                         SEQUENCE LISTING

<110>  Fraunhofer-Gesellschaft zur Frderung der angewandten 
       Forschung e.V.
 
<120>  ANTI-CD89 CYTOTOXIC COMPLEX

<130>  FRA-PA20-PCT

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD89(scFv)


<220>
<221>  misc_feature
<222>  (227)..(227)
<223>  Xaa can be any naturally occurring amino acid

<400>  1

Met Ala Asp Tyr Lys Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu 
1               5                   10                  15      


Ser Ile Thr Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln 
            20                  25                  30          


Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln 
        35                  40                  45              


Arg Pro Gly Gln Ser Pro Thr Arg Leu Ile Tyr Leu Val Ser Lys Leu 
    50                  55                  60                  


Asp Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
65                  70                  75                  80  


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Trp Gln Gly Ala His Phe Pro Gln Thr Phe Gly Gly Gly Thr 
            100                 105                 110         


Lys Leu Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln 
    130                 135                 140                 


Thr Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys 
145                 150                 155                 160 


Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Ile Ile Phe Trp Val Lys 
                165                 170                 175     


Gln Ser His Gly Lys Ser Leu Glu Trp Thr Gly Asn Ile Asn Pro Tyr 
            180                 185                 190         


Tyr Gly Ser Thr Ser Tyr Asn Leu Lys Phe Lys Gly Lys Ala Thr Leu 
        195                 200                 205             


Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Asn Ser Leu 
    210                 215                 220                 


Thr Ser Xaa Asp Ser Ala Val Tyr Tyr Cys Val Arg Gly Val Tyr Tyr 
225                 230                 235                 240 


Tyr Gly Ser Ser Tyr Glu Ala Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
                245                 250                 255     


Val Thr Val Ser 
            260 


<210>  2
<211>  637
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD89(scFv)-ETA


<220>
<221>  misc_feature
<222>  (232)..(232)
<223>  Xaa can be any naturally occurring amino acid

<400>  2

Met Ala Gln Pro Ala Met Ala Asp Tyr Lys Asp Val Val Met Thr Gln 
1               5                   10                  15      


Thr Pro Leu Thr Leu Ser Ile Thr Ile Gly Gln Pro Ala Ser Ile Ser 
            20                  25                  30          


Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu 
        35                  40                  45              


Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser Pro Thr Arg Leu Ile Tyr 
    50                  55                  60                  


Leu Val Ser Lys Leu Asp Ser Gly Val Pro Asp Arg Phe Thr Gly Ser 
65                  70                  75                  80  


Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu 
                85                  90                  95      


Asp Leu Gly Ile Tyr Tyr Cys Trp Gln Gly Ala His Phe Pro Gln Thr 
            100                 105                 110         


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Gln Leu Gln Gln Thr Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
145                 150                 155                 160 


Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Ile 
                165                 170                 175     


Ile Phe Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Thr Gly 
            180                 185                 190         


Asn Ile Asn Pro Tyr Tyr Gly Ser Thr Ser Tyr Asn Leu Lys Phe Lys 
        195                 200                 205             


Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
    210                 215                 220                 


Gln Leu Asn Ser Leu Thr Ser Xaa Asp Ser Ala Val Tyr Tyr Cys Val 
225                 230                 235                 240 


Arg Gly Val Tyr Tyr Tyr Gly Ser Ser Tyr Glu Ala Phe Pro Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ala Glu Leu Ala Ser 
            260                 265                 270         


Gly Gly Pro Glu Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala 
        275                 280                 285             


Cys His Leu Pro Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly 
    290                 295                 300                 


Trp Glu Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala 
305                 310                 315                 320 


Leu Tyr Leu Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile 
                325                 330                 335     


Arg Asn Ala Leu Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala 
            340                 345                 350         


Ile Arg Glu Gln Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala 
        355                 360                 365             


Ala Glu Ser Glu Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala 
    370                 375                 380                 


Gly Ala Ala Asn Ala Asp Val Val Ser Leu Thr Cys Pro Val Ala Ala 
385                 390                 395                 400 


Gly Glu Cys Ala Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg 
                405                 410                 415     


Asn Tyr Pro Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser 
            420                 425                 430         


Phe Ser Thr Arg Gly Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln 
        435                 440                 445             


Ala His Arg Gln Leu Glu Glu Arg Gly Tyr Val Phe Val Gly Tyr His 
    450                 455                 460                 


Gly Thr Phe Leu Glu Ala Ala Gln Ser Ile Val Phe Gly Gly Val Arg 
465                 470                 475                 480 


Ala Arg Ser Gln Asp Leu Asp Ala Ile Trp Arg Gly Phe Tyr Ile Ala 
                485                 490                 495     


Gly Asp Pro Ala Leu Ala Tyr Ala Tyr Ala Gln Asp Gln Glu Pro Asp 
            500                 505                 510         


Ala Arg Gly Arg Ile Arg Asn Gly Ala Leu Leu Arg Val Tyr Val Pro 
        515                 520                 525             


Arg Ser Ser Leu Pro Gly Phe Tyr Arg Thr Ser Leu Thr Leu Ala Ala 
    530                 535                 540                 


Pro Glu Ala Ala Gly Glu Val Glu Arg Leu Ile Gly His Pro Leu Pro 
545                 550                 555                 560 


Leu Arg Leu Asp Ala Ile Thr Gly Pro Glu Glu Glu Gly Gly Arg Leu 
                565                 570                 575     


Glu Thr Ile Leu Gly Trp Pro Leu Ala Glu Arg Thr Val Val Ile Pro 
            580                 585                 590         


Ser Ala Ile Pro Thr Asp Pro Arg Asn Val Gly Gly Asp Leu Asp Pro 
        595                 600                 605             


Ser Ser Ile Pro Asp Lys Glu Gln Ala Ile Ser Ala Leu Pro Asp Tyr 
    610                 615                 620                 


Ala Ser Gln Pro Gly Lys Pro Pro Arg Glu Asp Leu Lys 
625                 630                 635         


<210>  3
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGbR201K (granzyme B mutant)-CD89(scFv)


<220>
<221>  misc_feature
<222>  (472)..(472)
<223>  Xaa can be any naturally occurring amino acid

<400>  3

Asp Asp Asp Asp Lys Ile Ile Gly Gly His Glu Ala Lys Pro His Ser 
1               5                   10                  15      


Arg Pro Tyr Met Ala Phe Leu Met Ile Trp Asp Gln Lys Ser Leu Lys 
            20                  25                  30          


Arg Cys Gly Gly Phe Leu Ile Arg Asp Asp Phe Val Leu Thr Ala Ala 
        35                  40                  45              


His Cys Trp Gly Ser Ser Ile Asn Val Thr Leu Gly Ala His Asn Ile 
    50                  55                  60                  


Lys Glu Gln Glu Pro Thr Gln Gln Phe Ile Pro Val Lys Arg Ala Ile 
65                  70                  75                  80  


Pro His Pro Ala Tyr Asn Pro Lys Asn Phe Ser Asn Asp Ile Met Glu 
                85                  90                  95      


Thr Leu Leu Gln Leu Glu Arg Lys Ala Lys Arg Thr Arg Ala Val Gln 
            100                 105                 110         


Pro Leu Arg Leu Pro Ser Asn Lys Ala Gln Val Lys Pro Gly Gln Thr 
        115                 120                 125             


Cys Ser Val Ala Gly Trp Gly Gln Thr Ala Pro Leu Gly Lys His Ser 
    130                 135                 140                 


His Thr Leu Gln Glu Val Lys Met Thr Val Gln Glu Asp Arg Lys Cys 
145                 150                 155                 160 


Glu Ser Asp Leu Arg His Tyr Tyr Asp Ser Thr Ile Glu Leu Cys Val 
                165                 170                 175     


Gly Asp Pro Glu Ile Lys Lys Thr Ser Phe Lys Gly Asp Ser Gly Gly 
            180                 185                 190         


Pro Leu Val Cys Asn Lys Val Ala Gln Gly Ile Val Ser Tyr Gly Lys 
        195                 200                 205             


Asn Asn Gly Met Pro Pro Arg Ala Cys Thr Lys Val Ser Ser Phe Val 
    210                 215                 220                 


His Trp Ile Lys Lys Thr Met Lys Arg Tyr Ala Glu His Glu Gly Asp 
225                 230                 235                 240 


Ala Ala Gln Pro Ala Met Ala Asp Tyr Lys Asp Val Val Met Thr Gln 
                245                 250                 255     


Thr Pro Leu Thr Leu Ser Ile Thr Ile Gly Gln Pro Ala Ser Ile Ser 
            260                 265                 270         


Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu 
        275                 280                 285             


Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser Pro Thr Arg Leu Ile Tyr 
    290                 295                 300                 


Leu Val Ser Lys Leu Asp Ser Gly Val Pro Asp Arg Phe Thr Gly Ser 
305                 310                 315                 320 


Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu 
                325                 330                 335     


Asp Leu Gly Ile Tyr Tyr Cys Trp Gln Gly Ala His Phe Pro Gln Thr 
            340                 345                 350         


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly Gly Gly Ser 
        355                 360                 365             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    370                 375                 380                 


Val Gln Leu Gln Gln Thr Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
385                 390                 395                 400 


Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Ile 
                405                 410                 415     


Ile Phe Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Thr Gly 
            420                 425                 430         


Asn Ile Asn Pro Tyr Tyr Gly Ser Thr Ser Tyr Asn Leu Lys Phe Lys 
        435                 440                 445             


Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
    450                 455                 460                 


Gln Leu Asn Ser Leu Thr Ser Xaa Asp Ser Ala Val Tyr Tyr Cys Val 
465                 470                 475                 480 


Arg Gly Val Tyr Tyr Tyr Gly Ser Ser Tyr Glu Ala Phe Pro Tyr Trp 
                485                 490                 495     


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
            500                 505     


<210>  4
<211>  382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD89(scFv)-Ang GGRR (angiogenin mutant)


<220>
<221>  misc_feature
<222>  (219)..(219)
<223>  Xaa can be any naturally occurring amino acid

<400>  4

Met Thr Gln Thr Pro Leu Thr Leu Ser Ile Thr Ile Gly Gln Pro Ala 
1               5                   10                  15      


Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys 
            20                  25                  30          


Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser Pro Thr Arg 
        35                  40                  45              


Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val 
65                  70                  75                  80  


Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Trp Gln Gly Ala His Phe 
                85                  90                  95      


Pro Gln Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Gln Gln Thr Gly Pro Glu Leu Val Lys Pro 
    130                 135                 140                 


Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr 
145                 150                 155                 160 


Asp Tyr Ile Ile Phe Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu 
                165                 170                 175     


Trp Thr Gly Asn Ile Asn Pro Tyr Tyr Gly Ser Thr Ser Tyr Asn Leu 
            180                 185                 190         


Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr 
        195                 200                 205             


Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Xaa Asp Ser Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Val Arg Gly Val Tyr Tyr Tyr Gly Ser Ser Tyr Glu Ala Phe 
225                 230                 235                 240 


Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ala Leu 
                245                 250                 255     


Glu Ser Arg Gln Asp Asn Ser Arg Tyr Thr His Phe Leu Thr Gln His 
            260                 265                 270         


Tyr Asp Ala Lys Pro Gln Gly Arg Asp Asp Arg Tyr Cys Glu Ser Ile 
        275                 280                 285             


Met Arg Arg Arg Gly Leu Thr Ser Pro Cys Lys Asp Ile Asn Thr Phe 
    290                 295                 300                 


Ile His Gly Asn Lys Arg Ser Ile Lys Ala Ile Cys Glu Asn Lys Asn 
305                 310                 315                 320 


Gly Asn Pro His Arg Glu Asn Leu Arg Ile Ser Lys Ser Ser Phe Gln 
                325                 330                 335     


Val Thr Thr Cys Lys Leu His Arg Arg Ser Pro Trp Pro Pro Cys Gln 
            340                 345                 350         


Tyr Arg Ala Thr Ala Gly Phe Arg Asn Val Val Val Ala Cys Glu Asn 
        355                 360                 365             


Gly Leu Pro Val His Leu Asp Gln Ser Ile Phe Arg Arg Pro 
    370                 375                 380         


<210>  5
<211>  647
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD89(scFv)-MAPtau


<220>
<221>  misc_feature
<222>  (222)..(222)
<223>  Xaa can be any naturally occurring amino acid

<400>  5

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Ile Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Thr Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Ala His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Thr Gly Pro Glu Leu 
    130                 135                 140                 


Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
145                 150                 155                 160 


Ser Phe Thr Asp Tyr Ile Ile Phe Trp Val Lys Gln Ser His Gly Lys 
                165                 170                 175     


Ser Leu Glu Trp Thr Gly Asn Ile Asn Pro Tyr Tyr Gly Ser Thr Ser 
            180                 185                 190         


Tyr Asn Leu Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser 
        195                 200                 205             


Ser Ser Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Xaa Asp Ser 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Val Arg Gly Val Tyr Tyr Tyr Gly Ser Ser Tyr 
225                 230                 235                 240 


Glu Ala Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
                245                 250                 255     


Ala Ala Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His 
            260                 265                 270         


Ala Gly Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr 
        275                 280                 285             


Met His Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Ala Glu 
    290                 295                 300                 


Ala Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His 
305                 310                 315                 320 


Val Thr Gln Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser 
                325                 330                 335     


Asp Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr 
            340                 345                 350         


Pro Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr 
        355                 360                 365             


Arg Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser 
    370                 375                 380                 


Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly 
385                 390                 395                 400 


Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ala Leu Pro Thr 
                405                 410                 415     


Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro 
            420                 425                 430         


Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro 
        435                 440                 445             


Met Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ala Thr Glu Asn 
    450                 455                 460                 


Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys 
465                 470                 475                 480 


Leu Asp Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile 
                485                 490                 495     


Lys His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val 
            500                 505                 510         


Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His 
        515                 520                 525             


His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp 
    530                 535                 540                 


Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr 
545                 550                 555                 560 


His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr 
                565                 570                 575     


Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val 
            580                 585                 590         


Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser 
        595                 600                 605             


Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu 
    610                 615                 620                 


Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
625                 630                 635                 640 


Pro Lys Lys Lys Arg Lys Val 
                645         


<210>  6
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  6

Gln Glu Gly Asp Phe Pro Met Pro Phe Ile Ser Ala Lys Ser Ser Pro 
1               5                   10                  15      


Val Ile Pro Leu Asp Gly Ser Val Lys Ile Gln Cys Gln Ala Ile Arg 
            20                  25                  30          


Glu Ala Tyr Leu Thr Gln Leu Met Ile Ile Lys Asn Ser Thr Tyr Arg 
        35                  40                  45              


Glu Ile Gly Arg Arg Leu Lys Phe Trp Asn Glu Thr Asp Pro Glu Phe 
    50                  55                  60                  


Val Ile Asp His Met Asp Ala Asn Lys Ala Gly Arg Tyr Gln Cys Gln 
65                  70                  75                  80  


Tyr Arg Ile Gly His Tyr Arg Phe Arg Tyr Ser Asp Thr Leu Glu Leu 
                85                  90                  95      


Val Val Thr Gly Leu Tyr Gly Lys Pro Phe Leu Ser Ala Asp Arg Gly 
            100                 105                 110         


Leu Val Leu Met Pro Gly Glu Asn Ile Ser Leu Thr Cys Ser Ser Ala 
        115                 120                 125             


His Ile Pro Phe Asp Arg Phe Ser Leu Ala Lys Glu Gly Glu Leu Ser 
    130                 135                 140                 


Leu Pro Gln His Gln Ser Gly Glu His Pro Ala Asn Phe Ser Leu Gly 
145                 150                 155                 160 


Pro Val Asp Leu Asn Val Ser Gly Ile Tyr Arg Cys Tyr Gly Trp Tyr 
                165                 170                 175     


Asn Arg Ser Pro Tyr Leu Trp Ser Phe Pro Ser Asn Ala Leu Glu Leu 
            180                 185                 190         


Val Val Thr Asp Ser Ile His Gln Asp Tyr Thr Thr Gln Asn 
        195                 200                 205     


