                               SEQUENCE LISTING

<110> ORBSEN THERAPEUTICS LIMITED
      NATIONAL UNIVERSITY OF IRELAND, GALWAY
 
<120> MODULATORS OF SYNDECAN-2 AND USES THEREOF

<130> 49707-702.601

<140>
<141>

<150> EP 15160181.2
<151> 2015-03-20

<160> 13    

<170> PatentIn version 3.5

<210> 1
<211> 201
<212> PRT
<213> Homo sapiens

<400> 1
Met Arg Arg Ala Trp Ile Leu Leu Thr Leu Gly Leu Val Ala Cys Val 
1               5                   10                  15      


Ser Ala Glu Ser Arg Ala Glu Leu Thr Ser Asp Lys Asp Met Tyr Leu 
            20                  25                  30          


Asp Asn Ser Ser Ile Glu Glu Ala Ser Gly Val Tyr Pro Ile Asp Asp 
        35                  40                  45              


Asp Asp Tyr Ala Ser Ala Ser Gly Ser Gly Ala Asp Glu Asp Val Glu 
    50                  55                  60                  


Ser Pro Glu Leu Thr Thr Ser Arg Pro Leu Pro Lys Ile Leu Leu Thr 
65                  70                  75                  80  


Ser Ala Ala Pro Lys Val Glu Thr Thr Thr Leu Asn Ile Gln Asn Lys 
                85                  90                  95      


Ile Pro Ala Gln Thr Lys Ser Pro Glu Glu Thr Asp Lys Glu Lys Val 
            100                 105                 110         


His Leu Ser Asp Ser Glu Arg Lys Met Asp Pro Ala Glu Glu Asp Thr 
        115                 120                 125             


Asn Val Tyr Thr Glu Lys His Ser Asp Ser Leu Phe Lys Arg Thr Glu 
    130                 135                 140                 


Val Leu Ala Ala Val Ile Ala Gly Gly Val Ile Gly Phe Leu Phe Ala 
145                 150                 155                 160 


Ile Phe Leu Ile Leu Leu Leu Val Tyr Arg Met Arg Lys Lys Asp Glu 
                165                 170                 175     


Gly Ser Tyr Asp Leu Gly Glu Arg Lys Pro Ser Ser Ala Ala Tyr Gln 
            180                 185                 190         


Lys Ala Pro Thr Lys Glu Phe Tyr Ala 
        195                 200     


<210> 2
<211> 126
<212> PRT
<213> Homo sapiens

<400> 2
Glu Ser Arg Ala Glu Leu Thr Ser Asp Lys Asp Met Tyr Leu Asp Asn 
1               5                   10                  15      


Ser Ser Ile Glu Glu Ala Ser Gly Val Tyr Pro Ile Asp Asp Asp Asp 
            20                  25                  30          


Tyr Ala Ser Ala Ser Gly Ser Gly Ala Asp Glu Asp Val Glu Ser Pro 
        35                  40                  45              


Glu Leu Thr Thr Ser Arg Pro Leu Pro Lys Ile Leu Leu Thr Ser Ala 
    50                  55                  60                  


Ala Pro Lys Val Glu Thr Thr Thr Leu Asn Ile Gln Asn Lys Ile Pro 
65                  70                  75                  80  


Ala Gln Thr Lys Ser Pro Glu Glu Thr Asp Lys Glu Lys Val His Leu 
                85                  90                  95      


Ser Asp Ser Glu Arg Lys Met Asp Pro Ala Glu Glu Asp Thr Asn Val 
            100                 105                 110         


Tyr Thr Glu Lys His Ser Asp Ser Leu Phe Lys Arg Thr Glu 
        115                 120                 125     


<210> 3
<211> 3485
<212> DNA
<213> Homo sapiens

<400> 3
agtcgcccag gggagcccgg agaagcaggc tcaggaggga gggagccaga ggaaaagaag       60

aggaggagaa ggaggaggac ccggggaggg aggcgcggcg cgggaggagg aggggcgcag      120

ccgcggagcc agtggccccg cttggacgcg ctgctctcca gatacccccg gagctccagc      180

cgcgcggatc gcgcgctccc gccgctctgc ccctaaactt ctgccgtagc tccctttcaa      240

gccagcgaat ttattcctta aaaccagaaa ctgaacctcg gcacgggaaa ggagtccgcg      300

gaggagcaaa accacagcag agcaagaaga gcttcagaga gcagccttcc cggagcacca      360

actccgtgtc gggagtgcag aaaccaacaa gtgagagggc gccgcgttcc cggggcgcag      420

ctgcgggcgg cgggagcagg cgcaggagga ggaagcgagc gcccccgagc cccgagcccg      480

agtccccgag cctgagccgc aatcgctgcg gtactctgct ccggattcgt gtgcgcgggc      540

tgcgccgagc gctgggcagg aggcttcgtt ttgccctggt tgcaagcagc ggctgggagc      600

agccggtccc tggggaatat gcggcgcgcg tggatcctgc tcaccttggg cttggtggcc      660

tgcgtgtcgg cggagtcgag agcagagctg acatctgata aagacatgta ccttgacaac      720

agctccattg aagaagcttc aggagtgtat cctattgatg acgatgacta cgcttctgcg      780

tctggctcgg gagctgatga ggatgtagag agtccagagc tgacaacatc tcgaccactt      840

ccaaagatac tgttgactag tgctgctcca aaagtggaaa ccacgacgct gaatatacag      900

aacaagatac ctgctcagac aaagtcacct gaagaaactg ataaagagaa agttcacctc      960

tctgactcag aaaggaaaat ggacccagcc gaagaggata caaatgtgta tactgagaaa     1020

cactcagaca gtctgtttaa acggacagaa gtcctagcag ctgtcattgc tggtggagtt     1080

attggctttc tctttgcaat ttttcttatc ctgctgttgg tgtatcgcat gagaaagaag     1140

gatgaaggaa gctatgacct tggagaacgc aaaccatcca gtgctgctta tcagaaggca     1200

cctactaagg agttttatgc gtaaaactcc aacttagtgt ctctatttat gagatcactg     1260

aacttttcaa aataaagctt ttgcatagaa taatgaagat ctttgttttt tgttttcatt     1320

aaagagccat tctggcactt taatgataaa atcccattgt atttaaaaca tttcatgtat     1380

ttctttagaa caacataaaa ttaaaattta acatctgcag tgttctgtga atagcagtgg     1440

caaaatatta tgttatgaaa accctcgatg ttcatggaat tggtttaaac ttttatgcgc     1500

aaatacaaaa tgattgtctt tttcctatga ctcaaagatg aaagctgttt catttgtgtc     1560

agcatgtctc agattgacct taccaagttg gtcttacttt gttaatttat ctgttgtccc     1620

cttcctctcc tctgccctcc cttcttgtgc ccttaaaacc aaaccctatg ccttttgtag     1680

ctgtcatggt gcaatttgtc tttggaaaat tcagataatg gtaatttagt gtatatgtga     1740

ttttcaaata tgtaaacttt aacttccact ttgtataaat ttttaagtgt cagactatcc     1800

attttacact tgctttattt ttcattacct gtagctttgg gcagatttgc aacagcaaat     1860

taatgtgtaa aattggatta ttactacaaa accgtttagt catatctatc taatcagatc     1920

ttcttttggg aggatttgat gtaagttact gacaagcctc agcaaaccca aagatgttaa     1980

cagtatttta agaagttgct gcagattcct ttggccactg tatttgttaa tttcttgcaa     2040

tttgaaggta cgagtagagg tttaaagaaa aatcagtttt tgttcttaaa aatgcattta     2100

agttgtaaac gtctttttaa gcctttgaag tgcctctgat tctatgtaac ttgttgcaga     2160

ctggtgttaa tgagtatatg taacagttta aaaaaaaagt tggtatttta taagcacaga     2220

caattctaat ggtaactttt gtagtcttat gaatagacat aaattgtaat ttgggaacat     2280

aaaaactact gaataaatca tgtggcctaa tattgaaaat gtcactgtta taaattttgt     2340

acatttttga tcaaatgtac atctcccctt tgctaacggc cgtctgctct caaggatgac     2400

gtgggtttga tttctaagtg tttcacagtg tctgtaaatc aagaccaaag agcctgtcga     2460

tgagactgtt tattaccaga ttcacttctg aattggccag aggaaatctg aatgtattat     2520

cctgtgtgtg tctaggtaga gatattggaa ggctgccagg ggatttcgaa gtttgcaacc     2580

tttataggat aactgatggc aatattaaga cagacgcctg cttttgcaaa taacttacaa     2640

gactgtaaat tccaaagatc tgaatggggc tttcctgatg ttggtatcta aggcttaggc     2700

ctatagattg atttaccttt ggaattgtgc tccaaatgtc tactgaagct taaccgaaga     2760

actaataaat ggactacagt agctcacgtt acagggaagg agggtaggca gggaggctct     2820

gtgtgttaaa atgagggtct cactgcttta ggattgaagt ggctggaaag agtgatgcct     2880

ggggaaggag atggagttat gagggtactg tggctggtac tttctgtact aaacatttcc     2940

tttttctatt ttaccactaa ttttgtttta aactgtgagc cgtccaagtc agaagaagac     3000

agcaaaaaaa gcaacttttc caacatacaa tttactttta ataaagtatg aatatttcat     3060

tttgagaaca ttccctggaa ttgccacata attcattaaa aacatttttt taagcaacac     3120

ttggaacagt gtttacttta aatccttaat ggccttaatt aattctcaga ttcctgcccc     3180

atcacttaca gaaccaattc actttagagt gactaaaagg aaacgatagc ctagctttct     3240

aaagccacgc tgtgtccctc aattacagag ggtaggaatg ggtatacctc taactgtgca     3300

aagcagagtg aaattcaatt catagaataa caactgctgg gaatatccgt gccaggaaaa     3360

gaaaaatttc tggcaaatat tttgtcactg ctgtaaagca aaatatttgt gaaagtgcca     3420

aaataaagtc tgtcatgcca aaagtaaatc attgtataga ctgacatcca gttttcttca     3480

actgt                                                                 3485


<210> 4
<211> 79
<212> PRT
<213> Homo sapiens

<400> 4
Met Arg Arg Ala Trp Ile Leu Leu Thr Leu Gly Leu Val Ala Cys Val 
1               5                   10                  15      


Ser Ala Glu Ser Arg Ala Glu Leu Thr Ser Asp Lys Asp Met Tyr Leu 
            20                  25                  30          


Asp Asn Ser Ser Ile Glu Glu Ala Ser Gly Val Tyr Pro Ile Asp Asp 
        35                  40                  45              


Asp Asp Tyr Ala Ser Ala Ser Gly Ser Gly Ala Asp Glu Asp Val Glu 
    50                  55                  60                  


Ser Pro Glu Leu Thr Thr Ser Arg Pro Leu Pro Lys Ile Leu Leu 
65                  70                  75                  


<210> 5
<211> 87
<212> PRT
<213> Homo sapiens

<400> 5
Met Arg Arg Ala Trp Ile Leu Leu Thr Leu Gly Leu Val Ala Cys Val 
1               5                   10                  15      


Ser Ala Glu Ser Arg Ala Glu Leu Thr Ser Asp Lys Asp Met Tyr Leu 
            20                  25                  30          


Asp Asn Ser Ser Ile Glu Glu Ala Ser Gly Val Tyr Pro Ile Asp Asp 
        35                  40                  45              


Asp Asp Tyr Ala Ser Ala Ser Gly Ser Gly Ala Asp Glu Asp Val Glu 
    50                  55                  60                  


Ser Pro Glu Leu Thr Thr Ser Arg Pro Leu Pro Lys Ile Leu Leu Thr 
65                  70                  75                  80  


Ser Ala Ala Pro Lys Val Glu 
                85          


<210> 6
<211> 100
<212> PRT
<213> Homo sapiens

<400> 6
Met Arg Arg Ala Trp Ile Leu Leu Thr Leu Gly Leu Val Ala Cys Val 
1               5                   10                  15      


Ser Ala Glu Ser Arg Ala Glu Leu Thr Ser Asp Lys Asp Met Tyr Leu 
            20                  25                  30          


Asp Asn Ser Ser Ile Glu Glu Ala Ser Gly Val Tyr Pro Ile Asp Asp 
        35                  40                  45              


Asp Asp Tyr Ala Ser Ala Ser Gly Ser Gly Ala Asp Glu Asp Val Glu 
    50                  55                  60                  


Ser Pro Glu Leu Thr Thr Ser Arg Pro Leu Pro Lys Ile Leu Leu Thr 
65                  70                  75                  80  


Ser Ala Ala Pro Lys Val Glu Thr Thr Thr Leu Asn Ile Gln Asn Lys 
                85                  90                  95      


Ile Pro Ala Gln 
            100 


<210> 7
<211> 144
<212> PRT
<213> Homo sapiens

<400> 7
Met Arg Arg Ala Trp Ile Leu Leu Thr Leu Gly Leu Val Ala Cys Val 
1               5                   10                  15      


Ser Ala Glu Ser Arg Ala Glu Leu Thr Ser Asp Lys Asp Met Tyr Leu 
            20                  25                  30          


Asp Asn Ser Ser Ile Glu Glu Ala Ser Gly Val Tyr Pro Ile Asp Asp 
        35                  40                  45              


Asp Asp Tyr Ala Ser Ala Ser Gly Ser Gly Ala Asp Glu Asp Val Glu 
    50                  55                  60                  


Ser Pro Glu Leu Thr Thr Ser Arg Pro Leu Pro Lys Ile Leu Leu Thr 
65                  70                  75                  80  


Ser Ala Ala Pro Lys Val Glu Thr Thr Thr Leu Asn Ile Gln Asn Lys 
                85                  90                  95      


Ile Pro Ala Gln Thr Lys Ser Pro Glu Glu Thr Asp Lys Glu Lys Val 
            100                 105                 110         


His Leu Ser Asp Ser Glu Arg Lys Met Asp Pro Ala Glu Glu Asp Thr 
        115                 120                 125             


Asn Val Tyr Thr Glu Lys His Ser Asp Ser Leu Phe Lys Arg Thr Glu 
    130                 135                 140                 


<210> 8
<211> 169
<212> PRT
<213> Homo sapiens

<400> 8
Met Arg Arg Ala Trp Ile Leu Leu Thr Leu Gly Leu Val Ala Cys Val 
1               5                   10                  15      


Ser Ala Glu Ser Arg Ala Glu Leu Thr Ser Asp Lys Asp Met Tyr Leu 
            20                  25                  30          


Asp Asn Ser Ser Ile Glu Glu Ala Ser Gly Val Tyr Pro Ile Asp Asp 
        35                  40                  45              


Asp Asp Tyr Ala Ser Ala Ser Gly Ser Gly Ala Asp Glu Asp Val Glu 
    50                  55                  60                  


Ser Pro Glu Leu Thr Thr Ser Arg Pro Leu Pro Lys Ile Leu Leu Thr 
65                  70                  75                  80  


Ser Ala Ala Pro Lys Val Glu Thr Thr Thr Leu Asn Ile Gln Asn Lys 
                85                  90                  95      


Ile Pro Ala Gln Thr Lys Ser Pro Glu Glu Thr Asp Lys Glu Lys Val 
            100                 105                 110         


His Leu Ser Asp Ser Glu Arg Lys Met Asp Pro Ala Glu Glu Asp Thr 
        115                 120                 125             


Asn Val Tyr Thr Glu Lys His Ser Asp Ser Leu Phe Lys Arg Thr Glu 
    130                 135                 140                 


Val Leu Ala Ala Val Ile Ala Gly Gly Val Ile Gly Phe Leu Phe Ala 
145                 150                 155                 160 


Ile Phe Leu Ile Leu Leu Leu Val Tyr 
                165                 


<210> 9
<211> 71
<212> PRT
<213> Homo sapiens

<400> 9
Thr Leu Gly Leu Val Ala Cys Val Ser Ala Glu Ser Arg Ala Glu Leu 
1               5                   10                  15      


Thr Ser Asp Lys Asp Met Tyr Leu Asp Asn Ser Ser Ile Glu Glu Ala 
            20                  25                  30          


Ser Gly Val Tyr Pro Ile Asp Asp Asp Asp Tyr Ala Ser Ala Ser Gly 
        35                  40                  45              


Ser Gly Ala Asp Glu Asp Val Glu Ser Pro Glu Leu Thr Thr Ser Arg 
    50                  55                  60                  


Pro Leu Pro Lys Ile Leu Leu 
65                  70      


<210> 10
<211> 69
<212> PRT
<213> Homo sapiens

<400> 10
Glu Ser Arg Ala Glu Leu Thr Ser Asp Lys Asp Met Tyr Leu Asp Asn 
1               5                   10                  15      


Ser Ser Ile Glu Glu Ala Ser Gly Val Tyr Pro Ile Asp Asp Asp Asp 
            20                  25                  30          


Tyr Ala Ser Ala Ser Gly Ser Gly Ala Asp Glu Asp Val Glu Ser Pro 
        35                  40                  45              


Glu Leu Thr Thr Ser Arg Pro Leu Pro Lys Ile Leu Leu Thr Ser Ala 
    50                  55                  60                  


Ala Pro Lys Val Glu 
65                  


<210> 11
<211> 82
<212> PRT
<213> Homo sapiens

<400> 11
Glu Ser Arg Ala Glu Leu Thr Ser Asp Lys Asp Met Tyr Leu Asp Asn 
1               5                   10                  15      


Ser Ser Ile Glu Glu Ala Ser Gly Val Tyr Pro Ile Asp Asp Asp Asp 
            20                  25                  30          


Tyr Ala Ser Ala Ser Gly Ser Gly Ala Asp Glu Asp Val Glu Ser Pro 
        35                  40                  45              


Glu Leu Thr Thr Ser Arg Pro Leu Pro Lys Ile Leu Leu Thr Ser Ala 
    50                  55                  60                  


Ala Pro Lys Val Glu Thr Thr Thr Leu Asn Ile Gln Asn Lys Ile Pro 
65                  70                  75                  80  


Ala Gln 
        


<210> 12
<211> 151
<212> PRT
<213> Homo sapiens

<400> 12
Glu Ser Arg Ala Glu Leu Thr Ser Asp Lys Asp Met Tyr Leu Asp Asn 
1               5                   10                  15      


Ser Ser Ile Glu Glu Ala Ser Gly Val Tyr Pro Ile Asp Asp Asp Asp 
            20                  25                  30          


Tyr Ala Ser Ala Ser Gly Ser Gly Ala Asp Glu Asp Val Glu Ser Pro 
        35                  40                  45              


Glu Leu Thr Thr Ser Arg Pro Leu Pro Lys Ile Leu Leu Thr Ser Ala 
    50                  55                  60                  


Ala Pro Lys Val Glu Thr Thr Thr Leu Asn Ile Gln Asn Lys Ile Pro 
65                  70                  75                  80  


Ala Gln Thr Lys Ser Pro Glu Glu Thr Asp Lys Glu Lys Val His Leu 
                85                  90                  95      


Ser Asp Ser Glu Arg Lys Met Asp Pro Ala Glu Glu Asp Thr Asn Val 
            100                 105                 110         


Tyr Thr Glu Lys His Ser Asp Ser Leu Phe Lys Arg Thr Glu Val Leu 
        115                 120                 125             


Ala Ala Val Ile Ala Gly Gly Val Ile Gly Phe Leu Phe Ala Ile Phe 
    130                 135                 140                 


Leu Ile Leu Leu Leu Val Tyr 
145                 150     


<210> 13
<211> 183
<212> PRT
<213> Homo sapiens

<400> 13
Glu Ser Arg Ala Glu Leu Thr Ser Asp Lys Asp Met Tyr Leu Asp Asn 
1               5                   10                  15      


Ser Ser Ile Glu Glu Ala Ser Gly Val Tyr Pro Ile Asp Asp Asp Asp 
            20                  25                  30          


Tyr Ala Ser Ala Ser Gly Ser Gly Ala Asp Glu Asp Val Glu Ser Pro 
        35                  40                  45              


Glu Leu Thr Thr Ser Arg Pro Leu Pro Lys Ile Leu Leu Thr Ser Ala 
    50                  55                  60                  


Ala Pro Lys Val Glu Thr Thr Thr Leu Asn Ile Gln Asn Lys Ile Pro 
65                  70                  75                  80  


Ala Gln Thr Lys Ser Pro Glu Glu Thr Asp Lys Glu Lys Val His Leu 
                85                  90                  95      


Ser Asp Ser Glu Arg Lys Met Asp Pro Ala Glu Glu Asp Thr Asn Val 
            100                 105                 110         


Tyr Thr Glu Lys His Ser Asp Ser Leu Phe Lys Arg Thr Glu Val Leu 
        115                 120                 125             


Ala Ala Val Ile Ala Gly Gly Val Ile Gly Phe Leu Phe Ala Ile Phe 
    130                 135                 140                 


Leu Ile Leu Leu Leu Val Tyr Arg Met Arg Lys Lys Asp Glu Gly Ser 
145                 150                 155                 160 


Tyr Asp Leu Gly Glu Arg Lys Pro Ser Ser Ala Ala Tyr Gln Lys Ala 
                165                 170                 175     


Pro Thr Lys Glu Phe Tyr Ala 
            180             


