                         SEQUENCE LISTING

<110>  UCL Business PLC
 
<120>  CHIMERIC ANTIGEN RECEPTOR

<130>  P106296PCT

<150>  GB 1504840.8
<151>  2015-03-23

<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  coiled coil domain

<400>  1

Asp Leu Gly Pro Gln Met Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala 
1               5                   10                  15      


Leu Gln Asp Val Arg Glu Leu Leu Arg Gln Gln Val Arg Glu Ile Thr 
            20                  25                  30          


Phe Leu Lys Asn Thr Val Met Glu Cys Asp Ala Cys Gly 
        35                  40                  45  


<210>  2
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide derived from TCR beta chain

<400>  2

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Gly 
            20      


<210>  3
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide derived from IgG1

<400>  3

Met Ser Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  4
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide derived from CD8a

<400>  4

Met Ala Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys 
            20  


<210>  5
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 Z endodomain

<400>  5

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  6
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 and CD3 Zeta endodomains

<400>  6

Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
1               5                   10                  15      


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            20                  25                  30          


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
        35                  40                  45              


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
    50                  55                  60                  


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
65                  70                  75                  80  


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
                85                  90                  95      


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
            100                 105                 110         


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
        115                 120                 125             


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
    130                 135                 140                 


His Met Gln Ala Leu Pro Pro Arg 
145                 150         


<210>  7
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28, OX40 and CD3 Zeta endodomains

<400>  7

Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
1               5                   10                  15      


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            20                  25                  30          


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Asp Gln Arg Leu Pro Pro Asp 
        35                  40                  45              


Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu 
    50                  55                  60                  


Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Arg Val Lys Phe 
65                  70                  75                  80  


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
                85                  90                  95      


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            100                 105                 110         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        115                 120                 125             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    130                 135                 140                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
145                 150                 155                 160 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                165                 170                 175     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            180                 185             


<210>  8
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOS endodomain

<400>  8

Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn 
1               5                   10                  15      


Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg 
            20                  25                  30          


Leu Thr Asp Val Thr Leu 
        35              


<210>  9
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD27 endodomain

<400>  9

Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro 
1               5                   10                  15      


Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr 
            20                  25                  30          


Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
        35                  40                  45              


<210>  10
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BTLA endodomain

<400>  10

Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser Asp Thr Ala Gly Arg 
1               5                   10                  15      


Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu Gln Thr Glu Ala 
            20                  25                  30          


Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu Thr Gly Ile Tyr 
        35                  40                  45              


Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu Gly Ser Glu Val 
    50                  55                  60                  


Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile Val Tyr Ala 
65                  70                  75                  80  


Ser Leu Asn His Ser Val Ile Gly Pro Asn Ser Arg Leu Ala Arg Asn 
                85                  90                  95      


Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val Arg Ser 
            100                 105                 110     


<210>  11
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD30 endodomain

<400>  11

His Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys Leu His Leu Cys 
1               5                   10                  15      


Tyr Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu Val Asp Ser Arg 
            20                  25                  30          


Pro Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala Ser Val Thr Glu 
        35                  40                  45              


Pro Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro Leu Met Glu Thr 
    50                  55                  60                  


Cys His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu Pro Leu Gln Asp 
65                  70                  75                  80  


Ala Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp Leu Pro Glu Pro 
                85                  90                  95      


Arg Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu Lys Ile Tyr Ile 
            100                 105                 110         


Met Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys Ala Glu Leu Pro 
        115                 120                 125             


Glu Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu Leu Glu Glu Glu 
    130                 135                 140                 


Leu Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln Glu Thr Glu Pro 
145                 150                 155                 160 


Pro Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val Glu Glu Glu Gly 
                165                 170                 175     


Lys Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys 
            180                 185             


<210>  12
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GITR endodomain

<400>  12

Gln Leu Gly Leu His Ile Trp Gln Leu Arg Ser Gln Cys Met Trp Pro 
1               5                   10                  15      


Arg Glu Thr Gln Leu Leu Leu Glu Val Pro Pro Ser Thr Glu Asp Ala 
            20                  25                  30          


Arg Ser Cys Gln Phe Pro Glu Glu Glu Arg Gly Glu Arg Ser Ala Glu 
        35                  40                  45              


Glu Lys Gly Arg Leu Gly Asp Leu Trp Val 
    50                  55              


<210>  13
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVEM endodomain

<400>  13

Cys Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile Val 
1               5                   10                  15      


Ser Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val Ile 
            20                  25                  30          


Glu Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu Glu 
        35                  40                  45              


Thr Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His 
    50                  55                  60  


<210>  14
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A-like sequence

<400>  14

Tyr His Ala Asp Tyr Tyr Lys Gln Arg Leu Ile His Asp Val Glu Met 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  15
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A-like sequence

<400>  15

His Tyr Ala Gly Tyr Phe Ala Asp Leu Leu Ile His Asp Ile Glu Thr 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  16
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A-like sequence

<400>  16

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  17
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A-like sequence

<400>  17

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  18
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A-like sequence

<400>  18

Ala Ala Arg Gln Met Leu Leu Leu Leu Ser Gly Asp Val Glu Thr Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  19
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A-like sequence

<400>  19

Arg Ala Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  20
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A-like sequence

<400>  20

Thr Arg Ala Glu Ile Glu Asp Glu Leu Ile Arg Ala Gly Ile Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  21
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A-like sequence

<400>  21

Thr Arg Ala Glu Ile Glu Asp Glu Leu Ile Arg Ala Asp Ile Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  22
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A-like sequence

<400>  22

Ala Lys Phe Gln Ile Asp Lys Ile Leu Ile Ser Gly Asp Val Glu Leu 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  23
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A-like sequence

<400>  23

Ser Ser Ile Ile Arg Thr Lys Met Leu Val Ser Gly Asp Val Glu Glu 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  24
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A-like sequence

<400>  24

Cys Asp Ala Gln Arg Gln Lys Leu Leu Leu Ser Gly Asp Ile Glu Gln 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  25
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A-like sequence

<400>  25

Tyr Pro Ile Asp Phe Gly Gly Phe Leu Val Lys Ala Asp Ser Glu Phe 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  26
<211>  647
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of the ORF of the anti-CD33 COMP CAR

<400>  26

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Ala Cys Pro Tyr Ser Asn Pro Ser Leu Cys Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser 
        35                  40                  45              


Thr Asn Val Ser Pro Ala Lys Pro Thr Thr Thr Ala Cys Pro Tyr Ser 
    50                  55                  60                  


Asn Pro Ser Leu Cys Ser Gly Gly Gly Gly Ser Pro Ala Pro Arg Pro 
65                  70                  75                  80  


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
                85                  90                  95      


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
            100                 105                 110         


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
        115                 120                 125             


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg 
    130                 135                 140                 


Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Arg Ala Glu 
145                 150                 155                 160 


Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
                165                 170                 175     


Pro Met Ala Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu 
            180                 185                 190         


Thr Asp Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
        195                 200                 205             


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu 
    210                 215                 220                 


Asp Ile Tyr Phe Asn Leu Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
225                 230                 235                 240 


Pro Lys Leu Leu Ile Tyr Asp Thr Asn Arg Leu Ala Asp Gly Val Pro 
                245                 250                 255     


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Tyr Thr Leu Thr Ile 
            260                 265                 270         


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr 
        275                 280                 285             


Lys Asn Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
    290                 295                 300                 


Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Ser Arg Ser Glu Val Gln Leu Val Glu Ser Gly 
                325                 330                 335     


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
            340                 345                 350         


Ser Gly Phe Thr Leu Ser Asn Tyr Gly Met His Trp Ile Arg Gln Ala 
        355                 360                 365             


Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Leu Asn Gly Gly 
    370                 375                 380                 


Ser Thr Tyr Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
385                 390                 395                 400 


Asp Asn Ala Lys Ser Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
                405                 410                 415     


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gln Asp Ala Tyr Thr Gly 
            420                 425                 430         


Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        435                 440                 445             


Met Asp Pro Ala Gly Ser Asp Leu Gly Pro Gln Met Leu Arg Glu Leu 
    450                 455                 460                 


Gln Glu Thr Asn Ala Ala Leu Gln Asp Val Arg Glu Leu Leu Arg Gln 
465                 470                 475                 480 


Gln Val Arg Glu Ile Thr Phe Leu Lys Asn Thr Val Met Glu Cys Asp 
                485                 490                 495     


Ala Cys Gly Ser Gly Lys Lys Asp Pro Lys Phe Trp Val Leu Val Val 
            500                 505                 510         


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
        515                 520                 525             


Ile Ile Phe Trp Val Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
    530                 535                 540                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
545                 550                 555                 560 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                565                 570                 575     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            580                 585                 590         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        595                 600                 605             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    610                 615                 620                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
625                 630                 635                 640 


Met Gln Ala Leu Pro Pro Arg 
                645         


<210>  27
<211>  638
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of the ORF of the anti-ROR-1 COMP CAR

<400>  27

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Ala Cys Pro Tyr Ser Asn Pro Ser Leu Cys Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser 
        35                  40                  45              


Thr Asn Val Ser Pro Ala Lys Pro Thr Thr Thr Ala Cys Pro Tyr Ser 
    50                  55                  60                  


Asn Pro Ser Leu Cys Ser Gly Gly Gly Gly Ser Pro Ala Pro Arg Pro 
65                  70                  75                  80  


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
                85                  90                  95      


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
            100                 105                 110         


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
        115                 120                 125             


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg 
    130                 135                 140                 


Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Arg Ala Glu 
145                 150                 155                 160 


Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
                165                 170                 175     


Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val 
            180                 185                 190         


Pro Gly Ser Thr Gly Gln Ser Val Lys Glu Ser Glu Gly Asp Leu Val 
        195                 200                 205             


Thr Pro Ala Gly Asn Leu Thr Leu Thr Cys Thr Ala Ser Gly Ser Asp 
    210                 215                 220                 


Ile Asn Asp Tyr Pro Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
225                 230                 235                 240 


Leu Glu Trp Ile Gly Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr Ala 
                245                 250                 255     


Ser Trp Val Lys Gly Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val 
            260                 265                 270         


Asp Leu Lys Met Thr Ser Leu Thr Thr Asp Asp Thr Ala Thr Tyr Phe 
        275                 280                 285             


Cys Ala Arg Gly Tyr Ser Thr Tyr Tyr Gly Asp Phe Asn Ile Trp Gly 
    290                 295                 300                 


Pro Gly Thr Leu Val Thr Ile Ser Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Met Thr Gln Thr Pro 
                325                 330                 335     


Ser Ser Thr Ser Gly Ala Val Gly Gly Thr Val Thr Ile Asn Cys Gln 
            340                 345                 350         


Ala Ser Gln Ser Ile Asp Ser Asn Leu Ala Trp Phe Gln Gln Lys Pro 
        355                 360                 365             


Gly Gln Pro Pro Thr Leu Leu Ile Tyr Arg Ala Ser Asn Leu Ala Ser 
    370                 375                 380                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Glu Tyr Thr 
385                 390                 395                 400 


Leu Thr Ile Ser Gly Val Gln Arg Glu Asp Ala Ala Thr Tyr Tyr Cys 
                405                 410                 415     


Leu Gly Gly Val Gly Asn Val Ser Tyr Arg Thr Ser Phe Gly Gly Gly 
            420                 425                 430         


Thr Glu Val Val Val Lys Arg Ser Asp Pro Ala Gly Ser Asp Leu Gly 
        435                 440                 445             


Pro Gln Met Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala Leu Gln Asp 
    450                 455                 460                 


Val Arg Glu Leu Leu Arg Gln Gln Val Arg Glu Ile Thr Phe Leu Lys 
465                 470                 475                 480 


Asn Thr Val Met Glu Cys Asp Ala Cys Gly Ser Gly Lys Lys Asp Pro 
                485                 490                 495     


Lys Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
            500                 505                 510         


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Arg Val 
        515                 520                 525             


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
    530                 535                 540                 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
545                 550                 555                 560 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
                565                 570                 575     


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
            580                 585                 590         


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
        595                 600                 605             


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
    610                 615                 620                 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
625                 630                 635             


<210>  28
<211>  1944
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of the ORF of the anti-CD33 COMP CAR

<400>  28
atgggcacca gcctgctgtg ctggatggcc ctgtgcctgc tgggcgccga ccacgccgat       60

gcctgcccct acagcaaccc cagcctgtgc agcggaggcg gcggcagcga gctgcccacc      120

cagggcacct tctccaacgt gtccaccaac gtgagcccag ccaagcccac caccaccgcc      180

tgtccttatt ccaatccttc cctgtgtagc ggagggggag gcagcccagc ccccagacct      240

cccaccccag cccccaccat cgccagccag cctctgagcc tgagacccga ggcctgccgc      300

ccagccgccg gcggcgccgt gcacaccaga ggcctggatt tcgcctgcga tatctacatc      360

tgggccccac tggccggcac ctgtggcgtg ctgctgctga gcctggtgat caccctgtac      420

tgcaaccacc gcaaccgcag gcgcgtgtgc aagtgcccca ggcccgtggt gagagccgag      480

ggcagaggca gcctgctgac ctgcggcgac gtggaggaga acccaggccc catggccgtg      540

cccactcagg tcctggggtt gttgctactg tggcttacag atgccagatg tgacatccag      600

atgacacagt ctccatcttc cctgtctgca tctgtcggag atcgcgtcac catcacctgt      660

cgagcaagtg aggacattta ttttaattta gtgtggtatc agcagaaacc aggaaaggcc      720

cctaagctcc tgatctatga tacaaatcgc ttggcagatg gggtcccatc acggttcagt      780

ggctctggat ctggcacaca gtatactcta accataagta gcctgcaacc cgaagatttc      840

gcaacctatt attgtcaaca ctataagaat tatccgctca cgttcggtca ggggaccaag      900

ctggaaatca aaagatctgg tggcggaggg tcaggaggcg gaggcagcgg aggcggtggc      960

tcgggaggcg gaggctcgag atctgaggtg cagttggtgg agtctggggg cggcttggtg     1020

cagcctggag ggtccctgag gctctcctgt gcagcctcag gattcactct cagtaattat     1080

ggcatgcact ggatcaggca ggctccaggg aagggtctgg agtgggtctc gtctattagt     1140

cttaatggtg gtagcactta ctatcgagac tccgtgaagg gccgattcac tatctccagg     1200

gacaatgcaa aaagcaccct ctaccttcaa atgaatagtc tgagggccga ggacacggcc     1260

gtctattact gtgcagcaca ggacgcttat acgggaggtt actttgatta ctggggccaa     1320

ggaacgctgg tcacagtctc gtctatggat cccgccggga gcgacctggg ccctcagatg     1380

ctgcgggagc tgcaggagac aaatgccgcc ctgcaggacg tgcgcgagct gctgagacag     1440

caggtgcggg agattacatt cctgaagaac accgtgatgg agtgcgatgc ctgcggatct     1500

gggaagaagg accccaagtt ctgggtcctg gtggtggtgg gaggcgtgct ggcctgttac     1560

tctctcctgg tgaccgtggc cttcatcatc ttttgggtgc gctcccgggt gaagttttct     1620

cgctctgccg atgccccagc ctatcagcag ggccagaatc agctgtacaa tgaactgaac     1680

ctgggcaggc gggaggagta cgacgtgctg gataagcgga gaggcagaga ccccgagatg     1740

ggcggcaaac cacggcgcaa aaatccccag gagggactct ataacgagct gcagaaggac     1800

aaaatggccg aggcctattc cgagatcggc atgaagggag agagaagacg cggaaagggc     1860

cacgacggcc tgtatcaggg attgtccacc gctacaaaag atacatatga tgccctgcac     1920

atgcaggccc tgccacccag atga                                            1944


<210>  29
<211>  1914
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of the ORF of the anti-ROR-1 COMP CAR

<400>  29
atgggcacca gcctgctgtg ctggatggcc ctgtgcctgc tgggcgccga ccacgccgat       60

gcctgcccct acagcaaccc cagcctgtgc agcggaggcg gcggcagcga gctgcccacc      120

cagggcacct tctccaacgt gtccaccaac gtgagcccag ccaagcccac caccaccgcc      180

tgtccttatt ccaatccttc cctgtgtagc ggagggggag gcagcccagc ccccagacct      240

cccaccccag cccccaccat cgccagccag cctctgagcc tgagacccga ggcctgccgc      300

ccagccgccg gcggcgccgt gcacaccaga ggcctggatt tcgcctgcga tatctacatc      360

tgggccccac tggccggcac ctgtggcgtg ctgctgctga gcctggtgat caccctgtac      420

tgcaaccacc gcaaccgcag gcgcgtgtgc aagtgcccca ggcccgtggt gagagccgag      480

ggcagaggca gcctgctgac ctgcggcgac gtggaggaga acccaggccc catggagacc      540

gacaccctgc tgctgtgggt gctgctgctg tgggtgcccg gcagcaccgg ccagagcgtg      600

aaggagagcg agggcgacct ggtgacccca gccggcaacc tgaccctgac ctgcaccgcc      660

agcggcagcg acatcaacga ctaccccatc agctgggtgc ggcaggcccc aggcaagggc      720

ctggagtgga tcggcttcat caacagcggc ggcagcacct ggtacgccag ctgggtgaag      780

ggccggttca ccatcagccg gaccagcacc accgtggacc tgaagatgac cagcctgacc      840

accgacgaca ccgccaccta cttctgcgcc agaggctaca gcacctacta cggcgacttc      900

aacatctggg gacccggcac cctggtgacc atcagcagcg gaggcggagg gtctgggggc      960

ggcggtagcg gcggaggagg gagcgagctg gtgatgaccc agaccccaag cagcaccagc     1020

ggcgccgtgg gcggcaccgt gaccatcaac tgccaggcca gccagagcat cgacagcaac     1080

ctggcctggt tccagcagaa gcctggccag ccacccaccc tgctgatcta ccgggccagc     1140

aacctggcca gcggcgtgcc cagccggttc agcggcagcc ggagcggcac cgagtacacc     1200

ctgaccatca gcggcgtgca gcgggaggac gccgccacct actactgcct gggcggagtg     1260

ggcaacgtga gctaccggac cagcttcggc ggaggcaccg aggtggtggt gaagcggtcg     1320

gatcccgccg ggagcgacct gggccctcag atgctgcggg agctgcagga gacaaatgcc     1380

gccctgcagg acgtgcgcga gctgctgaga cagcaggtgc gggagattac attcctgaag     1440

aacaccgtga tggagtgcga tgcctgcgga tctgggaaga aggaccccaa gttctgggtc     1500

ctggtggtgg tgggaggcgt gctggcctgt tactctctcc tggtgaccgt ggccttcatc     1560

atcttttggg tgcgctcccg ggtgaagttt tctcgctctg ccgatgcccc agcctatcag     1620

cagggccaga atcagctgta caatgaactg aacctgggca ggcgggagga gtacgacgtg     1680

ctggataagc ggagaggcag agaccccgag atgggcggca aaccacggcg caaaaatccc     1740

caggagggac tctataacga gctgcagaag gacaaaatgg ccgaggccta ttccgagatc     1800

ggcatgaagg gagagagaag acgcggaaag ggccacgacg gcctgtatca gggattgtcc     1860

accgctacaa aagatacata tgatgccctg cacatgcagg ccctgccacc caga           1914


<210>  30
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Kinesin motor protein: parallel homodimer

<400>  30

Met His Ala Ala Leu Ser Thr Glu Val Val His Leu Arg Gln Arg Thr 
1               5                   10                  15      


Glu Glu Leu Leu Arg Cys Asn Glu Gln Gln Ala Ala Glu Leu Glu Thr 
            20                  25                  30          


Cys Lys Glu Gln Leu Phe Gln Ser Asn Met Glu Arg Lys Glu Leu His 
        35                  40                  45              


Asn Thr Val Met Asp Leu Arg Gly Asn 
    50                  55          


<210>  31
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hepatitis D delta antigen: parallel homodimer

<400>  31

Gly Arg Glu Asp Ile Leu Glu Gln Trp Val Ser Gly Arg Lys Lys Leu 
1               5                   10                  15      


Glu Glu Leu Glu Arg Asp Leu Arg Lys Leu Lys Lys Lys Ile Lys Lys 
            20                  25                  30          


Leu Glu Glu Asp Asn Pro Trp Leu Gly Asn Ile Lys Gly Ile Ile Gly 
        35                  40                  45              


Lys Tyr 
    50  


<210>  32
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Archaeal box C/D sRNP core protein: anti-parallel heterodimer

<400>  32

Arg Tyr Val Val Ala Leu Val Lys Ala Leu Glu Glu Ile Asp Glu Ser 
1               5                   10                  15      


Ile Asn Met Leu Asn Glu Lys Leu Glu Asp Ile Arg Ala Val Lys Glu 
            20                  25                  30          


Ser Glu Ile Thr Glu Lys Phe Glu Lys Lys Ile Arg Glu Leu Arg Glu 
        35                  40                  45              


Leu Arg Arg Asp Val Glu Arg Glu Ile Glu Glu Val Met 
    50                  55                  60      


<210>  33
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mannose-binding protein A: parallel homotrimer

<400>  33

Ala Ile Glu Val Lys Leu Ala Asn Met Glu Ala Glu Ile Asn Thr Leu 
1               5                   10                  15      


Lys Ser Lys Leu Glu Leu Thr Asn Lys Leu His Ala Phe Ser Met 
            20                  25                  30      


<210>  34
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coiled-coil serine-rich protein 1: parallel homotrimer

<400>  34

Glu Trp Glu Ala Leu Glu Lys Lys Leu Ala Ala Leu Glu Ser Lys Leu 
1               5                   10                  15      


Gln Ala Leu Glu Lys Lys Leu Glu Ala Leu Glu His Gly 
            20                  25                  


<210>  35
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide release factor 2: anti-parallel heterotrimer Chain A

<400>  35

Ile Asn Pro Val Asn Asn Arg Ile Gln Asp Leu Thr Glu Arg Ser Asp 
1               5                   10                  15      


Val Leu Arg Gly Tyr Leu Asp Tyr 
            20                  


<210>  36
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide release factor 2: anti-parallel heterotrimer Chain B

<400>  36

Val Val Asp Thr Leu Asp Gln Met Lys Gln Gly Leu Glu Asp Val Ser 
1               5                   10                  15      


Gly Leu Leu Glu Leu Ala Val Glu Ala Asp Asp Glu Glu Thr Phe Asn 
            20                  25                  30          


Glu Ala Val Ala Glu Leu Asp Ala Leu Glu Glu Lys Leu Ala Gln Leu 
        35                  40                  45              


Glu Phe Arg 
    50      


<210>  37
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SNAP-25 and SNARE: parallel heterotetramer Chain A

<400>  37

Ile Glu Thr Arg His Ser Glu Ile Ile Lys Leu Glu Asn Ser Ile Arg 
1               5                   10                  15      


Glu Leu His Asp Met Phe Met Asp Met Ala Met Leu Val Glu Ser Gln 
            20                  25                  30          


Gly Glu Met Ile Asp Arg Ile Glu Tyr Asn Val Glu His Ala Val Asp 
        35                  40                  45              


Tyr Val Glu 
    50      


<210>  38
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SNAP-25 and SNARE: parallel heterotetramer Chain B

<400>  38

Ala Leu Ser Glu Ile Glu Thr Arg His Ser Glu Ile Ile Lys Leu Glu 
1               5                   10                  15      


Asn Ser Ile Arg Glu Leu His Asp Met Phe Met Asp Met Ala Met Leu 
            20                  25                  30          


Val Glu Ser Gln Gly Glu Met Ile Asp Arg Ile Glu Tyr Asn Val Glu 
        35                  40                  45              


His Ala Val Asp Tyr Val Glu Arg Ala Val Ser Asp Thr Lys Lys Ala 
    50                  55                  60                  


Val Lys Tyr 
65          


<210>  39
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SNAP-25 and SNARE: parallel heterotetramer Chain C

<400>  39

Glu Leu Glu Glu Met Gln Arg Arg Ala Asp Gln Leu Ala Asp Glu Ser 
1               5                   10                  15      


Leu Glu Ser Thr Arg Arg Met Leu Gln Leu Val Glu Glu Ser Lys Asp 
            20                  25                  30          


Ala Gly Ile Arg Thr Leu Val Met Leu Asp Glu Gln Gly Glu Gln Leu 
        35                  40                  45              


Glu Arg Ile Glu Glu Gly Met Asp Gln Ile Asn Lys Asp Met Lys Glu 
    50                  55                  60                  


Ala Glu Lys Asn Leu 
65                  


<210>  40
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SNAP-25 and SNARE: parallel heterotetramer Chain D

<400>  40

Ile Glu Thr Arg His Ser Glu Ile Ile Lys Leu Glu Asn Ser Ile Arg 
1               5                   10                  15      


Glu Leu His Asp Met Phe Met Asp Met Ala Met Leu Val Glu Ser Gln 
            20                  25                  30          


Gly Glu Met Ile Asp Arg Ile Glu Tyr Asn Val Glu His Ala Val Asp 
        35                  40                  45              


Tyr Val Glu 
    50      


<210>  41
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lac repressor: parallel homotetramer

<400>  41

Ser Pro Arg Ala Leu Ala Asp Ser Leu Met Gln Leu Ala Arg Gln Val 
1               5                   10                  15      


Ser Arg Leu Glu 
            20  


<210>  42
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Apolipoprotein E: anti-parallel heterotetramer

<400>  42

Ser Gly Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe Trp Asp Tyr Leu 
1               5                   10                  15      


Arg Trp Val Gln Thr Leu Ser Glu Gln Val Gln Glu Glu Leu Leu Ser 
            20                  25                  30          


Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp Glu Thr Met Lys 
        35                  40                  45              


Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln Leu Thr Ala Arg 
    50                  55                  60                  


Leu Ser Lys Glu Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met 
65                  70                  75                  80  


Glu Asp Val Cys Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala 
                85                  90                  95      


Met Leu Gly Gln Ser Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His 
            100                 105                 110         


Leu Arg Lys Leu Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu Gln 
        115                 120                 125             


Lys Arg Leu Ala Val Tyr Gln Ala 
    130                 135     


<210>  43
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heterodimerization domain

<400>  43

Gln Leu Glu Lys Glu Leu Gln Ala Leu Glu Lys Glu Asn Ala Gln Leu 
1               5                   10                  15      


Glu Trp Glu Leu Gln Ala Leu Glu Lys Glu Leu Ala Gln 
            20                  25                  


<210>  44
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heterodimerization domain

<400>  44

Gln Leu Glu Lys Lys Leu Gln Ala Leu Lys Lys Lys Asn Ala Gln Leu 
1               5                   10                  15      


Lys Trp Lys Leu Gln Ala Leu Lys Lys Lys Leu Ala Gln 
            20                  25                  


<210>  45
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dimerization and docking domain (DDD1)

<400>  45

Ser His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly Tyr 
1               5                   10                  15      


Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe Ala 
            20                  25                  30          


Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  


<210>  46
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anchoring domain (AD1)

<400>  46

Val Gln Ile Glu Tyr Leu Ala Lys Gln Ile Val Asp Asn Ala Ile Gln 
1               5                   10                  15      


Gln Ala 
        


<210>  47
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated COMP

<400>  47

Gln Gln Val Arg Glu Ile Thr Phe Leu Lys Asn Thr Val Met Glu Cys 
1               5                   10                  15      


Asp Ala Cys Gly 
            20  


<210>  48
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus Tobacco Etch Virus (TEV) cleavage site

<400>  48

Glu Asn Leu Tyr Phe Gln Ser 
1               5           


