                         SEQUENCE LISTING

<110>  The University of Nottingham
 
<120>  Antifungal Composition/Treatment

<130>  JA76778P.WOP

<150>  GB1505043.8
<151>  2015-03-25

<150>  GB1522534.5
<151>  2015-12-21

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  859
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  1

Met Ser Arg Lys Ser Ser Thr Glu Tyr Val His Asn Gln Glu Asp Ala 
1               5                   10                  15      


Asp Ile Glu Val Phe Glu Ser Glu Tyr Arg Thr Tyr Arg Glu Ser Glu 
            20                  25                  30          


Ala Ala Glu Asn Arg Asp Gly Leu His Asn Gly Asp Glu Glu Asn Trp 
        35                  40                  45              


Lys Val Asn Ser Ser Lys Gln Lys Phe Gly Val Thr Lys Asn Glu Leu 
    50                  55                  60                  


Ser Asp Val Leu Tyr Asp Ser Ile Pro Ala Tyr Glu Glu Ser Thr Val 
65                  70                  75                  80  


Thr Leu Lys Glu Tyr Tyr Asp His Ser Ile Lys Asn Asn Leu Thr Ala 
                85                  90                  95      


Lys Ser Ala Gly Ser Tyr Leu Val Ser Leu Phe Pro Ile Ile Lys Trp 
            100                 105                 110         


Phe Pro His Tyr Asn Phe Thr Trp Gly Tyr Ala Asp Leu Val Ala Gly 
        115                 120                 125             


Ile Thr Val Gly Cys Val Leu Val Pro Gln Ser Met Ser Tyr Ala Gln 
    130                 135                 140                 


Ile Ala Ser Leu Ser Pro Glu Tyr Gly Leu Tyr Ser Ser Phe Ile Gly 
145                 150                 155                 160 


Ala Phe Ile Tyr Ser Leu Phe Ala Thr Ser Lys Asp Val Cys Ile Gly 
                165                 170                 175     


Pro Val Ala Val Met Ser Leu Gln Thr Ala Lys Val Ile Ala Glu Val 
            180                 185                 190         


Leu Lys Lys Tyr Pro Glu Asp Gln Thr Glu Val Thr Ala Pro Ile Ile 
        195                 200                 205             


Ala Thr Thr Leu Cys Leu Leu Cys Gly Ile Val Ala Thr Gly Leu Gly 
    210                 215                 220                 


Ile Leu Arg Leu Gly Phe Leu Val Glu Leu Ile Ser Leu Asn Ala Val 
225                 230                 235                 240 


Ala Gly Phe Met Thr Gly Ser Ala Phe Asn Ile Ile Trp Gly Gln Ile 
                245                 250                 255     


Pro Ala Leu Met Gly Tyr Asn Ser Leu Val Asn Thr Arg Glu Ala Thr 
            260                 265                 270         


Tyr Lys Val Val Ile Asn Thr Leu Lys His Leu Pro Asn Thr Lys Leu 
        275                 280                 285             


Asp Ala Val Phe Gly Leu Ile Pro Leu Val Ile Leu Tyr Val Trp Lys 
    290                 295                 300                 


Trp Trp Cys Gly Thr Phe Gly Ile Thr Leu Ala Asp Arg Tyr Tyr Arg 
305                 310                 315                 320 


Asn Gln Pro Lys Val Ala Asn Arg Leu Lys Ser Phe Tyr Phe Tyr Ala 
                325                 330                 335     


Gln Ala Met Arg Asn Ala Val Val Ile Val Val Phe Thr Ala Ile Ser 
            340                 345                 350         


Trp Ser Ile Thr Arg Asn Lys Ser Ser Lys Asp Arg Pro Ile Ser Ile 
        355                 360                 365             


Leu Gly Thr Val Pro Ser Gly Leu Asn Glu Val Gly Val Met Lys Ile 
    370                 375                 380                 


Pro Asp Gly Leu Leu Ser Asn Met Ser Ser Glu Ile Pro Ala Ser Ile 
385                 390                 395                 400 


Ile Val Leu Val Leu Glu His Ile Ala Ile Ser Lys Ser Phe Gly Arg 
                405                 410                 415     


Ile Asn Asp Tyr Lys Val Val Pro Asp Gln Glu Leu Ile Ala Ile Gly 
            420                 425                 430         


Val Thr Asn Leu Ile Gly Thr Phe Phe His Ser Tyr Pro Ala Thr Gly 
        435                 440                 445             


Ser Phe Ser Arg Ser Ala Leu Lys Ala Lys Cys Asn Val Arg Thr Pro 
    450                 455                 460                 


Phe Ser Gly Val Phe Thr Gly Gly Cys Val Leu Leu Ala Leu Tyr Cys 
465                 470                 475                 480 


Leu Thr Asp Ala Phe Phe Phe Ile Pro Lys Ala Thr Leu Ser Ala Val 
                485                 490                 495     


Ile Ile His Ala Val Ser Asp Leu Leu Thr Ser Tyr Lys Thr Thr Trp 
            500                 505                 510         


Thr Phe Trp Lys Thr Asn Pro Leu Asp Cys Ile Ser Phe Ile Val Thr 
        515                 520                 525             


Val Phe Ile Thr Val Phe Ser Ser Ile Glu Asn Gly Ile Tyr Phe Ala 
    530                 535                 540                 


Met Cys Trp Ser Cys Ala Met Leu Leu Leu Lys Gln Ala Phe Pro Ala 
545                 550                 555                 560 


Gly Lys Phe Leu Gly Arg Val Glu Val Ala Glu Val Leu Asn Pro Thr 
                565                 570                 575     


Val Gln Glu Asp Ile Asp Ala Val Ile Ser Ser Asn Glu Leu Pro Asn 
            580                 585                 590         


Glu Leu Asn Lys Gln Val Lys Ser Thr Val Glu Val Leu Pro Ala Pro 
        595                 600                 605             


Glu Tyr Lys Phe Ser Val Lys Trp Val Pro Phe Asp His Gly Tyr Ser 
    610                 615                 620                 


Arg Glu Leu Asn Ile Asn Thr Thr Val Arg Pro Pro Pro Pro Gly Val 
625                 630                 635                 640 


Ile Val Tyr Arg Leu Gly Asp Ser Phe Thr Tyr Val Asn Cys Ser Arg 
                645                 650                 655     


His Tyr Asp Ile Ile Phe Asp Arg Ile Lys Glu Glu Thr Arg Arg Gly 
            660                 665                 670         


Gln Leu Ile Thr Leu Arg Lys Lys Ser Asp Arg Pro Trp Asn Asp Pro 
        675                 680                 685             


Gly Glu Trp Lys Met Pro Asp Ser Leu Lys Ser Leu Phe Lys Phe Lys 
    690                 695                 700                 


Arg His Ser Ala Thr Thr Asn Ser Asp Leu Pro Ile Ser Asn Gly Ser 
705                 710                 715                 720 


Ser Asn Gly Glu Thr Tyr Glu Lys Pro Leu Leu Lys Val Val Cys Leu 
                725                 730                 735     


Asp Phe Ser Gln Val Ala Gln Val Asp Ser Thr Ala Val Gln Ser Leu 
            740                 745                 750         


Val Asp Leu Arg Lys Ala Val Asn Arg Tyr Ala Asp Arg Gln Val Glu 
        755                 760                 765             


Phe His Phe Ala Gly Ile Ile Ser Pro Trp Ile Lys Arg Ser Leu Leu 
    770                 775                 780                 


Ser Val Lys Phe Gly Thr Thr Asn Glu Glu Tyr Ser Asp Asp Ser Ile 
785                 790                 795                 800 


Ile Ala Gly His Ser Ser Phe His Val Ala Lys Val Leu Lys Asp Asp 
                805                 810                 815     


Val Asp Tyr Thr Asp Glu Asp Ser Arg Ile Ser Thr Ser Tyr Ser Asn 
            820                 825                 830         


Tyr Glu Thr Leu Cys Ala Ala Thr Gly Thr Asn Leu Pro Phe Phe His 
        835                 840                 845             


Ile Asp Ile Pro Asp Phe Ser Lys Trp Asp Val 
    850                 855                 


<210>  2
<211>  893
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  2

Met Ser Arg Glu Gly Tyr Pro Asn Phe Glu Glu Val Glu Ile Pro Asp 
1               5                   10                  15      


Phe Gln Glu Thr Asn Asn Thr Val Pro Asp Leu Asp Asp Leu Glu Leu 
            20                  25                  30          


Glu Tyr Asp Gln Tyr Lys Asn Asn Glu Asn Asn Asp Thr Phe Asn Asp 
        35                  40                  45              


Lys Asp Leu Glu Ser Asn Ser Val Ala Lys His Asn Ala Val Asn Ser 
    50                  55                  60                  


Ser Lys Gly Val Lys Gly Ser Lys Ile Asp Tyr Phe Asn Pro Ser Asp 
65                  70                  75                  80  


Val Ser Leu Tyr Asp Asn Ser Val Ser Gln Phe Glu Glu Thr Thr Val 
                85                  90                  95      


Ser Leu Lys Glu Tyr Tyr Asp His Ser Ile Arg Ser His Leu Thr Val 
            100                 105                 110         


Lys Gly Ala Cys Ser Tyr Leu Lys Ser Val Phe Pro Ile Ile Asn Trp 
        115                 120                 125             


Leu Pro His Tyr Asn Phe Ser Trp Phe Thr Ala Asp Leu Ile Ala Gly 
    130                 135                 140                 


Ile Thr Ile Gly Cys Val Leu Val Pro Gln Ser Met Ser Tyr Ala Gln 
145                 150                 155                 160 


Val Ala Thr Leu Pro Ala Gln Tyr Gly Leu Tyr Ser Ser Phe Ile Gly 
                165                 170                 175     


Ala Tyr Ser Tyr Ser Phe Phe Ala Thr Ser Lys Asp Val Cys Ile Gly 
            180                 185                 190         


Pro Val Ala Val Met Ser Leu Gln Thr Ala Lys Val Ile Ala Asp Val 
        195                 200                 205             


Thr Ala Lys Tyr Pro Asp Gly Asp Ser Ala Ile Thr Gly Pro Val Ile 
    210                 215                 220                 


Ala Thr Thr Leu Ala Leu Leu Cys Gly Ile Ile Ser Ala Ala Val Gly 
225                 230                 235                 240 


Phe Leu Arg Leu Gly Phe Leu Val Glu Leu Ile Ser Leu Asn Ala Val 
                245                 250                 255     


Ala Gly Phe Met Thr Gly Ser Ala Phe Asn Ile Leu Trp Gly Gln Val 
            260                 265                 270         


Pro Ala Leu Met Gly Tyr Asn Ser Leu Val Asn Thr Arg Ala Ala Thr 
        275                 280                 285             


Tyr Lys Val Val Ile Glu Thr Leu Lys His Leu Pro Asp Thr Lys Leu 
    290                 295                 300                 


Asp Ala Val Phe Gly Leu Ile Pro Leu Phe Leu Leu Tyr Val Trp Lys 
305                 310                 315                 320 


Trp Trp Cys Gly Thr Tyr Gly Pro Arg Leu Asn Asp Arg Tyr Asn Ser 
                325                 330                 335     


Lys Asn Pro Arg Leu His Lys Ile Ile Lys Trp Thr Tyr Phe Tyr Ala 
            340                 345                 350         


Gln Ala Ser Arg Asn Gly Ile Ile Ile Ile Val Phe Thr Cys Ile Gly 
        355                 360                 365             


Trp Ala Ile Thr Arg Gly Lys Ser Lys Ser Glu Arg Pro Ile Ser Ile 
    370                 375                 380                 


Leu Gly Ser Val Pro Ser Gly Leu Lys Glu Val Gly Val Phe His Val 
385                 390                 395                 400 


Pro Pro Gly Leu Met Ser Lys Leu Gly Pro Asn Leu Pro Ala Ser Ile 
                405                 410                 415     


Ile Val Leu Leu Leu Glu His Ile Ala Ile Ser Lys Ser Phe Gly Arg 
            420                 425                 430         


Ile Asn Asp Tyr Lys Val Val Pro Asp Gln Glu Leu Ile Ala Ile Gly 
        435                 440                 445             


Val Ser Asn Leu Leu Gly Thr Phe Phe Asn Ala Tyr Pro Ala Thr Gly 
    450                 455                 460                 


Ser Phe Ser Arg Ser Ala Leu Lys Ala Lys Cys Asn Val Arg Thr Pro 
465                 470                 475                 480 


Leu Ser Gly Leu Phe Ser Gly Ser Cys Val Leu Leu Ala Leu Tyr Cys 
                485                 490                 495     


Leu Thr Gly Ala Phe Phe Tyr Ile Pro Lys Ala Thr Leu Ser Ala Val 
            500                 505                 510         


Ile Ile His Ala Val Ser Asp Leu Leu Ala Ser Tyr Gln Thr Thr Trp 
        515                 520                 525             


Asn Phe Trp Lys Met Asn Pro Leu Asp Phe Ile Cys Phe Ile Val Thr 
    530                 535                 540                 


Val Leu Ile Thr Val Phe Ala Ser Ile Glu Asp Gly Ile Tyr Phe Ala 
545                 550                 555                 560 


Met Cys Trp Ser Cys Ala Met Leu Ile Leu Lys Val Ala Phe Pro Ala 
                565                 570                 575     


Gly Lys Phe Leu Gly Arg Val Glu Val Ala Glu Val Thr Asp Ala Tyr 
            580                 585                 590         


Val Arg Pro Asp Ser Asp Val Val Ser Tyr Val Ser Glu Asn Asn Asn 
        595                 600                 605             


Gly Ile Ser Thr Leu Glu Asp Gly Gly Glu Asp Asp Lys Glu Ser Ser 
    610                 615                 620                 


Thr Lys Tyr Val Thr Asn Ser Ser Lys Lys Ile Glu Thr Asn Val Gln 
625                 630                 635                 640 


Thr Lys Gly Phe Asp Ser Pro Ser Ser Ser Ile Ser Gln Pro Arg Ile 
                645                 650                 655     


Lys Tyr His Thr Lys Trp Ile Pro Phe Asp His Lys Tyr Thr Arg Glu 
            660                 665                 670         


Leu Asn Pro Asp Val Gln Ile Leu Pro Pro Pro Asp Gly Val Leu Val 
        675                 680                 685             


Tyr Arg Leu Ser Glu Ser Tyr Thr Tyr Leu Asn Cys Ser Arg His Tyr 
    690                 695                 700                 


Asn Ile Ile Thr Glu Glu Val Lys Lys Val Thr Arg Arg Gly Gln Leu 
705                 710                 715                 720 


Ile Arg His Arg Lys Lys Ser Asp Arg Pro Trp Asn Asp Pro Gly Pro 
                725                 730                 735     


Trp Glu Ala Pro Ala Phe Leu Lys Asn Leu Lys Phe Trp Lys Lys Arg 
            740                 745                 750         


Glu Asn Asp Pro Glu Ser Met Glu Asn Ala Pro Ser Thr Ser Val Asp 
        755                 760                 765             


Val Glu Arg Asp Asp Arg Pro Leu Leu Lys Ile Leu Cys Leu Asp Phe 
    770                 775                 780                 


Ser Gln Val Ala Gln Thr Asp Ala Thr Ala Leu Gln Ser Leu Val Asp 
785                 790                 795                 800 


Leu Arg Lys Ala Ile Asn Gln Tyr Ala Asp Arg Gln Val Glu Phe His 
                805                 810                 815     


Phe Val Gly Ile Ile Ser Pro Trp Val Lys Arg Gly Leu Ile Ser Arg 
            820                 825                 830         


Gly Phe Gly Thr Leu Asn Glu Glu Tyr Ser Asp Glu Ser Ile Val Ala 
        835                 840                 845             


Gly His Thr Ser Tyr His Val Ala Arg Val Pro Gln Gly Glu Glu Asn 
    850                 855                 860                 


Pro Glu Lys Tyr Ser Val Tyr Thr Ala Ser Gly Thr Asn Leu Pro Phe 
865                 870                 875                 880 


Phe His Ile Asp Ile Pro Asp Phe Ala Lys Trp Asp Ile 
                885                 890             


