr 
65                  70                  75                  80  


Met Ser Gln Ala Ser Thr Glu Ala Ser Ser Asp Lys Val Thr Val Asn 
                85                  90                  95      


Tyr Tyr Asp Glu Glu Gly Ser Ile Pro Ile Asp Gln Ala Gly Leu Phe 
            100                 105                 110         


Leu Thr Ala Ile Glu Ile Ser Leu Asp Val Asp Ala Asp Arg Asp Gly 
        115                 120                 125             


Val Val Glu Lys Asn Asn Pro Lys Lys Ala Ser Trp Thr Trp Gly Pro 
    130                 135                 140                 


Glu Gly Gln Gly Ala Ile Leu Leu Val Asn Cys Asp Arg Glu Thr Pro 
145                 150                 155                 160 


Trp Leu Pro Lys Glu Asp Cys Arg Asp Glu Lys Val Tyr Ser Lys Glu 
                165                 170                 175     


Asp Leu Lys Asp Met Ser Gln Met Ile Leu Arg Thr Lys Gly Pro Asp 
            180                 185                 190         


Arg Leu Pro Ala Gly Tyr Glu Ile Val Leu Tyr Ile Ser Met Ser Asp 
        195                 200                 205             


Ser Asp Lys Val Gly Val Phe Tyr Val Glu Asn Pro Phe Phe Gly Gln 
    210                 215                 220                 


Arg Tyr Ile His Ile Leu Gly Arg Arg Lys Leu Tyr His Val Val Lys 
225                 230                 235                 240 


Tyr Thr Gly Gly Ser Ala Glu Leu Leu Phe Phe Val Glu Gly Leu Cys 
                245                 250                 255     


Phe Pro Asp Glu Gly Phe Ser Gly Leu Val Ser Ile His Val Ser Leu 
            260                 265                 270         


Leu Glu Tyr Met Ala Gln Asp Ile Pro Leu Thr Pro Ile Phe Thr Asp 
        275                 280                 285             


Thr Val Ile Phe Arg Ile Ala Pro Trp Ile Met Thr Pro Asn Ile Leu 
    290                 295                 300                 


Pro Pro Val Ser Val Phe Val Cys Cys Met Lys Asp Asn Tyr Leu Phe 
305                 310                 315                 320 


Leu Lys Glu Val Lys Asn Leu Val Glu Lys Thr Asn Cys Glu Leu Lys 
                325                 330                 335     


Val Cys Phe Gln Tyr Leu Asn Arg Gly Asp Arg Trp Ile Gln Asp Glu 
            340                 345                 350         


Ile Glu Phe Gly Tyr Ile Glu Ala Pro His Lys Gly Phe Pro Val Val 
        355                 360                 365             


Leu Asp Ser Pro Arg Asp Gly Asn Leu Lys Asp Phe Pro Val Lys Glu 
    370                 375                 380                 


Leu Leu Gly Pro Asp Phe Gly Tyr Val Thr Arg Glu Pro Leu Phe Glu 
385                 390                 395                 400 


Ser Val Thr Ser Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro 
                405                 410                 415     


Val Thr Val Asn Gly Lys Thr Tyr Pro Leu Gly Arg Ile Leu Ile Gly 
            420                 425                 430         


Ser Ser Phe Pro Leu Ser Gly Gly Arg Arg Met Thr Lys Val Val Arg 
        435                 440                 445             


Asp Phe Leu Lys Ala Gln Gln Val Gln Ala Pro Val Glu Leu Tyr Ser 
    450                 455                 460                 


Asp Trp Leu Thr Val Gly His Val Asp Glu Phe Met Ser Phe Val Pro 
465                 470                 475                 480 


Ile Pro Gly Thr Lys Lys Phe Leu Leu Leu Met Ala Ser Thr Ser Ala 
                485                 490                 495     


Cys Tyr Lys Leu Phe Arg Glu Lys Gln Lys Asp Gly His Gly Glu Ala 
            500                 505                 510         


Ile Met Phe Lys Gly Leu Gly Gly Met Ser Ser Lys Arg Ile Thr Ile 
        515                 520                 525             


Asn Lys Ile Leu Ser Asn Glu Ser Leu Val Gln Glu Asn Leu Tyr Phe 
    530                 535                 540                 


Gln Arg Cys Leu Asp Trp Asn Arg Asp Ile Leu Lys Lys Glu Leu Gly 
545                 550                 555                 560 


Leu Thr Glu Gln Asp Ile Ile Asp Leu Pro Ala Leu Phe Lys Met Asp 
                565                 570                 575     


Glu Asp His Arg Ala Arg Ala Phe Phe Pro Asn Met Val Asn Met Ile 
            580                 585                 590         


Val Leu Asp Lys Asp Leu Gly Ile Pro Lys Pro Phe Gly Pro Gln Val 
        595                 600                 605             


Glu Glu Glu Cys Cys Leu Glu Met His Val Arg Gly Leu Leu Glu Pro 
    610                 615                 620                 


Leu Gly Leu Glu Cys Thr Phe Ile Asp Asp Ile Ser Ala Tyr His Lys 
625                 630                 635                 640 


Phe Leu Gly Glu Val His Cys Gly Thr Asn Val Arg Arg Lys Pro Phe 
                645                 650                 655     


Thr Phe Lys Trp Trp His Met Val Pro 
            660                 665 


<210>  42
<211>  663
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(663)
<223>  Human PAD4 amino acid sequence

<400>  42

Met Ala Gln Gly Thr Leu Ile Arg Val Thr Pro Glu Gln Pro Thr His 
1               5                   10                  15      


Ala Val Cys Val Leu Gly Thr Leu Thr Gln Leu Asp Ile Cys Ser Ser 
            20                  25                  30          


Ala Pro Glu Asp Cys Thr Ser Phe Ser Ile Asn Ala Ser Pro Gly Val 
        35                  40                  45              


Val Val Asp Ile Ala His Gly Pro Pro Ala Lys Lys Lys Ser Thr Gly 
    50                  55                  60                  


Ser Ser Thr Trp Pro Leu Asp Pro Gly Val Glu Val Thr Leu Thr Met 
65                  70                  75                  80  


Lys Val Ala Ser Gly Ser Thr Gly Asp Gln Lys Val Gln Ile Ser Tyr 
                85                  90                  95      


Tyr Gly Pro Lys Thr Pro Pro Val Lys Ala Leu Leu Tyr Leu Thr Gly 
            100                 105                 110         


Val Glu Ile Ser Leu Cys Ala Asp Ile Thr Arg Thr Gly Lys Val Lys 
        115                 120                 125             


Pro Thr Arg Ala Val Lys Asp Gln Arg Thr Trp Thr Trp Gly Pro Cys 
    130                 135                 140                 


Gly Gln Gly Ala Ile Leu Leu Val Asn Cys Asp Arg Asp Asn Leu Glu 
145                 150                 155                 160 


Ser Ser Ala Met Asp Cys Glu Asp Asp Glu Val Leu Asp Ser Glu Asp 
                165                 170                 175     


Leu Gln Asp Met Ser Leu Met Thr Leu Ser Thr Lys Thr Pro Lys Asp 
            180                 185                 190         


Phe Phe Thr Asn His Thr Leu Val Leu His Val Ala Arg Ser Glu Met 
        195                 200                 205             


Asp Lys Val Arg Val Phe Gln Ala Thr Arg Gly Lys Leu Ser Ser Lys 
    210                 215                 220                 


Cys Ser Val Val Leu Gly Pro Lys Trp Pro Ser His Tyr Leu Met Val 
225                 230                 235                 240 


Pro Gly Gly Lys His Asn Met Asp Phe Tyr Val Glu Ala Leu Ala Phe 
                245                 250                 255     


Pro Asp Thr Asp Phe Pro Gly Leu Ile Thr Leu Thr Ile Ser Leu Leu 
            260                 265                 270         


Asp Thr Ser Asn Leu Glu Leu Pro Glu Ala Val Val Phe Gln Asp Ser 
        275                 280                 285             


Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Asn Thr Gln Pro 
    290                 295                 300                 


Pro Gln Glu Val Tyr Ala Cys Ser Ile Phe Glu Asn Glu Asp Phe Leu 
305                 310                 315                 320 


Lys Ser Val Thr Thr Leu Ala Met Lys Ala Lys Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Glu Glu Glu Asn Met Asp Asp Gln Trp Met Gln Asp Glu Met 
            340                 345                 350         


Glu Ile Gly Tyr Ile Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Arg Gly Leu Lys Glu Phe Pro Ile Lys Arg Val 
    370                 375                 380                 


Met Gly Pro Asp Phe Gly Tyr Val Thr Arg Gly Pro Gln Thr Gly Gly 
385                 390                 395                 400 


Ile Ser Gly Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro Val 
                405                 410                 415     


Thr Val Arg Gly Lys Glu Tyr Pro Leu Gly Arg Ile Leu Phe Gly Asp 
            420                 425                 430         


Ser Cys Tyr Pro Ser Asn Asp Ser Arg Gln Met His Gln Ala Leu Gln 
        435                 440                 445             


Asp Phe Leu Ser Ala Gln Gln Val Gln Ala Pro Val Lys Leu Tyr Ser 
    450                 455                 460                 


Asp Trp Leu Ser Val Gly His Val Asp Glu Phe Leu Ser Phe Val Pro 
465                 470                 475                 480 


Ala Pro Asp Arg Lys Gly Phe Arg Leu Leu Leu Ala Ser Pro Arg Ser 
                485                 490                 495     


Cys Tyr Lys Leu Phe Gln Glu Gln Gln Asn Glu Gly His Gly Glu Ala 
            500                 505                 510         


Leu Leu Phe Glu Gly Ile Lys Lys Lys Lys Gln Gln Lys Ile Lys Asn 
        515                 520                 525             


Ile Leu Ser Asn Lys Thr Leu Arg Glu His Asn Ser Phe Val Glu Arg 
    530                 535                 540                 


Cys Ile Asp Trp Asn Arg Glu Leu Leu Lys Arg Glu Leu Gly Leu Ala 
545                 550                 555                 560 


Glu Ser Asp Ile Ile Asp Ile Pro Gln Leu Phe Lys Leu Lys Glu Phe 
                565                 570                 575     


Ser Lys Ala Glu Ala Phe Phe Pro Asn Met Val Asn Met Leu Val Leu 
            580                 585                 590         


Gly Lys His Leu Gly Ile Pro Lys Pro Phe Gly Pro Val Ile Asn Gly 
        595                 600                 605             


Arg Cys Cys Leu Glu Glu Lys Val Cys Ser Leu Leu Glu Pro Leu Gly 
    610                 615                 620                 


Leu Gln Cys Thr Phe Ile Asn Asp Phe Phe Thr Tyr His Ile Arg His 
625                 630                 635                 640 


Gly Glu Val His Cys Gly Thr Asn Val Arg Arg Lys Pro Phe Ser Phe 
                645                 650                 655     


Lys Trp Trp Asn Met Val Pro 
            660             


<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPAD4 400-410


<220>
<221>  PEPTIDE
<222>  (1)..(11)
<223>  hPAD4 peptide 400-410

<400>  43

Gly Ile Ser Gly Leu Asp Ser Phe Gly Asn Leu 
1               5                   10      


<210>  44
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPAD4 462-477


<220>
<221>  PEPTIDE
<222>  (1)..(16)
<223>  hPAD4 peptide 462-477

<400>  44

Leu Tyr Ser Asp Trp Leu Ser Val Gly His Val Asp Glu Phe Leu Ser 
1               5                   10                  15      


<210>  45
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPAD4 569-589


<220>
<221>  PEPTIDE
<222>  (1)..(21)
<223>  hPAD4 peptide 569-589

<400>  45

Gln Leu Phe Lys Leu Lys Glu Phe Ser Lys Ala Glu Ala Phe Phe Pro 
1               5                   10                  15      


Asn Met Val Asn Met 
            20      


<210>  46
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPAD4 629-645


<220>
<221>  PEPTIDE
<222>  (1)..(17)
<223>  hPAD4 peptide 629-645

<400>  46

Phe Ile Asn Asp Phe Phe Thr Tyr His Ile Arg His Gly Glu Val His 
1               5                   10                  15      


Cys 
    


<210>  47
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPAD2 400-410


<220>
<221>  PEPTIDE
<222>  (1)..(12)
<223>  hPAD2 peptide 400-410

<400>  47

Glu Ser Val Thr Ser Leu Asp Ser Phe Gly Asn Leu 
1               5                   10          


<210>  48
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPAD2 462-477


<220>
<221>  PEPTIDE
<222>  (1)..(16)
<223>  hPAD2 peptide 462-477

<400>  48

Leu Tyr Ser Asp Trp Leu Thr Val Gly His Val Asp Glu Phe Met Ser 
1               5                   10                  15      


<210>  49
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPAD2 569-589


<220>
<221>  PEPTIDE
<222>  (1)..(21)
<223>  hPAD2 peptide 569-589

<400>  49

Ala Leu Phe Lys Met Asp Glu Asp His Arg Ala Arg Ala Phe Phe Pro 
1               5                   10                  15      


Asn Met Val Asn Met 
            20      


<210>  50
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPAD2 629-645


<220>
<221>  PEPTIDE
<222>  (1)..(17)
<223>  hPAD2 peptide 629-645

<400>  50

Phe Ile Asp Asp Ile Ser Ala Tyr His Lys Phe Leu Gly Glu Val His 
1               5                   10                  15      


Cys 
    


