                         SEQUENCE LISTING

<110>  The California Institute for Biomedical Research
       Young, Travis
       Kim, Chanhyuk
       Peter , Schultz G.
 
<120>  SWITCHABLE NON-scFv CHIMERIC RECEPTORS, SWITCHES, AND USES THEREOF

<130>  CIBR-007/01WO  323414-2030

<150>  US 62/138,901
<151>  2015-03-26

<160>  76    

<170>  PatentIn version 3.5

<210>  1
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric receptor with DDD1 module

<400>  1
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgtcacata tccagatccc ccccggactg actgaactgc tgcagggcta taccgtggaa      120

gtgctgagac agcagcctcc cgacctggtg gagttcgccg tggaatactt tacccggctg      180

agggaggcac gggctggagg cggaggttca ggaggaggag ggagtggcgg aggcggtagc      240

accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg      300

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      360

gacttcgcct gtgatatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc      420

ctgtcactgg ttatcaccct ttactgcaaa cggggcagaa agaaactcct gtatatattc      480

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga      540

tttccagaag aagaagaagg aggatgtgaa ctgagagtga agttcagcag gagcgcagac      600

gcccccgcgt acaagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga      660

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg      720

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag      780

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt      840

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg      900

ccccctcgct aa                                                          912


<210>  2
<211>  831
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric receptor with AD1 module

<400>  2
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcagattg agtacctggc taaacagatt gtggataacg ctattcagca ggcaggcgga      120

ggtggatctg gaggcggtgg gtcaggtgga ggcggaagta ccacgacgcc agcgccgcga      180

ccaccaacac cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc      240

cggccagcgg cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatatctac      300

atctgggcgc ccttggccgg gacttgtggg gtccttctcc tgtcactggt tatcaccctt      360

tactgcaaac ggggcagaaa gaaactcctg tatatattca aacaaccatt tatgagacca      420

gtacaaacta ctcaagagga agatggctgt agctgccgat ttccagaaga agaagaagga      480

ggatgtgaac tgagagtgaa gttcagcagg agcgcagacg cccccgcgta caagcagggc      540

cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga tgttttggac      600

aagagacgtg gccgggaccc tgagatgggg ggaaagccga gaaggaagaa ccctcaggaa      660

ggcctgtaca atgaactgca gaaagataag atggcggagg cctacagtga gattgggatg      720

aaaggcgagc gccggagggg caaggggcac gatggccttt accagggtct cagtacagcc      780

accaaggaca cctacgacgc ccttcacatg caggccctgc cccctcgcta a               831


<210>  3
<211>  903
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Switch with DDD1 module and anti-CD19 huB4 heavy chain

<400>  3
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg       60

caggtgcagc tggtccagcc aggggcagag gtcgtcaagc caggagcatc cgtcaaactg      120

tcatgtaaaa caagcgggta tactttcacc agcaattgga tgcactgggt gaagcaggcc      180

cccggacagg gcctggagtg gatcggggaa attgacccta gtgattcata cactaactac      240

aaccagaact tccagggaaa ggccaaactg accgtggaca aaagcacctc cacagcttat      300

atggaggtga gcagcctgcg gtccgacgat actgcagtct actattgcgc cagaggctct      360

aacccttact attacgctat ggattactgg gggcagggaa caagcgtgac tgtctctagt      420

gcatcaacaa agggaccaag cgtgtttcca ctggccccct caagcaagag cacctccgga      480

gggacagccg ctctgggatg tctggtgaaa gactacttcc ccgagcctgt gactgtctct      540

tggaatagtg gcgctctgac ctccggggtg cacacatttc cagcagtcct gcagtcctct      600

ggactgtatt ctctgagttc agtggtcacc gtgcccagct cctctctggg cactcagacc      660

tacatctgca atgtcaacca taagcctagt aacacaaaag tggataagaa agtcgaacca      720

aagagctgtg gcggagggag cggaggaggc ggtagcggcg ggggaggctc acatatccag      780

attccaccag ggctgacaga actgctgcag ggctacaccg tggaggtcct gcggcagcag      840

ccccctgacc tggtggagtt cgctgtggaa tactttacaa ggctgcggga ggctcgggct      900

taa                                                                    903


<210>  4
<211>  903
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Switch with AD1 module and anti-CD19 huB4 heavy chain

<400>  4
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg       60

caggtgcagc tggtccagcc aggggcagag gtcgtcaagc caggagcatc cgtcaaactg      120

tcatgtaaaa caagcgggta tactttcacc agcaattgga tgcactgggt gaagcaggcc      180

cccggacagg gcctggagtg gatcggggaa attgacccta gtgattcata cactaactac      240

aaccagaact tccagggaaa ggccaaactg accgtggaca aaagcacctc cacagcttat      300

atggaggtga gcagcctgcg gtccgacgat actgcagtct actattgcgc cagaggctct      360

aacccttact attacgctat ggattactgg gggcagggaa caagcgtgac tgtctctagt      420

gcatcaacaa agggaccaag cgtgtttcca ctggccccct caagcaagag cacctccgga      480

gggacagccg ctctgggatg tctggtgaaa gactacttcc ccgagcctgt gactgtctct      540

tggaatagtg gcgctctgac ctccggggtg cacacatttc cagcagtcct gcagtcctct      600

ggactgtatt ctctgagttc agtggtcacc gtgcccagct cctctctggg cactcagacc      660

tacatctgca atgtcaacca taagcctagt aacacaaaag tggataagaa agtcgaacca      720

aagagctgtg gcggagggag cggaggaggc ggtagcggcg ggggaggctc acatatccag      780

attccaccag ggctgacaga actgctgcag ggctacaccg tggaggtcct gcggcagcag      840

ccccctgacc tggtggagtt cgctgtggaa tactttacaa ggctgcggga ggctcgggct      900

taa                                                                    903


<210>  5
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD19 huB4 light chain

<400>  5
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg       60

gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc      120

atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca      180

gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca      240

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      300

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg      360

gggaccaagc ttgagatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca      420

tctgatgagc agttgaaatc tggaactgcc tctgtcgtgt gcctgctgaa taacttctat      480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      660

ctgtcctcgc ccgtcacaaa gagcttcaac aggggagagt gttaa                      705


<210>  6
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Isopeptag amino acid peptide tag

<400>  6

Thr Asp Lys Asp Met Thr Ile Thr Phe Thr Asn Lys Lys Asp Ala Glu 
1               5                   10                  15      


<210>  7
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide tag

<400>  7

Ala His Ile Val Met Val Asp Ala Tyr Lys Pro Thr Lys 
1               5                   10              


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anchoring domain (AD1) without cysteines

<400>  8

Gln Ile Glu Tyr Leu Ala Lys Gln Ile Val Asp Asn Ala Ile Gln Gln 
1               5                   10                  15      


Ala 
    


<210>  9
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dimerization and docking domain (DDD1) without cysteines

<400>  9

Ser His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly Tyr 
1               5                   10                  15      


Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe Ala 
            20                  25                  30          


Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  


<210>  10
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anchoring domain (AD1) with cysteines

<400>  10

Cys Gly Gln Ile Glu Tyr Leu Ala Lys Gln Ile Val Asp Asn Ala Ile 
1               5                   10                  15      


Gln Gln Ala Gly Cys 
            20      


<210>  11
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dimerization and docking domain (DDD1) with cysteines

<400>  11

Cys Gly His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly 
1               5                   10                  15      


Tyr Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe 
            20                  25                  30          


Ala Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  45  


<210>  12
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker sequence

<400>  12

Gly Gly Gly Gly Ser 
1               5   


<210>  13
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker sequence

<400>  13

Gly Gly Gly Ser 
1               


<210>  14

<400>  14
000

<210>  15

<400>  15
000

<210>  16

<400>  16
000

<210>  17
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker sequence

<400>  17

Leu Val Gly Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10                  


<210>  18
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker sequence

<400>  18

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10          


<210>  19
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker sequence

<400>  19

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10                  15      


<210>  20
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker sequence

<400>  20

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  21
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker sequence

<400>  21

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr 
1               5                   10                  


<210>  22
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker sequence

<400>  22

Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10          


<210>  23
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker sequence

<400>  23

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10                  


<210>  24
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain of anti-CS1 antibody

<400>  24

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Ile Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  25
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain of anti-CS1 antibody Fab

<400>  25

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  


Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Asp Gly Asn Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220         


<210>  26
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain of anti-EGFRvIII antibody (Hu806) Fab

<400>  26

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ser Ser Gln Asp Ile Asn Ser Asn 
            20                  25                  30          


Ile Gly Trp Leu Gln Gln Lys Pro Gly Lys Ser Phe Lys Gly Leu Ile 
        35                  40                  45              


Tyr His Gly Thr Asn Leu Asp Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Tyr Ala Gln Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  27
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain of anti-EGFRvIII antibody (Hu806) Fab

<400>  27

Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu 
1               5                   10                  15      


Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Ser Ser Asp Phe Ala 
            20                  25                  30          


Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Tyr Ile Ser Tyr Ser Gly Asn Thr Arg Tyr Gln Pro Ser Leu Lys Ser 
    50                  55                  60                  


Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu Lys 
65                  70                  75                  80  


Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys Val Thr 
                85                  90                  95      


Ala Gly Arg Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
        115                 120                 125             


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
145                 150                 155                 160 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                165                 170                 175     


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            180                 185                 190         


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215         


<210>  28
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain of anti-BCMA antibody (BCMA98) Fab

<400>  28

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Asn Gln Gly Ile Ser Asn Asn 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Thr Ser Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  29
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain of anti-BCMA antibody (BCMA98) Fab

<400>  29

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


<210>  30
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain of anti-CD19 antibody

<400>  30

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  31
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain of anti-CD19 antibody IgG

<400>  31

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  32
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain of anti-CD19 antibody Fab

<400>  32

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220             


<210>  33
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic VAAL K4 alpha helical coiled coil peptide

<400>  33

Lys Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu Lys Val 
1               5                   10                  15      


Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu 
            20                  25              


<210>  34
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic VAAL E4 alpha helical coiled coil peptide

<400>  34

Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val 
1               5                   10                  15      


Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys 
            20                  25              


<210>  35
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E4 Chimeric Receptor nucleotide sequence

<400>  35
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggttg ctgccctgga gaaggaggtg gctgcactgg agaaagaggt ggccgccctg      120

gaaaaagaag tggcagcctt ggagaaggaa agcaagtatg gcccaccttg tccaccttgt      180

cccgatatct acatctgggc gcccttggcc gggacttgtg gggtccttct cctgtcactg      240

gttatcaccc tttactgcaa acggggcaga aagaaactcc tgtatatatt caaacaacca      300

tttatgagac cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa      360

gaagaagaag gaggatgtga actgagagtg aagttcagca ggagcgcaga cgcccccgcg      420

tacaagcagg gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac      480

gatgttttgg acaagagacg tggccgggac cctgagatgg ggggaaagcc gagaaggaag      540

aaccctcagg aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt      600

gagattggga tgaaaggcga gcgccggagg ggcaaggggc acgatggcct ttaccagggt      660

ctcagtacag ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc      720

taa                                                                    723


<210>  36
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  K4 Chimeric Receptor nucleotide sequence

<400>  36
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgaaagtgg cagccctgaa ggagaaagtt gcggctctca aagagaaagt ggctgcactg      120

aaagaaaagg ttgccgccct caaggaggaa agcaagtatg gcccaccttg tccaccttgt      180

cccgatatct acatctgggc gcccttggcc gggacttgtg gggtccttct cctgtcactg      240

gttatcaccc tttactgcaa acggggcaga aagaaactcc tgtatatatt caaacaacca      300

tttatgagac cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa      360

gaagaagaag gaggatgtga actgagagtg aagttcagca ggagcgcaga cgcccccgcg      420

tacaagcagg gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac      480

gatgttttgg acaagagacg tggccgggac cctgagatgg ggggaaagcc gagaaggaag      540

aaccctcagg aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt      600

gagattggga tgaaaggcga gcgccggagg ggcaaggggc acgatggcct ttaccagggt      660

ctcagtacag ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc      720

taa                                                                    723


<210>  37
<211>  831
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fmc63 HCCT E4 switch heavy chain nucleotide sequence

<400>  37
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg       60

gaggtgaaac tgcaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccgtc      120

acatgcactg tctcaggggt ctcattaccc gactatggtg taagctggat tcgccagcct      180

ccacgaaagg gtctggagtg gctgggagta atatggggta gtgaaaccac atactataat      240

tcagctctca aatccagact gaccatcatc aaggacaact ccaagagcca agttttctta      300

aaaatgaaca gtctgcaaac tgatgacaca gccatttact actgtgccaa acattattac      360

tacggtggta gctatgctat ggactactgg ggccaaggaa cctcagtcac cgtctcctca      420

gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      480

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      540

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      600

ggactctact ccctcagcag cgtggtgact gtgccctcta gcagcttggg cacccagacc      660

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      720

aaatcttgtg gcggaggcgg gagcgaggtt gctgccctgg agaaggaggt ggctgcactg      780

gagaaagagg tggccgccct ggaaaaagaa gtggcagcct tggagaagtg a               831


<210>  38
<211>  832
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fmc63 HCCT K4 switch heavy chain nucleotide sequence

<400>  38
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg       60

gaggtgaaac tgcaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccgtc      120

acatgcactg tctcaggggt ctcattaccc gactatggtg taagctggat tcgccagcct      180

ccacgaaagg gtctggagtg gctgggagta atatggggta gtgaaaccac atactataat      240

tcagctctca aatccagact gaccatcatc aaggacaact ccaagagcca agttttctta      300

aaaatgaaca gtctgcaaac tgatgacaca gccatttact actgtgccaa acattattac      360

tacggtggta gctatgctat ggactactgg ggccaaggaa cctcagtcac cgtctcctca      420

gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      480

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      540

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      600

ggactctact ccctcagcag cgtggtgact gtgccctcta gcagcttggg cacccagacc      660

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      720

aaatcttgtg gcggaggcgg gagcaaagtg gcagccctga aggagaaagt tgcggctctc      780

aaagagaaag tggctgcact gaaagaaaag gttgccgccc tcaaggagtg at              832


<210>  39
<211>  733
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fmc63 HC WT switch heavy chain nucleotide sequence

<400>  39
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg       60

gaggtgaaac tgcaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccgtc      120

acatgcactg tctcaggggt ctcattaccc gactatggtg taagctggat tcgccagcct      180

ccacgaaagg gtctggagtg gctgggagta atatggggta gtgaaaccac atactataat      240

tcagctctca aatccagact gaccatcatc aaggacaact ccaagagcca agttttctta      300

aaaatgaaca gtctgcaaac tgatgacaca gccatttact actgtgccaa acattattac      360

tacggtggta gctatgctat ggactactgg ggccaaggaa cctcagtcac cgtctcctca      420

gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      480

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      540

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      600

ggactctact ccctcagcag cgtggtgact gtgccctcta gcagcttggg cacccagacc      660

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      720

aaatcttgtt gat                                                         733


<210>  40
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fmc63 LC WT switch light chain nucleotide sequence

<400>  40
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg       60

gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc      120

atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca      180

gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca      240

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      300

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg      360

gggaccaagc ttgagatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca      420

tctgatgagc agttgaaatc tggaactgcc tctgtcgtgt gcctgctgaa taacttctat      480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      660

ctgtcctcgc ccgtcacaaa gagcttcaac aggggagagt gttga                      705


<210>  41
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E4 Chimeric Receptor

<400>  41

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala 
            20                  25                  30          


Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu 
        35                  40                  45              


Lys Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Asp Ile Tyr 
    50                  55                  60                  


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
65                  70                  75                  80  


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
                85                  90                  95      


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
            100                 105                 110         


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        115                 120                 125             


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
    130                 135                 140                 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
145                 150                 155                 160 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
                165                 170                 175     


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
            180                 185                 190         


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
        195                 200                 205             


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
    210                 215                 220                 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
225                 230                 235                 240 


<210>  42
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K4 Chimeric Receptor sequence

<400>  42

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Lys Val Ala Ala Leu Lys Glu Lys Val Ala Ala 
            20                  25                  30          


Leu Lys Glu Lys Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys 
        35                  40                  45              


Glu Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Asp Ile Tyr 
    50                  55                  60                  


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
65                  70                  75                  80  


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
                85                  90                  95      


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
            100                 105                 110         


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        115                 120                 125             


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
    130                 135                 140                 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
145                 150                 155                 160 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
                165                 170                 175     


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
            180                 185                 190         


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
        195                 200                 205             


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
    210                 215                 220                 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
225                 230                 235                 240 


<210>  43
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fmc63 HCCT E4 switch heavy chain sequence

<400>  43

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val 
            20                  25                  30          


Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser 
        35                  40                  45              


Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly 
    50                  55                  60                  


Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn 
65                  70                  75                  80  


Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser 
                85                  90                  95      


Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Gly Gly Gly Gly Ser Glu Val Ala Ala Leu Glu Lys Glu 
                245                 250                 255     


Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val Ala 
            260                 265                 270         


Ala Leu Glu Lys 
        275     


<210>  44
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fmc63 HCCT K4 switch heavy chain sequence

<400>  44

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val 
            20                  25                  30          


Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser 
        35                  40                  45              


Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly 
    50                  55                  60                  


Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn 
65                  70                  75                  80  


Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser 
                85                  90                  95      


Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Gly Gly Gly Gly Ser Lys Val Ala Ala Leu Lys Glu Lys 
                245                 250                 255     


Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu Lys Val Ala 
            260                 265                 270         


Ala Leu Lys Glu 
        275     


<210>  45
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fmc63 HC WT Heavy Chain sequence

<400>  45

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn 
            100                 105                 110         


Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  46
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fmc63 LC WT Light Chain sequence

<400>  46

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn 
            100                 105                 110         


Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  47
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2X-E4 Chimeric Receptor sequence

<400>  47

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala 
            20                  25                  30          


Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu 
        35                  40                  45              


Lys Gly Gly Gly Gly Ser Glu Val Ala Ala Leu Glu Lys Glu Val Ala 
    50                  55                  60                  


Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu 
65                  70                  75                  80  


Glu Lys Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Asp Ile 
                85                  90                  95      


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
            100                 105                 110         


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
        115                 120                 125             


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
    130                 135                 140                 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
145                 150                 155                 160 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
                165                 170                 175     


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            180                 185                 190         


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        195                 200                 205             


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    210                 215                 220                 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
225                 230                 235                 240 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                245                 250                 255     


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            260                 265                 270         


Arg 
    


<210>  48
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2X-K4 Chimeric Receptor sequence

<400>  48

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Lys Val Ala Ala Leu Lys Glu Lys Val Ala Ala 
            20                  25                  30          


Leu Lys Glu Lys Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys 
        35                  40                  45              


Glu Gly Gly Gly Gly Ser Lys Val Ala Ala Leu Lys Glu Lys Val Ala 
    50                  55                  60                  


Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu 
65                  70                  75                  80  


Lys Glu Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Asp Ile 
                85                  90                  95      


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
            100                 105                 110         


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
        115                 120                 125             


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
    130                 135                 140                 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
145                 150                 155                 160 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
                165                 170                 175     


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            180                 185                 190         


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        195                 200                 205             


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    210                 215                 220                 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
225                 230                 235                 240 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                245                 250                 255     


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            260                 265                 270         


Arg 
    


<210>  49
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fmc63 HCCT 2X-E4 switch Heavy Chain sequence

<400>  49

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val 
            20                  25                  30          


Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser 
        35                  40                  45              


Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly 
    50                  55                  60                  


Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn 
65                  70                  75                  80  


Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser 
                85                  90                  95      


Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Gly Gly Gly Gly Ser Glu Val Ala Ala Leu Glu Lys Glu 
                245                 250                 255     


Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val Ala 
            260                 265                 270         


Ala Leu Glu Lys Gly Gly Gly Gly Ser Glu Val Ala Ala Leu Glu Lys 
        275                 280                 285             


Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val 
    290                 295                 300                 


Ala Ala Leu Glu Lys 
305                 


<210>  50
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fmc63 HCCT 2X-K4 switch Heavy Chain sequence

<400>  50

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val 
            20                  25                  30          


Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser 
        35                  40                  45              


Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly 
    50                  55                  60                  


Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn 
65                  70                  75                  80  


Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser 
                85                  90                  95      


Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Gly Gly Gly Gly Ser Lys Val Ala Ala Leu Lys Glu Lys 
                245                 250                 255     


Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu Lys Val Ala 
            260                 265                 270         


Ala Leu Lys Glu Gly Gly Gly Gly Ser Lys Val Ala Ala Leu Lys Glu 
        275                 280                 285             


Lys Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu Lys Val 
    290                 295                 300                 


Ala Ala Leu Lys Glu 
305                 


<210>  51
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fmc63 LCCT E4 switch Light Chain sequence

<400>  51

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn 
            100                 105                 110         


Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu 
225                 230                 235                 240 


Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val Ala 
                245                 250                 255     


Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys 
            260                 265         


<210>  52
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fmc63 LCCT K4 Light Chain switch

<400>  52

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn 
            100                 105                 110         


Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Lys 
225                 230                 235                 240 


Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu Lys Val Ala 
                245                 250                 255     


Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu 
            260                 265         


<210>  53
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fmc63 HCNT E4 switch Heavy Chain sequence

<400>  53

Met Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Glu 
1               5                   10                  15      


Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Gly Gly Gly 
            20                  25                  30          


Ser Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
        35                  40                  45              


Val Thr Asn Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val 
    50                  55                  60                  


Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser 
65                  70                  75                  80  


Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly 
                85                  90                  95      


Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn 
            100                 105                 110         


Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser 
        115                 120                 125             


Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile 
    130                 135                 140                 


Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp 
145                 150                 155                 160 


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys 
                165                 170                 175     


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
            180                 185                 190         


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
        195                 200                 205             


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
    210                 215                 220                 


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
225                 230                 235                 240 


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
                245                 250                 255     


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
            260                 265                 270         


Lys Ser Cys 
        275 


<210>  54
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fmc63 HCNT K4 switch Heavy Chain sequence

<400>  54

Met Lys Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu Lys 
1               5                   10                  15      


Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu Gly Gly Gly 
            20                  25                  30          


Ser Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
        35                  40                  45              


Val Thr Asn Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val 
    50                  55                  60                  


Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser 
65                  70                  75                  80  


Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly 
                85                  90                  95      


Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn 
            100                 105                 110         


Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser 
        115                 120                 125             


Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile 
    130                 135                 140                 


Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp 
145                 150                 155                 160 


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys 
                165                 170                 175     


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
            180                 185                 190         


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
        195                 200                 205             


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
    210                 215                 220                 


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
225                 230                 235                 240 


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
                245                 250                 255     


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
            260                 265                 270         


Lys Ser Cys 
        275 


<210>  55
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fmc63 LCNT E4 switch Light Chain sequence

<400>  55

Met Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Glu 
1               5                   10                  15      


Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Gly Gly Gly 
            20                  25                  30          


Ser Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
        35                  40                  45              


Val Thr Asn Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
    50                  55                  60                  


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
65                  70                  75                  80  


Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
                85                  90                  95      


Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser 
            100                 105                 110         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
        115                 120                 125             


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn 
    130                 135                 140                 


Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
145                 150                 155                 160 


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
                165                 170                 175     


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            180                 185                 190         


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        195                 200                 205             


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    210                 215                 220                 


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
225                 230                 235                 240 


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                245                 250                 255     


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            260                 265     


<210>  56
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fmc63 LCNT K4 Light Chain switch

<400>  56

Met Lys Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu Lys 
1               5                   10                  15      


Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu Gly Gly Gly 
            20                  25                  30          


Ser Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
        35                  40                  45              


Val Thr Asn Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
    50                  55                  60                  


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
65                  70                  75                  80  


Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
                85                  90                  95      


Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser 
            100                 105                 110         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
        115                 120                 125             


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn 
    130                 135                 140                 


Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
145                 150                 155                 160 


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
                165                 170                 175     


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            180                 185                 190         


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        195                 200                 205             


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    210                 215                 220                 


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
225                 230                 235                 240 


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                245                 250                 255     


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            260                 265     


<210>  57
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fmc63 HCC1 E4 switch Heavy Chain sequence

<400>  57

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val 
            20                  25                  30          


Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser 
        35                  40                  45              


Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly 
    50                  55                  60                  


Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn 
65                  70                  75                  80  


Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser 
                85                  90                  95      


Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val 
                165                 170                 175     


Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Gly Gly Ser Gly 
            180                 185                 190         


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
        195                 200                 205             


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
    210                 215                 220                 


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
225                 230                 235                 240 


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
                245                 250                 255     


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
            260                 265                 270         


Lys Ser Cys 
        275 


<210>  58
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fmc63 HCC1 K4 switch Heavy Chain sequence

<400>  58

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val 
            20                  25                  30          


Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser 
        35                  40                  45              


Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly 
    50                  55                  60                  


Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn 
65                  70                  75                  80  


Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser 
                85                  90                  95      


Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Lys Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu Lys Val 
                165                 170                 175     


Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu Gly Gly Ser Gly 
            180                 185                 190         


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
        195                 200                 205             


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
    210                 215                 220                 


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
225                 230                 235                 240 


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
                245                 250                 255     


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
            260                 265                 270         


Lys Ser Cys 
        275 


<210>  59
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fmc63 LCC1A E4 switch Light Chain sequence

<400>  59

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn 
            100                 105                 110         


Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Glu 
        195                 200                 205             


Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Gly Gly Gly 
    210                 215                 220                 


Gly Ser Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
225                 230                 235                 240 


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
                245                 250                 255     


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            260                 265                 270     


<210>  60
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fmc63 LCC1A K4 switch Light Chain sequence

<400>  60

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn 
            100                 105                 110         


Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Lys Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu Lys 
        195                 200                 205             


Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu Gly Gly Gly 
    210                 215                 220                 


Gly Ser Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
225                 230                 235                 240 


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
                245                 250                 255     


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            260                 265                 270     


<210>  61
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic E/K helical protein

<400>  61

Glu Val Ser Ala Leu Glu Lys Glu Val Ser Ala Leu Glu Lys Glu Val 
1               5                   10                  15      


Ser Ala Leu Glu Lys Glu Val Ser Ala Leu Glu Lys 
            20                  25              


<210>  62
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic E/K helical peptide

<400>  62

Lys Val Ser Ala Leu Lys Glu Lys Val Ser Ala Leu Lys Glu Lys Val 
1               5                   10                  15      


Ser Ala Leu Lys Glu Lys Val Ser Ala Leu Lys Glu 
            20                  25              


<210>  63
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fmc63 LC BV E4 switch  light chain

<400>  63

Met Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Glu 
1               5                   10                  15      


Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Gly Gly Gly 
            20                  25                  30          


Ser Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
        35                  40                  45              


Val Thr Asn Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
    50                  55                  60                  


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
65                  70                  75                  80  


Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
                85                  90                  95      


Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser 
            100                 105                 110         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
        115                 120                 125             


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn 
    130                 135                 140                 


Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
145                 150                 155                 160 


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
                165                 170                 175     


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            180                 185                 190         


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        195                 200                 205             


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    210                 215                 220                 


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
225                 230                 235                 240 


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                245                 250                 255     


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu 
            260                 265                 270         


Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val Ala 
        275                 280                 285             


Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys 
    290                 295                 


<210>  64
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fmc63 HC BV E4 switch  light chain

<400>  64

Met Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Glu 
1               5                   10                  15      


Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Gly Gly Gly 
            20                  25                  30          


Ser Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
        35                  40                  45              


Val Thr Asn Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val 
    50                  55                  60                  


Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser 
65                  70                  75                  80  


Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly 
                85                  90                  95      


Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn 
            100                 105                 110         


Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser 
        115                 120                 125             


Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile 
    130                 135                 140                 


Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp 
145                 150                 155                 160 


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys 
                165                 170                 175     


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
            180                 185                 190         


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
        195                 200                 205             


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
    210                 215                 220                 


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
225                 230                 235                 240 


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
                245                 250                 255     


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
            260                 265                 270         


Lys Ser Cys Gly Gly Gly Gly Ser Glu Val Ala Ala Leu Glu Lys Glu 
        275                 280                 285             


Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val Ala 
    290                 295                 300                 


Ala Leu Glu Lys 
305             


<210>  65
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic E/K helical peptide

<400>  65

Glu Ile Ala Ala Leu Glu Lys Glu Ile Ala Ala Leu Glu Lys Glu Ile 
1               5                   10                  15      


Ala Ala Leu Glu Lys 
            20      


<210>  66
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic E/K helical peptide

<400>  66

Glu Ile Ala Ala Leu Glu Lys Glu Ile Ala Ala Leu Glu Lys Glu Ile 
1               5                   10                  15      


Ala Ala Leu Glu Lys Glu Ile Ala Ala Leu Glu Lys 
            20                  25              


<210>  67
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic E/K helical peptide

<400>  67

Lys Ile Ala Ala Leu Lys Glu Lys Ile Ala Ala Leu Lys Glu Lys Ile 
1               5                   10                  15      


Ala Ala Leu Lys Glu 
            20      


<210>  68
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic E/K helical peptide

<400>  68

Lys Ile Ala Ala Leu Lys Glu Lys Ile Ala Ala Leu Lys Glu Lys Ile 
1               5                   10                  15      


Ala Ala Leu Lys Glu Lys Ile Ala Ala Leu Lys Glu 
            20                  25              


<210>  69
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic E/K helical peptide

<400>  69

Glu Ile Ser Ala Leu Glu Lys Glu Ile Ser Ala Leu Glu Lys Glu Ile 
1               5                   10                  15      


Ser Ala Leu Glu Lys 
            20      


<210>  70
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic E/K helical peptide

<400>  70

Glu Ile Ser Ala Leu Glu Lys Glu Ile Ser Ala Leu Glu Lys Glu Ile 
1               5                   10                  15      


Ser Ala Leu Glu Lys Glu Ile Ser Ala Leu Glu Lys 
            20                  25              


<210>  71
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic E/K helical peptide

<400>  71

Lys Ile Ser Ala Leu Lys Glu Lys Ile Ser Ala Leu Lys Glu Lys Ile 
1               5                   10                  15      


Ser Ala Leu Lys Glu 
            20      


<210>  72
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic E/K helical peptide

<400>  72

Lys Ile Ser Ala Leu Lys Glu Lys Ile Ser Ala Leu Lys Glu Lys Ile 
1               5                   10                  15      


Ser Ala Leu Lys Glu Lys Ile Ser Ala Leu Lys Glu 
            20                  25              


<210>  73
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic E/K helical peptide

<400>  73

Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val 
1               5                   10                  15      


Ala Ala Leu Glu Lys 
            20      


<210>  74
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic E/K helical peptide

<400>  74

Lys Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu Lys Val 
1               5                   10                  15      


Ala Ala Leu Lys Glu 
            20      


<210>  75
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic E/K helical peptide

<400>  75

Glu Val Ser Ala Leu Glu Lys Glu Val Ser Ala Leu Glu Lys Glu Val 
1               5                   10                  15      


Ser Ala Leu Glu Lys 
            20      


<210>  76
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic E/K helical peptide

<400>  76

Lys Val Ser Ala Leu Lys Glu Lys Val Ser Ala Leu Lys Glu Lys Val 
1               5                   10                  15      


Ser Ala Leu Lys Glu 
            20      


