                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA AS REPRESENTED BY THE 
       SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
       Pfister, Thomas D.
       Kinders, Robert J.
       Navas, Tony
 
<120>  ANTI-CD133 MONOCLONAL ANTIBODIES AND RELATED COMPOSITIONS AND 
       METHODS

<130>  1003639

<150>  US 62/138,825
<151>  2015-03-26

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  865
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15      


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30          


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45              


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60                  


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80  


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Pro Glu Thr Val 
                85                  90                  95      


Ile Leu Gly Leu Lys Ile Val Tyr Tyr Glu Ala Gly Ile Ile Leu Cys 
            100                 105                 110         


Cys Val Leu Gly Leu Leu Phe Ile Ile Leu Met Pro Leu Val Gly Tyr 
        115                 120                 125             


Phe Phe Cys Met Cys Arg Cys Cys Asn Lys Cys Gly Gly Glu Met His 
    130                 135                 140                 


Gln Arg Gln Lys Glu Asn Gly Pro Phe Leu Arg Lys Cys Phe Ala Ile 
145                 150                 155                 160 


Ser Leu Leu Val Ile Cys Ile Ile Ile Ser Ile Gly Ile Phe Tyr Gly 
                165                 170                 175     


Phe Val Ala Asn His Gln Val Arg Thr Arg Ile Lys Arg Ser Arg Lys 
            180                 185                 190         


Leu Ala Asp Ser Asn Phe Lys Asp Leu Arg Thr Leu Leu Asn Glu Thr 
        195                 200                 205             


Pro Glu Gln Ile Lys Tyr Ile Leu Ala Gln Tyr Asn Thr Thr Lys Asp 
    210                 215                 220                 


Lys Ala Phe Thr Asp Leu Asn Ser Ile Asn Ser Val Leu Gly Gly Gly 
225                 230                 235                 240 


Ile Leu Asp Arg Leu Arg Pro Asn Ile Ile Pro Val Leu Asp Glu Ile 
                245                 250                 255     


Lys Ser Met Ala Thr Ala Ile Lys Glu Thr Lys Glu Ala Leu Glu Asn 
            260                 265                 270         


Met Asn Ser Thr Leu Lys Ser Leu His Gln Gln Ser Thr Gln Leu Ser 
        275                 280                 285             


Ser Ser Leu Thr Ser Val Lys Thr Ser Leu Arg Ser Ser Leu Asn Asp 
    290                 295                 300                 


Pro Leu Cys Leu Val His Pro Ser Ser Glu Thr Cys Asn Ser Ile Arg 
305                 310                 315                 320 


Leu Ser Leu Ser Gln Leu Asn Ser Asn Pro Glu Leu Arg Gln Leu Pro 
                325                 330                 335     


Pro Val Asp Ala Glu Leu Asp Asn Val Asn Asn Val Leu Arg Thr Asp 
            340                 345                 350         


Leu Asp Gly Leu Val Gln Gln Gly Tyr Gln Ser Leu Asn Asp Ile Pro 
        355                 360                 365             


Asp Arg Val Gln Arg Gln Thr Thr Thr Val Val Ala Gly Ile Lys Arg 
    370                 375                 380                 


Val Leu Asn Ser Ile Gly Ser Asp Ile Asp Asn Val Thr Gln Arg Leu 
385                 390                 395                 400 


Pro Ile Gln Asp Ile Leu Ser Ala Phe Ser Val Tyr Val Asn Asn Thr 
                405                 410                 415     


Glu Ser Tyr Ile His Arg Asn Leu Pro Thr Leu Glu Glu Tyr Asp Ser 
            420                 425                 430         


Tyr Trp Trp Leu Gly Gly Leu Val Ile Cys Ser Leu Leu Thr Leu Ile 
        435                 440                 445             


Val Ile Phe Tyr Tyr Leu Gly Leu Leu Cys Gly Val Cys Gly Tyr Asp 
    450                 455                 460                 


Arg His Ala Thr Pro Thr Thr Arg Gly Cys Val Ser Asn Thr Gly Gly 
465                 470                 475                 480 


Val Phe Leu Met Val Gly Val Gly Leu Ser Phe Leu Phe Cys Trp Ile 
                485                 490                 495     


Leu Met Ile Ile Val Val Leu Thr Phe Val Phe Gly Ala Asn Val Glu 
            500                 505                 510         


Lys Leu Ile Cys Glu Pro Tyr Thr Ser Lys Glu Leu Phe Arg Val Leu 
        515                 520                 525             


Asp Thr Pro Tyr Leu Leu Asn Glu Asp Trp Glu Tyr Tyr Leu Ser Gly 
    530                 535                 540                 


Lys Leu Phe Asn Lys Ser Lys Met Lys Leu Thr Phe Glu Gln Val Tyr 
545                 550                 555                 560 


Ser Asp Cys Lys Lys Asn Arg Gly Thr Tyr Gly Thr Leu His Leu Gln 
                565                 570                 575     


Asn Ser Phe Asn Ile Ser Glu His Leu Asn Ile Asn Glu His Thr Gly 
            580                 585                 590         


Ser Ile Ser Ser Glu Leu Glu Ser Leu Lys Val Asn Leu Asn Ile Phe 
        595                 600                 605             


Leu Leu Gly Ala Ala Gly Arg Lys Asn Leu Gln Asp Phe Ala Ala Cys 
    610                 615                 620                 


Gly Ile Asp Arg Met Asn Tyr Asp Ser Tyr Leu Ala Gln Thr Gly Lys 
625                 630                 635                 640 


Ser Pro Ala Gly Val Asn Leu Leu Ser Phe Ala Tyr Asp Leu Glu Ala 
                645                 650                 655     


Lys Ala Asn Ser Leu Pro Pro Gly Asn Leu Arg Asn Ser Leu Lys Arg 
            660                 665                 670         


Asp Ala Gln Thr Ile Lys Thr Ile His Gln Gln Arg Val Leu Pro Ile 
        675                 680                 685             


Glu Gln Ser Leu Ser Thr Leu Tyr Gln Ser Val Lys Ile Leu Gln Arg 
    690                 695                 700                 


Thr Gly Asn Gly Leu Leu Glu Arg Val Thr Arg Ile Leu Ala Ser Leu 
705                 710                 715                 720 


Asp Phe Ala Gln Asn Phe Ile Thr Asn Asn Thr Ser Ser Val Ile Ile 
                725                 730                 735     


Glu Glu Thr Lys Lys Tyr Gly Arg Thr Ile Ile Gly Tyr Phe Glu His 
            740                 745                 750         


Tyr Leu Gln Trp Ile Glu Phe Ser Ile Ser Glu Lys Val Ala Ser Cys 
        755                 760                 765             


Lys Pro Val Ala Thr Ala Leu Asp Thr Ala Val Asp Val Phe Leu Cys 
    770                 775                 780                 


Ser Tyr Ile Ile Asp Pro Leu Asn Leu Phe Trp Phe Gly Ile Gly Lys 
785                 790                 795                 800 


Ala Thr Val Phe Leu Leu Pro Ala Leu Ile Phe Ala Val Lys Leu Ala 
                805                 810                 815     


Lys Tyr Tyr Arg Arg Met Asp Ser Glu Asp Val Tyr Asp Asp Val Glu 
            820                 825                 830         


Thr Ile Pro Met Lys Asn Met Glu Asn Gly Asn Asn Gly Tyr His Lys 
        835                 840                 845             


Asp His Val Tyr Gly Ile His Asn Pro Val Met Thr Ser Pro Ser Gln 
    850                 855                 860                 


His 
865 


<210>  2
<211>  856
<212>  PRT
<213>  Gorilla gorilla gorilla

<400>  2

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15      


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30          


Asn Tyr Glu Leu Pro Ala Thr Lys Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45              


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60                  


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Val Ile 
65                  70                  75                  80  


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Ile Val Tyr Tyr 
                85                  90                  95      


Glu Ala Gly Ile Ile Leu Cys Cys Val Leu Gly Leu Leu Phe Ile Ile 
            100                 105                 110         


Leu Met Pro Leu Val Gly Tyr Phe Phe Cys Met Cys Arg Cys Cys Asn 
        115                 120                 125             


Lys Cys Gly Gly Glu Met His Gln Arg Gln Lys Glu Asn Gly Pro Phe 
    130                 135                 140                 


Leu Arg Lys Cys Phe Ala Ile Ser Leu Leu Val Ile Cys Ile Ile Ile 
145                 150                 155                 160 


Ser Ile Gly Ile Phe Tyr Gly Phe Val Ala Asn His Gln Val Arg Thr 
                165                 170                 175     


Arg Ile Lys Arg Ser Arg Lys Leu Ala Asp Ser Asn Phe Lys Asp Leu 
            180                 185                 190         


Arg Thr Leu Leu Asn Glu Thr Pro Glu Gln Ile Lys Tyr Ile Leu Ala 
        195                 200                 205             


Gln Tyr Asn Thr Thr Lys Asp Lys Ala Phe Thr Asp Leu Asn Ser Ile 
    210                 215                 220                 


Ser Ser Val Leu Gly Gly Gly Ile Leu Asp Arg Leu Arg Pro Asn Ile 
225                 230                 235                 240 


Ile Pro Val Leu Asp Glu Ile Lys Ser Met Ala Thr Ala Ile Lys Glu 
                245                 250                 255     


Thr Lys Glu Ala Leu Glu Asn Met Asn Ser Thr Leu Lys Ser Leu His 
            260                 265                 270         


Gln Gln Ser Thr Gln Leu Ser Ser Ser Leu Thr Ser Val Lys Thr Ser 
        275                 280                 285             


Leu Arg Ser Ser Leu Asn Asp Pro Leu Cys Leu Val Arg Pro Ser Ser 
    290                 295                 300                 


Glu Thr Cys Asn Ser Ile Arg Leu Ser Leu Ser Gln Leu Asn Ser Asn 
305                 310                 315                 320 


Pro Glu Leu Arg Gln Leu Pro Pro Val Asp Ala Glu Leu Asp Asn Val 
                325                 330                 335     


Asn Asn Val Leu Arg Thr Asp Leu Asp Gly Leu Val Gln Gln Gly Tyr 
            340                 345                 350         


Gln Ser Leu Asn Asp Ile Pro Asp Arg Val Gln Arg Gln Thr Thr Thr 
        355                 360                 365             


Val Val Ala Gly Ile Lys Arg Val Leu Asn Ser Ile Gly Ser Asp Ile 
    370                 375                 380                 


Asp Asn Val Thr Gln Arg Leu Pro Ile Gln Asp Ile Leu Ser Glu Phe 
385                 390                 395                 400 


Ser Val Tyr Val Asn Asn Thr Glu Ser Tyr Ile His Arg Asn Leu Pro 
                405                 410                 415     


Thr Leu Glu Glu Tyr Asp Ser Tyr Trp Trp Leu Gly Gly Leu Val Ile 
            420                 425                 430         


Cys Ser Leu Leu Thr Leu Ile Val Ile Phe Tyr Tyr Leu Gly Leu Leu 
        435                 440                 445             


Cys Gly Val Cys Gly Tyr Asp Arg His Ala Thr Pro Thr Thr Arg Gly 
    450                 455                 460                 


Cys Val Ser Asn Thr Gly Gly Ile Phe Leu Met Val Gly Val Gly Leu 
465                 470                 475                 480 


Ser Phe Leu Phe Cys Trp Ile Leu Met Ile Ile Val Val Leu Thr Phe 
                485                 490                 495     


Val Phe Gly Ala Asn Val Glu Lys Leu Ile Cys Glu Pro Tyr Thr Ser 
            500                 505                 510         


Lys Glu Leu Phe Arg Val Leu Asp Thr Pro Tyr Leu Leu Asn Glu Asp 
        515                 520                 525             


Trp Glu Tyr Tyr Leu Ser Gly Lys Leu Phe Asn Lys Ser Lys Met Lys 
    530                 535                 540                 


Leu Thr Phe Glu Gln Val Tyr Ser Asp Cys Lys Lys Asn Arg Gly Thr 
545                 550                 555                 560 


Tyr Gly Thr Leu His Leu Gln Asn Ser Phe Asn Ile Ser Glu Arg Leu 
                565                 570                 575     


Asn Ile Asn Glu His Thr Gly Ser Ile Ser Ser Glu Leu Glu Ser Leu 
            580                 585                 590         


Lys Val Asn Leu Asn Ile Phe Leu Leu Gly Ala Ala Gly Arg Lys Asn 
        595                 600                 605             


Leu Gln Asp Phe Ala Ala Cys Gly Ile Asp Arg Met Asn Tyr Asp Ser 
    610                 615                 620                 


Tyr Leu Ala Gln Thr Gly Lys Ser Pro Ala Gly Val Asn Leu Leu Ser 
625                 630                 635                 640 


Phe Ala Tyr Asp Leu Glu Ala Lys Ala Asn Ser Leu Pro Pro Gly Asn 
                645                 650                 655     


Leu Arg Asn Ser Leu Lys Arg Asp Ala Gln Thr Ile Lys Thr Ile His 
            660                 665                 670         


Gln Gln Arg Val Leu Pro Ile Glu Gln Ser Leu Ser Thr Leu Tyr Gln 
        675                 680                 685             


Ser Val Lys Ile Leu Gln Arg Thr Gly Asn Gly Leu Leu Glu Arg Val 
    690                 695                 700                 


Thr Arg Ile Leu Ala Ser Leu Asp Phe Ala Gln Asn Phe Ile Thr Asn 
705                 710                 715                 720 


Asn Thr Ser Ser Val Ile Ile Glu Glu Thr Lys Lys Tyr Gly Arg Thr 
                725                 730                 735     


Ile Ile Gly Tyr Phe Glu His Tyr Leu Gln Trp Ile Glu Phe Ser Ile 
            740                 745                 750         


Ser Glu Lys Val Ala Ser Cys Lys Pro Val Ala Thr Ala Leu Asp Thr 
        755                 760                 765             


Ala Val Asp Val Phe Leu Cys Ser Tyr Ile Ile Asp Pro Leu Asn Leu 
    770                 775                 780                 


Phe Trp Phe Gly Ile Gly Lys Ala Thr Val Phe Leu Leu Pro Ala Leu 
785                 790                 795                 800 


Ile Phe Ala Val Lys Leu Ala Lys Tyr Tyr Arg Arg Met Asp Ser Glu 
                805                 810                 815     


Asp Val Tyr Asp Asp Val Glu Thr Ile Pro Met Lys Asn Met Glu Asn 
            820                 825                 830         


Gly Asn Asn Gly Tyr His Lys Asp His Val Tyr Gly Ile His Asn Pro 
        835                 840                 845             


Val Met Thr Ser Pro Ser Gln His 
    850                 855     


<210>  3
<211>  865
<212>  PRT
<213>  Pan troglodytes

<400>  3

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15      


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30          


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45              


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60                  


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Val Ile 
65                  70                  75                  80  


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Pro Glu Thr Val 
                85                  90                  95      


Ile Leu Gly Leu Lys Ile Val Tyr Tyr Glu Ala Gly Ile Ile Leu Cys 
            100                 105                 110         


Cys Val Leu Gly Leu Leu Phe Ile Ile Leu Met Pro Leu Val Gly Tyr 
        115                 120                 125             


Phe Phe Cys Met Cys Arg Cys Cys Asn Lys Cys Gly Gly Glu Met His 
    130                 135                 140                 


Gln Arg Gln Lys Glu Asn Gly Pro Phe Leu Arg Lys Cys Phe Ala Ile 
145                 150                 155                 160 


Ser Leu Leu Val Ile Cys Ile Ile Ile Ser Ile Gly Ile Phe Tyr Gly 
                165                 170                 175     


Phe Val Ala Asn His Gln Val Arg Thr Arg Ile Lys Arg Ser Arg Lys 
            180                 185                 190         


Leu Ala Asp Ser Asn Phe Lys Asp Leu Arg Thr Leu Leu Asn Glu Thr 
        195                 200                 205             


Pro Glu Gln Ile Lys Tyr Ile Leu Ala Gln Tyr Asn Thr Thr Lys Asp 
    210                 215                 220                 


Lys Ala Phe Thr Asp Leu Asn Ser Ile Asn Ser Val Leu Gly Gly Gly 
225                 230                 235                 240 


Ile Leu Asp Arg Leu Arg Pro Asn Ile Ile Pro Val Leu Asp Glu Ile 
                245                 250                 255     


Lys Ser Met Ala Thr Ala Ile Lys Glu Thr Lys Glu Ala Leu Glu Asn 
            260                 265                 270         


Met Asn Ser Thr Leu Lys Ser Leu His Gln Gln Ser Thr Gln Leu Ser 
        275                 280                 285             


Ser Ser Leu Thr Ser Val Lys Thr Ser Leu Arg Ser Ser Leu Asn Asp 
    290                 295                 300                 


Pro Leu Cys Leu Val Arg Pro Ser Ser Glu Ile Cys Asn Ser Ile Arg 
305                 310                 315                 320 


Leu Ser Leu Ser Gln Leu Asn Ser Asn Pro Glu Leu Arg Gln Leu Pro 
                325                 330                 335     


Pro Val Asp Ala Glu Leu Asp Asn Val Asn Asn Val Leu Arg Thr Asp 
            340                 345                 350         


Leu Asp Gly Leu Val Gln Gln Gly Tyr Gln Ser Leu Asn Asp Ile Pro 
        355                 360                 365             


Asp Arg Val Gln Arg Gln Thr Thr Thr Val Val Ala Gly Ile Lys Arg 
    370                 375                 380                 


Val Leu Asn Ser Ile Gly Ser Asp Ile Asp Asn Val Thr Gln Arg Leu 
385                 390                 395                 400 


Pro Ile Gln Asp Ile Leu Ser Glu Phe Ser Val Tyr Val Asn Asn Thr 
                405                 410                 415     


Glu Ser Tyr Ile His Arg Asn Leu Pro Thr Leu Glu Glu Tyr Asp Ser 
            420                 425                 430         


Tyr Trp Trp Leu Gly Gly Leu Val Ile Cys Ser Leu Leu Thr Leu Ile 
        435                 440                 445             


Val Ile Phe Tyr Tyr Leu Gly Leu Leu Cys Gly Val Cys Gly Tyr Asp 
    450                 455                 460                 


Arg His Ala Thr Pro Thr Thr Arg Gly Cys Val Ser Asn Thr Gly Gly 
465                 470                 475                 480 


Val Phe Leu Met Val Gly Val Gly Leu Ser Phe Leu Phe Cys Trp Ile 
                485                 490                 495     


Leu Met Ile Ile Val Val Leu Thr Phe Val Phe Gly Ala Asn Val Glu 
            500                 505                 510         


Lys Leu Ile Cys Glu Pro Tyr Thr Ser Lys Glu Leu Phe Gln Val Leu 
        515                 520                 525             


Asp Thr Pro Tyr Leu Leu Asn Glu Asp Trp Glu Tyr Tyr Leu Ser Gly 
    530                 535                 540                 


Lys Leu Phe Asn Lys Ser Lys Met Lys Leu Thr Phe Glu Gln Val Tyr 
545                 550                 555                 560 


Ser Asp Cys Lys Lys Asn Arg Gly Thr Tyr Gly Thr Leu His Leu Gln 
                565                 570                 575     


Asn Ser Phe Asn Ile Ser Glu Arg Leu Asn Ile Asn Glu His Thr Gly 
            580                 585                 590         


Ser Ile Ser Ser Glu Leu Glu Ser Leu Lys Val Asn Leu Asn Ile Phe 
        595                 600                 605             


Leu Leu Gly Ala Ala Gly Arg Lys Asn Leu Gln Asp Phe Ala Ala Cys 
    610                 615                 620                 


Gly Ile Asp Arg Met Asn Tyr Asp Ser Tyr Leu Ala Gln Thr Gly Lys 
625                 630                 635                 640 


Ser Pro Ala Gly Val Asn Leu Leu Ser Phe Ala Tyr Asp Leu Glu Ala 
                645                 650                 655     


Lys Ala Asn Ser Leu Pro Pro Gly Asn Leu Arg Asn Ser Leu Lys Arg 
            660                 665                 670         


Asp Ala Gln Thr Ile Lys Thr Ile His Gln Gln Arg Val Leu Pro Ile 
        675                 680                 685             


Glu Gln Ser Leu Ser Thr Leu Tyr Gln Ser Val Lys Ile Leu Gln Arg 
    690                 695                 700                 


Thr Gly Asn Gly Leu Leu Glu Arg Val Thr Arg Ile Leu Ala Ser Leu 
705                 710                 715                 720 


Asp Phe Ala Gln Asn Phe Ile Thr Asn Asn Thr Ser Ser Val Ile Ile 
                725                 730                 735     


Glu Glu Thr Lys Lys Tyr Gly Arg Thr Ile Ile Gly Tyr Phe Glu His 
            740                 745                 750         


Tyr Leu Gln Trp Ile Glu Phe Ser Ile Ser Glu Lys Val Ala Ser Cys 
        755                 760                 765             


Lys Pro Val Ala Thr Ala Leu Asp Thr Ala Val Asp Val Phe Leu Cys 
    770                 775                 780                 


Ser Tyr Ile Ile Asp Pro Leu Asn Leu Phe Trp Phe Gly Ile Gly Lys 
785                 790                 795                 800 


Ala Thr Val Phe Leu Leu Pro Ala Leu Ile Phe Ala Val Lys Leu Ala 
                805                 810                 815     


Lys Tyr Tyr Arg Arg Met Asp Ser Glu Asp Val Tyr Asp Asp Val Glu 
            820                 825                 830         


Thr Ile Pro Met Lys Asn Met Glu Asn Gly Asn Asn Gly Tyr His Lys 
        835                 840                 845             


Asp His Val Tyr Gly Ile His Asn Pro Val Met Thr Ser Pro Ser Gln 
    850                 855                 860                 


His 
865 


<210>  4
<211>  839
<212>  PRT
<213>  Canis lupus familiaris

<400>  4

Met Ala Leu Leu Leu Gly Phe Leu Leu Leu Leu Glu Leu Cys Trp Asp 
1               5                   10                  15      


Thr Ser Ala Leu Gly Pro Leu Ser Ser Thr Lys Gly Ser Asp Gly Leu 
            20                  25                  30          


Glu Phe Glu Leu Pro Ala Thr Asn Tyr Glu Thr Lys Asp Ser Asn Gln 
        35                  40                  45              


Ala Gly Pro Ile Ser Val Leu Phe Gln Ile Val Gln Val Phe Leu Gln 
    50                  55                  60                  


Val Val Gln Pro His Pro Phe Pro Glu Asp Ile Leu Arg Lys Ile Leu 
65                  70                  75                  80  


Gln Lys Lys Phe Asp Phe Ser Thr Asp Tyr Asp Lys Ile Ile Tyr Tyr 
                85                  90                  95      


Glu Ile Gly Ile Ile Ile Cys Ala Val Leu Gly Leu Leu Phe Val Ile 
            100                 105                 110         


Leu Met Pro Leu Val Gly Phe Cys Leu Gly Leu Cys Arg Cys Cys Asn 
        115                 120                 125             


Lys Cys Gly Gly Glu Met His Gln Arg Gln Lys Lys Asn Gly Ala Phe 
    130                 135                 140                 


Leu Arg Lys Tyr Phe Thr Val Ser Leu Leu Val Ile Cys Ile Phe Ile 
145                 150                 155                 160 


Ser Val Gly Ile Ile Tyr Gly Phe Val Ala Asn His His Leu Arg Thr 
                165                 170                 175     


Arg Ile Glu Lys Thr Arg Lys Leu Ala Glu Ser Asn Leu Lys Asp Leu 
            180                 185                 190         


Arg Thr Leu Leu Ile Gly Thr Pro Ala Gln Ile Asn Tyr Val Leu Ser 
        195                 200                 205             


Gln Tyr Ala Ser Thr Lys Glu Lys Ala Phe Ser Asp Leu Asp Asn Ile 
    210                 215                 220                 


Lys Ser Leu Leu Gly Gly Gly Ile His Asp Gln Leu Arg Pro Lys Val 
225                 230                 235                 240 


Ile Pro Val Leu Asp Asp Ile Lys Ala Met Ala Glu Ala Ile Lys Glu 
                245                 250                 255     


Thr Arg Glu Ala Leu Leu Asn Val Asn Asn Thr Leu Lys Glu Leu Lys 
            260                 265                 270         


Met Ser Thr Ala Gln Leu Asn Thr Ser Leu Ser Asp Val Lys Arg Asn 
        275                 280                 285             


Leu Glu Gln Ser Leu Asn Asp Pro Met Cys Ser Val Pro Pro Val Ala 
    290                 295                 300                 


Thr Thr Cys Asn Asn Ile Arg Met Ser Leu Gly Gln Leu Asp Asp Asn 
305                 310                 315                 320 


Thr Asn Leu Gly Gln Leu Pro Ser Leu Asp Lys Gln Ile Asp Asn Ile 
                325                 330                 335     


Asn Asn Val Leu Gln Thr Asp Leu Ser Ser Leu Val Gln Lys Gly Tyr 
            340                 345                 350         


Lys Ser Phe Asn Asp Ile Pro Glu Met Val Gln Asn Gln Thr Thr Asp 
        355                 360                 365             


Ile Val Ser Asp Val Lys Arg Thr Leu Asn Ser Leu Gly Ser Asp Ile 
    370                 375                 380                 


Glu Asn Met Ser Glu Gln Ile Pro Ile Gln Asp Lys Leu Ser Asp Phe 
385                 390                 395                 400 


Ile Gly Tyr Ile Asn Asp Thr Glu Thr Tyr Ile His Arg Asn Leu Pro 
                405                 410                 415     


Thr Leu Glu Glu Tyr Asp Ser Tyr Arg Trp Leu Gly Gly Leu Ile Val 
            420                 425                 430         


Cys Cys Leu Leu Thr Leu Ile Val Val Phe Tyr Tyr Leu Gly Leu Met 
        435                 440                 445             


Cys Gly Thr Phe Gly Tyr Asp Arg His Ala Thr Pro Thr Arg Arg Gly 
    450                 455                 460                 


Cys Val Ser Asn Thr Gly Gly Ile Phe Leu Met Val Gly Val Gly Ile 
465                 470                 475                 480 


Ser Phe Leu Phe Cys Trp Ile Leu Met Thr Ile Val Val Leu Thr Phe 
                485                 490                 495     


Val Ile Gly Gly Asn Met Glu Lys Leu Val Cys Glu Pro Tyr Gln Asn 
            500                 505                 510         


Arg Lys Leu Phe Gln Ile Leu Asp Thr Pro Tyr Leu Leu Asn Glu Asn 
        515                 520                 525             


Trp Lys Tyr Tyr Leu Ser Gly Met Val Leu Asn Lys Pro Asp Ile Asn 
    530                 535                 540                 


Leu Thr Phe Glu Gln Val Tyr Ser Asp Cys Lys Glu Asn Lys Gly Ile 
545                 550                 555                 560 


Tyr Ser Thr Leu Lys Leu Glu Asn Thr Tyr Asn Ile Ser Glu His Leu 
                565                 570                 575     


Asn Ile Gln Glu His Ala Arg Asn Leu Ser Asn Asp Phe Lys Asn Met 
            580                 585                 590         


Asn Val Asn Ile Asp Asn Ile Val Leu Leu Asp Ala Ala Gly Arg Lys 
        595                 600                 605             


Asn Leu Met Asp Phe Ser Ser Ser Gly Val Asp Thr Ile Asp Tyr Asn 
    610                 615                 620                 


Val Tyr Leu Ala Glu Met Gly Lys Thr Pro Thr Lys Val Asn Leu Leu 
625                 630                 635                 640 


Ser Phe Ala Asp Asp Leu Asp Thr Lys Ala Asn Asn Leu Pro Gln Gly 
                645                 650                 655     


Ser Leu Lys Gln Ser Leu Lys Asn Asn Val Gln Asn Leu Lys Thr Ile 
            660                 665                 670         


His His Gly Gln Val Met Pro Leu Glu Gln Ser Met Ser Thr Ile Asn 
        675                 680                 685             


Gln Ser Ile Lys Glu Leu Gln His Lys Ser Ser Gly Leu Arg Val Lys 
    690                 695                 700                 


Val Ala Asn Ile Leu Ser Ser Leu Asp Ser Ala Gln Asp Phe Leu Gln 
705                 710                 715                 720 


Thr Arg Ile Ser Ser Val Ile Val Lys Glu Ser Ser Lys Tyr Gly Asn 
                725                 730                 735     


Met Ile Ile Gly Tyr Phe Glu His Tyr Leu Gln Trp Val Lys Ile Ser 
            740                 745                 750         


Ile Thr Glu Gln Ile Ala Ala Cys Lys Pro Val Ala Thr Ala Leu Asp 
        755                 760                 765             


Ser Ala Val Asp Val Phe Leu Cys Ser Tyr Ile Ile Asp Pro Met Asn 
    770                 775                 780                 


Leu Phe Trp Phe Gly Ile Gly Lys Ala Thr Ile Phe Leu Leu Pro Ala 
785                 790                 795                 800 


Ile Ile Phe Ala Val Lys Leu Ala Lys Tyr Tyr Arg Arg Met Asp Ser 
                805                 810                 815     


Glu Asp Val Tyr Asp Asp Met Glu Asn Gly Asn Ile Gly Phe His Arg 
            820                 825                 830         


His His Ser Thr Gln Thr Val 
        835                 


<210>  5
<211>  842
<212>  PRT
<213>  Mus musculus

<400>  5

Met Ala Leu Val Phe Ser Ala Leu Leu Leu Leu Gly Leu Cys Gly Lys 
1               5                   10                  15      


Ile Ser Ser Glu Gly Gln Pro Ala Phe His Asn Thr Pro Gly Ala Met 
            20                  25                  30          


Asn Tyr Glu Leu Pro Thr Thr Lys Tyr Glu Thr Gln Asp Thr Phe Asn 
        35                  40                  45              


Ala Gly Ile Val Gly Pro Leu Tyr Lys Met Val His Ile Phe Leu Asn 
    50                  55                  60                  


Val Val Gln Pro Asn Asp Phe Pro Leu Asp Leu Ile Lys Lys Leu Ile 
65                  70                  75                  80  


Gln Asn Lys Asn Phe Asp Ile Ser Val Asp Ser Lys Glu Pro Glu Ile 
                85                  90                  95      


Ile Val Leu Ala Leu Lys Ile Ala Leu Tyr Glu Ile Gly Val Leu Ile 
            100                 105                 110         


Cys Ala Ile Leu Gly Leu Leu Phe Ile Ile Leu Met Pro Leu Val Gly 
        115                 120                 125             


Cys Phe Phe Cys Met Cys Arg Cys Cys Asn Lys Cys Gly Gly Glu Met 
    130                 135                 140                 


His Gln Arg Gln Lys Gln Asn Ala Pro Cys Arg Arg Lys Cys Leu Gly 
145                 150                 155                 160 


Leu Ser Leu Leu Val Ile Cys Leu Leu Met Ser Leu Gly Ile Ile Tyr 
                165                 170                 175     


Gly Phe Val Ala Asn Gln Gln Thr Arg Thr Arg Ile Lys Gly Thr Gln 
            180                 185                 190         


Lys Leu Ala Lys Ser Asn Phe Arg Asp Phe Gln Thr Leu Leu Thr Glu 
        195                 200                 205             


Thr Pro Lys Gln Ile Asp Tyr Val Val Glu Gln Tyr Thr Asn Thr Lys 
    210                 215                 220                 


Asn Lys Ala Phe Ser Asp Leu Asp Gly Ile Gly Ser Val Leu Gly Gly 
225                 230                 235                 240 


Arg Ile Lys Asp Gln Leu Lys Pro Lys Val Thr Pro Val Leu Glu Glu 
                245                 250                 255     


Ile Lys Ala Met Ala Thr Ala Ile Lys Gln Thr Lys Asp Ala Leu Gln 
            260                 265                 270         


Asn Met Ser Ser Ser Leu Lys Ser Leu Gln Asp Ala Ala Thr Gln Leu 
        275                 280                 285             


Asn Thr Asn Leu Ser Ser Val Arg Asn Ser Ile Glu Asn Ser Leu Ser 
    290                 295                 300                 


Ser Ser Asp Cys Thr Ser Asp Pro Ala Ser Lys Ile Cys Asp Ser Ile 
305                 310                 315                 320 


Arg Pro Ser Leu Ser Ser Leu Gly Ser Ser Leu Asn Ser Ser Gln Leu 
                325                 330                 335     


Pro Ser Val Asp Arg Glu Leu Asn Thr Val Thr Glu Val Asp Lys Thr 
            340                 345                 350         


Asp Leu Glu Ser Leu Val Lys Arg Gly Tyr Thr Thr Ile Asp Glu Ile 
        355                 360                 365             


Pro Asn Thr Ile Gln Asn Gln Thr Val Asp Val Ile Lys Asp Val Lys 
    370                 375                 380                 


Asn Thr Leu Asp Ser Ile Ser Ser Asn Ile Lys Asp Met Ser Gln Ser 
385                 390                 395                 400 


Ile Pro Ile Glu Asp Met Leu Leu Gln Val Ser His Tyr Leu Asn Asn 
                405                 410                 415     


Ser Asn Arg Tyr Leu Asn Gln Glu Leu Pro Lys Leu Glu Glu Tyr Asp 
            420                 425                 430         


Ser Tyr Trp Trp Leu Gly Gly Leu Ile Val Cys Phe Leu Leu Thr Leu 
        435                 440                 445             


Ile Val Thr Phe Phe Phe Leu Gly Leu Leu Cys Gly Val Phe Gly Tyr 
    450                 455                 460                 


Asp Lys His Ala Thr Pro Thr Arg Arg Gly Cys Val Ser Asn Thr Gly 
465                 470                 475                 480 


Gly Ile Phe Leu Met Ala Gly Val Gly Phe Gly Phe Leu Phe Cys Trp 
                485                 490                 495     


Ile Leu Met Ile Leu Val Val Leu Thr Phe Val Val Gly Ala Asn Val 
            500                 505                 510         


Glu Lys Leu Leu Cys Glu Pro Tyr Glu Asn Lys Lys Leu Leu Gln Val 
        515                 520                 525             


Leu Asp Thr Pro Tyr Leu Leu Lys Glu Gln Trp Gln Phe Tyr Leu Ser 
    530                 535                 540                 


Gly Met Leu Phe Asn Asn Pro Asp Ile Asn Met Thr Phe Glu Gln Val 
545                 550                 555                 560 


Tyr Arg Asp Cys Lys Arg Gly Arg Gly Ile Tyr Ala Ala Phe Gln Leu 
                565                 570                 575     


Glu Asn Val Val Asn Val Ser Asp His Phe Asn Ile Asp Gln Ile Ser 
            580                 585                 590         


Glu Asn Ile Asn Thr Glu Leu Glu Asn Leu Asn Val Asn Ile Asp Ser 
        595                 600                 605             


Ile Glu Leu Leu Asp Asn Thr Gly Arg Lys Ser Leu Glu Asp Phe Ala 
    610                 615                 620                 


His Ser Gly Ile Asp Thr Ile Asp Tyr Ser Thr Tyr Leu Lys Glu Thr 
625                 630                 635                 640 


Glu Lys Ser Pro Thr Glu Val Asn Leu Leu Thr Phe Ala Ser Thr Leu 
                645                 650                 655     


Glu Ala Lys Ala Asn Gln Leu Pro Glu Gly Lys Leu Lys Gln Ala Phe 
            660                 665                 670         


Leu Leu Asp Val Gln Asn Ile Arg Ala Ile His Gln His Leu Leu Pro 
        675                 680                 685             


Pro Val Gln Gln Ser Leu Lys Phe Val Arg Val Arg Asn Thr Leu Arg 
    690                 695                 700                 


Gln Ser Val Trp Thr Leu Gln Gln Thr Ser Asn Lys Leu Pro Glu Lys 
705                 710                 715                 720 


Val Lys Lys Ile Leu Ala Ser Leu Asp Ser Val Gln His Phe Leu Thr 
                725                 730                 735     


Asn Asn Val Ser Leu Ile Val Ile Gly Glu Thr Lys Lys Phe Gly Lys 
            740                 745                 750         


Thr Ile Leu Gly Tyr Phe Glu His Tyr Leu His Trp Val Phe Tyr Ala 
        755                 760                 765             


Ile Thr Glu Lys Met Thr Ser Cys Lys Pro Met Ala Thr Ala Met Asp 
    770                 775                 780                 


Ser Ala Val Asn Gly Ile Leu Cys Gly Tyr Val Ala Asp Pro Leu Asn 
785                 790                 795                 800 


Leu Phe Trp Phe Gly Ile Gly Lys Ala Thr Val Leu Leu Leu Pro Ala 
                805                 810                 815     


Val Ile Ile Ala Ile Lys Leu Ala Lys Tyr Tyr Arg Arg Met Asp Ser 
            820                 825                 830         


Glu Asp Val Tyr Asp Asp Pro Ser Arg Tyr 
        835                 840         


<210>  6
<211>  857
<212>  PRT
<213>  Rattus norvegicus

<400>  6

Met Ala Leu Val Phe Ser Val Leu Leu Leu Leu Gly Leu Cys Gly Lys 
1               5                   10                  15      


Met Ala Ser Gly Gly Gln Pro Ala Phe Asp Asn Thr Pro Gly Ala Leu 
            20                  25                  30          


Asn Tyr Glu Leu Pro Thr Thr Glu Tyr Glu Thr Gln Asp Thr Phe Asn 
        35                  40                  45              


Ala Gly Ile Ile Asp Pro Leu Tyr Gln Met Val His Ile Phe Leu Asn 
    50                  55                  60                  


Val Val Gln Pro Asn Asp Phe Pro Gln Asp Leu Val Lys Lys Leu Ile 
65                  70                  75                  80  


Gln Lys Arg Phe Asp Ile Ser Val Asp Thr Lys Glu Val Ala Ile Tyr 
                85                  90                  95      


Glu Ile Gly Val Leu Ile Cys Val Ile Leu Gly Leu Leu Phe Ile Phe 
            100                 105                 110         


Leu Met Pro Leu Val Gly Phe Phe Phe Cys Met Cys Arg Cys Cys Asn 
        115                 120                 125             


Lys Cys Gly Gly Glu Met His Gln Arg Gln Lys Gln Asn Glu Ser Cys 
    130                 135                 140                 


Arg Arg Lys Cys Leu Ala Ile Ser Leu Leu Leu Ile Cys Leu Leu Met 
145                 150                 155                 160 


Ser Leu Gly Ile Ala Phe Gly Phe Val Ala Asn Gln Gln Thr Arg Thr 
                165                 170                 175     


Arg Ile Gln Arg Thr Gln Lys Leu Ala Glu Ser Asn Tyr Arg Asp Leu 
            180                 185                 190         


Arg Ala Leu Leu Thr Glu Ala Pro Lys Gln Ile Asp Tyr Ile Leu Gly 
        195                 200                 205             


Gln Tyr Asn Thr Thr Lys Asn Lys Ala Phe Ser Asp Leu Asp Ser Ile 
    210                 215                 220                 


Asp Ser Val Leu Gly Gly Arg Ile Lys Gly Gln Leu Lys Pro Lys Val 
225                 230                 235                 240 


Thr Pro Val Leu Glu Glu Ile Lys Ala Met Ala Thr Ala Ile Arg Gln 
                245                 250                 255     


Thr Lys Asp Ala Leu Gln Asn Met Ser Ser Ser Leu Lys Ser Leu Arg 
            260                 265                 270         


Asp Ala Ser Thr Gln Leu Ser Thr Asn Leu Thr Ser Val Arg Asn Ser 
        275                 280                 285             


Ile Glu Asn Ser Leu Asn Ser Asn Asp Cys Ala Ser Asp Pro Ala Ser 
    290                 295                 300                 


Lys Ile Cys Asp Ser Leu Arg Pro Gln Leu Ser Asn Leu Gly Ser Asn 
305                 310                 315                 320 


His Asn Gly Ser Gln Leu Pro Ser Val Asp Arg Glu Leu Asn Thr Val 
                325                 330                 335     


Asn Asp Val Asp Arg Thr Asp Leu Glu Ser Leu Val Lys Arg Gly Tyr 
            340                 345                 350         


Met Ser Ile Asp Glu Ile Pro Asn Met Ile Gln Asn Gln Thr Gly Asp 
        355                 360                 365             


Val Ile Lys Asp Val Lys Lys Thr Leu Asp Ser Val Ser Ser Lys Val 
    370                 375                 380                 


Lys Asn Met Ser Gln Ser Ile Pro Val Glu Glu Val Leu Leu Gln Phe 
385                 390                 395                 400 


Ser His Tyr Leu Asn Asp Ser Asn Arg Tyr Ile His Glu Ser Leu Pro 
                405                 410                 415     


Arg Val Glu Glu Tyr Asp Ser Tyr Trp Trp Leu Gly Gly Leu Ile Val 
            420                 425                 430         


Cys Phe Leu Leu Thr Leu Ile Val Thr Phe Phe Tyr Leu Gly Leu Leu 
        435                 440                 445             


Cys Gly Val Phe Gly Tyr Asp Lys Arg Ala Thr Pro Thr Arg Arg Gly 
    450                 455                 460                 


Cys Val Ser Asn Thr Gly Gly Ile Phe Leu Met Ala Gly Val Gly Phe 
465                 470                 475                 480 


Ser Phe Leu Phe Cys Trp Ile Leu Met Ile Leu Val Val Leu Thr Phe 
                485                 490                 495     


Val Val Gly Ala Asn Val Glu Lys Leu Leu Cys Glu Pro Tyr Glu Asn 
            500                 505                 510         


Lys Lys Leu Leu Gln Val Leu Asp Thr Pro Tyr Leu Leu Asn Asp Gln 
        515                 520                 525             


Trp Gln Phe Tyr Leu Ser Gly Ile Leu Leu Lys Asn Pro Asp Ile Asn 
    530                 535                 540                 


Met Thr Phe Glu Gln Val Tyr Arg Asp Cys Lys Arg Gly Arg Gly Val 
545                 550                 555                 560 


Tyr Ala Thr Phe Gln Leu Glu Asn Val Phe Asn Ile Thr Glu Asn Phe 
                565                 570                 575     


Asn Ile Glu Arg Leu Ser Glu Asp Ile Val Lys Glu Leu Glu Lys Leu 
            580                 585                 590         


Asn Val Asn Ile Asp Ser Ile Glu Leu Leu Asp Lys Thr Gly Arg Lys 
        595                 600                 605             


Ser Leu Glu Asp Phe Ala Gln Ser Gly Ile Asp Arg Ile Asn Tyr Ser 
    610                 615                 620                 


Met Tyr Leu Gln Glu Ala Glu Lys Pro Pro Thr Lys Val Asp Leu Leu 
625                 630                 635                 640 


Thr Phe Ala Ser Phe Leu Glu Thr Glu Ala Asn Gln Leu Pro Asp Gly 
                645                 650                 655     


Asn Leu Lys Gln Ala Phe Leu Met Asp Ala Gln Asn Ile Arg Ala Ile 
            660                 665                 670         


His Gln Gln His Val Pro Pro Val Gln Gln Ser Leu Asn Ser Leu Lys 
        675                 680                 685             


Gln Ser Val Trp Ala Leu Lys Gln Thr Ser Ser Lys Leu Pro Glu Glu 
    690                 695                 700                 


Val Lys Lys Val Leu Ala Ser Leu Asp Ser Ala Gln His Phe Leu Thr 
705                 710                 715                 720 


Ser Asn Leu Ser Ser Ile Val Ile Gly Glu Thr Lys Lys Phe Gly Arg 
                725                 730                 735     


Thr Ile Ile Gly Tyr Phe Glu His Tyr Leu Gln Trp Val Leu Tyr Ala 
            740                 745                 750         


Ile Thr Glu Lys Met Thr Ser Cys Lys Pro Met Ile Thr Ala Met Asp 
        755                 760                 765             


Ser Ala Val Asn Gly Ile Leu Cys Ser Tyr Val Ala Asp Pro Leu Asn 
    770                 775                 780                 


Leu Phe Trp Phe Gly Ile Gly Lys Ala Thr Met Leu Leu Leu Pro Ala 
785                 790                 795                 800 


Val Ile Ile Ala Ile Lys Leu Ala Lys Tyr Tyr Arg Arg Met Asp Ser 
                805                 810                 815     


Glu Asp Val Tyr Asp Asp Val Glu Thr Val Pro Met Lys Asn Leu Glu 
            820                 825                 830         


Asn Gly Ser Asn Gly Tyr His Lys Asp His Leu Tyr Gly Val His Asn 
        835                 840                 845             


Pro Val Met Thr Ser Pro Ser Arg Tyr 
    850                 855         


<210>  7
<211>  852
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15      


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30          


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45              


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60                  


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80  


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Pro Glu Thr Val 
                85                  90                  95      


Ile Leu Gly Leu Lys Ile Val Tyr Tyr Glu Ala Gly Ile Ile Leu Cys 
            100                 105                 110         


Cys Val Leu Gly Leu Leu Phe Ile Ile Leu Met Pro Leu Val Gly Tyr 
        115                 120                 125             


Phe Phe Cys Met Cys Arg Cys Cys Asn Lys Cys Gly Gly Glu Met His 
    130                 135                 140                 


Gln Arg Gln Lys Glu Asn Gly Pro Phe Leu Arg Lys Cys Phe Ala Ile 
145                 150                 155                 160 


Ser Leu Leu Val Ile Cys Ile Ile Ile Ser Ile Gly Ile Phe Tyr Gly 
                165                 170                 175     


Phe Val Ala Asn His Gln Val Arg Thr Arg Ile Lys Arg Ser Arg Lys 
            180                 185                 190         


Leu Ala Asp Ser Asn Phe Lys Asp Leu Arg Thr Leu Leu Asn Glu Thr 
        195                 200                 205             


Pro Glu Gln Ile Lys Tyr Ile Leu Ala Gln Tyr Asn Thr Thr Lys Asp 
    210                 215                 220                 


Lys Ala Phe Thr Asp Leu Asn Ser Ile Asn Ser Val Leu Gly Gly Gly 
225                 230                 235                 240 


Ile Leu Asp Arg Leu Arg Pro Asn Ile Ile Pro Val Leu Asp Glu Ile 
                245                 250                 255     


Lys Ser Met Ala Thr Ala Ile Lys Glu Thr Lys Glu Ala Leu Glu Asn 
            260                 265                 270         


Met Asn Ser Thr Leu Lys Ser Leu His Gln Gln Ser Thr Gln Leu Ser 
        275                 280                 285             


Ser Ser Leu Thr Ser Val Lys Thr Ser Leu Arg Ser Ser Leu Asn Asp 
    290                 295                 300                 


Pro Leu Cys Leu Val His Pro Ser Ser Glu Thr Cys Asn Ser Ile Arg 
305                 310                 315                 320 


Leu Ser Leu Ser Gln Leu Asn Ser Asn Pro Glu Leu Arg Gln Leu Pro 
                325                 330                 335     


Pro Val Asp Ala Glu Leu Asp Asn Val Asn Asn Val Leu Arg Thr Asp 
            340                 345                 350         


Leu Asp Gly Leu Val Gln Gln Gly Tyr Gln Ser Leu Asn Asp Ile Pro 
        355                 360                 365             


Asp Arg Val Gln Arg Gln Thr Thr Thr Val Val Ala Gly Ile Lys Arg 
    370                 375                 380                 


Val Leu Asn Ser Ile Gly Ser Asp Ile Asp Asn Val Thr Gln Arg Leu 
385                 390                 395                 400 


Pro Ile Gln Asp Ile Leu Ser Ala Phe Ser Val Tyr Val Asn Asn Thr 
                405                 410                 415     


Glu Ser Tyr Ile His Arg Asn Leu Pro Thr Leu Glu Glu Tyr Asp Ser 
            420                 425                 430         


Tyr Trp Trp Leu Gly Gly Leu Val Ile Cys Ser Leu Leu Thr Leu Ile 
        435                 440                 445             


Val Ile Phe Tyr Tyr Leu Gly Leu Leu Cys Gly Val Cys Gly Tyr Asp 
    450                 455                 460                 


Arg His Ala Thr Pro Thr Thr Arg Gly Cys Val Ser Asn Thr Gly Gly 
465                 470                 475                 480 


Val Phe Leu Met Val Gly Val Gly Leu Ser Phe Leu Phe Cys Trp Ile 
                485                 490                 495     


Leu Met Ile Ile Val Val Leu Thr Phe Val Phe Gly Ala Asn Val Glu 
            500                 505                 510         


Lys Leu Ile Cys Glu Pro Tyr Thr Ser Lys Glu Leu Phe Arg Val Leu 
        515                 520                 525             


Asp Thr Pro Tyr Leu Leu Asn Glu Asp Trp Glu Tyr Tyr Leu Ser Gly 
    530                 535                 540                 


Lys Leu Phe Asn Lys Ser Lys Met Lys Leu Thr Phe Glu Gln Val Tyr 
545                 550                 555                 560 


Ser Asp Cys Lys Lys Asn Arg Gly Thr Tyr Gly Thr Leu His Leu Gln 
                565                 570                 575     


Asn Ser Phe Asn Ile Ser Glu His Leu Asn Ile Asn Glu His Thr Gly 
            580                 585                 590         


Ser Ile Ser Ser Glu Leu Glu Ser Leu Lys Val Asn Leu Asn Ile Phe 
        595                 600                 605             


Leu Leu Gly Ala Ala Gly Arg Lys Asn Leu Gln Asp Phe Ala Ala Cys 
    610                 615                 620                 


Gly Ile Asp Arg Met Asn Tyr Asp Ser Tyr Leu Ala Gln Thr Gly Lys 
625                 630                 635                 640 


Ser Pro Ala Gly Val Asn Leu Leu Ser Phe Ala Tyr Asp Leu Glu Ala 
                645                 650                 655     


Lys Ala Asn Ser Leu Pro Pro Gly Asn Leu Arg Asn Ser Leu Lys Arg 
            660                 665                 670         


Asp Ala Gln Thr Ile Lys Thr Ile His Gln Gln Arg Val Leu Pro Ile 
        675                 680                 685             


Glu Gln Ser Leu Ser Thr Leu Tyr Gln Ser Val Lys Ile Leu Gln Arg 
    690                 695                 700                 


Thr Gly Asn Gly Leu Leu Glu Arg Val Thr Arg Ile Leu Ala Ser Leu 
705                 710                 715                 720 


Asp Phe Ala Gln Asn Phe Ile Thr Asn Asn Thr Ser Ser Val Ile Ile 
                725                 730                 735     


Glu Glu Thr Lys Lys Tyr Gly Arg Thr Ile Ile Gly Tyr Phe Glu His 
            740                 745                 750         


Tyr Leu Gln Trp Ile Glu Phe Ser Ile Ser Glu Lys Val Ala Ser Cys 
        755                 760                 765             


Lys Pro Val Ala Thr Ala Leu Asp Thr Ala Val Asp Val Phe Leu Cys 
    770                 775                 780                 


Ser Tyr Ile Ile Asp Pro Leu Asn Leu Phe Trp Phe Gly Ile Gly Lys 
785                 790                 795                 800 


Ala Thr Val Phe Leu Leu Pro Ala Leu Ile Phe Ala Val Lys Leu Ala 
                805                 810                 815     


Lys Tyr Tyr Arg Arg Met Asp Ser Glu Asp Val Tyr Asp Asp Ser Ser 
            820                 825                 830         


Trp Val Thr Ser Val Gln Val Asn Phe Phe Phe Leu Val Leu Ile Phe 
        835                 840                 845             


Leu Tyr Leu Phe 
    850         


<210>  8
<211>  851
<212>  PRT
<213>  Canis lupus familiaris

<400>  8

Met Ala Leu Leu Leu Gly Phe Leu Leu Leu Leu Glu Leu Cys Trp Asp 
1               5                   10                  15      


Thr Ser Ala Leu Gly Pro Leu Ser Ser Thr Lys Gly Ser Asp Gly Leu 
            20                  25                  30          


Glu Phe Glu Leu Pro Ala Thr Asn Tyr Glu Thr Lys Asp Ser Asn Gln 
        35                  40                  45              


Ala Gly Pro Ile Ser Val Leu Phe Gln Ile Val Gln Val Phe Leu Gln 
    50                  55                  60                  


Val Val Gln Pro His Pro Phe Pro Glu Asp Ile Leu Arg Lys Ile Leu 
65                  70                  75                  80  


Gln Lys Lys Phe Asp Phe Ser Thr Asp Tyr Asp Lys Pro Glu Asn Val 
                85                  90                  95      


Val Leu Thr Leu Lys Ile Ile Tyr Tyr Glu Ile Gly Ile Ile Ile Cys 
            100                 105                 110         


Ala Val Leu Gly Leu Leu Phe Val Ile Leu Met Pro Leu Val Gly Phe 
        115                 120                 125             


Cys Phe Gly Leu Cys Arg Cys Cys Asn Lys Cys Gly Gly Glu Met His 
    130                 135                 140                 


Gln Arg Gln Lys Lys Asn Gly Ala Phe Leu Arg Lys Tyr Phe Thr Val 
145                 150                 155                 160 


Ser Leu Leu Val Ile Cys Ile Phe Ile Ser Val Gly Ile Ile Tyr Gly 
                165                 170                 175     


Phe Val Ala Asn His His Leu Arg Thr Arg Ile Glu Lys Thr Arg Lys 
            180                 185                 190         


Leu Ala Glu Ser Asn Leu Lys Asp Leu Arg Thr Leu Leu Ile Gly Thr 
        195                 200                 205             


Pro Ala Gln Ile Asn Tyr Val Leu Ser Gln Tyr Ala Ser Thr Lys Glu 
    210                 215                 220                 


Lys Ala Phe Ser Asp Leu Asp Asn Ile Lys Ser Leu Leu Gly Gly Gly 
225                 230                 235                 240 


Ile His Asp Gln Leu Arg Pro Lys Val Ile Pro Val Leu Asp Asp Ile 
                245                 250                 255     


Lys Ala Met Ala Glu Ala Ile Lys Glu Thr Arg Glu Ala Leu Leu Asn 
            260                 265                 270         


Val Asn Asn Thr Leu Lys Glu Leu Lys Met Ser Thr Ala Gln Leu Asn 
        275                 280                 285             


Thr Ser Leu Ser Asp Val Lys Arg Asn Leu Glu Gln Ser Leu Asn Asp 
    290                 295                 300                 


Pro Met Cys Ser Val Pro Pro Val Ala Thr Thr Cys Asn Asn Ile Arg 
305                 310                 315                 320 


Met Ser Leu Gly Gln Leu Asp Asp Asn Thr Asn Leu Gly Gln Leu Pro 
                325                 330                 335     


Ser Leu Asp Lys Gln Ile Asp Asn Ile Asn Asn Val Leu Gln Thr Asp 
            340                 345                 350         


Leu Ser Ser Leu Val Gln Lys Gly Tyr Lys Ser Phe Asn Asp Ile Pro 
        355                 360                 365             


Glu Met Val Gln Asn Gln Thr Thr Asp Ile Val Ser Ala Leu Pro Tyr 
    370                 375                 380                 


Val Lys Arg Thr Leu Asn Ser Leu Gly Ser Asp Ile Glu Asn Met Ser 
385                 390                 395                 400 


Glu Gln Ile Pro Ile Gln Asp Lys Leu Ser Asp Phe Ile Gly Tyr Ile 
                405                 410                 415     


Asn Asp Thr Glu Thr Tyr Ile His Arg Asn Leu Pro Thr Leu Glu Glu 
            420                 425                 430         


Tyr Asp Ser Tyr Arg Trp Leu Gly Gly Leu Ile Val Cys Cys Leu Leu 
        435                 440                 445             


Thr Leu Ile Val Val Phe Tyr Tyr Leu Gly Leu Met Cys Gly Thr Phe 
    450                 455                 460                 


Gly Tyr Asp Arg His Ala Thr Pro Thr Arg Arg Gly Cys Val Ser Asn 
465                 470                 475                 480 


Thr Gly Gly Ile Phe Leu Met Val Gly Val Gly Ile Ser Phe Leu Phe 
                485                 490                 495     


Cys Trp Ile Leu Met Thr Ile Val Val Leu Thr Phe Val Ile Gly Gly 
            500                 505                 510         


Asn Met Glu Lys Leu Val Cys Glu Pro Tyr Gln Asn Arg Lys Leu Phe 
        515                 520                 525             


Gln Ile Leu Asp Thr Pro Tyr Leu Leu Asn Glu Asn Trp Lys Tyr Tyr 
    530                 535                 540                 


Leu Ser Gly Met Val Leu Asp Lys Pro Asp Ile Asn Leu Thr Phe Glu 
545                 550                 555                 560 


Gln Val Tyr Ser Asp Cys Lys Glu Asn Lys Gly Ile Tyr Ser Thr Leu 
                565                 570                 575     


Lys Leu Glu Asn Thr Tyr Asn Ile Ser Glu His Leu Asn Ile Gln Glu 
            580                 585                 590         


His Ala Arg Asn Leu Ser Asn Asp Phe Lys Asn Met Asn Val Asn Ile 
        595                 600                 605             


Asp Asn Ile Val Leu Leu Asp Ala Ala Gly Arg Lys Asn Leu Met Asp 
    610                 615                 620                 


Phe Ser Ser Ser Gly Val Asp Thr Ile Asp Tyr Asn Val Tyr Leu Ala 
625                 630                 635                 640 


Glu Met Gly Lys Thr Pro Thr Lys Val Asn Leu Leu Ser Phe Ala Asp 
                645                 650                 655     


Asp Leu Asp Thr Lys Ala Asn Asn Leu Pro Gln Gly Ser Leu Lys Gln 
            660                 665                 670         


Ser Leu Lys Asn Asn Ala Gln Asn Leu Lys Thr Ile His His Gly Gln 
        675                 680                 685             


Val Met Pro Leu Glu Gln Ser Met Lys Tyr Gly Lys Ala Arg Ser Thr 
    690                 695                 700                 


Ile Asn Gln Ser Ile Lys Glu Leu Gln His Lys Ser Ser Gly Leu Arg 
705                 710                 715                 720 


Val Lys Val Ala Asn Ile Leu Ser Ser Leu Asp Ser Ala Gln Asp Phe 
                725                 730                 735     


Leu Gln Thr Arg Ile Ser Ser Val Ile Val Lys Glu Ser Ser Lys Tyr 
            740                 745                 750         


Gly Asn Met Ile Ile Gly Tyr Phe Glu His Tyr Leu Gln Trp Val Lys 
        755                 760                 765             


Ile Ser Ile Thr Glu Gln Ile Ala Ala Cys Lys Pro Val Ala Thr Ala 
    770                 775                 780                 


Leu Asp Ser Ala Val Asp Val Phe Leu Cys Ser Tyr Ile Ile Asp Pro 
785                 790                 795                 800 


Met Asn Leu Phe Trp Phe Gly Ile Gly Lys Ala Thr Ile Phe Leu Leu 
                805                 810                 815     


Pro Ala Ile Ile Phe Ala Val Lys Leu Ala Lys Tyr Tyr Arg Arg Met 
            820                 825                 830         


Asp Ser Glu Asp Val Tyr Asp Asp Ser Ser Val Leu Gly Thr Trp His 
        835                 840                 845             


Phe Thr Leu 
    850     


<210>  9
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypolypeptide of mAb47-10 heavy chain

<400>  9

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro 
            20                  25                  30          


Gly Thr Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Asn 
        35                  40                  45              


Asn Tyr Asn Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Ala Thr Phe Gly Ser Asp Ser Ile Tyr Tyr Ala Thr Trp 
65                  70                  75                  80  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu 
                85                  90                  95      


Lys Met Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
            100                 105                 110         


Arg Gly Gly Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gln Pro Lys Ala Pro Ser Val Phe Pro Leu Ala Pro Cys Cys Gly Asp 
    130                 135                 140                 


Thr Pro Ser Ser Thr Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Leu 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Thr Leu Thr Asn Gly 
                165                 170                 175     


Val Arg Thr Phe Pro Ser Val Arg Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Ser Val Thr Ser Ser Ser Gln Pro Val Thr Cys Asn 
        195                 200                 205             


Val Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys Thr Val Ala Pro 
    210                 215                 220                 


Ser Thr Cys Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Asp 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val Arg 
        275                 280                 285             


Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile Arg 
    290                 295                 300                 


Val Val Ser Thr Leu Pro Ile Ala His Gln Asp Trp Leu Arg Gly Lys 
305                 310                 315                 320 


Glu Phe Lys Cys Lys Val His Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys Val Tyr 
            340                 345                 350         


Thr Met Gly Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser Val Ser Leu 
        355                 360                 365             


Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp 
    370                 375                 380                 


Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Pro 
                405                 410                 415     


Thr Ser Glu Trp Gln Arg Gly Asp Val Phe Thr Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile Ser Arg Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  10
<211>  1342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide encoding mAb47-10 heavy chain

<400>  10
atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag       60

tcggtggagg agtccggggg tcgcctggtc acgcctggga cacccctgac actcacctgc      120

accgtctctg gaatcgacct caataactat aacatgcaat gggtccgcca ggctccaggg      180

aaggggctgg aatggatcgg ggccactttt ggtagtgata gtatatacta cgcgacctgg      240

gcgaaaggcc gattcaccat ctccaaaacc tcgaccacgg tggatctgaa aatgaccagt      300

ctgacaaccg aggacacggc cacctatttc tgtgccagag gtggtctctg gggcccaggc      360

accctggtca ccgtctcctc agggcaacct aaggctccat cagtcttccc actggccccc      420

tgctgcgggg acacacccag ctccacggtg accctgggct gcctggtcaa agggtacctc      480

ccggagccag tgaccgtgac ctggaactcg ggcaccctca ccaatggggt acgcaccttc      540

ccgtccgtcc ggcagtcctc aggcctctac tcgctgagca gcgtggtgag cgtgacctca      600

agcagccagc ccgtcacctg caacgtggcc cacccagcca ccaacaccaa agtggacaag      660

accgttgcgc cctcgacatg cagcaagccc acgtgcccac cccctgaact cctgggggga      720

ccgtctgtct tcatcttccc cccaaaaccc aaggacaccc tcatgatctc acgcaccccc      780

gaggtcacat gcgtggtggt ggacgtgagc caggatgacc ccgaggtgca gttcacatgg      840

tacataaaca acgagcaggt gcgcaccgcc cggccgccgc tacgggagca gcagttcaac      900

agcacgatcc gcgtggtcag caccctcccc atcgcgcacc aggactggct gaggggcaag      960

gagttcaagt gcaaagtcca caacaaggca ctcccggccc ccatcgagaa aaccatctcc     1020

aaagccagag ggcagcccct ggagccgaag gtctacacca tgggccctcc ccgggaggag     1080

ctgagcagca ggtcggtcag cctgacctgc atgatcaacg gcttctaccc ttccgacatc     1140

tcggtggagt gggagaagaa cgggaaggca gaggacaact acaagaccac gccggccgtg     1200

ctggacagcg acggctccta cttcctctac agcaagctct cagtgcccac gagtgagtgg     1260

cagcggggcg acgtcttcac ctgctccgtg atgcacgagg ccttgcacaa ccactacacg     1320

cagaagtcca tctcccgctc tc                                              1342


<210>  11
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypolypeptide of mAb47-10 light chain

<400>  11

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Val Thr Phe Ala Gln Val Leu Thr Gln Thr Ala Ser Pro 
            20                  25                  30          


Val Ser Ala Ala Val Gly Ala Thr Val Thr Ile Asn Cys Gln Ser Ser 
        35                  40                  45              


Gln Ser Val Tyr Asn Asn Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser 
65                  70                  75                  80  


Gly Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Ala 
                85                  90                  95      


Leu Thr Ile Ser Gly Val Gln Cys Asp Asp Ala Gly Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gly Glu Phe Ser Cys Asp Ser Ala Asp Cys Ala Ala Phe Gly Gly 
        115                 120                 125             


Gly Thr Glu Val Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu 
    130                 135                 140                 


Ile Phe Pro Pro Ala Ala Asp Gln Val Ala Thr Gly Thr Val Thr Ile 
145                 150                 155                 160 


Val Cys Val Ala Asn Lys Tyr Phe Pro Asp Val Thr Val Thr Trp Glu 
                165                 170                 175     


Val Asp Gly Thr Thr Gln Thr Thr Gly Ile Glu Asn Ser Lys Thr Pro 
            180                 185                 190         


Gln Asn Ser Ala Asp Cys Thr Tyr Asn Leu Ser Ser Thr Leu Thr Leu 
        195                 200                 205             


Thr Ser Thr Gln Tyr Asn Ser His Lys Glu Tyr Thr Cys Lys Val Thr 
    210                 215                 220                 


Gln Gly Thr Thr Ser Val Val Gln Ser Phe Asn Arg Gly Asp Cys 
225                 230                 235                 


<210>  12
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide encoding mAb47-10 light chain

<400>  12
atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgtc       60

acatttgccc aagtgctgac ccagactgca tcgcccgtgt ctgcagctgt gggcgccacc      120

gtcaccatca actgccagtc cagtcagagt gtttataata acaactactt agcctggttt      180

cagcagaaac cagggcagcc tcccaagctc ctgatctaca gggcatccac tctggcttct      240

ggggtctcat cgcggttcaa aggcagtgga tctgggacac agttcgctct caccatcagc      300

ggcgtgcagt gtgacgatgc tggcacttac tattgtcaag gcgaatttag ttgtgatagt      360

gctgattgtg ctgctttcgg cggagggacc gaggtggtgg tcaaaggtga tccagttgca      420

cctactgtcc tcatcttccc accagctgct gatcaggtgg caactggaac agtcaccatc      480

gtgtgtgtgg cgaataaata ctttcccgat gtcaccgtca cctgggaggt ggatggcacc      540

acccaaacaa ctggcatcga gaacagtaaa acaccgcaga attctgcaga ttgtacctac      600

aacctcagca gcactctgac actgaccagc acacagtaca acagccacaa agagtacacc      660

tgcaaggtga cccagggcac gacctcagtc gtccagagct tcaatagggg tgactgt         717


<210>  13
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypolypeptide of mAb133-3 heavy chain

<400>  13

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro 
            20                  25                  30          


Gly Thr Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
        35                  40                  45              


Arg Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp 
    50                  55                  60                  


Trp Ile Gly Tyr Ile Asp Ile Gly Gly Gly Ala Tyr Tyr Ala Ser Trp 
65                  70                  75                  80  


Ala Lys Gly Arg Phe Thr Ile Ser Glu Thr Ser Thr Thr Val Tyr Leu 
                85                  90                  95      


Lys Val Asn Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
            100                 105                 110         


Arg Gly Val Ala Asn Ser Asp Ile Trp Gly Pro Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser Gly Gln Pro Lys Ala Pro Ser Val Phe Pro Leu Ala Pro 
    130                 135                 140                 


Cys Cys Gly Asp Thr Pro Ser Ser Thr Val Thr Leu Gly Cys Leu Val 
145                 150                 155                 160 


Lys Gly Tyr Leu Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Thr 
                165                 170                 175     


Leu Thr Asn Gly Val Arg Thr Phe Pro Ser Val Arg Gln Ser Ser Gly 
            180                 185                 190         


Leu Tyr Ser Leu Ser Ser Val Val Ser Val Thr Ser Ser Ser Gln Pro 
        195                 200                 205             


Val Thr Cys Asn Val Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Thr Val Ala Pro Ser Thr Cys Ser Lys Pro Thr Cys Pro Pro Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser Gln Asp Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn Asn 
        275                 280                 285             


Glu Gln Val Arg Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe Asn 
    290                 295                 300                 


Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile Ala His Gln Asp Trp 
305                 310                 315                 320 


Leu Arg Gly Lys Glu Phe Lys Cys Lys Val His Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu Glu 
            340                 345                 350         


Pro Lys Val Tyr Thr Met Gly Pro Pro Arg Glu Glu Leu Ser Ser Arg 
        355                 360                 365             


Ser Val Ser Leu Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ser Val Glu Trp Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Ala Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Ser Val Pro Thr Ser Glu Trp Gln Arg Gly Asp Val Phe Thr Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile 
        435                 440                 445             


Ser Arg Ser Pro Gly Lys 
    450                 


<210>  14
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide encoding mAb133-3 heavy chain

<400>  14
atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag       60

tcggtggagg agtccggggg tcgcctggtc acgcctggga cacccctgac actcacctgc      120

acagtctctg gattctccct cagtaggtat gcaatgagct gggtccgcca ggctccaggg      180

aagggactgg actggatcgg gtatattgat attggtggtg gcgcatacta cgcgagctgg      240

gcgaaaggtc gattcaccat ctccgagacc tcgaccacgg tgtacctgaa agtcaacagt      300

ccgacaaccg aggacacggc cacctatttc tgtgccagag gtgttgctaa tagtgacatc      360

tggggcccag gcaccctggt caccgtctcc tcagggcaac ctaaggctcc atcagtcttc      420

ccactggccc cctgctgcgg ggacacaccc agctccacgg tgaccctggg ctgcctggtc      480

aaagggtacc tcccggagcc agtgaccgtg acctggaact cgggcaccct caccaatggg      540

gtacgcacct tcccgtccgt ccggcagtcc tcaggcctct actcgctgag cagcgtggtg      600

agcgtgacct caagcagcca gcccgtcacc tgcaacgtgg cccacccagc caccaacacc      660

aaagtggaca agaccgttgc gccctcgaca tgcagcaagc ccacgtgccc accccctgaa      720

ctcctggggg gaccgtctgt cttcatcttc cccccaaaac ccaaggacac cctcatgatc      780

tcacgcaccc ccgaggtcac atgcgtggtg gtggacgtga gccaggatga ccccgaggtg      840

cagttcacat ggtacataaa caacgagcag gtgcgcaccg cccggccgcc gctacgggag      900

cagcagttca acagcacgat ccgcgtggtc agcaccctcc ccatcgcgca ccaggactgg      960

ctgaggggca aggagttcaa gtgcaaagtc cacaacaagg cactcccggc ccccatcgag     1020

aaaaccatct ccaaagccag agggcagccc ctggagccga aggtctacac catgggccct     1080

ccccgggagg agctgagcag caggtcggtc agcctgacct gcatgatcaa cggcttctac     1140

ccttccgaca tctcggtgga gtgggagaag aacgggaagg cagaggacaa ctacaagacc     1200

acgccggccg tgctggacag cgacggctcc tacttcctct acagcaagct ctcagtgccc     1260

acgagtgagt ggcagcgggg cgacgtcttc acctgctccg tgatgcacga ggccttgcac     1320

aaccactaca cgcagaagtc catctcccgc tctccgggta aa                        1362


<210>  15
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypolypeptide of mAb133-3 light chain

<400>  15

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys Ala Leu Val Met Thr Gln Thr Pro Ser Pro 
            20                  25                  30          


Val Ser Ala Ala Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ser Ser 
        35                  40                  45              


Gln Ser Val Phe Asn Asn Lys Trp Leu Ser Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Phe Val Ser Thr Leu Ala Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Gly Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gly Ser Asp Tyr Ser Ser Gly Trp Tyr Ser Pro Phe Gly Gly Gly 
        115                 120                 125             


Thr Glu Val Val Val Glu Gly Asp Pro Val Ala Pro Thr Val Leu Ile 
    130                 135                 140                 


Phe Pro Pro Ala Ala Asp Gln Val Ala Thr Gly Thr Val Thr Ile Val 
145                 150                 155                 160 


Cys Val Ala Asn Lys Tyr Phe Pro Asp Val Thr Val Thr Trp Glu Val 
                165                 170                 175     


Asp Gly Thr Thr Gln Thr Thr Gly Ile Glu Asn Ser Lys Thr Pro Gln 
            180                 185                 190         


Asn Ser Ala Asp Cys Thr Tyr Asn Leu Ser Ser Thr Leu Thr Leu Thr 
        195                 200                 205             


Ser Thr Gln Tyr Asn Ser His Lys Glu Tyr Thr Cys Lys Val Thr Gln 
    210                 215                 220                 


Gly Thr Thr Ser Val Val Gln Ser Phe Asn Arg Gly Asp Cys 
225                 230                 235             


<210>  16
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide encoding mAb133-3 light chain

<400>  16
atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc       60

agatgtgccc ttgtgatgac ccagactcca tcccccgtgt ctgcagctgt gggaggcaca      120

gtcaccatca attgccagtc cagtcagagt gtttttaata ataaatggtt atcctggtat      180

cagcagaaac cagggcagcc tcccaagctc ctgatctatt ttgtatccac tctggcatct      240

ggggtcccat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcagc      300

ggcgtgcagt gtgacgatgc tgccacttac tactgtcaag gcagtgatta tagtagtggt      360

tggtatagtc ctttcggcgg agggaccgag gtggtggtcg aaggtgatcc agttgcacct      420

actgtcctca tcttcccacc agctgctgat caggtggcaa ctggaacagt caccatcgtg      480

tgtgtggcga ataaatactt tcccgatgtc accgtcacct gggaggtgga tggcaccacc      540

caaacaactg gcatcgagaa cagtaaaaca ccgcagaatt ctgcagattg tacctacaac      600

ctcagcagca ctctgacact gaccagcaca cagtacaaca gccacaaaga gtacacctgc      660

aaggtgaccc agggcacgac ctcagtcgtc cagagcttca ataggggtga ctgt            714


<210>  17
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic domain A immunogenic polypeptide

<400>  17

Lys Thr Ser Leu Arg Ser Ser Leu Asn Asp Pro Leu Cys Leu Val His 
1               5                   10                  15      


Pro Ser Ser Glu Thr Cys Asn Ser Ile Arg Leu Ser Leu Ser Gln Leu 
            20                  25                  30          


Asn Ser Asn 
        35  


<210>  18
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic CD133 domain B immunogenic polypeptide

<400>  18

Arg Lys Asn Leu Gln Asp Phe Ala Ala Cys Gly Ile Asp Arg Met Asn 
1               5                   10                  15      


Tyr Asp Ser Tyr Leu Ala Gln Thr Gly Lys Ser Pro Ala Lys 
            20                  25                  30  


<210>  19
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic recombinant CD133 domain A immunogenic polypeptide

<400>  19

Met His His His His His His Ser Ser Gly Val Asp Leu Gly Thr Glu 
1               5                   10                  15      


Asn Leu Tyr Phe Gln Ser Asn Ala Asn His Gln Val Arg Thr Arg Ile 
            20                  25                  30          


Lys Arg Ser Arg Lys Leu Ala Asp Ser Asn Phe Lys Asp Leu Arg Thr 
        35                  40                  45              


Leu Leu Asn Glu Thr Pro Glu Gln Ile Lys Tyr Ile Leu Ala Gln Tyr 
    50                  55                  60                  


Asn Thr Thr Lys Asp Lys Ala Phe Thr Asp Leu Asn Ser Ile Asn Ser 
65                  70                  75                  80  


Val Leu Gly Gly Gly Ile Leu Asp Arg Leu Arg Pro Asn Ile Ile Pro 
                85                  90                  95      


Val Leu Asp Glu Ile Lys Ser Met Ala Thr Ala Ile Lys Glu Thr Lys 
            100                 105                 110         


Glu Ala Leu Glu Asn Met Asn Ser Thr Leu Lys Ser Leu His Gln Gln 
        115                 120                 125             


Ser Thr Gln Leu Ser Ser Ser Leu Thr Ser Val Lys Thr Ser Leu Arg 
    130                 135                 140                 


Ser Ser Leu Asn Asp Pro Leu Cys Leu Val His Pro Ser Ser Glu Thr 
145                 150                 155                 160 


Cys Asn Ser Ile Arg Leu Ser Leu Ser Gln Leu Asn Ser Asn Pro Glu 
                165                 170                 175     


Leu Arg Gln Leu Pro Pro Val Asp Ala Glu Leu Asp Asn Val Asn Asn 
            180                 185                 190         


Val Leu Arg Thr Asp Leu Asp Gly Leu Val Gln Gln Gly Tyr Gln Ser 
        195                 200                 205             


Leu Asn Asp Ile Pro Asp Arg Val Gln Arg Gln Thr Thr Thr Val Val 
    210                 215                 220                 


Ala Gly Ile Lys Arg Val Leu Asn Ser Ile Gly Ser Asp Ile Asp Asn 
225                 230                 235                 240 


Val Thr Gln Arg Leu 
                245 


<210>  20
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic recombinant CD133 domain B immunogenic polypeptide

<400>  20

Met His His His His His His Ser Ser Gly Val Asp Leu Gly Thr Glu 
1               5                   10                  15      


Asn Leu Tyr Phe Gln Ser Asn Ala Ile Cys Glu Pro Tyr Thr Ser Lys 
            20                  25                  30          


Glu Leu Phe Arg Val Leu Asp Thr Pro Tyr Leu Leu Asn Glu Asp Trp 
        35                  40                  45              


Glu Tyr Tyr Leu Ser Gly Lys Leu Phe Asn Lys Ser Lys Met Lys Leu 
    50                  55                  60                  


Thr Phe Glu Gln Val Tyr Ser Asp Cys Lys Lys Asn Arg Gly Thr Tyr 
65                  70                  75                  80  


Gly Thr Leu His Leu Gln Asn Ser Phe Asn Ile Ser Glu His Leu Asn 
                85                  90                  95      


Ile Asn Glu His Thr Gly Ser Ile Ser Ser Glu Leu Glu Ser Leu Lys 
            100                 105                 110         


Val Asn Leu Asn Ile Phe Leu Leu Gly Ala Ala Gly Arg Lys Asn Leu 
        115                 120                 125             


Gln Asp Phe Ala Ala Cys Gly Ile Asp Arg Met Asn Tyr Asp Ser Tyr 
    130                 135                 140                 


Leu Ala Gln Thr Gly Lys Ser Pro Ala Gly Val Asn Leu Leu Ser Phe 
145                 150                 155                 160 


Ala Tyr Asp Leu Glu Ala Lys Ala Asn Ser Leu Pro Pro Gly Asn Leu 
                165                 170                 175     


Arg Asn Ser Leu Lys Arg Asp Ala Gln Thr Ile Lys Thr Ile His Gln 
            180                 185                 190         


Gln Arg Val Leu Pro Ile Glu Gln Ser Leu Ser Thr Leu Tyr Gln Ser 
        195                 200                 205             


Val Lys Ile Leu Gln Arg Thr Gly Asn Gly Leu Leu Glu Arg Val Thr 
    210                 215                 220                 


Arg Ile Leu Ala Ser Leu Asp Phe Ala Gln Asn Phe Ile Thr Asn Asn 
225                 230                 235                 240 


Thr Ser Ser Val Ile Ile Glu Glu Thr Lys Lys Tyr Gly Arg Thr 
                245                 250                 255 


